Abstract: The present invention is directed to a pulsatile ophthalmic peri-corneal drug delivery device. The device includes an annular body and a mechanism for releasing multiple separate and distinct doses of a therapeutic composition over an extended period of time.

Abstract: Wound treatment dressings comprising combinations of at least one conductive layer, at least one absorbent layer or a moisture regulation layer, and methods of making and methods of use are disclosed for treatment of wounds in humans and animals. The novel dressings aid in healing by helping restore the transepithelial potential of the skin, providing a functional anti-microbial barrier, and allowing for regulation of the moisture content of the wound without disturbing the wound.

Abstract: A surgical technique and device wherein an indwelling tube is placed in the eye of a patient having glaucoma. The tube diverts aqueous humor from the anterior chamber to the suprachoroidal space from which it is removed by blood flowing in the choroidal and uveal tissues. This decreases the intraocular pressure.

Abstract: The composite wound dressing apparatus promotes healing of a wound via the use of a vacuum pump. The vacuum pump applies a vacuum pressure to the wound to effectively draw wound fluid or exudate away from the wound bed. The vacuum pump is tethered to the wound dressing and is portable, preferably, carried by the patient in a support bag, which permits patient mobility. Moreover, the patient does not need to be constrained for any period of time while exudate is being removed from the wound.

Abstract: A method and apparatus for separation, concentration, and/or applying a biological or bio-engineered fluid. Generally, the fluid application device includes a sprayer body to enable the application of the fluid and a container adaptable to enable the separation of the fluid into at least a first component and a second component. The container is releasably coupled to the nozzle. The nozzle is adapted to withdraw at least one of the first component or the second component from the container after the fluid has been separated to apply the fluid to a selected site.

Abstract: A therapeutic device includes a fluid mover for one of raising, compressing, or transferring fluid, a therapeutic member operably connected to the fluid mover and actuated thereby, the therapeutic member operably disposably used on a patient in a manner to deliver therapy to the patient as function of actuation of the fluid mover, a controller operably associated with the fluid mover for controlling operation thereof, and a leak, blockage, temperature, voltage or current sensor operably connected to the fluid mover and the controller and to sense a leak, blockage, temperature, voltage or current in the device and send a signal to the controller whereby the controller controls the fluid mover as a function of the sensed signal.

Abstract: A dressing system is disclosed which has a sponge and a near infrared spectroscopy sensor positioned adjacent to the sponge for monitoring oxygenation levels of tissue adjacent to the sponge. The dressing system may further include a tube coupled to the sponge for removing fluid from the sponge. The dressing system comprises: a sponge; and a tensioning system coupled to the sponge. The tensioning system further comprises a central longitudinal member coupled to the sponge; and at least one tensioning member coupled to the central longitudinal member. A sequential compression system comprises: an envelope sleeve dressing; and a bladder that is both expandable and retractable. A tissue filler system is also described and includes a plurality of tubes; wherein each of the plurality of tubes further comprises apertures; and a pump coupled to at least one of the tubes which obviates the need for any sponge or wound screen.

Abstract: A contact lens product, a method and system for forming the contact lens product, and a method of using the contact lens product. The contact lens product includes a soft disposable contact lens loaded with a drug and the carriers which carry the drug. The lens has a mechanical and optical structure formed by the core polymer included within the lens. The contact lens product is configured to have the drug released from its carrier continuously into an eye of a mammal while the contact lens product is adhered to the eye of the mammal during a continuous period of time, the drug being configured to treat or prevent at least one adverse condition of the eye of the mammal during the continuous period of time. The mammal may be a human being or a veterinary animal.

Abstract: A reduced pressure delivery system is provided and includes a primary manifold, a blockage prevention member, and first and second conduits in fluid communication with the primary manifold. The primary manifold includes a wall surrounding a primary flow passage and is adapted to be placed in proximity to a tissue site. The blockage prevention member is positioned within the primary flow passage. A plurality of apertures is disposed in the wall to communicate with the primary flow passage. The first conduit is fluidly connected to the primary flow passage to deliver reduced pressure through the primary flow passage and the plurality of apertures. The second conduit includes an outlet proximate the primary flow passage or an outlet of the first conduit to purge the primary flow passage or first conduit to prevent blockages.

