Abstract: The invention relates to a system for injecting a fluid through or into the human skin, optionally by needle-free injection or by injection with a needle, with (i) an injection device (110) which includes an ampoule (112) with an ampoule body (114) forming a chamber for receiving the fluid to be injected; an ampoule piston (118) which is axially movable and sealingly guided in the chamber; an outlet (124) disposed at the distant end of the ampoule (112) for the fluid to be injected, wherein the ampoule (112) is rounded in the region of the outlet (124) and the rounded region forms a skin contact surface (126) for the needle-less injection through or into the human skin; and at least one first coupling element (128) of a coupling device which is arranged at the distal end of the ampoule (112) on the ampoule body (114) and configured for sealingly and reversibly attaching a needle attachment (150), and (ii) a needle attachment (150) with a cannula part (152) comprising a needle (156); and an adapter part

Abstract: An easy-to-open end portion of a hermetically sealed container contains a substantially flat opening surface. The opening surface is free of broken pieces when the end portion is opened. The container comprises a tip portion, a truncated conical coupling portion for coupling the tip portion and a body portion, and a joint portion, wherein the tip portion, the joint portion, the coupling portion, and the body portion are arranged coaxially to have a central axis, and space portions are provided to extend continuously from the body portion to the middle of the joint portion. The joint portion can be broken by applying a force from the lateral direction of the central axis on the tip portion. As a result, the head portion of the truncated conical portion is exposed and the space portion of the coupling portion becomes a free end.

Abstract: An injector for injecting medicament in a patient. The injector includes a container comprising a fluid chamber containing a first volume of a medicament, and an injection conduit associated with the fluid chamber for defining a fluid pathway therefrom to inject the medicament from the fluid chamber through the injection conduit to an injection location. The injector also includes a firing mechanism associated with the fluid chamber for expelling the medicament from the fluid chamber through the injection conduit, and a volume-control mechanism operable to control a fraction of the first volume of medicament that is injected when the firing mechanism is actuated to inject the medicament.

Abstract: An injector system (100) for needleless, high pressure delivery of a medicament, the system comprising: an injector (102) having an injector piston (106) movable with in an injector body (104), a medicament container having a reservoir piston (119) movable in a reservoir (116), a fluid connection (118) interconnecting the injector body and an outlet (120) of the reservoir; and wherein the fluid connection is arranged such, with respect to the injector body, that upon movement of the reservoir piston towards a distal end, the medicament contained in the reservoir is pressurised whereby the injector piston is moved away from an initial position and the injector chamber is filled.

Abstract: A needle-less injector device for delivering a dose of fluid intradermally, subcutaneously or intramuscularly to an animal or human. The device includes an inner housing having opposed ends. A syringe is disposed in one end of the inner housing. The syringe includes a nozzle for delivering a dose of fluid held within the syringe. A plunger is movably disposed within the syringe. A spring powered hammer is movably disposed within the inner housing. The hammer cooperates with the plunger to drive the dose of medicament from the nozzle. An injection delivery spring for powering the hammer is positioned and compressed between the other end of the inner housing and the spring powered hammer. An outer housing slideably supports the inner housing. A skin tensioning spring is mounted between the inner housing and the outer housing, the skin tensioning spring biasing the nozzle of the syringe against the animal or human.

Abstract: The invention refers to an electrically actuated, needle-free injection device. The main field of application is drug delivery. The device is based on a piezoelectric actuator (11). The device enables controlled, continuous, tuneable drug delivery. The device enables painless injection, personalized and programmable dosage profiles. The device is designed, both to pierce the epidermis for trans-epidermal drug delivery and to deliver controlled amounts of fluid (transdermal, electronic pill and implantable drug delivery). This type of device enables personalized drug delivery and is an enabling component for closed-loop drug delivery systems.

