Means For Intermixing Liquid With Solid Or Different Liquid Patents (Class 604/82)
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Patent number: 5578005Abstract: We disclose apparatus and methods for delivering for patient infusion or other use two or more fluids either sequentially or simultaneously. The apparatus has a fluid delivery compartment containing a first infusion fluid, a flexible membrane, and an openable bag containing a second infusion fluid. An attached gas reaction compartment contains chemical reactants which, when combined, react to evolve gas. The gas expands a gas expansion chamber causing the membrane to move into the fluid delivery compartment, displacing the first infusion fluid. The membrane eventually contacts and compresses the openable bag. Pressure from the membrane causes the bag to open and discharge its contents out of the infusion device.Type: GrantFiled: September 16, 1994Date of Patent: November 26, 1996Assignee: River Medical, Inc.Inventors: Gregory E. Sancoff, Mark C. Doyle, Frederic P. Field
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Patent number: 5574075Abstract: The invention relates to a material in the form of a three-dimensional conglomerate of polymer particles which is used as a starting material for the preparation of bone cement. The conglomerate is a solid with a uniform pore system and is prepared by bonding the polymer particles to one another at their points of contact or connecting them at their surfaces. After addition of the monomer the material is prepared to a self-curing bone cement and mixed.Type: GrantFiled: June 8, 1993Date of Patent: November 12, 1996Inventor: Klaus Draenert
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Patent number: 5569191Abstract: The invention concerns a device for the preparation of a medicinal solution from two components, one of which is in powder, lyophilisate or liquid form and the other a dilutant or a liquid solvent. These components respectively are charged in a rear container (11) and a front container (13), each of which has an opening closed off by a stopper-piston-dish, which is axially movable. Both these stopper-piston-dishes (19, 24) are connected by a conveyance shaft (15) adapted to ensure a rigid, tight and sterile coupling between the two stopper-piston-dishes (19, 24) when the device (10) is in a charging position, and to define a channel between both these containers (11, 13) when the device is in a position of use.Type: GrantFiled: July 19, 1994Date of Patent: October 29, 1996Inventor: Gabriel Meyer
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Patent number: 5562616Abstract: A method and apparatus for preparing a binary liquid, highly toxic cancer treatment pharmaceutical for administration to a patient from an I.V. bag is disclosed. Liquid components of the pharmaceutical are furnished in septum-sealed vials which are mixed in a syringe structure formed by a body having a mixing chamber in fluid communication with first and second ports. The vials are attached to the body at the first port, their septum is pierced, and a normally closed valve between the first port and the chamber is opened so that the liquid components flow along a sealed path into the chamber to prevent contact between the components and the surrounding environment. The I.V. bag is attached to the body at the second port and is pierced by a needle in response to movement of the bag towards the syringe body. This movement is used to open a valve between the second port and the chamber so that the mixed pharmaceutical can be flowed along a sealed path into the I.V.Type: GrantFiled: March 1, 1995Date of Patent: October 8, 1996Assignee: Habley Medical Technology CorporationInventors: Terry M. Haber, William H. Smedley, Clark B. Foster
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Patent number: 5542760Abstract: A device and method for filling a conventional disposable plastic syringe with a mixture of insulins. The mixing device includes a pair of disposable cartridge assemblies each containing a different type of medication to be mixed in the syringe and a pair of medication dispensing mechanisms for dispensing the medication out of a respective cartridge. Each dispensing mechanism permits one to specify the dose of medication to be dispensed and drives a plunger into its respective cartridge a specific distance based on the specified dose. The mixing device also includes a syringe holder assembly that holds a syringe until a mixed dose of medication must be dispensed and provides proper alignment of the cannula of the syringe with each cartridge assembly during mixing.Type: GrantFiled: September 26, 1995Date of Patent: August 6, 1996Assignee: Becton Dickinson and CompanyInventors: Lawrence H. Chanoch, John B. Wilson
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Patent number: 5540667Abstract: A needle guard assembly for a prefilled emergency syringe includes a cylindrical sidewall which extends coaxially with the syringe needle. The sidewall is joined to the syringe housing by spin welding or sonic welding an annular fusible portion that extends axially rearward from an annular flange on the base of the sidewall to contact the front wall of the housing. The sidewall is joined to the housing so that an annular clearance space for the hood is maintained between the hub and the sidewall guard.Type: GrantFiled: February 6, 1995Date of Patent: July 30, 1996Assignee: Abbott LaboratoriesInventor: John C. Tanner, II