Abstract: A surgical tissue therapy device includes a sealant layer and a collection chamber. The sealant layer functions so as to create a sealed enclosure or space between it and the surface of a patient by forming, preferably, an airtight seal around a surgical area of skin trauma. The closed incision tissue therapy device also comprises a collection chamber, which may comprise an elongate tubular chamber with a plurality of longitudinally spaced openings. The collection chamber may be configured to be in fluid communication with the sealant layer and the area of skin trauma and functions as to distribute the negative pressure applied to a surgically closed area of skin trauma. Preferably, the pressure under the sealant layer is reduced by expanding the volume of the enclosure space and thereby decreasing the density of air molecules under the sealant layer.

Abstract: A convenient and hygienic skin therapy system comprising an encaser, one or more therapeutic compositions, a sealing means and optional accessories is disclosed. A method of using such a skin therapy system is also provided. The skin therapy system and the use thereof provides an effective, efficient and safe therapeutic approach.

Abstract: A personal feminine hygiene device includes a curvilinear frame. The curvilinear frame can include a plurality of disk members disposed around and extending from the curvilinear frame, wherein the larger diameter or radius disks can be disposed around an approximate midpoint of the curvilinear frame, and wherein the diameter or radius of the disks gradually decreases moving from the midpoint to the terminal ends of the curvilinear frame. The device can further include a bowl-shaped member extending from one end of the curvilinear frame and can include a series of slats formed therein. The bowl-shaped member can further include a cap at its anterior end terminating at a convex shaped tip especially configured to access the crease adjacent to the cervix where debris, e.g., mucous, tends to pool, while the slats and the disks assist in removing and containing debris from the vaginal and cervical walls.

Abstract: A surgical tissue therapy device includes a sealant layer and a collection chamber. The sealant layer functions so as to create a sealed enclosure, or space between it and the surface of a patient, by forming an airtight seal around a surgical area of skin trauma. The closed incision tissue therapy device also comprises a collection chamber, which may comprise an elongate tubular chamber with a plurality of longitudinally spaced openings. The collection chamber may be configured to be in fluid communication with the sealant layer and the area of skin trauma and functions as to distribute the negative pressure applied to a surgically closed area of skin trauma. Preferably, the pressure under the sealant layer is reduced by expanding the volume of the enclosure space and thereby decreasing the density of air molecules under the sealant layer. The collection material may comprise a material and/or a configuration that permits length changes based upon the length of the corresponding surgical wound or incision.

Abstract: A unitary biodegradable, absorbent flexible back and body strap for selectively applying a protective substance and a skin-protective agent to a user's body, the strap having an elongated thin parallelepiped midportion, a biconcave first gripping end, and an opposite biconcave second gripping end, each end having a tip narrower in width than the midportion. The midportion is impregnated with a protective substance, which may be a body lotion, sunscreen, insect repellant, or a combination of sunscreen and insect repellant. At least one protective agent layer may be disposed on a midportion top side, which contains a skin-protective agent. The user alternatingly pulls the first gripping end and the second end from side to side across the desired body portion to selectively apply the protective substance and the skin-protective agent discards the strap whereinafter the strap biodegrades.

Abstract: A portable device for mixing a dilute disinfectant solution comprising a first reservoir comprising a predetermined amount of said disinfectant solution, a chamber which is connected to said first reservoir and which holds a predetermined amount of dilutant, and means for discharging said predetermined amount of said disinfectant solution from said first reservoir into said chamber to be mixed with said predetermined amount of dilutant in said chamber wherein said device provides the dilute disinfectant solution at a fixed dilution determined by the ratio of the predetermined amount of said disinfectant solution to the predetermined amount of dilutant.

