Abstract: In various embodiments of the invention, the components can include a hemostatic vacuum cup which can utilize ancillary or self-contained vacuum generation, and a therapeutic agent which is supplied prior, simultaneously or subsequent to the application of a vacuum with the ultimate aim of slowing or arresting the flow of blood in a bodily tissue or organ. The invention relates to a hemostatic vacuum cup which can utilize ancillary or self-contained vacuum generation. The cup produces a hemostatic effect by the physical application of the device upon a traumatized tissue site and through the delivery of an agent, such as one that assists in hemostasis, antinociception, coagulation, sterilization, or other effective wound healing agents including antibiotics, antiseptics and antioxidants. The cup can be adapted to deliver the therapeutic agent, by methods integral to the vacuum cup. The therapeutic agent can be delivered in the form of a sponge, cellulose or other filter material.

Abstract: Methods, systems, and software for controlling infusion pressure, such as during a medical procedure, using systemic blood pressure are described. Systemic blood pressure, such as brachial arm blood pressure or radial artery blood pressure, may be used to estimate central retinal artery blood pressure to estimate critical closing pressure. Further, the disclosure relates to controlling infusion pressure to prevent an increase in intraocular pressure above the estimated critical closing pressure when such is not desired, and, when such is desired, using systemic blood pressure and infusion pressure to control an intentional increase in intraocular pressure above the estimated critical closing pressure to stop intraocular bleeding.

Abstract: The invention is to provide a gas mist pressure bath system, which is possible to control the amount of gas and liquid, pressure and others, and cause a gas mist to be absorbed through a skin and mucous membrane of a human living body under an optimum condition.

Abstract: The invention is to provide a gas mist pressure bath system, which is possible to control the amount of gas and liquid, pressure and others, and cause a gas mist to be absorbed through a skin and mucous membrane of a human living body under an optimum condition.

Abstract: An endoluminal and intracorporeal negative pressure, wound care treatment, and prophylaxic system 10 and method includes a pressure distributor 40 for placement substantially within an internal organ or tissue abscess 34. A fluidic communication means 22 is provided between the pressure distributor 40 and a negative pressure source 20. A collection canister 24 is provided between the negative pressure source 20 and the pressure distributor 40 for collecting any effluents 36 that may be drawn from the abscess 34 during application of negative pressure. An introducing conduit 44 is provided for introducing the pressure distributor 40 into the abscess 34. A positioning conduit 46 is provided to properly position the pressure distributor 40 within the abscess 34. Negative pressure is applied to the pressure distributor 40 in order to provide negative pressure therapy within the abscess 34.

Abstract: A device used for applying an antiseptic preparation to a surgical site of a patient prior to surgery outside of an operating theater. A loose-fitting bag is provided which encloses the surgical site by securing the open end(s) to the patient by closing means. A high friction scrub surface is provided in the bag. A method and apparatus are also provided for releasing antiseptic into the interior of the bag. The method provides that the surgical site can be scrubbed within the bag so as to properly prepare the skin for surgery. A temperature indicator for the antiseptic preparation is also provided.

Abstract: A vacuum bandage is provided for use with a wound having a wound surface. The bandage is connectable to a vacuum source and includes a wound dressing member having a wound contacting surface, a top surface, and a port configured for communication with the vacuum source. The wound dressing member further includes holes in the wound contacting surface configured for communication with the wound surface of the wound and a passageway between the port and each hole. The vacuum bandage further includes a pack adjacent to the top surface of the member. The pack may include an aperture positioned about the port.

Abstract: The invention relates to a transdermal therapeutic system made of the following layers: a carrier layer (T), an active ingredient layer (R), a membrane layer (M) and optionally an adhesive layer (K), wherein the carrier layer (T) is impenetrable to the active substance and to water, the active substance layer (R) comprises as an active substance component the salt of an alkali reactive active substance, such as a CNS-active amine in combination with at least one alkali reactive further component, and a polymer component (P1), wherein the active substance is released from the active substance layer (R) only by the moisture entering from the exterior through the membrane layer (M), and the membrane layer (M) is made of a polymer component (P2), allowing a uniform delivery of basic active substances to the skin.

