Means For Intermixing Liquid With Solid Or Different Liquid Patents (Class 604/82)
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Publication number: 20030023203Abstract: The present invention relates to a drug delivery device for mixing and delivering a drug by injection. The device includes a housing having a first port or opening therein that receives a first container that contains a fluid or powdered drug, for example a lyophilized drug. The housing can also include a second port or opening that receives a second container that contains a fluid to be mixed with the drug to form an injectable fluid. The device includes a manifold having a channel that fluidly connects the first and second containers. A penetrating membrane such as a needle is used to inject the drug into a patient which is in fluid communication with the first container. The needle is movable from a storage position in the housing to an injection position extending through the housing.Type: ApplicationFiled: September 23, 2002Publication date: January 30, 2003Applicant: Elan Pharma International LimitedInventors: Gilad Lavi, Gil Ygal, Israil Tsals, Joseph Gross
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Publication number: 20030018298Abstract: A delivery system for delivering a shear-sensitive injectable material into the body of a mammal, such as a human being, acts as a mechanical feed that continuously mixes a shear-sensitive injectable material as it delivers the shear-sensitive injectable material to a target tissue, or to a site adjacent a target tissue. In one embodiment of the invention, the delivery system comprises an injector system including a rotatable mixing member coupled to a driving system. The injector system comprises a housing defining a lumen and having an output end and a driving system connection end and includes a rotatable mixing member for coupling to the driving system and for mixing and delivering the shear-sensitive injectable material. The driving system comprises a drive mechanism, an actuator capable of actuating the drive mechanism, and an interfacing member coupled to the drive mechanism for coupling with the mixing member to rotate the mixing member when the interfacing member is driven by the drive mechanism.Type: ApplicationFiled: January 19, 2000Publication date: January 23, 2003Inventor: Barry N. Gellman
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Patent number: 6508801Abstract: The present invention provides methods, compositions and apparati for rapid pediatric resuscitation and/or emergency management. A standardized formulation of each commonly used resuscitation medication is provided so that calculating dosage amounts is simplified. The formulations are standardized to a pre-determined dosage concentration and packaged in containers which may be coded to provide a simple means of separating and recognizing each medication. The standardized medications may be provided in a self-contained set-up along with commonly used medical equipment for use in resuscitation procedures.Type: GrantFiled: August 27, 1999Date of Patent: January 21, 2003Inventor: S. Lee Fineberg
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Patent number: 6502608Abstract: A bone cement delivery apparatus is provided. The delivery apparatus includes a delivery tube and a connector. The delivery tube has an inner wall providing an axial bore. The connector is provided at a proximal end of the delivery tube. The connector includes at least one receiving slot in the inner wall. The receiving slot includes a transverse portion comprising an override surface and a local recess which cooperate to removably mate the delivery tube and the connector with a bone cement dispensing apparatus.Type: GrantFiled: February 14, 2000Date of Patent: January 7, 2003Assignee: Telios Orthopedic Systems, Inc.Inventors: Ronnie Burchett, Randy Scot Wills
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Publication number: 20020198490Abstract: A dispenser in which a dry powder (one component of a two-part adhesive tissue sealant and/or adhesive) is stored in a container (e.g., a carpule) having a septum at one end, an open end opposite the septum, and a movable plug. The powder is retained at the septum end of the container by the movable plug, which is displaced and pushed back as the solvent used for reconstituting the powder is introduced (e.g., through the septum). The second part of the tissue sealant is contained within a second container, also with a movable plug. After the first part is reconstituted, a manifold is fitted which pierces both septums and allows the contents to be dispensed. A dual syringe body supports the containers, and has pistons that enter the open ends to advance the movable plugs. Other embodiments of tissue adhesive and/or sealant dispensers and kits as well as methods of preparing tissue sealants are also described.Type: ApplicationFiled: August 9, 2002Publication date: December 26, 2002Applicant: 3M Innovative Properties CompanyInventors: David F. Wirt, Larry H. Dodge, Jeffrey D. Smith
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Publication number: 20020198564Abstract: A gas powered spraying device that can be used for single or multi-part reactive medical polymer compositions is provided. A fluid or one or more reactive solutions are sprayed independently at a tissue surface, and the spraying of each solution of multi-component embodiments is controlled by a separate valve. Each solution is provided with a separate spray outlet, and each spray outlet is surrounded by an annular sheath of flowing gas. Gas flow is provided at two or more flow levels, including a high level flow for active spraying and a low level bypass flow to remove drips and prevent clogging, which can improve device reliability. Gas pressure can be used to drive fluid to its spray outlet, as well as to spray the fluid from the outlet to the tissue surface.Type: ApplicationFiled: December 21, 2001Publication date: December 26, 2002Inventors: Dean M. Pichon, David J. Nedder, John R. Sousa, J. Jeffrey Kablik, Albert H. Linder
