Abstract: A nasal delivery device for and a method of delivering a substance to a nasal cavity of a subject, the delivery device comprising: a delivery unit for delivering a flow entraining a substance to one nostril of a subject, the delivery unit including a nosepiece for fitting to a nostril of the subject; and a flow resistor unit for fitting to the other nostril of the subject, the flow resistor unit including a progressive resistor for progressively providing an increasing flow resistance to the delivered flow.

Abstract: A method is described comprising: providing a first heated volume flow of pressurized gas, a second volume flow of pre-heated dilution gas, and a third volume flow of fluid. A concentrated first aerosol is generated by exhausting at least a part of the first volume flow of pressurized gas and the third volume flow of fluid through a nozzle. A fourth volume flow of gas of opposite direction to the concentrated first aerosol is generated such that the concentrated first aerosol is arrested. Evaporation of the aerosol solvent is augmented with infrared radiation. The arrested first aerosol is then mixed with the second volume flow of dilution gas for generating a second aerosol that has been diluted. This aerosol is then concentrated with a virtual impactor.

Abstract: An inhaler (1) for delivery of a powder-form inhalation formulation from a blister strip (2) with a plurality of blister pockets (3) is proposed. A tape is used for numbering.

Abstract: The present invention includes a method for delivering medications deeper into the lungs and to the medications' pulmonary targets, which include bronchioles and alveoli. A first particularly preferred embodiment of the invention describes the use of two steps for delivery of a medication. In a first step, an aerosolized therapeutic composition or medication is administered into a patient's respiratory tract, wherein the patient may be any animal or human subject. Following the first step, an aerosolized surfactant is administered into the patient's respiratory tract that facilitates delivery of the aerosolized medication of the first step to the medication's pulmonary target. Another embodiment of the present invention contemplates an apparatus for the delivery of an aerosolized surfactant used that facilitates delivery of previously inhaled aerosolized medication.

Abstract: A method of manufacturing more than one inflatable cuff per blow molding operation is provided. The method includes using two or more molds arranged in series and/or in parallel to simultaneously form two or more cuffs. The two or more cuffs may then be used in the manufacture of two or more respective endotracheal tubes. Apparatuses and systems for simultaneously forming the two or more cuffs are also provided.

Abstract: A nasal dilator is formed as a unitary truss of laminated, vertically-stacked layers. A resilient layer provides stabilization and expansion of nasal wall outer tissues, while an adhesive layer attaches the dilator to the user's skin. Dilator component shapes are designed to facilitate manufacture with reduced material waste. Some embodiments can be assembled by the user to customize the size or configuration to personal preference.

Abstract: Methods, pharmaceutical compositions, and systems are provided which include a method for treating a pulmonary viral infectious disease in a subject. The method includes administering a pharmaceutical composition including at least one agent to a pulmonary tissue of the subject, wherein the pharmaceutical composition is administered as two or more distinct and non-overlapping particle size ranges configured to contact two or more levels of pulmonary tissue of the subject, wherein the at least one agent is configured to achieve a selected pH range in the two or more levels of pulmonary tissue of the subject.

Abstract: A single lumen endobronchial tube for selective mechanical ventilation of the lungs can include a medical tube having a single lumen with an opening at each of opposed distal and proximal ends of the tube, the opening at the proximal end of the tube being adapted for connection to an external mechanical ventilation device, and the opening at the distal end of the tube being adapted for delivery of a medical gas; a wall extending throughout the tube's entire length having an internal wall surface, an external wall surface and a thickness therebetween, a portion of the wall having an aperture and a shaft adapted to house a mechanism for sealing the aperture; a distal bronchial cuff positioned along the external wall surface and adapted to expand radially outward; and at least a first proximal tracheal cuff positioned along the external wall surface and adapted to expand radially outward.

