Abstract: A fluid mixing device includes inlet ports in fluid communication with respective source containers, an inlet check valve, a mixing container in fluid communication with the inlet check valve, a discharge port in fluid communication with a target container, and a discharge check valve in fluid communication with the mixing container and the discharge port. Responsive to a negative pressure at the mixing container, fluid is drawn from the respective source containers through the inlet ports and through the inlet check valve and into the mixing container, while the discharge check valve precludes drawing of fluid from the target container. Responsive to a positive pressure at the mixing container, fluid is expelled from the mixing container through the discharge check valve and into the target container, while the inlet check valve precludes discharge of fluid from the mixing container to the inlet ports and the source containers.

Abstract: The present invention relates to an autoinjector device (10) for use in combination with a syringe (30), said syringe comprising a movable plunger; a needle; and a tubular needle shield (34). The claimed autoinjector device (10) comprises: an elongated housing having a proximal (11) and a distal end (12); a drive mechanism; a syringe holder (40) in order to support the fragile syringe and to prevent damage to the syringe. The invention furthermore relates to a method for assembly of the autoinjector device according to the invention.

Abstract: A device for dispensing a fluid product, having a body with a dispensing orifice, two removable reservoirs each containing a single dose of fluid product, a dispensing mechanism, and an actuating mechanism. The reservoirs are closed before the dispensing device is actuated. The body has a mechanism for opening each reservoir and adapted to open the reservoirs during actuation of the device. The reservoirs each form a sealed unit which is separate from said body, each reservoir filled with a respective fluid product and hermetically sealed before installed in the body. The body has a receiving mechanism for lateral installation of the reservoirs in the body.

Abstract: A device and method for aspirating graft tissue and delivering the graft tissue to a target delivery site (for example, when performing Descemet's membrane endothelial keratoplasty). In one embodiment, an injector comprises a cylinder and a plunger at least partially located within the cylinder, the plunger being rotatably advanceable and retractable within the cylinder. In one aspect of the embodiment, rotating the plunger in a first direction within the cylinder controllably aspirates a graft tissue into the injector and rotating the plunger in a second direction opposite the first direction controllably ejects the graft tissue from the injector.

Abstract: An allergen-loadable microneedle cartridge is disclosed. The cartridge includes at least one substrate, a plurality of microneedles in a microneedle layout protruding from at least one substrate, and fillable allergen sites corresponding to the microneedle layout. The fillable allergen sites and microneedle layout are configured such that the microneedles can penetrate subject skin and deliver pharmacologically active doses of allergens in a minimally invasive process. A planar allergen filling system for loading the allergen-loadable microneedle cartridges is also disclosed. The system has a loading section with spaced-apart allergen loading sites that correspond to the microneedle layout of the microneedle cartridge. Filling wells having allergen deposition areas larger than the allergen loading sites transfer deposited allergen to the allergen loading sites through capillary channels.

Abstract: A system for injecting includes a syringe body, a syringe interior, a syringe flange, and a stopper member and an injectable fluid disposed in the syringe interior. The system also includes a plunger member coupled to the stopper member. The system further includes a finger flange removably coupled to the syringe flange, the finger flange defining a pair of side openings and a pair of bumps adjacent respective side openings. Moreover, the system also includes a swing spacer rotatably coupled to the finger flange, the swing spacer defining a pair of arms, a pair of pivot pins, two pairs of slots, and a pair of indentations. The swing spacer is configured to define a distance of movement of the plunger member relative to the syringe body along a longitudinal axis of the syringe body, thereby defining a dose of the injectable fluid.

Abstract: A safety needle assembly includes a housing and a cannula hub connected within a side wall of the housing, a needle connected to the cannula and extending from the cannula hub outward from a proximal end of the housing, and a spring connected with the housing. The assembly includes a barrel connected with the spring and at least partially contained within the housing to least partially cover the cannula hub. The barrel is configured for moving, sliding, traveling, activating, relocating, or transitioning from a first mode in which the barrel is securely retracted and locked at least partially within the housing and the needle extends through an aperture of the barrel and the proximal end of the housing, to a second mode in which the barrel extends from the proximal end and beyond the needle.

