Abstract: A device for application of material to a surface, for example, biocompatible material to a tissue surface in a medical or clinical setting, is adapted to receive one or more biocompatible materials and one or more sources of pressurized medical gas, and to deliver these biocompatible materials via the medical gas(es) to a tissue surface or other surface. A regulation system controls flow of medical gas at a variety of pressures, and flow of biocompatible agent or agents, allowing agents to be sprayed or otherwise deployed onto a tissue surface. Switching apparatus operably connected to the regulation system directs a set of preset treatment positions allowing sequential application of biocompatible materials under various conditions in conjunction with an overall treatment protocol. The device can be used to apply a photoinitiating primer and polymeric sealant to a tissue surface, followed by light activation to form a polymer coating on the surface.

Abstract: The present invention is directed to an automatic injection device containing a pre-loaded charge of medicament for automatically self-administering the medicament upon actuation thereof. The automatic injection device includes a dry compartment located within a housing for storing a predetermined dry charge of the medicament therein, a wet compartment within the housing for storing a predetermined amount of liquid injection solution therein, an activation assembly for causing the liquid injection solution in the wet compartment to be transferred to the dry wet compartment, and at least one compression assembly for maintaining the medicament located in the dry compartment under a continuous compressive state as the liquid injection solution passes through the dry compartment.

Abstract: A delivery system for delivering a shear-sensitive injectable material into the body of a mammal, such as a human being, acts as a mechanical feed that continuously mixes a shear-sensitive injectable material as it delivers the shear-sensitive injectable material to a target tissue, or to a site adjacent a target tissue. In one embodiment of the invention, the delivery system comprises an injector system including a rotatable mixing member coupled to a driving system. The injector system comprises a housing defining a lumen and having an output end and a driving system connection end and includes a rotatable mixing member for coupling to the driving system and for mixing and delivering the shear-sensitive injectable material. The driving system comprises a drive mechanism, an actuator capable of actuating the drive mechanism, and an interfacing member coupled to the drive mechanism for coupling with the mixing member to rotate the mixing member when the interfacing member is driven by the drive mechanism.

Abstract: A mixing/charging port for medical treatment capable of reliably absorbing air bubbles. The mixing/charging port for medical treatment includes a disc-like valve having an insertion hole at the center, a seating for supporting the lower part of the periphery of the valve with the center of the rear surface side of the valve not supported, and a cover for restraining the valve by covering at least the upper part of the periphery of the valve with the center on the front side surface of the valve left uncovered, wherein a fitting hole defined by an inner periphery of the cover works as an anchor for anchoring an insertion body to the mixing/charging port by fitting the insertion body to the fitting hole when the insertion body is inserted into the insertion hole; and the tip of the depressed part of the valve is brought into contact against the inner bottom surface of the seating when the valve is depressed by the insertion member.

Abstract: The drug solution container with a connector for communicating contains a drug solution container having at a tip end thereof an injection needle connecting part, and a hollow connector for communicating attached to a tip end of the drug solution container, and the connector for communicating contains a cylindrical guide part with a bottom capable of being slidably attached to an opening of a vial, and a hollow penetrating member provided at a center of the bottom of the guide part to penetrate the bottom. The penetrating member contains a penetrating needle at a tip end side with respect to the bottom, and a connecting part at a base end side with respect to the bottom, and the connecting part is connected to the injection needle connecting part through a fragile portion. According to the drug solution container with a connector for communicating, an operation for preparation of a drug solution can be easily carried out in a short period of time without causing injury of an operator or coring.

Abstract: An adapter for connecting a syringe system having a plurality of syringe barrels to an injector having a drive member. The adapter includes an injector attachment, an intermediate drive member including a plurality of plunger drives, and a syringe system attachment. Preferably, each of the plurality of plunger drives is in general alignment with one of the plurality of barrels when the syringe system is attached to the adapter via the syringe system attachment.