Abstract: A Breath Actuated Inhaler having a canister with a medication dispensed when compressing the canister. Compression of the canister is prevented by a mechanism only allowing compression when an air flow is sufficient to ensure dispensing of the medication in the lungs/throat of the person. No latch or blocking mechanism is provided so that any force exerted by the person is, at all times, directed to the canister or preventing mechanism so that when no force is exerted by the user, no force is exerted in the inhaler. Prolonged exertion of such force could otherwise cause dimension changes and subsequent uncertainty of the dose size.

Abstract: An apparatus and method for treating sleep apnea and/or snoring is provided. The apparatus includes an appliance sized and structured to be placed in the pharyngeal region of a human or animal and being effective in treating sleep apnea and/or snoring, for example in maintaining openness of an oropharyngeal region of a human or animal during natural sleep, advantageously while not interfering with normal functioning of the epiglottis. The appliance may be made of a super elastic material, for example, Nitinol, and may be submucosally implanted in the pharyngeal walls.

Abstract: The ventilation module (8) regulates the inspiratory pressure (P) according to an inspiratory pressure order (AI). A control module (9) compares the breathed volume at each cycle (VTI) with a minimum volume order (VRImini) and varies the pressure order (AI) in the direction tending to maintain the breathed volume (VTI) just over the minimum (VTImini), but keeping the pressure order (AI) within the interval comprised between the two extreme values (AImini, AImaxi). Utilization to combine the advantages of the pressure mode ventilation with those of the volumetric ventilation.

Abstract: A headgear for use with a patient interface for delivering a flow of breathable gas to a patient includes at least a strap (741) adapted to position the patient interface in sealing engagement with the patient's airways. The strap is constructed from an elastomer and a first side of the strap includes a first region (215) on a portion of its surface that is textured to reduce friction with objects contacting the strap. A textured surface coating for a portion of an elastomer strap included in a headgear system is adapted to contact the skin of a patient, when in use, and the coating has a Ra value greater than zero. A vent (500) for use with a patient interface for delivering a flow of breathable gas to a patient includes a plurality of rises (580) and runs (570) in a stepped arrangement; and a plurality of holes (510) in the stepped arrangement for the venting of gas.

Abstract: A seal and a mask using a seal that includes a first end portion adapted to be coupled to a seal support, a second end portion adapted for sealing engagement with a face of a user, and a sidewall extending between the first end portion and the second end portion. The first end portion, second end portion, sidewall, or any combination thereof is formed from an elastomeric material having an elongation of at least 1000%. The seal preferably formed from a unitary piece of elastomeric material.

Abstract: An improved tracheostomy tube providing a decreased tendency to produce rubbing, pressure necrosis, ulceration and scarring of the tracheal mucosa. The tube typically includes a rigid proximal section, a flexible intermediate section, a rigid distal section, and a beveled distal tip. The flexible intermediate section has a smooth surface and bends easily in response to pressure asserted by the tracheal walls, allowing the distal rigid section of the tube to remain in a parallel orientation relative to the tracheal lumen. The distal tip of the tube is beveled to provide a greater cross-sectional area at the tube's distal section. This beveled distal tip prevents the distal section of the tube from becoming obstructed by the back wall of the trachea or causing erosion of the tracheal mucosa. The distal tip also has a beaded or rounded edge, which further minimizes the risk of damage to the tracheal mucosa and provides a guide to the clinical care specialist during suctioning.

Abstract: A dosing device can be activated by a vacuum air stream of a user for the inhalation of a powder substance, particularly medicine, which is arranged in a supply chamber and which can be brought out of the same into an open emptying-ready position by a dosing chamber of a dosing rod when the mouthpiece-closure cap is removed. In particular, in order to improve dispensing, the provision of two air paths, of which one serves to open and empty the dosing chamber, and/or the second air path penetrates directly into a ring chamber in order to mix with the air flow containing the substance.

Abstract: A nasal ventilation interface including a pair of tubes configured to deliver a ventilation gas. The tubes are attachable at a first end to a ventilation gas supply hose and engageable at a second end with a person's nostril. A coupler is configured to align the pair of tubes with the person's nostrils, wherein each tube has an absence of pneumatic interconnection with the other tube.

