Abstract: A dosing assembly (204) and/or a container (202) comprising fastening means (206,208) for fastening the container to the dosing assembly, the fastening means of the dosing assembly and/or the container defining an asymmetrical pattern in a plane transverse to an axial direction of the dosing assembly and/or a container.

Abstract: The present invention is directed to an automatic reconstitution drug delivery device. The inventive device effects simple and automatic reconstitution of a dry drug. To effect reconstitution, a user displaces a release button which causes first and second chambers of a drug cartridge to communicate, resulting in automatic mixing of a diluent and dry drug to effect reconstitution of the dry drug. The user then simply sets the dose volume using a dose-setting mechanism, and administers the injection in a manner typical of self-injection drug delivery devices. Whole or partial automatic priming can be also achieved by the device.

Abstract: The invention concerns an injection device for apportioning set doses of a drug from a reservoir to a subject. The injection device comprises a dose setting member (20, 70) which is screwed out from the housing (30) to set a dose and pushed axially back to the housing (30) in order to expel the set dose. A scale drum (80) is axially and inrotatable coupled to the dose setting member (20, 70) such that the scale drum (80) is rotated up a thread (34) when the dose setting member (20, 70) is rotated to set a dose. When the dose setting member (20, 70) is pushed axially back to its initial position to inject the set dose, the scale drum (80) is released from its inrotatable connection in order to allow the scale drum (80) to rotate down the thread (34) and back to its zero position.

Abstract: A valve is provided for controlling flow along a fluid line that includes an outer shell and an inner housing slidably disposed therein that includes connector threads surrounding a boss on one end and a passage through the boss. A backing member is coupled to the outer shell and has a sealing pin extending into the passage. A connector may be threaded into the one end of the inner housing, thereby slidably engaging the connector threads, causing the inner housing to move helically from a closed position wherein the sealing pin engages an outlet opening at the distal end of the boss to seal the outlet opening and an open position wherein the inner housing is directed away from the sealing pin to open a fluid path through the valve, around the pin, and through the outlet opening.

Abstract: A stopper adapted for attachment with a plunger rod for use within a syringe barrel includes: a main body portion defining an open rearward end configured to receive the plunger rod and a closed front end; and a stopper scale line formed along an outer edge of the main body portion. The stopper scale line is formed to provide a visual enhancement of a portion of the stopper that aligns with volume measuring demarcations provided along the syringe barrel, and the stopper scale line contrasts with the main body portion of the stopper.

Abstract: A method and system for priming a drug delivery device. The drug delivery device includes a dose dial sleeve and an internal housing portion. The dose dial sleeve is coupled to the internal housing. The dose dial sleeve rotates on a substantially circumferential rotational path during priming of the drug delivery device. Further, the dose dial sleeve rotates on a helical path during dose setting of the drug delivery device.

Abstract: A medication delivery device comprising a housing, a medication receptacle, a piston rod which is moveable distally, and a drive device for rotating the piston rod in a first rotational direction. The piston rod comprises two threaded sections, a first threaded section for threaded engagement with a reset element and a second threaded section for threaded engagement with the drive device. In an operational state, the reset element is prevented from rotating and the piston rod prevented from moving proximally. In a resetting state, the reset element is allowed to rotate, such that the delivery device is resettable by rotating the piston rod and the reset element in a second rotational direction and moving the piston rod proximally.

Abstract: A medical delivery system (200) having a container (202) and a dosing assembly (204), where the container is fastenable to the dosing assembly by a movement comprising a translatory movement followed by a rotational movement. One of the container and the dosing assembly comprises one or more blocking elements (207) movable between a blocking position and a non-blocking position responsive to the rotational movement. Each blocking element is able to engage the other one of the container and the dosing assembly. A container suitable for use in said medical delivery system.