Abstract: An injector device includes a housing having a slot with a locking portion and a needle unit that has a needle and a slot engagement portion that extends through the slot in the housing to an external side of the housing. The needle unit is movably mounted in the housing such that movement of the needle unit relative to the housing is restricted by the slot. The injector device also includes a cartridge that is mounted in the housing, the cartridge having a reservoir for medicament. Prior to use of the injector device, the reservoir is sealed from the needle. The slot in the housing is arranged such that the needle unit can be rotated to move the slot engagement portion out of the locking portion such that the needle unit can be moved into engagement with the cartridge to place the needle in fluid communication with the reservoir.

Abstract: An add-on for a self-injector including an adaptor and a bent fluid path is provided. The adaptor includes at least one coupling sized and shaped to couple the adaptor to a fluid reservoir. The bent fluid path is configured at a first end to penetrate tissue and coupled at a second end to the adaptor. The add-on coupled to the fluid reservoir forms an integral self-injector cartridge unit configured to be sterilized and filled with an injectable. The adaptor is configured to couple to a self-injector at least one of a plurality of reservoirs having different sizes and tip types.

Abstract: A drive mechanism for a medicament delivery device is presented having an activation rod provided with external activation rod threads having a first thread helix angle, an activation knob rotationally locked with the activation rod, wherein the activation knob is configured to be moved between a first axial position relative to the activation rod in which the activation knob is prevented from rotation and a second axial position in which the activation knob is allowed to rotate in a first direction, an axially slidable drum which is rotationally locked, a dose drum rotationally locked relative to the activation rod, wherein the dose drum is configured to rotate relative to the slidable drum, an indicator drum provided with external indicator drum threads having a second thread helix angle, wherein rotation of the activation knob in the first direction causes concurrent first rotation of the activation rod and the dose drum in accordance with the first thread helix angle.

Abstract: An injector including at least one fluid reservoir having a needle, a surface attached to skin and coupled to the fluid reservoir by at least a first joint and a second joint at least a portion of one of the joints being slidable or having interlocking arms. At least a portion of a path of translation of a slidable portion of the first joint and a portion of a path of translation of the second joint are angled in respect to each another.

Abstract: An accessory for an injection device having a safety shield and at least one flange adapted to allow a user to grip the injection device and a syringe sheath moveable relative to the at least one flange from a pre-injection position to a locked-out position. The accessory comprises a body portion comprising a recess adapted to receive the safety shield of the injection device and a slot adapted to receive the at least one flange of the injection device.

Abstract: The present disclosure provides a nasal delivery device with a device body that includes a trigger end and an outlet end. The nasal delivery device also includes a trigger assembly coupled to the trigger end of the device body, a drug container supported by the device body, and a spring-loaded activator assembly supported by the device body and disposed between the trigger assembly and the drug container.

Abstract: An adjustable dosage limiting device includes a member that interfaces to a plunger flange of a syringe and a barrel loop that slides along a barrel of the syringe. A locking mechanism, when engaged, fixes a distance between the member that interfaces to a plunger flange and the barrel loop, and hence, locks the barrel loop in place with respect to the plunger flange. Once locked in place, the adjustable dosage limiting device limits a dosage provided by the syringe based upon a distance between the member that interfaces to a plunger flange and the barrel loop as set by the locking mechanism.

Abstract: A drive mechanism for a medication delivery device containing a resilient member and having a rotation member configured to be rotated in a first direction during setting of a dose of a medication and to be rotated in a second direction during delivery of the dose, where the rotation member is coupled to a drive member that is coupled to a piston rod such that on dose delivery the piston rod is displaced in a distal direction to dispense a medicament and where the resilient member prevents movement of the drive member and the piston rod during dose setting.

Abstract: An example injector includes a rotary knob for selecting a function and setting a dosing quantity for an injection, a button located on an end of the rotary knob for initiating the injection, an electric motor, an encoder for evaluating output rotary motion of the motor, and a processor that converts the dosing quantity into a number of encoder pulses and controls operation of the motor based on the number of encoder pulses when dosage is triggered. The injector also includes a transmission coupled to the electric motor to convert a speed of the motor, a threaded spindle coupled to the transmission that moves linearly based on the output rotary motion of the motor at the speed as converted by the transmission, and a punch connected to an end of the threaded spindle. The linear movement of the spindle causes the punch to release medicament.

Abstract: A biopsy device includes a housing, a probe assembly, and an insert aid. The probe includes a biopsy needle unit, a vacuum pressure-generating device, and a flexible connection tube that connects the biopsy needle unit to the vacuum pressure-generating device. The insert aid device has a body that defines a pair of cradles configured to respectively receive the biopsy needle unit and the vacuum pressure-generating device, and configured to orient the biopsy needle unit to lie parallel to the vacuum pressure-generating device in the insert aid device for insertion of the biopsy needle unit and the vacuum pressure-generating device into the housing.