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Patent number: 6488650Abstract: A filling device and method, particularly for two-component sealants such as fibrin sealants, which enables two fluids to be separately and directly filled to the reservoirs of a dual syringe fluid applicator from two storage containers, which can be standardized, sealed, sterilized bottles. The device has a connector which engages with the fluid applicator, is keyed to orient the applicator's fluid reservoirs in a predetermined manner and holds the containers in side-by-side alignment with the applicator. Two fluid conduits whose downward ends may be pointed to pierce seals on the bottles, extend between the applicator and the bottles and can each have a transverse reach to accommodate the girth of the bottles. The bottles may be tilted by the device to enable the conduits to draw maximal fluid from a lowermost point of the bottle. Tilting can be effected by a downward movement of the device supporting the applicator which movement can introduce the fluid conduits into the bottles.Type: GrantFiled: December 8, 1999Date of Patent: December 3, 2002Assignee: Baxter International, Inc.Inventors: Gordon Howard Epstein, Mitchell E. Levinson, Richard Spero, Adam Hagmann
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Patent number: 6478771Abstract: The present invention relates to a drug delivery device for mixing and delivering a drug by injection. The device includes a housing having a first port or opening therein that receives a first container that contains a fluid or powdered drug, for example a lyophilized drug. The housing can also include a second port or opening that receives a second container that contains a fluid to be mixed with the drug to form an injectable fluid. The device includes a manifold having a channel that fluidly connects the first and second containers. A penetrating membrane such as a needle is used to inject the drug into a patient which is in fluid communication with the first container. The needle is movable from a storage position in the housing to an injection position extending through the housing.Type: GrantFiled: November 12, 1999Date of Patent: November 12, 2002Assignee: Elan Pharma International LimitedInventors: Gilad Lavi, Gil Yigal, Izrail Tsals, Joseph Gross
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Publication number: 20020165483Abstract: A medical fluid delivery system for reactive fluids such as tissue adhesive fluids including fibrin glues whereby reactive fluids in separate syringes are expelled from the system while a separate compressed gas is released around, adjacent to, or proximate the expelled reactive fluids such that the fluids and gas mix and are propelled onto a site.Type: ApplicationFiled: November 13, 2001Publication date: November 7, 2002Inventors: Curtis Miller, Jon Hoogenakker, Alan Lonnemann
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Patent number: 6475183Abstract: A filling device for connecting a dispensing instrument having multiple fluid reservoirs to multiple containers is disclosed. More particularly, the present invention discloses a connecting device capable of coupling the individual reservoirs of a dispensing instrument to multiple fluid containers. The apparatus includes a body, a collar extending from the body, a plurality of tubes in fluid communication with a plurality of inlet ports formed in the body, and a hood adapted to simultaneously receive a plurality of containers therein. The containers are positioned within the hood to allow the plurality of tubes to simultaneously and separately draw fluid from the fluid containers and transferring the material into the individual reservoirs of the dispensing instrument.Type: GrantFiled: May 7, 1999Date of Patent: November 5, 2002Assignee: Baxter International Inc.Inventors: Gordon Howard Epstein, Mitchell E. Levinson, Richard Spero
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Patent number: 6475182Abstract: A fluidic media introduction apparatus for closing an opening in a vessel wall includes an elongated member with a fluidic media introduction port and a guide wire lumen. The guide wire lumen extends from a proximal portion to a distal portion of the elongated member. A fluidic media mixing chamber is positioned in the elongated member and coupled to a fluidic media introduction port. A fluidic media delivery lumen is coupled to the mixing chamber. A fluidic media advancement port is positioned at the distal portion of the elongated member. An inflatable member is coupled to the distal portion of the elongated member.Type: GrantFiled: August 26, 1998Date of Patent: November 5, 2002Inventors: Olexander Hnojewyj, Gregory M Cruise, Stuart D Edwards, Edward Gough
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Publication number: 20020151843Abstract: The present invention seeks to provide an improved needle design and needle assembly which is particularly adapted for live cell vaccines and the like. More specifically, the needle assembly includes a gap filler with an inner funnel which is specifically shaped and adapted to fill a turbulence gap naturally formed between a conventional needle retainer and syringe. By maintaining a laminar flow of the fluid, the turbulence and the destruction of live cells are reduced. Additionally, some of the needle designs include a funnel-shaped mouth which is utilized during the filling of the syringe to minimize physical damage to the cell wall or membrane of the live cells otherwise caused by the sharp edges at the tip of a standard injection needle. A breakaway needle assembly is also disclosed.Type: ApplicationFiled: April 17, 2001Publication date: October 17, 2002Inventors: Rafael S. Correa, William D. Samson, Marco A. Quiroz
