Bacteria Or Actinomycetales; Media Therefor Patents (Class 435/252.1)
Rhizobium or agrobacterium (Class 435/252.2)
Transformants (e.g., recombinant dna or vector or foreign or exogenous gene containing, fused bacteria, etc.) (Class 435/252.3)
Mixed culture (Class 435/252.4)
Bacillus (e.g., b. subtilis, b. thuringiensis, etc.) (Class 435/252.5)
Actinoplanes (Class 435/252.6)
Clostridium (Class 435/252.7)
Escherichia (e.g., e. coli, etc.) or salmonella (Class 435/252.8)
Lactobacillus, pediococcus, or leuconostoc (Class 435/252.9)
Mycobacterium (Class 435/253.1)
Nocardia (Class 435/253.2)
Pseudomonas (Class 435/253.3)
Streptococcus (Class 435/253.4)
Streptomyces (Class 435/253.5)
Culture media, per se (Class 435/253.6)
  • Expanding the eukaryotic genetic code
    Patent number: 8114628
    Abstract: This invention provides compositions and methods for producing translational components that expand the number of genetically encoded amino acids in eukaryotic cells. The components include orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, orthogonal pairs of tRNAs/synthetases and unnatural amino acids. Proteins and methods of producing proteins with unnatural amino acids in eukaryotic cells are also provided.
    Type: Grant
    Filed: October 26, 2007
    Date of Patent: February 14, 2012
    Assignee: The Scripps Research Institute
    Inventors: Jason W. Chin, T. Ashton Cropp, J. Christopher Anderson, Peter G. Schultz
  • Method and micro-organism for treating waste water
    Patent number: 8114292
    Abstract: The invention concerns a novel isolated microorganism characterized in that it is capable of: i) transforming Kjeldahl nitrogen, ammonia nitrogen and/or nitrogen oxides into gas nitrogen; and ii) transforming carbonaceous matter into carbon dioxide; both transformation processes being carried out in aerobic condition. The invention also concerns a method for treating wastewater using said microorganism.
    Type: Grant
    Filed: April 20, 2007
    Date of Patent: February 14, 2012
    Assignee: Eco Solution
    Inventor: Alexandre Da Costa
  • E-ict-VL33 strain, vaccines thereof, and a method for protecting fishes using said vaccines
    Patent number: 8114411
    Abstract: A novel Edwardsiella ictaluri E-ict-VL33 strain, a vaccine derived from the novel Edwardsiella ictaluri E-ict-VL33 strain, especially in immersion form and oral form, and a method for protecting fishes from the infection of Edwardsiella ictaluri, especially catfish, the method including a primary immersion immunization using immersion vaccine, and after an appropriate period, boosting by oral vaccination, resulting in a strong and long-lasting immunity for fishes.
    Type: Grant
    Filed: March 17, 2011
    Date of Patent: February 14, 2012
    Assignee: Schweitzer Biotech Company Ltd.
    Inventors: Tsun-Yung Kuo, Hsu Chung Gabriel Chen
  • Antimicrobial protein compositions and production thereof from marine bacteria
    Patent number: 8114657
    Abstract: Several bacterial species were isolated from marine segment obtained from seabed sediment at depths exceeding 1700 feet. At least four of the bacteria produced a compound that showed antibacterial activity against one or more multiple-drug-resistant (MDR) bacteria isolated from hospitals and clinics. One isolate, SJCH-12, exhibited a broad range of activity against MDR strains tested, including methicillin resistant Staphylococcus aureus (MRSA).
    Type: Grant
    Filed: August 24, 2009
    Date of Patent: February 14, 2012
    Assignee: St. Joseph' Children' Hospital
    Inventors: Michael Lawman, Selena Braccili, Shabnam Eidizadeh
  • MICROORGANISM CONCENTRATION PROCESS AND DEVICE
    Publication number: 20120034621
    Abstract: A process for capturing or concentrating microorganisms for detection or assay comprises (a) providing a concentration device comprising a sintered porous polymer matrix comprising at least one concentration agent that comprises an amorphous metal silicate and that has a surface composition having a metal atom to silicon atom ratio of less than or equal to 0.5, as determined by X-ray photoelectron spectroscopy (XPS); (b) providing a sample comprising at least one microorganism strain; and (c) contacting the concentration device with the sample such that at least a portion of the at least one microorganism strain is bound to or captured by the concentration device.
    Type: Application
    Filed: March 22, 2010
    Publication date: February 9, 2012
    Inventors: Manjiri T. Kshirsagar, Andrew W. Rabins
  • MICROORGANISM AND METHOD FOR PRODUCING CANTHAXANTHIN
    Publication number: 20120034649
    Abstract: A carotenoid producing bacterium belonging to the genus Paracoccus that selectively produces canthaxanthin so that the amount thereof is not less than 90 percent by weight of the total amount of produced carotenoids including ?-carotene, ?-cryptoxanthin, echinenone, canthaxanthin, 3-hydroxyechinenone, 3?-hydroxyechinenone, zeaxanthin, phoenicoxanthin, adonixanthin, and astaxanthin. A method for producing canthaxanthin by culturing the above bacterium, and then collecting carotenoids from bacterial cells or a culture solution after the culturing.
