Abstract: An injection device is disclosed which is designed to receive therein a two-compartment syringe, and to be used to mix the pharmaceutical agents and then conduct injections. The injection device comprises a cylindrical barrel portion so configured that the two-compartment syringe can be inserted therein in a rear-end first manner, a piston rod for pushing the slidable rear wall to advance, a front spring that is compressed, when the two-compartment syringe is inserted, and then push back the piston rod in the forward direction, and a sleeve which can be shifted back and forth and is provided by screw engagement with the outer surface of the rear part of the barrel portion to block the forward movement of the piston rod.

Abstract: The present invention relates to a collar for use with an inflation device, the collar having a release mechanism allowing a user to advance and/or retract a plunger in a non-threaded fashion. According to one embodiment of the present invention, the release mechanism has a first position in which the plunger is threadably engaged and a second position in which the plunger can be advanced and/or retracted in a non-threaded fashion. In one embodiment the release mechanism includes a displaceable member and an engagement mechanism. In another embodiment, the release mechanism is utilized with a sleeve which allows the collar to be decoupled from the inflation device by rotation of the collar.

Abstract: The present invention includes syringes for dispensing liquids. The devices of the invention increase ease of volume control and hence application thereof while minimizing any spillage or fluid migration up the side of the syringe tip.

Abstract: The present embodiments relate to devices and methods for injection. More specifically, the devices and methods provide an ergonomic aspect. In some embodiments, the devices and methods are especially useful in the administration of low volumes of dermal fillers to a subject.

Abstract: A device for dispensing a product in doses including a casing element, a dosing device shiftable relative to the casing element in a dispensing direction, a setting device for setting the position of the dosing device, and a restoring element for returning the dosing device to a starting position, wherein a movement of the dosing device in the dispensing direction charges the restoring element.

Abstract: The present invention relates to a contact free arrangement for determining an absolute position of a member adapted for setting an amount of medicament to be injected from a medication delivery device, or adapted for determining an amount of medicament injected from a medication delivery device. The arrangement according to the present invention comprises at least one track of reflector means, at least one emitter means, and at least one receiver means. The at least one emitter means and the at least one receiver means are adapted to electrically couple to a number of the reflector means. The electrical coupling may be capacitive or inductive. In addition, the present invention relates to a medication delivery device or a syringe having such arrangement.

Abstract: Systems and methods for storing and dispensing a fluid on-demand includes a reservoir; an energy storage device coupled to the reservoir to store energy, wherein the energy is mechanically generated by a user's action; a cannula assembly adapted to be positioned on a patient and coupled to the reservoir prior to use; and a sequencer coupled to the reservoir and the energy storage device to allow the fluid to be dispensed upon command.

Abstract: A dose setting element for an injection device, comprising a first part being adapted to rotate during setting of a dose, and a second part being adapted to engage with the first part. Each time the first part has been rotated through a first specific angle the second part is caused to rotate through a second specific angle being smaller than the first specific angle. Keeps track of the total dose set since a cartridge was inserted. When the second part has been rotated a predefined number of times is abuts a stop, thereby preventing further dose setting. Prevents setting of a dose beyond an amount remaining in the cartridge. It is not necessary that part of the limiting mechanism travels a distance corresponding to the total dose due to the two separate parts. This allows the dose setting element and injection device to be small as compared to prior art dose limiting mechanisms. Further, an injection device comprising the dose setting element. Suitable for self-injection, e.g. of insulin.

Abstract: Microspheres to be implanted into a patient are metered and mixed with fluids, cells, or tissues withdrawn from the patient's own body, and reinserted into the patient's body to achieve augmentation, repair or other treatment of the patient's tissue.

Abstract: A compact fluid dispenser for use in controllably dispensing fluid medicaments, such as, antibiotics, analgesics, and like medicinal agents from the device reservoir. The fluid dispenser includes a unique stored energy mechanism which takes the form of a constant force spring member of novel design that provides the force necessary to continuously and substantially uniformly expel fluid from the device reservoir. The device also includes novel adjustable flow rate control assembly that is disposed intermediate the fluid reservoir outlet and the outlet port of the device for precisely controlling the rate of fluid flow from the outlet port toward the patient.