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Patent number: 6464667Abstract: A bedside-pharmacy system for the preparation and delivery of intravenous drugs. The system includes a liquid inlet for connection to a liquid supply, vial receptacles, and a liquid outlet for providing the intravenous drug in mixed, liquid form to the patient. The system may include a chamber having a variable volume, and a valve mechanism, which may be actuated to control flow between the liquid outlet, the variable-volume chamber, the vial receptacles and the liquid inlet. The system induces change in the volume of the variable-volume chamber and actuates the valve mechanism, so as to introduce liquid from the liquid inlet into the vials and reconstitute or dilute the drugs and so as to deliver the drugs to the patient. In a preferred embodiment, the liquid inlet, the vial receptacles, the variable-volume chamber, the liquid outlet and the valve mechanism (in other words, all components that come into contact with the liquid) are located in a disposable cassette, which may be received in a control unit.Type: GrantFiled: July 22, 1999Date of Patent: October 15, 2002Assignee: Deka Products Limited PartnershipInventors: Dean L. Kamen, Charles M. Grinnell, Marc A. Mandro, Dennis Gilbreath, Kevin Grant, Jason A. Demers, William T. Larkins, Robert Manning, Richard Lanigan
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Patent number: 6464663Abstract: The applicator (10) for depositing a one- or multi-component fluid, particularly a tissue adhesive, comprises a housing (12) arranged for attachment of at least one supply container (16) for the fluid. The supply container (16) comprises a discharge opening (28) and a piston (20) for sliding displacement in the direction of said discharge opening (28). A tensioning lever (58) is pivotally supported on the housing (12), which, when manually operated, causes movement of a spring tensioning element (54) by which a spring (46) for storage of mechanical energy can be tensioned. Coupled to the spring tensioning element (54) is a drive element (66) being adapted to be driven, by the stored mechanical energy of said spring (46), in increments and which is arranged to move a press-on element (84) acting on said piston (20) for displacing it in the direction of said discharge opening (28) of said supply container (16).Type: GrantFiled: November 9, 1999Date of Patent: October 15, 2002Assignee: OMRIX Biopharmaceuticals SAInventor: Freddy Zinger
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Publication number: 20020147462Abstract: Achieving lung volume reduction includes occluding a lumen of a bronchial tube of a lung to prevent air flow to at least a region of the lung. Bronchial occluders such as polymerizable materials and mechanical devices, such as sutures, staples, clips, clamps, foam, balloons, umbrellas and ball bearings are provided for occluding a bronchial tube. Methods include mixing thickeners or foaming agents with polymerizable compositions and introducing the mixture into a lumen of a bronchial tube. Mechanisms for mixing components and delivering the mixture to a lumen of a bronchial tube are also provided.Type: ApplicationFiled: September 12, 2001Publication date: October 10, 2002Applicant: Closure Medical CorporationInventors: Eric A. Mair, Daniel L. Hedgpeth, Melanie A. Vander Klok, Jeffrey G. Clark, Anthony J. Sherbondy
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Patent number: 6461325Abstract: This invention provides a medical device for delivering volumetric quantities of a first and a second biochemically reactive fluid comprising a first container having an opening, the first container being adapted to contain the first biochemically reactive fluid; a second container having a second fluid opening adjacent the first fluid opening, the second container being adapted to contain the second biochemically reactive fluid; a spray unit for separately atomizing the first and second biochemically reactive fluids into an aerosol with at least one energy source of a liquid energy, a mechanical energy, a vibration energy, and an electric energy; a fluid pressurizer for pressurizing the first and the second biochemically reactive fluids for delivery under pressure through the spray unit onto a surface; and wherein the first and second biochemically reactive fluids first mix on the surface.Type: GrantFiled: August 31, 1999Date of Patent: October 8, 2002Assignee: Baxter International Inc.Inventors: Yves Delmotte, Arnold Bilstad, David Amrani, James DiOrio, Atif M. Yardimci, David W. Pennington, James S. Slepicka, Cristina Stadler
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Patent number: 6458095Abstract: A dispenser in which a dry powder (one component of a two-part adhesive tissue sealant and/or adhesive) is stored in a container (e.g., a carpule) having a septum at one end, an open end opposite the septum, and a movable plug. The powder is retained at the septum end of the container by the movable plug, which is displaced and pushed back as the solvent used for reconstituting the powder is introduced (e.g., through the septum). The second part of the tissue sealant is contained within a second container, also with a movable plug. After the first part is reconstituted, a manifold is fitted which pierces both septums and allows the contents to be dispensed. A dual syringe body supports the containers, and has pistons that enter the open ends to advance the movable plugs. Other embodiments of tissue adhesive and/or sealant dispensers and kits as well as methods of preparing tissue sealants are also described.Type: GrantFiled: March 10, 2000Date of Patent: October 1, 2002Assignee: 3M Innovative Properties CompanyInventors: David F. Wirt, Larry H. Dodge, Jeffrey D. Smith
