Abstract: The present invention discloses a medical injector and medicament loading system for use therewith. The medicament loading system includes cap for a medicament cartridge. The cap has a post for causing movement of the cartridge stopper toward the seal when the cap engages the medicament cartridge to thereby eliminate adhesion between the medicament chamber and the stopper. The medical injector according to the present invention includes the medicament loading system, i.e., a cartridge assembly, a needle free syringe assembly, and a power pack assembly.

Abstract: A needle syringe in one embodiment includes a needle assembly including front and rear hypodermic needles; a barrel including a first window; a tube threadedly secured to the barrel and the needle assembly respectively and including a second window and an inner circumferential tapered surface; a medicine cartridge including a rear plunger and a front plug secured to the tapered surface when the cartridge is mounted in the barrel; and a handle. The rear needle passes the tube and the plug into the cartridge. The cartridge is prohibited from slipping relative to the barrel during injection. A medical worker can view the volume of fluid in the cartridge through the windows so as to correctly determine when to stop injection. After use the tube, the cartridge, and the needle assembly are removed to be discarded, and the barrel, the wing, and the handle are adapted to re-use.

Abstract: A disposable syringe includes a barrel, a seat member held by a grip member in the barrel such that a needle cannula extends through the seat member, a carpule configured to be fitted in a rear compartment of the barrel, and having front and rear seal members to confine a sealed chamber communicated with the needle cannula for holding liquid medicament, and a plunger operable to move the rear seal member forwardly to expel the liquid medicament through the needle cannula so as to bring the carpule in a used-up position, and to further move the front seal member from the used-up position so as to remove the grip member from the seat member to thereby bring the seat member to the disengaging position. A biasing member is disposed to bias the seat member together with the carpule rearwardly so as to retract the used needle cannula into the barrel.

Abstract: An injector device for injecting or transferring a pharmaceutical product from a pharmaceutical cartridge. The injector device includes a body having a side wall having a proximal end portion and a distal end portion, the side wall having an inner surface and an outer surface, the inner surface of the side wall defining a space for receiving at least a portion of a body of a pharmaceutical cartridge therein. One or more retention members are disposed on the outer surface of the body. The injector device further includes a plunger rod having a proximal end portion and a distal end portion, the distal end portion of the plunger rod having a connection member constructed for connection to a connecting member mounted on a piston associated with a cartridge. The plunger rod has one or more receiving members formed about its length.

Abstract: A reloadable medicine injector and methods are described in which a barrel with a receiving cavity is adapted to slidably receive a syringe subassembly for axial movement therein. Upon removal of a safety and release of a syringe driver, the syringe driver moves forward and injects the syringe needle. A plurality of penetration controls are shown for controlling injection needle penetration depth. The penetration controls have an abutment and various lengths to provide different needle penetration depth positions. In one form of penetration control a sleeve is used against which the syringe or related parts contact. In another form the front return spring is used as a penetration control. A cushioning ring may be used to reduce syringe breakage. A load distribution and guide ring may be used to distribute loading applied to the syringe and help guide the moving syringe.

Abstract: A syringe or cartridge having a hollow barrel with an open end and a second end suitable for attaching a needle assembly. A master plunger assembly that includes a master plunger and a plunger member is mounted in the barrel for longitudinal movement therein. A slave plunger is mounted in the barrel for longitudinal movement therein, and is located between the master plunger assembly and the second barrel end so as to define two chambers. The first chamber a liquid chamber and is between the slave plunger and the second barrel end, and the second chamber is a pneumatic chamber and is between the slave plunger and the master plunger assembly. The liquid-containing chamber is suitable for containing a liquid to be dispensed from the syringe, and the pneumatic chamber contains a gas such as air.