    Type: Application
    Filed: August 10, 2011
    Publication date: February 9, 2012
    Applicant: TOSOH CORPORATION
    Inventors: Toru TANAKA, Teruhiko Ide
  • MICROORGANISM CULTURE DEVICE AND METHOD OF OPERATION THEREOF
    Publication number: 20120034677
    Abstract: The invention is directed to a microorganism culture device (100), such as a micro fluidic cell culture device. The device comprises an open chamber (10), wherein microorganisms are likely to be deposited within a liquid for subsequent study. The open chamber simplifies the deposition of the microorganisms. The chamber is further provided with retention features (11), whereby microorganisms can be retained therein. In addition, the device comprises an overflow area (20), wherein capillary structures (22) are configured to retain excess liquid overflowing from the open chamber, e.g. when covering the device with a cover. As such, it allows for confining microorganism in the chamber, while excess fluid is captured externally, e.g. to seal the device with a cover.
    Type: Application
    Filed: March 4, 2010
    Publication date: February 9, 2012
    Applicant: New Orchard Road
    Inventors: Emmanuel Delamarche, Robert Lovchik
  • T-Cell Receptor Antibodies And Methods of Use Thereof
    Publication number: 20120034221
    Abstract: The present invention is directed to the production and use of monoclonal antibodies, or antigen binding fragments thereof, that specifically bind the T cell antigen receptor (TCR) and their use for immunomodulation. In preferred embodiments, the antibody or antigen binding fragment of the invention specifically binds the constant region of the ? chain of the TCR, or otherwise specifically binds the ? chain regardless of TCR clonal origin (i.e., is pan specific for TCR). The antibodies of the invention may be used, for example, in immunosuppressive therapies for transplant maintenance and the treatment of autoimmune diseases, and/or as targeting molecules for use in the treatment of T-cell malignancies.
    Type: Application
    Filed: October 14, 2011
    Publication date: February 9, 2012
    Applicant: MACROGENICS INC.
    Inventors: Ezio Bonvini, Leslie S. Johnson, Nadine Tuaillon, Ling Huang
  • VEGFR-1/NRP-1 TARGETING PEPTIDES
    Publication number: 20120028880
    Abstract: The present invention concerns the fields of molecular medicine and targeted delivery of therapeutic agents. More specifically, the present invention relates to the identification of novel peptide sequences that incorporate the amino acids Leu-Pro-Arg (LPR), and particularly D(LPR), that selectively target VEGFR-I and NRP-I expressing cells. Targeted molecules in accor-dance with the invention are useful in the treatment and detection of neovascular or angiogenic VEGF associated disorders, including but not limited to cancer, obesity, diabetes, asthma, arthritis, cirrhosis and ocular diseases.
    Type: Application
    Filed: August 8, 2008
    Publication date: February 2, 2012
    Inventors: Renata Pasqualini, Wadih Arap, Ricardo Giordano, Marina Cardó-Vila, Ana Paula Valente, Fabio Ceneviva Lacerda De Almeida
  • TRANSFECTION WITH MICRO EXPLOSION ENACTED BY COATED DRY ICE PARTICLES
    Publication number: 20120028356
    Abstract: Disclosed is a transfection method, which includes the steps of: (a) adhering the gene fragments to dry ice particles; (b) adding the dry ice particles into the medium/liquid that contains target cells; and (c) transporting the gene fragments into the target cells via the micro explosion/sublimation of the dry ice particles. In addition, the gene fragments can also adhere first to nanoparticles, which can then adhere to dry ice particles. Subsequently, gene fragments enter cells by micro explosion/sublimation. The present invention can be applied in transgenic research on prokaryotic, eukaryotic, plant and animal cells and in the development of new species in agriculture.
    Type: Application
    Filed: November 30, 2010
    Publication date: February 2, 2012
    Applicant: NATIONAL YANG MING UNIVERSITY
    Inventors: Fu-Jen KAO, Yung-En Kuo
  • Sorting Chamber
    Publication number: 20120028349
    Abstract: A sorting chamber (1) for sorting first particles (25) from second particles (26) comprising: an internal chamber (7), which is delimited by a base wall (2), a top wall (4), and a spacer (6), set between the base wall (2) and the top wall (4); an internal chamber (7), which is at least partially-delimited by the base wall (2) and top wall (4); two passages (8), which set in communication the internal chamber (7) with the external environment; and a plurality of cavities (9), which are designed to house the first particles (25), are made in the base wall (2) and have openings (10) towards the internal chamber (7) with widths of from 4 to 6 ?m.
    Type: Application
    Filed: October 1, 2009
    Publication date: February 2, 2012
    Applicant: SILICON BIOSYSTEMS S.P.A.