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Publication number: 20020138039Abstract: An injector for liquid medicine comprises a cylindrical body 1, first and second gasket 2, 3 contained in a lumen of cylindrical body 1. The cylindrical body 1 is provided with a fluid inlet 13 and a fluid outlet 14 in opposite sides of the cylindrical body 1 with respect to the longitudinal axis thereof. Second gasket 3 is spaced from the first gasket 2 to form a fluid chamber 4 between them. The first gasket 2 is adapted to be moved by sliding along the inner wall of the cylindrical body 1 from a first position to the distal end 11 of cylindrical body 1 via a second position. The fluid inlet 13 is opened at a position closer to the distal end 11 of the cylindrical body 1 than the outlet 14 is. The first gasket 2 is stopped at a second position where the fluid chamber 4 is communicated with the fluid outlet 14 but prevented from fluid-communication with the fluid inlet 13.Type: ApplicationFiled: March 15, 2002Publication date: September 26, 2002Inventor: Mitsuru Hasegawa
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Publication number: 20020138038Abstract: A device for dispensing at least two mutually reactive components, such as fibrinogen and thrombin, comprising a supplier (12A, 12B) having a primary channel for supplying a respective one of said at least two reactive components to a dispenser (14) having secondary channels (18A, 18B) for separately discharging said components at a distal end orifice thereof opening into a target area for external intimate mixing of the respective reactive components outside a distal tip end of said dispenser (14). A distributor (38, 40) is interposed between said supplier and said dispenser for multiplying the number of the respective primary channels with at least a factor 2. Adjacent ones of said secondary channels (18A, 18B) are adjoined to primary channels (32, 34) intended for supply of reactive components of different kind.Type: ApplicationFiled: January 14, 2002Publication date: September 26, 2002Inventor: Olle Ljungquist
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Patent number: 6454739Abstract: An improved delivery device for applying two-component adhesives such as fibrin sealant is disclosed. The improved delivery device includes a pair of syringe bodies for storing a first and a second adhesive components, respectively, a pair of plungers associated with the pair of syringe bodies for expelling the first and the second component from the pair of syringe bodies, and a pair of needles. The needles are connected to the syringe bodies for providing separate passages for the components, and have distal end surfaces which are apart from each other with a predetermined distance, and faced each other with an angle in the range of 10° to less than 180°.Type: GrantFiled: September 5, 2000Date of Patent: September 24, 2002Assignee: Korea Greencross Corp.Inventor: Chong E. Chang
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Publication number: 20020128683Abstract: A process and apparatus for one-step preparation of fibrinogen adhesive by polyethylene glycol-mediated precipitation from plasma are disclosed. The methods and apparatus of the invention permit preparation of autologous fibrinogen adhesive composition from the patient during surgery, and can be applied generally to provide such compositions. Also disclosed are an apparatus and method for application of sealant comprising this fibrinogen adhesive composition.Type: ApplicationFiled: February 5, 2002Publication date: September 12, 2002Inventor: Gordon H. Epstein
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Publication number: 20020123719Abstract: The present invention related to a drug delivery device for mixing and delivering a drug by injection. The devices includes a housing having a first port or opening therein that receives a first container that contains a fluid or powdered drug, for example, a lyophilized drug. The housing can also include a second port or opening that receives a second container that contains a fluid to be mixed with the drug to form an injectable fluid. The device includes a manifold having a channel that fluidly connects the first and second containers. A penetrating membrane such as a needle is used to inject the drug into a patient which is in fluid communication with the first container. The needle is movable from a storage position in the housing to an injection position extending through the housing.Type: ApplicationFiled: February 7, 2002Publication date: September 5, 2002Applicant: ELAN PHARMA INTERNATIONAL LIMITEDInventors: Gilad Lavi, Gil Ygal, Izrail Tsals, Joseph Gross
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Publication number: 20020120231Abstract: An infusion system, comprising a housing; and a connecting hub which is attachable to the housing, the connecting hub having an internal Y-shaped flow channel structure which comprises a first flow channel exiting the distal end of the connecting hub; a second flow channel exiting the proximal end of the connecting hub; and a third flow channel exiting the proximal end of the connecting hub, the first, second and third flow channels all intersecting within the connecting hub.Type: ApplicationFiled: February 13, 2002Publication date: August 29, 2002Inventors: Joel S. Douglas, Robert L. Hugo, Cynthia Zhang
