Bacteria Or Actinomycetales; Media Therefor Patents (Class 435/252.1)
  • Publication number: 20140227767
    Abstract: The invention provide isolated peptides, protides and conjugates having novel peptide sequences which are able to induce antimicrobial, anti-cancer, anti-inflammatory, anti-proliferative or programmed cell death activity. The invention also provides a method of inducing programmed cell death in a cell by contacting the cell with an isolated peptide, protide or conjugate described herein. In some aspects, the method can be used in the diagnosis, prevention, or treatment of a disease, such as an infection, cancer, autoimmune disease, or inflammatory disease.
    Type: Application
    Filed: May 1, 2013
    Publication date: August 14, 2014
    Inventors: Michael R. YEAMAN, Nannette Y. YOUNT, Eric P. BRASS
  • Publication number: 20140227229
    Abstract: The present invention relates to gram positive bacteria with increased stress resistance and/or improved storage characteristics. In particular, the invention relates to gram positive bacterium which accumulate intracellular trehalose. The gram positive bacterium according to the invention lack cellobiose-specific PTS system IIC component (PtcC) activity. The gram positive bacterium may further lack trehalose 6-phosphate phosphorylase (TrePP) activity. The gram positive bacterium may further overexpress trehalose transporters. The invention further relates to compositions comprising such gram positive bacterium as well as methods and uses thereof.
    Type: Application
    Filed: September 21, 2012
    Publication date: August 14, 2014
    Inventors: Lothar Steidler, Karolien Van Huynegem, Klaas Vandenbroucke
  • Patent number: 8802404
    Abstract: The present disclosure relates to a method for recovering a vinyl acid monomer by providing an aqueous fermentation broth which undergoes microbial fermentation of a nutrient medium containing a carbon source including at least one microorganism to produce a vinyl acid monomer. The method provides a direct overall route to bio-based polymers of the vinyl acid monomer, and in particular, polymers of polyitaconic acid.
    Type: Grant
    Filed: April 6, 2011
    Date of Patent: August 12, 2014
    Assignees: University of New Hampshire, Itaconix Corporation
    Inventors: Jennifer Durant, Yvon Durant, John Shaw
  • Patent number: 8802171
    Abstract: A live organism product wherein the organisms are in a dormant state and are suspended in a liquid carrier which is sufficiently devoid of moisture so that the organisms will remain in a dormant state for several months. The carrier is comprised of oil. The carrier may also include an absorbent. The product is stored and shipped in a plastic bag and is sprayed onto its target host or the like. The moisture and pH then activates the organisms.
    Type: Grant
    Filed: October 7, 2008
    Date of Patent: August 12, 2014
    Inventor: James B. Watson
  • Publication number: 20140220663
    Abstract: The present invention provides a method for reducing the viscosity of a microorganism-containing suspension or concentrate and a method for obtaining a microorganism concentrate, wherein a monosaccharide and/or disaccharide and/or sugar alcohol is added to said microorganism-containing suspension or concentrate.
    Type: Application
    Filed: July 6, 2012
    Publication date: August 7, 2014
    Applicant: DUPONT NUTRITION BIOSCIENCES APS
    Inventors: Michel Cadenel, Patrick Chaigneau, Guy D'angloz, Erwan Henri, Jean Pierre Rocher
  • Publication number: 20140220555
    Abstract: Techniques for generating microtissues, including a micro-fabricated platform including at least one micro-well including a plurality of micro-cantilevers coupled thereto and surrounded by a plurality of ridges, each micro-cantilever including a cap at a terminal end thereof. The platform can be immersed in a suspension of cells. The suspension of cells can be driven into at least one micro-well, and the ridges can be de-wetted to remove excess suspension and isolate the suspension of cells in each micro-well. The cells can be driven in the suspension of each micro-well toward a top surface of the suspension, which can be polymerized to form a matrix. The cells can be cultivated to spontaneously compact the matrix such that the micro-cantilevers anchor and constrain the contracting matrix to form a band of microtissue that spans across the micro-cantilevers.