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Patent number: 5531683Abstract: A device for intermixing a first component, such as a parenteral fluid with a second component, such as an immobilized drug carried by a scaffold to form a beneficial agent which, following the mixing step, can be dispensed directly from the device for infusion into a patient. The device includes novel mechanisms for mateably interconnecting a container, such as a glass vial containing the first component with a housing having a fluid outlet which houses a sealed container containing the second component, and then for controllably mixing the components under sterile conditions to form an injectable solution which is automatically dispensed through the fluid outlet of the device.Type: GrantFiled: July 6, 1994Date of Patent: July 2, 1996Assignee: Science IncorporatedInventors: Marshall S. Kriesel, Thomas N. Thompson
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Patent number: 5520658Abstract: A dispensing device for dispensing at least two fluids comprises a housing (12,22) of a pistol-like configuration having an integral handle (50), in which a spring-biased trigger (60) is received. Within the housing (12,22) of the dispensing device (10), two syringes (80,81) are received and fixated, which syringes contain respective fluids to be accurately dispensed. Provided a cover (22) of the housing is closed, the motion of the trigger (60) relative to the handle (50) is transmitted to a toothed rack which cooperates with a propeller body (70) in a ratchet-like manner. The ratchet-like cooperation allows a uni-directional motion of the propeller body (70) and prevents a motion of the propeller body (70) in the opposite direction.Type: GrantFiled: December 12, 1994Date of Patent: May 28, 1996Assignee: E. R. Squibb & Sons, Inc.Inventor: Niels E. Holm
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Patent number: 5505704Abstract: A hand-held dual liquid medication injector have dual, bi-directional dosage metering mechanisms for permitting a variable dosage amount for each cartridge of liquid medication. The medications are mixed within a manifold having a valved mixing chamber and are injected via a single cannula. The mixing chamber is valved such that backflow of mixed or unmixed medications into the cartridges is prevented. An injection mechanism, independent of the metering mechanism, loads and injects the liquid medication. In one embodiment, downward movement of the injection mechanism during injection is translated into horizontal movement by the plunger mechanism. In another embodiment, a power-assisted plunger mechanism accomplishes injection.Type: GrantFiled: June 1, 1995Date of Patent: April 9, 1996Assignee: Eli Lilly and CompanyInventors: Gerhard E. F. Pawelka, Christopher J. Stringer, Matthew Marsh, David L. Karshmer, Christopher O. Lada, Stephen J. Schoenberg
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Patent number: 5492531Abstract: A stomach lavage apparatus for the introduction of a highly absorbent antidote solution, such as activated charcoal, into the gastric cavity for the purpose of absorbing or otherwise counteracting a digested poison present therein, is described. The lavage apparatus is a completely closed system so that the antidote solution is never exposed to the atmosphere and there is no risk of spilling the antidote solution. The present invention thus comprises a flexible container for the antidote solution, the container being connectable to a lavage conduit leading into the gastric cavity by threading the container into a fitting provided with an internal spike. This causes the spike to puncture a rupturable seal provided in an exit port of the container, and the container is then squeezed to express the antidote solution therefrom and into the lavage conduit for introduction into the gastric cavity.Type: GrantFiled: November 21, 1994Date of Patent: February 20, 1996Assignee: Ethox CorporationInventors: Gregory Post, Matthew Alesse, Edwin T. Bean, Jr.
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Patent number: 5489266Abstract: A syringe assembly includes a substantially cylindrical syringe barrel and a plunger assembly. The plunger assembly includes a distally disposed flow channelizer and a proximally disposed stopper releasably engaged with one another. The stopper includes an aperture engageable with the distal end of a plunger rod. The flow channelizer includes flutes for accommodating an outflow of vapor during lyophilization and to enable efficient mixing of a lyophilized medication and a diluent. Liquid medication in the syringe chamber is lyophilized and a vacuum is applied to the syringe barrel. The plunger assembly then is urged distally into sealing engagement with the syringe barrel. A plunger rod is engaged with the stopper, and is moved proximally to simultaneously separate the stopper from the flow channelizer and to draw diluent into the chamber for reconstituting the previously lyophilized medication.Type: GrantFiled: January 25, 1994Date of Patent: February 6, 1996Assignee: Becton, Dickinson and CompanyInventor: Jean P. Grimard
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Patent number: 5487750Abstract: An integrated nursing bottle and liquid medication dispensing apparatus enables precise and independent control of both the rate of administration of the medication, and the amount by which it is diluted before reaching the infant's mouth. A preferred embodiment utilizes a deformable plastic bag with a sleeve for receiving a syringe that permits mixing of medicine and a diluting fluid in the nipple area of the bottle. The present invention also includes a recessed bottle bottom which permits easier one-handed administration of the feeding bottle and medication to the infant.Type: GrantFiled: September 29, 1994Date of Patent: January 30, 1996Inventors: Mark T. Burchett, Lori W. Burchett