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Patent number: 6440101Abstract: A syringe system requires a decreased vertical travel for sealing during a lyophilization process and therefore provides for increased utilization of space in a lyophilization chamber. The syringe system is provided with a sterility maintenance sleeve including a stopper affixed thereto for sealingly engaging the syringe barrel to define a drug chamber. The sterility maintenance sleeve is provided with a venting passage to permit egress of vapor from the drug chamber during lyophilization. A plug cap cooperating with the sterility maintenance sleeve includes an occluding tip which is adapted to occupy the venting passage and seal the drug chamber after lyophilization. The plug cap is provided with a support structure in the form of flexible fins for supporting the plug cap in a venting position in which the occluding tip is removed from the venting passage to permit egress of drug solution vapor from the drug chamber during lyophilization.Type: GrantFiled: May 31, 2000Date of Patent: August 27, 2002Assignee: Abbott LaboratoriesInventors: Richard W. Grabenkort, Randall M. Farmer
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Publication number: 20020101785Abstract: An apparatus and method for mixing a liquid component and a powdered component to form a bone filler has first and second syringes each having a barrel, a plunger and an exit port. The plunger is moveable with the barrel of each syringe along a longitudinal axis of the barrel. An end portion of each plunger extends beyond the end of each barrel when the plunger tip is spaced from the exit port and can be activated to move the plunger tip toward the exit port. A mechanism for mixing the liquid and powdered components is operatively connected to each of the barrels and plunger of the first and second syringes so that the relative sliding movement of first and second parts of the mechanism simultaneously moves the plungers and barrels of the first and second syringes relative to one another to move the combined liquid and powdered components back and forth between the first and second syringe.Type: ApplicationFiled: January 26, 2001Publication date: August 1, 2002Applicant: Howmedica Osteonics Corp.Inventors: Brian Edwards, Paul Higham, Joseph Zitelli
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Patent number: 6425880Abstract: A syringe (1) contains a liquid medical substance which has to be mixed with another substance before use. This is done by interconnecting the syringe (1) and a capsule containing the other substance by a transfer device (2) which screws into a socket (4) in the piston-seal (3) of the syringe (1) and penetrates through into the liquid. The device (2) extends slidably but non-rotatably through a screw cap (8) which fits to the rear end of a housing (13) for the syringe (1). As the cap (8) screws on, so does the transfer device (2) screw into the piston-seal (3). The relationship between the screw threads is such that, on removing the screw cap (8), the transfer device (2) disengages from the piston-seal (3) first, so that the latter cannot be inadvertently removed from the syringe.Type: GrantFiled: March 14, 2001Date of Patent: July 30, 2002Assignee: Owen Mumford LimitedInventor: Jeremy Marshall
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Publication number: 20020087118Abstract: A pharmaceutical delivery system for reconstituting and delivering a two-part pharmaceutical composition through a catheter, consisting of a first container, typically a syringe, for containing a first component of a pharmaceutical, with a first broachable closure closing the container, and a fluid displacement apparatus configured to move fluid into and out of the container through the broachable closure; a second container containing a second component of the pharmaceutical, with a second broachable closure closing the container; a body comprising first, second and third open-ended vessels extending from the diverter valve operative to alternatively connect the first and second vessels or the first and third vessels; the first vessel communicating with a socket for receiving at least a part of the first container, including the broachable closure of the first container, the socket containing a first closure broaching member such as a cannula; the second vessel communicating with a socket for receiving at leType: ApplicationFiled: December 29, 2000Publication date: July 4, 2002Applicant: Duoject Medical Systems Inc.Inventors: David L, Reynolds, Daniel H. MacDonald
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Patent number: 6413784Abstract: Multi-sectioned fluid delivery devices with sensor membranes for use in detection of target molecules in gas or liquid samples are provided.Type: GrantFiled: March 15, 2000Date of Patent: July 2, 2002Assignee: Idego ApSInventors: Jorgen Schjerning Lundsgaard, David Morgan Thomas, Torsten Bjoern
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Publication number: 20020077589Abstract: A method of producing injectable foam, comprises: providing a first syringe containing a gas and a second syringe containing a liquid comprising a foaming substance and passing the gas and the liquid back and forth between the first syringe and the second syringe by operation of the first syringe and the second syringe so that the gas and the liquid mix turbulently to form the foam.Type: ApplicationFiled: January 22, 2001Publication date: June 20, 2002Inventor: Lorenzo Tessari
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Publication number: 20020077588Abstract: A power assisted method and injector device for controllably delivering to patients a dispersion medicament or diagnostically active agent, the homogeneity of which is preserved throughout delivery. Diagnostically active agents disclosed are gas microbubble suspensions useful in ultrasonic diagnostic imaging and liposomal formulations in which liposome vesicles are loaded with iodinated compounds.Type: ApplicationFiled: December 3, 1998Publication date: June 20, 2002Inventors: MICHEL SCHNEIDER, LAURENT JAKOB, CHRISTOPHE GOLAY, JEAN BROCHOT, FENG YAN
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Patent number: 6406455Abstract: Injection devices, such as needleless injection devices, and methods of making and using the same are disclosed.Type: GrantFiled: December 17, 1999Date of Patent: June 18, 2002Assignee: BioValve Technologies, Inc.Inventors: John Willis, Thaddeus Minior, Robert Gonnelli