    Type: Application
    Filed: April 8, 2014
    Publication date: August 7, 2014
    Applicant: The Trustees of the University of Pennsylvania
    Inventors: Christopher S. Chen, Ken Margulies, Thomas Boudou, Wesley Legant, Michael T. Yang
  • Publication number: 20140220077
    Abstract: The present invention provides attenuated F. columnare strains that elicit an immune response in an animal, particularly a fish, against virulent F. columnare compositions comprising said strains, methods of vaccination against F. columnare, and kits for use with such methods and compositions. The invention further relates to a stabilization buffer, which allows the attenuated compositions to remain storage stable at ambient temperatures for extended periods of time.
    Type: Application
    Filed: January 31, 2014
    Publication date: August 7, 2014
    Applicant: Auburn University
    Inventors: Oscar Olivares-Fuster, Covadonga R. Arias
  • Patent number: 8795986
    Abstract: The invention relates to a method for the Bio-transformation of Thiocolchicine a colchicinoid compound into its glycosylated form using a selective microorganism Providencia vermicola. Use of bacterial strain, Providencia vermicola for microbial bio-transformation of thiocolchicine (TCN) to their corresponding 3-0-glycosyl derivative as well as specific strains of that species Providencia vermicola for microbial transformation of other colchicinoid compounds such as colchicine, thiocolchicine, 3-demethylcolchicine, 3-demethylthiocolchicine and N-deacetylthiocolchicine to its corresponding glycosylated form and subsequent isolation of the transformed compounds from the bacterial culture medium is disclosed. Providencia vermicola (MTCC 5578) a gram negative bacteria has been identified having trans-glycosylation ability and convert thiocolchicine (TCN) to Thiocolchicocide (TCS).
    Type: Grant
    Filed: September 22, 2011
    Date of Patent: August 5, 2014
    Assignee: Sequent Scientific Ltd.
    Inventors: Krishnamurthy Prabakaran, Sankarasubramanian Kanagavelrajan, Nallasamy Mohanasundaram Kannamapuram, Ayyappan Hariharan Kooakarakkaran, Bhimaraju Poliseti
  • Publication number: 20140212396
    Abstract: Provided herein are compositions comprising substantially non-viable Gram-negative bacterial organisms that have a substantial reduction in endotoxin activity and/or pyrogenicity and methods for treating a cancer using the same. Also provided are methods for treating cancer provided herein, comprising administering to a mammal diagnosed with cancer, substantially non-viable Gram-negative bacteria having a substantial reduction in endotoxin activity and/or pyrogenicity, in an amount sufficient to inhibit growth or metastasis of the cancer. An additional method is provided comprising administering viable or non-viable Gram-negative bacterial organisms that have a genetic defect that results in a substantial loss of lipopolysaccharide within the outer membrane of the bacteria. Further provided are methods for reducing endotoxin activity and/or pyrogenicity in Gram-negative bacteria comprising treatment with polymyxin and glutaraldehyde.
    Type: Application
    Filed: December 23, 2013
    Publication date: July 31, 2014
    Inventor: Michael J. Newman
  • Patent number: 8790909
    Abstract: The present invention relates to strains of Helicobacter pylori useful for the delivery of biologically active agents. In particular, the present invention provides an isolated strain of H. pylori having: (a) low pathogenicity; (b) ability to naturally transform; and (c) ability to colonise mouse stomach mucosa without host adaptation.
    Type: Grant
    Filed: June 3, 2010
    Date of Patent: July 29, 2014
    Assignee: Ondek Pty. Ltd.
    Inventors: Mohammed Benghezal, Alma Fulurija, Wei Lu, Hans-Olof Nilsson, Barry J. Marshall
  • Publication number: 20140206063
    Abstract: An automated biological growth and dispensing apparatus utilizing a modular growing tank which is removable for replacement by another growing tank. Mechanisms for the delivery of air, water and/or nutrients are adapted to permit the growing tank to be readily coupled and uncoupled for easy and inexpensive replacement. Mechanisms for agitation may be integral and removable with the growing tank or may be adapted for a quick connection and disconnection with the growing tank. The growing tank may be disposable and each new growing tank may be provided as a sealed container including a starting amount of a biomass and/or nutrient.