Abstract: A disposable pen needle, comprising a hub having a needle situated thereon having a patient end and a non-patient end, a removable patient end cap attached at the distal end of the hub, a removable non-patient end cap attached at the proximal end of the hub, wherein greater force is required to detach the patient end cap than is required to detach the non-patient end cap.

Abstract: Improved systems and methods for medicine delivery, and in particular, improved insulin pen needles and related devices are provided. Smart injection devices record and transfer data including medicine level, delivered dose, dose confirmation, and dose time and date. Additional data captured may include glucose concentration, insulin level, carbohydrates ingested, stress level, exercise, blood pressure, and glucose high and low excursion events. Various means of data collection and analysis are provided and systems can identify and flag patients who require intervention. Smart sleeves and add sensing capability to standard insulin pens. Pen needles are provided with sensing capability to confirm and measure doses delivered by insulin pen. A two-part pen cap include a primary sleeve that connects to the insulin pen and an end cap that provides for capturing the time of dose delivery, and monitoring the hold time for a dose delivery after plunger movement.

Abstract: The present disclosure relates to a drug delivery device for dispensing of a liquid medicament, the device comprising: a housing to accommodate a cartridge filled with the medicament and having a piston slidably displaced inside the cartridge and sealing a proximal end of the cartridge, at least one resilient member having a first end arranged at an inside facing side wall portion of the housing and having a second end (opposite to the first end to abut with the piston of the cartridge.

Abstract: An injector may include a container having a wall with an interior surface and a seal assembly with an interior surface, the interior surfaces of the wall and the seal assembly defining a closed sterile reservoir filled with a drug product. The injector may also include a fluid delivery system comprising a clean, unsheathed, rigid container needle having a point disposed only partially through the seal assembly in a storage state, and disposed through the interior surface of the seal assembly into the sterile reservoir in a delivery state. Further, the injection may include an actuator that is adapted to move the container needle from the storage state to the delivery state.

Abstract: An injector may include a container having a wall with an interior surface and a seal assembly with an interior surface, the interior surfaces of the wall and the seal assembly defining a closed sterile reservoir filled with a drug product. The injector may also include a fluid delivery system comprising a clean, unsheathed, rigid container needle having a point disposed only partially through the seal assembly in a storage state, and disposed through the interior surface of the seal assembly into the sterile reservoir in a delivery state. Further, the injection may include an actuator that is adapted to move the container needle from the storage state to the delivery state.

Abstract: A dental safety syringe comprising selectively attachable barrel and plunger assemblies, the barrel assembly desirably further comprising a needle cartridge containing a needle holder and spring, and having a distal end from which a needle can be made to project forwardly while administering a medication and then subsequently withdrawn into the needle cartridge to avoid contamination following or between injections. The needle cartridge also comprises a proximal end having a recess into which an ampule containing medication can be inserted prior to connecting the plunger assembly to the barrel assembly so that a rubber dam in the distal end of the ampule is pierced by the proximal end of the needle whenever the syringe is fully assembled.

Abstract: A drug delivery device adapted to receive a cartridge and hold it in a mounted position is provided, comprising a housing, an expelling assembly, and a front-loaded cartridge holder assembly adapted to receive and hold a cartridge in a mounted state. The assembly comprises cartridge holding means actuatable between a receiving state and a holding state, as well as a user operated actuation sleeve being rotationally actuatable relative to the housing between a loading state and an operational state, such that the cartridge holding means is actuated from the receiving state to the holding state when the actuation sleeve is actuated from the loading state to the operational state. The actuation sleeve is configured to enclose at least a portion of a mounted cartridge and is provided with inspection means allowing at least a portion of an enclosed cartridge portion to be visually inspected.

Abstract: Disclosed is an infusion device drive unit that includes a pump drive configured to operatively mechanically couple to a dosing unit to control operation of the dosing unit. The infusion device drive unit further includes a blocking member that is movable between a blocking configuration and a enabling configuration, the blocking member enabling the establishing and/or the releasing of an operative mechanical coupling between the pump drive and the dosing unit in the enabling configuration and preventing the establishing and/or the releasing of an operative mechanical coupling between the pump drive and the dosing unit in the blocking configuration. The infusion device drive unit controls the blocking member to take on the enabling configuration if the pump drive is in at least one pre-determined configuration and to take on the blocking configuration if the pump drive is in a configuration different from a pre-determined configuration.