Abstract: The invention relates to a needle-less injector having a housing comprising: a chamber defined within said injector for containing liquid to be injected; a liquid outlet for said chamber positioned at the front end of the injector, a dispensing member in contact with the liquid in said chamber and movable in a first direction to reduce the volume of said chamber to cause the liquid contained therein to be expelled through said liquid outlet; drive means for actuating said injector, wherein the dispensing member is a spring-loaded piston movable in said chamber by the spring in the first direction to a preferred position at which the volume of said chamber is at a minimum and the spring is nearly unloaded, and which piston is movable in a second direction opposite to the first direction by actuation of the drive means whilst counteracting a force from the spring and moving the piston to a non-preferred position at which the spring is loaded.

Abstract: The present application relates to a syringe device comprising an injector chamber and a medicament container each comprising a piston. In particular the present application relates to a device comprising motor arranged to move an injector piston and/or a reservoir piston so as to transfer a medicament in the medicament container to the injector chamber. Furthermore, the present application relates to a syringe device comprising a motor arranged to strain the spring for assisting the ejection action. Moreover, the present application relates to the use of a motor to strain a spring of a syringe device.

Abstract: The present invention relates to microscission methods and devices used for the manipulation or modification of the body tissue by the formation of microconduits in a tissue. The term “microconduit” refers to a small opening, channel, or hole into, or through, a tissue, that allows transfer of materials by liquid flow, and by electrophoresis, the microconduit being formed upon impact of a plurality of accelerated microparticles with the surface of the tissue. This process of “microscission” comprises forming at least one microconduit in tissue including the steps of: accelerating a plurality of microparticles to a velocity that causes the microparticles to penetrate a region of tissue surface upon impingement of the microparticles on the tissue surface; and directing the microparticle towards the region of tissue surface, thereby causing the microparticles to penetrate the tissue and form a microconduit in the tissue.

Abstract: Delivery systems for accessing the targeted tissue within the living being and introduction of at least one agent at select locations into the tissues of the heart such as the myocardium and other select tissues. Where appropriate, portions of the system are steerable to properly orient the device. When tissue penetration is utilized, the device may include a feature to control the depth of penetration. removal. The system may utilize some form of mechanical action or application of energy (e.g. electrical, sonic, thermal, optical, pressurized fluid, radio frequency (RF), nuclear) in the process. The agent delivered to the tissue may include one or more of pharmaceuticals, biologically active agents, radiopaque materials, etc.

Abstract: A needle-less fluid injection device, including, a nozzle head with an injection hole for accepting a dose of fluid to be injected into the skin of a patient, a fluid capsule that is connected to said nozzle head and provides the nozzle head with one or more doses of fluid for injection, an injection head for mounting the fluid capsule and the nozzle head; including a first mechanism for releasing a dose of fluid from the fluid capsule to the nozzle and a second mechanism for injecting the dose of fluid from the nozzle into the skin of a patient.

Abstract: A skin retention device 10 for a medical jet-injection unit 20 comprises a contact face provided with adhesive 12 in the area surrounding and close to the injection opening(s) 11 of the nozzle 21 which ensures god contact between the nozzle 21 and the skin 30 of a subject in the area chosen for an injection. Consequently the injection force can be lowered dramatically. In case of two-stage jet-injections, the initial injection force can be lowered because the skin retention close to the injection point significantly reduces the energy consuming elastic expansion of the skin 30 in the injection area, and the second injection force can be lowered because of the high degree of fixed positioning of the injection opening of the nozzle 21 relative to the injection channel in the skin 30 made during the initial injection stage. Thus a high degree of injection safety is achieved, minimizing the risk of whet shots, while skin lift and lower injection force decreases the risk of damage of the underlying tissue.

Abstract: The invention relates to an injection device which may or may not be equipped with a needle, comprising an injection nozzle and a tube which is intended to receive the active substance to be injected, whereby the tube is fixed to the nozzle using connecting means. The inventive device is characterized in that the aforementioned connecting means comprise at least three identical bosses which are solidly connected to the nozzle. Moreover, each of said bosses comprises an inclined part which terminates in a flange, said flange co-operating with a collar which is formed on the tube and acts as a backstop for the tube when the latter is connected to the nozzle.