    Type: Application
    Filed: March 14, 2014
    Publication date: July 24, 2014
    Inventor: Heiner Ophardt
  • Publication number: 20140206067
    Abstract: The present invention relates to a process for providing purified bacteria-containing concentrates, comprising at least the steps of adding an aqueous solution to a first bacteria-containing concentrate to provide a bacteria-containing suspension, wherein the volume of the added aqueous solution is in the range of 0.3 liters to 10 liters per liter of said first bacteria-containing concentrate; and concentrating said bacteria-containing suspension to provide a second bacteria-containing concentrate. Further, the present invention relates to the purified concentrates per se.
    Type: Application
    Filed: August 20, 2012
    Publication date: July 24, 2014
    Applicant: CHR. HANSEN A/S
    Inventors: Tania Ivanova Georgieva, Anders Clausen, Tina Malling Thorsen
  • Publication number: 20140206048
    Abstract: The present invention provides compositions and methods for the use of oil-containing materials as feedstocks for the production the bioproducts by biofermentation. In one preferred embodiment, surfactants are not used in compositions and the methods of the invention. In one preferred embodiment the oil-containing feedstocks are the by-products of other industrial processes including microbial, plant and animal oil processing.
    Type: Application
    Filed: January 22, 2014
    Publication date: July 24, 2014
    Applicant: Glycos Biotechnologies, Inc.
    Inventors: Daniel J. Monticello, Ryan Black, Paul Campbell
  • Publication number: 20140206744
    Abstract: Provided are nucleic acid translators capable of carrying out logic operations with improved efficiency, maximized output and reduced off-target effects, in particular in a biological system. Methods of using these translators to transduce signal are also provided.
    Type: Application
    Filed: March 13, 2013
    Publication date: July 24, 2014
    Applicant: Emerald Therapeutics, Inc.
    Inventors: Daniel J. Kleinbaum, Brian M. Frezza, Brad Bond, Jonathan Leung, George W. Fraser
  • Publication number: 20140205693
    Abstract: The present invention relates to an extract from bacterial strains, such as Staphylococcus, Moraxella, Klebsiella, Streptococcus, and Haemophilus. The extract is useful as a treatment for indications such as respiratory disorders, compositions comprising the extract, and processes of making the extract from media that do not pose a risk of prion diseases.
    Type: Application
    Filed: March 20, 2014
    Publication date: July 24, 2014
    Applicant: OM PHARMA SA
    Inventors: Jacques Alain BAUER, Marco SALVAGNI, Jean-Pierre Leon VIGROUX, Laetitia CHALVET, Carlo CHIAVAROLI
  • Publication number: 20140206889
    Abstract: [Problem] The present invention addresses the problem of providing an anti-trypanosomal drug having a novel skeleton, in order to solve issues that occur with conventional technologies. [Solution] The present invention is based on the discovery of a microbe that produces an anti-trypanosomal drug having a novel skeleton. Specifically, this invention provides: a compound indicated by formula (I) having a trypanosomal inhibitory activity; an analog thereof; a production method therefor; and a Lechevalieria sp. Kl0-0216 strain that produces said compound.
    Type: Application
    Filed: August 31, 2012
    Publication date: July 24, 2014
    Applicant: THE KITASATO INSTITUTE
    Inventors: Satoshi Omura, Yoko Takahashi, Takuji Nakashima, Kazuhiko Otoguro, Kazuro Shiomi, Masato Iwatsuki, Atsuko Matsumoto
  • Patent number: 8785160
    Abstract: The invention provides methods and pharmaceutical compositions for treating symptoms associated with lactose intolerance and for overall improvement in gastrointestinal health. Described herein are methods and pharmaceutical compositions for improving overall gastrointestinal health or for decreasing symptoms of lactose intolerance by administering to subject in need thereof a pharmaceutical composition comprising a prebiotic, optionally in combination with effective amount of a probiotic microbe or microbes.
    Type: Grant
    Filed: April 28, 2011
    Date of Patent: July 22, 2014
    Assignee: Ritter Pharmaceuticals, Inc.
    Inventors: Andrew J. Ritter, Dennis Savaiano, David Barnes, Todd Klaenhammer
  • Publication number: 20140199753
    Abstract: Novel strains and methods for their use are provided. Particularly, foods and other oral products or treatments containing sporulation-deficient Brevibacillus strain when administered to a subject can inhibit or reduce the number of pathogens in the subject and improve the health of the subject.