Abstract: The present disclosure is directed to a dose setting mechanism that may be used with a drug delivery device. The dose setting mechanism may include an inner body having a helical thread along an outer cylindrical surface of the inner body, and a drive sleeve for driving a piston rod in an axial direction, the drive sleeve positioned within at least a portion of the inner body. The dose setting mechanism may further include a dose dial sleeve rotatably engaged with the helical thread of the inner body and a dial grip connected to the dose dial sleeve and releasably connected to the drive sleeve. Further when a dose is set, the dial grip is rotated so that both the dose dial sleeve and the drive sleeve rotate with respect to the inner body.

Abstract: The present invention relates to a dose setting mechanism for a drug delivery device and a method of using same. The mechanism comprises a drug delivery device housing, a dose dial component positioned in the housing and rotatable during dose setting and dose delivery, a clutch rotatable during dose setting and non-rotatable during dose delivery having, preferably located at a distal end, clutch teeth, and a clutch ring engaged with the housing in a first rotatable configuration and in a second non-rotatable configuration.

Abstract: A reservoir module for an administering apparatus, the reservoir module including a rotational block which permits the rotational dosing movement in a first rotational direction and blocks the rotational dosing movement in a second rotational direction, wherein the rotational block includes at least one first rotational stopper and at least one second rotational stopper, the first rotational stopper and the second rotational stopper abut against one another in the end position of the dosage setting member, wherein the dosage setting member is moved away from the translational stopper by the permitted rotational dosing movement.

Abstract: A linear cartridge-type motorized dental syringe has a plunger rod aligned with a drive shaft of a motor, the externally threaded plunger rod movable longitudinally, but not rotatably, relative to the casing, a cylindrical body rotated by the shaft, a nut having arm-like nut halves with internal threads engaging external threads on the rod, a locking ring for rotation around an axis of the rod and for longitudinal movement between a rearward position where the ring forces the threads on the nut halves to engage the threads on the rod, and forward where the ring releases engagement of the threads, pusher pins for moving the ring rearward when the cartridge holder is inserted, and a spring for pushing the locking ring back to the forward position, with rotation of the cylinder body resulting in rotative motion of the nut around the rod to move it forward.

Abstract: The invention relates to a device (1) for delivering two predetermined doses of a product (3), comprising: —a container (2) for containing said product, said container having a distal end (2d) through which the product is delivered under the distal pressure of a piston, —a pusher (7) movable with respect to said container for causing said piston (4) to move in the distal direction from an initial position, in which none of said product has been expelled to a first position, in which a first dose of said product has been expelled, and to a second position, in which a second dose of said product has been expelled, —a holder body (15) receiving said container and said pusher (7), —biasing means (22) for urging said pusher (7) in the distal direction, from the initial to the first position, and to the second position, —first and second retaining means (9, 11, 19) for maintaining said pusher (7) in said initial position, and in said first position, —first and second actuation means (18) to deactivate said first an

Abstract: An injection device having a safeguard for preventing a filling or adjusting motion of the injection device when a prescribed dispensing motion has been performed, the injection device including an adjusting element and/or a filling element, a blocking mechanism including a first blocking element and a second blocking element, the blocking mechanism allowing a motion of the adjusting and/or filling element in a release position and preventing the motion in a blocking position, and a piston rod including a block trigger element that can bring one of the blocking elements into interaction with the other blocking element thereby creating a blocking position at a prescribed insertion position to cause a blocking of at least one of the adjusting element and/or the filling element.

Abstract: A pen type device for ultrasound guided fine needle aspiration cytology and biopsy comprises a hollow body having a needle hole, a sliding part slidably mounted inside the body, elastic members mounted inside the body, a syringe having a cylinder mounted, a rotating part disposed inside the sliding part and the body, a head screw-coupled to the rear end of the sliding part and drawn out from the body, and a negative pressure generating part mounted on the body to generate negative pressure to the syringe by pulling a piston of the syringe when a button located on the outer face of the body is pushed.

