Abstract: Described herein are various methods to ensure safety and the compliance of therapeutic diabetes protocols. The method can be achieved by performing safeguards against hypoglycemia of the user prior to any change in basal insulin dosage based on the plurality of data.

Abstract: A method is provided for classifying incoming products (e.g., chicken butterflies) to be portioned into two or more types of end products (e.g., sandwich portions, strips, nuggets, etc.) to meet production goals. The method includes generally five steps. First, information on incoming products is received. Second, for each incoming product, a parameter value (e.g., the weight of an end product to be produced from the incoming product) is calculated for each of the two or more types of end products that may be produced from the incoming product. Third, the calculated parameter values for the incoming products for the two or more types of end products, respectively, are normalized so as to meet the production goals while at the same time achieving optimum parameter values. Fourth, for each incoming product, the end product with the best (e.g., largest) normalized parameter value is selected as the end product to be produced from the incoming product.

Abstract: Methods of determining the source of an unknown sample are disclosed. Mass spectra from possible sources are obtained using two-dimensional gas chromatography coupled with time-of-flight mass spectrometry. That data is processed to obtain a dataset. A random forest algorithm is used to classify the dataset and create a classifier that distinguishes between the possible sources.

Abstract: A method for determining a turbidity point and a free carbohydrate buffer coefficient of an iron-carbohydrate complex. The method includes: (1) contacting the complex with an acid; (2) determining hydrogen ion concentrations and solution turbidities of the complex in acid degradation; and (3) mathematically fitting the data, to obtain the turbidity point of the complex and the free carbohydrate buffer coefficient through mathematical treatment. A method for evaluating the safety of the iron-carbohydrate complex with the turbidity point and the free carbohydrate buffer coefficient.

Abstract: Disclosed is a method for prediction of a film material such as a raw material for organic EL. In the method, a film material having an evaporation rate (V(%)) represented by the formula below can be predicted based on the values of the constant (Ko) and the activation energy (Ea). V=(Ko/P)×e?Ea/kT wherein Ko represents a constant (%·Torr), P represents a pressure (Torr), Ea represents an activation energy (eV), k represents a Boltzmann constant, and T represents an absolute temperature.

Abstract: A method for determining the composition of a material including the steps of fitting multivariate analytical data of the material to a combination of multivariate analytical data in a database to determine coefficients of the combination so as to determine a reference model of composition based on the coefficients and the compositions in the database, wherein the database includes multivariate analytical data of database materials whose compositions are known, and reconciling the reference model of composition to match properties of the material.

Abstract: The present invention relates to a method of qualifying ovarian cancer status in a subject comprising: (a) measuring at least one biomarker in a sample from the subject and (b) correlating the measurement with ovarian cancer status. The invention further relates to kits for qualifying ovarian cancer status in a subject.

Abstract: Disclosed is a method for detecting one or both of the native material in an object and any foreign material in the object by parallel-mode spectroscopy, comprising parallel-mode data acquisition, signal processing and data reduction and providing results. Parallel-mode data acquisition comprises producing an interrogating signal simultaneously containing electromagnetic radiation of sufficient bandwidth in the range of approximately 10 GHz to approximately 25 THz to allow simultaneous detection of a plurality of signals at a plurality of frequencies, each signal being at some amplitude, which collectively provide a unique spectral signature of a material whose detection is desired. The signal processing and data reduction comprises processing a signal resulting from exposing the object to the interrogating radiation to produce a three-dimensional data matrix representative of at least any foreign or native material associated with the object.

Abstract: An analyzer which acquires first measured data relating to a first parameter and second measured data relating to a second parameter, the first and second measured data being obtained by measuring an analyte, forms a two-dimensional distribution chart that indicates a distribution of tangible components contained in the analyte based upon the first and second measured data, with the first and second parameters being set as two axes of the two-dimensional distribution chart, sets an area on the two-dimensional distribution chart, and forms a frequency distribution chart with respect to tangible components belonging to the area, with the first parameter being set as an axis of the frequency distribution chart is disclosed.

Abstract: A pattern matching unit performs pattern matching on present data obtained this time in clinical examination of a part of a subject and previous data obtained last time in the clinical examination of the part with reference patterns. Reference patterns that are most closely approximate to the present data and the previous data are selected. A distance calculator calculates a distance between selected reference patterns. A determining unit determines whether a re-examination is necessary based on the distance.