Abstract: A filter medium includes two porous zones arranged in the form of a stack that include (i) a first porous zone, called “prefiltration”, treated with at least one reagent presenting affinity for red blood cells and leading to red blood cells being captured or agglutinated on the prefiltration zone; and (ii) a second porous zone, called “asymmetric”, presenting pore size that decreases transversely to its thickness, the portion of higher pore size being positioned towards the prefiltration zone.

Abstract: The invention relates to an adapter element for fastening a needle element to a syringe base body, the adapter element having a base body which is configured and provided for receiving the needle element, the base body having at least one through-opening for passing the needle element through and for fixing it, and the base body being configured and provided for being fastened to the syringe base body.

Abstract: An injection apparatus and training system for prophylactic, curative, therapeutic, acupuncture, or cosmetic injection training and certification. In an embodiment, an injection training system is described that includes a testing tool having a needle and a position sensor, where the position sensor is configured to obtain position information of the testing tool. The system also includes an injection apparatus configured to receive a simulated injection by the testing tool. The system includes a display device configured to receive the position information and to display position data reflective of the position information.

Abstract: In a method for closing a plurality of medical cartridges (5) a closure nest for supporting a plurality of closures is used, comprising a planar supporting plate having a plurality of receptacles having a plurality of tubular receptacles (61) and retaining structures for reliably accommodating the closures (200). In the method the plurality of medical cartridges (5) is supported in a corresponding cartridge nest. The closure nest is disposed above the cartridge nest so that the receptacles of the closure nest are precisely aligned with the receptacles of the cartridge nest. The closures (200) are then pushed downward out of the receptacles of the closure nest and into the cartridges (5), while the cartridges are supported by the cartridge nest. The closure nest can be directly fed on existing filling and stoppering machine set-ups for processing sealed prefillable syringe barrels, basically without the necessity of changing the set-up.

Abstract: A supplemental device for attachment to an injection device. A supplemental device for attachment to an injection device, the supplemental device comprising: a housing; an electromechanical switch arrangement, the electromechanical switch arrangement comprising: a main body; and a switching member, the switching member having a protrusion arranged to protrude from the main body so as to contact a surface of the injection device while the supplemental device is attached to the injection device; and a biasing member configured to bias at least a part of the main body of the electromechanical switch arrangement against the injection device while the supplemental device is attached to the injection device.

Abstract: The present disclosure relates to a medicament container assembly (11) for a medicament delivery device, comprising: an elongated body (3) configured to receive a medicament container (17) and provided with a radially flexible first gripper arm (3f) extending in the axial direction of the body (3) and an oppositely arranged radially flexible second gripper arm (3g) extending in the axial direction of the body (3), wherein the first gripper arm (3g) and the second gripper arm (3f) are configured to support a neck portion of a medicament container, and a clamp member (13) configured to be arranged radially outside of the first gripper arm (3f) and the second gripper arm (3g), to press the first gripper arm (3f) and the second gripper arm (3g) radially inwards, to prevent proximal displacement of a medicament container.

Abstract: The present invention provides rapid-acting insulin and insulin analogue formulations. The invention further provides delivery devices, particularly infusion sets, which allow for the rapid absorption of insulin and insulin analogues, as well as other active agents. Methods of using the insulin and insulin analogue formulations as well as the insulin delivery devices for treating subjects with diabetes mellitus are also provided.

Abstract: An anesthetic syringe comprising a nerve detector and an illuminated indicator. The nerve detector is configured to receive a radiative energy from a nerve in a tissue and send a signal to the illuminated indicator. The illuminated indicator shows a direction to move the syringe to a tissue location proximal to the nerve for injecting a local anesthetic drug. The syringe may accommodate a standard drug cartridge and may provide manual or automatic movement of a plunger.

Abstract: Blood collection devices having a retractable needle are provided. Activation of the retraction mechanism causes release of propellant from a propellant chamber, which drives a retraction assembly carrying the needle into a body of the device.

Abstract: Embodiments of a syringe-based device for delivering fluid include a housing, a port, the port being positioned at about the distal end of the housing, a plunger assembly, the plunger assembly including, a plunger seal, a valve, and a cannula, a first fluid reservoir, where the first fluid reservoir retains a first type of fluid, a syringe including a syringe body, a syringe port, a plunger, and a second fluid reservoir, the second fluid retaining a second type of fluid, and where the syringe transitions from a first configuration in which a first portion of the first fluid type is delivered through the port, to a second configuration in which the second type of fluid in the second fluid reservoir is delivered through the port, to a third configuration in which a second portion of the first fluid type is delivered through the port.