Abstract: A drive mechanism suitable for use in drug delivery devices is disclosed. The drive mechanism may be used with injector-type drug delivery devices, such as those permitting a user to set the delivery dose. The drive mechanism may include a housing, a dose dial sleeve, and a drive sleeve. A clutch is configured to permit rotation of the drive sleeve and the dose dial sleeve with respect to the housing when the dose dial sleeve and drive sleeve are coupled through the clutch. Conversely, when the dose dial sleeve and drive sleeve are in a de-coupled state, rotation of the dose dial sleeve with respect to the housing is permitted and rotation of the drive sleeve with respect to the housing is prevented. In the de-coupled state, axial movement of the drive sleeve transfers force in a longitudinal direction for actuation of a drug delivery device.

Abstract: Disclosed herein are various examples of a drug delivery system having a non-detachable reservoir holder. The drug delivery system includes a dose setting mechanism and a reservoir holder attached to the dose setting mechanism, wherein the reservoir holder is configured to partially detach from the dose setting mechanism to allow for (i) insertion of a reservoir into the reservoir holder without being fully detached from the dose setting mechanism and (ii) removal of the reservoir from the reservoir holder without being fully detached from the dose setting mechanism.

Abstract: An administering apparatus including a rotational block which, in the end position of the dosage setting member, permits the rotational dosing movement in a first rotational direction and blocks the rotational dosing movement in a second rotational direction, wherein the rotational block comprises at least one first rotational stopper and at least one second rotational stopper, the first rotational stopper and the second rotational stopper abutting against one another in the end position of the dosage setting member, wherein the at least one first rotational stopper is secured against rotating by the dosage setting member and the at least one second rotational stopper is secured against rotating by the casing.

Abstract: An injection control device having a metered/controlled injection rate, that is proportional to the rate of withdrawal/injection—suitable for cosmetic as well as other applications—is described. For an injection mode, after the cannula is advanced into an object, the cannula is withdrawn to create a tract or tunnel within the targeted area. As the cannula is withdrawn, filler material in the injection control device is uniformly deposited into the tract or tunnel via the automatic metering system. The automatic metering system incorporates a syringe activating mechanism coupled to a gearing system which is capable of proportioning the deposition (or sucking) rate to the retraction/injection rate of the cannula. Accordingly, more consistent and uniform distribution (or harvesting) of material can be achieved with less cannula passes as well as requiring less dependence on the skills of the practitioner of this device.

Abstract: A click pen applicator device that provides predetermined dosing of the formulation for precise application, and rapidly primes the formulation using the dosing click mechanism to prepare the applicator for use is disclosed.

Abstract: The present patent application relates to delivery devices, methods, and systems of delivering at least one medicament from a reservoir using an automatic delivery device. Such an automatic delivery device system may comprise a dose injecting mechanism and a dispense interface, such as a needle module. The dose injecting mechanism comprises a triggering mechanism. An activating member, such as a needle guard of the needle module, can be used to initiate the triggering mechanism to enable the device to administer the set dose. The single dispense interface may comprise a medicated module containing at least one dose of a secondary medicament. The dose injecting mechanism may comprise a dose setting mechanism.

Abstract: The present invention relates to a medicament delivery device comprising a generally elongated housing comprising a distal and a proximal housing part having opposite distal and proximal ends; a medicament container coaxially arranged within said proximal housing part; drive means (18, 20, 22, 23, 30, 32) arranged to act on said medicament container for expelling a dose of medicament; and an electromechanical dose setting mechanism interactively connected to said drive means; wherein said electromechanical dose setting mechanism comprises a manually operable dose setting button (38); a dose setting member (34) comprising sensors (42) and arranged to be linearly displaced a predetermined distance along a linear path when the dose setting button is manually operated; and a printed circuit board (44) having a code sensing area (46) along the linear path of movement of the sensors, and wherein the sensors are arranged adjacent said code sensing area, such that a value of the immediate position of the dose setting

Abstract: A device for administering an injectable substance, the device including a housing, a translation member moveable in a translation direction, a rotation member rotatably moveable about a rotation axis and coupled to the translation member to support the translation member counter to the translation direction, a rotary bearing including a bearing body bearing the rotation member rotatably about the rotation axis, the rotary bearing having support surfaces for supporting the rotation member axially on the bearing body, and a device for reducing play whereby at least two support surfaces are brought into contact with a pressing force, thereby reducing an axial play of the rotary bearing.