    Inventors: Giuseppe Giorgini, Gerardo Perozziello, Alex Calanca, Gianni Medoro, Nicolò Manaresi
  • Nucleotide and amino acid sequences relating to respiratory diseases and obesity
    Patent number: 8105826
    Abstract: This invention relates to genes identified from human chromosome 12q23-qter, which are associated with various diseases, including asthma. The invention also relates to the nucleotide sequences of these genes, isolated nucleic acids comprising these nucleotide sequences, and isolated polypeptides or peptides encoded thereby. The invention further relates to vectors and host cells comprising the disclosed nucleotide sequences, or fragments thereof, as well as antibodies that bind to the encoded polypeptides or peptides. Also related are ligands that modulate the activity of the disclosed genes or gene products. In addition, the invention relates to methods and compositions employing the disclosed nucleic acids, polypeptides or peptides, antibodies, and/or ligands for use in diagnostics and therapeutics for asthma and other diseases.
    Type: Grant
    Filed: March 23, 2007
    Date of Patent: January 31, 2012
    Assignee: Oscient Pharmaceuticals Corporation
    Inventors: Tim Keith, Randall D. Little, Paul Van Eerdewegh, Josée Dupuis, Richard G. Del Mastro, Jason Simon, Kristina Allen, Sunil D. Pandit
  • Anaerobic microbial composition and methods of using same
    Patent number: 8105808
    Abstract: A microbial composition for concurrent dechlorination of a mixture of chlorinated ethanes and chlorinated ethenes includes a isolated consortium of bioremediative microorganisms comprising strains of microorganism comprising Clostridium, Acetobacterium, Dehalobacter, Bacteroides, and Proteobacteria. The composition may also include Methanomicrobia.
    Type: Grant
    Filed: June 2, 2008
    Date of Patent: January 31, 2012
    Assignee: The United States of America as represented by the Secretary of the Interior
    Inventors: Michelle M. Lorah, Elizabeth A. Jones, Mary A. Voytek
  • Fluorometric analysis kit
    Patent number: 8105829
    Abstract: Chemically reactive carbocyanine dyes that are intramolecularly crosslinked between the 1-position and 3?-position, their bioconjugates and their uses are described. 1,3?-crosslinked carbocyanines are superior to those of conjugates of spectrally similar 1,1?-crosslinked or non-crosslinked dyes. The invention includes derivative compounds having one or more benzo nitrogens.
    Type: Grant
    Filed: October 21, 2010
    Date of Patent: January 31, 2012
    Assignee: AnaSpec Incorporated
    Inventors: Zhenjun Diwu, Jianheng Zhang, Yi Tang, Xiang Guobing
  • Multiple inducible gene regulation system
    Patent number: 8105825
    Abstract: The present invention relates to the field of biotechnology or genetic engineering. More specifically, the present invention relates to a multiple inducible gene regulation system that functions within cells to simultaneously control the quantitative expression of multiple genes.
    Type: Grant
    Filed: September 27, 2001
    Date of Patent: January 31, 2012
    Assignee: Intrexon Corporation
    Inventors: Tarlochan Singh Dhadialla, Dean Ervin Cress, Glenn Richard Carlson, Robert Eugene Hormann, Subba Reddy Palli, Arthur John Kudla, Ronald Phillip Herzig, Jr., Mohan Philip
  • Method of producing a low molecular weight organic compound in a cell
    Patent number: 8105786
    Abstract: A method of producing a low molecular weight organic compound (e.g. a plant or bacteria secondary metabolite) in increased yields involving use of a microorganism cell, which comprises a gene involved in the biosynthesis pathway leading to a low molecular weight organic aglycon compound and a glycosyltransferase gene capable of glycosylating the produced aglycon.
    Type: Grant
    Filed: October 21, 2010
    Date of Patent: January 31, 2012
    Assignee: Evolva SA
    Inventors: Joergen Hansen, Thomas Hvid Andersen, Finn Thyge Okkels
  • CELLS FOR INCREASED PROTEIN EXPRESSION COMPRISING ONE OR MORE RELEASE FACTORS AND METHODS OF USE
    Publication number: 20120022232
    Abstract: The invention provides recombinant cells or recombinant restrictive cells for overexpressing one or more proteins comprising one or more release factors. The invention also provides methods for producing a recombinant protein comprising culturing the cells of the present invention under conditions such that one or more proteins are overexpressed, and then isolating the expressed recombinant protein, In certain embodiments of the present invention, the gene encoding the protein is codon optimized.
    Type: Application
    Filed: December 2, 2009
    Publication date: January 26, 2012
    Applicant: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Rachel Green, Hani S. Zaher
  • Microorganisms of Corynebacterium with Improved 5'-Inosinic Acid Productivity, and Method for Producing Nucleic Acids Using Same
    Publication number: 20120021466
    Abstract: The present invention relates to a microorganisms of the genus Corynebacterium producing 5?-inosinic acid, in which the expression of genes encoding purine biosynthesis related enzymes is increased higher than the intrinsic expression, and to a method for producing 5?-inosinic acid, comprising culturing the microorganisms of the genus Corynebacterium with improved 5?-inosinic acid productivity.
