Lysine; Diaminopimelic Acid; Threonine; Valine Patents (Class 435/115)
  • Method of producing L-lysine
    Publication number: 20030054506
    Abstract: The L-lysine-producing ability and the L-lysine-producing speed are improved in a coryneform bacterium harboring an aspartokinase in which feedback inhibition by L-lysine and L-threonine is substantially desensitized, by successively enhancing DNA coding for a dihydrodipicolinate reductase, DNA coding for a dihydrodipicolinate synthase, DNA coding for a diaminopimelate decarboxylase, and DNA coding for a diaminopimelate dehydrogenase.
    Type: Application
    Filed: August 23, 2002
    Publication date: March 20, 2003
    Applicant: AJINOMOTO CO. INC.
    Inventors: Seiko Otsuna, Masakazu Sugimoto, Masako Izui, Atsushi Hayakawa, Eiichi Nakano, Masaki Kobayashi, Yasuhiko Yoshihara, Tsuyoshi Nakamatsu
  • Fermentative production of L-lysine
    Publication number: 20030049805
    Abstract: The present invention provides Methylobacillus bacteria containing an aspartokinase gene and/or a dihydrodipicolinate synthase gene wherein the activities of these genes are insensitive to L-lysine feedback inhibition and methods of producing L-lysine by culturing the Methylobacillus bacteria.
    Type: Application
    Filed: October 22, 2002
    Publication date: March 13, 2003
    Applicant: AJINOMOTO CO. INC
    Inventors: Kazuo Nagase, Hisashi Yasueda, Shinichi Sugimoto
  • Corynebacterium glutamicum genes encoding metabolic pathway proteins
    Publication number: 20030049804
    Abstract: Isolated nucleic acid molecules, designated MP nucleic acid molecules, which encode novel MP proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing MP nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further provides isolated MP proteins, mutated MP proteins, fusion proteins, antigenic peptides and methods for the improvement of production of a desired compound from C. glutamicurn based on genetic engineering of MP genes in this organism.
    Type: Application
    Filed: December 22, 2000
    Publication date: March 13, 2003
    Inventors: Markus Pompejus, Burkhard Kroger, Hartwig Schroder, Oskar Zelder, Gregor Haberhauer, Jun-Won Kim, Heung-Shick Lee, Byung-Joon Hwang
  • Process for the production of L-amino acids by fermentation using coryneform bacteria
    Publication number: 20030044943
    Abstract: The invention relates to a process for the production of L-amino acids, in which the following steps are carried out:
    Type: Application
    Filed: April 9, 2002
    Publication date: March 6, 2003
    Inventors: Mike Farwick, Brigitte Bathe, Thomas Hermann, Achim Marx, Walter Pfefferle
  • Pyruvate carboxylase from Corynebacterium glutamicum
    Publication number: 20030027305
    Abstract: The present invention concerns an anaplerotic enzyme from Corynebacterium glutamicum which replenishes oxaloacetate consumed during lysine and glutamic acid production in industrial fermentations. In particular, isolated nucleic acid molecules are provided encoding the pyruvate carboxylase protein. Pyruvate carboxylase polypeptides are also provided.
    Type: Application
    Filed: January 15, 2002
    Publication date: February 6, 2003
    Applicant: Archer-Daniels-Midland Company
    Inventors: Anthony J. Sinskey, Philip A. Lessard, Laura B. Willis
  • Process for the fermentative preparation of L-amino acids using strains of the enterobacteriaceae family
    Publication number: 20030017554
    Abstract: A process for the fermentative preparation of an L-amino acid which entails the steps of:
    Type: Application
    Filed: February 19, 2002
    Publication date: January 23, 2003
    Inventors: Mechthild Rieping, Georg Thierbach
  • Nucleotide sequences coding for the lrp gene
    Publication number: 20030017555
    Abstract: The present invention relates to an isolated polynucleotide coding for the lrp gene and to a process for the fermentative production of L-amino acids by altering the expression of this gene.
