Abstract: The present invention relates to a cartridge for a drug delivery device, comprising a barrel of substantially cylindrical shape and at least one piston arrangement displaceably arranged in the barrel, wherein the piston arrangement occupies at least 20% of the volume confined by the barrel.

Abstract: A device which facilitates the absorption of nicotine in order to reduce the incidence of tobacco smoking is disclosed. The device includes a tube defining an interior space. The tube has a first end with an opening and a second end. An inhalable, flowable liquid or gel composition is disposed in the interior space of the tube. The composition may include water, at least one vitamin, a flavoring agent, and nicotine. The flavoring agent may include an intense sweetener such as sucralose, and a natural or artificial fruit flavor. A user inhales on the first end of the tube of the device as a substitute oral activity to tobacco smoking and thereby ingests a source of nicotine that reduces the withdrawal symptoms experienced when smoking is stopped.

Abstract: The present invention relates to a drug delivery device for administering a predefined dose of a medicament comprising of housing. The housing comprising of a body to accommodate a drive mechanism, a cartridge holder to accommodate a cartridge having a piston slidably disposed therein in an axial direction (z), and an interconnection between cartridge holder and body, said interconnection having at least one displaceable or resiliently deformable latch element to mate with a corresponding bearing, wherein the latch element is displaceable or deformable in a direction (z, w) extending substantially parallel to a circumferential side wall of the body or cartridge holder.

Abstract: A medical delivery system (100) having a container (102) and a dosing assembly (104), and wherein one of the container and the dosing assembly comprises a rotatable element (106) adapted to engage the other one of the container and the dosing assembly. A container suitable for use in said medical delivery system. A dosing assembly suitable for use in said medical delivery system.

Abstract: A device for administering a product (e.g. a medicinal or therapeutic substance), the device including a receptacle for the product or constituents of the product and a casing, wherein the receptacle and casing are engaged, and an outer sleeve, wherein the casing can be moved relative to the receptacle into the outer sleeve.

Abstract: A modular administration appliance including a reusable base unit and a replaceable cartridge detachably connected to the base unit and including a container for a substance and a rotatable transmission element, the base unit including a drive device by which a rotary movement is transmitted between the base unit and the cartridge, and a driving element displaceable in a rotary movement about a rotational axis by the drive device, wherein a rotation of the transmission element causes the ejection of at least a portion of the substance from the container. In some embodiments, the transmission element at least partially surrounds the drive device, and/or the drive element and the transmission element are detachably connectable to each other for transmitting the rotational movement.

Abstract: The invention relates to a process for producing a bone-regeneration material. According to the method, a bio-compatible, open-pored body is exposed to a vacuum and osteoinductive and/or osteogenic substances are absorbed into the pores of the body, for example by means of a vacuum generated therein. It is thus possible to produce a bone-regeneration material, which contains osteoinductive and/or osteogenic substances in the pores of the bio-compatible body, said substances acting as a network structure for new somatic cells that are to grow into the porous body.

Abstract: An injection device with a housing and an operating element or coupling element mounted in the housing in such a way that the operating element or coupling element may be retained in a first position by a first holding connection and may be displaced into a second position that is axially offset relative to the first position after introducing an ampoule. In some embodiments, the operating element or coupling element may be retained by a second holding connection in the second position.

Abstract: A device which facilitates the absorption of nicotine in order to reduce the incidence of tobacco smoking is disclosed. The device includes a tube defining an interior space. The tube has a first end with an opening and a second end. An inhalable, flowable liquid or gel composition is disposed in the interior space of the tube. The composition may include water, at least one vitamin, a flavoring agent, and nicotine. The flavoring agent may include an intense sweetener such as sucralose, and a natural or artificial fruit flavor. A user inhales on the first end of the tube of the device as a substitute oral activity to tobacco smoking and thereby ingests a source of nicotine that reduces the withdrawal symptoms experienced when smoking is stopped.

Abstract: A power injector syringe assembly (110) is disclosed. The power injector syringe assembly (110) includes a power injector syringe (112) and coupling (130) that are permanently joined. The coupling (130) includes a wedge-shaped mounting flange (144) to facilitate installation of the assembly (110) on a syringe mount (200) of a power injector. The coupling (130) also includes at least one coupling member (150) to facilitate removal of the assembly (110) from the syringe mount (200).