    Type: Application
    Filed: March 23, 2010
    Publication date: January 26, 2012
    Applicant: CJ CHEILJEDANG CORPORATION
    Inventors: Jeong Hwan Kim, Jung Gun Kwon, Tae Min Ahn, Soo Youn Hwang, Min Ji Baek, Na Ra Kwon, Nan Young Yoon, Ju Jeong Kim
  • BIOREACTOR AND USES THEREOF
    Publication number: 20120021507
    Abstract: Disclosed are bioreactor systems and methods to transfer a gaseous composition into a liquid composition in a closed environment. Also disclosed are bioreactor systems and methods for high-density culture of microorganisms and stably culture of activated sludge.
    Type: Application
    Filed: January 20, 2010
    Publication date: January 26, 2012
    Inventor: Mizhou Hui
  • MYCOPLASMA GALLISEPTICUM FORMULATION
    Publication number: 20120021005
    Abstract: The present invention provides a formulation that prevents virulent Mycoplasma galHsepticum infection in birds of the order GaIHf ormes. The formulation comprises live Mycoplasma galHsepticum strain K5831 or derivatives thereof in a pharmaceutically acceptable carrier. A vaccine that prevents virulent Mycoplasma galHsepticum infection in birds of the order Galliformes is also presented. Methods for administering the formulation and vaccine are also presented.
    Type: Application
    Filed: January 22, 2010
    Publication date: January 26, 2012
    Applicant: University of Georgia Research Foundation, Inc.
    Inventors: Stanley H. Kleven, Naola M. Ferguson
  • Belt Agitation System For Culture Bottles
    Publication number: 20120021452
    Abstract: A specimen culture container agitation assembly includes an endless belt having a multitude of container-receiving clips attached thereto, each of which is adapted for retaining a specimen culture container to the belt. The belt is oriented vertically. The assembly further includes upper and lower pulleys over which the belt is driven. A drive motor drives the belt around the pulleys. Agitation of the specimen culture container is achieved by rotation of the belt over the pulleys and the retaining of the specimen culture container by the clip.
    Type: Application
    Filed: July 21, 2011
    Publication date: January 26, 2012
    Applicant: BIOMERIEUX, INC.
    Inventor: James C. Bishop
  • GENERATION OF MATERIALS WITH ENHANCED HYDROGEN CONTENT FROM ANAEROBIC MICROBIAL CONSORTIA INCLUDING DESULFUROMONAS OR CLOSTRIDIA
    Publication number: 20120021495
    Abstract: An isolated microbial consortia is described. The consortia may include a first-bite microbial consortium that converts a starting hydrocarbon that is a complex hydrocarbon into two or more first-bite metabolic products. The consortia may also include a downstream microbial consortium that converts a starting hydrocarbon metabolic product into a downstream metabolic product. The downstream metabolic product has a greater mol. % hydrogen than the starting hydrocarbon. The first-bite microbial consortium or the downstream microbial consortium includes one or more species of Desulfuromonas.
    Type: Application
    Filed: July 22, 2011
    Publication date: January 26, 2012
    Applicant: LUCA Technologies, LLC
    Inventor: Gary Vanzin
  • ORGANIC BIOFILM SUBSTRATA AS A MICROBIAL INOCULUM DELIVERY VEHICLE FOR BIOAUGMENTATION OF PERSISTENT ORGANIC POLLUTANTS IN CONTAMINATED SEDIMENTS AND SOILS
    Publication number: 20120021493
    Abstract: A system and methods for removal of persistent organic pollutants (POPs) from an environment, where the system includes an inert and organic biofilm substrata as biofilm media for dual use: 1) inoculation of microorganisms to degrade POPs and 2) accumulation of POPs on the substrata, effective in maintaining bioavailable concentrations for sustaining microbial activity. Microorganisms capable of degrading or transforming POPs are actively associated with the substrata as a biofilm. Application of this delivery vehicle will enhance the microbial degradation of POPs, while simultaneously adsorbing hydrophobic POPs from the environment making them bioavailable for the microorganisms located in the formed biofilms and additionally lowering the aqueous concentration of POPs that have detrimental effects towards fish and mammals as they bioaccumulate through the food chain.
    Type: Application
    Filed: July 6, 2011
    Publication date: January 26, 2012
    Applicant: UNIVERSITY OF MARYLAND BALTIMORE COUNTY
    Inventors: Kevin R. Sowers, Birthe Kjellerup, Upal Ghosh
  • Bacterial Strains Having an Outstanding Ability to Produce Menaquinone
    Publication number: 20120020927
    Abstract: The invention relates to bacterial strains having an outstanding ability to produce menaquinone and to applications thereof.