    Type: Application
    Filed: February 13, 2014
    Publication date: July 17, 2014
    Applicant: MYGALAXY Limited Company
    Inventor: Yiwei Jiang
  • Publication number: 20140194345
    Abstract: The present invention relates generally to novel depsipeptides, to methods for the preparation of these novel depsipeptides, to pharmaceutical compositions comprising the novel depsipeptides; and to methods of using the novel depsipeptides to treat or inhibit various disorders.
    Type: Application
    Filed: December 3, 2013
    Publication date: July 10, 2014
    Inventors: Aaron J. Peoples, Dallas Hughes, Losee Lucy Ling, William Millett, Anthony Nitti, Amy Spoering, Victoria Alexandra Steadman, Jean-Yves Christophe Chiva, Linos Lazarides, Michael Kenyon Jones, Karine Gaelle Poullenec, Kim Lewis
  • Patent number: 8772013
    Abstract: A composition comprising intact minicells that contain a drug molecule is useful for targeted drug delivery. One targeted drug delivery method employs bispecific ligands, comprising a first arm that carries specificity for a bacterially derived minicell surface structure and a second arm that carries specificity for a mammalian cell surface receptor, to target drug-loaded minicells to specific mammalian cells and to cause endocytosis of the minicells by the mammalian cells. Another drug delivery method exploits the natural ability of phagocytic mammalian cells to engulf minicells without the use of bispecific ligands.
    Type: Grant
    Filed: January 27, 2005
    Date of Patent: July 8, 2014
    Assignee: Engeneic Molecular Delivery Pty Ltd
    Inventors: Himanshu Brahmbhatt, Jennifer MacDiarmid
  • Patent number: 8772015
    Abstract: A biofilter media has one or more of a set of desired physical characteristics. The set of physical characteristics includes a sphericity of 0.75 to 1, a particle size of 1 to 16 or 4 to 8 mm, a uniformity coefficient of 2 or less and a surface area of 800 to 2000 m2/m3 of media. The media is coated, supports microorganisms and is used to treat a waste gas stream.
    Type: Grant
    Filed: October 3, 2008
    Date of Patent: July 8, 2014
    Assignee: Biorem Technologies Inc.
    Inventors: Hidayat Husain, Brian P. Herner
  • Patent number: 8771676
    Abstract: The present invention provides an agrochemically active microbial formulation comprising a combination of an agrochemically active microbe with a specified ester compound and a surfactant, the formulation exhibiting a stable pest controlling effect with no harmful effect on a plant and having highly stable viability of the agrochemically active microbe.
    Type: Grant
    Filed: June 22, 2007
    Date of Patent: July 8, 2014
    Assignee: Sumitomo Chemical Company, Limited
    Inventors: Shinya Kimura, Yoshiki Takashima, Takeshi Maruyama
  • Publication number: 20140186475
    Abstract: The invention discloses a bacterial strain of non pathogenic Cobetia marina useful in aquaculture, corresponding to an isolated Cobetia marina strain, Gram negative, oxidase positive, deposited under registry number CECT N° 7764; grows with dibenzothiophene (DBT) as the only carbon source. Also disclosed is a method to obtain a biosurfactant surfactant extract comprising growing strain Cobetia marina (MM1IDA2H-1) CECT N° 7764 in a reactor with liquid growth medium from 24 to 48 hours at a temperature between 10 and 35° C., pH 6 to 8; constant stirring between 100 to 400 rpm and oxygen saturation between 10 to 21%; until obtaining a grown cell culture and extracellular products plus inorganic salts; separating the cells, lyophilizing supernatant, sieve the obtained powder and dry.
    Type: Application
    Filed: May 30, 2012
    Publication date: July 3, 2014
    Applicant: UNIVERSIDAD DE VALPARAISO
    Inventors: Miguel Alejandro Dinamarca Tapia, Juan Ricardo Ojeda Herrera, Claudia Jimena Ibacache Quiroga
  • Publication number: 20140187818
    Abstract: The invention relates to a bacterial strain belonging to the genus Rhodococcus which is a producer of a nitrile hydratase. The invention also relates to a method for producing acrylamide by hydration of acrylonitrile using a biomass of the bacterial strain and to a method of culturing the bacterial strain.