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Patent number: 5484410Abstract: An apparatus for separately storing a first component, such as a drug and for mixing this first component with a second component, such as a sterilized diluent, to form a beneficial agent which can be delivered to a patient from the container containing the second component. The device includes novel means for interconnecting a container, such as a glass vial containing a first component, such as a drug, with a second container such as a flexible bag containing the second component such as a parenteral liquid, and then for controllably ejecting the first component from the glass vial so that it will fall by force of gravity into the second container whereby the first and second components will thoroughly mix under sterile conditions.Type: GrantFiled: December 22, 1994Date of Patent: January 16, 1996Assignee: Science IncorporatedInventors: Marshall S. Kriesel, Thomas N. Thompson
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Patent number: 5478337Abstract: An outer tube having a double-ended needle accommodated therein upwardly and downwardly slidably is hermetically, removably but fixedly joined to an opening seal portion of a dissolving liquid container. An inner tube having a medicine-containing vial accommodated therein in an inverted state is joined to an upper end of the outer tube so as to be movable from a joined position of shallow fit to a joined position of deep fit. The joint between the outer and inner tubes is provided with a seal ring for holding the interior of the tubes airtight and a restraining mechanism for holding the inner tube in the joined position of shallow fit. The medicine container thus constructed is excellent in impact resistance and shakeproofness for transport and storage, usable by a facilitated mixing procedure for preparing a medicinal solution, simple in overall structure and disposable as separated into components after use.Type: GrantFiled: December 20, 1993Date of Patent: December 26, 1995Assignees: Otsuka Pharmaceutical Factory, Inc., Takeda Chemical Industries, Ltd.Inventors: Hideshi Okamoto, Yoshiki Maesaki, Hidekatsu Shoji, Isamu Tateishi, Takayuki Hagiwara, Tetsuya Hatono
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Patent number: 5478311Abstract: A pill crushing/dispensing device includes a plunger having a handle at one end and an abraded surface at the other, and a barrel/spoon unit which has an opposing abraded surface in its bottom interior so that a pill is crushed between the abraded surfaces as the plunger is advanced into the barrel. After the pill is crushed between the abraded surfaces, the plunger is removed and a fluid added to create a suspension of pill crushings which may then be orally administered by tipping the barrel/spoon unit to a generally horizontal position so that the fluid flows into the spoon unit which may then itself be inserted into a patient's mouth. In alternative embodiments, a central air passageway extends the length of the plunger unit to facilitate the flow of air to and from an air pocket between the abraded surfaces to facilitate the easy movement of the plunger within the closed barrel. A cap may be used to selectively seal the passageway.Type: GrantFiled: June 23, 1994Date of Patent: December 26, 1995Inventor: Jeffrey D. Klearman
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Patent number: 5474540Abstract: A fluid delivery device for delivery and mixing of fibrin glue components at a treatment site during surgery includes a slidable sleeve for controlling interaction of fluid dispensed from a pair of adjacent tubes. A pair of syringes are attached to a fluid separation control attachment which allows the fluids from each of the syringes to be forced into the adjacent tubes. When the fluids exit the free ends of the adjacent tubes, they interact and mix when the slidable sleeve thereon is in one position, but are inhibited from interacting and mixing when the slidable sleeve is in another position.Type: GrantFiled: March 25, 1994Date of Patent: December 12, 1995Assignee: Micromedics, Inc.Inventors: Curtis Miller, Brian McLevish
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Patent number: 5472422Abstract: A method for manufacturing an injectable preparation of a pharmaceutically active agent suitable for storage in a dual-chamber injection cartridge. A dual chamber injection cartridge is provided, including: a barrel; a front chamber for a solid component; a rear chamber for a liquid component; a displaceable front piston separating the front and rear chambers; a closure sealing the front end of the barrel; and a constriction between the front and rear ends of the barrel. The constriction has a non-circular cross-section and an openable bypass connection permitting passage of liquid between the rear and front chambers. Prior to opening the bypass connection, the front piston is positioned between the constriction and the rear end of the barrel. The constriction resists displacement of the front piston in a direction of the front end of the barrel when the piston is in the vicinity of the constriction.Type: GrantFiled: February 24, 1994Date of Patent: December 5, 1995Assignee: Pharmacia AktiebolagInventor: Olle Ljungquist
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Patent number: 5472022Abstract: An injection pen apparatus (30) for medicament injection including a medicament cartridge assembly (31) formed to receive and contain a medicament therein. A holding sleeve (34) is provided which is dimensioned to receive the medicament cartridge assembly (31) therein which mates with a solution transfer device (35) including an axially movable displacement rod (36). The injection pen apparatus (30) further includes a coupling mechanism (37) removably coupling the solution transfer device (35) to both a plunger (32) slidably movable in the cartridge (33) and to the holding sleeve (34). A sleeve mounting assembly (40) of the coupling mechanism (37) removably mounts the coupling mechanism to the holding sleeve (34).Type: GrantFiled: November 2, 1993Date of Patent: December 5, 1995Assignee: Genentech, Inc.Inventors: Peter Michel, Robert S. Freeman, James Q. Oeswein