Abstract: A dose setting mechanism having a locking mechanism for preventing selection of a dose in a drug delivery device is disclosed. The dose setting mechanism includes a locking mechanism that prevents movement of the dose setting mechanism. When a correct cartridge is inserted into the drug delivery device, the locking mechanism unlocks so as to allow movement of the dose setting mechanism. In one arrangement, the locking mechanism prevents rotation of the dose setting mechanism.

Abstract: An injection device (30) features a housing (42, 52) for reception of a container (34) having a fluid (32) to be injected, a first element (94) for ejecting injection fluid (32) from such a container (34), and said first element (94) has an external thread (92). A metering element (66, 88) has an internal thread (90) that is in engagement with the external thread (92) of the first element (94), and said metering element (66) is rotatable, together with the first element (94), for preselection of a desired injection dose. A coupling arrangement (K1) serves, during an injection operation, to create a nonrotatable connection between the first element (94) and the housing (42, 52) and thereby to block, during an injection operation, a rotation of the first element (94) relative to the housing (42, 52) but to enable a rotation of the metering element (66, 88) relative to the housing (42, 52).

Abstract: The present invention relates to a dose setting mechanism for a drug delivery device and a method of using same. The mechanism comprises a housing, a mechanism member movable in a first axial direction relative to the housing during dose setting and movable in a second, opposite axial direction relative to the housing during injection, wherein the mechanism member is designed and arranged such that the mechanism member is able to change its condition between a first condition preventing movement in the second axial direction and a second condition allowing movement in the second axial direction, and a switching member forcing the mechanism member to change from its second condition into its first condition at a predefined position of the movement in the first axial direction during dose setting.

Abstract: A drug delivery device comprises a first component and a second component, wherein a substance is provided on at least one of the first component and the second component. An inner friction of the substance is great enough to stabilize at least one of the orientation and the position of the first component and the second component with respect to one another. The inner friction of the substance is small enough to allow relative movement of the first component and the second component necessary for the intended operation of the device. Furthermore, a method for assembling a drug delivery device is provided.

Abstract: A flow rate sensor is provided in a wireless, leadless package. The flow rate sensor includes a MEMs sensor coupled to an ASIC and an antenna. The flow rate sensor is powered by radiation received from a control module adjacent the flow rate sensor. The flow rate sensor is placed within a fluid and monitors the flow rate of the fluid. The control module is not in the fluid and receives flow rate data from the flow rate sensor.

Abstract: A device for administering a product dose, the device including a display drum for displaying the product dose, a housing, a first conveying member moveable relative to the housing in a conveying direction, a second conveying member moveable relative to the housing in and counter to the conveying direction, the second conveying member in a first threaded engagement with the first conveying member while being rotationally movable relative to the housing and the first conveying member and being translationally movable relative to the first conveying member counter to the conveying direction, a metering apparatus by which the product dose can be adjusted and which encompasses the display drum, the display drum being rotationally movable relative to the housing while being translationally movable in and counter to the conveying direction in a second threaded engagement, and a coupling element which interconnects the first conveying member and the display drum in a torsion-resistant manner in a coupling engagement

Abstract: The present invention relates to a device for automatic injection of a product, comprising: a body (3) housing a container, the container being movable relative to said body between an initial position, to an insertion position; a safety shield (26) movable with respect to said container and said body between an insertion position to a protection position, when the user removes the device from an injection site; an external socket (48) receiving the body and provided with selection means (53) which can be placed by a user: either in a first position, in which the body (3) and the external socket (48) are bound to each other, the safety shield extending beyond the distal end of both said body and said external socket in the protection position; or in a second position, in which the external socket (48) is able to move axially in the distal direction with respect to the body (3), both the safety shield and the external socket extending beyond the distal end of said body, in the protection position.

