Abstract: A dose setting mechanism for a drug delivery device is disclosed. The mechanism comprises an outer housing and an inner housing having an external groove and a helical spline. The inner housing helical spline guides a driver to dispense a set dose. A dial sleeve is disposed between the outer and inner housing and is rotatably engaged with the inner housing. When a dose is set, the dial sleeve is rotated and translates away from both the outer housing and the inner housing.

Abstract: A driver for driving a spindle of a drug delivery device is provided. Said driver comprises a first component and a second component rotationally coupled to said first component. During resetting of said drug delivery device, said first component is rotationally decoupled from said second component.

Abstract: A method and system for priming a drug delivery device are provided. The drug delivery device includes a dose dial sleeve and an internal housing portion. The dose dial sleeve is coupled to the internal housing. The dose dial sleeve rotates on a substantially circumferential rotational path during priming of the drug delivery device. Further, the dose dial sleeve rotates on a helical path during dose setting of the drug delivery device.

Abstract: A drug delivery device is provided comprising a dose setting mechanism having a spindle and a cartridge holder coupled to the dose setting mechanism. The cartridge holder comprising a cartridge having a movable bung at one end of the cartridge. The cartridge holder must be rotated before a dose may set with the dose setting mechanism.

Abstract: The present invention relates to a drug delivery device (6) comprising a dose button (1). Furthermore it relates to a method for manufacturing a dose button (1) by using a cutting-off process. The aim of the present invention is to minimize the risk of using a drug delivery device (6) containing a wrong drug. By means of tactile features, a drug delivery device (6) is distinguishable from another drug delivery device (6) containing another type of drug. This tactile feature is manufactured by using a dose button (1) out of metal which is milled or lathed.

Abstract: A maximum settable dose feature is disclosed that is set by a user or health care professional one time that prevents future injections from exceeding the desired maximum dose. The feature includes a locking band (5) initially in an unlocked configuration, which transforms to a locked configuration when activated after setting a desired maximum dose. The feature can include a trigger mechanism (6,11) to transform the locking band (5) to the locked configuration.

Abstract: A hand-held injection device (2) for injection of a medicament from a first medicament cartridge (40), injection device comprising: a housing (4) being designed to be held in one hand of a user, the longitudinal direction of the housing (4) running between the thumb and the other fingers of the hand of the user, a drive mechanism (42) for selectively dispensing the medicament from the first medicament cartridge (40), a dial dose mechanism (12, 14), a control panel region (8) with at least two operation buttons (12, 14, 16) disposed therein for activating operation functions of the injection device (2), an electronic control unit for controlling the operation of the drive mechanism 42 in response to the dial dose mechanism (12,14) and a display panel (10), in which the required dosage to be dispensed is presented to the user on the display panel (10), wherein between two of the operation buttons (12, 14, 16) a recess is provided in the control panel region (8) and in that in the recess (R) a discrete butto

Abstract: The invention relates to a dose setting mechanism, which is operable to be coupled to a medication cartridge and which comprises means that prevent the user from setting a dose greater than the remaining medication in the cartridge. The dose setting mechanism comprises a shaft. A helical groove having a first pitch is provided along a first portion of the shaft. The dose setting mechanism further comprises a nut member disposed on the helical groove of said shaft. During dose setting, the shaft is rotated relative to the nut member while the nut member traverses along the groove from a distal end of the shaft towards a proximal end of the shaft.

Abstract: A dose setting mechanism for a drug delivery device is disclosed. The mechanism comprises an outer housing and an inner housing having an external groove and a helical spline. The inner housing helical spline guides a driver to dispense a set dose. A dial sleeve is disposed between the outer and inner housing and is rotatably engaged with the inner housing. When a dose is set, the dial sleeve is rotated and translates away from both the outer housing and the inner housing.

Abstract: A dose setting mechanism of a drug delivery device and a respective method of assembling said dose setting mechanism. The dose setting mechanism includes an inner housing having a helical groove along an external surface of the housing. The inner housing includes a rotational stop member near one end of the helical groove. The dose setting mechanism also includes a dial sleeve rotatably engaged with the helical groove of the inner housing. When a user rotates the dial sleeve to select a dose, the rotational stop member prevents the user from selecting a dose greater than a pre-defined maximum selectable dose.