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Patent number: 5472421Abstract: A pill crushing syringe is disclosed which includes a barrel and a plunger, with abraded surfaces on each so that a pill placed in the barrel is crushed as the plunger advances within the barrel. The barrel has an aperture located near the closed end with a catheter connected around and extending from the aperture. The plunger has a sealing gland to provide an airtight seal with the barrel so that liquid may be drawn into the barrel through the aperture by withdrawing the plunger from the barrel to thereby suspend the crushed pill in the liquid, and the suspension may be flushed from the barrel by thereafter advancing the plunger into the barrel. In an alternative embodiment, a bi-level barrel has an aperture in spaced relation to the closed end forming a pocket wherein the crushed pill ingredients accumulate. The pocket at the closed end and the separation between the aperture and the barrel closed end helps prevent the medication from escaping the barrel via the catheter prior to aspiration.Type: GrantFiled: December 13, 1994Date of Patent: December 5, 1995Assignee: Lake Medical Products, Inc.Inventors: Jeffrey D. Klearman, Matt Roth, Jerry Roth, Robert Bronson
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Patent number: 5464393Abstract: A pill crushing syringe is disclosed which includes a barrel and a plunger, with abraded surfaces on each so that a pill placed in the barrel is crushed as the plunger advances within the barrel. The barrel has an aperture located near the closed end with a catheter connected around and extending from the aperture. The plunger has a sealing gland to provide an airtight seal with the barrel so that liquid may be drawn into the barrel through the aperture by withdrawing the plunger from the barrel to thereby suspend the crushed pill in the liquid, and the suspension may be flushed from the barrel by thereafter advancing the plunger into the barrel. In an alternative embodiment, a bi-level barrel has an aperture in spaced relation to the closed end forming a pocket wherein the crushed pill ingredients accumulate. The pocket at the closed end and the separation between the aperture and the barrel closed end helps prevent the medication from escaping the barrel via the catheter prior to aspiration.Type: GrantFiled: June 23, 1994Date of Patent: November 7, 1995Assignee: Lake Medical Products, Inc.Inventors: Jeffrey D. Klearman, Jeffrey J. Bierman, Eli Schachet
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Patent number: 5462526Abstract: A flexible, sterile container is provided for sterile storing and mixing of medicaments and liquids which includes a shell with at least one compartment. At least one sterile liquid-containing pouch is in one of the compartments, and a medicament is in the compartment with the pouch or is in a different compartment. The liquid and medicament are mixed together by squeezing the shell and pouch to rupture the pouch to release the liquid for mixing with the medicament just prior to dispensing the mixture.Type: GrantFiled: September 15, 1993Date of Patent: October 31, 1995Assignee: McGaw, Inc.Inventors: Ward W. Barney, Steven L. Smith
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Patent number: 5443454Abstract: An embolectomy catheter containing a lumen for the introduction of a liquid substance and provided in the distal end thereof with spinning means for extruding said liquid substance in the form of a filamentous embolic material.Type: GrantFiled: December 9, 1993Date of Patent: August 22, 1995Assignee: Terumo Kabushiki KaishaInventors: Susumu Tanabe, Fumihisa Hirose
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Patent number: 5433705Abstract: Anti-infection catheter arrangement comprising a catheter which has a rigid or flexible catheter tube with a connection piece at the distal end, characterized by a filling and suction device which can be attached to the connection piece and one or more active principle reservoirs with a total volume equal to the capacity of the catheter, possibly in addition the volume of intermediate pieces, in particular a three-way valve. This volume is entirely filled and at least one of the active principle reservoirs is filled with a substance containing at least an antibiotic agent or a chemotherapeutic agent or an antiviral agent, preferably aminoglycoside, in particular gentamycin, in at least a minimal effective concentration.Type: GrantFiled: April 30, 1993Date of Patent: July 18, 1995Inventors: Marion Giebel, Willehad Boemke, Ulo Palm
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Patent number: 5425580Abstract: A dosage form for micro bubble echo contrast media which comprises a syringe (6) and a mixing chamber (1) which is connected thereto and contains a predetermined amount of gas, plus a second syringe is described. The novel dosage form allows easy, standardised preparation of echo contrast media and gives high contrast (FIG. 3).Type: GrantFiled: August 2, 1994Date of Patent: June 20, 1995Assignee: Byk Gulden Lomberg Chemische Fabrik GmbHInventor: Klaus-Dieter Beller
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Patent number: 5423752Abstract: A variable proportion dispenser (2c) includes a housing (12c) which houses two pharmaceutical cartridges (6b). A reciprocating drive assembly includes drive stems (36c) extending from the pistons (46b) of each cartridge, a limit guide (76c) removably mounted to the housing, and a sliding body (66e, 300) mounted to the housing through the limit guide. Two one-way drivers (326) and threaded dosage adjusters (60c) are carried by the sliding body. Each one-way driver drives the drive stem into the cartridge through a drive surface to provide a range of dose selections. The user can thus control the amount and proportion of each pharmaceutical dispensed during each delivery stroke for each dispensing cycle. The housing is separable from the remainder of the dispenser, preferably using a cartridge release assembly (302), to allow spent cartridge to be replaced.Type: GrantFiled: July 31, 1992Date of Patent: June 13, 1995Assignee: Habley Medical Technology CorporationInventors: Terry M. Haber, Clark B. Foster, William H. Smedley