    Type: Application
    Filed: April 15, 2010
    Publication date: January 26, 2012
    Applicant: DANISCO A/S
    Inventors: Pascal Fourcassie, Patrick Boyaval, Philippe Horvath
  • ENHANCED PHOTOSYNTHESIS AND PHOTOCATALYSIS WATER TREATMENT/BIOMASS GROWTH PROCESS
    Publication number: 20120021494
    Abstract: A process utilizing enhanced photosynthesis and photocatalysis to purify water and/or utilize CO2 on a large scale by growing biomass in reduced time and space in a closed, continuous-flow system. Added CO2 and balanced nutrients combine with light to increase the growth rate of autotrophic microalgae which require CO2 for growth and produce oxygen. Organic and inorganic compounds and chemical toxins are mineralized in photocatalysis using such produced oxygen, which are then absorbed (metabolized) in the microalgal biomass that is harvested.
    Type: Application
    Filed: July 13, 2011
    Publication date: January 26, 2012
    Applicant: Krebs & Sisier L.P.
    Inventor: William P. Krebs
  • Cultivation and dispensing of bacteria
    Publication number: 20120021492
    Abstract: An apparatus 100 for cultivating bacteria, comprising a conduit 101 having an upstream and a downstream section and the downstream section of the conduit 101 comprising first Venturi eductor means 111 with at least two inlet ports 117, 118 wherein one of said inlet ports 117 is in fluid communication with a supply of nutrient and another one of said inlet ports 118 is in fluid communication with a supply of bacteria such that, in use, nutrient and bacteria are drawn into said Venturi eductor means 111 by a fluid passing along said conduit 101 and said Venturi eductor means 111.
    Type: Application
    Filed: May 6, 2011
    Publication date: January 26, 2012
    Inventors: David Fielding, Chris Dyer
  • Methods and compositions for the recombinant biosynthesis of -alkanes
    Patent number: 8101397
    Abstract: The present disclosure identifies methods and compositions for modifying photoautotrophic organisms as hosts, such that the organisms efficiently convert carbon dioxide and light into n-alkanes, and in particular the use of such organisms for the commercial production of n-alkanes and related molecules.
    Type: Grant
    Filed: March 18, 2011
    Date of Patent: January 24, 2012
    Assignee: Joule Unlimited Technologies, Inc.
    Inventors: Nikos Basil Reppas, Christian Perry Ridley
  • Probiotic health or fitness promoting human or animal foodstuff and/or drinking water additive and use thereof
    Patent number: 8101170
    Abstract: The invention relates to a probiotic health or fitness promoting human or animal foodstuff and/or drinking water additive, comprising a mixture of microorganisms, selected from the group Enterococcus faecium, DSM 16211, Lactobacillus reuteri, DSM 16350, Lactobacillus salivarius ssp. salivarius, DSM 16351, Pediococcus acidilactici, DSM 16210, Bifidobacterium animalis and DSM 16284. The invention further relates to a use of the human or animal foodstuff and/or drinking water additive, in particular for prevention of the harmful effect of a number of undesirable germs in the digestive system of animals and/or domestic birds.
    Type: Grant
    Filed: June 14, 2006
    Date of Patent: January 24, 2012
    Assignee: Erber Aktiengesellschaft
    Inventors: Regina Plail, Gerd Schatzmayr, Eva Maria Binder, Michaela Mohnl, Alfred Klimitsch, Sabine Nitsch, Viviana Klose
  • Minicells displaying antibodies or derivatives thereof and comprising biologically active compounds
    Patent number: 8101396
    Abstract: Minicells are used to deliver biologically active compounds including radioisotopes, polypeptides, nucleic acids, small molecules, drug molecules, and chemotherapeutic agents. In some cases, the minicell displays ligands or binding moieties that target the minicell to a desired host cell.
    Type: Grant
    Filed: March 16, 2007
    Date of Patent: January 24, 2012
    Assignee: Vaxiion Therapeutics, Inc.
    Inventors: Roger A. Sabbadini, Neil Berkley, Mark W. Surber, Robert Klepper
  • Artemisinic epoxide and methods for producing same
    Patent number: 8101399
    Abstract: The present invention provides artemisinic epoxide, and methods of synthesizing artemisinic epoxide in a genetically modified host cell. The present invention further provides methods for producing artemisinin. The present invention further provides variant enzymes that catalyze the oxidation of amorpha-4,11-diene to artemisinic epoxide; nucleic acids encoding the variant enzymes; as well as recombinant vectors and host cells comprising the nucleic acids.
    Type: Grant
    Filed: December 12, 2007
    Date of Patent: January 24, 2012
    Assignee: The Regents of the University of California
    Inventors: Jeffrey Allen Dietrich, Yasuo Yoshikuni, Jay D. Keasling, Michelle Chia-Yu Chang
  • HYPOGLYCEMIC EFFECT ENHANCER
    Publication number: 20120014923
    Abstract: A hypoglycemic effect enhancer for enhancing the activity of an ?-glucosidase inhibitor, the enhancer comprising at least one kind of bacteria selected from the group consisting of bifidobacteria, lactic acid bacteria, saccharifying bacteria, and butyric acid bacteria.