Abstract: Since this syringe has projections provided on the rear surface of a flange of a syringe barrel, when it is inserted in an insertion groove of a cylinder holder, the tips of projections are compressed and the flange is fixed. Consequently, even when a solution having high viscosity is injected at higher pressure, breakage does not occur easily. Further, pressure-receiving area may also be increased by providing a guide defining mounting direction of a syringe, alternatively, a positioning mechanism may be provided so as to obtain mounting at a correct position, or the surface of a flange may be roughened.

Abstract: A method and apparatus for the storage and transfer of medical material includes a syringe having a rodless piston magnetically coupled to an actuator that is positioned along the syringe independent of the rodless piston. The syringe may also include a medical material stored in a cartridge.

Abstract: An injection device is provided. The device includes a housing having a first end defining a first opening. A plunger is received within the first opening of the housing to move between first and second positions. A cartridge is disposed in the housing and has an interior serving as a reservoir for a drug. A delivery needle is disposed within the housing and is in fluid communication with the reservoir via an interruptible fluid channel. A locking mechanism is disposed in the housing. In the first position of the plunger the delivery needle is enclosed by the plunger and in the second position of the plunger the delivery needle is placed in an injection position and the plunger activates the locking mechanism whereby when the plunger returns to the first position the locking mechanism prevents the needle from being placed in the injection position.

Abstract: A kit and needle assembly for reconstituting a quantity of a lyophilized pharmaceutical. The kit of the invention may include a reconstituting appliance having a non-transparent needle covering portion with a hollow adapted to receive the inserted stoppered end of the injection pen cartridge, which needle covering portion extends around a side-firing cannula to hide the cannula from side view. A shiftable alignment member retained within the needle covering portion at a first axial position, and shiftable to a second axial position when abutted by the injection pen cartridge during its insertion, may be included. The kit includes an injection pen cartridge including a barrel filled with a quantity of a lyophilized drug, a slidable plunger used during pen operation to eject the reconstituted drug, and a stopper penetrable by the cannula during drug reconstituting.

Abstract: A frontloaded injection device that includes a cartridge holder into which a replaceable cartridge containing a fluid is inserted. The cartridge holder includes a closing element such as a pair of claws which are displaceable in a radial direction. The closing element is provided at the front of the injection device and locks the cartridge by gripping at the neck part of the cartridge after the cartridge has been loaded into the cartridge holder from the front of the injection device. The closing element is preferably biased in an outwardly radial direction when the locking element is moved axially out of the cartridge holder.

Abstract: A device for treating a fluid-like sample, in particular whole blood, with treatment fluid. The device comprises a tubular container with a first piston and a second piston, with a piston gap between them in which the treatment fluid is located in the initial position. The device further comprises an inlet port to which a capillary can be connected and an outlet port to which a filter can be connected.

Abstract: Since this syringe has projections provided on the rear surface of a flange of a syringe barrel, when it is inserted in an insertion groove of a cylinder holder, the tips of projections are compressed and the flange is fixed. Consequently, even when a solution having high viscosity is injected at higher pressure, breakage does not occur easily. Further, pressure-receiving area may also be increased by providing a guide defining mounting direction of a syringe, alternatively, a positioning mechanism may be provided so as to obtain mounting at a correct position, or the surface of a flange may be roughened.

Abstract: A medical syringe employs a capsule containing multiple doses of medication within a sealed storage chamber formed between concentric inner and outer walls. The inner wall forms a cavity including a delivery chamber from which a single dose of medication is ejected. The syringe includes an ejection port, an axial moveable plunger extending into the cavity and delivery chamber, and a body with a compartment that holds the capsule. With the plunger in a first position, the capsule is closed. With the plunger in a second position, the delivery chamber is filled with a single dose of medication. With the plunger in a third position, the single dose of medication is ejected from the delivery chamber though the injection port.

