Polycyclo Ring System Having The Five-membered Hetero Ring As One Of The Cyclos Patents (Class 548/416)
  • Patent number: 5676923
    Abstract: Diethylenetriaminepentaacetic acid monoamide derivatives, their complexes and complex salts, containing an element of atomic numbers 21-29, 31, 32, 39, 42-44, 49 or 57-83, pharmaceutical agents containing these compounds, their use as contrast media and process for their production.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: October 14, 1997
    Assignee: Schering Aktiengesellschaft
    Inventors: Johannes Platzek, Ulrich Niedballa, Peter Mareski, Bernd Raduchel, Hanns-Joachim Weinmann, Andreas Muhler, Bernd Misselwitz
  • Patent number: 5677330
    Abstract: A family of compounds has been found to be useful for right-shifting hemoglobin towards a low oxygen affinity state. The effect has particular application in a wide variety of treatments including hypoxia, hypothermia, ischemia, stroke, ARDS, COPD, surgical blood loss, acute nonvolemic hemodilutions, wounds, diabetic ulcers, chronic leg ulcers, pressure sores, tissue transplants, and sepsis. The compounds are capable of acting on hemoglobin in whole blood.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: October 14, 1997
    Assignees: The Center for Innovative Technology, Allos Therapeutics, Inc.
    Inventors: Donald J. Abraham, Michael Gerber
  • Patent number: 5665877
    Abstract: The present invention provides a novel synthesis of the compounds of Formula (I): ##STR1## The compounds are produced in high yield and without utilizing expensive chromatographic separations. The synthesis is particularly advantageous because it is stereoselective.
    Type: Grant
    Filed: May 17, 1996
    Date of Patent: September 9, 1997
    Assignee: Eli Lilly and Company
    Inventors: Margaret M. Faul, Michael R. Jirousek, Leonard L. Winneroski, II
  • Patent number: 5654427
    Abstract: The invention features a method of treating a pathological condition of the prostate gland, e.g., benign prostatic hypertrophy or prostate cancer, in a mammal, said method comprising administering to said mammal a therapeutic amount of the indolocarbazole compound K-252a or a preferred derivative thereof. The invention also includes novel derivatives of K-252a.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: August 5, 1997
    Assignees: Kyowa Hakko Kogyo Co., Ltd., Cephalon, Inc.
    Inventors: Craig A. Dionne, Patricia C. Contreras, Chikara Murakata
  • Patent number: 5648375
    Abstract: Allosteric hemoglobin modifier compound activity on p50 is potentiated by using the compound in combination with a hydrophobic compound such as an anesthetic.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: July 15, 1997
    Assignee: Virginia Commonwealth University
    Inventor: Donald J. Abraham
  • Patent number: 5618809
    Abstract: N-alkanoyl derivatives of staurospodne represented by the formula I ##STR1## wherein R.sub.a and R.sub.b are each H or ##STR2## wherein R.sub.1 and R.sub.2 are independently H or --OH or --OCH.sub.3 and R.sub.3 is OH, NHCH.sub.3, NCH COCH.sub.3 or NHCOCH.sub.3 and R.sub.4 is OH or H and, stereochemical isomers thereof with the provisos that (1) when R.sub.a and R.sub.b .dbd.A, and R.sub.1.dbd.H.sub.2 or OH R.sub.3 is not NHCH.sub.3 ; (2) when R.sub.a and R.sub.b.dbd. B, then R.sub.1 .dbd.R.sub.4 .dbd.OH or R.sub.1 .dbd.R.sub.4 .dbd.H; (3) when R.sub.a .dbd.R.sub.b .dbd.H R.sub.1 .dbd.--OCH.sub.3, and (4) when R.sub.a and R.sub.b .dbd.A, and R.sub.1 .dbd.H and R.sub.2 .dbd.OCH.sub.3, then R3 is not and ##STR3## pharmaceutical compositions thereof useful for inhibiting myosin light chain kinase, protein kinase C or tumor cell proliferation as well as producing an antihypertensive effect and an anti-inflammatory effect in warm-blood animals such as man are disclosed.