Abstract: An oil spray device is configured to include a casing unit which has an exit for allowing a user to enter the casing unit, spray units which are mounted on the inner surface of the casing unit to spray oil to skins of the user in the casing unit, and a means for distinguishing between clothes and skins which distinguishes clothes of the user from skins exposed out of the clothes, wherein the oil spray unit uses the means for distinguishing between clothes and skins to distinguish skins of the user from clothes of the user, and then selectively sprays oil to the skins of the user through the spray units.

Abstract: A skin treatment apparatus includes a handle body, a driving unit received in a receiving cavity of the handle body, a treatment head unit, and an inlet arrangement. The treatment head unit includes a supporting member provided at the front end portion of the handle body, a treatment cap detachably attached on the supporting member, a treatment shaft rotatably connected to the driving unit and extended from the driving unit into a treatment cavity, and an abrasion head integrally formed at a free end of the treatment shaft in such a manner that when the treatment shaft is driven to rotate, the abrasion head is also driven to rotate with respect to the handle body. The inlet arrangement is formed at the supporting member of the treatment head unit for providing a predetermined amount of skin treatment fluid in the treatment cavity.

Abstract: An antimicrobial sanitizer system for application of an antimicrobial material on skin or mucous membranes featuring a base handle (110) and a stem extending upwardly from the stem end of the base handle. The stem optionally is extendable from and retractable into an inner cavity in the base handle. The distal end of the stem is rounded and is adapted for insertion into the nasal cavity. At least a portion of the outer surface of the distal end of the stem features an antimicrobial material such as but not limited to copper.

Abstract: Various topical compositions for skin care are disclosed. These topical composition include: one or more acidic fermentation products derived from one or more (C1-C6) unsubstituted straight chain alcohols and branched alcohols; one or more alkali metal halides; one or more polysaccharides; and water. Methods of treating acne, seborrheic dermatitis, effects of ageing, blemishes, cleansing and treating skin, and the like, with these various topical compositions are also provided.

Abstract: The application describes a convenient portable kit for the application of topical medications. The kit can be used, for example, as a convenient system for application of cold sore medication. The kit includes a container for a quantity of fluid medication sufficient for several treatments together with a plurality of applicators for said medicine. The applicators are specially designed to apply the medicine accurately and with minimal pain.

Abstract: A method of treating burns, preferably second and third degree burns, by administration of an oxidative reduction potential (ORP) water solution that is stable for at least twenty-four hours is provided.

Abstract: A microprojection array comprising an approximately planar base and a plurality of microprojections, wherein the array comprises a therapeutic macromolecule and a stabilizing excipient. Described herein are microstructures having a proximal and distal layer, wherein the distal layer which contains the therapeutic molecule does not rely on the presence of a structure-forming polymer to impart the mechanical strength necessary to penetrate the skin. Methods of forming the array, and methods of using the array are contemplated.

Abstract: This invention relates to an apparatus that regulates thermodynamic energy-flow within a human body for producing beneficial effects such as, for example, improvement in strength, improvement in stamina, pain relief, etc. According to one embodiment, the invention provides a wearable apparatus that may include biomolecular components for building-up of a thermomagnetic energy within the human body. According to another embodiment, the invention provides a wearable apparatus that may include biomolecular components for dilution of a thermomagnetic energy within the human body. According to yet another embodiment, the invention provides a wearable apparatus that may include biomolecular components having orthomolecular and/or non-orthomolecular organic materials which are capable of thermomagnetic levororotary action and/or thermomagnetic dextrorotatory action.

Abstract: Compositions, devices, and methods for treating infections.