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Publication number: 20020072703Abstract: A coupling system can utilize a first receptacle and a second receptacle to couple syringes together. Syringes can be used to mix viscous material and/or dispense the viscous material. Furthermore, a kit can be provided that contains parts used in mixing and/or dispensing viscous material.Type: ApplicationFiled: July 18, 2001Publication date: June 13, 2002Inventors: Peter Nollert, Lance Stewart, Hidong Kim
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Patent number: 6403771Abstract: The present invention relates to the field of site directed therapy. More specifically the invention relates to site directed radio therapy, and provides a method for production of radioconjugates and an apparatus for radioimmunotherapy. The method, conjugates and apparatus can be practicalized without the need for radioactive shielding and/or airtight facilities. Without these restrictions the invention provides a simple and efficient means of therapy at the bed-side of the patient.Type: GrantFiled: January 28, 1998Date of Patent: June 11, 2002Assignee: Actinium Pharmaceuticals, LimitedInventor: Maurits W. Geerlings
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Publication number: 20020068896Abstract: A device for reconstituting liquid for medical use by bringing together a first liquid medium contained in a first vessel in the form of a cartridge (3) and a second medium, such as a drug in solid form, contained in a second vessel in the form of a vial (7), the device (19) comprising means (41) for supporting the first and second vessels, and a movable operating member (50) for applying a force to cause the first liquid medium to be delivered at a controlled rate from the first vessel into the second vessel. The first and second vessels may be provided in a pack (70) having liquid transfer means in the form of a needle (10).Type: ApplicationFiled: December 10, 2001Publication date: June 6, 2002Applicant: Applied Research Systems ARS Holding N.V.Inventors: Grenville Arthur Robinson, Michael Anthony Hobbs, Martyn Omar Rowlands, John Richard Calvert
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Patent number: 6398761Abstract: The syringe system has a two separate pathways for delivering two materials for mixing. The syringe system has a plunger unit with two plungers that engage two barrels of a dual barrel cartridge to push the two materials into two separate lumens in a nipple on the dual barrel cartridge. The nipple has side portals for directing the materials away from each other as the materials are pushed out of the side portals. The nipple is inserted into a delivery chamber of a delivery tip that houses a static mixing element. The sidewalls of the delivery chamber mate with surfaces of the nipple such that the materials continue to have separate pathways after being pushed out of the side portals and reach the static mixing element.Type: GrantFiled: January 19, 2001Date of Patent: June 4, 2002Assignee: Ultradent Products, Inc.Inventors: Dan J. Bills, Dan E. Fischer, Bruce S. McLean
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Patent number: 6394975Abstract: A process and apparatus for one-step preparation of fibrinogen adhesive by polyethylene glycol-mediated precipitation from plasma are disclosed. The methods and apparatus of the invention permit preparation of autologous fibrinogen adhesive composition from the patient during surgery, and can be applied generally to provide such compositions. Also disclosed are an apparatus and method for application of sealant comprising this fibrinogen adhesive composition.Type: GrantFiled: May 28, 1997Date of Patent: May 28, 2002Assignee: Baxter International Inc.Inventor: Gordon H. Epstein
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Patent number: 6391001Abstract: An intravenous line flushing device for preventing clotting of blood by the addition of saline solution to an intravenous line. The intravenous line flushing device includes a sleeve having an inner panel and an outer panel. Each of the panels has a top edge and a bottom edge. The top edge of the inner panel is integrally coupled to the top edge of the outer panel, and the bottom edge of the inner panel is integrally coupled to the bottom edge of the outer panel such that a space is defined between the inner and outer panels. The inner and outer panels are substantially air impermeable. A generally sealed container is positioned in the space between the inner and outer panels. A first agent is disposed in the space. A second agent is disposed in the container. Breaking the container mixes the first and second agents such that a gas is produced, which inflates the sleeve. A primary tube has a first end and a second end. The first end is adapted to removably fluidly engage a pouch.Type: GrantFiled: September 21, 2000Date of Patent: May 21, 2002Inventors: Jolie Graham, Joyce R. Varhola
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Publication number: 20020058909Abstract: A mixing device comprising a body portion, a removable tip portion, wherein said tip portion comprises an opening and a filter portion, wherein said filter portion comprises four filters. The mixing device may also comprise a plunger portion adapted for insertion into said body portion, wherein said plunger portion comprises a first plunger, wherein said first plunger comprises a mixing element, wherein said mixing element comprises a series of blades and said blades being disposed of within said body portion, and a second plunger, wherein said second plunger comprises a compression disk, and wherein a portion of a first plunger is disposed of within a second plunger, and wherein said first plunger operates independent of said second plunger.Type: ApplicationFiled: December 28, 2001Publication date: May 16, 2002Inventors: Richard J. Deslauriers, Robert T. Potash, Stephanie Bonin