Abstract: Many of those having diabetes take a combination of slow and fast acting types of insulin. It is important that the different forms of medicament do not become confused and that the patient does not receive the incorrect medicament. In combination a medicament delivery apparatus and a medicament cartridge are provided, the medicament delivery apparatus including at least one switch and the medicament cartridge comprising a cartridge housing within which a medicament is provided, a displaceable piston located internally at one end of the housing and a raised ring of material about an external periphery of the medicament cartridge, the ring of material being of sufficient dimensions, in use, to trip the at least one switch of the medicament delivery apparatus.

Abstract: An end-of-content arrangement for preventing a dose setting member of an injection device to be set to a dose larger that the medicament remaining in the injection device. The arrangement is particular suitable for injection devices operating with non-equistant dose volumes. The arrangement comprises an indentation provided on the housing or on the dose setting and injection member which indentation arrest a stop member when less than one dose unit is left in the cartridge. The stop member is coupled to the dose setting member such that the interaction between the indentation and the stop member prevents a dose larger that the remaining medication in being set.

Abstract: A pressure sleeve assembly and a method of its use in a fluid injection system are disclosed. The pressure sleeve assembly includes a longitudinal base member, an endplate associated with the longitudinal base member, a fixed or freely removable door, a cylinder and a pivotal arm coupling the cylinder to the longitudinal base member. The pressure sleeve assembly includes properties that increase the ease of use and maintenance of the assembly so as to reduce the effort required by the user and increase the biosafety aspect of the assembly. In addition, the pressure sleeve assembly includes properties that reduce the amount of effort required by the physician prior to and during use of the system as well as properties that increase its range of applications.

Abstract: The auxiliary device (2) for protecting a needle (30) comprises: a protector support (20) which delimits a chamber (27) for receiving a reservoir (1) of fluid to be injected, which reservoir is provided with a piston (8) and which support (20) is provided with means (31) for being fixedly joined to the reservoir (1); a needle protector (22) which can be moved relative to the support (20) between a retracted position and a deployed position for protecting the needle (30). The support (20) comprises the needle (30) along the axis of the chamber (27). The joining means (31) comprise hooks (32) which protrude in the chamber (27) and which delimit, around the needle (30), a cage (31) for resiliently latching around the neck (10) of a carpule (1) which forms the reservoir.

Abstract: An injection device for injection of a medicament from a medicament cartridge 40 having a neck portion is disclosed. The injection device further comprises a main housing 4 in which the medicament cartridge 40 is releasably retained by first and second retaining means 92,94. The retaining means 92,94 are each moveable between a first position in which the neck portion is engaged thereby to retain the medicament cartridge 40 in the main housing 4 and a second position which allows the medicament cartridge 40 to be removed from the main housing 4.

Abstract: A needleless syringe that provides the necessary high pressure, is easily generated despite the utilization of relatively thin-walled glass ampules for storing an injectable medicine. A plastic body of the needleless syringe contains an interior space surrounded by walls. The interior space is divided into a first region with one end open to the outside and an adjoining second region. A glass ampule containing a medicine, which is sealed at both ends with plunger-type stoppers, is disposed in the first region. The second region contains an output opening leading through the wall of the plastic body. A ram is provided with which the stopper that is averted from the second region can be pushed into the glass ampule and into the second region.

Abstract: A device for injecting fluid from a pre-filled cartridge is provided. The device includes a needle for piercing a patient. After an injection, the needle can be retracted to prevent inadvertent contact with the contaminated needle. A needle retainer releasably retains the needle in the retracted position. The needle can subsequently be re-extended to administer a subsequent injection. After the cartridge is emptied, the cartridge can be removed, if desired, and replaced with another cartridge for additional injections. Alternatively, the needle can be retracted into the device and safely disposed of in a sharps container.

Abstract: A threaded syringe provides a mechanism by which a clinician can deliver a viscous fluid through a relatively small lumen and can obtain tactile or audible feedback of delivery. The threaded syringe allows for delivery of more viscous fluids with less force and/or allows for more controlled delivery. The syringe includes a syringe barrel and a sliding member positioned on the proximal end of the syringe barrel. The sliding member has a first threaded hole and a second hole. The sliding member is slidable on the syringe barrel between a first position at which the first threaded hole is aligned with the syringe barrel for precise delivery of a material from the syringe and a second position at which the second hole is aligned with the syringe barrel for filling of the syringe or to stop bleed out.