Abstract: An article of manufacture is provided comprising a vial having (a) a first chamber that is substantially filled with an injectable pharmaceutical formulation; (b) a second chamber that is substantially empty but for a gaseous medium; (c) a septum, impermeable to the gaseous medium, separating the first and second chambers; and (d) actuating means effective to bring the formulation and the gaseous medium into contact by breach of the septum such that the gaseous medium acts as an effective headspace for agitation of the formulation. The formulation comprises an aqueous medium, a drug in solid particulate form in a therapeutically effective amount suspended in the medium, and one or more wetting and/or suspending agents in an amount effective to provide controlled flocculation of the drug, at least one ingredient of the formulation being susceptible to oxidative degradation.

Abstract: The present invention relates to a drug delivery device for mixing and delivering a drug by injection. The device includes a housing having a first port or opening therein that receives a first container that contains a fluid or powdered drug, for example a lyophilized drug. The housing can also include a second port or opening that receives a second container that contains a fluid to be mixed with the drug to form an injectable fluid. The device includes a manifold having a channel that fluidly connects the first and second containers. A penetrating membrane such as a needle is used to inject the drug into a patient which is in fluid communication with the first container. The needle is movable from a storage position in the housing to an injection position extending through the housing.

Abstract: A solution, in particular for hemodialysis or peritoneal dialysis that permits attaining a desired glucose concentration without affecting the concentrations of other components in the solution. The solution consists of at least three individual solutions that are combined and administered after heat sterilization. The first solution contains calcium ions, electrolyte salts and optionally glucose in a concentration of 0-1000 mM and is acidified to a pH of less than 4.0 with a physiologically tolerable acid. The second solution contains glucose in a concentration different from that of the first solution and the remaining components of the first solution in the same concentration. The third solution contains a buffer in the physiological range. Also provided is a method of preparing a solution according to the invention, where the desired mixing ratio of the separate solutions is automatically established by a dialysis machine or peritoneal dialysis cycler.

Abstract: An applicator gun for spraying a medically useful multiple component fluid to an area of interest. The handheld applicator gun functionally receives a commercially available or standardized multi-syringe applicator, and dispenses fluid from the multi-syringe applicator in a controllable manner. The handheld applicator gun further includes a return stop and a dispensing stop to limit the force exerted on the multi-syringe applicator.

Abstract: A needleless injector cartridge has an adaptor for introducing fluid from a filling device into an orifice of the cartridge. The adaptor has a frangible connection which is broken to allow removal of the filling device after the cartridge is filled with the fluid.

Abstract: The present invention relates to a drug delivery device for mixing and delivering a drug by injection. The device includes a housing having a first port or opening therein that receives a first container that contains a fluid or powdered drug, for example a lyophilized drug. The housing can also include a second port or opening that receives a second container that contains a fluid to be mixed with the drug to form an injectable fluid. The device includes a manifold having a channel that fluidly connects the first and second containers. A penetrating membrane such as a needle is used to inject the drug into a patient which is in fluid communication with the first container. The needle is movable from a storage position in the housing to an injection position extending through the housing.

Abstract: This invention relates to kits for the preparation of a composition, which comprises a carrier phase that forms an implant or particles in the body, on the body or under physiological conditions. The carrier phase comprises at least one solid carrier material and a solvent, wherein the carrier material and the solvent are stored separately in the kit. The kit can also include an additional liquid phase to aid in forming the particles. An active compound included in the carrier phase is generally released in an extended manner. This invention also relates to compositions prepared from this kit and to methods for the preparation of the kits and the composition.

Abstract: Coaxial catheter delivery devices, methods to form coaxial microcatheters, and methods to deliver two part compositions, especially useful for formation of coaxial microcatheters for use in delivery of two part compositions to the neurovascular system.