Abstract: A system for preventing delivery of less than a predetermined minimum dose of a medicament by providing a dose setting mechanism having a clutch ring rotationally fixed relative to the housing when a dose less than the minimum allowable dose is selected. The dose setting mechanism also includes a drug delivery device housing and a dose dial component positioned in the housing and rotatable during a dose setting step. A drive sleeve is positioned within the dose dial component, a spindle is positioned within the drive sleeve, and a clutch is positioned between the dose dial component and the drive sleeve. When the dose dial component is rotated to select a dose less than a minimum dose, a clutch ring prevents the drive sleeve from rotating to thereby prevent the selected dose from being administered.

Abstract: A method and system for preventing delivery of less than a predetermined minimum dose of a medicament by providing a dose setting mechanism having a spindle nut and a sprung lock nut. The mechanism includes a housing and a dose dial component positioned in the housing. The dose dial component is rotatable during a dose setting step. The mechanism further includes a drive sleeve positioned within the dose dial component. The drive sleeve is configured to drive a rotatable spindle during a dose administration step. The spindle nut is coupled to the spindle and the sprung lock nut is removably coupled to the drive sleeve and rotationally fixed to the housing. In one arrangement, when the dose dial component is rotated to select a dose less than a preselected minimum dose, the sprung lock nut allows the spindle nut to rotate thereby preventing the dose from being administered.

Abstract: The present invention relates to a dose setting mechanism for a drug delivery device and a method of using same. The mechanism comprises a drug delivery device housing, a dose dial sleeve positioned at least partly in the housing and being rotatable during dose setting and dose delivery, a clutch rotatable during dose setting and non-rotatable during dose delivery, and a clutch nut, that is threadedly engaged with the clutch and is splined to the housing to prevent rotation of the clutch nut.

Abstract: An injection device including a drive unit, a delivery unit, a dosing unit, a trigger for triggering an injection, a first coupling mechanism between the drive unit and the delivery unit, and a second coupling mechanism between the dosing unit and the drive unit, wherein the drive unit is tensioned by a rotation of the dosing unit and when the drive unit is tensioned the first coupling mechanism is disengaged and the second coupling mechanism is engaged, and wherein when an injection is triggered first the first coupling mechanism is engaged and then the second coupling mechanism is disengaged. In some embodiments, the device may include a third coupling mechanism which only releases the delivery unit after the engagement and disengagement which follow a triggering.

Abstract: A multiple dose syringe has a first valve defining a first valve opening pressure and a second valve defining a second valve opening pressure. A storage chamber in fluid communication with the second valve stores multiple doses of a substance therein and includes an outlet for dispensing multiple doses of the stored substance therethrough. A compression surface is movable between first and second positions and defines a compression chamber between the compression surface and the first valve. Movement of the compression surface in a direction from the first position toward the second position dispenses substance in the compression chamber through the first valve and out of the syringe. Movement of the compression surface in a direction from the second position toward the first position causes substance to flow from the storage chamber through the second valve and into the compression chamber.

Abstract: A lead screw, a lead screw nut and a drive member are aligned with an axis. A coupling between the lead screw and the lead screw nut allows a helical movement of the lead screw. The drive member is rotationally locked with the lead screw nut. The lead screw is coupled with the drive member to generate a helical movement of the lead screw when the drive member is moved in one axial direction. The coupling is overridden when the drive member is moved in the opposite axial direction. Spline features are arranged on the lead screw in a row parallel to the axis with alternatingly small and large gaps between succeeding spline features. A stop feature of the drive member has a dimension in the direction of the axis which is larger than the small gaps and at most as large as the large gaps.