    Type: Application
    Filed: April 30, 2002
    Publication date: January 23, 2003
    Inventors: Brigitte Bathe, Jorn Kalinowski, Alfred Puhler, Bettina Mockel, Walter Pfefferle
  • Nucleotide sequences which code for the pck gene
    Publication number: 20030003548
    Abstract: The invention relates to isolated nucleotide sequences from Coryneform bacteria which code for the pck gene encoding the enzyme phosphoenol pyruvate carboxykinase (PEP carboxykinase). The invention also relates a process for the fermentative preparation of L-amino acids, in particular L-lysine, L-threonine, and L-glutamate by attenuation of the pck gene.
    Type: Application
    Filed: May 6, 2002
    Publication date: January 2, 2003
    Inventors: Bernhard Eikmanns, Christian Riedel, Hermann Sahm, Bettina Mockel
  • Nucleotide sequences which code for the luxS gene
    Publication number: 20020182689
    Abstract: The invention relates to an isolated polynucleotide comprising a polynucleotide sequence chosen from the group consisting of
    Type: Application
    Filed: August 1, 2001
    Publication date: December 5, 2002
    Inventors: Brigitte Bathe, Caroline Kreutzer, Achim Marx, Walter Pfefferle
  • Process for the fermentative preparation of L-amino acids using coryneform bacteria
    Publication number: 20020168732
    Abstract: The invention relates to a process for the preparation of L-amino acids in which the following steps are carried out,
    Type: Application
    Filed: March 26, 2001
    Publication date: November 14, 2002
    Inventors: Bettina Moeckel, Thomas Hermann, Walter Pfefferle
  • Method of producing target substance by fermentation
    Publication number: 20020155556
    Abstract: In a method for producing a target substance by utilizing a microorganism comprising culturing a bacterium belonging to the genus Escherichia in a medium to produce and accumulate the target substance in the medium or cells of the bacterium and collecting the target substance, a strain in which an RMF protein does not function normally in its cell due to, for example, disruption of rmf gene on chromosome, is used to improve production efficiency or production rate of a useful substance such as L-amino acid, protein and nucleic acid.
    Type: Application
    Filed: December 21, 2001
    Publication date: October 24, 2002
    Applicant: AJINOMOTO CO., INC
    Inventors: Akira Imaizumi, Yoshihiro Usuda, Shinichi Sugimoto
  • Nucleotide sequences which code for the rpsL gene
    Publication number: 20020155557
    Abstract: An isolated polynucleotide comprising a polynucleotide sequence chosen from the group consisting of
    Type: Application
    Filed: February 15, 2002
    Publication date: October 24, 2002
    Applicant: DEGUSSA AG
    Inventors: Bettina Moeckel, Brigitte Bathe, Stefan Hans, Caroline Kreutzer, Thomas Hermann, Walter Pfefferle, Michael Binder
  • Yeast transport isoforms
    Publication number: 20020155192
    Abstract: A method is provided for modulating transport of an oxodicarboxylate across the mitochondrial membrane of a yeast which method comprises modulating in said yeast the activity of one or more Odc1p and/or Odc2p yeast mitochondrial transport polypeptides.
    Type: Application
    Filed: January 11, 2002
    Publication date: October 24, 2002
    Inventors: John Walker, Michael Runswick, Ferdinando Palmieri, Luigi Palmieri, Gennaro Agrimi
  • Nucleotide sequences which code for the pgsA2 gene
    Publication number: 20020155555
    Abstract: The invention relates to a genetically modified coryneform bacterium, the pgsA2 gene of which is amplified, and an isolated polynucleotide which codes for CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase from coryneform bacteria, and also a method for the fermentative preparation of L-amino acids with amplification of the pgsA2 gene in the bacteria and the use of the polynucleotide as a primer or hydridization probe.