Abstract: A plant information management system comprising: a seed identification information input device; an individual plant identification information retrieval device; an individual plant identification information input device; a new seed identification information retrieval device; a storage location information retrieval device; a project database management device; a seed database management device; a project database memory device; and a seed database memory device.

Abstract: A medical device for providing information for glycemic control is provided, wherein the device comprises a storage unit arranged to store information on an initial dose of insulin and to store information on a blood glucose level measured after the initial dose of insulin was administered and after specific food was consumed, and a determining unit arranged to determine a subsequent dose of insulin to be administered before the specific food is consumed based at least on said information on the initial dose of insulin and said information on the blood glucose level.

Abstract: A fluid analyzing system comprises an electronic control module and a telematics device. The electronic control module is coupled with an asset. The electronic control module is configured for initiating acquisition of a sample of a fluid of the asset and initiating a microfluidic analysis of the sample in response to occurrence of an analysis trigger. The analysis trigger comprises an operating characteristic of the asset. The telematics device coupled is coupled with both the asset and the electronic control module. The telematics device is configured for wirelessly transmitting results of the microfluidic analysis to an asset management system located remotely from the asset and the telematics device.

Abstract: A method of controlling a fuel cell system includes applying alternating current (AC) signals to an individual fuel cell. The AC signals have a plurality of different frequencies. A voltage across the individual fuel cell is determined at each of the plurality of different frequencies. An impedance characteristic of the individual fuel cell is determined based at least in part on the voltage across the individual fuel cell at each of the plurality of different frequencies. The individual fuel cell is controlled based at least in part on the impedance characteristic.

Abstract: A method and a system is disclosed for determining RON and/or MON values from constant volume combustion chamber apparatuses capable of producing pressure versus time combustion profiles having a fast combustion region and a slow combustion region, where data from the two regions is used to compute RON and/or MON values for light distillate fluid samples using a series expansion equation.

Abstract: A computer system for recommending an optimal treatment protocol comprising a model of biological processes related to a disease. A treatment protocol generator generates a plurality of treatment protocols for treating a disease using drugs. A selector selects an optimal treatment protocol from the plurality of treatment protocols based on model. The model further comprises a pharmacokinetics macro module adapted to analyze interactions between a ligand and a population of target cells at a tissue level. The model further comprises a pharmacokinetics micro module adapted to analyze interactions between the ligand and a cell at an individual cell level. The pharmacokinetics micro module is adapted to model behavior of the ligand and receptors related to single cell level of ligand-cell interactions, as a stochastic process.

Abstract: We have created novel engineered genetic counter designs and methods of use thereof that utilize DNA recombinases to provide modular systems, termed single invertase memory modules (SIMMs), for encoding memory in cells and cellular systems. Our designs are easily extended to compute to high numbers, by utilizing the >100 known recombinases to create subsequent modules. Flexibility in our engineered genetic counter designs is provided by daisy-chaining individual modular components, i.e., SIMMs together. These modular components of the engineered genetic counters can be combined in other network topologies to create circuits that perform, amongst other things, logic and memory. Our novel engineered genetic counter designs allow for the maintenance of memory and provide the ability to count between discrete states by expressing the recombinases between their cognate recognition sites.

Abstract: The method for measuring the properties of petroleum fuels by distillation relates to a measuring method for predicting the property values of complex hydrocarbon fuels, such as the property values of gasoline, by distillation. Compensation of boiling point distribution measurements used for the prediction of physical properties of hydrocarbons is further performed.

Abstract: Systems and methods are provided for analyzing data to determine properties of a PCR processor other process exhibiting amplification or growth. Data representing an amplification can be distinguished from data representing a jump or other error. A modified sigmoid function containing a drift term may be used in determining the properties. A multi-stage functional fit of the amplification data can provide increased accuracy and consistency of one or more of the properties. A baseline of the amplification data can be determined by analyzing an integrated area of a first derivative function of the data. A reference quantitation value can also be determined from locations of maxima of different derivative functions of the amplification data, e.g., a weighted average of the maxima locations for the second and third derivatives may be used.