Abstract: Respiratory support and/or controlled mechanical ventilation of a patient are provided. A ventilation apparatus may include a ventilator, a transtracheal prosthesis, and a respiratory relief device. The transtracheal prostheses and ventilation catheter may be arranged such that the patient can breathe freely through the upper airway and/or the tracheal prostheses. Respiratory sensors may measure a breathing rate, lung pressure, airway pressure, or a combination thereof. Pulses of gas may be provided to the patient through the ventilation catheter during inspiration. The pulses may have a first volume while the patient breathes normal and a second volume when the sensors detect a cessation of breathing or reduction in breathing volume. The second volume may be provided at 1-5 times the normal breathing rate, with a volume 25-500% times the first volume, or both.

Abstract: A pressure generating system and method for generating a flow of fluid at a pressure above atmospheric pressure. The system includes a pressure generator and a valve that controls the pressure/flow of gas delivered to the patient. The system monitors energy provided to the valve, a characteristics associated with movement of the valve, a position of the valve, or any combination thereof. In addition, the controller controls an operating speed of the pressure generator such that the valve operates over a majority of the range of positions during use of the pressure support system.

Abstract: The present invention comprises a user interface for systems and methods for sedation and analgesia delivery. The user interface receives input from a user of a sedation and analgesia delivery system and relays information regarding the system, the administration of sedation and analgesia, physiological conditions to the user in a context sensitive manner. The information relayed may be displayed to the user on a touch sensitive screen or multi-layer display device. The display may be segregated geographically or may be color coded on the display device where the geographic location and/or color of the displayed information relates further information to the user.

Abstract: A method of operating a magnetic resonance imaging scanner for imaging the heart of a patient comprising inducing apnoea in the patient; sensing an electrical heart waveform; in response thereto moving the chest wall of the patient to a desired location; and triggering the scanner to image.

Abstract: Nebulizer assemblies and systems are disclosed. A nebulizer assembly includes a reservoir and a nebulizer for producing an aerosolized gas. An aerosolized gas outlet passes the aerosolized gas. A breathing gas mixing chamber is coupled to an outlet port of the nebulizer to entrain nebulized medication into a breathing gas. A system and method of heating medication in a reservoir and adding medication to a gas flow is also provided.

Abstract: An article to improve nasal passage air flow may be a strip that comprises a flexible resilient material, and has a first end and a second end, and a top surface and a bottom surface, with at least a portion of the bottom surface at the first end of the strip comprising a first adhesive surface, and at least a portion of the bottom surface at the second end of said strip comprising a second adhesive surface. The strip may serve to dilate a user's nasal passage when the first end of the strip is secured using the first adhesive bottom surface to be proximate to an alar facial groove of the user's nose, with the second end of the strip being pulled up at a slight angle and laterally to achieve desired nasal passage expansion and thereafter being secured to the user's face, at roughly a 20-25 degree angle.

Abstract: The invention provides a fail-safe module (FSM) integral with a sedation and analgesia system that meets the high-reliability needs of sedation and/or analgesia delivered by non-anesthetist practitioners. The FSM may operate in “real-time” in order to ensure optimal patient safety. The FSM may deactivate specific patient interfaces, user interfaces, and/or sedation and analgesia delivery in order to ensure patient safety and has redundant safety systems in order to provide the fail-safe module with an accurate assessment of controller functionality.

Abstract: A delivery system includes a holding chamber with first, second and third openings, and independently moveable first, second and third flow control members. A delivery system includes a holding chamber and a flow control member including a flap pivotable from an at rest position in a direction toward an outlet of a user interface and away from an output end of the holding chamber in response to a pressure being applied thereto.

Abstract: A respiratory nasal filter including an outer ring having concentric outer periphery and inner periphery sized to the periphery of a user's nasal orifice, a filter layer having an outer periphery larger than the inner periphery of the outer ring, but smaller than the outer periphery of the outer ring and an adhesive applied to said outer ring for bonding the filter layer concentrically to the outer ring and for bonding the outer ring to the columella, a nasal sill, an alar sidewall and the facet of the user's nose.