Abstract: Injection devices are known for the self administration of medicament by patients. The medicament is typically contained within a cartridge located within the injection device. It is a problem that injection devices should be small enough to fit into a jacket pocket or a hand bag without difficulty. Also, the injection device must be of a size that enables a piston or similar used to drive the Cartridge bung within the cartridge to be moved both to a maximum dispense position within the cartridge and to be fully withdrawn from the cartridge to allow for replacement of the cartridge. A drive mechanism for an injecting device is disclosed in which the drive mechanism comprises a displaceable dosing spindle 6, a dial dose means 8, a transmission means 10, and a cable means 12, a piston comprising a plurality of nested piston members 30, 32, 34, displacement of the transmission means 10 causing the cable means 12 to move at least one of one of the nested piston members to drive a cartridge bung 18.

Abstract: The invention relates to: A medication delivery device and a method of making such a device. The object of the present invention is to provide a handy medication delivery device that may be easily adjusted to the different needs of a given user in different situations and to the different needs of different users, and which is economic from a production point of view. The problem is solved in that it comprises a basis module (1) and one or more replaceable modules (2, 3, 4, 5, 6), each of which is adapted to cooperate mechanically and/or electronically with the basis module to provide a specific function, and the basis module includes resources that are jointly used by the replaceable modules. This has the advantage of providing a rational concept for economically supplying high quality, mass-produced devices capable of being customized to individual users' needs for functionality by avoiding the duplication of key components.

Abstract: A needle protection device for a vial, or capsule, has a housing hingedly or flexibly connected to a needle collar by a hinge. The collar has a main portion configured to fit about at least a portion of the body of the vial and an extension configured to fit about at least a portion of the neck of the vial. A needle hub, movable along the neck of the vial and to which a needle extends, is interposed between the body and neck of the vial. The hub has a skirt portion that could be moved along the neck of the vial for capping or overlapping the extension of the collar to thereby non-removably secure the collar to the vial. An improved syringe assembly is effected when a vial of the instant invention is placed within a vial holder applicator, such as for example a CARPUJET applicator.

Abstract: A person having diabetes will often be required to take both slow acting and fast acting forms of insulin. It is important to be able to distinguish readily between medicament cartridges containing different medicaments. The present invention enables a user to distinguish readily between medicament cartridges containing different medicaments. A medicament cartridge and adaptor top assembly is provided, the medicament cartridge comprising a cylinder having a bottleneck provided with a flange at a first end, a fluid impermeable membrane covering the first end, a cap beaded under the flange to retain the fluid impermeable membrane in place, and a piston displaceably located within a second end of the cylinder, and the adaptor top comprising a sleeve having a body portion and a tapered portion, the tapered portion being provided with a smaller diameter end, the smaller diameter end being located beneath the cap.

Abstract: A dual port syringe has an upper port for connection to a fluid reservoir and a lower port for delivery of the medical fluid under pressure to a patient. A first valve is connected between the fluid reservoir and the upper port, and second valve is connected between the lower port and the patient. During a fill operation, a piston is moved within the syringe to drawn fluid from the reservoir into the syringe through the upper port. During injection operation, the piston moves in an opposite direction to force fluid out of the syringe through the lower port.

Abstract: A safety needle apparatus having a needle is provided that includes a first cylinder extending from a proximal end to a distal end thereof and defining a longitudinal axis. The first cylinder further defines at least one longitudinal keyway in a side wall thereof and at least one keyslot disposed adjacent the distal end of the first cylinder. The keyslot is rotationally spaced apart from the at least one keyway relative to the longitudinal axis. The keyway includes a raised surface relative to and disposed adjacent the distal end of the first cylinder. A second cylinder is mounted for relative movement with the first cylinder and defines at least one radially projecting key adjacent a proximal end thereof.