Abstract: A therapeutic patch for treating pain capable of compressing a tender area up to a boundary thereof and/or an entire induration with metallic grains or crushed stones by a treatment method in accordance with a classification determined after clarifying a site of pain by pressing a skin with a pressing bar or fingers (first to fourth fingers) to classify the cause of pain, thereby finding the presence of a geographical tender area and/or the presence of an induration on a skin as the cause of pain.

Abstract: An injection device has a dispensing chamber housing, a plunger, and a temperature control device. The dispensing chamber housing has a first part and a second part. The first part is thermally coupled to a needle. The second part is thermally coupled to the first part. The second part has an inner surface and an outer surface. The inner surface partially defines a dispensing chamber for holding a quantity of a substance. The plunger is engaged with an inner surface of the dispensing chamber housing, is capable of sliding in the dispensing chamber housing, and is fluidly sealed to the inner surface of the dispensing chamber housing. The temperature control device at least partially surrounds the dispensing chamber housing and is capable of altering a temperature of the substance in the dispensing chamber. The second part has a greater thermal coefficient than the first part.

Abstract: According to some embodiments, a microdermabrasion device for treating skin comprises a handpiece assembly having a distal end and a proximal end. The handpiece assembly includes at least one delivery conduit and at least one waste conduit. The microdermabrasion device additionally comprises a tip configured to be positioned along the distal end of the handpiece assembly, wherein the tip is adapted to contact skin surface. In several embodiments, the tip comprises a lip, a first opening in fluid communication with the fluid delivery conduit and a second opening in fluid communication with the waste conduit. In one embodiment, the device includes one or more abrasive elements positioned along a distal end of the tip, wherein the abrasive elements are configured to selectively remove skin as the tip is moved relative to a skin surface. In some embodiments, the delivery conduit is configured to selectively deliver at least one time-release material to the skin surface being treated.

Abstract: A method and apparatus for measuring a volume of a wound are described, the method comprising the steps of: applying a dressing over a wound, the volume of which is to be measured, the dressing including at least a sealing drape over the wound so as to create a sealed wound cavity; creating a vacuum in said wound cavity by vacuum pump means so as to produce a predetermined vacuum in the wound cavity; measuring a volume of air extracted from said wound cavity in producing said predetermined vacuum; and, calculating a volume of said wound.

Abstract: Provided is a device for treating tinea unguium which allows unrestricted treatment even for patients with basic diseases such as liver diseases, pregnant women and lactating patients and by which interindividual difference in the treatment can be avoided and antifungal agent for external use can be transdermally absorbed from the nail surface to the deep part of the nail economically, safely and efficiently within a short period of time without any side effects. A dome-shaped applicator, which is formed of a flexible material, which has an open part provided with a flange for adhesion and which is formed to have a larger film thickness in the periphery adjacent to the open part than the film thickness in other parts, is hermetically bonded to a surface of a nail. Then, the liquid antifungal agent for external use is fed into the dome-shaped applicator under pressure using an injector and is allowed to be efficiently penetrated into the deep part of the nail using positive pressure.

Abstract: A reduced-pressure treatment system for treating a wound on a patient includes a composite manifold that may help prevent or minimize injury to a wound edge of the wound being treated with reduced pressure. The composite manifold includes a perimeter manifold member and an inboard manifold member. The perimeter manifold member is designed to not collapse substantially under reduced pressure in a therapy range. The perimeter manifold member may be more rigid with respect to compressibility than the inboard manifold member. A sealing member is used to form a fluid seal over the wound, and a reduced-pressure subsystem provides reduced pressure to the composite manifold. Other systems, methods, and dressings are presented.

Abstract: Methods and devices are adapted for implanting into the eye. An incision is formed in the cornea of the eye and a shunt is inserted through the incision into the anterior chamber of the eye. The shunt includes a fluid passageway. The shunt is passed along a pathway from the anterior chamber through the scleral spur of the eye into the suprachoroidal space and positioned in a first position such that a first portion of the fluid passageway communicates with the anterior chamber and a second portion of the fluid passageway communicates with the suprachoroidal space to provide a fluid passageway between the suprachoroidal space and the anterior chamber.