Abstract: An ambient or room air vacuum attachment or nozzle is provided proximal to the connection between a breathing circuit and the protruding inlet port of a respiratory face mask, and a tubular passageway is sealingly connected between the vacuum attachment or nozzle and a source of vacuum. By virtue of such structure, any gas escaping from the periphery of the respiratory face mask through accident or otherwise is immediately and automatically “vacuumed-up” by the proximally located vacuum attachment or nozzle and evacuated from the surrounding room environment through the vacuum source to which the ambient air vacuum nozzle and tubular passageway are connected.

Abstract: An assembly for modifying airflow into a nasopharyngeal airway or trachea of a patient. A valve assembly having an inlet and an outlet attaches to a traditional airflow generator. A valve seal within the assembly is operable by a solenoid and is adapted to cycle in response to a programmable controller circuit wherein upon activation of both the airflow generator and the controller circuit, pressurized air from the airflow generator continuously enters the inlet but passes out of the outlet of the assembly only when the solenoid causes the valve seal to retract and to at least partially unblock the outlet such that the pressurized air is converted into a single, repeatable burst exiting the outlet thereby modifying the traditional airflow.

Abstract: A method and apparatus for determining suitable settings for a servo-ventilator to be used during sleep. Respiratory characteristics of a patient are measured during an awake learning period. With these measured characteristics, a target ventilation setting may be calculated by alternative methods. The calculated setting may then be used for enforcing a minimum ventilation during a treatment period where ventilatory support is provided with a servo-controlled ventilator.

Abstract: A respiratory access assembly includes a distal plate having one port and cuff and an axially aligned proximal plate including a first port and first cuff and a second port and second cuff. The distal plate is configured to move relative to the proximal plate. The respiratory access assembly includes an actuator, which has a plurality of predetermined positions. The actuator includes a blocking portion that controls the movement of the plates. The blocking portion moves slidably within an O-ring that prevents loss of pressure from the artificial airway system. The O-ring may be molded in place using an injection molding process, thus ensuring good adhesion to the disk.

Abstract: A kink-resistant gas delivery tube configured to be directly connected to a circular male plug, the tube having an internal geometry of multiple concave and convex areas each having an apex, wherein an angle a between a tangent line to the apex of a concave area and a tangent line to a point of maximum slope between the apexes is 30 degrees or less, or wherein an angle ? between a tangent line to the apex of a convex area and a tangent line to a point of maximum slope between the apexes is 30 degrees or less.

Abstract: An oscillating positive respiratory pressure apparatus and a method of performing oscillating positive respiratory pressure therapy. The apparatus includes a housing having an interior chamber, a chamber inlet, a chamber outlet, an exhalation flow path defined between the inlet and the outlet, and a restrictor member rotatably mounted within the interior chamber. The restrictor member has an axis of rotation that is substantially perpendicular to the flow path at the inlet, and includes at least one blocking segment. Rotation of the restrictor member moves the at least one blocking segment between an open position and a closed position. Respiratory pressure at the chamber inlet oscillates between a minimum when the at least one blocking segment is in the open position and a maximum when the at least one blocking segment is in the closed position. By exhaling into the apparatus, oscillating positive expiratory pressure therapy is administered.

Abstract: The disclosure describes a novel approach for displaying information on a ventilator system. The disclosure describes a novel respiratory system including a primary display and system status display. Further, the disclosure describes a novel method for displaying ventilator information.

Abstract: An inhaler for inhaling powdered medicaments from capsules, having: a lower part which is cup-shaped, a plate latched to the lower part to close off the lower part, a capsule holder arranged on the underside of the plate, a mouthpiece that can be latched to the top of plate, and an actuating member for interacting with at least one pin for piercing a capsule in the capsule holder, where the actuating member includes a larger outer actuating member and a smaller inner actuating member, the outer actuating member forms a user-operated push-button, the inner actuating member contacts and holds the pin below a suspension element of the outer actuating member from the plate, and the point of application of force by the user onto push-button is lower than the inner actuating member.