Abstract: A method for identifying peptides using tandem mass spectrometry takes the spectrum for a peptide to be analyzed and uses a scoring function to score a match between the spectrum and each candidate peptide in a peptide database. The scoring function has a value corresponding to a number of fragment peaks in the spectrum that match fragment peaks in a spectrum of the candidate peptide. Using the match scores, a generating function of the spectrum is computed to determine the number of peptide reconstructions at each value of the scoring function. The generating function is then used to determine the number of candidate peptides for each match score and the probability of a peptide having a given match score to the spectrum. A spectral probability can be determined by calculating the total probability of all peptides with scores equal to or larger than the given match score.

Abstract: Systems and methods for modifying a medical model of a physical system is disclosed. One disclosed system includes a graphical user interface configured to display at least one parameter associated with the medical model and receive a modification of the at least one parameter. The system also includes a processor configured to receive the modification of the at least one parameter from the graphical user interface and execute a simulation of a part of the medical model including the modification of the at least one parameter.

Abstract: The invention is applied to an internal combustion engine in which fuel cut control is performed. The internal combustion engine has an exhaust gas recirculation system including: an exhaust gas recirculation passage that connects an intake and exhaust passage of the engine; and an exhaust gas recirculation valve that changes a cross section of the exhaust gas recirculation passage. A correlation, which holds during a predetermined period of time immediately after fuel cut control is stopped, between engine rotation speed NE and an index value indicating the amount of burned gas contained in the recirculated exhaust gas that passes through the exhaust gas recirculation valve (S101 to S104). The correlation is stored in an electronic control unit in advance (S105). Immediately after the fuel cut control is stopped, the index value indicating the burned gas amount is computed from the correlation stored in the electronic control unit based on the engine rotation speed NE.

Abstract: The present invention comprises devices, systems, methods, and computer program products for managing data related to the dispensing of contrast media as part of a medical procedure. The device and system provide a controller that is capable of communicating with a dispensing device so as to extract, arrange, process, and present a data set (e.g., a usage data set) from the dispensing device to a user such that the user may selectively monitor statistics related to the administration of contrast media, saline, or other consumables used during one or more dispensing operations. The method and computer program product for managing data related to the dispensing of contrast media may further allow for extraction, arrangement, processing, and presentation of the data set via the controller, via a user interface that is operably engaged with the dispensing device and/or via a computer network that may be in communication with the dispensing device.

Abstract: Among other things, methods, systems, apparatus for performing on-the-fly apportionment are described. In particular, spectrum data associated with a particle is acquired in real-time. The acquired real-time spectrum data is analyzing in real-time to classify the particle. Analyzing the data in real-time includes comparing the acquired spectrum data with a library of known mass spectral fingerprints to obtain a match.

Abstract: A method and device allow the determination of the concentrations of a plurality of gas species in a gas mixture based on the output signals from a plurality of gas sensors, each of which is sensitive to a plurality of gas species in the gas mixture. The method includes measuring the response of each sensor at a number of levels of each gas in the mixture, determining a mathematical representation of the response characteristics of each sensor, and using the mathematical representation to determine gas concentrations from sensor readings.

Abstract: A blood sugar condition is estimated by measuring a urine sugar value, discriminating whether it is less than a discriminating method classification boundary value, when it is less, obtaining an averaged value of measured urine sugar values during a past predetermined period of time, measured at the same time of day as the latest measurement, calculating the difference between the averaged and measured urine sugar values, when the difference is not less than a positive discriminating reference difference, discriminating as being a blood sugar value decrease, when the measured value is not less than the discriminating method classification boundary value, obtaining an averaged value of all measured values during the past predetermined period of time, calculating a ratio between the measured and averaged values, and, when the ratio is not greater than a first discriminating reference ratio, discriminating as being the blood sugar value decrease.

Abstract: A blood glucose level information processing apparatus, method and program provide blood glucose values and blood glucose value information within a period or range desired by a user without imposing cumbersome operation on the user. The apparatus, method and program provide blood glucose values and blood glucose value information within a period or desired range by acquiring blood glucose levels measured by a blood glucose level measuring device and date/time of measurement at which the blood glucose levels are measured, displaying a line graph obtained by plotting the blood glucose values within a predetermined period. A slide bar can also be provided, for example on a graph display screen image, whereupon if the slide bar is moved, only the blood glucose values corresponding to a preceding period backdating in response to the amount of movement of the slide bar are plotted on a line graph along a time series.