Abstract: The present invention is directed to an automatic reconstitution drug delivery device. The inventive device effects simple and automatic reconstitution of a dry drug. To effect reconstitution, a user displaces a release button which causes first and second chambers of a drug cartridge to communicate, resulting in automatic mixing of a diluent and dry drug to effect reconstitution of the dry drug. The user then simply sets the dose volume using a dose-setting mechanism, and administers the injection in a manner typical of self-injection drug delivery devices. Whole or partial automatic priming can be also achieved by the device.

Abstract: An external infusion device that infuses a fluid into an individual's body includes a housing, a reservoir, a drive system, a power supply, electrical elements, and a tab. The reservoir contains the fluid, and the drive system forces the fluid from the reservoir. The electrical elements control the power to the drive system to regulate the rate that fluid is forced from the reservoir. The tab mates with the housing, and contains at least one electrical element. The tab is removable, and may be replaced with a different tab. The different tab may change the rate fluid is forced from the reservoir. A tab may be removed from one external infusion device and installed in a different external infusion device. The tab may be limited to use in a predetermined number of external infusion devices and may include a power supply.

Abstract: An injection device having parts, the relative movement of which causes the active substance to be injected. For this purpose, a receptacle, into and in which a carpule/syringe can be inserted and mounted, is retained in a housing, the receptacle can be moved by means of a carriage, and a plunger that applies a force to the piston/s of the carpule/syringe is movably retained in the receptacle. A traction rope which is deflected by means of a roll mounted on the carriage is provided for performing the pricking stroke, injection stroke, and retracting stroke. One end of the traction rope is connected to the receptacle while the other end thereof is connected to a tension spring that is retained on the housing. Mechanisms between the housing, the receptacle, the plunger, and the carriage control the reciprocal coupling thereof to the traction rope.

Abstract: An injection device is provided. The device includes a housing having a first end defining a first opening. A plunger is received within the first opening of the housing to move between first and second positions. A cartridge is disposed in the housing and has an interior serving as a reservoir for a drug. A delivery needle is disposed within the housing and is in fluid communication with the reservoir via an interruptible fluid channel. A locking mechanism is disposed in the housing. In the first position of the plunger the delivery needle is enclosed by the plunger and in the second position of the plunger the delivery needle is placed in an injection position and the plunger activates the locking mechanism whereby when the plunger returns to the first position the locking mechanism prevents the needle from being placed in the injection position.

Abstract: Various embodiments of drug delivery devices and methods of assembling such devices are provided. In one embodiment, a drug delivery device for dispensing medicament comprises a medicament cartridge, wherein the cartridge comprises (i) a distal end, (ii) a proximal end that is opposite the distal end along a body axis of the cartridge, and (iii) a movable piston arranged substantially at the proximate end of the cartridge. The drug delivery device further comprises a piston rod having a distal end for axially moving the piston in the distal direction during dispensing of a set dose of medicament, wherein a relative axial distance between the distal end of the piston rod and a proximal face of the piston is set during assembly of the drug delivery system. The relative axial position between may be set such that the piston rod and the proximal face of the piston abut each other.

Abstract: Medical devices having restrictive access, and methods thereof are provided.

Abstract: Injection systems comprising a powered injector and one or more hazardous agents are disclosed.

Abstract: A drug delivery device (1) comprises a housing (2) and a cap (3) attachable onto the housing (2). The cap (3) comprises one or more snap features (33) to attach the cap (3) onto the housing (2) and one or more orientation features (34) to define the orientation of the cap (3) relative to the housing (2). At least one of the orientation features (34) is located at a rigid part of the cap (3) and at least one of the snap features (34) is located at a less rigid part of the cap (3).

Abstract: A disposable injector (4) having a two-chamber system (99), wherein at least one first chamber (105) is part of a piston-cylinder unit (100) that can be accommodated in the disposable injector (4), and wherein the second chamber (255) is part of a chamber (250) which is at least temporarily closed by means of a stopper (257) and inserted into a container adapter (200) detachably mounted on the disposable injector (4), or part of a piston-cylinder unit (254), and wherein the container adapter (200) comprises a connecting tube (242) initially closed by means of a cap (290). To this end, on the side oriented toward the second chamber, the stopper has a recess (271), into which at least one stopper channel (275) connecting the lateral surface (277) of the stopper to the recess (271) opens.