Abstract: Needle-free injection devices having a delivery system to effect an injection and a body configured to house the delivery system. The delivery system includes an injectate assembly adapted to house a volume of liquid and a drive assembly adapted to expel the volume of liquid from the injectate assembly. In some embodiments, the drive assembly includes a pair of parallel springs. The device further includes a priming system adapted to prepare the device for delivery of an injection. The priming system includes a force-preparation assembly adapted to selectively arrange the drive assembly to provide the drive force to the injectate assembly. In some embodiments, the priming system includes a locking assembly adapted to releasably retain the injectate assembly relative to the body. In some embodiments, the priming system includes a dosing assembly adapted to selectively draw a volume of liquid into the injectate assembly.

Abstract: In certain embodiments, a vial adaptor for removing liquid contents from a vial comprises a piercing member and a bag. The bag can be contained within the piercing member such that the bag is introduced to the vial when the vial adaptor is coupled with the vial. In some embodiments, the bag expands within the vial as liquid is removed from the vial via the adaptor, thereby regulating pressure within the vial. In other embodiments, a vial comprises a bag for regulating pressure within the vial as liquid is removed therefrom. In some embodiments, a vial adaptor is coupled with the vial in order to remove the liquid. In some embodiments, as the liquid is removed from the vial via the adaptor, the bag expands within the vial, and in other embodiments, the bag contracts within the vial.

Abstract: A method of distributing particles in a flow of gas and a needleless syringe for use in the needleless injection of particles into the skin or mucosa of a vertebrate subject are disclosed. The syringe includes a convergence which reduces pressure of the gas flowing in the gas flow path due to the Venturi effect such that particles initially located outside of the gas flow path are drawn into the gas flow path under the action of the reduced pressure and become entrained in the gas. An exit nozzle accelerates the particles so entrained. In another aspect of the invention, there is provided a method of creating a gas flow in a needleless syringe which comprises flowing gas through a first convergence into a chamber to form a transsonic gas jet in the chamber and passing the gas jet from the chamber into a second convergence and along the nozzle.

Abstract: Needle-free injection devices having a body, an actuation system, and a delivery system including a drive assembly and configured to receive a nozzle assembly. In some embodiments, the drive assembly includes a spring and a support member configured to restrict movement of the spring in a direction non-parallel to a central axis of the spring. In some embodiments, the drive assembly includes a transmission assembly configured to couple a drive source with the actuation system upon engagement of a nozzle assembly with the drive assembly. In some embodiments, the body is configured to acoustically seal an interface between the delivery system and the actuation system. In some embodiments, the body includes a gripping member selectively extendable from the body.

Abstract: The object is to provide an ampoule usable as a syringe, and a syringe unit which are easy to handle, excellent in quantitative accuracy, and further more excellent in hygienic aspect. The above object is solved by an ampoule usable as a syringe comprising: a front edge portion (4) which is removed when the ampoule is used; an ampoule body (2) which can accommodate a drug solution (10); and a liquid infusing portion (3) connecting the front edge portion (4) and the ampoule body (2); the ampoule body (2) being able to place a movable stopper (5) in contact with an internal surface of the ampoule body (2), and being able to accommodate the drug solution (10) hermetically-sealed in the through-hole (6) between the movable stopper (5) and the sealing portion (4a).

Abstract: The invention concerns the field of needleless syringe having an injector with several ducts. The problem that needs to be solved is the long term compatibility of the injector with the liquid active principle. For that purpose the syringe (1) comprises a cylindrical reservoir (2), closed at its upstream part by a closure element (3) capable of being moved by driving means (70), and closed at its downstream part by an injector (4) comprising at least an injection duct and said reservoir being secured to the body (8) of the syringe, said syringe is such that the diaphragm (5), compatible with the active principle, isolates the latter from the injector (4) and said diaphragm can be passed through by the liquid (6) when pressurized for injection.