Abstract: The present invention provides intranasal formulations comprising dexmedetomidine, or a pharmaceutically acceptable salt thereof, and uses thereof.

Abstract: A pump drive and a method thereof to dispense a liquid drug from a container having a plunger piston are disclosed. The pump drive provides a unidirectional clutch provided about a rotational axis which supports centrally a wheel. The clutch has an inner race operably connected to the plunger piston, wherein the clutch is configured to rotate both the inner race about the axis in unison with rotation of the wheel in only a first direction to advance the plunger piston, and to let the wheel rotate relative to the inner race about the axis in a second direction opposite to the first direction without advancing the piston plunger. The drive in one embodiment includes at least one shape memory alloy wire which when excited rotates the wheel in the first rotational direction to advance the piston plunger and dispense the liquid drug from the container.

Abstract: A drive device for advancing an advancing element (2; 33) relative to a housing (1; 30) over a entire advancing distance (G) comprises a tensioning device having a tensioning element (3; 39) for tensioning a spring device (4). A predetermined distance (A) between the tensioning element (39) and the advancing element (33) or between the counter element (7) and the tensioning element (3) that engages with advancing element can be set according to the advancing of the advancing element (2; 33) by a partial advancing distance that is less than the entire advancing distance (G). According to a method for discharging a fluid product from a container (16) via an outlet (17), a plunger (18) is displaced inside the container (16) by means of a drive device provided with an advancing element (2; 33) and with a spring device (4), whereby the spring device (4) is tensioned by a tensioning device according to the advancing of the advancing element (2; 33) by a partial advancing distance.

Abstract: The present invention relates to a drive mechanism for a drug delivery device, comprising a number of mechanically interacting functional components among which at least a piston rod is adapted to transfer thrust to a piston of a cartridge that contains a medicinal product to be dispensed, wherein at least one of the functional components at least in sections comprises a friction-reducing slide coating. In this way, a force level required for dispensing and/or setting of a dose can be effectively reduced.

Abstract: Disclosed herein are cartridge assemblies that include coding features that help dedicate a medicament reservoir to specific injection devices. An exemplary cartridge assembly comprises a cylindrical inner surface for holding medicament and a cylindrical outer surface comprising at its proximal end one or more stops configured as coding elements protruding from the cylindrical outer surface. Each coding element is configured only to engage a corresponding coding feature on a dose setting and delivery mechanism, thereby allowing only the correct cartridge assembly to connect to the dose setting and delivery mechanism.

Abstract: The invention concerns an injection device for apportioning set doses of a drug from a reservoir to a subject. The injection device comprises a housing having an interior thread formed as an outwardly pointing thread carried on an upstanding tower centrally located in the pen shaped device. This outwardly pointing thread forms a first thread connection with the interior thread of the rotatable scale drum. The injection device further comprises a driver for moving the piston rod forward when moved axially. The driver operates the piston rod through a second thread connection having a pitch different than the first thread connection.

Abstract: Methods and devices for micro-dosing a liquid are disclosed herein. According to one embodiment, a method for a time controlled micro-dosing of a liquid from a liquid reservoir includes: receiving the liquid reservoir with a structure wherein the structure is portable; securing the liquid reservoir to the structure; connecting a second end of a drive unit to a piston disposed within the liquid reservoir; activating a drive motor; displacing the drive unit with respect to the structure towards the piston in an axial direction with the drive motor; moving the piston axially within the liquid reservoir; and micro-dosing the liquid from the liquid reservoir.

Abstract: Ampoules for dispensing flowable substances and metering systems incorporating the same are described herein. An ampoule for a flowable substance includes an ampoule body comprising an interior space for receiving the flowable substance and an inner circumferential surface having a guide region and a sealing region. A piston may be disposed in the interior space of the ampoule body such that the piston is slidably displaceable along a direction of displacement. The piston includes at least one sealing element for forming a seal with the inner circumferential surface in a contact zone on the outer circumference of the sealing element. The sealing element has a first compression state when the contact zone is in the guide region and a second compression state when the contact zone is in the sealing region. A second blocking device prevents movement of the contact zone from the sealing region to the guide region.