Abstract: Methods and apparatus of forming in situ tissue adherent barriers are provided using a sprayer capable of applying two or more viscous crosslinkable components to tissue. The sprayer comprises separate spray nozzles for each of two or more crosslinkable solutions, with each nozzle surrounded by an annular gas flow outlet. Crosslinkable solutions are stored in separate compartments and communicated under pressure to the spray nozzles. In the presence of gas flow through the annular gas flow outlets, the crosslinkable solutions are atomized and mixed in the gas flow to form a spray. Multi-component hydrogel systems suitable for use with the inventive methods and apparatus are also described.

Abstract: A double syringe delivery system is disclosed for holding a pair of syringes in a manner so as to accommodate the simultaneous activation of the plunger of each syringe in order to effect simultaneous delivery of the contents of each syringe. The delivery system includes a delivery mechanism for delivering the contents of both syringes to a site of application. The delivery system further includes a support member that is positioned between the two syringe bodies. The elongated support member has resilient, C-shaped clamps on one end of the support member. The clamps are designed to be removably clamped onto the applicator so that the syringe barrels will be held together in a parallel manner. The elongated support member further comprises finger grips. A plunger connects the two syringe plungers so that they can also be simultaneously activated.

Abstract: A sealant applicator suitable for dispensing a coagulable sealant, for example a two-component fibrin sealant mixed in the applicator, employs impulse clearing to remove residual coagulated or coagulating material from the dispensing pathway and mixing chamber, if present. Impulses may be generated by manual application of a clearing member such as a plunger which can enter into the dispensing pathway to engage, dislodge and discharge residuals or can generate a gas impulse to impact the residuals to similar effect. A clearing valve having a clearing port can be operated by movement of the clearing member to provide access to the dispensing pathway.

Abstract: Devices and methods are provided for delivering fluid components of an embolic mass into a body cavity. A connector, which includes a receiving element, a first port, and a second port, is provided for securing an outer tubular element and an inner tubular element such that the outer tubular element coaxially surrounds the inner tubular element. The first port is in fluid communication with the lumen of the outer tubular element when the outer tubular element is secured to the receiving element; and the second port is in fluid communication with the lumen of the inner tubular element when the inner tubular element is secured to the connector. First and second fluid components of an embolic composition are delivered into the first and second ports of the connector and through the lumens of the outer and inner tubular elements for occlusion of the body cavity.

Abstract: A dispenser in which a dry powder (one component of a two-part adhesive tissue sealant and/or adhesive) is stored in a container (e.g., a carpule) having a septum at one end, an open end opposite the septum, and a movable plug. The powder is retained at the septum end of the container by the movable plug, which is displaced and pushed back as the solvent used for reconstituting the powder is introduced (e.g., through the septum). The second part of the tissue sealant is contained within a second container, also with a movable plug. After the first part is reconstituted, a manifold is fitted which pierces both septums and allows the contents to be dispensed. A dual syringe body supports the containers, and has pistons that enter the open ends to advance the movable plugs. Other embodiments of tissue adhesive and/or sealant dispensers and kits as well as methods of preparing tissue sealants are also described.

Abstract: An injection syringe generally comprised of a multichambered cylindrical ampule, a tripartite case of a front case; a middle case; a rear case, and a needle-holder, and a plunger: the multichambered cylindrical ampule including two chambers of a front space and a rear space, the front space being sealed forwardly with a packing penetrable by a needle and sealed rearwardly with a movable front gasket, and the rear space being sealed forwardly with the front gasket and sealed rearwardly with a movable rear gasket, and the ampule also including a bypass route longitudinally arranged on inner surface of the ampule such that the front gasket is located to take a position rearwardly apart from the bypass route before dissolution of a solid medicine, wherein the front space for admission of the solid medicine is separated from the rear space for admission of a medicinal solvent or dispersing agent; the middle case also including a short thread or fixer means provided externally at midportion thereof, and the rear ca

Abstract: A device for reconstituting liquid for medical use by bringing together a first liquid medium contained in a first vessel in the form of a cartridge (3) and a second medium, such as a drug in solid form, contained in a second vessel in the form of a vial (7), the device (19) comprising means (41) for supporting the first and second vessels, and a movable operating member (50) for applying a force to cause the first liquid medium to be delivered at a controlled rate from the first vessel into the second vessel. The first and second vessels may be provided in a pack (70) having liquid transfer means in the form of a needle (10).