Abstract: Disclosed are devices, systems and methods for treating an incision. The device includes a generally planar tension relief module, comprising a central structure in fluid communication with the incision, wherein at least a portion of the central structure is adapted to be aligned with a longitudinal axis of the incision; and opposing adhesive structures coupled to the central structure and a flexible sealant structure comprising a lower adhesive surface and sized to seal over the tension relief module forming a sealed flow pathway. The opposing adhesive structures are adapted to be stretched from a relaxed configuration to a first tensile configuration and to return towards the relaxed configuration from the first tensile configuration into a second tensile configuration and impart a contracting force in a direction that is towards the opposing adhesive structure.

Abstract: A closing dressing bolster and assembly for use with a system for treating a linear wound on a patient includes a bolster body formed from a flexible closing bolster material having closing members that are operable to develop an inward closing force when the closing dressing bolster is placed under reduced pressure. In one aspect, when the closing dressing bolster is under reduced pressure, the system, dressing, or assembly develops an inward force realized at the linear wound and a compression force. A wicking-material holder and wicking material may be used as well. The member components may all be see-through to allow visual inspection of the wound without requiring removal of the dressing.

Abstract: An adhesive patch configured to attach an ostomy appliance to a patient includes a peripheral rim disposed around a central hole that is attachable to a stoma of the patient; and a band of adhesive extending from the peripheral rim to an inner border of the adhesive patch and having a pattern of curvilinear indentations extending to the peripheral rim of the patch.

Abstract: Pump cassettes, wound-treatment apparatuses and methods. In some embodiments, a pump cassette comprises: a pump body having a pump chamber, an inlet valve in fluid communication with the pump chamber, and an outlet valve in fluid communication with the pump chamber; a diaphragm coupled to the pump body such that the diaphragm is movable to vary a volume in the pump chamber; and an identifier configured to store one or more properties of the pump cassette such that the identifier is readable by an automated reader to determine the one or more properties. In some embodiments, the pump cassette is configured to be removably coupled to a wound-treatment apparatus having an actuator such that the actuator can be activated to move the diaphragm.

Abstract: Shunt devices and a method for continuously decompressing elevated intraocular pressure in eyes affected by glaucoma by diverting excess aqueous humor from the anterior chamber of the eye into Schlemm's canal where post-operative patency can be maintained with an indwelling shunt device which surgically connects the canal with the anterior chamber. The shunt devices provide uni- or bi-directional flow of aqueous humor into Schlemm's canal.

Abstract: Methods and devices treating an autonomic nervous system associated disease condition in a subject are provided. Aspects of the invention include inducing one or more physiological response selected from the group consisting of sweating, gastric emptying, enhanced heart rate variability and enhanced quantitative sensory test responsiveness in a manner sufficient to modify the autonomic nervous system so as to treat the subject for the disease condition. The methods and devices find use in a variety of applications, e.g. in the treatment of subjects suffering from conditions arising from disorders of the autonomic nervous system.

Abstract: A skin topical applicator apparatus includes an arm that has a first end and a second end. A cavity is positioned in the arm and is adjacent to the first end. A mount is attached to the arm and extends away from the first end of the arm. A roller is rotatably attached to the mount. A canister is removably mounted in the cavity and a nozzle is fluidly coupled to the canister and extends outwardly of the first end. The nozzle is directed toward the roller. The canister is filled with a fluid under pressure. The canister includes a valve that is actuated to release the fluid into the nozzle to coat the roller with the fluid.

Abstract: A novel system for coloring the sclera of a human eye, including steps of accessing the conjunctiva, drying a portion of the conjunctiva, applying one or more colorants to the dried portion of the conjunctiva, drying the colorant, and closing access to the conjunctiva. The system avoids tattooing, implanting, and corneal modification. Permanent results may be obtained. Colorants may be coverings or stains.

Abstract: The invention relates to novel chitin derivatives and their use in medical treatments of plastic surgery, dermocosmesis and therapy, in particular it relates to natural chitin derivatives, like chitin in nanofibrillar form, oxychitin and other chemical derivatives of chitin, chitosan-hyaluronate and associations for use as subcutaneous fillers or skin protectants.