Abstract: A resettable dosing mechanism comprises a dose button and a dial grip operatively coupled to the dose button. A spindle acts on a bung of a cartridge and a driver is operatively coupled between the dose button and the spindle. During an injection of the dose, the dose button moves in an axial direction to cause the spindle to administer the dose. During resetting of the dose setting mechanism, the spindle is retracted back into the dose setting mechanism. An advantageous resetting mechanism is described.

Abstract: A method and system for priming a drug delivery device are provided. The drug delivery device includes a forced priming feature that requires the user to move the dose dial sleeve (3) axially to cause the spindle (5) to pre-load a cartridge bung before a first dose can be dialed.

Abstract: A method and system for proving a drug delivery device having a variable maximum dose. The drug delivery device comprising a first tubular member and a second tubular member rotatably coupled to the first tubular member. A maximum stop component is operatively coupled to the first tubular member and the second tubular member such that the maximum stop component is movable from a first position to a second position. The first position defines a first maximum dose that may be set by a user of said drug delivery device and the second position defines a second maximum dose that may be set by the user of said drug delivery device.

Abstract: An injection device for injection of set doses of medicine from a cartridge, in which syringe a dose is set by screwing a nut up along a threaded piston rod, whereby a dose setting drum, which carries on its cylindrical surface along a helix a scale of which a number corresponding to the set dose is shown in a window in the housing of the syringe, and an injection button, which is elevated over the end of the syringe, are moved axially a distance which is larger than the axial movement of the nut. A gear wheel transmission is established between the nut and the injection button.

Abstract: A valve is provided for controlling flow along a fluid line that includes an outer shell and an inner housing slidably disposed therein that includes connector threads surrounding a boss on one end and a passage through the boss. A backing member is coupled to the outer shell and has a sealing pin extending into the passage. A connector may be threaded into the one end of the inner housing, thereby slidably engaging the connector threads, causing the inner housing to move helically from a closed position wherein the sealing pin engages an outlet opening at the distal end of the boss to seal the outlet opening and an open position wherein the inner housing is directed away from the sealing pin to open a fluid path through the valve, around the pin, and through the outlet opening.

Abstract: A dose setting mechanism for a drug delivery device is disclosed. The mechanism comprises an outer housing and an inner housing having an external groove. The inner housing guides a driver to dispense a set dose. A dial sleeve is disposed between the outer and inner housing and is rotatably engaged with the inner housing. When a dose is set, the dial sleeve is rotated and translates away from both the outer housing and the inner housing.

Abstract: The invention refers to a method and an element for biasing a cartridge in a drug delivery device. The element for biasing the cartridge in a cartridge housing of a drug delivery device and an according system comprising the element and the drug delivery device are provided which is a self retained element comprising a first member having a shape that allows passage of a spindle of the drug delivery device. The self retained element biases the cartridge against an inner surface of the cartridge housing. This cartridge could be a removable cartridge.

Abstract: A dose setting mechanism for a drug delivery device is disclosed. The mechanism comprises an outer housing (17) and an inner housing (5) having an external groove (30; 31). The inner housing guides a driver (7, 9) having either a blocking or locking member (11; 11?) disposed inside the driver that can lock a flexible tab (21) to an internal groove during dose delivery in the inner housing such that the driver follows the path of the groove and to advance a spindle to move a cartridge bung. A dial sleeve (3) is disposed between the outer and inner housing and is rotatably engaged with the inner housing.

Abstract: A medication dispensing device with a housing and a member wherein the member is moveable in a distal direction is useful in delivering medication to a patient. A fluid container can be used with the device and often has a moveable piston at one end and an outlet at the other. The member receives a force from a user and drives the piston in the distal direction to expel medication. A intermediate system is disposed between the member and the piston including a gear set that has a pinion in meshed engagement with a rack. The system allows the member to move a greater distance than the piston moves thereby increasing the force on the piston.