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Patent number: 5409141Abstract: A drug delivery system including a drug container containing a dose of a dry drug and having a mouth portion sealed by a sealing member including a packing, a spherical closing member and a holding member; a solvent container containing a solvent and having at either ends first and second openings also sealed by a sealing member at least one sealing member for the first opening of the solvent container including a packing, a spherical closing member and a holding member; and a fluid-communication member arranged between the mouth portion of the drug container and the first opening of the solvent container.Type: GrantFiled: March 4, 1993Date of Patent: April 25, 1995Assignee: Nissho CorporationInventors: Toshihiro Kikuchi, Hitoshi Futagawa, Koji Ikeda
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Patent number: 5405343Abstract: The invention is directed to a blood bag system for blood products comprising a bag (3) and at least one tubing (11) connected thereto, the system being made of at least partly transparent plastics material, wherein photoactive substances (31) may be enclosed in a closed-off section (A) of the tubing (11) of the ready-for-use system, which may be handled individually as an independent unit. Every blood bag system of this kind is adapted to be combined with another blood bag system, which may comprise one or several bags (3, 5, 7, 9) and may likewise be handled as an independent unit, by interconnecting both systems.Type: GrantFiled: September 2, 1993Date of Patent: April 11, 1995Assignee: Blutspendedienst der Landesverbande des Deutschen Roten Kreuzes Niedersachsen, Oldenburg und Bremen G GmbHInventor: Harald Mohr
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Patent number: 5397303Abstract: A device is disclosed which provides direct and effective incorporation of material (such as medicine) from a separate container into the contents of a liquid dispensing device. The device has a hollow sleeve extending outwardly, an openable closure, a securing member which engages a mating member on the container, and a conduit (such as a needle) to provide fluid communication between the device and the container, with the fluid communication occurring upon attachment of the container to the device. The device can also provide for attaching the separate container to the dispensing device but without initially establishing liquid communication between the two.Type: GrantFiled: August 6, 1993Date of Patent: March 14, 1995Assignee: River Medical, Inc.Inventors: Gregory E. Sancoff, Mark C. Doyle, Frederic P. Field
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Patent number: 5393497Abstract: A device (2) used to transfer the liquid contents (156) of a glass ampule (8) to a vial (10) includes a telescoping ampule body (12, 14) defining a collapsible, substantially air-tight region (22) within which the ampule is housed, which collapses when one part (12) is threaded onto the other part (14). This collapse increases the pressure within the collapsible region housing the ampule. The ampule is broken within the region, such as at the end of the collapsing of the telescoping members by snapping off the tip (64) of the ampule and breaking the base (48, 53) of the ampule. When used with a vial, a vial (10) is mounted to the ampule body via a vial body (80, 92). A vial spike (120) passes through the vial septum (128). The ampule body and the vial body defines a flow path (74, 100) between the vial spike and the ampule region. Once the flow path is open, the liquid from the ampule within the region flows along the flow path and into the vial because of the pressure created within the region.Type: GrantFiled: January 24, 1994Date of Patent: February 28, 1995Assignee: Habley Medical Technology CorporationInventors: Terry M. Haber, William H. Smedley, Clark B. Foster
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Patent number: 5385546Abstract: An apparatus for separately storing a first component, such as a drug and for mixing this first component with a second component, such as a sterilized diluent, to form a beneficial agent which can be delivered to a patient from the container containing the second component. The device includes novel means for interconnecting a container, such as a glass vial containing a first component, such as a drug, with a second container such as a flexible bag containing the second component such as a parenteral liquid, and then for mixing the components under sterile conditions.Type: GrantFiled: February 1, 1993Date of Patent: January 31, 1995Assignee: Science IncorporatedInventors: Marshall S. Kriesel, Thomas N. Thompson
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Patent number: 5385564Abstract: A system for packaging and using granulated solid dialysate concentrate. A bag is constructed to hold granulated or powder concentrate, having a V-shaped bottom with an access port in the bottom. Water is flowed through the access port and into the bag using suitable water control means. The incoming water lifts and suspends the granules or powder in a turbulent flow, thereby filling the container simultaneous with dissolving the granules or powder. The water with dissolve concentrate then constitutes the dialysis solution and is ready for use or transfer to a dialysate delivery machine.Type: GrantFiled: October 5, 1992Date of Patent: January 31, 1995Assignee: Fresenius USA, Inc.Inventors: Glenn L. Slater, Jerry Woods, Steve Alford, Dave Updyke, Rick Methe
