Abstract: The present invention is directed to an automatic reconstitution drug delivery device. The inventive device effects simple and automatic reconstitution of a dry drug. To effect reconstitution, a user displaces a release button which causes first and second chambers of a drug cartridge to communicate, resulting in automatic mixing of a diluent and dry drug to effect reconstitution of the dry drug. The user then simply sets the dose volume using a dose-setting mechanism, and administers the injection in a manner typical of self-injection drug delivery devices. Whole or partial automatic priming can be also achieved by the device.

Abstract: A drug delivery system includes an automatic injector that can deliver a small, precise amount of a therapeutic agent. The automatic injector includes a chamber for containing a liquid component and a thin porous member that carries thereon and/or therein the small, precise amount of therapeutic agent. Upon activation of the automatic injector, a flow path opens from the chamber through the porous member, enabling the liquid component to rapidly mix with the therapeutic agent before being injected.

Abstract: A syringe device having a syringe barrel and a syringe piston having a container housing. At least a portion of the container housing is insertable within an internal chamber of the syringe barrel. A fluid passageway extends from the container housing through a piston stem. A method of protecting a syringe handler including providing the components of a syringe device and encasing the components in a protective film. The protective film is loose to allow manipulation of the syringe components relative to one another without opening or puncturing the film. Protective syringe device packaging that includes a laminate film of material sealed to encase the components of a syringe device containing a potentially harmful agent.

Abstract: An injection device including a drive unit, a delivery unit, a dosing unit, a trigger for triggering an injection, a first coupling mechanism between the drive unit and the delivery unit, and a second coupling mechanism between the dosing unit and the drive unit, wherein the drive unit is tensioned by a rotation of the dosing unit and when the drive unit is tensioned the first coupling mechanism is disengaged and the second coupling mechanism is engaged, and wherein when an injection is triggered first the first coupling mechanism is engaged and then the second coupling mechanism is disengaged. In some embodiments, the device may include a third coupling mechanism which only releases the delivery unit after the engagement and disengagement which follow a triggering.

Abstract: A medical syringe apparatus includes a syringe unit, a hypodermic needle attached to the syringe unit and at least one interfacing member for mating a labeled medication container to the syringe unit. The medication label is visible. The container remains mated to the syringe when the syringe is in use. Risk of mislabeling the syringe may therefore be substantially reduced or eliminated and patient safety may accordingly be improved.

Abstract: A G-CSF solution formulation which is substantially free from proteins as a stabilizer but which contains at least one amino acid or a salt thereof as a stabilizer.

Abstract: The present invention relates to a method for ensuring a constant target speed of a battery driven electrical motor, the battery driven electrical motor being adapted to move a piston rod in an injection device so as to inject a set dose of medicine from the injection device, the method comprising the steps of setting a first target speed to be reached by the motor, determining whether the first target speed can be reached, and, if the first target speed can be reached, maintaining the first target speed until a set dose of medicine has been injected from the injection device, or if the first target speed cannot been reached, setting a second target speed.

Abstract: A trigger operated syringe (100) for intramammary injection of antibiotics has a fluid containing syringe cartridge (203) activated by a plunger (206) which is inserted into the syringe cartridge (203A) and expels fluid when the trigger (205) is pulled. A syringe cartridge holding mechanism (223) holds the syringe cartridge in place until the trigger (205) is released and the plunger (206) retracted. Single syringe cartridge (203) and multiple syringe cartridge (204) versions are disclosed. The plunger moves in a direction which is effectively perpendicular to the direction of movement of the trigger, allowing for ease of injection to a cow's teats, and ejection of the spent cartridges.

Abstract: A device for administering a fluid product including a housing, a conveying device for the product, a coupling element provided for the drive of the conveying device and which can be rotated about a rotational axis, a first blocking element connected in a rotationally secure manner to the coupling element, a second blocking element detachably engageable with the first blocking element thereby preventing a rotational movement thereof in the drive direction and enabling said rotational movement to take place in the counter dosing direction, a torsion spring connected to the coupling element such that it is stressed by the rotational movement when the blocking elements are engaged in a blocked position and drives the coupling element in a rotary manner after the blocking position is released, and a release element coupled to at least one of the blocking elements such that a release movement of the release element displaces at least one of the blocking elements from the blocked position, the release element also

Abstract: Ampoule unit for an administering device, comprising an ampoule having a distal end with an opening for dispensing a product and a proximal end with an opening for accommodating a displacement body unit, and the proximal end of the ampoule has a thread which can be placed in a thread engagement with a complementary thread which is part of the displacement unit or a displacement body unit.