Abstract: A system is provided for providing syringes filled with pharmaceuticals whose components must be stored separately, using a liquid such as water in a pharmaceutical vial, an active ingredient in a protosyringe such as a bottomless vial or a cartridge, and a combiner assembly which enables the content of the pharmaceutical vial to be transferred into the protosyringe and converts it into a ready-to-use syringe on activation. The combined assembly includes a tubular body having recesses at opposite ends for receiving capped ends of the vial and the protosyringe, and a hub and needle assembly between penetrable sheaths or shields which acts on activation of the assembly to enable the transfer and conversion referred to above. Components of the system may also be used to convert protosyringes and pharmaceutical vials containing pharmaceuticals into delivery systems.

Abstract: A system for dispensing a medium includes at least a first container to hold the medium, a pressurizing device, such as a pump, in fluid connection with the container for pressurizing the medium, and an agitation mechanism or device to maintain the components of the medium in a mixed state. The container and the pressurizing device can be separate units, as in the case of an bag or bottle in fluid connection with a peristaltic or other type of pump. The container and the pump can also be combined in a single unit, as in the case of a syringe, wherein the syringe barrel of the syringe acts to contain the medium and the syringe plunger pressurizes the medium within the syringe barrel. A method of injecting a multi-component medium includes the step of agitating the medium (for example, as described above) before or during an injection procedure to maintain the components of the medium in a mixed state.

Abstract: The present invention relates generally to medical devices for mixing, preparing and administering therapeutic compositions, and more particularly to a system comprising two syringes and a locking ring wherein two compositions are mixed between the two syringes immediately prior to administration.

Abstract: A system for dispensing a medium includes at least a first container to hold the medium, a pressurizing device, such as a pump, in fluid connection with the container for pressurizing the medium, and an agitation mechanism or device to maintain the components of the medium in a mixed state. The container and the pressurizing device can be separate units, as in the case of an bag or bottle in fluid connection with a peristaltic or other type of pump. The container and the pump can also be combined in a single unit, as in the case of a syringe, wherein the syringe barrel of the syringe acts to contain the medium and the syringe plunger pressurizes the medium within the syringe barrel. A method of injecting a multi-component medium includes the step of agitating the medium (for example, as described above) before or during an injection procedure to maintain the components of the medium in a mixed state.

Abstract: A dispenser in which a dry powder (one component of a two-part adhesive tissue sealant and/or adhesive) is stored in a container (e.g., a carpule) having a septum at one end, an open end opposite the septum, and a movable plug. The powder is retained at the septum end of the container by the movable plug, which is displaced and pushed back as the solvent used for reconstituting the powder is introduced (e.g., through the septum). The second part of the tissue sealant is contained within a second container, also with a movable plug. After the first part is reconstituted, a manifold is fitted which pierces both septums and allows the contents to be dispensed. A dual syringe body supports the containers, and has pistons that enter the open ends to advance the movable plugs. Other embodiments of tissue adhesive and/or sealant dispensers and kits as well as methods of preparing tissue sealants are also described.

Abstract: A novel device and method for applying two or more liquid components, for example fibrin sealant-forming components, comprises sources of the components fliud communication with, but remote from, an applicator for delivering the components to a desired site. Preferably, the user of such a device and method can actuate the application of the components by providing a signal to a controller which dispenses components from their sources to, and out of, the applicator. Greater ease, accuracy and control are realized by the user since the sources of components and controller are remote from the applicator and therefore not manually held by the user.