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Patent number: 5385545Abstract: An apparatus for separately storing a first component, such as a drug and for mixing this first component with a second component, such as a sterilized diluent, to form a beneficial agent which can be delivered to a patient from the container containing the second component. The device includes novel means for interconnecting a container, such as a glass vial containing a first component, such as a drug, with a second container such as a flexible bag containing the second component such as a parenteral liquid, and then for mixing the components under sterile conditions.Type: GrantFiled: June 24, 1992Date of Patent: January 31, 1995Assignee: Science IncorporatedInventors: Marshall S. Kriesel, Thomas N. Thompson
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Patent number: 5383906Abstract: An integrated nursing bottle and liquid medication dispensing apparatus enables precise and independent control of both the rate of administration of the medication, and the amount by which it is diluted before reaching the infant's mouth. The preferred embodiment utilizes a syringe mounted coaxially within a baby bottle, allowing one-hand operation.Type: GrantFiled: May 12, 1993Date of Patent: January 24, 1995Inventors: Mark T. Burchett, Lori W. Burchett
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Patent number: 5380315Abstract: An apparatus is provided for separately storing and selectively mixing a first component, which is in a liquid form, and a second component. The apparatus is formed of a first container made of a flexible material, having a communication mouth with an isolator and adapted to store the first component therein, a supporting case connected to the communication mouth, a second container having a mouth portion held in the case and a plug fitted in the mouth portion and adapted to store the second component, and a hollow, inflexible communication device capable of penetrating through the isolator and the plug. The communication device is accommodated in the first container and is attached to the communication mouth movably therein.Type: GrantFiled: January 26, 1993Date of Patent: January 10, 1995Assignee: Material Engineering Technology Laboratory IncorporatedInventors: Keinosuke Isono, Tatsuo Suzuki
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Patent number: 5378232Abstract: Disclosed is apparatus for administration of a drug in active form, which includes means defining a prodrug reaction zone including an immobilized enzyme for modifying chemically a prodrug to a physiologically compatible, physiologically active drug form, means in communication with the reaction zone for establishing parenteral access to the body of a patient, and means for transporting a prodrug through the reaction zone at a rate sufficient to convert the prodrug to the active drug form and then into the body of a patient.Type: GrantFiled: August 28, 1991Date of Patent: January 3, 1995Assignee: Orion Therapeutic Systems, Inc.Inventors: Thomas G. Easton, Edward Reich
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Patent number: 5378226Abstract: A system for impregnating and dispensing a swab. An outer bag is provided having at least one swab and a burst pouch located therein. The burst pouch is opened within the bag while the bag is sealed, impregnating the swab before its removal. The bag is then opened, and the impregnated swab is removed through an access opening in the bag. The access opening is located so that the bag may be lain horizontally without liquid in the bag spilling from the bag. The pouch is oriented in the bag to be in proximity to the absorbent head of the swab.Type: GrantFiled: May 19, 1993Date of Patent: January 3, 1995Assignee: Sage Products, Inc.Inventors: Paul H. Hanifl, Lawrence G. Ponsi, John Posey
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Patent number: 5376072Abstract: A pill crushing syringe includes a barrel and a plunger, with abraded surfaces on each so that a pill placed in the barrel is crushed as the plunger advances within the barrel. The barrel has an aperture located near the closed end with a catheter connected around and extending from the aperture. The plunger has a sealing gland to provide an airtight seal with the barrel so that liquid may be drawn into the barrel through the aperture by withdrawing the plunger from the barrel to thereby suspend the crushed pill in the liquid, and the suspension may be flushed from the barrel by thereafter advancing the plunger into the barrel.Type: GrantFiled: December 15, 1993Date of Patent: December 27, 1994Assignee: Lake Medical Products, Inc.Inventors: Jeffrey D. Klearman, Jeffrey J. Bierman, Eli Schachet
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Patent number: 5376079Abstract: A dispensing device for dispensing at least two fluids comprises a housing (12,22) of a pistol-like configuration having an integral handle (50), in which a spring-biased trigger (60) is received. Within the housing (12,22) of the dispensing device (10), two syringes (80,81) are received and fixated, which syringes contain respective fluids to be accurately dispensed. Provided a cover (22) of the housing is closed, the motion of the trigger (60) relative to the handle (50) is transmitted to a toothed rack which cooperates with a propeller body (70) in a ratchet-like manner. The ratchet-like cooperation allows a uni-directional motion of the propeller body (70) and prevents a motion of the propeller body (70) in the opposite direction.Type: GrantFiled: May 25, 1993Date of Patent: December 27, 1994Inventor: Niels E. Holm