Abstract: In certain embodiments, a vial adaptor for removing liquid contents from a vial comprises a piercing member and a bag. The bag can be contained within the piercing member such that the bag is introduced to the vial when the vial adaptor is coupled with the vial. In some embodiments, the bag expands within the vial as liquid is removed from the vial via the adaptor, thereby regulating pressure within the vial. In other embodiments, a vial comprises a bag for regulating pressure within the vial as liquid is removed therefrom. In some embodiments, a vial adaptor is coupled with the vial in order to remove the liquid. In some embodiments, as the liquid is removed from the vial via the adaptor, the bag expands within the vial, and in other embodiments, the bag contracts within the vial.

Abstract: A needle-free injector with a mechanism to adjust the volume of liquid administered is provided. The injector includes a power base, a fluid path having a plunger to force substances from a cavity defined within the fluid path, and a dose adjustment assembly for adjustably positioning the fluid path relative to the power base to adjust the volume of substance administered to the subject.

Abstract: The invention relates to needle-free apparatus that can be used to augment soft tissue. More specifically, the needle-free injectors of the present invention allow injection of more viscous materials such as collagen, hyaluronic acid, and other polymers that are useful as dermal fillers. The needle-free injectors of the present invention allow injection of such materials to fill the undesired lines, wrinkles, and folds of a patient. The present invention also relates to kits comprising such needle-free injectors and a quantity of dermal filling material. In addition, the present invention relates to methods of augmenting soft tissue using needle-free apparatus.

Abstract: The invention relates to a device for injecting a fluid including a pressure chamber for accommodating the fluid, a piston for expelling the fluid from the pressure chamber, a pressure mechanism for generating an expelling impulse or force, and a transfer body coupled to the pressure mechanism, wherein, in an initial position the transfer body is arranged at a distance away from a contact point for transferring a force or impulse onto the piston. The invention encompasses a method for injecting a fluid wherein a transfer body is freely accelerated for a distance and strikes a contact point thus generating an initial impulse or pressure to expel the fluid.

Abstract: The invention relates to a needleless injection device (1) comprising a body (2) which supports and/or defines a plurality of elements that form a circuit of elements. The aforementioned circuit comprises, from upstream towards downstream, an initiation device which is associated with a pyrotechnic gas generator, a receptacle (5) housing a liquid active agent that is to be injected, and an active agent injection system. According to the invention, the pyrotechnic gas generator comprises a pyrotechnic charge (62) which is placed in a combustion chamber (4). The inventive device is characterised in that it comprises at least one device for regulating the gas pressure level in the combustion chamber (4).

Abstract: A needle-less injector device that includes an outer housing and an inner housing that is slideably supported from the outer housing is disclosed. The inner housing supporting a vial that includes a nozzle for delivering a fluid held within the vial. A spring powered ram that is adapted for pushing a seal and plunger is mounted within inner housing. A skin tensioning spring mounted between the inner housing and the outer housing is used for pushing the leading end of the inner housing away from the outer housing. A trigger that cooperates with the spring-powered ram is used to release the ram from the cocked position only when the inner housing is in a firing position.

Abstract: A method for filling needleless injector capsules with liquid drug, whereby dissolved gas within the drug is replaced by a less soluble gas in order to reduce the inclusion of gas bubbles, or to prevent the growth of bubbles during storage and thereby prevent breakage of the capsules.

Abstract: An injection channel is produced in human or animal tissue by means of a pre-injection device for incorporating a medium which is to be injected. Said pre-injection device comprises a chamber which is used to receive a pre-injection medium, a nozzle which is provided for attachment to the skin and a pressure generating device which acts on the chamber in order to generate a high-pressure jet from the pre-injection medium exiting from the nozzle. Said type of needle-free pre-injection device is serially connected to a main injection device.

Abstract: A needle-free injection device, including a plunger and a spring operatively coupled with the plunger. The plunger is slidably disposed within a fluid chamber, is retractable to draw injectable fluid into the fluid chamber through an injection orifice, and may be advanced within the fluid chamber to forcibly eject injection fluid out through the injection orifice. The spring is configured to be compressed during arming of the injection device, and decompressed during discharge to forcibly advance the plunger within the fluid chamber. The injection device further includes an actuator operable to cause the spring to be compressed during arming of the injection device, and selectively operable prior to decompression of the spring to cause the plunger to be moved to a desired position within the fluid chamber.