    Type: Application
    Filed: December 24, 2013
    Publication date: July 3, 2014
    Inventors: Sergey Vladimirovich Kozulin, Tatiana Nicolaevna Kozulina, Alexey Sergeevich Kozulin
  • Publication number: 20140186385
    Abstract: The present invention discloses novel isolates of Neorickettsia risticii, compositions comprising such isolates, vaccines and methods for using such vaccines against Potomac Horse Fever.
    Type: Application
    Filed: December 10, 2013
    Publication date: July 3, 2014
    Applicant: Intervet Inc.
    Inventors: Lisa Purtle, Mark Mellencamp, Wendy Vaala
  • Patent number: 8765404
    Abstract: Some aspects of this invention relate to methods useful for the conversion of a carbon source to a biofuel or biofuel precursor using engineered microbes. Some aspects of this invention relate to the discovery of a key regulator of lipid metabolism in microbes. Some aspects of this invention relate to engineered microbes for biofuel or biofuel precursor production.
    Type: Grant
    Filed: March 2, 2011
    Date of Patent: July 1, 2014
    Assignee: Massachusetts Institute of Technology
    Inventors: Gregory Stephanopoulos, Syed Hussain Imam Abidi
  • Patent number: 8765399
    Abstract: Disclosed are culture media, protocols and kits for diagnosis of toxigenic Clostridium difficile, where the culture medium comprises Cooked Meat Medium with glucose; yeast extract; taurocholate; cycloserine; and cefoxitin.
    Type: Grant
    Filed: May 17, 2011
    Date of Patent: July 1, 2014
    Assignee: Montefiore Medical Center
    Inventor: Paul Riska
  • Patent number: 8765118
    Abstract: The present invention relates to a novel wild-type Lactococcus lactis subsp. cremoris bacteria strain with increased vitamin K2 production and mutants and variants thereof and methods for preparation of a fermented food or feed product enriched in vitamin K2 and a vitamin K enriched edible product for amelioration and/or prevention of vitamin K deficiency. The present invention also relates to the fermented food or feed product and the edible product obtainable by the methods herein and to the wild-type Lactococcus lactis subsp. cremoris bacteria strain for use in treatment and/or prevention of vitamin K deficiency in a mammal, such as a human.
    Type: Grant
    Filed: August 11, 2011
    Date of Patent: July 1, 2014
    Assignee: Chr. Hansen A/S
    Inventors: Christel Garrigues, Martin Bastian Pedersen
  • Patent number: 8765445
    Abstract: The present invention provides an equol-producing lactic acid bacteria-containing composition comprising, as an essential component thereof, a lactic acid bacterial strain belonging to the genus Lactococcus having an ability to utilize at least one daidzein compound selected from the group consisting of daidzein glycosides, daidzein, and dihydrodaidzein to produce equol. Such a composition is effective for the prevention and alleviation of malaise inclusive of climacteric disturbance in middle-aged and elderly women for which no effective prophylactic method or alleviating means has heretofore been available.
    Type: Grant
    Filed: June 29, 2004
    Date of Patent: July 1, 2014
    Assignee: Otsuka Pharmaceutical Co., Ltd.
    Inventors: Shigeto Uchiyama, Tomomi Ueno, Toshimi Suzuki
  • Publication number: 20140178983
    Abstract: A heat exchanger system includes a heat exchanger having a body plate with a first side face and an opposing second side face, the body plate bounding a fluid channel disposed between the opposing side faces and extending between an inlet port and an outlet port, and a first side plate having an inside face. A flexible first bag includes of one or more sheets of polymeric material, the first bag bounding a fluid pathway that extends between a fluid inlet and a fluid outlet, the first bag being removably retained between the body plate and the first side plate so that at least a portion of the first bag rests against the first side face of the body plate when the fluid pathway of the first bag is filled with a fluid.
    Type: Application
    Filed: November 22, 2013
    Publication date: June 26, 2014
    Applicant: HYCLONE LABORATORIES, INC.
    Inventors: Clinton C. Staheli, Nephi D. Jones, Michael E. Goodwin
  • Publication number: 20140178433
    Abstract: The antigenic mass of Leptospira cultures can be significantly increased, independent from any increase in biomass, by supplementing Leptospira cultures with a specific fatty acid: linoleic acid. This provides advantages in the production Leptospira antigens. Also this enables the production of improved Leptospirosis vaccines, that are safer and more effective.