Abstract: A sunless spray tanning device includes at least one peristaltic pump coupled to a spray gun. A liquid reservoir for housing a sunless tanning composition may be coupled to the inlet of the peristaltic pump. The composition is forced via the peristaltic pump to a spray nozzle located on the spray gun for application onto the skin of a customer. The spray gun includes a high volume, low pressure (HVLP) spray gun in some embodiments. A solenoid valve is disposed between the peristaltic pump and the spray gun in some embodiments. The spray gun may be mounted on a tanning booth apparatus or alternatively may include a handheld spray gun device for manual spray applications in various embodiments.

Abstract: The present invention provides an anti-microbial or anti-bacterial treated soft ointment applicator that is used to apply ointment or cream on babies. The ointment applicator with a soft and flexible tapered tip in the present invention can be applied along the curvature of a baby's body without causing harm to baby's sensitive and delicate skin. The present invention provides an anti-microbial or anti-bacterial treated ointment applicator either coated with, or homogeneously manufactured with, such anti-microbial or anti-bacterial protection. In addition, the present invention includes a reservoir filled with a cleaning solution where the ointment applicator is cleaned and stored sterile.

Abstract: A spray nozzle system for skin treatments includes separate air outlets moving over the skin surface to deliver one or more streams of supplemental air for the purpose of warming or drying the skin surface to improve efficacy and comfort of the spraying experience. The drying air from the auxiliary ports may be applied while spray is emitted from the nozzle to increase the spray cloud temperature, or may be applied before or after the spray application, with the spray turned off, to warm or dry the skin. A heating source is provided to warm the air directed through one or more heated air ports. In the case of air-atomizing nozzles, the heated air is delivered through low pressure ports separately from the air emitted through the nozzle's higher pressure atomizing and pattern shaping orifices to minimize the expansion cooling effect inherent with the spray nozzle ports.

Abstract: An apparatus for stimulating healing of a wound, includes a porous pad adapted to contact a surface of the wound on an affected part of a body. An envelope for receiving the porous pad and the affected part of the body is provided, and the envelope includes a re-sealable opening that permits the wound to be inspected. A connector is fluidly connected to an interior of the envelope and to a source of negative pressure.

Abstract: Shunt devices and a method for continuously decompressing elevated intraocular pressure in eyes affected by glaucoma by diverting excess aqueous humor from the anterior chamber of the eye into Schlemm's canal where post-operative patency can be maintained with an indwelling shunt device which surgically connects the canal with the anterior chamber. The shunt devices provide uni- or bi-directional flow of aqueous humor into Schlemm's canal.

Abstract: Disclosed are advances in the arts with novel topical applicator apparatus for applying substances such as cleansers, cosmetic preparations and medications to the skin. The apparatus includes an applicator body having a power portion connected with an impulse portion, which in combination with an applicator head, transmits one or more various impulses to the skin supplemental to the substance applied. Exemplary preferred embodiments include configurations for providing mechanical and/or electrical or other impulses.

Abstract: Test methods for assessing irritation of portions of skin are provided. The method may include irritating a portion of skin by contacting the portion of skin with a chemical irritant; irritating the portion of skin by physical irritation; and assessing erythema or dryness of the portion of skin after irritating the steps. Alternatively, the method may include irritating a portion of skin with a chemical irritant; irritating the portion of skin by physical irritation; treating the irritated portion of skin by wiping the irritated portion of skin with a test sample; and assessing erythema or dryness of the portion of skin after the wiping step. A method of irritating a portion of skin to assess one of erythema and dryness may include irritating a portion of skin with a chemical irritant and irritating the portion of skin by physical irritation.

Abstract: The invention provides transdermal delivery systems, medical kits, and methods for using the transdermal delivery systems and kits for medical applications, such as delivery of contraceptive agents to control fertility.