    Type: Grant
    Filed: February 27, 1995
    Date of Patent: April 8, 1997
    Assignee: Schering Corporation
    Inventors: Ellen B. Barrabee, Ann C. Horan, Frank A. Gentile, Mahesh G. Patel
  • Patent number: 5616724
    Abstract: Disclosed in this patent document are synthetic, biologically active molecules referred to as fused pyrrolo[2,3-c]carbazole-6-ones. These molecules are represented by the following general formulae: ##STR1## Methods for making and using the fused pyrrolo[2,3-c]carbazole-6-ones are also disclosed.
    Type: Grant
    Filed: February 21, 1996
    Date of Patent: April 1, 1997
    Assignee: Cephalon, Inc.
    Inventors: Robert L. Hudkins, James L. Diebold, Ernest Knight, Jr.
  • Patent number: 5599957
    Abstract: An optically active manganese complex of the formula I.sub.a, I.sub.b, I.sub.c and I.sub.d ##STR1## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 independently represent hydrogen atom, C.sub.1 -.sub.4 alkyl group, phenyl group which may be substituted by a halogen atom, C.sub.1 -.sub.4 alkyl group, C.sub.1 -.sub.4 alkoxyl group, cyano group or nitro group; and any two of R.sup.1, R.sup.2, R.sup.3 and R.sup.4 together form a C.sub.4 -.sub.8 ring, X.sup.- represents a counter anion which may form a salt, Y represents hydrogen atom, halogen atom, C.sub.1 -.sub.4 alkyl group, C.sub.1 -.sub.4 alkoxyl group, nitro group or cyano group, R represents hydrogen atom, C.sub.1 -.sub.4 alkyl group, phenyl group which may be substituted by halogen atom, C.sub.1 -.sub.4 alkyl group or C.sub.1 -.sub.4 alkoxyl group, or substituted silyl group and a process for producing epoxy compounds using the complex as a catalyst.
    Type: Grant
    Filed: May 30, 1995
    Date of Patent: February 4, 1997
    Assignee: Nissan Chemical Industries, Ltd.
    Inventors: Tsutomu Katsuki, Ryo Irie, Hidehiko Sasaki
  • Patent number: 5556959
    Abstract: A chemical compound of the following formula is disclosed ##STR1## where R is one of H, trityl, 4-0-monomethoxytrityl, 4,4'-O-dimethoxytrityl, or acyl groups and R may be used as a protecting group or is an H; R.sup.1 is a phosphoramidite; R.sup.11 is one of H or lower alkyl groups; R.sup.111 is one of H or lower alkyl groups; R.sup.4 is one of H, lower alkyl, acyl, or (CH.sub.2).sub.p COO(CH.sub.2).sub.q CH.sub.3 where p is an integer from 0 to 4 and q is an integer from 0 to 4; R.sup.5 is one of H, lower alkyl, acyl, or (CH.sub.2).sub.p COO(CH.sub.2).sub.q CH.sub.3 where p is an integer from 0 to 4 and q is an integer from 0 to 4; n is an integer from 0 to 10; m is an integer from 0 to 10; and r is 1, 2, or 3.
    Type: Grant
    Filed: June 24, 1994
    Date of Patent: September 17, 1996
    Assignee: Pharmacia P-L Biochemicals Inc.
    Inventors: Charles K. Brush, Eric D. Anderson
  • Patent number: 5547976
    Abstract: The present invention relates to indolopyrolocarbazole derivatives, to their use in methods of treatment or prophylaxis of at least one viral infection or cardiovascular diseases; and pharmaceutical formulations containing such derivatives.
    Type: Grant
    Filed: August 23, 1994
    Date of Patent: August 20, 1996
    Assignee: Burroughs Wellcome Co.
    Inventors: Martin J. Slater, George S. Cockerill, Edward Littler, Clive L. Yeates
  • Patent number: 5543436
    Abstract: The present invention relates to novel carbazole derivatives corresponding to the formula: ##STR1## in which R.sub.1 is H, benzyl or alkyl; R.sub.2 and R.sub.3 are a carbethoxy, acetyl, nitrile, ##STR2## with R.sub.2 =R.sub.3 other than H, or R.sub.2 and R.sub.3 form the following ring systems: ##STR3## R.sub.4 is H, Cl, methoxy, nitrile or nitro; R.sub.5, R.sub.7 and R.sub.8 are H or methoxy; R.sub.6 is H or methyl; with the proviso that if R.sub.2 and R.sub.3 form the ring system (c), at least one of R.sub.1, R.sub.4, R.sub.5, R.sub.6, R.sub.7 and R.sub.8 does not denote H.The invention also relates to the use in cosmetics of these novel compounds as pigments, and in particular in cosmetic compositions intended for the treatment and/or the coloration of keratinous substances.