    Type: Application
    Filed: December 16, 2013
    Publication date: June 26, 2014
    Inventors: Edwin Kets, Christian Theodoor Gerardus Smits, Henriette Adriaanse
  • Publication number: 20140178952
    Abstract: The invention provides a simple and effective method for improving acid tolerance of P. acdipropionici by adding arginine and/or aspartic acid to the culture medium. The acid tolerance of P. acdipropionici was improved by 60% and 20% respectively through adding arginine or aspartic acid into the culture medium. Consequently, PA production was improved by 36% and 26%, respectively. The maximal PA production was obtained by adding both 20 mM arginine and 20 mM aspartic acid. This method can be applied to large scale production of PA.
    Type: Application
    Filed: October 7, 2013
    Publication date: June 26, 2014
    Inventors: Jian Chen, Guocheng Du, Long Liu, Jianghua Li, Ningzi Guan
  • Publication number: 20140178439
    Abstract: A method of preparing a capturing agent for a selected biopolymer or bioparticle, includes the steps of: a) selecting a desired biopolymer or bioparticle, and b) providing a support matrix modified to have, at predetermined conditions, such a net negative surface charge and net surface hydrophobicity in relation to the net negative surface charge and the net surface hydrophobicity of the selected biopolymer or bioparticle that the modified support matrix is capable of selective interaction and capture of the biopolymer or bioparticle through a resulting net hydrophobic interaction being the actual hydrophobic interaction minus the actual electrostatic repulsion. The use of such a capturing agent as a therapeutically active substance, as well as in chromatography and diagnosis are also disclosed.
    Type: Application
    Filed: July 20, 2012
    Publication date: June 26, 2014
    Inventor: Stellan Hjerten
  • Publication number: 20140178970
    Abstract: An isolated microbial consortia is described. The consortia may include a first-bite microbial consortium that converts a starting hydrocarbon that is a complex hydrocarbon into two or more first-bite metabolic products. The consortia may also include a downstream microbial consortium that converts a starting hydrocarbon metabolic product into a downstream metabolic product. The downstream metabolic product has a greater mol. % hydrogen than the starting hydrocarbon. The first-bite microbial consortium or the downstream microbial consortium includes one or more species of Desulfuromonas.
    Type: Application
    Filed: October 8, 2013
    Publication date: June 26, 2014
    Applicant: Luca Technologies, Inc.
    Inventor: Gary Vanzin
  • Publication number: 20140178971
    Abstract: Bacteria that can use antibiotics as a carbon source are provided. Methods and bacteria useful for bioremediation are also provided.
    Type: Application
    Filed: December 27, 2013
    Publication date: June 26, 2014
    Inventors: George M. CHURCH, Gautam DANTAS, Morten O. SOMMER
  • Publication number: 20140179942
    Abstract: The invention relates to a micro-organism comprising a hydrogenase enzyme system which is capable of converting carbon dioxide into formic acid and a second enzyme system which is capable of converting formic acid into aliphatic carboxylic acids having a chain length of five or more carbon atoms. Also described are various methods for producing oil, as well as other aspects of the invention.
    Type: Application
    Filed: July 13, 2012
    Publication date: June 26, 2014
    Applicant: VERDANT BIOPRODUCTS LIMITED
    Inventor: Irene Finnegan
  • Patent number: 8759032
    Abstract: A genetically engineered strain WSJ-IA for producing isovaleryl spiramycin I. Also provided is a method for preparing the strain, including the steps of: (a) constructing a recombinant plasmid including a double gene ist-acyB2; (b) transforming the plasmid into an isovaleryl spiramycin I-producing strain to obtain the strain WSJ-IA. The level of isovaleryl spiramycin I produced by fermentation of the strain WSJ-IA is increased 1.7 times and the fermentation potency thereof increased 4.14 times in comparison with the strain exclusively including a single gene ist.
    Type: Grant
    Filed: July 21, 2011
    Date of Patent: June 24, 2014
    Assignee: Shen Yang Tonglian Group Co., Ltd.