    Type: Application
    Filed: May 16, 2001
    Publication date: October 24, 2002
    Inventors: Madhavan Nampoothiri K., Bettina Mockel, Walter Pfefferle, Lothar Eggeling, Hermann Sahm
  • Nucleotide sequences which code for the chrA gene
    Publication number: 20020155554
    Abstract: The invention relates to an isolated polynucleotide comprising a polynucleotide sequence chosen from the group consisting of
    Type: Application
    Filed: April 4, 2001
    Publication date: October 24, 2002
    Inventors: Brigitte Bathe, Natalie Schischka, Achim Marx, Walter Pfefferle
  • Nucleotide sequences coding for the ccpA1 gene
    Publication number: 20020151001
    Abstract: The present invention provides isolated polynucleotides containing a polynucleotide sequence which is:
    Type: Application
    Filed: August 27, 2001
    Publication date: October 17, 2002
    Applicant: DEGUSSA AG
    Inventors: Bettina Moeckel, Caroline Kreutzer
  • Nucleotide sequences coding for the sigC gene
    Publication number: 20020146782
    Abstract: The invention relates to an isolated polynucleotide having a polynucleotide sequence which codes for the sigC gene, and a host-vector system having a coryneform host bacterium in which the sigC gene is present in attenuated form and a vector which carries at least the sigC gene according to SEQ ID No 1, and the use of polynucleotides which comprise the sequences according to the invention as hybridization probes.
    Type: Application
    Filed: August 30, 2001
    Publication date: October 10, 2002
    Inventors: Brigitte Bathe, Stephan Hans, Mike Farwick, Thomas Hermann, Walter Pfefferle
  • Nucleotide sequences which code for the atr43 gene
    Publication number: 20020142404
    Abstract: The invention relates to an isolated polynucleotide having a polynucleotide sequence which codes for the atr43 gene, and a host-vector system having a coryneform host bacterium in which the atr43 gene is present in attenuated form and a vector which carries at least the atr43 gene according to SEQ ID No 1, and the use of polynucleotides which comprise the sequences according to the invention as hybridization probes.
    Type: Application
    Filed: September 14, 2001
    Publication date: October 3, 2002
    Inventors: Mike Farwick, Klaus Huthmacher, Walter Pfefferle
  • Process for the preparation of L-amino acids by fermentation and nucleotide sequences coding for the accDA gene
    Publication number: 20020142405
    Abstract: The invention relates to nucleotide sequences coding for the accDA gene and to a process for the preparation of L-amino acids, especially L-lysine, by fermentation using corynebacteria in which the accDA gene is amplified.
    Type: Application
    Filed: December 21, 2001
    Publication date: October 3, 2002
    Inventors: Yvonne Tilg, Bernd Eikmanns, Lothar Eggeling, Hermann Sahm, Bettina Mockel
  • Nucleotide sequences which code for the cstA gene
    Publication number: 20020137912
    Abstract: The invention relates to an isolated polynucleotide having a polynucleotide sequence which codes for the cstA gene, and a host-vector system having a coryneform host bacterium in which the cstA gene is present in attenuated form and a vector which carries at least the cstA gene according to SEQ ID No 1, and the use of polynucleotides which comprise the sequences according to the invention as hybridization probes.
    Type: Application
    Filed: August 24, 2001
    Publication date: September 26, 2002
    Inventors: Bettina Mockel, Achim Marx, Walter Pfefferle, Mike Farwick, Thomas Hermann
  • Process for the fermentative preparation of metabolic products and for the nucleotide sequences encoding for the sod gene
    Publication number: 20020137151
    Abstract: The invention provides nucleotide sequences encoding for the sod gene and a process for the fermentative preparation of nucleotides, vitamins and L-amino acids, in particular L-lysine, using coryneform bacteria in which the sod gene is amplified.
    Type: Application
    Filed: March 28, 2001
    Publication date: September 26, 2002
    Applicant: Degussa-Huls Aktiengesellschaft
    Inventors: Muriel Merkamm, Armel Guyonvarch, Achim Marx
  • Nucleotide sequences which code for the zwa1 gene
    Publication number: 20020127663
    Abstract: The invention relates to an isolated polynucleotide comprising a polynucleotide sequence chosen from the group consisting of
    Type: Application
    Filed: December 8, 2000
    Publication date: September 12, 2002
    Inventors: Bettina Mockel, Walter Pfefferle, Achim Marx, Jorn Kalinowski, Brigitte Bathe, Alfred Puhler
  • Method for producing high concentration carbon dioxide product
    Publication number: 20020115132
    Abstract: A method for producing carbon dioxide in a high concentration suitable for direct usage or more facile further purification wherein microbial growth and fermentation of one or more carbonaceous materials are carried out with the use of defined high concentration oxidant fluid which is provided to a fermentation broth to provide oxygen in a defined limited amount.