Abstract: A dose display mechanism for a drug delivery device is disclosed. The display mechanism has an elongated dose setting dial with both an external helical thread and external linear grooves extending from one end to the other end. A counter ring is mounted surrounding the setting dial. The counter ring has ribs on its inner surface which engage the grooves and permit the counter ring to move axially along the setting dial but prevent it from rotating relative to the setting dial. Indicia, in the form of digits, are arranged helically on the outer surface of the dose setting dial. The digits are spaced at a pitch which corresponds to the pitch of the external helical threads.

Abstract: An assembly for a drug delivery device is provided comprising a housing having a distal end and a proximal end, a dose button configured to be moved with respect to the housing for setting and delivering a dose of a drug from the device, and a blocking member. The blocking member is adapted and arranged to be releasably coupled to the housing such that, when the blocking member is coupled to the housing, movement of the dose button with respect to the housing is prevented. Furthermore, a drug delivery device is provided.

Abstract: Ampoules for dispensing flowable substances and metering systems incorporating the same are described herein. An ampoule for a flowable substance includes an ampoule body comprising an interior space for receiving the flowable substance and an inner circumferential surface having a guide region and a sealing region. A piston may be disposed in the interior space of the ampoule body such that the piston is slidably displaceable along a direction of displacement. The piston includes a one sealing element for forming a seal with the inner circumferential surface in a contact zone on the outer circumference of the sealing element. The sealing element has as first compression state when the contact zone is in the guide region and a second compression state when the contact zone is in the sealing region. A second blocking device prevents movement of the contact zone from the sealing region to the guide region.

Abstract: An injection device for injection of set doses of medicine from a cartridge has a nut that is screwed up along a threaded piston rod during a dose setting operation. The nut is screwed along the piston rod by rotating a dose setting member. A rotational coupling mechanism includes an axially displaceable coupling member which is rotated as a function of axial displacement. During dose setting, the nut is allowed to rotate relative to the coupling member. During injection, the coupling member is rotationally locked to the nut. This provides a dose setting and injection mechanism wherein the nut member is both rotated during dose setting and during injection.

Abstract: The present invention relates to an injection device comprising an optically-based sensor for determining the position or setting of a dose setting member arranged to set a dose to be injected from the injection device. In particular, the present invention relates to an injection device comprising a rotatably mounted member having a plurality of optically coded paths arranged on an outer surface thereof. The rotatably mounted member is operatively connected to the dose setting member and is adapted to rotate with the dose setting member.

Abstract: An assembly for a drug delivery device (1) is proposed, comprising a housing (13) having a proximal end and a distal end, a dose member (23) which is displaceable in the proximal direction with respect to the housing for setting of a dose of a drug, a clutch member (28) which is displaced in the proximal direction with respect to the housing when setting the dose, and a stop member (30) configured to define a clutch stop position for the proximal displacement of the clutch member with respect to the housing, with the clutch member, when in the clutch stop position, being prevented from further displacement in the proximal direction with respect to the housing, wherein the clutch member and the dose member are configured to mechanically cooperate with one another when the clutch member is in the clutch stop position, thereby preventing further displacement of the dose member in the proximal direction with respect to the housing during setting of the dose. Furthermore, a drug delivery device (1) is proposed.

Abstract: The present invention relates to a medication delivery device, to dosing mechanisms suitable for use in medication delivery devices, in particular in pen-type injectors, preferably having dose setting means and a drive device enabling the administration of a medicinal product from a single- or multi-dose medication cartridge, to a use of such device, and to a method of manufacturing or assembling such device.

Abstract: In one embodiment, a volumetric pump in a medical fluid delivery system comprises at least one piston in a hollow cylinder, the pump having at least one inlet port through which a medical fluid can be sucked into a pump chamber during an instroke of said piston, and at least one outlet port through which the medical fluid can be expelled during an outstroke of the piston. The piston or the hollow cylinder can be actuated directly or indirectly by a rotor. This rotor transmits on the one hand a bi-directional linear movement to the piston or to the cylinder and on the other hand, a bi-directional angular movement either to the piston or to another ratable element in order to open and close alternately the inlet and outlet ports.