Abstract: A method for suspending colorant in a subconjunctival space of a human eye, including steps of accessing the subconjunctival space, injecting colorant into the subconjunctival space, suspending colorant in the subconjunctival space, spreading the colorant into a desired pattern, and closing access to the subconjunctival space. The system avoids tattooing, implanting, and corneal modification. Permanent results may be obtained. Colorants may be suspensions or stains.

Abstract: A depilatory article comprising a substrate and a depilatory composition disposed on said substrate forming a coated region of the substrate, wherein at least a portion of the surface of the coated region of the substrate has an average surface free energy measured by the method herein of at least 30 mJ/m2, preferably from 31 mJ/m2 to 72 mJ/m2, more preferably from 32 mJ/m2 to 55 mJ/m2, even more preferably from 33 mJ/m2 to 46 mJ/m2 and even more preferably still from 34 mJ/m2 to 38 mJ/m2.

Abstract: Embodiments disclosed herein relate to methods, devices, and computer systems thereof for visibly or non-visibly indicating a subject has received a medical treatment. In certain embodiments, a subject receives an information mark in conjunction with a medical treatment. In certain embodiments, the information mark includes unique information relating to the subject. In certain embodiments, the information mark is fluorescent or phosphorescent. In certain embodiments, devices, computer systems, and methods relate to reading an information mark on a subject, and optionally determining if further medical treatment of the subject is warranted. In certain embodiments, receipt of an information mark entitles a subject to a reward.

Abstract: Disclosed are a sedative for external use, and sedative sheet, and textile, clothing, wall material, and hyperthermia equipment, brain vitalization sheet, brain vitalization small pillow which are with high productivity, adaptive for various shape and various treatment style for patients with pain, and with high treatment effect, comparing with conventional sedative for external use. A sedative for external use 10 is provided which is a bag 2 containing desert rose powder 1 prepared by pulverizing desert rose.

Abstract: A feminine hygiene garment containing a liquid pervious topsheet coated with a nonuniform pattern of a lotion composition is disclosed. The lotion composition is semi-solid or solid at 20° C. and is partially transferable to the wearer's skin. The lotion composition is applied to the article in a nonuniform manner, preferably such that there are regions on the article's topsheet that are not coated with lotion. In one embodiment the nonuniform pattern is a plurality of stripes of lotion that are separated by a plurality of stripes having no lotion.

Abstract: A tissue treatment apparatus and method are provided for treating tissue by the application of the time-varying sub-atmospheric pressure. The apparatus includes a cover adapted to cover a wound and adapted to maintain sub-atmospheric pressure the site of the wound. The apparatus further includes a source of suction configured to generate a time-varying sub-atmospheric pressure having a periodic waveform comprising a gradual change in pressure. The suction source cooperates with the cover to supply the time-varying sub-atmospheric pressure under the cover to the wound. The time-varying sub-atmospheric pressure may vary between a first pressure value below the inherent tissue tension of the wound tissue and a second pressure value above the inherent tissue tension of the wound tissue.

Abstract: Medical dressings and medical dressing kits that can be used to provide a ported medical dressing for placement over a wound or other body site where controlled fluid access is desired. The controlled fluid access provided by the medical dressings may be useful to remove fluids from the wound (as in, e.g., negative or reduced pressure therapies), to provide one or more gases to a wound site, to provide one or more liquids to a wound site, and/or to provide one or more active agents to a wound site. To achieve controlled fluid access, the medical dressing and medical dressing kits may include a port body with a lower surface that is adhesively adhered to the skin at the periphery of a wound or other body site.

Abstract: A tissue oxygenation device for creating and oxygen gradient that promotes the diffusion of oxygen from underlying capillaries and subcutaneous tissue up through and over an overlying target site of skin tissue, comprising: a gas impermeable encasement which forms a chamber which surrounds the target site when the encasement is positioned over the target site; an oxygen scavenging member comprising an oxygen scavenger, wherein the oxygen scavenging member is contained within the chamber such that the oxygen scavenger is exposed to oxygen within the chamber, and further wherein the oxygen scavenger removes oxygen contained within the chamber at a continuous rate; and an adjustable cuff, wherein the adjustable cuff comprises a pliable body which is attached to the gas impermeable encasement on an end of the body and to the target site at another end of the body; wherein the gas impermeable encasement and the adjustable cuff jointly operate to seal the target site within the chamber.