Abstract: A syringe is provided for limiting the dosage of medication delivered to a patient to a pre-determined amount. The syringe assembly includes an injector assembly and vial of medication. The injector assembly has an adjustable dosage control which rides in a track on the injector assembly for limiting vial movement. Once an appropriate dosage is selected using the dosage control, the vial is engaged with the injector assembly. As the vial is pressured into the injector assembly medication is forced through the needle. Once the vial reaches the dosage control, vial movement is obstructed and dosage effectively limited.

Abstract: A self-contained system for medication injection is activated by the user, who is able to distribute the medication through the self-contained needle system for intradermal or intramuscular application of the medication. The self-contained system may be a medication delivery pen having a pen body assembly comprising a distal end, a proximal end and a needle array containing a plurality of needles disposed within the pen body assembly.

Abstract: A drug delivery device capable of working in at least two different modes which includes a dose injection mode and a set-up mode. The drug delivery device automatically changes from the dose injection mode to the set-up mode and vice versa in accordance with the detection of the cover by a cover detection switch. In the dose injection mode doses can be set and injected; in the set-up mode various parameters assisting the use of the drug delivery device can be set. This setting is preferably done by selecting the parameters from a menu, also in this mode historical data stored in the device can be viewed.

Abstract: A transdermal delivery device includes a plurality of microneedles for injecting a substance such as a pharmaceutical agent into or below the stratum corneum of the skin. The device has housing formed from a top and bottom wall to define a chamber for containing a pharmaceutical agent. An inlet port is provided in the top wall of the housing for supplying the pharmaceutical agent to the chamber and directing the agent to the microneedles. The housing can have a Luer lock type fitting for coupling with a syringe having a Luer lock collar to inject the pharmaceutical agent into the housing. The housing can be divided into a plurality of chambers by an internal wall for supplying different agents simultaneously or sequentially to a patient. The microneedles have a length of about 5-250 microns and generally about 50-100 microns.

Abstract: Low-dosage syringes for use in administering small dosages of medicine are disclosed. An illustrative low-dosage syringe can include an elongate syringe barrel having an interior chamber adapted to receive a supply of fluid, a plunger member slidably disposed within the interior chamber, and a tip member defining an inner lumen in fluid communication with the interior chamber. The configuration of the syringe barrel, including the wall thickness of the barrel relative to the outer diameter and to the length of the barrel, may permit small dosages of medicine to be accurately administered while also allowing the user to easily manipulate the syringe barrel with their fingers.

Abstract: A setting mechanism for setting or selecting a quantity of a substance to be dispensed from an injection device, the mechanism including a dose setting element and an adjusting element which can be operated by a user, wherein the adjusting element is operably coupled to the dose setting element and an overstrain lock is provided between the dose setting element and the adjusting element.

Abstract: An injection device for administering a liquid product, the device including a drive mechanism, an engaging member and a catch including a number of latching elements, wherein at least one of the engaging member and the number of latching elements is relatively moveable to the other to generate a haptic and/or acoustic signal comprising a number of discrete signals during a relative movement, wherein one of the catch and the engaging member is coupled to the drive mechanism and the drive mechanism generates a variable drive speed during the relative movement, and wherein the latching elements are a distance (x0; x0??x) from each other such that a time interval between each of the number of discrete signals is constant. A method for generating a haptic and/or acoustic signal in use of an injection device is encompassed.

Abstract: The device comprises a first holding device (10) which is attached to a syringe barrel (11) of a syringe, and a second holding device (25) which is attached to a plunger barrel (21) of the syringe. Both holding devices are linearly guided relative to each other. One of the holding devices carries a dial gage (31) comprising a rotary shaft (30). Said rotary shaft (30) is in engagement with a toothing (29) of the other holding device. An indicator (32) indicates, with a high resolution, the movement of the plunger rod relative to the syringe barrel such that a highly accurate fine dosing of a liquid discharged from the syringe can be realized.

Abstract: A medication dispensing apparatus that provides a mechanical advantage. During dose preparing, a nut rotating element (410) and a screw element (368) are in a first axial arrangement such that a screwing motion of the nut rotating element and screw element relative to the apparatus housing that moves the elements a first axial distance from a home position screws a nut (364) along a drive member threaded shaft (362) a second axial distance different than the first axial distance. During dose dispensing, the nut rotating element and the screw element are in a second axial arrangement, whereby a screwing motion of the screw element relative to the housing back toward the home position advances a plunger (366) in the distal direction to axially advance the nut and thereby the drive number and a fluid container piston to dispense medicine.