Abstract: A mechanism in the body is used to drive a piston rod and comprises means for guiding the movement of the piston rod relatively to the body while delivering the drug. Further means are provided for releasing the piston rod from the means for guiding the movement, thus enabling a reset of the piston rod to a start position, especially after the receptacle has been emptied and is to be refilled. The device is constructed in such a manner that a reset of the piston rod is facilitated.

Abstract: A drug injection device is disclosed. A drug injection device, according to the present invention, comprises: a plunger which is connected to an ampoule filled with an injectable solution and applies pressure to the injectable solution in the ampoule; a manual plunger handle which is connected to one side of the plunger and manually applies pressure to the plunger; and an automatic plunger pressurizing unit which is selectively connected to the plunger in a position adjacent to same and automatically applies pressure to same by means of power.

Abstract: A device for transferring a portion of a liquid contained in a container, the device having a hollow needle for penetrating through the plug of the container; a pressure chamber for pressurizing a fluid, the chamber having the needle passing therethrough and being provided with a septum; and an approach system for causing the hollow needle and the septum to approach each other so as to increase the pressure of the fluid as a result of the approach.

Abstract: Methods and apparatuses are disclosed with regard to syringe-transfer of a solution or other fluid, optionally with a guidance bearing, within a standard or non-standard carpule, optionally having sealed top ends and measurement gradations, i.e., indicia. One embodiment is a non-standard carpule barrel having a top portion, a bottom portion, and a barrel portion therebetween. The top portion includes an opening for receiving a syringe plunger and at least a first portion for connecting to an upper portion of the syringe. The bottom portion includes another opening capable of holding a bottom end of the carpule, wherein the carpule may be a standard carpule or a non-standard carpule. The barrel portion is located between the top portion and bottom portion, and includes a cradle, which has a length capable of holding a standard or a non-standard carpule, which has a greater width than a standard carpule.

Abstract: A cartridge assembly for use with a drug delivery device is specified. The cartridge assembly comprises a cartridge with a retention cap and a cartridge holder. According to one aspect, the cartridge and the cartridge holder may be configured to be fixed to each other in a predetermined position According to another aspect, the retention cap comprises at least one coding feature configured to affix said cartridge to said cartridge holder in the predetermined position by the mating of said coding feature with a corresponding coding feature on the cartridge holder.

Abstract: Provided is a manual drive unit for use with a cassette unit comprising a cassette unit housing containing there within a syringe comprising a barrel for containing a volume of a liquid drug formulation; a hollow needle at a front end of the barrel, the hollow needle defining a needle tip for dispensing of the liquid drug formulation; and a plunger that is axially movable within the barrel. The manual drive unit comprises a manual drive unit housing defining a docking cavity and a needle delivery aperture, wherein said docking cavity is arranged for docking receipt of the cassette unit at a docking position; and received by the manual drive unit housing and axially movable relative thereto, a manually operable drive transfer element for transferring axial drive to the plunger of the syringe for moving the plunger into the barrel of the syringe to eject at least part of the volume of liquid drug formulation.

Abstract: The invention discloses a disposable array-type micro injection needle head which comprises a lower needle seat which is configured as a cylindrical column opening at one end and having a top cap at the other end and which is configured to be connected with an injection reservoir; an upper needle seat which is located above the top cap of the lower needle seat with a cavity formed between the upper needle seat and the top cap; a through-hole formed in the top cap which is configured for communicating the cylindrical column with the cavity, wherein a pipetting needle is mounted in the through-hole which has one end communicated with the cavity and the other end located in the cylindrical column and which is configured for extracting injection from the injection reservoir into the cavity; and at least two needle tubes mounted in the upper needle seat, each of which has one end comprising a needle tip for puncturing and for injecting the injection and the other end for mounting on the upper needle seat and for c

Abstract: A needle housing having a distal end which is removably connectable to a source of injectable fluid and a proximal end for contacting a patient, as well as to an injection apparatus comprising the needle housing. The needle housing comprises (a) a hollow needle through which the injectable fluid is deliverable to the patient, the needle having a proximal end for insertion into body tissue of the patient, and (b) a chamber having an open proximal end, the chamber surrounding at least part of the needle and extending proximally beyond the proximal end of the needle to the open proximal end. The open proximal end of the chamber is deformable and is moveable relative to the needle from a position in which the chamber extends proximally beyond the proximal end of the needle to a position in which the proximal end of the needle extends proximally through the open proximal end of the chamber.