    Type: Application
    Filed: March 25, 2010
    Publication date: January 19, 2012
    Inventors: Yasuhiro Isa, Masaki Shimakawa, Hiroshi Ohno, Hideki Yamamura
  • BACTERIA FOR HIGH EFFICIENCY CLONING
    Publication number: 20120015426
    Abstract: Disclosed are novel bacterial hosts that are capable of high efficiency transformation with methylated and/or unmethylated nucleic acids, and that are bacteriophage resistant. Such bacteria contain: (1) an F? episome that confers high efficiency transformability; (2) one or more mutations that allow transformation of methylated nucleic acids; (3) one or more mutations that allow transformation with unmethylated nucleic acids; and/or (4) one or more mutations that confer resistance to bacteriophage infection. Also disclosed are methods for transforming such bacteria, and kits that contain such bacteria (e.g., that have been made competent for transformation).
    Type: Application
    Filed: September 27, 2011
    Publication date: January 19, 2012
    Applicant: LIFE TECHNOLOGIES CORPORATION
    Inventors: Fredric R. BLOOM, Brian Schmidt
  • Delivery vehicle for probiotic bacteria comprising a dry matrix of polysaccharides, saccharides and polyols in a glass form and methods of making same
    Patent number: 8097245
    Abstract: The disclosure relates to a solid glass matrix of polysaccharide, saccharides and polyols as delivery vehicle for preservation and post gastric administration of a probiotic. The delivery vehicle is capable of releasing the probiotic at their site of action. The present invention further includes methods of making and using the solid glass matrix delivery vehicle of the invention.
    Type: Grant
    Filed: December 28, 2006
    Date of Patent: January 17, 2012
    Assignee: Advanced Bionutrition Corporation
    Inventors: Mordechi Harel, Keren Kohavi-Beck
  • MICROORGANISM CONCENTRATION PROCESS AND DEVICE
    Publication number: 20120009569
    Abstract: A process for capturing or concentrating microorganisms for detection or assay comprises (a) providing a concentration device comprising a sintered porous polymer matrix comprising at least one concentration agent that comprises diatomaceous earth bearing, on at least a portion of its surface, a surface treatment comprising a surface modifier comprising ferric oxide, titanium dioxide, fine-nanoscale gold or platinum, or a combination thereof; (b) providing a sample comprising at least one microorganism strain; and (c) contacting the concentration device with the sample such that at least a portion of the at least one microorganism strain is bound to or captured by the concentration device.
    Type: Application
    Filed: March 22, 2010
    Publication date: January 12, 2012
    Inventors: Manjiri T. Kshirsagar, Andrew W. Rabins
  • Use of polypeptides having antimicrobial activity
    Patent number: 8092810
    Abstract: The present invention relates to the use of polypeptides related to a Bacillus licheniformis polypeptide (amino acids 1-85 of SEQ ID NO: 2) as antimicrobial agents, for example in pharmaceutical applications, including veterinary applications, as well as for preservation, cleaning and disinfection of various surfaces, objects and substances. The polypeptides may in particular be used to treat textiles or laundry, e.g., in detergents, for reducing microbes on textile or laundry, and/or for odor reduction. The invention also relates to use of Bacillus strains producing these polypeptides as antimicrobial agents. Examples of microorganism inhibited by Lento are Gram positive bacterial strains, such as Bacillus cereus, and various species of Corynebacterium, Enterococcus, Micrococcus, Streptococcus, and Staphylococcus.
    Type: Grant
    Filed: December 16, 2010
    Date of Patent: January 10, 2012
    Assignee: Novozymes A/S
    Inventor: Debbie Yaver
  • Ovo vaccination of in avian species
    Patent number: 8092808
    Abstract: The present invention provides a method of inducing an immune response against Campylobacter in an avian species, especially a domesticated avian species such as chicken, turkey, duck, goose and quail, by administering, in ovo, live cells of Campylobacter.
    Type: Grant
    Filed: November 22, 2004
    Date of Patent: January 10, 2012
    Assignee: Pfizer, Inc.
    Inventors: Tonia Sue Agin, Everett L. Rosey, Frederick H. Weber
  • METHOD FOR MAKING LACTIC ACID BACTERIA COMPOSITION
    Publication number: 20120003721
    Abstract: A method for making at least 2 kg (dry weight) of a lactic acid bacteria composition formulated with from 1% to 50% of ascorbate or ascorbic acid (w/w?dry matter) as antioxidant, wherein the pH is controlled so 3?pH?8 during at least the majority of the fermentation process by addition of a base not comprising NH3 (ammonia).
    Type: Application
    Filed: February 18, 2010
    Publication date: January 5, 2012
    Inventors: Birgitte Yde, Susanne Abrahamsen
  • ELECTROPORATION APPARATUS AND METHODS
    Publication number: 20120003740
    Abstract: This document discloses electroporation vessels, electrocompetent cells that have been aliquoted and frozen in electroporation vessels, and a number of other apparatuses, kits, and methods for electroporation. Some embodiments of electroporation vessels described herein may include a pair of opposing walls that are downwardly angled toward one another in a gap between two electrode surfaces. Further embodiments of devices and methods described herein may eliminate the need for an end user to transfer competent cells from a capped tube to electroporation cuvette, thereby saving time and producing less waste.