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Patent number: 5374248Abstract: A manifold has a plurality of stopcocks wrapped in a flexible cellular material saturated with an antiseptic liquid and contained in a housing. Each control element of the stopcocks is removable and can be rotationally integrated with a head portion of a stopcock via a shaped male part. The shaped male part engages a female cavity of a matching shape through openings provided in the housing and in the cellular material opposite the stopcocks. Markings showing the position of the stopcocks are visible from the exterior of the housing when the element is withdrawn.Type: GrantFiled: December 28, 1992Date of Patent: December 20, 1994Assignee: Cair L.G.L.Inventor: Georges A. Lopez
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Patent number: 5374249Abstract: A pharmaceutical mixing container for storing a liquid having at least two factions which tend to separate during storage. A housing has an inner volume and is closed at one end by a septum arrangement and at another end by a combination sealing and pumping member. The combination sealing and pumping member has an integrally formed outer diaphragm element forming a diaphragm chamber with the inner structure of this element, and a plurality of fluid channels extending through the sealing and pumping element from the diaphragm chamber to the surface facing the inner volume of the container. A driving member assembly is coupled to the diaphragm element to enable this element to be extended and retracted by manipulating the driving element assembly inwardly and outwardly of the container.Type: GrantFiled: September 23, 1992Date of Patent: December 20, 1994Assignee: Habley Medical Technology CorporationInventors: Terry M. Haber, Clark B. Foster, William H. Smedley
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Patent number: 5368563Abstract: An improved sprayer assembly for delivery of physiologic glue, including fibrin glue, is disclosed. The sprayer assembly is comprised of at least one female receptacle rigidly affixed to a base member and a sprayer member having at least one atomizing ejection port on an external surface opposing the base member. Within the sprayer member, a system of fluid channels permits each reservoir to be emptied into a well from angular connecting channels, which causes enhanced turbulence within each well. A vortex is created which propagates through an exit port and down an exit channel, causing each solution to exit the sprayer member at each ejection port in a swirling pattern. The spray patterns emitted from each syringe or reservoir overlap, causing droplets of solution to contact one another and commence a clotting reaction at a wound surface.The sprayer assembly is joined to a conventional syringe, a catheter or other solution reservoir.Type: GrantFiled: November 8, 1993Date of Patent: November 29, 1994Assignee: Micromedics, Inc.Inventors: Alan Lonneman, Curtis H. Miller
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Patent number: 5364386Abstract: An infusion unit has a flexible container and an open-ended pipe having a first opening in communication with the container and a second opening axially opposite the first. The pipe has smaller and larger diameter portions with the smaller diameter portion located between the second opening and the larger diameter portion. An axially moveable plug is receivable within the smaller diameter portion to seal the second opening of the pipe. An axially moveable engaging member with an end for engaging the plug and a needle at the opposite end for piercing the stopper of a vial. The plug may be pushed by the engaging member from the smaller diameter section to the larger diameter section so as to permit flow through the pipe between the first and second openings to the vial and container.Type: GrantFiled: May 5, 1993Date of Patent: November 15, 1994Assignee: Hikari Seiyaku Kabushiki KaishaInventors: Hisaji Fukuoka, Tatsuji Yoshida, Suminori Kobayashi, Toshikazu Sakurai
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Patent number: 5352191Abstract: A transfusion device comprising a flexible vessel containing a solvent fluid, a plugged drug container containing a drug, and a communicating portion for communicating the vessel and the container with each other, the communicating portion comprising a communicating passage disposed at a top portion of the flexible vessel and having the drug container partially or wholly fitted therein, a plugged mouth portion of the container facing downward, a membrane disposed in the communicating passage for closing the passage, and a particular puncturing needle unit mounted in the communicating passage for enabling the vessel and container to communicate with each other. When the puncturing needle unit is pressed externally through the flexible vessel, the needle breaks the membrane and the plug member of the drug container to enable the vessel and container to communicate with each other.Type: GrantFiled: October 14, 1992Date of Patent: October 4, 1994Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Seizo Sunago, Osamu Aoki
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Patent number: 5352036Abstract: A pharmaceutical mixing container for storing a liquid having at least two factions which tend to separate during storage. A housing has an inner volume and is closed at one end by a septum arrangement and at another end by a slidable sealing member. A magnetizable mixing member is located within the housing and contacts the liquid faction of the pharmaceutical contained within the housing. An external magnet produces a magnetic field which extends within the inner volume and interacts with the mixing element. By manually translating the magnet along the axis of the housing, the mixing member is forcibly moved through the liquid causing turbulent waves which provide thorough admixing for the pharmaceutical constituents. By controlling the pace of movement of the magnet, thorough admixing is provided without causing mechanical damage to delicate constituents, such as crystalline factions found in NPH type insulin.Type: GrantFiled: July 12, 1993Date of Patent: October 4, 1994Assignee: Habley Medical Technology CorporationInventors: Terry M. Haber, Clark B. Foster, William H. Smedley