Abstract: A fluid transfer device including a cartridge having a plurality of needles, an advancer operative to selectably advance any of the plurality of needles in the cartridge to a needle deployment position, and a syringe operative to convey fluid through the needle in the needle deployment position.

Abstract: A dispenser device comprising a pistol housing, a needle direction control mechanism, a boost mechanism, a quantification control mechanism, and a combination of the pistol housing, the needle direction control mechanism, the boost mechanism, and a syringe positioning mechanism or a holding ring embodies the present invention with features and advantages shown as follows, (1) Uniform injection of agents synchronously mixed by not less than two contents; (2) Mixed agents not exposed in air; (3) Uniform injection, high air tightness, injection direction controlled by easy turning, smooth and convenient operation, high powerful operation via shifts of a push rod driven by a pressed trigger, promoted yield rate, assembly easily constructed, reduced manufacture cost, and convenient maintenance.

Abstract: A delivery device includes a durable housing portion and a separable disposable portion that selectively engage and disengage from each other. The disposable housing portion secures to the patient-user and may be disposed of after it has been in use for a prescribed period. Components that normally come into contact with a patient-user or with infusion medium are supported by the disposable housing portion, while the durable housing portion supports other components such as electronics and a drive device. A reservoir is supported by the disposable housing portion and has a moveable plunger that operatively couples to the drive device, when the disposable and durable housing portions are engaged.

Abstract: A drive mechanism for a drug delivery device which can be switched between a normal operation state and a reset state comprises of a housing having a proximal end and a distal end, a rotation member which is adapted to rotate in a first direction and in a second direction with respect to the housing, a drive member, wherein in the normal operation state the rotation member is coupled with the drive member so that the drive member follows rotational movement of the rotation member in the second direction, a piston rod, wherein in the normal operation state the piston rod is displaced in a distal direction with respect to the housing when the drive member rotates in the second direction with respect to the housing, a stop member, wherein in the normal operation state the stop member is coupled with the drive member so that the stop member prevents rotational movement of the drive member with respect to the housing in the first direction, and a separation member for switching the operation state, the separation

Abstract: An injector 12 includes a plunger 17 for expelling drugs from a cartridge 10 which can be inserted into the injector 12. An actuator 27 is provided for operating an escapement mechanism 21 to control the movement of the plunger under a drive force and hence the expelled drug.

Abstract: An injection device including a drive unit, a delivery unit, a dosing unit, a trigger for triggering an injection, a first coupling mechanism between the drive unit and the delivery unit, and a second coupling mechanism between the dosing unit and the drive unit, wherein the drive unit is tensioned by a rotation of the dosing unit and when the drive unit is tensioned the first coupling mechanism is disengaged and the second coupling mechanism is engaged, and wherein when an injection is triggered first the first coupling mechanism is engaged and then the second coupling mechanism is disengaged. In some embodiments, the device may include a third coupling mechanism which only releases the delivery unit after the engagement and disengagement which follow a triggering.

Abstract: The invention relates to an injection device for the needle-free injection of a medium. Said injection device comprises an injector device and an ampoule unit, said ampoule unit comprising a base (4) holding the medium to be injected. Said base comprises a jacket (5) which exerts pressure on the base, and jacket completely enveloping the base in the longitudinal axial direction.

Abstract: A hazardous agent injection system including from about 0.02 ml to about 4.0 ml of methotrexate at a concentration of from about 7.5 mg/ml to about 150 mg/ml; a needle-assisted jet injector including a container configured to contain the methotrexate; a injection outlet member associated with the container; an injection-assisting needle coupled to the injection outlet member; a firing mechanism associated with the container; an energy source associated with the firing mechanism; and a trigger mechanism associated with the firing mechanism, wherein the needle-assisted jet injector is configured to eject the methotrexate from the injection outlet member such that the Cmax, Tmax and bioavailability of the needle-assisted jet injected methotrexate falls between about 80% and about 125% of the Cmax, Tmax and bioavailability of methotrexate delivered by a hand-powered syringe.