Abstract: A pump drive and a method thereof to dispense a liquid drug from a container having a plunger piston are disclosed. The pump drive provides a unidirectional clutch provided about a rotational axis which supports centrally a wheel. The clutch has an inner race operably connected to the plunger piston, wherein the clutch is configured to rotate both the inner race about the axis in unison with rotation of the wheel in only a first direction to advance the plunger piston, and to let the wheel rotate relative to the inner race about the axis in a second direction opposite to the first direction without advancing the piston plunger. The drive in one embodiment includes at least one shape memory alloy wire which when excited rotates the wheel in the first rotational direction to advance the piston plunger and dispense the liquid drug from the container.

Abstract: The invention relates to a dose setting mechanism (1) for a drug delivery device (2), comprising a number of separate dose setting elements (3.1 to 3.n), wherein a dose volume and/or a dose number are/is set by moving at least one of the respective dose setting elements (3.1 to 3.n) from a stack position (I) to an initial position (II), and wherein a medicament dose volume is applied by moving at least one dose setting element (3.1 to 3.n) from the initial position (II) to a dispense position (III) and wherein the movement of the dose setting element (3.1 to 3.n) from the initial position (II) to the dispense position (III) is limited by at least a height (h) of the dose setting elements (3.1 to 3.n) in the initial position (II), wherein each dose setting element (3.1 to 3.n) comprises a plurality of bulges (B1 to Bm) on at least one surface side (S1), wherein the height (h) of each dose setting element (3.1 to 3.n) equals a sum of the thickness (D) of the dose setting element (3.1 to 3.

Abstract: The present invention relates to a dial-down mechanism for an injection device comprising a torsion spring for assisting injection of a dose of medicament from the injection device, the dial-down mechanism comprising a ratchet arm (21) engaging a ring element (10) and a reset element (30) which acts on a knob located on the periphery of the ratchet arm (21) to move the ratchet arm (21) out of engagement with the ring element (10) in order to allow the set dose to be reduced.

Abstract: A drug delivery device comprises an outer housing rollable around a rotation axis and at least one stop member. The stop member protrudes radially from the outer housing of the drug delivery device and is configured to prevent rolling movement of the drug delivery device along a predetermined surface. The outer housing comprises a main housing and a dose member. The dose member is movable with respect to the main housing when setting and/or delivering a dose of a drug. The stop member comprises a first part and a second part, wherein the first part is arranged on the main housing and the second part is arranged on the dose member.

Abstract: A spring element for a drug delivery device is proposed, the spring element comprising multiple windings with two windings being mechanically coupled to each other by a rigid transverse connection. Furthermore, a drug delivery device comprising such a spring element and using such a spring element in a drug delivery device are proposed.

Abstract: The present invention relates to a handheld mechanical injection device by which set doses of a liquid medicament can be injected from a medical reservoir. The medicament is expelled through an injection needle by release of a power reservoir in the device, the power reservoir being fully or partially released by actuation of a user operable release member being positioned at or near an upper end of the injection device, the upper end being that end of the injection device which is opposite the injection needle.

Abstract: The medication delivery device is designed to receive a replaceable medication container and to determine an adjusted medication dose AD before each delivery of the medication contained in the medication container if the current content of the medication container is not a multiple of a prescribed dose D and is greater than the prescribed dose D. The adjusted medication dose AD is the dose to be delivered instead of the prescribed dose D during said medication delivery. The adjusted medication dose AD is determined by selecting one of a first dose, to that is higher than the prescribed dose D, and of a second dose, that is lower than the prescribed dose D, as a function of a variable B that cumulates the values (AD?D).

Abstract: A tracking code is adhered to a syringe label cradle for tracking each activity regarding the syringe label cradle, e.g., drug preparation, drug inventory, drug dispensing, drug administration, drug return, drug charges, etc. The tracking code may be in the form of bar or other machine readable code, as well as human readable indicia. The unique tracking code enables tracking of events pertaining to a specific syringe from the time of being prepared with a prescribed drug to its disposal or return to a hospital pharmacy. A log is created relating the patient to the specific drug used and all information inputted with respect to the tracking code.