Abstract: An injection device having an incremental clicking mechanism providing the user with an indication of the number of doses being set. For handling different types of medicaments having different dose volumes in the same type of injection device it is beneficial to provide an additional clicking mechanism which is easy changeable. The clicking mechanism is preferably a curved track provided between the dose setting member and a non-rotatable clicker element.

Abstract: A firing device has a housing (10, 20) for an injector (1) with a trigger (4) whose action to eject a dose from its needle (2) is forwards against a resistance. The housing contains a spring (24) which acts on an axially movable locator (23) for the injector (1) that co-operates with its trigger (4). The device is primed by compressing the spring (24), the injector then being latched in a rearward position. Release of the catch (28) causes the spring (24) first to propel the injector (1) forwards, acting through the locator (23) and trigger (4), until the needle (2) is projected, and then to overcome the resistance to the trigger (4) to actuate that and cause a dose to be ejected.

Abstract: An ampule having a body portion and a sealed end portion and a sealed delivery portion adapted for use in a delivery syringe system for controllably dispensing a low viscosity material, such as a liquid, gel, or paste. An ampule having sealed rear portions adapted to mate with a plunger of a syringe so as to facilitate controlled dispensing of a low viscosity material. The syringe has a breach positioned to provide controlled flow of the dispensed low viscosity material and facility easy removal from the syringe. Low viscosity materials, such as liquids and gels, are controllably dispensed in a measured unit dose quantity. The present invention has many applications, but is particularly applicable to dispensing low viscosity materials such as used in coatings and not injected parenterally, and is particularly applicable to dental applications.

Abstract: Syringes and methods of using are described which protect the syringe barrel cavity from contaminants. A first syringe is formed with a corrugated sheath which encloses the plunger and space between the rearward end face surface of the syringe barrel handle member and the forward face of the plunger handle member. A second syringe is formed with a syringe barrel having a straight segment and a corrugated segment having the forward face of the plunger handle member molded to the rearward terminus of the corrugated segment of the syringe barrel. A third syringe is formed from mating syringe barrel and plunger member walls. The walls of the mating syringe barrel and plunger member are concentric and slide relative to each other while maintaining an enclosure around the plunger shaft. A fourth syringe is formed from inner and outer concentric syringe barrel walls mating with the walls of a plunger member.

Abstract: The present invention has for its object to provide a vacuum sampling tube which is capable of preventing a pretreating reagent accommodated in the vacuum sampling tube from entering the blood vessel and the like even in the event of a backflow of a specimen, such as blood, during vacuum sampling, such as vacuum blood collecting, and a vacuum sampling method.

Abstract: A disposable aspirating syringe for dental medicine having the ability to accept single use or disposable drug cartridges. The syringe offers a retractable needle and a break-away plunger to facilitate disposal and increase safety.

Abstract: A therapeutic dispenser is provided that includes a housing and a carriage movably supported by the housing and including an engagement surface at a distal end thereof. A plunger is supported by the carriage and engageable with the housing to dispense a first therapeutic through the engagement surface. A second therapeutic is supported with the housing. The first therapeutic and the second therapeutic are individually dispensable from the housing. The housing may include a channel that guides movement of the carriage. The housing can include a handle and a cap. The cap is releasably engageable with the handle.

Abstract: An injection device comprising a housing and a dose setting mechanism including a dose setting element. Contrary to prior art injection devices, the dose setting element can only be set at a few different dose settings. This is established by forming the dose setting element as a rotatable dish concealed within the housing and having a number of projections projecting outside the boundaries of the housing through a slot in the housing. A dose is set by activating a projection which in addition provides the user with a tactile guidance. Usually one projection is provided for one dose setting limiting the number of doses to be set to the number of projections.