    Type: Grant
    Filed: January 10, 1995
    Date of Patent: August 6, 1996
    Assignee: L'Oreal
    Inventors: Michel Hocquaux, Michel Philippe
  • Patent number: 5516771
    Abstract: The invention features a method of treating a pathological condition of the prostate gland, e.g., benign prostatic hypertrophy or prostate cancer, in a mammal, said method comprising administering to said mammal a therapeutic amount of the indolocarbazole compound K-252a or a preferred derivative thereof. The invention also includes novel derivatives of K-252a.
    Type: Grant
    Filed: May 27, 1994
    Date of Patent: May 14, 1996
    Assignees: Cephalon, Inc., Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Craig A. Dionne, Patricia C. Contreras, Chikara Murakata
  • Patent number: 5489608
    Abstract: The present invention provides indolocarbazole derivatives of the formula ##STR1## as well as the regioisomeric mixtures thereof, pharmacologically acceptable salts thereof, processes for the preparation thereof, and pharmaceutical compositions containing them for the treatment and/or prophylaxis of heart and blood vessel diseases, such as thromboses, arterioscleroses, hypertonias, of bronchopulmonary diseases, inflammatory processes, allergies, cancers and degenerative damage of the central nervous system, and for the treatment of viral diseases.
    Type: Grant
    Filed: February 2, 1995
    Date of Patent: February 6, 1996
    Assignee: Goedecke Aktiengesellschaft
    Inventors: Jurgen Kleinschroth, Johannes Hartenstein, Christoph Schachtele, Claus Rudolph
  • Patent number: 5468872
    Abstract: Functional K-252a derivatives are used to enhance trk phosphorylation and to potentiate the activity of neurotrophin-3 (NT-3). These compounds can be used to treat neurological disorders, alone or in combination with NT-3.
    Type: Grant
    Filed: September 16, 1993
    Date of Patent: November 21, 1995
    Assignees: Cephalon, Inc., Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Marcie A. Glicksman, David P. Rotella, Nicola Neff, Chikara Murakata
  • Patent number: 5461146
    Abstract: The invention features novel derivatives of K-252a, as well as novel bis-N-substituted derivatives of staurosporine. Also, a method for treating diseased neuronal cells involving the administration of either the novel staurosporine derivatives or specified functional derivatives of K-252a.
    Type: Grant
    Filed: July 22, 1993
    Date of Patent: October 24, 1995
    Assignees: Cephalon, Inc., Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Michael E. Lewis, James C. Kauer, Nicola Neff, Jill Roberts-Lewis, Chikara Murakata, Hiromitsu Saito, Yuzuru Matsuda, Marcie A. Glicksman
  • Patent number: 5432191
    Abstract: A family of compounds has been found to be useful for right-shifting hemoglobin towards a low oxygen affinity state. The compounds are capable of acting on hemoglobin in whole blood. In addition, the compounds can maintain the oxygen affinity in blood during storage and can restore the oxygen affinity of outdated blood.
    Type: Grant
    Filed: July 30, 1993
    Date of Patent: July 11, 1995
    Assignee: The Center for Innovative Technology
    Inventors: Donald J. Abraham, Mona Mahran, Ahmed Mehanna, Ramnarayan Randad, Gajanan S. Joshi, Jayashree Panikker
  • Patent number: 5420314
    Abstract: An optically active manganese complex of the formula I or I': ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, and R.sup.4 independently represent hydrogen atom, C.sub.1 -C.sub.4 alkyl group, phenyl group which may be substituted by a halogen atom, C.sub.1 -C.sub.4 alkyl group, C.sub.1 -C.sub.4 alkoxyl group, cyano group or nitro group; and any two of R.sup.1, R.sup.2, R.sup.3 and R.sup.4 together form the C.sub.4 -C.sub.8 ring, X.sup.- represents a counter anion which may form a salt, Y represents hydrogen atom, halogen atom, C.sub.1 -C.sub.4 alkyl group, C.sub.1 -C.sub.4 alkoxyl group, nitro group or cyano group, R represents hydrogen atom, C.sub.1 -C.sub.4 alkyl group, phenyl group which may be substituted by halogen atom, C.sub.1 -C.sub.4 alkyl group or C.sub.1 -C.sub.4 alkoxyl group, or substituted silyl group and a process for producing epoxy compounds using the complex as a catalyst.