Abstract: A device for the dosed administration of a fluid product including a housing, a conveying device for the product, a drive element influenced by the selection of a product dose, a coupling input member coupled to the drive element, a coupling output member coupled to the conveying device, a retaining device which maintains the coupling elements in a maintaining position uncoupled from each other, wherein at least one of the coupling elements is displaceable by a coupling movement from the maintaining position into a coupling state, and wherein a driving force of the drive element causes a delivery movement of the conveying device via the coupling elements.

Abstract: An assembly for the administration of a selected dosage of insulin or other medicaments from a cartridge by moving a plug guided in said cartridge, comprises an adapter assembly for adapting cartridges with different dimensions or contents. The adapter assembly comprises a first threaded element threaded with a thread lead and movable in a moving direction to move the plug, and a second threaded element threaded with a thread lead for setting a selected dosage, pivotably screwed to said first threaded element and limiting the movement of said first threaded element, and wherein said thread lead of said first element and said thread lead of said second threaded element are adapted to the dimensions and/or the contents of said cartridge.

Abstract: Various embodiments are directed to a modular valve apparatus. The modular valve apparatus includes a retaining component having an opening on either end. The modular valve apparatus further includes a cap component having a hole bored through. The cap component may be adapted to be coupled with the retaining component. A generally annular spring component may be disposed within the retaining component and seated on a lower end extending axially toward an upper end of the retaining component. A check ball may be disposed within the retaining component and seated on the spring component. The check ball may be adapted to block the opening bored through the cap component while being held in place by the spring component.

Abstract: An assembly for a drug delivery device (1) comprises a housing (5), a rotation member (15), a drive member (16) and at least one correction member (7). The rotation member (15) is adapted to be rotated with respect to the housing (5) in a first rotational direction for delivering a dose of a drug (11). The drive member (16) is coupleable to the rotation member (15) for delivering the dose. In a delivery mode, the drive member (16) and the rotation member (15) are coupled such that the drive member (16) follows rotational movement of the rotation member (15) in the first rotational direction due to mechanical interaction of the rotation member (15) and the drive member (16). In a correction mode, the rotation member (15) and the drive member (16) are decoupled such that the rotation member (15) is rotatable in the first rotational direction with respect to the drive member (16).

Abstract: A medicament dispensing mechanism is disclosed that is configured to eject successive doses of the medicament from a medicament chamber. An embodiment of the dispensing mechanism includes a housing and a plunger rod configured for ejecting the doses of medicament from the chamber. The dispensing mechanism further includes an actuation mechanism that comprises a trigger associated with the housing and having a ready and a fired position with respect thereto. The trigger is configured for manipulation by a user for successive movement in a generally axial dosing motion from the ready position to the fired position in which the trigger is associated with the plunger rod to cause the plunger rod to eject one of the doses of a predetermined volume and a resetting motion from the fired position to the ready position that comprises axial rotation, wherein the trigger is uncoupled from the plunger rod during the resetting motion.

Abstract: The present invention relates to a device for expelling a predetermined quantity of medicament comprising driving means comprising an energy-accumulating member, a nut, and a driver for driving a pressure means; and activation means for activating said driving means wherein said pressure means comprises a movable wall part arranged inside a 2 container and a threaded plunger rod arranged to interact with said driving means for pushing said movable wall part forwardly, and wherein said activation means comprises a manually operated push button arranged on the front end of the device for promoting an ergonomic handling of the device and wherein said activation means are capable of interacting with said driving means in a stepwise mode; such that each time said push button is depressed said pressure means moves an step exerting pressure on the medicament inside the container and expelling a predetermined quantity of the medicament through the opening.