Abstract: An administering apparatus for delivering a dosage of product including a casing with a reservoir for the product, a piston within the reservoir to deliver the product, a piston rod for engaging the piston, a drive device for driving the piston rod, and a dosage setting member mechanically engaging the piston rod and a stopper for the dosage setting member. The casing includes a front casing section containing a reservoir for the product and a rear casing section detachably connected to the front casing section. The front casing section is connected to or forms a first latching element, and the rear casing section is connected to or forms a second latching element. The latching elements are in latching engagement when the casing sections are connected. The casing sections may be axially fixed to one another by the latching engagement.

Abstract: A medication delivery device comprises an injection device having a reservoir comprising a medicament to be ejected, and a sensor arranged to detect an ejection of the medicament from the injection device, the sensor being arranged to output a signal comprising ejecting information, and a processor for collecting and storing the ejection information.

Abstract: A device for delivery of medicament includes a main housing, a container having at least two compartments, each containing a component of the medicament to be injected, and arranged to be connected to a patient delivery element, a longitudinally movable piston and a spring arrangement acting on the piston to exert a force on the components, a first holding element for holding the piston in a force-loaded state, and at least one activator for releasing the piston, a second holding element for stopping the piston when it has moved a certain first distance after one activation of the at least one activator and holding the piston in that position, wherein the force from the piston/spring arrangement and the movement causes the compartments to communicate with each other and the components to mix.

Abstract: A threaded rod for an injection device, wherein the rod includes a thread on an external surface, the thread supporting or carrying, at least partially, engaging elements and/or teeth. In one embodiment, the present invention encompasses a dosing mechanism for an injection device, including a rotational defining element which enables a threaded rod to be rotated in one direction, rotation being blocked or prevented in the counter direction by at least one blocking element which co-operates with a thread of the threaded rod, wherein the thread carries, supports or has associated teeth and/or engaging elements. In one embodiment, the present invention encompasses an injection device including at least one engaging element which co-operates with a blocking element associated with a threaded rod, whereby the threaded rod is rotatable in one direction in relation to the injection device, rotation in the opposite direction being prevented.

Abstract: Injector device, and method for its operation, for containers of syringe type, comprising a barrel of axially roughly constant cross-section, a front opening and at least one movable wall inserted in the barrel for displacement of a container content, the injector comprising a) a housing or housing part arranged to receive the container at least axially stationary, b) an integral or composite piston rod arrangement operable to displace the container movable wall at least in the forward direction and c) a track system for controlling or sequencing the piston rod movements, the track system comprising at least one cooperating track and follower, the cooperating track and follower being arranged stationary with respect to the housing and the piston rod respectively, or vice versa, and in cooperation allowing at least one forward for the piston rod. The track system comprises arrangements initiation, dose setting and expulsion of container content.

Abstract: The present invention is a fluid dispensing device particularly suited to medicine but also having many other applications. The user manually and selectively dispenses any of one or more fluids, typically a drug, contained within the device. Generally, the device comprises a frame that holds multiple hypodermic syringes and channels the dispensed fluids through a manifold. A flushing solution, for example a saline solution, enters the manifold, flows past each of the points where the syringes input into the manifold and continues to flow out of the device to a patient where the flushing solution and dispensed fluid are delivered to a patient.

Abstract: A medication delivery system, comprising: a movable part (230, 232) adapted to move relative to a stationary part; at least two conductors (234, 236) which are arranged such that an electrical characteristic is defined by the mutual position of the movable and the stationary part and/or by movement of one of said parts relative to the other; and a detector for detecting a change of said electrical characteristic, wherein the parts are stationary relative to each other during dose setting and in that the parts are moved relative to each other during dose ejection, such that that detector provides a signal indicative of the actual amount of the ejected dose.

Abstract: An injection including a syringe having a barrel for containing a medicament, a shell for receiving the barrel with a needle projecting therefrom, a drive mechanism for moving a plunger disposed within the barrel, and a manually operative mechanism for moving the plunger in a stepwise manner to eject doses of the medicament from the barrel through the needle.