Abstract: A method, and apparatus for the controlled acceleration, and/or retardation of the body's inflammatory response generally comprises a foam pad for insertion substantially into a wound site, a heating, a cooling pad for application over the wound site, a wound drape or sealing enclosure of the foam pad, the heating, and cooling pad at wound site. The foam pad is placed in fluid communication with a vacuum source for promotion of the controlled acceleration or retardation of the body's inflammatory response. The heating, and cooling provision controls the local metabolic function as part of the inflammatory response.

Abstract: A sterilized non-discolored eyelid cleansing pad, which has been sterilized by exposure to ?-radiation in a dose level of 2 Mrad.

Abstract: A wound shield to manage repetitive access stress may include a conformable substrate to circumscribe a wound. Any suitable dressing may be secured to the conformable substrate providing separation between the wound and the dressing. The wound substrate may provide a site for attachment of adhesive dressings to shield the patient's skin from the pain of repetitive access and or removal of the dressings. A conformable substrate may be composed of one or more layers of any suitable material and may include adhesive on one or more surfaces to secure the substrate to the wound site and or to secure the dressing to the conformable substrate. A wound substrate may include strong adhesive to secure the substrate to the patients skin. The conformable wound substrate will be formed of any suitable non-absorbent material to permit long term application adjacent a wound. Thus many dressings may be applied and removed from a single wound substrate shielding the patient's skin from repetitive insult.

Abstract: A method of making a nonwoven web comprising nanofibers that are made by a melt film fibrillation process is disclosed. The nanofibers have a diameter of less than 1 micron, and comprise a significant number of the fibers in one layer of the web. The process generally includes the steps of providing a polymeric melt, utilizing a central fluid stream to form an elongated hollow polymeric film tube, and using this and/or other fluid streams to form multiple nanofibers from the hollow tube.

Abstract: A human skin treatment arrangement configured to treat surface conditions of human skin, especially the wrinkle, fine lines or scar appeared on the surface of human face, or for improving absorption efficiency of cosmetic or medical transdermal agent. In a treatment mode, the arrangement is configured for attaching to a portion of human skin such that the area of the human skin under treatment is maintained in a stretched position to enhance the treatment effect. In a further embodiment, the arrangement comprises a wrinkle relief agent, a scar relief agent or a cosmetic or medical transdermal agent to treat the surface of the skin.

Abstract: Apparatus for use with skin of a subject is provided, including a mount, a first zone of which is adhesively adherable to the skin. A second zone is not adhesively adherable to the skin. The mount is disposable in one shape and in another shape, at least one of the shapes being an unconstrained shape, the mount being deformable from the one shape to the other shape in response to application of a deforming force to the mount. When the mount moves toward the unconstrained shape, the movement is sudden regardless of a speed of application of the deforming force prior to the sudden movement. A treatment unit is provided, coupled to the mount, positioned with respect to the mount such that the treatment unit is moved into a position to apply a treatment to the subject by the mount moving toward the unconstrained shape. Other applications are also described.

Abstract: An apparatus for stimulating healing of a wound, includes a porous pad adapted to contact a surface of the wound on an affected part of a body. An envelope for receiving the porous pad and the affected part of the body is provided, and the envelope includes a re-sealable opening that permits the wound to be inspected. A connector is fluidly connected to an interior of the envelope and to a source of negative pressure.

Abstract: Medical devices possessing coatings are provided. The coatings include at least one polyelectrolyte, capable of changing the surface charge of the device to which they are applied. The polyelectrolytes permit attachment of charged bioactive agents thereto. Multiple polyelectrolytes, possessing opposite charges, may be sequentially applied to produce a medical device having multiple layers. Methods for forming such devices are also provided.

Abstract: According to some embodiments, a system for treating skin includes a handpiece assembly comprising a tip and a main body portion, the main body portion comprising an interior cavity and at least one canister configured to store at least one of a treatment material and a waste material. The treatment material and/or the waste material is in fluid communication with the tip.