Abstract: A pen-style injector (20) includes an automated mover (70) that completes a combination of two substances such as a reconstitution process to reconstitute a lyophilized medicament prior to making an injection. The automated mover (70) is preloaded selectively released to automatically reconstitute the medicament at a controlled rate. The illustrated embodiment includes a mechanical spring (70) that provides the necessary movement of components within the injector (20) to complete the automated reconstitution process. The injector also has safety features (100) to prevent an injection prior to completing the automated combination of the substances.

Abstract: An applicator is provided for dispensing a first and a second component of a biological adhesive. The applicator includes a housing having a housing head for enclosing therein a first reservoir containing the first component, and a second reservoir containing the second component. The housing further includes an elongated body portion defining a longitudinal axis for enclosing therein a conduit assembly having a first and a second conduit in communication with the first and second reservoir, respectively. An activator assembly is provided which includes an activator and a rachet mechanism for compressing the reservoirs within the housing for dispensing the biological components into the conduits. An applicator tip having two separate channels in communication with the conduits may be provided on a distal end of the elongated body portion for dispensing the components on the application site. The first and second components are preferably fibrinogen and thrombin which intermix to form a fibrin sealant.

Abstract: A method for treating priapism in a mammal by administration of a botulinum toxin.

Abstract: The application describes a dispensing apparatus (1) for dispensing a unit dose of a pharmaceutical substance, in particular for intranasal administration. The nozzel unit (3) has a safety cap (48) thereon and the cap has legs (51) which can locate within the actuating device. Upon mounting of the nozzle unit on the actuating device, the legs on the safety cap push down a ram (8) in the device against the action of a spring (10), until the head (23) of the ram engages over a shoulder. The ram is released only by both depression of a button (34) on the device and by relative movement of two parts of the device. That relative movement is blocked by a wing (53) on the safety cap so that actuation cannot occur until after removal of the cap. Force on the button moves the two parts together and depresses the button, so that the ram is released and is forced by the spring to move a cylinder relative to a piston (71), thereby discharging the contents of the cylinder through the nozzle opening.

Abstract: A syringe, for injecting anesthetic contained in a medicine vial. The syringe includes a housing having a needle end and a plunger end, connected by a body; to which housing is attached a plunger assembly having a plunger at the plunger end. There is a vial slot in the housing, cooperatively sized for receiving a medicine vial. A needle assembly slot is in the body, at the needle end, for receiving a needle assembly from a side of the body. A seat at the needle end of the housing receives and locates a corresponding seat portion of the needle assembly within the housing. Depressing the plunger housingward impales the vial onto a penetrator of the needle assembly and seats the assembly firmly.

Abstract: An injection device is provided. The device includes a housing having a first end defining a first opening. A plunger is received within the first opening of the housing to move between first and second positions. A cartridge is disposed in the housing and has an interior serving as a reservoir for a drug. A delivery needle is disposed within the housing and is in fluid communication with the reservoir via an interruptible fluid channel. A locking mechanism is disposed in the housing. In the first position of the plunger the delivery needle is enclosed by the plunger and in the second position of the plunger the delivery needle is placed in an injection position and the plunger activates the locking mechanism whereby when the plunger returns to the first position the locking mechanism prevents the needle from being placed in the injection position.

Abstract: A medication delivery pen is provided having a lead screw with an enlarged portion at a first end thereof and an end longitudinally opposite the first end in contacting engagement with a plunger of a medication cartridge. The lead screw is selectively axially displaceable by a user when selectively administering a predetermined dosage amount of medication for injection into a patient. The medication delivery pen also includes a driver coaxially disposed about the lead screw; and, a reset ring non-rotatably disposed on the driver and axially slidable thereon and therealong. The reset ring is axially movable with respect to the driver when a dosage amount is set by a user of the medication delivery pen. The reset ring engages the enlarged portion of the lead screw upon a predetermined extent of relative axial movement between the reset ring and the lead screw.