    Type: Grant
    Filed: March 14, 1994
    Date of Patent: May 30, 1995
    Assignee: Nissan Chemical Industries, Ltd.
    Inventors: Tsutomu Katsuki, Ryo Irie, Hidehiko Sasaki
  • Patent number: 5290803
    Abstract: A family of compounds has been found to be useful for right-shifting hemoglobin towards a low oxygen affinity state. The compounds are capable of acting on hemoglobin in whole blood. In addition, the compounds can maintain the oxygen affinity in blood during storage and can restore the oxygen affinity of outdated blood.
    Type: Grant
    Filed: January 19, 1993
    Date of Patent: March 1, 1994
    Assignee: The Center of Innovative Technology
    Inventors: Donald J. Abraham, Mona Mahran, Ahmed Mehanna, Ramnarayan Randad
  • Patent number: 5276053
    Abstract: A novel series of polycyclic amines, derivatives, methods of making the compounds, novel intermediates, compositions containing them, and methods for using them in the treatment and prevention of cerebrovascular disorders are disclosed.
    Type: Grant
    Filed: October 6, 1992
    Date of Patent: January 4, 1994
    Assignee: Warner-Lambert Company
    Inventor: Graham Johnson
  • Patent number: 5250701
    Abstract: A family of compounds has been found to be useful for right-shifting hemoglobin towards a low oxygen affinity state. The compounds are capable of acting on hemoglobin in whole blood. In addition, the compounds can maintain the oxygen affinity in blood during storage and can restore the oxygen affinity of outdated blood.
    Type: Grant
    Filed: January 19, 1993
    Date of Patent: October 5, 1993
    Assignee: Center for Innovative Technology
    Inventors: Donald J. Abraham, Ramnarayan Randad
  • Patent number: 5248785
    Abstract: A family of compounds has been found to be useful for right-shifting hemoglobin towards a low oxygen affinity state. The compounds are capable of acting on hemoglobin in whole blood. In addition, the compounds can maintain the oxygen affinity in blood during storage and can restore the oxygen affinity of outdated blood.
    Type: Grant
    Filed: May 18, 1992
    Date of Patent: September 28, 1993
    Assignees: Virginia Commonwealth University, Center for Innovative Technology
    Inventors: Donald J. Abraham, Ramnarayan Randad
  • Patent number: 5180736
    Abstract: A novel series of polycyclic amines, derivatives, methods of making the compounds, novel intermediates, compositions containing them, and methods for using them in the treatment and prevention of cerebrovascular disorders are disclosed.
    Type: Grant
    Filed: May 17, 1991
    Date of Patent: January 19, 1993
    Assignee: Warner-Lambert Company
    Inventor: Graham Johnson
  • Patent number: 5106864
    Abstract: A novel antitumor substance BE-13793C or a pharmaceutically acceptable salt thereof, which is represented by the following formula: ##STR1## an anticancer agent comprising the novel substance or a pharmaceutically acceptable salt thereof, a method of producing the novel substance and a microorganism capable of producing the novel substance are disclosed.
    Type: Grant
    Filed: March 21, 1990
    Date of Patent: April 21, 1992
    Assignee: Banyu Pharmaceutical Co., Ltd.
    Inventors: Hiroyuki Suda, Katuhisa Kojiri, Akira Okura, Kenji Kawamura, Masanori Okanishi
  • Patent number: 5071853
    Abstract: A novel series of polycyclic amines, derivatives, methods of making the compounds, novel intermediates, compositions containing them, and methods for using them in the treatment and prevention of cerebrovascular disorders are disclosed.
    Type: Grant
    Filed: February 27, 1990
    Date of Patent: December 10, 1991
    Inventors: Christopher F. Bigge, Sheryl J. Hays, Graham Johnson, Perry M. Novak, Daniel F. Ortwine
  • Patent number: 5019130
    Abstract: The coloring of human hair and other keratinaceous substrates can be carried out efficiently using compositions containing certain N-aryl pyrroles as dye couplers or developers.
    Type: Grant
    Filed: November 3, 1989
    Date of Patent: May 28, 1991
    Assignee: Clairol Incorporated
    Inventor: Lawrence A. Flood
  • Patent number: 4772725
    Abstract: Novel anthrimidecarbazole compound of the formula ##STR1## as an olive-coloring vat dye exhibiting an increased ability to reflect infra-red light.