Abstract: A medicament delivery device includes a housing with a compartment for a medicament container, an injection needle arranged to housing and connectable to the medicament container for delivering a dose of medicament, a manually operated activation mechanism, an actuation mechanism operably connected to the activation mechanism and configured to extend the injection needle, upon activation of the activation mechanism, from a first position inside the housing to a second position for penetrating a patient, a plunger rod in the housing configured to act on the medicament container for delivering a dose of medicament through the injection needle, a driver configured to acting on the plunger rod for delivering the dose, and a needle cover operably arranged in the housing between a position inside the housing and an extended position outside the housing for shielding the injection needle when the injection needle is in the second position.

Abstract: The invention inter alia relates to a dispense interface for an ejection device. The dispense interface comprises at least two inlets, at least one outlet and a part having multiple portions; wherein the multiple portions are connected by living hinges such that the multiple portions are foldable towards each other; wherein the multiple portions are configured to form a fluid channel arrangement between functional surfaces of the multiple portions facing each other when the multiple portions are folded towards each other; wherein at least two functional surfaces of the functional surfaces are inclined to each other when the multiple portions are folded towards each other; and wherein the fluid channel arrangement is configured to provide fluid communication between the at least two inlets and the at least one outlet.

Abstract: A coding system for a drug reservoir, where the drug reservoir is intended for use with a reservoir holder of a drug delivery device. The coding system includes a collar fitted around the drug reservoir. The collar includes a coding feature that is configured to pass through a corresponding coding feature provided by the reservoir holder of the drug delivery device.

Abstract: A plug of an artificial insemination tube for livestock breeding includes a leading portion and a viewing portion, each having different color layers or different hardness layers, and being formed by stacking and combining different foam layers. In an artificial insemination for livestock breeding, the plug installed at the front of a sperm delivery duct is inserted into a reproductive organ of the livestock, and secretion or fluid is attached and shown on surfaces of the plug leading portion and the viewing portion with different colors to achieve the effect of detecting the physical and physiological conditions of the livestock. In addition, the leading portion is a foam layer with relatively greater hardness, density, and smoothness, so that the plug may be entered into the female livestock body more easily, and the injection hole will not be deformed easily, so as to improve the smoothness and efficiency of the artificial insemination.

Abstract: A syringe is provided with an assembly received on the distal end for adjusting the penetration depth. In embodiments, the assembly includes a collar attached to the syringe hub which moves with respect to the needle between axial positions depending on the desired needle penetration depth. The adjustable penetration depth syringe is useful in the context of self-administered drugs such as insulin, where a longer length needle is needed to fill a syringe from a vial, but a shorter penetration depth is preferred for administering a subcutaneous injection.

Abstract: The invention relates to a syringe closure for a syringe having a basic body, a terminal extension that extends from the basic body, which has a free end and a base arranged on the basic body. A recess is provided on the extension at a distance from its free end. The syringe closure for closing off the syringe can be attached in such a way on its extension via its free end that the syringe closure overlaps at least one recess of the extension. The syringe closure is characterized by a locking device having at least one locking element, which assumes a release position in a first functional position after the attachment of the syringe closure on the extension, and ensures a positive engagement with at least one recess on the extension in a second functional position, the locking position, and thus lockingly holds the syringe closure on the extension.

Abstract: A method and apparatus are disclosed for delivery of a drug to a recipient. In some embodiments, the delivery apparatus may unseal a drug containing reservoir. In some embodiments, the delivery rate may be controlled and/or adjustable. Optionally the apparatus may be disposable. Optionally, the apparatus may have a low profile and/or be wearable and/or attachable to the recipient. Optionally, discharge of the drug and/or unsealing of the reservoir may be driven by a plunger moving parallel to the base of the apparatus. Optionally, the apparatus may release a hypodermic needle into the recipient. Optionally, release of the hypodermic needle may be in a direction non-parallel and/or orthogonal to the direction of movement of the plunger. Optionally, prior to release, the hypodermic needle may be preserved in an aseptic state by a needle opening septum sealing a needle opening. Optionally, upon release, the hypodermic needle may pierce the needle opening septum.