Abstract: A dispenser containing a substance to be applied on a patient is described. The dispenser includes a plunger, a tube and a perforated element located inside the tube. The tube contains openings at its application end. When the plunger is pushed during application, the substance is squeezed through the perforated element and the openings and is applied to the patient. Selection of the height of the perforated element and presence or absence of alignment between the perforations of the perforated element and the openings allows control of the application of the substance on the patient.

Abstract: An instrument and technique for the removal of epidermal layers in a controlled manner utilizing a hand-held instrument with a working end that (i) a vacuum aspiration system, (ii) a source for delivery of a sterile fluids or pharmacological agents to the skin; and (iii) a skin interface surface in the working end that has specially shape structure for abrading surface layers of the patient's epidermis as the working end is moved over the patient's skin while at the same time causing rapid penetration of the fluids into the skin for therapeutic purposes. Movement of the working end across the skin causes abrasion of the surface layers in a path over the patient's skin. The method of the invention may be used in a periodic treatment for the removal of superficial skin layers that enhances the synthesis of dermal collagen aggregates by inducing the body's natural wound healing response.

Abstract: Apparatus for the provision of topical negative pressure therapy to a user is described, the apparatus comprising a device and a waste canister connected thereto, the waste 5 canister being operably connected for receiving wound exudate to a wound dressing by an aspiration conduit which is releasably connected to the dressing, wherein the waste canister has a blank connector portion thereon for sealably receiving a disconnected dressing end of the aspiration conduit.

Abstract: A method is provided for making punctal plugs by providing a fibrous strand and extrusion or dip coating the fibrous strand with a polymeric coating and cutting the coated fibrous strand to adequate length for insertion into a mammal body conduit, vessel, cavity, canal, artery, or vein.

Abstract: A synchronized water is disclosed, in which all single water molecules at the same time are arranged in an identical way to a stable homogeneous microstructure, wherein said synchronized water in a distilled condition and at atmospheric pressure has a) a density of from 0.997855 to 0.998836 g/ml at 22° C., b) a water temperature at the freezing point of from ?6.7° C. to ?8.2° C., c) a melting point of from 0.1° C. to 0.2° C., d) a surface tension of from 72.3 to 72.7 dyn/cm at 22 and e) a dielectric constant of from 82.4 to 82.6 F/m, as well as a method for preparation thereof and different uses thereof.

Abstract: Disclosed are advances in the arts with novel topical applicator apparatus for applying substances such as cleansers, cosmetic preparations and medications to the skin. The apparatus includes an applicator body having a power portion connected with an impulse portion, which in combination with an applicator head, transmits one or more various impulses to the skin supplemental to the substance applied. Exemplary preferred embodiments include configurations for providing mechanical and/or electrical or other impulses.

Abstract: A jig and a cooling fluid injection tool are provided for use in the correction of corneal shape of an eyeball. Correction of the eyeball takes place while the cornea is warmed. The jig includes a shape retention part of a sucking disc configuration having an inner surface side that contacts the eyeball and a grip part formed on an outer surface side of the shape retention part. An inner surface-sided cornea contacting section of the shape retention part is flattened and a cooling fluid injection hole passing through the grip part is formed in the center of the shape retention part with a diameter large enough for a wearer to see outside.

Abstract: Provided is a method of treating skin ulcers and related complications in patients by administering an oxidative reduction potential (ORP) water solution that is stable for at least twenty-four hours.

Abstract: Systems and methods for longevity, anti-aging, fatigue management, obesity, weight loss, weight management, delivery of nutraceuticals, and treating hyperglycemia, Alzheimer's disease, sleep disorders, Parkinson's disease, Attention Deficit Disorder and nicotine addiction involve synchronizing and tailoring the administration of nutraceuticals, medications and other substances (for example, stimulants) in accordance with the body's natural circadian rhythms, meal times and other factors. Improved control of blood glucose levels, extended alertness, and weight control, and counteracting of disease symptoms when they are at their worst are possible.