Abstract: Methods to determine drug hydrophobicity and to quantify changes in drug hydrophobicity that optimize drug function by means of differential scanning calorimetry of an endothermic phase transition of a base protein-based polymer, specifically of an elastic-contractile model protein, to which is attached the drug to be evaluated for its hydrophobicity in terms of the change in Gibbs free energy for hydrophobic association, ?GHA have been developed. Also described herein is the preparation of nanoparticles comprised of protein-based polymers, specifically of elastic-contractile model proteins, designed for the binding and desired release rate of a specific drug or class of drugs. Further described herein is a means of targeting the drug-laden nanoparticle to a cell by means of decorating the nanoparticle surface with a molecular entity that selectively binds to the diseased cell or disease causing organism, e.g.

Abstract: An analyzer, and a method and an apparatus for detecting liquid overflowing from a container that the analyzer comprises, are provided. The method according to the present invention for detecting liquid overflowing from a container in the analyzer, includes a step of judging that liquid is overflowing from at least one container if the difference between a standard deviation of absorbance of the liquid measured at a plurality of points of a container at time T1 and a standard deviation of absorbance of the liquid measured at a plurality of points in said container at time T2 is greater than a predetermined threshold value.

Abstract: A whole determination area of a targeted wafer is concentrically divided in a radial direction, COP density is obtained in each divided determination segment, a maximum value of the COP density is set as COP densityRADIUSMAX, a minimum value of the COP density is set as COP densityRADIUSMIN, a value computed by “(COP densityRADIUSMAX-COP densityRADIUSMIN/COP densityRADIUSMAX” is compared to a predetermined set value, and a non-crystal-induced COP and a crystal-induced COP are distinguished from each other based on a clear criterion, thereby determining the COP generation factor. Therefore, a rejected wafer in which a determination of the crystal-induced COP is made despite being the non-crystal-induced COP can be relieved, so that a wafer production yield can be enhanced.

Abstract: Methods and compositions are provided for creating a binding protein that recognizes a rationally chosen recognition sequence in which a first amino acid has been substituted for a second amino acid using site-directed mutagenesis of a member protein of a set of proteins at an identified position or positions correlated with recognition of a chosen specified target module in the recognition sequence. A system is provided for automating the storage and manipulation of the correlations between positions and types of amino acid residues in the binding protein with specific modules at specified positions in the target recognition sequence and for designing and creating proteins with novel specificities.

Abstract: A method for monitoring blood glucose (bG) levels of a diabetic user. The method may be implemented on a non-transitory computer readable medium adapted to run on a processing subsystem, the processing subsystem forming a portion of a handheld diabetes management device for monitoring the bG levels of a diabetic user and determining a correction bolus to be provided to the user. The method may comprise using a memory to store information in a plurality of different time blocks. The information may include a plurality of differing user defined health events that each include a predetermined associated percentage value set by the user by which a correction bolus calculation will be modified to account for one of an increase or a decrease in insulin associated with each one of the defined health events. The processing subsystem may be used to communicate with the memory and to obtain the information and to calculate therefrom the correction bolus.

Abstract: Disclosed is number coding of pairs (“doublets”) or small sets (“multiplets”) of solid phase carriers which provides distinguishable subtypes of a given type of such carriers, where each carrier type is distinguishable on the bases of a different code. Such number coding is useful for augmenting a coding system, such as a color code, and thereby effectively multiplying the number of “colors” (distinguishable sub-types). It can be applied, for example, to determine whether a sample is homozygous or heterozygous at a number of different sites for one of two different alleles, where the same color code is applied for each of the two alleles, and the alleles with the same color code are distinguished by knowing how many carriers are associated with molecules which detect each different allele.

Abstract: Embodiments of the invention provide an advanced control system for steam hydrocarbon reformer furnaces, especially steam methane reformer furnaces. As described herein, the advanced control system may improve the control quality and efficiency of adjusting steam hydrocarbon reformer furnaces operating coefficients. As a result, the steam hydrocarbon reformer furnace operations become more stable, resulting in energy savings and improved furnace yield.