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Patent number: 6387074Abstract: A drug delivery device for delivery of a drug which comprises a mixture of a first substance and a second substance, the device including a first chamber (24) for housing the first substance, a second chamber (30) for housing the second substance and a membrane (28) which on application of a predetermined condition thereto is movable from a first disposition in which it partitions the first and second chambers to prevent mixture of the first and second substances to a second disposition in which it enables the first and second substances to be mixed. In one aspect, the membrane (28) contains a barrier material comprising polychlorotrifluoroethylene or a copolymer thereof, polyvinylidene chloride or a copolymer thereof or a silicon oxide. In another aspect, the first chamber (24) is formed from a polyethylene based polymer.Type: GrantFiled: February 18, 1998Date of Patent: May 14, 2002Assignee: Astra AktiebolagInventors: Petri Horppu, Jƶrgen Friis
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Publication number: 20020055708Abstract: The present invention relates generally to medical devices for mixing, preparing and administering therapeutic compositions, and more particularly to a system comprising two syringes and a locking ring wherein two compositions are mixed between the two syringes immediately prior to administration.Type: ApplicationFiled: September 24, 1999Publication date: May 9, 2002Inventor: KENNETH R. PETERSON
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Patent number: 6379328Abstract: The present invention is related with an improved syringe having a novel piston design. The syringe comprises an outer tube or cylinder made of, for example, plastic material, narrowed at its outlet for fitting a detachable hollow needle. Inside the outer tube the novel piston is slidable fitted including at its forward end a coupling defined by a coupling bolt and a retaining head which form part of the piston body. To the coupling a rubber bulb is rotatably fitted including a longitudinal hole for allowing fluids flow from tube to the needle and from the piston to the tube. The forward end of the piston includes an orifice defining fluid communication between the inner volume of the hollow piston and the inner volume of the tube. During the operation the piston can be rotated so as to align the hole of said rubber bulb and said orifice of the piston forward end for defining a fluid channel from the syringe to the hollow needle.Type: GrantFiled: July 9, 1999Date of Patent: April 30, 2002Inventor: Fernando Horacio Mac Clay
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Publication number: 20020049405Abstract: A device and method for the mixing a two-part composition, where such composition may be characterized as synthetic bone being formed by the mixing of a liquid solution and a powder. The device is comprised of a syringe within a syringe, where the contents of the first syringe pass directly from the outlet of the first syringe into the second syringe. A filtering mechanism is further incorporated into the outlet of the second syringe such that the filtering mechanism restricts the removal of the powder, but allows the passage of solution. The filtering mechanism serves an innovative function that permits the application of solution to ensure saturation and then permits the removal of excess solution so as to minimize too rapid or excessive drying times of the synthetic bone. This invention further discloses a method of utilizing vacuum pressure to remove air bubbles that may be present in the synthetic bone that affects the ability of the solution and powder to form a cohesive bond.Type: ApplicationFiled: June 11, 2001Publication date: April 25, 2002Inventors: Richard J. Deslauriers, Robert T. Potash
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Publication number: 20020042591Abstract: System for the release of equal proportions of two flowable substances having two syringes, of which at least one is also used alone or in combination with other syringes, especially for dental purposes. In order to enable the connected syringes to be used irrespective of the current piston position, detachable devices (14, 22) for coupling the syringe bodies (1, 11) and devices (30) for coupling the syringe pistons, irrespective of their current position, are provided.Type: ApplicationFiled: September 25, 2001Publication date: April 11, 2002Inventors: Wolfgang Muhlbauer, Hans Horth, Frauke Robel
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Patent number: 6367962Abstract: A kneading device adapted for preparing calcium phosphate-based cement and for applying the cement directly to a required site which comprises a cylinder 1 which includes a hollow cylindrical body portion 11 and a nozzle 12 formed at the distal end of the cylindrical body portion; a plug 2 having an axial through-hole 21 slidably disposed within the proximal end of the cylindrical body portion; a piston assembly 3 which includes a shaft 31 extending through the through-hole 21 of the plug 2 for axial and rotatable movement, a kneading element 32 at the distal end of the shaft 31 within the cylindrical body portion, and a handle 34 formed at the proximal end of the shaft 31 external of the cylindrical body portion; a cover member 4 attached to and forming a closure for the nozzle 12; and a stop member 5 for locating the plug 2 in position at the proximal end of the cylindrical body portion.Type: GrantFiled: June 20, 2000Date of Patent: April 9, 2002Assignee: NGK Spark Plug Co., Ltd.Inventors: Yoichiro Mizutani, Takenori Sawamura, Masateru Hattori, Masahiko Okuyama