    Type: Application
    Filed: December 28, 2010
    Publication date: January 5, 2012
    Applicant: LIFE TECHNOLOGIES CORPORATION
    Inventors: Laura Vozza-Brown, Harry Yim, John Cameron, Matthew O'Banion, Adam Scott Henry, Lisa Marie Olivier
  • Process for the Production of Fine Chemicals
    Publication number: 20120005777
    Abstract: The present invention relates to a process for the production of fine chemicals in a microorganism, a plant cell, a plant, a plant tissue or parts thereof. The invention furthermore relates to nucleic acid molecules, polypeptides, nucleic acid constructs, vectors, antisense molecules, antibodies, host cells, plant tissue, propagtion material, harvested material, plants, microorganisms as well as agricultural compositions and to their use.
    Type: Application
    Filed: July 12, 2011
    Publication date: January 5, 2012
    Applicant: BASF Plant Science GmbH
    Inventors: Gunnar Plesch, Piotr Puzio, Astrid Blau, Ralf Looser, Birgit Wendel, Beate Kamlage, Agnes Chardonnens, Amber Shirley, Xi-Qing Wang, Rodrigo Sarria-Millan, Bryan McKersie, Ruoying Chen
  • SAMPLING DEVICES AND METHODS FOR CONCENTRATING MICROORGANISMS
    Publication number: 20120003626
    Abstract: The present disclosure describes methods for concentrating microorganisms with concentration agents in a sampling device and the sampling device described herein. More specifically, methods for concentrating microorganisms from large volume samples with concentration agents in a sampling device can provide for rapid, low cost, simple (involving no complex equipment or procedures), and/or effective processes under a variety of conditions.
    Type: Application
    Filed: December 30, 2009
    Publication date: January 5, 2012
    Inventors: Manjiri T. Kshirsagar, Kurt J. Halverson, Neil Percy, James E. Aysta
  • Optimised micro-organism strains for NADPH-consuming biosynthetic pathways
    Patent number: 8088620
    Abstract: The invention relates to optimised micro-organism strains for the biotransformation production of molecules having NADPH-consuming biosynthetic pathways. The inventive strains can be used in NADPH-consuming biotransformation methods. Said strains are characterized in that one or more NADPH-oxidizing activities are limited.
    Type: Grant
    Filed: November 5, 2004
    Date of Patent: January 3, 2012
    Assignee: Metabolic Explorer
    Inventors: Gwénaëlle Bestel-Corre, Cédric Boisart, Michel Chateau, Benjamin Gonzalez, Philippe Soucaille, Rainer Figge, Olivier Zink
  • METHODS, KITS AND SYSTEMS FOR PROCESSING SAMPLES
    Publication number: 20110318814
    Abstract: A method for isolating microorganisms from a sample, the sample including sample matrix and microorganisms, the method including the steps of providing a receptacle, the receptacle configured to allow filtering of the sample and to reversibly contain the sample and a concentration agent; adding the sample to the receptacle, wherein a microorganism-bound composition will be formed in the receptacle, the microorganism-bound composition including concentration agent-bound microorganisms and sample matrix; and filtering the microorganism-bound composition through a filter to collect the concentration agent-bound microorganisms on the filter, wherein the filter has an average pore size that is greater than the average size of the microorganisms. Kits and systems are also disclosed herein.
    Type: Application
    Filed: December 30, 2009
    Publication date: December 29, 2011
    Inventors: Manjiri T. Kshirsagar, Kurt J. Halverson, Raj Rajagopal
  • EQUOL-PRODUCING BACTERIUM AND USE THEREOF
    Publication number: 20110318309
    Abstract: The present invention is directed to a microorganism having an ability of converting daidzein to equol in 24 hours of 50% or higher; a food/beverage or pharmaceutical composition containing the microorganism; an equol production method employing the microorganism; and a nucleic acid fragment which can specifically detect the microorganism.
    Type: Application
    Filed: February 25, 2010
    Publication date: December 29, 2011
    Applicant: KABUSHIKI KAISHA YAKULT HONSHA
    Inventors: Hirokazu Tsuji, Koji Nomoto, Kaoru Moriyama, Hideyuki Akaza
  • AGENT FOR PREVENTION OR AMELIORATION OF OBESITY
    Publication number: 20110311502
    Abstract: To provide a pharmaceutical product or food which has an excellent fat-accumulation-inhibiting activity and/or fat-metabolism-improving activity and which is effective for inhibition or improvement of obesity, fatty liver, etc. The present invention provides an agent for preventing or ameliorating obesity containing, as an active ingredient, cells of a lactic acid bacterium belonging to the genus Pediococcus, a cell culture thereof, or an extract of any of these.