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Patent number: 5342346Abstract: A fluid container comprises a drug container, a deformable solvent container, a double-pointed hollow needle having a sharp piercing edge at each end and being arranged between the drug container and the solvent container, a guide capsule with a cap rotatably mounted thereon, and a means for converting rotary motion of the cap to a linear motion of the drug container to push the drug container toward the solvent container in cooperation with the cap and the guide capsule so that a fluid communication is made between two containers through the needle.Type: GrantFiled: April 9, 1993Date of Patent: August 30, 1994Assignee: Nissho CorporationInventors: Minoru Honda, Masanobu Iwasa, Tetuzi Miyamoto, Koji Ikeda, Toshihiro Kikuchi
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Patent number: 5336180Abstract: An apparatus for controllably intermixing two or more components in a sterile, closed environment to produce a flowable substance and then for expelling the flowable substance from the apparatus at a precisely controlled rate. The apparatus is particularly useful for medical applications and includes a dispenser portion with its own stored energy element provided in the form of an elastomeric membrane and a coupling mechanism for coupling a drug vial to the dispenser portion for controlled mixing a medicament contained within the drug vial with a diluent stored within the dispenser portion of the apparatus via a sterile pathway.Type: GrantFiled: April 26, 1993Date of Patent: August 9, 1994Assignee: Science IncorporatedInventors: Marshall S. Kriesel, Thomas N. Thompson
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Patent number: 5330426Abstract: A device for intermixing a first component, such as a parenteral fluid with a second component, such as an immobilized drug carried by a scaffold to form a beneficial agent which, following the mixing step, can be dispensed directly from the device for infusion into a patient. The device includes novel mechanisms for mateably interconnecting a container, such as a glass vial containing the first component with a housing having a fluid outlet which houses a sealed container containing the second component, and then for controllably mixing the components under sterile conditions to form an injectable solution which is automatically dispensed through the fluid outlet of the device.Type: GrantFiled: August 13, 1992Date of Patent: July 19, 1994Assignee: Science IncorporatedInventors: Marshall S. Kriesel, Thomas N. Thompson
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Patent number: 5328462Abstract: Methods and apparatus are provided for mixing and dispensing multi-component compositions. The preferred embodiment utilizes a syringe barrel as a mixing chamber and for dispensing of the mixed components. A mixer element, preferable including a paddle member and finger grip means for rotating the paddle member, is provided for insertion into the syringe barrel to effect the desired mixing. A scraper element is used to scrape mixed components from the mixer element so as to retain the mixed components within the syringe barrel upon removal of the paddle member after mixing is completed. Mixing is preferably performed with the multiple components placed in side-by-side orientation within the syringe barrel rather than one on top of another.Type: GrantFiled: September 3, 1993Date of Patent: July 12, 1994Assignee: Ultradent Products, Inc.Inventor: Dan E. Fischer
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Patent number: 5322510Abstract: Injection apparatus for injecting at least two components to be brought into reaction with one another, comprising a hollow injection needle that can be charged by a plurality of syringe coupling connections corresponding in number to the number of components, preferably for endoscopic purposes and fashioned displaceable in a catheter on the basis of a grip member, whereby the syringe coupling connections are provided at the catheter in this case, characterized in that the components can be supplied to the injection needle (3) through a corresponding plurality of hoses (4, 5; 17) preferably proceeding through the catheter (1) and respectively connected to one of the syringe coupling connections (6, 7) in the grip member (2), whereby the components discharge in a common plane (30) wherein the reaction of the components is initiated.Type: GrantFiled: September 19, 1991Date of Patent: June 21, 1994Assignee: Andreas LindnerInventors: Andreas Lindner, Ingolf M. Wechler
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Patent number: RE34845Abstract: A hypodermic syringe has a generally cylindrically tubular body extending along an axis and having an axial front end formed with a radially outwardly projecting annular bead, a piston axially displaceable in the body, a plug having a rearwardly directed flange fitting complementarily over the front end of the body at the bead and forwardly blocking the body, and a flat soft seal ring compressed axially between the plug and the front end of the body. The body has a rear end provided with a finger-rest crosspiece and the piston is provided with a plunger projecting axially out the rear end past the crosspiece.Type: GrantFiled: December 2, 1993Date of Patent: January 31, 1995Assignee: Arzneimittel GmbH Apotheker Vetter & Co.Inventors: Helmut Vetter, Peter Geprags