Abstract: The present invention provides a reservoir compartment adapter for use with a fluid delivery device. The adapter includes a first end adapted for coupling with a fluid delivery device, a second end adapted for coupling with a connector, and a structure between the first end and the second end including an interior space for receiving the reservoir, wherein an extended reservoir compartment for accommodating the reservoir is adapted to be formed when the first end is coupled to the fluid delivery device, and the reservoir is adapted to be secured in the extended reservoir compartment when the connector is coupled to the second end. The adapter allows a user of a delivery device accommodating reservoirs of a certain size to manage periods where increased medication dosage is needed without the burden of carrying a larger delivery device for accommodating reservoirs filled with the increased dosage.

Abstract: An actuating mechanism for a hypodermic syringe comprises a flexible tongue (48) allowing the actuating mechanism to be bent to receive a cartridge (10) of injectant closed at its forward end with a septum (14) and at its rearward end with a slidable bung (18). The forward end of the cartridge (10) is fitted into a socket (36) wherein the tail (34a) of a hypodermic needle (34) pierces the septum (14) to access the injectant. With the cartridge (10) fitted, the tongue (48) is straightened, and a spring clip (50) holds the cartridge (10) in position. A plunger (38) can then be depressed, though a guide (42), to drive the bung (18) forward and make the injection. The cartridge (10), which may be a conventional cartridge of any kind, keeps the assembly rigid in use, and the whole assembly is disposed of after a single use, without dismantling.

Abstract: The present invention provides a syringe device including a needle, a syringe body, and a syringe adaptor between the needle and the syringe body. This syringe adaptor includes a reservoir and a plunger configured to move into and out of the reservoir in a direction perpendicular to the longitudinal direction of the needle. The position and direction of travel of the plunger in the syringe adaptor allows a user of the syringe of the present invention to safely and accurately operate the syringe with one hand.

Abstract: A device for the dosed administration of a fluid product including a housing, a conveying device for the product, a drive element influenced by the selection of a product dose, a coupling input member coupled to the drive element, a coupling output member coupled to the conveying device, a retaining device which maintains the coupling elements in a maintaining position uncoupled from each other, wherein at least one of the coupling elements is displaceable by a coupling movement from the maintaining position into a coupling state, and wherein a driving force of the drive element causes a delivery movement of the conveying device via the coupling elements.

Abstract: A device for administering a liquid preparation comprising a pharmaceutical agent, particularly a contrast agent, in the form of a bolus. The device comprises in particular a core cylinder and an external cylinder, the core cylinder comprising a conduit (107) and a cylindrical reservoir (108) cooperating with a respective plunger (109), wherein the plunger is modified in order to operatively engage with guiding means (300) provided on the external cylinder.

Abstract: An injection device has a housing (34), and a carpule container (44) for receiving a carpule (50) having a fluid (52) to be injected and having a piston (48) displaceable in said carpule (50). It further has a piston rod (38) with end plate (46?) which serves, in the context of an injection, to displace the piston (48) of a carpule (50) inserted into the carpule container (44) and thereby to eject fluid (52) from the carpule (50). In order to minimize patient error in adjusting the amount of fluid medication (52) to be injected, the mechanism includes a first component (68) and a second component (92) which link (98) and interact with each other, to control when the carpule container (44) can rotate with respect to the housing (34), and to prevent creation of an axial gap (62) between end plate (46?) and piston (48).

Abstract: A one-time use device to deliver preservative-free follicle stimulating hormone (FSH) solution is disclosed. The device includes a needle covered by a sliding needle shield, which covers the needle in all modes of the device. The device can be placed into a ready-to-use position in four or fewer user steps. The device has a knob for setting a desired dose of FSH. The knob includes longitudinally spaced elements respectively corresponding to the lock position and the seven or fewer discrete dosing positions. The device locks after one use and cannot be reused thereafter.

Abstract: An attachment part with a coupling part by means of which coupling part the attachment part can be attached to a dispensing unit. The coupling part has a female cone area, with a continuous inlet opening, and a locking structure arranged around the female cone area. The female cone area can be pushed onto a male cone area of the dispensing unit, in order thereby to connect the attachment part to the dispensing unit. The locking structure serves to secure the attachment part on the dispensing unit. The first coupling part additionally has a rotation element, which is rotatable concentrically about the female cone area and on which the first locking structure is formed. The rotation element has an actuating element, which serves to rotate the rotation element relative to the female cone area.