Abstract: The present invention relates to a medicament delivery device such as an injector for self-administration of a medicament. Those using such devices are often infirm or have impaired vision. There is accordingly a dead for a medicament delivery device in which an amount of a dosage of medicament to be delivered can be selected relatively quickly by the firm and infirm alike and in which the amount of the dosage may readily be controlled and determined. Also there is a need to display the amount of the dialed dosage of medicament on the rotatable knob in figures sufficiently large and clear to be legible by those having a degree of impaired vision.

Abstract: An inhalation device for delivering doses of medicament to a user comprising:—a canister (5), said canister being adapted to accommodate the medicament to be dispensed to a user, and—a counter (15) which is connected to the canister (5). According to the invention—the canister (5) is adapted to receive the counter (15) on a base end (6a),—the counter and/or the canister further having contact parts (18, 20) for their attachment having means for increasing the friction and thereby allowing the counter to fixedly be attached onto the canister in a range of different positions in the lengthwise direction,—the counter further being adapted to during the process to assemble the counter to the canister, be urged onto the canister until the length of the counter and canister together is within a predefined tolerance of a predefined length.

Abstract: A delivery device includes a durable housing portion and a separable disposable portion that selectively engage and disengage from each other. The disposable housing portion secures to the patient-user and may be disposed of after it has been in use for a prescribed period. Components that normally come into contact with a patient-user or with infusion medium are supported by the disposable housing portion, while the durable housing portion supports other components such as electronics and a drive device. A reservoir is supported by the disposable housing portion and has a moveable plunger that operatively couples to the drive device, when the disposable and durable housing portions are engaged.

Abstract: An administering apparatus with a dosage display, including a casing, a reservoir for a fluid product, a driven device which acts on the product, a dosing means for selecting a product dosage to be delivered which includes a dosage scale including a number of dosage marks axially spaced from each other, and a drive device coupled to the driven device for driving the driven device, the drive device performing a delivery stroke from an initial position, in a drive direction, to a delivery stopper, the length of the delivery stroke counter to the drive direction being limited by selecting the product dosage using the dosing means, wherein the casing is transparent at least in an area overlapping the dosage scale, and wherein the drive device forms an indicator to the dosage scale in order to indicate the initial position of the drive device.

Abstract: An administering apparatus for delivering a dosage of product including a casing with a reservoir for the product, a conveying device, a dosage setting member mechanically coupled to the conveying device and a stopper for the dosage setting member. The conveying device is formed by a driven device and a drive device. The driven device, a piston rod in one embodiment, is mounted by the casing such that it performs a delivery movement in the form of a delivery stroke in an advancing direction along a translational axis to deliver a product dosage selected using the dosage setting member. The delivery movement of the driven device is effected with the drive device, the drive device and the driven device being coupled.

Abstract: A process and a device for dosing a pharmaceutical agent, preferably a liquid, are proposed. To achieve an enhanced dosing accuracy, a first component that is produced in batches, such as a shaped seal, is combined with a second component, such as a guide pipe selected from a suitable group guide pipes, wherein the suitable group of second components is selected based on at least one decisively significant value of the respective batch first components and is distinguished by an essential value of the second component which will optimize the sealing between the first and second components.

Abstract: A medication dispensing apparatus that provides a mechanical advantage. During dose preparing, a nut rotating element (410) and a screw element (368) are in a first axial arrangement such that a screwing motion of the nut rotating element and screw element relative to the apparatus housing that moves the elements a first axial distance from a home position screws a nut (364) along a drive member threaded shaft (362) a second axial distance different than the first axial distance. During dose dispensing, the nut rotating element and the screw element are in a second axial arrangement, whereby a screwing motion of the screw element relative to the housing back toward the home position advances a plunger (366) in the distal direction to axially advance the nut and thereby the drive member and a fluid container piston to dispense medicine.

Abstract: A syringe-like device having a chamber in which a pressurizing piston reciprocates. The chamber is connected on one end to a vial containing a drug to be delivered to an eye and on the other end to a needle or cannula for administering the drug to an eye. Pulling proximally backwards on the piston creates a vacuum in the chamber and draws the drug out of the vial. Upon release of the piston, a spring pushes the piston forward, pressurizing the chamber. Delivery of the drug is controlled by a roller pinching off a section of compliant tubing between the chamber and the cannula, with a design similar to a peristaltic pump. A one-way valve prevents the drug from being expelled back into the vial. The flow rate of the drug out of the cannula can be controlled by rotation of the roller.