    Type: Application
    Filed: February 26, 2010
    Publication date: December 22, 2011
    Applicant: HIROSHIMA UNIVERSITY
    Inventors: Masanori Sugiyama, Fumiko Higashikawa, Masafumi Noda
  • COMPOSITIONS AND METHODS FOR DEGRADING LIGNOCELLULOSIC BIOMASS
    Publication number: 20110306085
    Abstract: The present invention relates to compositions and methods of producing bioenergy products and metabolites of industrial interest from lignocellulosic biomass. More specifically, the invention describes the identification, characterization and isolation of novel bacteria having the remarkable ability to transform lignocellulosic biomass into fermentable sugars and, even more remarkably, into bioenergy products and metabolites. The invention also discloses a method to isolate such bacteria, compositions comprising such bacteria, and their uses for the modification of lignocellulosic biomass, with a view to producing bioenergy.
    Type: Application
    Filed: February 16, 2010
    Publication date: December 15, 2011
    Applicants: Centre National De La recherche Scientifique,, DEINOVE
    Inventors: Cathy Isop, Pascale Joesph, Jean-Paul Leonetti, Jacques Biton
  • HIV-1 Envelope Polypeptides for HIV Vaccine
    Publication number: 20110305749
    Abstract: Immunogenic HIV-1 envelope polypeptides are provided, wherein specific amino acid residues are mutated to repress immunosuppression in GP41, thereby boosting the immune response against HIV-1. Specifically, mutation of those specific residues does not affect the fusogenic properties of the viral particle and/or the overall protein structure of the viral envelope protein. The invention further provides peptides and antigens based on the immunogenic HIV-1 envelopes as well as nucleic acid sequences and vectors encoding those. Moreover, biological entities such as viral particles are provided, as well as use of the provided components for preparation of a vaccine against HIV-1/AIDS.
    Type: Application
    Filed: August 28, 2009
    Publication date: December 15, 2011
    Inventors: Mogens Ryttergaard Duch, Finn Skou Pedersen, Shervin Bahrami, Palle Villesen Fredsted, Carsten Wiuf, Lars Jørgen Østergaard, Martin Tolstrup
  • Environmental Remediation Material and Method of Making Same
    Publication number: 20110306115
    Abstract: An environmental remediation material and method for making the same which include processing an organic material to increase the internal surface and surface pore area thereof through pyrolysis, coating the pyrolyzed material with a non-polar substance to enhance the material's oleophilicity, and applying secondary processing treatments designed to optimize the material for preselected chemical remediation applications. The remediation material is insoluble in aqueous environments, free of environmentally hazardous chemicals or compounds and readily transportable and disposable following use.
    Type: Application
    Filed: June 14, 2011
    Publication date: December 15, 2011
    Applicant: ECI RESEARCH AND DEVELOPMENT COMPANY
    Inventors: Daniel W. Mulqueen, James L. Fournier, Thomas B. Reed
  • LANTIBIOTICS AND USES THEREOF
    Publication number: 20110305763
    Abstract: The present invention provides isolated lantibiotics that inhibit. Gram negative and Gram positive microbes. The antibiotic includes an amino acid sequence, wherein the amino acid sequence of the compound and the amino acid sequence of SEQ ID NO:21 or SEQ ID NO:22 have at least 80% identity. The lantibiotics have the characteristic of inhibiting growth of a Gram negative microbe in conditions that do not damage the outer membrane of the Gram negative microbe. The present invention also provides methods for making and using the lantibiotics.
    Type: Application
    Filed: May 3, 2011
    Publication date: December 15, 2011
    Applicant: Regents of the University of Minnesota
    Inventors: DANIEL J. O'SULLIVAN, Ju-Hoon Lee
  • THERMOPHILIC METHANOGENIC CONSORTIUM FOR CONVERSION OF CELLULOSIC BIOMASS TO BIOENERGY
    Publication number: 20110306089
    Abstract: A system for the efficient conversion of plant biomass to methane is provided, where the conversion includes use of a thermophilic methanogenic consortium containing a cellulolytic thermophile, an acetate-oxidizing thermophile and a thermophilic methanogen, the combination of which hydrolyzes hexoses and pentoses, oxidizes acetate and provides a hydrogen sink, to convert plant biomass to the theoretical limit of bioenergy.
    Type: Application
    Filed: February 14, 2011
    Publication date: December 15, 2011
    Inventors: Kevin R. Sowers, Harold D. May, Chanlan Chun, Chrisopher William Marshall
  • Transcription factor modulating compounds and methods of use thereof
    Publication number: 20110306611
    Abstract: Substituted benzoimidazole compounds useful as anti-infectives that decrease resistance, virulence, or growth of microbes are provided. Methods of making and using substituted benzoimidazole compounds, as well as pharmaceutical preparations thereof, in, e.g., reducing antibiotic resistance and inhibiting biofilms.
    Type: Application
    Filed: August 3, 2009
    Publication date: December 15, 2011
    Applicant: Paratek Pharmaceuticals, Inc.
    Inventors: Michael N. Alekshun, Victor Amoo, Oak K. Kim, Atul K. Verma