Abstract: A device used for applying an antiseptic preparation to a surgical site of a patient prior to surgery outside of an operating theater. A loose-fitting bag is provided which encloses the surgical site by securing the open end(s) to the patient by closing means. A high friction scrub surface is provided in the bag. A method and apparatus are also provided for releasing antiseptic into the interior of the bag. The method provides that the surgical site can be scrubbed within the bag so as to properly prepare the skin for surgery. A temperature indicator for the antiseptic preparation is also provided.

Abstract: A transdermal product delivery patch comprises a reservoir containing a product for delivery to a patient; means for affixing the patch to the skin of the patient; and manually operable means for actuating an extensor mechanism to exert pressure on the reservoir and thereby expel the product towards the skin. The patch may be supplied with the extensor mechanism held in a strained configuration and the manually operable means may be a restraint such as a peelable layer that can be removed to allow the extensor mechanism to move using stored energy towards a rest configuration. The extensor mechanism may be a ring of resilient material that is pre-stretched radially inwards so that, upon release, it stretches the reservoir radially outwards. The patch may be supplied with the extensor mechanism in a rest configuration and the manually operable means may deform it in a predefined manner into a strained configuration.

Abstract: The present invention is to provide a gas mist mask device which is compact and economical, and enables to take a mist bath for the face or the eyes by using the physiological actions of oxygen or carbon dioxide.

Abstract: One aspect of the invention is a method of treating a wound to clot blood. A sponge material is applied to the wound. The sponge comprises a starch having hemostatic properties and at least one binding agent. The sponge may further comprise a porous, flexible material.

Abstract: A transdermal delivery kit that enhances the efficacy of a topical drug includes at least one drug dispensing device, a lipophilic base, a hydrophilic base, a lipid-soluble active ingredient, a water-soluble active ingredient, a first container for mixing the lipophilic base with the lipid-soluble active ingredient to form a first compound, a second container for mixing the hydrophilic base with the water-soluble active ingredient to form a second compound, a mixing member, and instructions for compounding the lipophilic base with the lipid-soluble active ingredient to form the first compound, compounding the hydrophilic base with the water-soluble active ingredient to form the second compound, and mixing the first compound and the second compound to form a transdermal pharmaceutical delivery system capable of delivering a drug to the dermal layer of the skin.

Abstract: A garment for wear by a human body having a localized fat accumulation includes an insulative and perspiration impermeable panel sized to conform to the localized fat accumulation. The garment also includes a supportive cover connected to the panel for retaining the panel in contact to the localized fat accumulation during wear, and a boning segment connected to the panel for supporting and shaping the body during wear. The garment may be in the form of a kit further including a wipe containing an absorbed anticellulite agent. The wipe spreads the anticellulite agent on the body where contacted by the panel during wear.

Abstract: The invention is to provide a gas mist pressure bath device, which causes to contact carbon dioxide, oxygen or a mixed gas of carbon dioxide and oxygen to the skin or mucous membrane of the head of a living body at pressure higher than a predetermined value for efficiently enabling skin-pass absorption.

Abstract: The present invention relates to the use of a fully human antigen binding fragment of an antibody for the manufacture of a medicament for the treatment or diagnosis of an ocular disease upon topical administration. The invention further relates to a pharmaceutical composition comprising a fully human binding fragment of an antibody for ocular topical administration for treatment or diagnosis of an ocular disease. In particular, the antibody neutralizes HSV1 and HSV2.

Abstract: An emergency eyewash unit includes a pair of water discharge ports oriented to produce a pair of upwardly directed, diverging water streams for inside-out flush flow of contaminants from a person's eyes. These eyewash streams can be combined with a plurality of smaller upwardly directed facewash streams for flushing contaminants from a person's face. The eyewash and/or facewash streams are produced by an eyewash body adapted for rotatable mounting onto a water supply conduit, with a locking clip normally preventing undesired rotational disassembly. The eyewash body may be used in combination with an overhead emergency shower which, in one preferred form, includes a shower spray head carrying multiple flow control and flow shaper elements to produce a substantially uniformly dispersed shower spray pattern.