    Type: Grant
    Filed: December 30, 1987
    Date of Patent: September 20, 1988
    Assignee: Ciba-Geigy Corporation
    Inventor: Hans Altermatt
  • Patent number: 4670042
    Abstract: A compound of the formula: ##STR1## wherein R.sup.1 is a C.sub.1 -C.sub.5 alkyl group, a C.sub.3 -C.sub.5 alkenyl group, a C.sub.3 -C.sub.5 alkynyl group or a C.sub.1 -C.sub.3 alkoxymethyl group, X is a hydrogen atom, a fluorine atom or a chlorine atom and A is a group of the formula: ##STR2## in which R.sup.2 is a hydrogen atom or a methyl group, R.sup.3 is a hydrogen atom or a methyl group and the nitrogen atom is bonded to the benzene ring, which is useful as a herbicide.
    Type: Grant
    Filed: October 2, 1985
    Date of Patent: June 2, 1987
    Assignee: Sumitomo Chemical Company, Limited
    Inventors: Toru Haga, Eiki Nagano, Ryo Sato, Kouichi Morita
  • Patent number: 4560768
    Abstract: Polyimido-ester compounds having the formula RO--C(O)--R.sub.1 --C(O)--OR are disclosed wherein R is an alkylene N-dicarboximido radical containing cycloolefinic unsaturation and R.sub.1 is the divalent residue of an unsaturated polycarboxylic acid such as fumaric, itaconic, aconitic, mesaconic, or glutaconic acid. These compounds are blended with unsaturated resins such as unsaturated polyester resin or vinyl ester resin, and polymerizable unsaturated monomers such as styrene to provide thermosettable resin compositions which can be cured to provide castings or laminates with improved resistance to thermal aging.
    Type: Grant
    Filed: December 16, 1983
    Date of Patent: December 24, 1985
    Assignee: The Dow Chemical Company
    Inventors: Robert E. Hefner, Jr., Douglas L. Hunter
  • Patent number: 4520202
    Abstract: Process for preparing 4,4'-dibenzoylaminoanthrimidecarbazole, characterized in that 4,4'-diaminodianthrimide is benzoylated and carbazolated, both steps being carried out in one-vessel fashion and the 4,4'-diaminodianthrimide having been obtained by oxidizing a mixture of 1-aminoanthraquinone and 1,4-diaminoanthraquinone in a molar ratio of 0.9:1 to 1.4:1 in 30 to 60% strength H.sub.2 SO.sub.4 and then reducing.
    Type: Grant
    Filed: November 29, 1982
    Date of Patent: May 28, 1985
    Assignee: Bayer Aktiengesellschaft
    Inventor: Josef Stawitz
  • Patent number: 4459233
    Abstract: A process for purifying crude organic pigments, wherein the crude pigment is suspended in a mixture of two organic liquids which are partially or completely immiscible with one another, the suspension is mixed at 50.degree.-180.degree. C. until equilibrium has been reached, the phases are allowed to separate, the phase containing the impurities (i.e. the first liquid) is separated off and the purified pigment is isolated from the other phase (i.e. the second liquid).Finely divided crude pigments can, directly after purification, be converted, while in the second liquid, into pigmentary forms.The process gives pigments of high purity, which after conversion into pigmentary forms give deep, brilliant colorations.
    Type: Grant
    Filed: March 31, 1982
    Date of Patent: July 10, 1984
    Assignee: BASF Aktiengesellschaft
    Inventors: Wolfgang Fabian, Rudolf Polster
  • Patent number: 4408056
    Abstract: Nitrotrianthrimidecarbazoles of the formula ##STR1## in which the NO.sub.2 group is in the .alpha.- or .beta.-position and R.sub.1, r.sub.2 ; R.sub.3 and R.sub.4 designate hydrogen or halogen such as chlorine and bromine,their use as vat dyestuffs, a process for their preparation, and the use, as vat dyestuffs, of compounds which in the formula (I) have an NH.sub.2 group in place of the NO.sub.2 group.
    Type: Grant
    Filed: December 29, 1982
    Date of Patent: October 4, 1983
    Assignee: Bayer Aktiengesellschaft
    Inventors: Walter Hohmann, Josef Stawitz