Abstract: A fluid dispenser for use in controllably dispensing fluid medicaments, such as antibiotics, oncolytics, hormones, steroids, blood clotting agents, analgesics, bio pharmaceuticals and like medicinal agents from a reservoir that has been filled from prefilled containers. The fluid dispenser includes a housing to which fill vials can be connected for filling the dispenser reservoir with the fluid, and a stored energy source provided in the form of a substantially constant-force spring that provides the force necessary to continuously and uniformly expel fluid from the device reservoir. The fluid dispenser also includes a fluid flow control assembly that precisely controls the flow of the medicament solution to the patient.

Abstract: A compact fluid dispenser for use in controllably dispensing fluid medicaments, such as, antibiotics, oncolytics, hormones, steroids, blood clotting agents, analgesics, and like medicinal agents from prefilled containers at a uniform rate. The dispenser uniquely includes a stored energy source that is provided in the form of a substantially constant-force, compressible-expandable wave spring that provides the force necessary to continuously and uniformly expel fluid from the device reservoir. The device further includes a fluid flow control assembly that precisely controls the flow of medicament solution to the patient.

Abstract: A device for displaying a dosage setting on an injection device includes a reading area in a casing of the injection device and a scale band arranged in the interior of the casing. The scale band is at least partially guided past the reading area by a guiding device, and can be set in accordance with a dosage setting of the injection device, and the dosage setting can be read from the reading area. A transport device, coupled to a dosage setting device of the injection device, is provided for transporting said scale band past the reading area.

Abstract: A medication injector apparatus such as an injection pen. The injection pen includes a resettable, cartridge plunger drive assembly including an axially floating nut, a cartridge plunger engaging screw, and a drive clutch movable with the nut and which when rotated causes the screw to screw through the nut. When a cartridge assembly is mounted to the pen base, the floating nut and drive clutch are shifted proximally such that the drive clutch is in torque transmitting engagement with a rotatable drive member of the pen, such that rotation of that drive member results in drive screw advancement through the nut in the distal direction. When the cartridge assembly is not mounted to the pen base, the floating nut and drive clutch are biased distally to disengage the drive clutch from torque transmitting engagement with the rotatable drive member and to thereby allow the drive screw to be reset proximally through the nut to a position more retracted within the pen base.

Abstract: The present invention is an injection device for injecting a fluid product from a reservoir includes a casing having at least two casing portions. The device also includes a mounting for the reservoir such as an ampoule containing the fluid product to be administered, wherein one casing portion at least partially surrounds the reservoir. An activating element for triggering fluid product administering is provided. The at least one casing portion surrounding the reservoir is movable relative to the other casing portion or parts, such that by moving the movable casing portion, the reservoir and/or an injection needle connected to the same is accessible from the outer side of the casing, in order to be replaced.

Abstract: A frontloaded injection device that includes a cartridge holder into which a replaceable cartridge containing a fluid is inserted. The cartridge holder includes a closing element such as a pair of claws which are displaceable in a radial direction. The closing element is provided at the front of the injection device and locks the cartridge by gripping at the neck part of the cartridge after the cartridge has been loaded into the cartridge holder from the front of the injection device. The closing element is preferably biased in an outwardly radial direction when the locking element is moved axially out of the cartridge holder.

Abstract: A device for administering an injectable product in doses including a casing, a reservoir for the product, a piston which displaces product towards a reservoir outlet and out of the reservoir when it slides in an advancing direction, a drive member which may be slid along a sliding axis, thereby pushing the piston in the advancing direction, and a dosing member which is mounted in the casing and may be slid, preferably rotatably, about the sliding axis of the drive member for setting a product dose, wherein a bearing surface between the dosing member and the casing is lubricated and at least one lubricating agent reservoir is provided on the bearing surface.

Abstract: A device and method for neural transplantation in the human brain comprising a microinjector (1), transplantation cannula (2) and bullet guide (16) is disclosed. The microinjector (1) is designed to connect to the proximal end of a syringe barrel (7) and plunger (12) while the transplantation cannula (2) interfaces with the distal end of the syringe barrel (7). In combination, the microinjector (1) and transplantation cannula (2) permit the delivery of multiple cell grafts in a three-dimensional array using a unique spiral technique. The bullet guide (16), which is attachable to a commercially available stereotactic frame, is a multiple channel adapter that functions as a mechanical guiding system for the transplantation cannula (2) and permits plural, spaced deployment of the cannula (2) without adjusting or disturbing the frame.