Abstract: A diagnostic Electrochemical Impedance Spectroscopy (EIS) procedure is applied to measure values of impedance-related parameters for one or more sensing electrodes. The parameters may include real impedance, imaginary impedance, impedance magnitude, and/or phase angle. The measured values of the impedance-related parameters are then used in performing sensor diagnostics, calculating a highly-reliable fused sensor glucose value based on signals from a plurality of redundant sensing electrodes, calibrating sensors, detecting interferents within close proximity of one or more sensing electrodes, and testing surface area characteristics of electroplated electrodes. Advantageously, impedance-related parameters can be defined that are substantially glucose-independent over specific ranges of frequencies. An Application Specific Integrated Circuit (ASIC) enables implementation of the EIS-based diagnostics, fusion algorithms, and other processes based on measurement of EIS-based parameters.

Abstract: A device for evaluating a scale inhibitor for a circulating cooling water system, the device including: an open vessel, the open vessel including a first fixing hole, a second fixing hole, and at least one test hole; a stirrer; a test piece; a condenser; and a constant temperature heater. The open vessel is disposed inside the constant temperature heater. The first fixing hole is used to fix the stirrer. The second fixing hole is used to fix the condenser. The test hole is used to fix the test piece.

Abstract: An apparatus for optimizing a patient's insulin dosage regimen over time, comprising: at least a first computer-readable memory for storing data inputs corresponding at least to one or more components in a patient's present insulin dosage regimen and the patient's blood-glucose-level measurements determined at a plurality of times; a processor operatively connected to the at least first computer-readable memory, the processor programmed at least to determine from the data inputs corresponding to the patient's blood-glucose-level measurements determined at a plurality of times whether and by how much to vary at least one of the one or more components of the patient's present insulin dosage regimen in order to maintain the patient's future blood-glucose-level measurements within a predefined range; and a display operative to display information corresponding to at least the patient's present insulin dosage regimen.

Abstract: Systems and methods for software-reconfigurable chemical process systems useful in a wide range of applications. Embodiments may include software control of internal processes, automated provisions for cleaning internal elements with solvents, provisions for clearing and drying gasses, and multitasking operation. In one family of embodiments, a flexible software-reconfigurable multipurpose reusable “Lab-on-a-Chip” or “embedded chemical processor” is realized that can facilitate a wide range of applications, instruments, and appliances. Through use of a general architecture, a single design can be economically manufactured in large scale and readily adapted to diverse specialized applications. Clearing and cleaning provisions may be used to facilitate reuse of the device, or may be used for decontamination prior to recycling or non-reclaimed disposal.

Abstract: Biomarkers that are diagnostic of type 1 diabetes, type 2 diabetes and/or diabetic disorder are identified. Detection of different biomarkers of the invention are also diagnostic of the degree of severity of type 1 diabetes, type 2 diabetes and/or diabetic disorder. An analysis includes the parameters of matching for BMI and Tanner stage. Receiver-operator characteristic (ROC) curves were established to assess association of the biomarkers with a disease.

Abstract: The present invention relates to a method of pooling samples to be analyzed for a categorical variable, wherein the analysis involves a quantitative measurement of an analyte, said method of pooling samples comprising providing a pool of n samples wherein the amount of individual samples in the pool is such that the analytes in the samples are present in a molar ratio of x0:x1:x2:x(n?1), and wherein x is equal to a positive value other than 1 representing the pooling factor.

Abstract: A universal microelectromechanical (MEMS) nano-sensor platform having a substrate and conductive layer deposited in a pattern on the surface to make several devices at the same time, a patterned insulation layer, wherein the insulation layer is configured to expose one or more portions of the conductive layer, and one or more functionalization layers deposited on the exposed portions of the conductive layer to make multiple sensing capability on a single MEMS fabricated device. The functionalization layers are adapted to provide one or more transducer sensor classes selected from the group consisting of: radiant, electrochemical, electronic, mechanical, magnetic, and thermal sensors for chemical and physical variables and producing more than one type of sensor for one or more significant parameters that need to be monitored.