Abstract: A reloadable medicine injector and methods are described in which a barrel with a receiving cavity is adapted to slidably receive a syringe subassembly for axial movement therein. Upon removal of a safety and release of a syringe driver, the syringe driver moves forward and injects the syringe needle. A plurality of penetration controls are shown for controlling injection needle penetration depth. The penetration controls have an abutment and various lengths to provide different needle penetration depth positions. In one form of penetration control a sleeve is used against which the syringe or related parts contact. In another form the front return spring is used as a penetration control. A cushioning ring may be used to reduce syringe breakage. A load distribution and guide ring may be used to distribute loading applied to the syringe and help guide the moving syringe.

Abstract: A delivery device includes a durable housing portion and a separable disposable portion that selectively engage and disengage from each other. The disposable housing portion secures to the patient-user and may be disposed of after it has been in use for a prescribed period. Components that normally come into contact with a patient-user or with infusion medium are supported by the disposable housing portion, while the durable housing portion supports other components such as electronics and a drive device. A reservoir is supported by the disposable housing portion and has a moveable plunger that operatively couples to the drive device, when the disposable and durable housing portions are engaged.

Abstract: An injection device is provided. The device includes a housing having a first end defining a first opening. A plunger is received within the first opening of the housing to move between first and second positions. A cartridge is disposed in the housing and has an interior serving as a reservoir for a drug. A delivery needle is disposed within the housing and is in fluid communication with the reservoir via an interruptible fluid channel. A locking mechanism is disposed in the housing. In the first position of the plunger the delivery needle is enclosed by the plunger and in the second position of the plunger the delivery needle is placed in an injection position and the plunger activates the locking mechanism whereby when the plunger returns to the first position the locking mechanism prevents the needle from being placed in the injection position.

Abstract: A chemical liquid injection system which a piston driving mechanism is driven only when a cylinder holding mechanism appropriately holds liquid syringes of various sizes through a cylinder adapter and such manner. When the liquid syringe 200S of a size other than the maximum size is appropriately held by the cylinder holding mechanism 120, RFID chip 230 is located on the side at the rear of metallic cylinder holding mechanism 120. A pair of resonance antennas are disposed on the left and right of the RFID chip, and an RFID reader 131 is disposed below the resonance antennas. When the liquid syringe 200S is appropriately held by the cylinder holding mechanism 120, RFID chip 230 wirelessly communicates with RFID reader 131 favorably, and the piston driving mechanism can be operated only in this state.

Abstract: Since this syringe has projections provided on the rear surface of a flange of a syringe barrel, when it is inserted in an insertion groove of a cylinder holder, the tips of projections are compressed and the flange is fixed. Consequently, even when a solution having high viscosity is injected at higher pressure, breakage does not occur easily. Further, pressure-receiving area may also be increased by providing a guide defining mounting direction of a syringe, alternatively, a positioning mechanism may be provided so as to obtain mounting at a correct position, or the surface of a flange may be roughened.

Abstract: A number of surgical devices for the mixing and dispensement of a dual component surgical adhesive onto tissue are described. The surgical devices can provide adhesive storage chambers for the adhesive components within the surgical device and can have removable cartridges that draw and mix and apply the adhesive onto tissue. The removable cartridges can be easily replaced when clogged with set adhesive. Alternately, an adhesive dispensing device can comprise an adhesive dispensing gun containing the dual components of the adhesive and a plurality of rotatable orifices that can dispense the adhesive. One orifice can be selected and aligned with the adhesive dispensing gun to mix and apply the adhesive onto tissue. A fresh orifice can be rotated into alignment with the gun should a prior orifice become blocked.