Abstract: An end-of-content arrangement for preventing a dose setting member of an injection device to be set to a dose larger that the medicament remaining in the injection device. The arrangement is particular suitable for injection devices operating with non-equistant dose volumes. The arrangement comprises an indentation provided on the housing or on the dose setting and injection member which indentation arrest a stop member when less than one dose unit is left in the cartridge. The stop member is coupled to the dose setting member such that the interaction between the indentation and the stop member prevents a dose larger that the remaining medication in being set.

Abstract: A drive mechanism suitable for use in drug delivery devices is disclosed. The drive mechanism may be used with injector-type drug delivery devices, such as those permitting a user to set the delivery dose. The drive mechanism may include a housing, a dose dial sleeve having a helical thread of a first lead, and a two-part piston rod. The two-part piston rod may include an outer part having a helical thread of a second lead and an inner part having a helical thread of a third lead. In such an embodiment, the first lead of the thread of the dose dial sleeve may be equal to the sum of the second lead of the thread of the outer part of the piston rod and the third lead of the thread of the inner part of the piston rod.

Abstract: A dose dial and drive mechanism for use in a drug delivery device having a housing, a dose dial sleeve, a piston rod, a drive sleeve threadedly connected to the piston rod, a reset sleeve, which is located between the drive sleeve and the housing, and a dose display. When the dose dial sleeve travels towards the second end of the housing the reset sleeve is carried with the dose dial sleeve towards the second end of the housing resetting the dose display to a zero position and when the dose dial sleeve and/or the reset sleeve travels towards the first end of the housing, the dose dial sleeve and/or reset sleeve engage(s) with the drive sleeve thus advancing both the drive sleeve and the piston rod towards the first end of the housing.

Abstract: A device for withdrawing blood for diagnostic purposes including a lancet and a lancet drive having a loadable elastic drive spring provided within an elongated housing. A relaxing motion of the drive spring is converted into a puncturing motion to move the lancet at high speed in a puncturing direction until its tip exits out of an opening of the housing. The device includes a transmission in the housing that has an input side that transforms the motion of a loading element along a linear loading path into a rotational motion of a lancet drive rotor to load the lancet drive rotor by tensioning the drive spring. When the lancet drive is triggered, the output side of the transmission converts a rotational motion of the lancet drive rotor, driven by the drive spring, into the puncturing motion in a direction along the main axis.

Abstract: The invention concerns a syringe for administering medication to an animal. The syringe includes a handle that may be manually actuated to dispense medication to the animal. The syringe also includes a valve that controls the flow of medication both into and out of the syringe. A sensor device on the syringe monitors when the medication has been administered in order to inform any attached pump that the syringe may be refilled. An LED informs the user when the syringe has been filled with medication and is ready for the administration of medication to the animal.

Abstract: An infusion system for infusing a liquid into a body includes an external infusion device and a remote commander. The external infusion device includes a housing, a receiver, a processor and an indication device. The receiver is coupled to the housing and for receiving remotely generated commands. The processor is coupled to the housing and the receiver to receive remotely generated commands and to control the external infusion device in accordance with the commands. The indication device indicates when a command has been received and indicates when the command is being utilized to control the external infusion device so that the external infusion device is capable of being concealed from view when being remotely commanded. The remote commander includes a commander housing, a keypad for transmitting commands, and a transmitter for transmitting commands to the receiver of the external infusion device.

Abstract: A medication delivery pen is provided including a leadscrew having a plurality of threads; a driver coaxially disposed about at least a portion of the leadscrew; a dosing ring non-rotatably disposed on the driver, the dosing ring also being slidable along the driver; and, a dose knob coaxially disposed about the dosing ring. At least one tooth is formed on one of the dose knob and the dosing ring, and at least one groove is formed on the other of the dose knob and the dosing ring, with the groove being formed to receive the tooth. The dosing ring is selectively movable relative to the dose knob from a first position where the tooth and the groove are spaced apart to a second position where the tooth is received within the groove, the dosing ring being rotatable with the dose knob with the dosing ring being in the second position.