Abstract: A method of analysing gas chromatography data is described. The method, a first response factor data set acquired from a gas chromatograph (GC) apparatus during a procedure on a calibration or reference gas sample at a first time is received. One or more additional response factor data sets acquired from the gas chromatograph apparatus during a procedure on a calibration or reference gas sample from one or more later times are received. The method comprises calculating a measure of uncertainty for at least one compound of the reference gas sample from the first and additional response factor data sets. The one or more later times are during an operational period of the gas chromatograph apparatus. The measure of uncertainty may be used to, for example, identify the necessity to perform a maintenance action in the GC or to assess whether the GC is in a healthy or unhealthy condition.

Abstract: When a problematic reagent is identified while operating an automatic analyzer, it is required to have a plurality of screens displayed, and it is difficult for inexperienced operators to identify a problematic position of a reagent. With the present invention, control information for reagents and a calibrator required for analysis with an automatic analyzer are displayed concurrently, so that all necessary information can be referred to one screen. In the automatic analyzer according to the present invention, screen switching as required in the conventional technology is not necessary, and improved operability and visibility are provided.

Abstract: A modular system and method for testing and measuring various physical and chemical properties of substances includes a user interface unit having a micro controller, a power source, a display, and an input device; and a sensing module having a sensor probe, a signal conditioner, and a sensor controller. The user interface unit and the sensing modules are in electrical communication with one another such that sensor data generated by the one or more sensor probes, corresponding to one or more properties of the substances, is transmitted to the micro controller of the user interface unit. The user interface unit can be used to remotely view, test, record, and analyze data obtained by the sensing module, which module may be located at a remote location. The user interface unit and the sensing module may be in wired or wireless communication according to various known wired and wireless connection means.

Abstract: An Anti-Terrorism water quality monitoring system for continuously monitoring a potable water treatment system and related potable water distribution network that provides potable water to a municipality, city, housing development or other potable water consumer. The system includes the collection of data from the water distribution system and from the water treatment facility and from advanced separation processes which are integrated into analytical instruments. The data collected are stored in a remote database on a remote server computer or bank of computers and accessible by Homeland Security or its designated agency. Preferred parameters of monitoring include the turbidity and disinfectant such as chlorine, hypochlorous acid, sodium hypochlorite, calcium hypochloritc, ozone, chlorine dioxide, chloramines, hydrogen peroxide, peracetic acid.

Abstract: Methods of compiling a database of images of plant species and the use of the database to identify unknown plant species are described. Images of the apical complexes of the plant are obtained and stored in a database to allow a comparison of the apical complexes with unknown plant species. The invention provides a facile method for the identification of unknown or unidentified plant species.

Abstract: Embodiments of the present invention are directed to determining the spatial extent, aggressiveness, and other characteristics of various types of tumors, including glioma tumors that occur in brain tissue. Various embodiments of the present invention use parameterized computational models to characterize tumor growth and employ medical imaging technologies to generate images and other types of data from which values of parameters of the computational models are derived. Having obtained the parameters for a particular tumor, the extent of the tumor is estimated, with high accuracy, and other characteristics of the tumor are derived from the parameterized computational models.

Abstract: The present invention is directed to methods and systems for applications relating to correction of numerical data resulting from dynamic changes to a true value. Such methods and systems may be used in accurate and unbiased quantitative polymerase chain reaction measurement.

Abstract: An ECU operates a charging unit such that a power storage device is charged by an electric power from a power supply. When a vehicle moves while charging the unit charges the power storage device, the ECU stops charging the unit to discontinue the charging of the power storage device. The ECU diagnoses a state of the charging unit after the charging of the power storage device is stopped. The ECU determines whether the charging of the power storage device is able to be resumed based on the diagnostic result. When determining that the charging of the power storage device is able to be resumed, the ECU resumes the charging of the power storage device by resuming the operation of the charging unit.

Abstract: The method provides for the fitting of a different distribution to the tail of a distribution of continuous data, than that distribution fitting to the rest of the distribution. By fitting a distribution to this set of occurrences only, better distributions shapes are obtained for that part of a distribution which might otherwise be overly sensitive to individual or small numbers of occurrences. Over sensitivity can make such distributions unreliable in situations where their value is compared with the value of another distribution. A distribution which does not decline quickly to zero is preferred for the tail, for instance a heavy tailed distribution.