Abstract: A drug delivery system is disclosed which may be a throwaway or reusable device for delivery at least one drug to a patient. Also described is a method for administering a drug using said device and a packaged drug for use with said device. The drug delivery device (10) comprises a housing (12), a means (14) for generating a force capable of pushing a drug (16) from a packaging (18) into a human or animal body, a means (20) for transmitting said force to push the drug (16) from the packaging (18) into the human and animal body, and a means (38, 42b) for triggering the device. Where the device is a single use drug delivery system, a packaged drug (100) forms an integral part of the device. The packaged drug comprises a region (102) allowing it to be slidably mounted to the drug delivery device (10).

Abstract: A method and device for intradermal delivery of a reconstituted powdered medicament. The device includes a chamber, which is in fluid communication with a microdevice, e.g. microabrader or one or more microneedles. A cartridge containing the powdered medicament may be located within said chamber. At least one burstable membrane retains a powdered medicament within the housing. The method involves the steps of positioning the device at a delivery site on the skin of a patient and intradermally administering the medicament by dispensing a diluent from a diluent source an through inlet port to rupture the membranes, reconstitute the powdered medicament and deliver the reconstituted medicament through the microdevice to the dermal region of the skin.

Abstract: Since this syringe has projections provided on the rear surface of a flange of a syringe barrel, when it is inserted in an insertion groove of a cylinder holder, the tips of projections are compressed and the flange is fixed. Consequently, even when a solution having high viscosity is injected at higher pressure, breakage does not occur easily. Further, pressure-receiving area may also be increased by providing a guide defining mounting direction of a syringe, alternatively, a positioning mechanism may be provided so as to obtain mounting at a correct position, or the surface of a flange may be roughened.

Abstract: A carpule and its method of manufacture, the carpule tubular body composed of a polypropylene or similar polymer, the tubular body being sealed at one end by a seal of a thermoplastic vulcanizate (TPV) or similar polymer, the seal having been injection molded in contact with the tubular body prior to full curing of the material composing the tubular body, such that a chemical fusion bond is created between the seal and the tubular body.

Abstract: A medication delivery system includes an array of cartridge-receiving ports, a medication receiving fluid conduit, and a plurality of dispensing elements. Each port includes a fluid channel terminating at a fluid outlet and is configured to receive one of a plurality of cartridges that each contain a bolus volume of medication. The medication-receiving fluid conduit is fluidically coupled to the fluid outlet of each cartridge-receiving port at a first region and to a system outlet conduit at a second region (which in turn can be coupled to a patient catheter line). Each dispensing element corresponds to a single cartridge-receiving port so that, upon activation of the dispensing element, at least a portion of the bolus volume of medication flows through the fluid outlet of each cartridge-receiving port into the medication-receiving fluid conduit. Related apparatus, systems, and methods are also disclosed.

Abstract: A combination of a disposable, wearable, self-contained medicine dispensing device, a cylindrical medicine container 52 incorporating a piston and having an open distal end and a proximal end closed by a closure body 54 made of a material, preferably silicone, that can be perforated by a needle, and a catheter device 16 having adhesive means 26 for attaching the catheter device to the skin of a user of the combination, the dispensing device comprising a housing 34, 36 having a compartment for receiving the container and further a not shown piston rod for displacing the piston towards the closed proximal end and actuating means for displacing the piston rod, the catheter device comprising a sealing ring 56?for receiving the closure body, and the dispensing device and the catheter device comprising co-operating attachment means for attaching the dispensing device to the catheter device with the container received in the compartment with the piston rod abutting the piston and the closure body received in the sea

Abstract: An administering apparatus for administering a fluid product, including a casing, a reservoir for the product, a driven device which acts on the product contained in the reservoir to deliver the product, and a drive device which acts on the driven device and performs a delivery stroke in a drive direction from a delivery position up to a delivery stopper to deliver a product dosage to be administered, wherein a priming stopper is provided for the drive device and limits a priming stroke of the drive device, which serves to bleed, in the drive direction, wherein the priming stroke is axially shorter than a maximum delivery stroke, and wherein the drive device can be moved in the drive direction from a priming position up to the priming stopper and transversely to the drive direction as far as the delivery position.