Abstract: A system for injecting a multi-component fluid into a patient includes a syringe and at least one agitation element moveable within the syringe to agitate the fluid. The agitation element includes surface structures to create vortices/mixing in the vicinity of the agitation element. An agitation element can also include surface structures to reduce the area of contact between the agitation element and another surface (for example, the interior wall of the syringe). An agitation element may also include a coating that includes at least one component of the multi-component fluid to be released into the fluid. A system for injecting a multi-component fluid into a patient includes a syringe and at least two agitating elements moveable within the syringe to agitate the fluid. A first one of the agitating elements has a density greater than a density of the fluid, and a second on of the agitating elements has a density less than the density of the fluid.

Abstract: A device for the formation and delivery of a mixture, notably a surgical adhesive, consisting of a receptacle adapted for easy handling by the surgeon, and including the means of receiving two syringe barrels containing the constituents of the mixture, the means of simultaneously expelling the contents, the means of maintaining the contents of syringe containing the first constituent, at a predetermined temperature setting which is higher than body temperature, and a mixer simultaneously receiving the contents of the two syringes, and the mixer also being used for cooling.

Abstract: A pre-filled syringe having an elastic-sliding valve to produce a hermetic closure inside a pre-filled syringe which keeps the liquid content to be injected totally isolated, in order to prohibit the liquid from coming in contact with the needle or the external air.

Abstract: A method and a needleless injection system for administering a medication. In order to simplify as far as possible the handling necessary for loading the injector with medication and thereby eliminate risks caused by a complex handling the method and system according to the invention provide loading of medication into a needleless injector device by means of a syringe prefilled with a medication, this loading step preferably including connecting the syringe to the injector device by means of a suitable coupling member or adapter and operating the syringe for transferring medication prefilled therein into the injector device. After this transfer the syringe and/or the coupling member or adapter are detached from the injector device, which is then ready to be operated for ejecting the loaded dosage of said medication from the injector device and thereby pass the selected dosage through the skin of an injection receiver.

Abstract: A filling device and method, particularly for two-component sealants such as fibrin sealants, which enables two fluids to be separately and directly filled to the reservoirs of a dual syringe fluid applicator from two storage containers, which can be standardized, sealed, sterilized bottles. The device has a connector which engages with the fluid applicator, is keyed to orient the applicator's fluid reservoirs in a predetermined manner and holds the containers in side-by-side alignment with the applicator. Two fluid conduits whose downward ends may be pointed to pierce seals on the bottles, extend between the applicator and the bottles and can each have a transverse reach to accommodate the girth of the bottles. The bottles may be tilted by the device to enable the conduits to draw maximal fluid from a lowermost point of the bottle. Tilting can be effected by a downward movement of the device supporting the applicator which movement can introduce the fluid conduits into the bottles.

Abstract: The multi-lumen intravenous extension system and method for independently conveying medicinal fluids include an extension including an elongate cylindrical body having a main lumen extending axially therein and at least one satellite lumen extending parallel with the main lumen in the extension, a coupling/connector at a proximal end of the extension, a liquid supply system connected to the proximal end connector for delivering liquid to the main lumen, at least one syringe coupled to the proximal connector for supplying a drug medication, pharmaceutical agent, or other liquid to the satellite or secondary lumen, and a connector forming a mixing chamber coupled to a distal end of the extension. The connector is adapted for connection to an intravenous or intra-vascular catheter or needle leading to an intra-vascular access site. The fluidic connection between the mixing connector and the multi-lumens of the extension substantially prevents over-pressurization of the vascular access device.

Abstract: An applicator gun for spraying a medically useful multiple component fluid to an area of interest. The handheld applicator gun functionally receives a commercially available or standardized multi-syringe applicator, and dispenses fluid from the multi-syringe applicator in a controllable manner. The handheld applicator gun further includes a return stop and a dispensing stop to limit the force exerted on the multi-syringe applicator.

Abstract: The present invention describes, inter alia, oxygen delivery agents or blood substitutes comprising a fluorinated gas and a stabilizing material, uses for the oxygen delivery agents or blood substitutes, and apparatus for making and delivering the oxygen delivery agents or blood substitutes.