    Type: Application
    Filed: April 3, 2002
    Publication date: August 22, 2002
    Inventors: Chris Ka Kee Ho, Dan Grunwald
  • Nucleotide sequences coding for the cysQ gene
    Publication number: 20020115162
    Abstract: The invention relates to polynucleotide sequences from coryneform bacteria coding for the cysQ gene and a process for the fermentative preparation of amino acids using bacteria in which the endogenous cysQ gene is enhanced, as well as to the use of polynucleotides containing the sequences according to the invention as hybridization probes.
    Type: Application
    Filed: November 14, 2001
    Publication date: August 22, 2002
    Inventors: Mike Farwick, Klaus Huthmacher, Brigitte Bathe, Walter Pfefferle
  • Nucleotide sequences which code for the truB gene
    Publication number: 20020115160
    Abstract: The invention relates to an isolated polynucleotide having a polynucleotide sequence which codes for the truB gene, and a host-vector system having a coryneform host bacterium in which the truB gene is present in attenuated form and a vector which carries at least the truB gene according to SEQ ID No 1, and the use of polynucleotides which comprise the sequences according to the invention as hybridization probes.
    Type: Application
    Filed: September 27, 2001
    Publication date: August 22, 2002
    Inventors: Mike Farwick, Klaus Huthmacher, Walter Pfefferle, Brigitte Bathe
  • Nucleotide sequences coding for the ATR61protein
    Publication number: 20020115159
    Abstract: The invention provides nucleotide sequences from Coryneform bacteria which code for the Atr61 protein and a process for the fermentative preparation of amino acids using bacteria in which the atr61 gene is enhanced.
    Type: Application
    Filed: September 17, 2001
    Publication date: August 22, 2002
    Applicant: DEGUSSA AG
    Inventors: Mike Farwick, Klaus Huthmacher, Walter Pfefferle
  • Nucleotide sequences which code for the deaD gene
    Publication number: 20020115161
    Abstract: The invention relates to an isolated polynucleotide having a polynucleotide sequence which codes for the deaD gene, and a host-vector system having a coryneform host bacterium in which the deaD gene is present in attenuated form and a vector which carries at least the deaD gene according to SEQ ID No 1, and the use of polynucleotides which comprise the sequences according to the invention as hybridization probes.
    Type: Application
    Filed: September 27, 2001
    Publication date: August 22, 2002
    Inventors: Mike Farwick, Klaus Huthmacher, Jennifer Brehme, Walter Pfefferle
  • Nucleotide sequences which code for the metY gene
    Publication number: 20020110878
    Abstract: An isolated polynucleotide comprising a polynucleotide sequence selected from the group consisting of
    Type: Application
    Filed: August 2, 2001
    Publication date: August 15, 2002
    Applicant: DEGUSSA AG
    Inventors: Bettina Moeckel, Walter Pfefferle, Klaus Huthmacher, Christian Rueckert, Joern Kalinowski, Alfred Puehler, Michael Binder, Dieter Greissinger, Georg Thierbach
  • Nucleotide sequences coding for the ppgK gene
    Publication number: 20020110879
    Abstract: The invention relates to an isolated polynucleotide having a polynucleotide sequence which codes for the ppgK gene, and a host-vector system having a coryneform host bacterium in which the ppgK gene is present in attenuated form and a vector which carries at least the ppgK gene according to SEQ ID No 1, and the use of polynucleotides which comprise the sequences according to the invention as hybridization probes
    Type: Application
    Filed: September 24, 2001
    Publication date: August 15, 2002
    Inventors: Brigitte Bathe, Monika Martens, Thomas Hermann
  • Nucleotide sequences which code for the gorA gene
    Publication number: 20020106758
    Abstract: The invention relates to an isolated polynucleotide having a polynucleotide sequence which codes for the gorA gene, and a host-vector system having a coryneform host bacterium in which the gorA gene is present in attenuated form and a vector which carries at least the gorA gene according to SEQ ID No 1, and the use of polynucleotides which comprise the sequences according to the invention as hybridization probes.