Abstract: A delivery device includes a durable housing portion and a separable disposable portion that selectively engage and disengage from each other. The disposable housing portion secures to the patient-user and may be disposed of after it has been in use for a prescribed period. Components that normally come into contact with a patient-user or with infusion medium are supported by the disposable housing portion, while the durable housing portion supports other components such as electronics and a drive device. A reservoir is supported by the disposable housing portion and has a moveable plunger that operatively couples to the drive device, when the disposable and durable housing portions are engaged.

Abstract: A medicament container, medicament dispensing kit and packaging process that minimizes exposure of the medication to oxygen to prevent degradation of the medication are disclosed.

Abstract: Some embodiments of a medical infusion pump system include a pump device and a removable controller device. When the pump device and the removable controller device are removably attached to one another, the components may provide a portable infusion pump unit to dispense medicine to a user. In particular embodiments, the removable controller device includes a user interface to readily provide information, for example, about the operation of the pump.

Abstract: A medical delivery system comprising a container and a dosing assembly where the container is fastenable to the dosing assembly. When the container is secured to the dosing assembly, a recognition feature on the container is adapted to co-operate with a variable resistor disposed in the dosing assembly to thereby facilitate an identification of the specific type of container which is secured to the dosing assembly. Furthermore, the present invention relates to a container and a dosing assembly suitable for use in the medical delivery system according to the present invention.

Abstract: Since this syringe has projections provided on the rear surface of a flange of a syringe barrel, when it is inserted in an insertion groove of a cylinder holder, the tips of projections are compressed and the flange is fixed. Consequently, even when a solution having high viscosity is injected at higher pressure, breakage does not occur easily. Further, pressure-receiving area may also be increased by providing a guide defining mounting direction of a syringe, alternatively, a positioning mechanism may be provided so as to obtain mounting at a correct position, or the surface of a flange may be roughened.

Abstract: The invention relates to a system for injecting a fluid through or into the human skin, optionally by needle-free injection or by injection with a needle, with (i) an injection device (110) which includes an ampoule (112) with an ampoule body (114) forming a chamber for receiving the fluid to be injected; an ampoule piston (118) which is axially movable and sealingly guided in the chamber; an outlet (124) disposed at the distant end of the ampoule (112) for the fluid to be injected, wherein the ampoule (112) is rounded in the region of the outlet (124) and the rounded region forms a skin contact surface (126) for the needle-less injection through or into the human skin; and at least one first coupling element (128) of a coupling device which is arranged at the distal end of the ampoule (112) on the ampoule body (114) and configured for sealingly and reversibly attaching a needle attachment (150), and (ii) a needle attachment (150) with a cannula part (152) comprising a needle (156); and an adapter part

Abstract: A medical delivery system (100) having a container (102) and a dosing assembly (104), and wherein one of the container and the dosing assembly comprises a rotatable element (106) adapted to engage the other one of the container and the dosing assembly. A container suitable for use in said medical delivery system. A dosing assembly suitable for use in said medical delivery system.

Abstract: A product dispensing apparatus including a reservoir module, a dosing module and a dose setting member. The reservoir module includes a front casing section, a block, a first connector, a piston, and a piston rod moveable in a dispensing movement and against the dispensing movement, and including a return block engageable with the block, wherein engagement between the block and the return block prevents the piston rod from moving against the dispensing movement. The dosing module includes a rear casing section, including a second connector which is engageable with the first connector to form a detachable connection between the reservoir module and the dosing module, and a dosing and drive device. The dose setting member engages the piston rod such that it is moveable together with and in the same direction as the piston rod during the dispensing movement and is moveable relative to the piston rod against the dispensing movement.

Abstract: A method of administering liquid medicine such as epinephrine to a patient includes administering a first dose followed by administering an optional second dose is described herein. Also described herein are devices useful for carrying out the methods described and kits containing these devices.

Abstract: An ampoule for use with an administering device such as an injection or infusion apparatus, at least two recognition elements associated with the ampoule, each of which at least two recognition elements can be arranged in one of at least two predetermined positions relative to the ampoule, wherein the at least two predetermined positions are asymmetrically located relative to the ampoule, and an administering device such as an injection or infusion apparatus which can be coupled to the ampoule. In one embodiment, the administering device has at least two associated sensors at predetermined positions in order to recognize the arrangement of the at least two recognition elements associated with an ampoule and, in another embodiment, the administering device has at least one sensor which can be moved relative to an ampoule.