Abstract: According to a preferred embodiment of the present invention there is provided a bite block assembly adapted for capnography and oxygen delivery to a subject, the bite block assembly including a first capnography passageway adapted for passage therethrough of exhaled breath from the subject to a capnograph and a second oxygen delivery passageway, separate from the first passageway, adapted for passage therethrough of oxygen from an oxygen source to the mouth of the subject.

Abstract: A device for use in an aerosol inhalation system for delivering aerosolized medication includes a housing that is operatively connected to a source of aerosolized medication such that the aerosolized medication is delivered to the housing. The device also includes a patient interface member removably connected to the housing and being separate therefrom. The patient interface member is in the form of a face mask for placement about a face of the patient and in communication with a mouth of the patient for delivering the aerosolized medication. The patient interface member incorporates an integral inhalation valve and safety feature for protecting against displacement of the inhaltation valve.

Abstract: Systems, devices, and methods are disclosed for the cleaning of an endotracheal tube while a patient is being supported by a ventilator connected to the endotracheal tube for the purpose of increasing the available space for airflow or to prevent the build up of materials that may constrict airflow or be a potential nidus for infection. In one embodiment, a mechanically-actuated endotracheal tube cleaning device is configured to removably receive a visualization member to provide cleaning of the endotracheal tube under direct visualization.

Abstract: A respiratory therapy device including a housing and an interrupter valve assembly. The housing is sized for handling by a patient and defines a patient breathing passage extending from a patient end and through which a patient inhales and exhales air. The interrupter valve assembly is carried by the housing and includes a control port, a valve body, and a drive mechanism. Expiratory airflow is released from the patient breathing passage through the control port. The valve body is sized to at least partially obstruct fluid flow through the control port. The drive mechanism moves the valve body relative to the control port in response to the expiratory airflow such that the valve body repeatedly transitions between a position of maximum obstruction and a position of minimum obstruction relative to the control port to create an oscillatory positive expiratory pressure effect.

Abstract: A device for dispensing a plurality of unitary doses of dry powder includes: first and second supports, an indexing mechanism adapted to move the first and second supports, the indexing mechanism and the supports being configured so that in a first dispensing state of the device, the first and second supports are respectively in engagement with and disengaged from the indexing mechanism, in a second dispensing state of the device, the second and first supports are respectively in engagement with and disengaged from the indexing mechanism, and a changeover mechanism for causing the device to pass from the first dispensing state to the second dispensing state, to lock the second support while the device is in the first dispensing state, and to lock the first support while the device is in the second dispensing state.

Abstract: Systems, methods, and/or apparatuses for acclimatizing a user to positive airway pressure (PAP) therapy are provided. Generally, a sub-therapeutic treatment pressure is provided initially. It may be ramped up to a full treatment pressure over the course of one or more therapy sessions. The pressure level may be ramped up based on, for example, sleep state, sleep phase, patient compliance with types of treatment (e.g. bilevel vs. CPAP, etc.), clinician input (either at the site, remotely, via pre-programmed smartcards, etc.), etc. Such techniques may be used alone or in combination.

Abstract: A monitoring device for monitoring a therapy device, for example, an anesthesia device or a respirator, is provided by which an alarm device for triggering an alarm when the value drops beyond a warning limit (4) is automatically activated when a determined therapy parameter drops beyond this warning limit (4). The warning limit (4) is set automatically in this case. In addition, a therapy device monitored by the monitoring device and especially an anesthesia device as well as a respirator are provided. A process for triggering an alarm as well as a process for treating a patient is also provided.

Abstract: The present disclosure provides a device and method for facilitating air flow in the nasal passage of a domestic animal. The nasal support device (NSD) disclosed herein is useful for facilitating air flow during rest, physical exertion, respiratory ailment, etc. The NSD secures to the nose of a domestic animal to support the unsupported lateral vestibular walls of the nasal passages by lifting or stenting.