    Type: Application
    Filed: September 6, 2001
    Publication date: August 8, 2002
    Inventors: Mike Farwick, Klaus Huthmacher, Walter Pfefferle, Achim Marx
  • Novel nucleotide sequences encoding the zwa2 gene
    Publication number: 20020106748
    Abstract: The invention provides novel isolated polynucleotides containing a polynucleotide sequence chosen from the group
    Type: Application
    Filed: December 4, 2000
    Publication date: August 8, 2002
    Inventors: Bettina Mockel, Anke Weissenborn, Walter Pfefferle, Achim Marx, Alfred Puhler, Jorn Kalinowski, Brigitte Bathe, Nicole Dusch
  • Nucleotide sequences which code for the dep34 gene
    Publication number: 20020106757
    Abstract: The invention relates to an isolated polynucleotide having a polynucleotide sequence which codes for the dep34 gene, and a host-vector system having a coryneform host bacterium in which the dep34 gene is present in attenuated form and a vector which carries at least the dep34 gene according to SEQ ID No 1, and the use of polynucleotides which comprise the sequences according to the invention as hybridization probes.
    Type: Application
    Filed: September 6, 2001
    Publication date: August 8, 2002
    Inventors: Mike Farwick, Klaus Huthmacher, Walter Pfefferle, Thomas Hermann, Brigitte Bathe
  • Nucleotide sequences which code for the dps gene
    Publication number: 20020106760
    Abstract: The invention relates to an isolated polynucleotide having a polynucleotide sequence which codes for the dps gene, and a host-vector system having a coryneform host bacterium in which the dps gene is present in attenuated form and a vector which carries at least the dps gene according to SEQ ID No 1, and the use of polynucleotides which comprise the sequences according to the invention as hybridization probes.
    Type: Application
    Filed: September 19, 2001
    Publication date: August 8, 2002
    Inventors: Brigitte Bathe, Caroline Kreutzer, Mechthild Rieping, Achim Marx, Mike Farwick, Walter Pfefferle
  • Nucleotide sequences coding for the dctA gene
    Publication number: 20020106759
    Abstract: The invention relates to an isolated polynucleotide having a polynucleotide sequence which codes for the dctA gene, and a host-vector system having a coryneform host bacterium in which the dctA gene is present in attenuated form and a vector which carries at least the dctA gene according to SEQ ID No 1, and the use of polynucleotides which comprise the sequences according to the invention as hybridization probes.
    Type: Application
    Filed: September 14, 2001
    Publication date: August 8, 2002
    Inventors: Mike Farwick, Klaus Huthmacher, Brigitte Bathe, Thomas Hermann, Walter Pfefferle
  • Nucleotide sequences which codes for the alr gene
    Publication number: 20020106754
    Abstract: The invention relates to an isolated polynucleotide having a polynucleotide sequence which codes for the alr gene, and a host-vector system having a coryneform host bacterium in which the air gene is present in attenuated form and a vector which carries at least the air gene according to SEQ ID No 1, and the use of polynucleotides which comprise the sequences according to the invention as hybridization probes.
    Type: Application
    Filed: July 23, 2001
    Publication date: August 8, 2002
    Inventors: Andreas Tauch, Michael Binder, Walter Pfefferle, Georg Thierbach, Jorn Kalinowski, Alfred Puhler
  • Nucleotide sequences coding for the sigM gene
    Publication number: 20020106755
    Abstract: The invention relates to an isolated polynucleotide having a polynucleotide sequence which codes for the sigM gene, and a host-vector system having a coryneform host bacterium in which the sigM gene is present in attenuated form and a vector which carries at least the sigM gene according to SEQ ID No 1, and the use of polynucleotides which comprise the sequences according to the invention as hybridization probes.
    Type: Application
    Filed: August 31, 2001
    Publication date: August 8, 2002
    Inventors: Brigitte Bathe, Christine Bastuck, Mike Farwick, Thomas Hermann, Walter Pfefferle
  • Nucleotide sequences which code for the sigH gene
    Publication number: 20020106756
    Abstract: The invention relates to an isolated polynucleotide having a polynucleotide sequence which codes for the sigh gene, and a host-vector system having a coryneform host bacterium in which the sigh gene is present in attenuated form and a vector which carries at least the sigh gene according to SEQ ID No 1, and the use of polynucleotides which comprise the sequences according to the invention as hybridization probes.