Abstract: An injection device including a housing and a delivery element guided in a liquid-tight manner in relation to the housing, the delivery element having a substantially smooth, cylindrical outer wall region and surrounded by at least one annular sealing element.

Abstract: An injection device having a delivery element with an inner thread may be driven by rotation and includes a cylindrical outer wall region, which is substantially smooth. Such features provide a delivery element configured such that it is less intimidating to patients than known threaded rods, and may facilitate easy cleaning. The delivery element may be non-rotatably guided and axially spring-loaded, and may be inserted axially into the housing when the reservoir is replaced. The driving thread element for the delivery element may be mounted in the vicinity of the distal end of the housing.

Abstract: An injector device for a pharmaceutical cartridge. The injector device includes a body defining a space for receiving a pharmaceutical cartridge. One or more retention members are disposed on the outer surface of the body. The injector device further includes a plunger rod having a connection member constructed for connection to a piston associated with a cartridge. The plunger rod has one or more receiving members. constructed to cooperatively retain the plunger rod on the body in a first position, and to release the plunger rod from the body when the plunger rod is moved to a second position. The plunger rod further includes a surface for engaging a pharmaceutical cartridge positioned within the body of said injector and for moving a pharmaceutical cartridge distally as the plunger rod is moved from its first position to its second position. A tamper evident band is secured to plunger rod and injector body.

Abstract: Fluid injector systems used for a variety of imaging and injection procedures are disclosed. The systems may include separate modules or assemblies that may be located in different rooms of a hospital or imaging facility. Various single use and multiple use components may also be used with the modules or assemblies of the system. In addition, the injector system may include hydraulic and/or pneumatic fluid sources to power the system modules of the present invention.

Abstract: An injector device for a pharmaceutical cartridge. The injector device includes a body defining a space for receiving a pharmaceutical cartridge. One or more retention members are disposed on an outer surface of the body. The injector device further includes a plunger rod having a connection member constructed for connection to a piston associated with a cartridge. The plunger rod has one or more receiving members constructed to cooperatively retain the plunger rod on the body in a first position, and to release the plunger rod from the body when the plunger rod is moved to a second position. The plunger rod further includes a surface for engaging a pharmaceutical cartridge positioned within the body of said injector and for moving a pharmaceutical cartridge distally as the plunger rod is moved from its first position to its second position, thereby activating the cartridge.

Abstract: A syringe for use with a carpule and needle is provided. The syringe comprises: (i) a holder for accepting the carpule, the holder comprising at least two linearly disposed first mating members; (ii) a plunger for engagement with the holder; and (iii) a shell for slidably housing the holder, the shell having a distal aperture and a proximal aperture, with a bore therebetween, the shell comprising at least one integral biased member proximate to the proximal aperture, the biased member having a second mating member proximate to a distal end, for mating with the first mating member, such that in a first position, the needle is housed within the shell and in a second position, the needle extends at least partially from the shell.

Abstract: An injector for injecting fluid from a syringe mounted thereon includes a housing, a drive member at least partially disposed within the housing and operable to engage a plunger of the syringe, and a syringe retaining mechanism associated with the housing. The syringe retaining mechanism is adapted to releasably engage the syringe regardless of the orientation of the syringe with respect to the injector. Further, the retaining mechanism is preferably movable upon rotation of the syringe between a relaxed state, where the syringe is engaged by the retaining mechanism, and a tensioned state, where the syringe is released from the retaining mechanism.

Abstract: The present invention provides an injection device that includes: a syringe 2 including a barrel 21 including a cylindrical barrel body 21a and a nozzle 21b provided at a front end of the barrel body so as to be communicated with the barrel body, a gasket 23 slidable in the barrel, and a plunger 24 connected with the gasket and capable of being placed into and removed from the barrel through a rear end opening of the barrel; a finger flange 25 provided in the vicinity of the rear end portion of the barrel body and molded integrally with or separately from the barrel body; a holder 3 having an inner diameter that allows the barrel to be inserted in a bore of the holder, attached to the barrel, and including a spiral protrusion 31a formed on the inner surface of a portion of the holder disposed around the nozzle; and an engagement structure capable of keeping a state in which the holder is attached to the barrel and releasing the attachment.