Abstract: An injection control device having a metered/controlled injection rate proportional to the rate of withdrawal/injection, suitable for cosmetic as well as other applications is described. For example, after the cannula is advanced into an object, the cannula is withdrawn to create a tract or tunnel within the targeted area. As the cannula is withdrawn, filler material in the injection control device is uniformly deposited into the tract or tunnel via the automatic metering system. The automatic metering system incorporates a syringe activating mechanism coupled to a system which is capable of proportioning the deposition rate to the retraction/injection rate of the cannula. Accordingly, more consistent and uniform distribution of the material injected can be achieved with less cannula passes as well as requiring less dependence on the skills of the practitioner of this device.

Abstract: An injection device (1) for administering a fixed dose of a medication is provided. The injection device (1) comprises a housing (2) wherein a drive mechanism comprising a drive member (3) is at least partially enclosed and a dosing element (34) which is fixed relative to the drive member (3). Here, a dose can be set by rotating the dosing element (34) relative to the housing (2) in a dose setting direction (s) and the dose can be dispensed by pushing the dosing element (34) towards the housing (2). Moreover, a method is provided for operating an injection device (1) for the administration of a fixed dose of a medication: A dose can be set by rotating a dosing element (34), a dose can be dispensed by pushing the dosing element (34) towards the housing (2) and a dose can be cancelled by rotating the dosing element (34) in a direction opposite to the dose setting direction (s).

Abstract: A hand-held remote for a medical fluid injector includes a syringe and a conduit which may be coupled to a pressure transducer on a control circuit of the injector. Movement of a plunger within a syringe body on the syringe creates a pressure which is sensed by the pressure transducer and the control circuit responds to the sensed pressure by causing fluid to be ejected from, or drawn into, a syringe mounted to the injector. The pressure developed by the remote provides tactile feedback to an operator for improved control over injections.

Abstract: The invention refers to an interlock mechanism for restricting a rotational movement of a rotatable component (1) of a drug delivery device (10) and to a method for controlling the rotational movement of the rotatable component (1).

Abstract: To provide a syringe barrel and a syringe capable of allowing an operator to feel the amount of injected medical solution or the inserting distance of a piston by a difference in sliding resistance when an injection operation is performed. A syringe 1 includes a syringe barrel 11 which has an inner surface provided with a structure in which a sliding resistance F is changed step by step upon sliding a piston 32. The syringe barrel 11 includes steps which are formed at one or two or more positions of the inner surface in the axial direction so as to face from the rear end to the front end or from the front end to the rear end, and which include edges formed along the circumferential direction.

Abstract: The present invention provices a counter comprising: a first member disposed in at least a partial helical turn about a longitudinal axis of an entity whose movements and/or contents are to be counted, said first member having an indicium or indicia indicative of a count; a second member extending generally in the direction of said longitudinal axis, said second member being operatively disposed in overlapping relationship under and over one or more portions of said at least partial helical turn of said first member; and means to effect relative movement between said first and second members, said movement comprising a relative incremental rotation about said longitudinal axis.

Abstract: The present invention is directed to an automatic reconstitution drug delivery device. The inventive device effects simple and automatic reconstitution of a dry drug. To effect reconstitution, a user displaces a release button which causes first and second chambers of a drug cartridge to communicate, resulting in automatic mixing of a diluent and dry drug to effect reconstitution of the dry drug. The user then simply sets the dose volume using a dose-setting mechanism, and administers the injection in a manner typical of self-injection drug delivery devices. Whole or partial automatic priming can be also achieved by the device.

Abstract: A drug delivery device includes a cartridge (211) for storing a medicament and a needle (203) communicating with the cartridge (211) for injecting a medicament dose. A rack (241) is movably disposed in the cartridge (211) and is engageable with a stopper (213) for expelling the medicament dose from the cartridge (211). A lever assembly (231) has a lever arm (233) connected to a lever gear (230). The lever gear (232) is engaged with the rack (241) such that rotation of the lever arm (233) rotates the lever gear (232) during injection of the medicament dose, thereby moving the rack (241) and stopper (213) through the cartridge (211) to deliver the medicament dose.