Abstract: The invention provides a device which seeks to ensure that substantially all the particles delivered avoid interaction with the so-called “starting process”. There is provided a needleless injection device comprising a driver chamber (51) arranged, in use, to contain a charge of pressurised gas, a duct section (52) connected to the driver chamber (51) to receive gas therefrom and a closure means (53) for preventing the flow of gas from the driver chamber (51) to the duct section (52) until the closure means (53) is opened. Further, a dose of particles (58) is positioned within the device in the region of the closure means (53).

Abstract: An injector includes a housing having a chamber for holding a liquid formulation of an active principle to be injected into a biological body and an output port in fluid communication with the chamber through which the liquid formulation is injected. A piston is positioned within the housing, and includes an end portion with substantially the same shape as the chamber. A magnetic force draws the piston and housing together to expel the liquid formulation out of the chamber through the output port.

Abstract: A medicine bottle assembly includes a medicine bottle having a storage cavity and an outlet port, with the outlet port disposed on an exterior of the bottle and in fluid communication with the storage cavity. Liquid medicament is disposed in the storage cavity and defines a current fluid level. The outlet port is advantageously disposed entirely below the current fluid level and oriented generally upward. The outlet port is operative to selectively allow flow of the medicament out of the bottle. The assembly may further include a needless syringe having an angled tip. The exterior of the bottle may include a recess disposed above the outlet port, with the recess adapted to receive and retain the syringe. The recess is advantageously aligned with the outlet port. Other aspects and methods are also disclosed.

Abstract: A needleless injector generally includes a barrel having a proximal and a distal end and a bore therethrough along with an injection head disposed at the barrel distal end in fluid communication with the bore; an energy source is disposed at the barrel proximal end and a bolt may be disposed in said bore for reciprocating movement therein, from a first position to a second position for drawing medicament into the bore, the bolt being fitted in the bore in order to force medicament through the injection head upon movement of the bolt from the second to the first position. A mechanism is provided for activating the energy source in order to operate the bolt.

Abstract: Formulations are described that are viscous and will benefit from needle-free delivery at high driving pressures. Conventional delivery of these viscous formulations by hypodermic syringes is inconvenient as well as painful. Formulations include those which have a viscosity of about 5 cS or more at about 20° C. and which can have 0.5 ml or more administered by a needle-free injector in about 0.1 second±0.02 seconds.

Abstract: Needle-free injection devices and drug delivery systems are disclosed. The needle-free injection devices may include a drug delivery system, a power source, an activation system, and a disabling element. The drug delivery system may include a needle-free syringe and a drug storage system. The needle-free syringe may include a plunger slidably disposed within an injection chamber. The injection chamber may include an injection orifice, and the plunger may be configured to expel a volume of fluid from the injection chamber through the injection orifice. The drug storage system may include a storage chamber and an outlet. The drug storage system may be frangibly connected to the needle-free syringe with the outlet proximate to and fluidly connected with the injection orifice. The drug storage system may be configured to inject a fluid from the storage chamber through the outlet, through the injection orifice, and into the injection chamber.

Abstract: The present invention relates to an injection device comprising a housing, a resilient member adapted to provide a force in the axial direction of the injection device for ejecting a dose from the injection device. The injection device further comprises a dose setting member operatively connected to a dose indicator barrel positioned within the housing, the dose setting member and the dose indicator barrel being movable relative to each other and cooperating to set the dose to be ejected from the injection device. The dose indicator barrel undergoes, during dose setting, a combined rotational and translational movement within the housing and relative to the housing.