Abstract: The present invention discloses a medicament cartridge for an injection device, such as a syringe or a jet injector. The medicament cartridge according to the present invention includes a tube having a lumen, a needle operatively associated with an end of the tube and having a piercing end extending into the lumen, a second stopper located within the lumen near the other end of the tube and moveable within the lumen, and a first stopper located within the lumen, covering the piercing end of the needle, and moveable within the lumen. Firing the injection device to commence an injection may move the second stopper toward the needle, which compresses medicament located in the lumen between the first stopper and the second stopper. The compression of the medicament moves the first stopper into contact with the piercing end of the needle so that the piercing end pierces the first stopper to thereby create a fluid pathway for the medicament through the needle.

Abstract: The present invention provides a syringe device including a needle, a syringe body, and a syringe adaptor between the needle and the syringe body. This syringe adaptor includes a reservoir and a plunger configured to move into and out of the reservoir in a direction perpendicular to the longitudinal direction of the needle. The position and direction of travel of the plunger in the syringe adaptor allows a user of the syringe of the present invention to safely and accurately operate the syringe with one hand.

Abstract: A device for injecting fluid from a pre-filled cartridge is provided. The device includes a needle for piercing a patient. After an injection, the needle can be retracted to prevent inadvertent contact with the contaminated needle. A needle retainer releasably retains the needle in the retracted position. The needle can subsequently be re-extended to administer a subsequent injection. After the cartridge is emptied, the cartridge can be removed, if desired, and replaced with another cartridge for additional injections. Alternatively, the needle can be substantially permanently retracted into the device and safely disposed of in a sharps container.

Abstract: An administering apparatus for delivering a dosage of product including a casing with a reservoir for the product, a piston within the reservoir to deliver the product, a piston rod for engaging the piston, a drive device for driving the piston rod, and a dosage setting member mechanically engaging the piston rod and a stopper for the dosage setting member. The casing includes a front casing section containing a reservoir for the product and a rear casing section detachably connected to the front casing section. The front casing section is connected to or forms a first latching element, and the rear casing section is connected to or forms a second latching element. The latching elements are in latching engagement when the casing sections are connected. The casing sections may be axially fixed to one another by the latching engagement.

Abstract: The present embodiments provide for a syringe cartridge system that can be used in combination with multiple couplings and injection systems. The syringe cartridge system can be provided in a vacuum packaging assembly configuration. Alternatively, the syringe cartridge system can be provided with a coupler attached to a safety device, a hypodermic needle, or a Luer adaptor. The syringe cartridge system can also be used in combination with an automatic injector.

Abstract: A transfer assembly for transfering a fluid to a vial, admixing the same and then returning the fluid to a cartridge, the transfer assembly having a vial gripper located at a first end and a cartridge holder at the second end of an elongated outer housing, a fluid passageway extending between the vial gripper and the cartridge holder with piercing elements being located at respective ends of the fluid passageway. In a preferred embodiment, an adaptor is mounted on the end of the outer housing where the cartridge holder is situated. The adaptor may move from a retracted to an extended position wherein it will surround the needle.

Abstract: The present invention relates to management of information relating to medical fluids, containers therefor, and medical fluid administration devices for administering such medical fluids to patients. Data tags (e.g., RFID tags) are generally associated with containers of the invention and may be electromagnetically read from and/or written to using an electromagnetic device, for example, that may be associated with a medical fluid administration device of the invention.

Abstract: Since this syringe has projections provided on the rear surface of a flange of a syringe barrel, when it is inserted in an insertion groove of a cylinder holder, the tips of projections are compressed and the flange is fixed. Consequently, even when a solution having high viscosity is injected at higher pressure, breakage does not occur easily. Further, pressure-receiving area may also be increased by providing a guide defining mounting direction of a syringe, alternatively, a positioning mechanism may be provided so as to obtain mounting at a correct position, or the surface of a flange may be roughened.

Abstract: A fluid transfer device including a cartridge having a plurality of needles, an advancer operative to selectably advance any of the plurality of needles in the cartridge to a needle deployment position, and a syringe operative to convey fluid through the needle in the needle deployment position.