Abstract: A system for dispensing a medium includes at least a first container to hold the medium, a pressurizing device, such as a pump, in fluid connection with the container for pressurizing the medium, and an agitation mechanism or device to maintain the components of the medium in a mixed state. The container and the pressurizing device can be separate units, as in the case of an bag or bottle in fluid connection with a peristaltic or other type of pump. The container and the pump can also be combined in a single unit, as in the case of a syringe, wherein the syringe barrel of the syringe acts to contain the medium and the syringe plunger pressurizes the medium within the syringe barrel. A method of injecting a multi-component medium includes the step of agitating the medium (for example, as described above) before or during an injection procedure to maintain the components of the medium in a mixed state.

Abstract: A dispenser in which a dry powder (one component of a two-part adhesive tissue sealant and/or adhesive) is stored in a container (e.g., a carpule) having a septum at one end, an open end opposite the septum, and a movable plug. The powder is retained at the septum end of the container by the movable plug, which is displaced and pushed back as the solvent used for reconstituting the powder is introduced (e.g., through the septum). The second part of the tissue sealant is contained within a second container, also with a movable plug. After the first part is reconstituted, a manifold is fitted which pierces both septums and allows the contents to be dispensed. A dual syringe body supports the containers, and has pistons that enter the open ends to advance the movable plugs. Other embodiments of tissue adhesive and/or sealant dispensers and kits as well as methods of preparing tissue sealants are also described.

Abstract: A fiber tip fluid output device is provided for holding a fiber tip in an electromagnetic energy cutting apparatus and for directing water particles over a radiation delivery end of the fiber tip. The output device includes a generally cylindrical body having an outer surface, a proximal end, a distal end, and a lumen extending therebetween. The lumen is sized and shaped to accommodate a fiber tip therethrough so that the fiber tip extends through the lumen. The device further includes a plurality of apertures extending around the generally cylindrical body, with each of the apertures fluidly connecting the outer surface to the lumen. Fluid is mixed around the cylindrical body, before entering the lumen through the apertures for additional mixing. The mixed fluid is then output from the lumen onto the fiber tip, for subsequent interaction with electromagnetic energy in an interaction zone above a target surface.

Abstract: A microinjection system comprises a device for housing dried forms of medical reagents, such as vaccines, hormones, etc. in single doses. Within a single chamber, a dry reagent bed is provided adjacent a compression component that keeps the bed compacted. In operation, diluent flows through the chamber to carry the reagent out of the chamber in fluid form. In the illustrated embodiments, the fluid carrying reagent is directly delivered from the chamber via a needle. Integral or connectable diluent delivery devices are disclosed for providing an appropriate volume of diluent to the reagent chamber. Unstable formulations of drugs, for example, can be safely stored in dry form. When injection is needed, the drug can be delivered almost instantly in fluid form simply by releasing diluent through the chamber, where the reagent bed is dissolved or suspended while the remaining reagent is continually compacted.

Abstract: A kneading device adapted for preparing calcium phosphate-based cement and for applying the cement directly to a required site which comprises a cylinder 1 which includes a hollow cylindrical body portion 11 and a nozzle 12 formed at the distal end of the cylindrical body portion; a plug 2 having an axial through-hole 21 slidably disposed within the proximal end of the cylindrical body portion; a piston assembly 3 which includes a shaft 31 extending through the through-hole 21 of the plug 2 for axial and rotatable movement, a kneading element 32 at the distal end of the shaft 31 within the cylindrical body portion, and a handle 34 formed at the proximal end of the shaft 31 external of the cylindrical body portion; a cover member 4 attached to and forming a closure for the nozzle 12; and a stop member 5 for locating the plug 2 in position at the proximal end of the cylindrical body portion.

Abstract: The invention relates to an apparatus for combining under sterile conditions a liquid component held in a first container and a solid or liquid component held in a second container.