Abstract: Irrigation systems having splash shields attachable to bottles or syringes, also including abscess irrigation systems.

Abstract: A device for spraying a cosmetic or dermatological composition may comprise an ultrasound or electrostatic spray head, an airflow generator for entraining a spray of composition particles atomized by the spray head and a conditioning device, the conditioning device arranged to modify the temperature of the outgoing stream of air.

Abstract: The apparatus includes at least two skin-contacting elements, the elements having narrow end faces and a mounting assembly for holding the elements closely adjacent to each other. A driving assembly reciprocally moves one element relative to the adjacent element(s) at a frequency that produces an action on the pores of the skin to loosen sebaceous plugs present in the pores, by permitting their ready removal from the skin.

Abstract: A biocompatible wound dressing comprised of a pad for insertion substantially into a wound site and wound drape for sealing enclosure of the foam pad at the wound site. The pad, comprised of a foam or other like material having relatively few open cells in contact with the areas upon which cell growth is to be encouraged so as to avoid unwanted adhesions, but having sufficiently numerous open cells so that drainage and negative pressure therapy may continue unimpaired, is placed in fluid communication with a vacuum source for promotion of fluid drainage, as known in the art. The pad is further comprised of an ultra-low density fused-fibrous ceramic, or a bioabsorbable branched polymer, or cell growth enhancing matrix or scaffolding.

Abstract: Methods and devices are adapted for implanting into the eye. An incision is formed in the cornea of the eye and a shunt is inserted through the incision into the anterior chamber of the eye. The shunt includes a fluid passageway. The shunt is passed along a pathway from the anterior chamber through the scleral spur of the eye into the suprachoroidal space and positioned in a first position such that a first portion of the fluid passageway communicates with the anterior chamber and a second portion of the fluid passageway communicates with the suprachoroidal space to provide a fluid passageway between the suprachoroidal space and the anterior chamber.

Abstract: Methods and devices are adapted for implanting into the eye. An incision is formed in the cornea of the eye and a shunt is inserted through the incision into the anterior chamber of the eye. The shunt includes a fluid passageway. The shunt is passed along a pathway from the anterior chamber through the scleral spur of the eye into the suprachoroidal space and positioned in a first position such that a first portion of the fluid passageway communicates with the anterior chamber and a second portion of the fluid passageway communicates with the suprachoroidal space to provide a fluid passageway between the suprachoroidal space and the anterior chamber.

Abstract: A clamp and handle is designed exclusively for holding purchased containers of rub on and roll on pain killers, deodorants and any other substance that is in a container with a built in applicator. The handle is for applying these substances to hard or impossible places to reach due to anatomy or injury. The clamp, handle and knob are constructed from PVC that has a smooth glossy finish for the purpose of not causing any injury. The PVC can move smoothly over skin. The knob is flower shaped to make it easier to grip. The knob and clamp body prevent the stainless steel screw from scratching any skin. The screw will never rust.

Abstract: One applicator for use with ointment includes a housing defining a holding chamber. The holding chamber has a single entrance distinct from a single exit and is flexible such that deformation of the housing reduces capacity of the holding chamber and forces contents of the holding chamber to pass through the exit. A one-way valve is at the entrance for allowing the ointment to enter the holding chamber through the entrance and restricting the ointment from exiting the holding chamber through the entrance. A tip extends from the housing adjacent the exit. The tip has a proximal end meeting the housing and a pliant distal end spaced apart from the housing. The tip distal end is flared from the tip proximal end and has a generally planar leading surface. A channel in the tip extends from the exit to the leading surface, and is flared at the leading surface.

Abstract: Systems and methods of stimulating or activating fluids for use in wound treatment systems.