Abstract: The present invention relates to a mixing syringe device for delivering a medicament or medical composition to a site of interest. The mixing syringe device generally includes a multi-chambered open lumen and optionally a sectioned plunger. The open lumen has at least two longitudinally oriented chambers within the interior of the lumen, and the optional sectioned plunger has at least two longitudinally oriented extensions corresponding in configuration to the at least two longitudinally oriented chambers of the open lumen and configured to be reciprocatably disposed in the chambers of the open lumen. Each compartment of the lumen is configured to store a medicament component or medical composition component in its interior. In certain embodiments, each compartment is sealed at one end by a movable stopper mechanism and sealed at the other end by a sealing mechanism capable of temporarily or otherwise opening. Methods of use are also provided.

Abstract: A medical fluid injector, replaceable syringe, and coupling mechanism to engage the syringe plunger to the plunger drive ram of the injector are provided wherein coupling involves a cam cleat-like mechanism, thereby allowing for cooperative movement between the plunger drive ram and syringe plunger. The coupling mechanism of the plunger drive ram is provided with first and second movable members, each having toothed, arcuate surfaces, while the coupling mechanism of the syringe plunger is provided with a knurled cavity. Disengagement of the coupling mechanism is facilitated by translational movement of a face plate located on the forward end of the injector housing.

Abstract: A hypodermic injection system particularly for use in mass immunizations having a handpiece with a grasping mechanism for holding ampules filled with injectate, a plunger for driving into the ampule to discharge the injectate in an injection process, an injection spring mechanism for driving the plunger, a motor and/or manual mechanism for cocking the injection spring mechanism, and an ampule ejection mechanism for ejecting ampules after use under control of a release mechanism. Ampules can be loaded, used and ejected without contact by the user of the system or the patient being injected. Also disclosed are a filling station for filling ampules through their injection orifices, and an arming device for setting the injection spring. Ampules are disclosed having a piston which is drivable towards an orifice to discharge injectate through the orifice. Ampules are also disclosed having enlarged proximal portions for easy grasping by the grasping mechanism of the injector.

Abstract: A cartridge for radiopharmaceutical packaging includes a low UV-absorbing plastic barrel, closed at one end by a cap and at the other by a piston. A shoulder cooperates with the barrel in a double-level snap-on system with a cavity cooperating with an injection fitting sleeve to make a seal. At a first end the cap has a peel-off porous liner covering the cavity. Radial fins protrude inside the cavity, for screwing the injection fitting and second radial fins protrude outside of the cap to fix to a cartridge protection shield. A second end minimizes a shadow area of UV flash lamp sterilization and ensures clearance for inserting an injection spike. The second end has a reduced wall thickness pierced by the spike during set up for dispensing of the pharmaceutical. An external cylindrical zone at the second end ensures leak tightness between the cap and the barrel.

Abstract: A refillable injection device (1) having a dose setting mechanism with a dose setting member (4) and a dose rod (11). The dose setting member and the dose rod engage during normal operation of the injection device, and they do not engage during change of cartridge. The dose setting member and the dose rod need to be moved into engagement when a new cartridge is inserted in the injection device. Thereby there is a risk that stress is build-up in the piston rod. In order to prevent this, the cartridge holder is operatively connected to the dose rod in such a manner that when a cartridge is being inserted in the cartridge holder, the dose rod is caused to move along with the piston rod in an axial direction, at least while the dose setting member and the dose rod are moved into engagement.

Abstract: In various embodiments, the present disclosure provides an injection system for injecting a fluidic treatment substance into an orifice of an animal. In various implementations the system comprises a treatment cartridge having a hollow body that is structured and operable to retain a treatment substance within the hollow body. The system further comprises a plunger assembly structured and operable to removably retain the treatment cartridge and controllably dispense the treatment substance from the treatment cartridge. In various implementations the injection system can additionally include an injection site cleaning adaptor that is removably connectable to the treatment cartridge and is structured and operable to clean a site in which the treatment substance is to be injected.