Abstract: A laparoscopic spray device for selectively applying a multiple component material dispensed from a multiple component material applicator to a surgical site in vivo is disclosed. The device comprises an interface member capable of engaging a multiple component applicator, a body having at least two lumens therein, and a detachable spray tip in fluid communication with the body. The detachable spray tip includes a mixing chamber having at least one flexible mixing member positioned therein which is capable of creating a turbulent flow within a mixing chamber. In addition, the at least one mixing member prevents a back flow of material from the mixing chamber to the at least two lumens. The present invention is particularly useful in remotely applying multiple component tissue adhesives to an internal incision.

Abstract: Method for the in situ formulation of a medicinal substance solution for parenteral administration, in which at least two metered part-streams are continuously combined with the aid of a mixer to an active ingredient-containing total volumetric flow, characterized in that the resulting medicinal substance solution is not in thermodynamic equilibrium, and in that the resulting total volumetric flow after mixing is 0.2 ml/h to 500 ml/h, preferably 5 ml/h to 500 ml/h, an apparatus for carrying out the method, and an active ingredient administration kit which contains the apparatus.

Abstract: The present invention describes, inter alia, oxygen delivery agents or blood substitutes comprising a fluorinated gas and a stabilizing material, uses for the oxygen delivery agents or blood substitutes, and apparatus for making and delivering the oxygen delivery agents or blood substitutes.

Abstract: Fibrin sealant applicator systems are provided for dispensing a first and a second protein solution to form a biological adhesive which overcome the disadvantages of the prior art. The first and second protein solutions are preferably fibrinogen and thrombin solutions which may intermix on an application site or within the applicator to form a fibrin sealant. The fibrin sealant applicator systems according to the present disclosure include two piston-type sub-assemblies coupled to two vials storing the fibrinogen and thrombin via a coupling unit. The piston-type sub-assemblies store sterilized water within reservoirs which are in fluid communication with the vials via the coupling unit. The water is forced into the vials to form the fibrinogen and thrombin solutions.

Abstract: The device for bidirectional transfer between a vial (14) and a carpule (12) comprises:

Abstract: A needleless access system adapted to be mounted on a vial comprising a generally elongated tubular housing having an interior dividing wall, flexible hooks projecting upwardly from the dividing wall which are diametrically opposed, a pair of confronting splines projecting upwardly from the interior dividing wall, a hub insert having a piercing tip normally supported in an armed position by hook elements, a series of outwardly projecting teeth which engage and are guided in the splines during axial displacement of the hub insert relative to the splined housing, and said hub insert having means for mounting a syringe assembly whereby the hub insert maybe activated axially guided by the splines so that the piercing tip engages the stopper in a vial aligned therewith.

Abstract: The present invention provides an improved dispenser suitable for quickly and easily setting up and dispensing multi-part tissue sealants or other multi-part compositions requiring separation of the components until just prior to application on the tissue surface. The invention may further include an applicator having a handle and a blade attached to a first end of the handle. The invention may also include a dispensing tip having a blade attached to the distal end of the dispensing tip.

Abstract: A multifunctional device administering medicinal substances, comprising a cannula (10), suitable for administering a medical product (15), and a container and separator of substances (20), capable of being applied to one of the ends (14) of said cannula (10). The cannula (10) comprises a cylinder or tube (11) for containing the medical product and a thrusting piston (12) which can move, through a shaft (13), inside the tube (11), whereas the container-separator of substances (20) comprises a capsule (21) made of deformable material and a separator element (22), shaped as a regulator, suitable for closing the concave part of the capsule (21), so as to avoid the mixing of a liquid, powdered or granulated solute, contained therein, with the solvent consisting of the medical product (15), before the application of the compound. The mixing of the solvent and the solute takes place by deforming the capsule (21) and removing the separator element (22).

Abstract: An apparatus for delivering aerosolized fibrin endoscopically to a wound is disclosed. The apparatus has a pair of syringes for holding fibrin precursors, a mixing chamber for mixing the fibrin precursors separately with pressurized gas to form individual aerosol solutions, and a delivery tube for delivery of the aerosol solutions to a remote surgical site for formation of an aerosolized fibrin seal.