    Inventors: Yiguang Wang, Yang Jiang, Shengwu Yang, Xiaofeng Zhao
  • Patent number: 8759069
    Abstract: Contamination was controlled in fermentations using Zymomonas mobilis as the biocatalyst, without negative impact on fermentation production, by the addition of hop acids. The effective concentration of hop acids was found to be dependent upon the type of fermentation medium used.
    Type: Grant
    Filed: June 15, 2012
    Date of Patent: June 24, 2014
    Assignee: E I du Pont de Nemours and Company
    Inventors: George C Fox, Maria C Leana, Brian G Lefebvre
  • Patent number: 8759021
    Abstract: Provided are a microorganism for use in quantification of homocysteine and methionine and a method of quantifying homocysteine and methionine in a sample by using the microorganism.
    Type: Grant
    Filed: May 20, 2010
    Date of Patent: June 24, 2014
    Assignee: Labgenomics Co., Ltd.
    Inventors: Hyun Gyu Park, Min-Ah Woo, Moon Il Kim, Sang-Joon Hwang, Dae-Yeon Cho
  • Patent number: 8759494
    Abstract: The invention relates to antibodies to the tumor-associated antigen CD33 and to the use thereof for immunotargeting CD33-positive cells. The antibodies according to the invention are suitable for use in the field of medicine, pharmaceuticals, and biomedical research. According to the invention, the aim is achieved by means of novel anti-CD33 antibodies comprising the complementary determining regions (CDRs) defined in the claim. The antibodies according to the invention are characterized by a high affinity for human CD33, of the order of magnitude of 10?10 mol/l. The CDR sequences according to the invention are suitable in particular for producing recombinant fragments (such as scFv fragments or bispecific antibodies) and for immunotargeting, due to the high affinity thereof.
    Type: Grant
    Filed: September 22, 2010
    Date of Patent: June 24, 2014
    Assignee: GEMoaB Monoclonals GmbH
    Inventors: Michael Bachmann, Slava Stamova
  • Publication number: 20140170637
    Abstract: Methods for aiding in the diagnosis of disorders including, but not limited to, PDDs (Pervasive Development Disorders), Dysautonomic disorders, Parkinson's disease and SIDS (Sudden Infant Death Syndrome). In one aspect, a diagnosis method comprises analyzing a stool sample of an individual for the presence of a biological marker (or marker compound) comprising one or more pathogens, which provides an indication of whether the individual has, or can develop, a disorder including, but not limited to, a PDD, Dysautonomia, Parkinsons disease and SIDS. Preferably, the presence of one or more pathogens is determined using a stool immunoassay to determine the presence of antigens in a stool sample, wherein such antigens are associated with one or more pathogens including, but not limited to, Giardia, Cryptosporidium, E. histolytica, C. difficile, Adenovirus, Rotavirus or H. pylori.
    Type: Application
    Filed: September 26, 2013
    Publication date: June 19, 2014
    Applicant: Curemark, LLC
    Inventor: Joan M. Fallon
  • Publication number: 20140171482
    Abstract: The present invention is directed to transfection complexes of rosette nanotubes and one or more nucleic acids.
    Type: Application
    Filed: January 3, 2012
    Publication date: June 19, 2014
    Applicants: RHODE ISLAND HOSPITAL, Brown University
    Inventors: Thomas J. Webster, Qian Chen, Yupeng Chen
  • Publication number: 20140170190
    Abstract: The present invention provides attenuated M. haemolitica strains that elicit an immune response in animal against M. haemolitica, compositions comprising said strains, methods of vaccination against M. haemolitica, and kits for use with such methods and compositions. The invention further provides multi-valent vaccines, which provide protective immunity when administered in an effective amount to animals susceptible to “shipping fever” or bovine respiratory disease.
    Type: Application
    Filed: November 8, 2013
    Publication date: June 19, 2014
    Applicant: MERIAL LIMITED
    Inventors: Russell F Bey, Paulraj Kirubakaran Lawrence, Randy R Simonson
  • Publication number: 20140170168
    Abstract: Provided are isolated high affinity entities which comprise an antigen binding domain which specifically binds a soluble T-cell receptor ligand comprising a two-domain beta1-alpha1 of a major histocompatibility complex (MHC) class II, wherein said antigen binding domain does not bind a complex comprising a four-domain alpha1-beta1/alpha2-beta2 MHC class II. Also provided are methods and kits using same for detecting and sequestering soluble two-domain T cell receptor ligands in a sample.