    Type: Application
    Filed: August 31, 2001
    Publication date: August 8, 2002
    Inventors: Brigitte Bathe, Indra Schroder, Mechthild Rieping, Achim Marx, Mike Farwick, Walter Pfefferle, Thomas Hermann
  • Nucleotide sequences coding for the thyA gene
    Publication number: 20020107379
    Abstract: The invention relates to an isolated polynucleotide having a polynucleotide sequence which codes for the thyA gene, and a host-vector system having a coryneform host bacterium in which the thyA gene is present in attenuated form and a vector which carries at least the thyA gene according to SEQ ID No 1, and the use of polynucleotides which comprise the sequences according to the invention as hybridization probes
    Type: Application
    Filed: September 18, 2001
    Publication date: August 8, 2002
    Inventors: Achim Marx, Natalie Schischka, Brigitte Bathe, Mike Farwick
  • Process for the purification of 1,3-propanediol from a fermentation medium
    Patent number: 6428992
    Abstract: The present invention relates to a process for the purification of 1,3-propanediol from a fermentation medium of a 1,3-propanediol-producing microorganism, comprising 1,3-propanediol and fermentation coproducts consisting at least of glycerol, wherein the 1,3-propanediol-producing microorganism is separated from the other components of the fermentation medium to give a clarified aqueous solution, clarified aqueous solution is passed over a cation exchange resin to give at least one fraction comprising purified 1,3-propanediol and at least one fraction comprising the fermentation coproducts, and the 1,3-propanediol is recovered.
    Type: Grant
    Filed: November 14, 2000
    Date of Patent: August 6, 2002
    Assignee: Roquette Freres
    Inventors: Jean-Michel Roturier, Catherine Fouache, Elie Berghmans
  • Novel nucleotide sequences coding for the cls gene
    Publication number: 20020102667
    Abstract: This invention relates to a genetically modified coryneform bacterium, the cls gene of which is amplified, and to an isolated polynucleotide, which codes for cardiolipin synthase from coryneform bacteria and to a process for the fermentative production of L-amino acids with amplification of the cls gene in the bacteria and to the use of the polynucleotide as a primer or hybridization probe.
    Type: Application
    Filed: May 4, 2001
    Publication date: August 1, 2002
    Inventors: Madhavan Nampoothiri K., Bettina Mockel, Walter Pfefferle, Lothar Eggeling, Hermann Sahm
  • Nucleotide sequences which code for the cobW gene
    Publication number: 20020102668
    Abstract: The invention relates to an isolated polynucleotide having a polynucleotide sequence which codes for the cobW gene, and a host-vector system having a coryneform host bacterium in which the cobW gene is present in attenuated form and a vector which carries at least the cobW gene according to SEQ ID No 1, and the use of polynucleotides which comprise the sequences according to the invention as hybridization probes.
    Type: Application
    Filed: September 6, 2001
    Publication date: August 1, 2002
    Inventors: Mike Farwick, Klaus Huthmacher, Natalie Schischka, Walter Pfefferle
  • Nucleotide sequences which code for the msiK gene
    Publication number: 20020103357
    Abstract: The invention relates to an isolated polynucleotide having a polynucleotide sequence which codes for the MsiK gene, and a host-vector system having a coryneform host bacterium in which the MsiK gene is present in attenuated form and a vector which carries at least the MsiK gene according to SEQ ID No 1, and the use of polynucleotides which comprise the sequences according to the invention as hybridization probes.
    Type: Application
    Filed: September 26, 2001
    Publication date: August 1, 2002
    Inventors: Brigitte Bathe, Natalie Schischka, Mike Farwick, Walter Pfefferle
  • Nucleotide sequences which code for the clpC gene
    Publication number: 20020102669
    Abstract: The invention relates to an isolated polynucleotide having a polynucleotide sequence which codes for the clpC gene, and a host-vector system having a coryneform host bacterium in which the clpC gene is present in attenuated form and a vector which carries at least the clpC gene according to SEQ ID No 1, and the use of polynucleotides which comprise the sequences according to the invention as hybridization probes.