Abstract: A device for injecting fluid from a pre-filled cartridge is provided. The device includes a needle for piercing a patient. After an injection, the needle can be retracted to prevent inadvertent contact with the contaminated needle. A needle retainer releasably retains the needle in the retracted position. The needle can subsequently be re-extended to administer a subsequent injection. After the cartridge is emptied, the cartridge can be removed, if desired, and replaced with another cartridge for additional injections. Alternatively, the needle can be substantially permanently retracted into the device and safely disposed of in a sharps container.

Abstract: An intradermal delivery device for use in intradermally injecting substances into the skin of an animal includes a needle cannula supported by a hub portion that is attachable to a prefillable container. A limiter portion surrounds the needle cannula and extends away from the hub portion toward a forward tip of the needle cannula. The limiter portion includes a skin engaging surface extending in a plane generally perpendicular to an axis of the needle cannula. The skin engaging surface is received against skin of an animal to administer an intradermal injection. The forward tip extends beyond the skin engaging surface a distance that enables penetration of the needle cannula into the dermis layer of the skin of the animal enabling injection of the substance into the dermis layer of the animal. The device includes enclosure means that is moveable for concealing the needle cannula after the injection has been administered.

Abstract: The present invention includes a method for evaluating the acceptability of a device for the delivery of cells in a cell implantation therapy comprising: determining a first rate of cell survival in a stable environment, evaluating a second rate of survival during a procedure using a device that manipulates cells, and comparing the first and second rates of survival to determine the effect of the device used during the procedure on cell survival rates to establish a base line effect of the manipulative procedure on cell survivability. That method may be practiced wherein after determining the second survival rate, modifying the design of the device, evaluating a third rate of survival after modifying the design of the device to determine if the change has increased the rate of survival during the procedure. The method is particularly effective where the procedure is selected from the group consisting of cell harvesting, cell transport, cell implantation, and cell delivery.

Abstract: A dual port syringe has an upper port for connection to a fluid reservoir and a lower port for delivery of the medical fluid under pressure to a patient. A first valve is connected between the fluid reservoir and the upper port, and second valve is connected between the lower port and the patient. During a fill operation, a piston is moved within the syringe to drawn fluid from the reservoir into the syringe through the upper port. During injection operation, the piston moves in an opposite direction to force fluid out of the syringe through the lower port.

Abstract: A method for lubricating a sealing member and a medicament chamber in a drug delivery device includes providing lubricating silicone on the surface of the stopper and within the plastic material of the chamber. The stopper preferably is first washed and rinsed in hot deionized water followed by drying. The dried sealing member is then tumbled with polymeric silicone and then irradiated at a target dose between 2.5 to 4.0 Mrads to cause the silicone molecules to bond with the elastomeric material of the stopper. The irradiated sealing members are then loaded in any of a series of chambers including syringes, pre-filled syringes, drug cartridges, and needleless injector ampules. The chamber preferably is made from a plastic material that has been mixed with a lubricating solution such as silicone when the plastic is compounded.

Abstract: Since this syringe has projections provided on the rear surface of a flange of a syringe barrel, when it is inserted in an insertion groove of a cylinder holder, the tips of projections are compressed and the flange is fixed. Consequently, even when a solution having high viscosity is injected at higher pressure, breakage does not occur easily. Further, pressure-receiving area may also be increased by providing a guide defining mounting direction of a syringe, alternatively, a positioning mechanism may be provided so as to obtain mounting at a correct position, or the surface of a flange may be roughened.

Abstract: Since this syringe has projections provided on the rear surface of a flange of a syringe barrel, when it is inserted in an insertion groove of a cylinder holder, the tips of projections are compressed and the flange is fixed. Consequently, even when a solution having high viscosity is injected at higher pressure, breakage does not occur easily. Further, pressure-receiving area may also be increased by providing a guide defining mounting direction of a syringe, alternatively, a positioning mechanism may be provided so as to obtain mounting at a correct position, or the surface of a flange may be roughened.