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Publication number: 20020035349Abstract: A drug delivery system for administering preset doses of a substance such as a drug, vaccine or the like is provided. The drug delivery system includes a holder and a pre-filled drug container such as a syringe which is securely retained in the holder. The drug container includes a barrel for containing the substance, a movable stopper situated within the barrel, and a blunt end having an opening through which the substance within the barrel can be expelled. The holder includes a distal portion and a proximal portion, each configured to accommodate the drug container, with the distal portion being able to be assembled to the proximal portion, which acts as a plunger rod during activation of the delivery system.Type: ApplicationFiled: November 5, 2001Publication date: March 21, 2002Inventors: Hubert Jansen, Lionel Vedrine
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Patent number: 6355024Abstract: A system to provide a specified volume of a medical fluid from a bulk source to a dose and/or delivery container for injection into a patient. The fluid path between the bulk container and the delivery container is physically separated at a connecting site before fluid is injected from the delivery container into the patient. The bulk container may be a bag or bottle, and the delivery container may be a syringe or bag. A bag delivery container may be contained in a pressurizeable chamber and fluid may be delivered by providing pressure to a membrane in the chamber contacting a wall of the bag. The system may be automated.Type: GrantFiled: July 14, 1999Date of Patent: March 12, 2002Assignee: Mallinckrodt Inc.Inventors: James R. Small, Frank M. Fago, Gary S. Wagner, Mitchell A. Smith, Joseph B. Tyson
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Publication number: 20020004643Abstract: A spike for facilitating the introduction of liquid under pressure into a container containing a substance is provided which includes an elongate spike shaft having a spike side wall, a longitudinal axis, a distal end and a proximally located end portion, where the distal end has a sharp, pointed tip. An introduction channel is located within the spike shaft for receiving liquid into the container where a portion of the introduction channel is angled to cause liquid to travel out of the introduction channel in a direction non-parallel to the longitudinal axis of the spike shaft. An extraction channel may be included within the spike shaft for removing liquid from the container, where the extraction channel extends through the elongate spike shaft towards the proximally located end portion.Type: ApplicationFiled: May 23, 2001Publication date: January 10, 2002Inventors: Ehoud Carmel, Gilad Lavi, Gil Yigal, Izrail Tsals
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Publication number: 20010056256Abstract: A device and method for providing a suspended agent such as a contrast agent without mechanical resuspension. A volume of agent (12) is divided into sub-volumes in a network (8) of tubes (18), cells (42), sponges (44), grooves (48), etc. A propellant fluid (16) flows through the network (8) to release the suspended agent (12). The network (8) may be internal to a container (10) for the propellant fluid (16). Alternatively, the network (8) may be adjacent an exit port (24) of a container (10) for the propellant fluid (16), or may be in-line between a propellant fluid container (10) and a patient. The invention reduces sedimentation of agents into one or a few aggregates and eliminates a mechanical mixing step. The invention thus provides a uniformly suspended agent, improving patient health and safety and increasing cost and time savings.Type: ApplicationFiled: July 30, 2001Publication date: December 27, 2001Applicant: MALLINCKRODT INC.Inventors: Michael Scott Hughes, William Hagen, Brian Doty, Gordon Persaud
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Publication number: 20010056272Abstract: A solution kit includes a prefilled syringe and a container containing a solvent charged therein. The prefilled syringe comprises a barrel provided at a distal end thereof with a tip closed by a twist-off type closing member, while the solvent container having a mouth portion closed by a twist-off type closing member. The tip of the prefilled syringe and the mouth portion of the solvent container are configured to engage with one another in liquid-tight engagement.Type: ApplicationFiled: June 22, 2001Publication date: December 27, 2001Inventors: Hideki Yagi, Yoshihisa Hama, Masafumi Aramata, Kensuke Natsui
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Patent number: 6331172Abstract: A medical fluid applicator for dispensing a fluid onto biological tissues in tissue adhesive or sealant applications includes a dispensing pathway with an audible loudness indicator that signals the cumulative amount of fluid delivered by varying the pitch or tone of audible signals emitted at discrete volumetric increments. A suction pathway is also included for applying vacuum pressure to the applicator tip contemporaneous with the fluid application. The medical fluid applicator further includes a clearing pathway for retrogradedly withdrawing coagulated mixed fluids, such as mixed two-part tissue adhesives, from the applicator tip. A valve manifold and a shuttle valve are actuated to adjust the operation of vacuum pressure in the device between the various suctioning, clearing, and venting conduits of the device. The valve manifold is also adapted to couple a vent pathway and the suction pathway simultaneously to the vacuum conduit adapted for connection to a vacuum source.Type: GrantFiled: April 14, 1997Date of Patent: December 18, 2001Assignee: Baxter International Inc.Inventors: Gordon Howard Epstein, Alan Plyley, Russell James Redmond