Abstract: A continuous positive airway pressure system features a housing forming an airway chamber, and an air pressure inlet and an air pressure outlet. The housing further defines internally a pair of tapered air jets, and a pair of tapered air receivers. The air receivers are located downstream of the air supply jets and disposed coaxially with respective ones of the air supply jets. Each receiver has a taper in an opposite direction to the direction of the taper of the air supply jets. A pair of nasal prongs is located downstream of the air receiving jets.

Abstract: This disclosure describes systems and methods for purging narrow diameter sensor tubing, occasionally referred to as “sensor lines,” in a ventilation system. The disclosure describes a novel approach in which a series of short, periodic releases of pressurized gas through the sensor tubes are used to clear any blockages due to condensation or patient secretions.

Abstract: The invention relates to a device for the automated determination of the PEEP of a patient. Said device comprises sensors and a suitable electronic system for determining a pressure-volume characteristic curve during a P/V maneuver. The electronic system is designed in such a way as to generate, specifically in terms of breathing pressure, the difference between “lung volume during exhalation (Vdef)” and “lung volume during inhalation (Vinf)”, and to determine the maximum value of said difference. The breathing pressure is then determined, for which the volume difference has a value defined in relation to the maximum value of the volume difference. The device calculates a PEEP value on the basis of said determined breathing pressure value.

Abstract: An aerosol apparatus including a nebulizer device and a mask suitable for receiving a substance substantially in the sol state from the nebulizer device is described. The apparatus also includes a display device able to display a sequence of images to a patient while he/she is using the apparatus. The display device may be a DVD player which conveniently is able to be separated from the aerosol apparatus. The apparatus is particularly suitable for use by patients who are children.

Abstract: A portable ventilator uses a ROOTS-type blower as a compressor to reduce both the size and power consumption of the ventilator. Various functional aspects of the ventilator are delegated to multiple subassemblies having dedicated controllers and software that interact with a ventilator processor to provide user interface functions, exhalation control and flow control servos, and monitoring of patient status. The ventilator overcomes noise problems through the use of noise reducing pressure compensating orifices on the ROOTS-type blower housing and multiple baffling chambers. The ventilator is configured with a highly portable form factor, and may be used as a stand-alone device or as a docked device having a docking cradle with enhanced interface and monitoring capabilities.

Abstract: A high flow therapy system including a microprocessor, a heating element a non-sealing respiratory interface and a sensor is disclosed. The heating element is disposed in electrical communication with the microprocessor and is capable of heating a liquid to create a gas. The non-sealing respiratory interface is configured to deliver the gas to a patient. The sensor is disposed in electrical communication with the microprocessor and is configured to measure pressure in an upper airway of the patient.

Abstract: An inflatable balloon cuff may be adapted to seal a patient's trachea when associated with an endotracheal tube. These cuffs may include features that facilitate detection or visualization of the cuff, for example with ultrasound devices, to ensure proper placement of the cuff and the tube. Such surface features may include particular types of materials or shaped or protruding features that may be detected in the environment of the trachea.

Abstract: A method and a microprocessor controlled device for use in medical evaluation of the pulmonary system. The method and device incorporate two different non invasive evaluative techniques. Passive auscultation provides indicators of lung condition. Active auscultation, a different evaluative technique, provides information or indications generally not available or provided from passive auscultation. Combining the information from both techniques greatly improves the ability to provide effective medical treatment.

Abstract: The invention relates to a respirator mask with hygienic protection. More specifically, the invention relates to a respirator face mask (2) which provides physiological protection, comprising: an oronasal face piece (10), a semi-flexible lip element (6) which is used to position the oronasal face piece (10) on the user's face (1), and hygienic protection means (4) which are removably-positioned at least partially inside the mask (2). The aforementioned removable protection means (4) comprise (i) a first part (4a) which provides hygienic protection and (ii) a second part (4b) which maintains the hygienic protection means (4) inside the mask (2), said second part (4b) co-operating elastically with the above-mentioned semi-flexible lip element (6) or the face piece (10).