Abstract: A dosing device for an injection device, the dosing device including an actuating element for adjusting and/or dispensing a dose from the injection device, a thrust element for generating a forward movement for discharging a dose and a coupling to which the actuating element and the thrust element are coupled such that a rotational movement of the actuating element is transmitted directly to the thrust element and an axial movement of the actuating element is different than an axial movement of the thrust element.

Abstract: The present invention relates to a dose setting mechanism intended to be used in a medicament delivery device, comprising an elongated tubular distal housing (16) having opposite distal and proximal ends, wherein said distal housing comprises threads (14) on its inner surface, a first window (30), a second window (32), and at least one opening (38) on its elongated surface; a tubular dose limiting member (10) having opposite distal and proximal ends, wherein said dose limiting member comprises a first thread segment (12) on its outer circumference surface at its proximal end intended to cooperate with corresponding threads on the inner surface of the distal housing, first indicia (18) on its outer circumferential surface, a stop surface (42) at its proximal end, and a number of protrusions (20) arranged equidistant to each other along the circumference on the outer surface at its distal end; a tubular dose setting member (22) having opposite distal and proximal ends, wherein said distal housing is coaxially a

Abstract: The present invention relates to injectors, such as pen-type injectors, that provide for administration of medicinal products from a multidose cartridge and permit a user to set the delivery dose. The injector may include a housing, a cartridge containing medicinal product, the cartridge being retained within the housing, means for selecting a dose of medicinal product to be expelled, and means for expelling the selected dose of medicinal product. The housing may be a unitary housing within which the means for selecting a dose and the means for expelling the selected dose are moveably retained. Alternatively, the injector may include a housing, a piston rod, an insert located in the housing and through which the piston may rotate, ratchet means, a dose dial sleeve, a drive sleeve, a button located on the drive sleeve and rotatable with respect to the drive sleeve, and clutch means which upon depression of the button prevents rotation between the dose dial sleeve and the drive sleeve.

Abstract: The invention relates to a device for injecting liquids, more particularly liquid medicaments or hormone preparations, for example insulin, said device comprising a housing part in or on which a cartridge containing the liquid can be arranged, wherein the housing part or the cartridge has a needle seat designed for releasable attachment of a needle holder carrying a needle, and wherein the cartridge, upon release of the needle holder from the needle seat, is held fixed in position in or on the housing part. In order to release the needle holder, a release element is provided that engages on the needle holder and that can be activated by an actuating element.

Abstract: A fill and purge system for a drug reservoir is disclosed. The fill and purge system comprises a positive pressure source, a negative pressure source, a first valve, a second valve, and a delivery channel. The positive pressure source is fluidly connected to the first valve. The negative pressure source is fluidly connected to the second valve. The first and second valves are fluidly connected to the delivery channel. A method of filling and purging a drug reservoir is also disclosed.

Abstract: A pen body assembly (100) for a drug delivery pen includes a pen body (101) and a dose setting body (111) movably connected to the pen body (101). A knob (109) is connected to the dose setting body (111) for moving the dose setting body (111) relative to the pen body (111). One of the pen body (101) and the dose setting body (111) has a thread groove (107) having a varied pitch disposed thereon and the other one has a protrusion (105) engaging the thread groove (107).

Abstract: The present invention relates to electronically assisted drug delivery devices (100). The drug delivery device may include a Gray code type detector for sensing dosage data, wherein the detector comprises a code track consisting of a sequence of alternating markings and a plurality of detectors that are mutually spaced in a direction extending along the code track. The drug delivery device may also include a dosage selector (260) which is moved in a proximal direction upon dose setting and in a distal direction upon dose injection, where the dosage selector is latched in the end of dose position by a latching element, the latching element actuating an end of dose switch for signalling the end of dose state. The drug delivery device may also incorporate power-management arrangements which effectively minimizes power consumption for the incorporated electronic circuitry.