Abstract: A method and device for intradermal delivery of a reconstituted medicament. The device includes a chamber, which is in fluid communication with a microdevice, e.g. microabrader or one or more microneedles. A cartridge containing the medicament may be located within said chamber. At least one burstable membrane retains a medicament within the housing. The method involves the steps of positioning the device at a delivery site on the skin of a patient and intradermally administering the medicament by dispensing a diluent from a diluent source an through inlet port to rupture the membranes, reconstitute the medicament and deliver the reconstituted medicament through the microdevice to the dermal region of the skin.

Abstract: A pen needle assembly is provided herein for use with a medical injector containing an injector body and a reservoir sealed by a septum encased in the injector body. The pen needle assembly includes a hub and a needle fixed to the hub. The hub is formed to be telescopingly mounted onto a distal end of the injector body using a track that accommodates a guide key. When mounting the hub of the pen needle assembly onto the injector body, a first portion of the track is configured to receive the guide key and to guide the guide key in a straight line across sufficient distance to permit a proximal end of the needle to fully pierce through the septum, without rotation of the needle. A second portion of the track is configured to permit the pen needle assembly to be turned with the proximal end of the needle being located proximally of the septum.

Abstract: The present invention relates to drug delivery device and a and method of manufacturing a drug delivery device with a housing having a proximal end and a distal end, a cartridge adapted to accommodate a drug, a cartridge retaining member adapted to retain the cartridge, the cartridge retaining member being secured to the housing, and a spring washer being arranged within the housing so as to exerting a force on the cartridge and securing the cartridge against movement with respect to the cartridge retaining member and against movement with respect to the housing.

Abstract: A disposable clip (10) is used to releasably attach an ampoule (13) to a syringe (11). The clip (10) includes an ampoule engaging portion (19) and a syringe engaging portion in the form of a recess (17). The ampoule engaging portion (19) comprises a compressible projection which is inserted into the neck (21) of the ampoule (13). The ampoule engaging portion (19) is thereby compressed and frictionally engages the inside of the neck (21) to secure the ampoule (13) firmly to the clip (10). The clip (10) does not obscure the label on the ampoule (13).

Abstract: An expansion/compression mechanism of a piston rod assembly is composed of a bush shaft, a first cylindrical piston rod that is screwed with the bush shaft, a second cylindrical piston rod that is screwed with the first piston rod, and a piston rod holding member for housing the bush shaft and these piston rods. Therefore, the piston rods move linearly in multiple stages.

Abstract: A standard dental syringe is made up of an outer cylinder with a plunger at one end, and a carpule which contains liquid medication to be injected into a patient is replaceably positioned within the barrel and includes a needle slidably mounted at one end of the carpule in communication with the fluid medication which is contained in a fluid chamber sealed off at each end by a plug so that when the plunger is advanced into engagement with a first plug at one end of the carpule the liquid medication is delivered through the needle and upon completion of the plunger stroke, a barbed extension of the slidable first plug member will move into engagement with the needle-retaining second plug member so that upon retraction of the plunger the needle-retaining plug member will be retracted along with the slidable first plug member.

Abstract: Described is drug infusion device. The device is intended to permit the delivery of medication over an extended period of time.

Abstract: A device for dosing a substance, including at least one rotating element and at least one coding element associated with the rotating element, using which the rotational position of the rotating element can be identified, further including at least one reference element whereby a reference signal is generated at pre-set positions or changes in position, and a method for identifying the rotational position of a rotating element which serves to set a dose, wherein the rotational position of the rotating element is identified by a coding which is only read or evaluated when a reference signal is generated at pre-set rotational positions or positional transitions.

Abstract: The dispensing appliance for a multiple cartridge or syringe comprising a housing configured to receive the cartridge that has an internal thread and a rotatable portion that has a complementary thread, the internal thread and the rotatable portion cooperating in such a manner that by mutual rotation thereof, the rotatable portion is continuously displaceable relative to the housing in the dispensing direction. The housing is configured to receive the cartridge that has two adjacent storage containers, and a thrust force of the rotatable portion is transmitted to a multiple ram without any pressure relief. This arrangement allows dispensing even highly viscous materials from cartridges with little manual force under high pressure and in a precisely metered manner.