    Type: Application
    Filed: October 26, 2011
    Publication date: June 19, 2014
    Inventors: Yoram Reiter, Rony Dahan, Arthur A. Vandenbark
  • Publication number: 20140162343
    Abstract: Novel strains and methods for their use are provided. Particularly, foods and other oral products or treatments containing sporulation-deficient Brevibacillus strain when administered to a subject can inhibit or reduce the number of pathogens in the subject and improve the health of the subject.
    Type: Application
    Filed: February 13, 2014
    Publication date: June 12, 2014
    Inventor: Yiwei Jiang
  • Publication number: 20140161781
    Abstract: The invention relates to a zinc-enriched biomass comprising living or subsequently killed micro-organisms, selected from the group consisting of Streptococcus thermophilus and Bifidobacterium animalis subsp. lactis and combinations thereof, a method for the manufacture of said zinc-enriched biomass, as well as food preparations, nutraceutic products, functional foods, cosmetic and cosmeceutic products, and food supplements, comprising the said biomass. Furthermore, new micro-organism strains are described which are able to concentrate zinc within the cell in very high amounts and therefore are particularly suitable for use in the method of the invention.
    Type: Application
    Filed: November 4, 2013
    Publication date: June 12, 2014
    Inventors: Alberto BENEDETTI, Francesco GIRARDO
  • Patent number: 8748154
    Abstract: The present invention relates to a Sphingomonas sp. MD2 strain (KCTC 11845BP), a composition including the strain for decomposing methane or odor-producing compounds, a biocover or biofilter including the composition, a method for decomposing methane or odor-producing compounds using the composition, a system for decomposing methane or odor-producing compounds using the biocover or biofilter, and the use of the strain for decomposing methane or odor-producing compounds. According to the present invention, methane and odor can be effectively removed concurrently, and thus the cost required for the separate treatment of methane and odor can be reduced, and methane and odor-producing compounds in landfills or the like can be effectively decomposed.
    Type: Grant
    Filed: March 25, 2011
    Date of Patent: June 10, 2014
    Assignee: EWHA University-Industry Collaboration Foundation
    Inventors: Kyung Suk Cho, Jung Hee Lee, Kyung Eun Moon, Tae Gwan Kim, Sang Hyon Lee
  • Publication number: 20140155586
    Abstract: A compound having a structure expressed by the following Structural Formula (1), tautomers thereof, or salts of the compound or the tautomers.
    Type: Application
    Filed: October 21, 2011
    Publication date: June 5, 2014
    Inventors: Masayuki Igarashi, Ryuichi Sawa, Yoshiko Homma
  • Publication number: 20140154218
    Abstract: According to the present invention, an anti-allergic agent is provided which includes a polysaccharide comprising galactose, glucose and rhamnose as constituents, or includes a microorganism belonging to a genus Bifidobacterium and extracellularly producing the polysaccharide. The anti-allergic agent of the present invention can be used in oral compositions and compositions for external application, and is suitable for use in products such as food products, pharmaceutical products, and cosmetics.
    Type: Application
    Filed: February 10, 2014
    Publication date: June 5, 2014
    Applicant: MORISHITA JINTAN CO., LTD.
    Inventors: Mamiko KOHNO, Shinichi KITAMURA, Aiko SHOJO
  • Publication number: 20140154217
    Abstract: New Lactococcus lactis strains, NRRL B-50571 and NRRL B-50572, and a bacterial preparation containing the same, have the ability to produce bioactive peptides that reduce blood pressure, lower LDL-cholesterol (bad cholesterol) and present antioxidant properties for better cardiovascular health. These biologically active peptides may be produced within the food for the production of a food product, such as a functional food, or they may be produced from protein sources and subsequently added to a food as part of the formulation or as part of a food supplement or a pharmaceutical preparation.
    Type: Application
    Filed: September 27, 2012
    Publication date: June 5, 2014
    Applicants: CENTRO DE INVESTIGACION EN ALIMENTACION Y DESARROLLO, A.C. (CIAD)
    Inventors: BELINDA VALLEJO GALLAND, AARÓN FERNANDO GONZÁLEZ CÓRDOVA, JOSÉ CARLOS RODRÍGUEZ FIGUEROA