Abstract: The invention relates to the realm of needleless syringes used for injecting liquid active substances. Said syringe comprises a reservoir that is enclosed by means of displaceable plugs which trap the liquid. The reservoir is initially isolated from an injector-receptacle (37) which is provided with at least two peripheral injection conduits (38) that are arranged outside the receptacle (37). Said receptacle (37) encompasses a pocket bore (31) which accommodates the plug located downstream such that the optimized inlets (39) of the conduits are unobstructed. The face of the receptacle (37), which is located upstream, comprises a multilobed sealing joint (34) which is disposed parallel to and as close as possible to the edges of the bore (31) and the inlets (39). The aim of the invention is to create an injector-receptacle (37) that is optimized regarding discharging and the resistance thereof to the injection pressure.

Abstract: The present invention provides an injection delivery system for the injection delivery of at least two fluid doses to a small bird by penetrating the skin of the recipient bird with at least on injection needle. The present injection delivery system comprises an injection needle device and a metering device. The injection needle device can either be a stationary unit or a hand held device.

Abstract: Needle-free injection devices having a delivery system to effect an injection and a body configured to house the delivery system. The delivery system includes an injectate assembly adapted to house a volume of liquid and a drive assembly adapted to expel the volume of liquid from the injectate assembly. In some embodiments, the drive assembly includes a pair of parallel springs configured to simultaneously deliver a drive force to the injectate assembly. The device further includes a priming system adapted to prepare the device for delivery of an injection. The priming system includes a force-preparation assembly adapted to selectively arrange the drive assembly to provide the drive force to the injectate assembly. In some embodiments, the priming system includes a locking assembly adapted to releasably retain the injectate assembly relative to the body. In some embodiments, the priming system includes a dosing assembly adapted to selectively draw a volume of liquid into the injectate assembly.

Abstract: A one-way injector having a housing in which at least one mechanical spring energy store, at least one piston/cylinder unit, which can be at least temporarily filled with an active substance, at least one piston-actuating plunger and at least one tripping unit are arranged. To this end, the spring energy store comprises a preloaded spring element. The spring element is held in the preloaded position by a tension means surrounding at least a region of the spring. The tripping unit comprises a cutting tool which, in order to release the energy of the spring energy store, severs or weakens the tension means at least one point, the weakening immediately tearing the tension means. With the present invention, a one-way injector is developed which, with a small overall size, has only a few components and ensures reliable mounting and functioning with simple manipulation.

Abstract: The technical field of the invention is that of pre-filled and disposable needleless syringes, used for intradermal, subcutaneous and intramuscular injections of liquid active principle for therapeutic use in human and veterinary medicine. The inventive syringes (1) are mainly characterized in that they function with a pyrotechnic charge (6) consisting of a mixture of powder with high burning rate and a powder with low burning rate. Indeed, the combustion of the powder with a high burning rate enables to communicate instantly, through a piston (3), a very high speed to the active principle (4), whereas the combustion of the powder with a low burning rate enables to maintain a threshold pressure level to proceed with the injection, so as to ensure that the active principle (4) penetrates through the skin. Thus, the injection is properly and homogeneously without any loss of active liquid (4).

Abstract: Needle-free hypodermic jet injection devices having an actuation system to effect an injection from a drug delivery system. The actuation system includes an injection force assembly adapted to transmit a driving force to the drug delivery system. The actuation system further includes a trigger assembly adapted to alter the actuation system between a plurality of configurations including a fired configuration in which the injection force assembly transmits a driving force to the drug delivery system. In some embodiments, the device has a recoil restriction system including a restriction member adapted to couple the recoil restriction system to the trigger assembly and a recoil member coupled to the injection force assembly and movable relative to the restriction member. The restriction member limits movement of the recoil member once the recoil member moves a predetermined distance relative to the restriction member.

Abstract: In certain embodiments, a vial adaptor for removing liquid contents from a vial includes a piercing member and a bag. The bag can be contained within the piercing member such that the bag is introduced to the vial when the vial adaptor is coupled with the vial. In some embodiments, the bag expands within the vial as liquid is removed from the vial via the adaptor, thereby regulating pressure within the vial. In other embodiments, a vial includes a bag for regulating pressure within the vial as liquid is removed therefrom. In some embodiments, a vial adaptor is coupled with the vial in order to remove the liquid. In some embodiments, as the liquid is removed from the vial via the adaptor, the bag expands within the vial, and in other embodiments, the bag contracts within the vial.