    Type: Application
    Filed: September 10, 2001
    Publication date: August 1, 2002
    Inventors: Mike Farwick, Klaus Huthmacher, Brigitte Bathe, Walter Pfefferle, Mechthild Rieping
  • Nucleotide sequences which code for the menE gene
    Publication number: 20020102663
    Abstract: The invention relates to an isolated polynucleotide comprising a polynucleotide sequence chosen from the group consisting of
    Type: Application
    Filed: April 16, 2001
    Publication date: August 1, 2002
    Inventors: Mike Farwick, Klaus Huthmacher, Achim Marx, Walter Pfefferle
  • Sequences which code for the sigE gene
    Publication number: 20020103356
    Abstract: The invention relates to an isolated polynucleotide comprising a polynucleotide sequence chosen from the group consisting of
    Type: Application
    Filed: August 24, 2001
    Publication date: August 1, 2002
    Inventors: Bettina Mockel, Thomas Hermann, Mike Farwick, Michael Binder, Walter Pfefferle
  • Nucleotide sequences encoding the ptsH gene
    Publication number: 20020094554
    Abstract: The invention relates to an isolated polynucleotide containing a polynucleotide sequence selected from the group comprising
    Type: Application
    Filed: January 8, 2001
    Publication date: July 18, 2002
    Inventors: Mike Farwick, Bettina Mockel, Walter Pfefferle
  • Nucleotide sequences coding for the ndkA gene
    Publication number: 20020090685
    Abstract: The invention relates to an isolated polynucleotide having a polynucleotide sequence which codes for the ndkA gene, and a host-vector system having a coryneform host bacterium in which the ndkA gene is present in attenuated form and a vector which carries at least the ndkA gene according to SEQ ID No 1, and the use of polynucleotides which comprise the sequences according to the invention as hybridization probes
    Type: Application
    Filed: September 19, 2001
    Publication date: July 11, 2002
    Inventors: Brigitte Bathe, Christine Bastuck, Achim Marx, Thomas Hermann
  • Nucleotide sequences encoding the ptsH gene
    Publication number: 20020090700
    Abstract: The invention relates to an isolated polynucleotide containing a polynucleotide sequence selected from the group comprising
    Type: Application
    Filed: March 29, 2001
    Publication date: July 11, 2002
    Inventors: Mike Farwick, Bettina Mockel, Walter Pfefferle
  • L-lysine-producing corynebacteria and process for the preparation of L-lysine
    Publication number: 20020086371
    Abstract: The invention relates to L-lysine-producing strains of corynebacteria with enhanced lysE gene (lysine export carrier gene), in which strains additional genes chosen from the group comprising the dapA gene (dihydrodipicolinate synthase gene), the lysC gene (aspartate kinase gene), the dapB gene (dihydrodipicolinate reductase gene) and the pyc gene, but especially the dapA gene and the lysC gene (aspartate kinase gene), are enhanced and, in particular, over-expressed, and to a process for the preparation of L-lysine.
    Type: Application
    Filed: March 8, 2001
    Publication date: July 4, 2002
    Applicant: Degussa-Huls Aktiengesellschaft
    Inventors: Caroline Kreutzer, Stephan Hans, Mechthild Rieping, Bettina Mockel, Walter Pfefferle, Lothar Eggeling, Hermann Sahm, Miroslav Patek
  • Nucleotide sequences which code for the cysD, cysN, cysK, cysE and cysH genes
    Publication number: 20020086373
    Abstract: Nucleotide sequences from coryneform bacteria which code for the cysD, cysN, cysK, cysE and cysH genes and a process for the fermentative preparation of amino acids using bacteria in which the genes mentioned are enhanced, a process for the fermentative preparation of L-amino acids using coryneform bacteria in which at least the cysD gene, the cysN gene, the cysK gene, the cysE gene and/or the cysH gene is present in enhanced form, and the use of polynucleotides which contain the sequences according to the invention as hybridization probes and a process for the preparation of an L-methionine-containing animal feedstuffs additive from fermentation broths.
    Type: Application
    Filed: September 26, 2001
    Publication date: July 4, 2002
    Applicant: DEGUSSA AG
    Inventors: Mike Farwick, Klaus Huthmacher, Natalie Schischka, Brigitte Bathe, Walter Pfefferle, Michael Binder, Dieter Greissinger, Georg Thierbach