Abstract: A method for filling needleless injector capsules with liquid drug, whereby dissolved gas within the drug is replaced by a less soluble gas in order to reduce the inclusion of gas bubbles, or to prevent the growth of bubbles during storage and thereby prevent breakage of the capsules.

Abstract: A monitor either usable in cooperation with or apart from a portable cooler to maintain a temperature of medications. The cooling device defines an interior volume for holding the medications, a power source including at least one of a 12 volt DC and an attachable 110 volt AC supply. A portable monitoring device is integrated with the cooling device and further includes a processor driven circuitry for recording a temperature associated with the interior volume containing the medications. The recorded temperature is compared at determined intervals to a preset programmed temperature range and, upon exceeding the programmed range, the device alerts the user. An alternative monitoring device is envisioned to ship with the medication from the manufacturer and remain with the medication container until the medications are used.

Abstract: In the present invention, the impedance between patient's body and the jet injection drug delivery device is measured through the liquid jet during the drug delivery process. The liquid jet completes the electrical circuit formed by impedance monitor, drug delivery device, and the patient's body. When the jet pierces stratum corneum, the impedance in the circuit immediately decreases, thus an indicating the successful drug delivery. The impedance monitor then provides a signal, visible, audible, or electronic, indicating that the process of the drug delivery through skin was successful.

Abstract: Needle-free injection devices having a drive assembly to provide an operative force to effect an injection and a dosing assembly to prepare the device for a subsequent injection. In some embodiments, the dosing assembly is configured to transfer injectate from an injectate source to the injectate assembly. In some embodiments, a portion of energy available to the drive assembly urges the injectate towards the injectate assembly. In some embodiments, the device includes a nozzle assembly having one or more ports.

Abstract: A dispensing device, such as a needle free injector, comprising a spring which provides an energy store, and a dispensing member movable to effect dispensing under the force of the spring, a latch having a first, safe position which disables triggering of the device, a second, ready to trigger position in which it restrains movement of the dispensing member but enables triggering, and a third, triggered position in which it permits such movement. A trigger is operable by the user for moving the latch from the second position to the third position. A safety mechanism, preferably in the form of an appropriately shaped slot in the dispensing member, is effective before triggering the device to prevent movement of the latch to the third position. An attachment is provided for moving the latch from the first, safe position to the second, ready to trigger position to enable triggering of the device.

Abstract: The invention relates to needleless syringe for injecting an active liquid principle. The inventive syringe comprises a container (3) closed by a movable shutter and containing the injectable liquid. Said container is initially insulated from an injector-receptacle provided with a cylinder bore (10) in which a downstream shutter is arranged and which comprises at least one protuberance reducing the section with respect to the upstream opening of the bore. The aim of said invention is to damp and prevent the downstream shutter bounce when it is disposed in the bore (10) of the receptacle.

Abstract: A needleless syringe for subcutaneously delivering a therapeutic agent comprising a generally constant diameter elongate tubular nozzle and an inert gas reservoir thereto is described herein. The reservoir is advantageously mounted to the upstream end of the tubular nozzle through a contraction that is either gradual or sudden and wherein a membrane is positioned between the reservoir and the therapeutic agent.

Abstract: Improved methods and apparatus that make more accurate and reduces risk of filling reaction chambers of cartridge cells with blood samples to conduct blood coagulation tests of the type employing the plunger technique are disclosed. A cartridge holder is provided that secures a test cartridge in a fixed upright position and deflects the plunger flag of each cartridge cell to enable manual insertion of a blood dispenser deeply into the reaction chamber to fill the reaction chamber and avoid contamination of surfaces of the cartridge outside the reaction chamber. Preferably, the cartridge holder provides illumination of the reaction chamber during filling, so that the user can judge when the reaction chamber is properly filled with blood dispensed from the blood dispenser. The cartridge holder may incorporate image magnification to facilitate viewing of the reaction chamber as it is filled.