Method Of Introducing A Polynucleotide Molecule Into Or Rearrangement Of Genetic Material Within A Plant Or Plant Part Patents (Class 800/278)
  • Patent number: 11371052
    Abstract: Methods and compositions are described for producing a phytase in transgenic maize plants and then incorporating parts of the transgenic maize plants in animal feed. The feed phytase enzyme displays activity across a broad pH range, and tolerance to temperatures that are often encountered during the process of preparing animal feeds. Methods of producing an animal feed that incorporate the transgenic maize plants, parts thereof or plant derived phytases, as well as methods of promoting the release of inorganic phosphate from a phytic acid in an animal, producing an animal meat, or reducing the ratio of intake of an animal feed per weight of the animal meat by feeding an animal with the animal feed incorporating transgenic maize plants are provided.
    Type: Grant
    Filed: November 3, 2017
    Date of Patent: June 28, 2022
    Assignee: AGRIVIDA, INC.
    Inventors: R. Michael Raab, Oleg Bougri, Philip A. Lessard, Christopher Bonin, Michael B. Lanahan
  • Patent number: 11369072
    Abstract: According to the invention, there is provided seed and plants of the corn variety designated CV457958. The invention thus relates to the plants, seeds and tissue cultures of the variety CV457958, and to methods for producing a corn plant produced by crossing a corn plant of variety CV457958 with itself or with another corn plant, such as a plant of another variety. The invention further relates to corn seeds and plants produced by crossing plants of variety CV457958 with plants of another variety, such as another inbred line. The invention further relates to the inbred and hybrid genetic complements of plants of variety CV457958.
    Type: Grant
    Filed: September 21, 2020
    Date of Patent: June 28, 2022
    Assignee: MONSANTO TECHNOLOGY, LLC
    Inventor: Daniel J. Lubich
  • Patent number: 11365424
    Abstract: Isolated polynucleotides and polypeptides, and recombinant DNA constructs are useful for conferring improved drought tolerance. Compositions (such as plants or seeds) comprising these recombinant DNA constructs; and methods utilizing these recombinant DNA constructs. The recombinant DNA constructs comprise a polynucleotide operably linked to a promoter that is functional in a plant, wherein said polynucleotides encode drought tolerance polypeptides.
    Type: Grant
    Filed: November 1, 2018
    Date of Patent: June 21, 2022
    Inventors: Guangwu Chen, Yang Gao, Guihua Lu, Guanfan Mao, Changgui Wang, Guokui Wang
  • Patent number: 11339400
    Abstract: The inventive technology relates to systems and methods for enhanced in vivo production, accumulation and modification of cannabinoids. In one embodiment, the invention may include systems and methods for enhanced in vivo biosynthesis of chemically-modified water-soluble cannabinoids in a whole plant, or a cell suspension culture system.
    Type: Grant
    Filed: January 8, 2019
    Date of Patent: May 24, 2022
    Assignee: Trait Biosciences, Inc.
    Inventors: Richard T. Sayre, Elton Carvalho Gonçalves, Tawanda Zidenga
  • Patent number: 11324178
    Abstract: Plants with resistance to glyphosate are disclosed herein. In one embodiment, the disclosure relate to human induced non-transgenic mutations in the EPSPS gene in plants.
    Type: Grant
    Filed: September 15, 2020
    Date of Patent: May 10, 2022
    Assignee: ARCADIA BIOSCIENCES, INC.
    Inventors: Charles Paul Moehs, Michael N. Steine, Jessica C. Mullenberg, Ann J. Slade
  • Patent number: 11319553
    Abstract: The present invention relates to polynucleotides and polypeptides associated with increased resistance of plants towards pathogenic fungi of the genus Mycosphaerella, and fungi related thereto, particularly towards fungi inducing Sigatoka disease complex and fungi inducing other diseases in banana and additional Musa plant spices; to use thereof for controlling plant disease associated with the fungal pathogens; and to the production of genetically engineered plants having increased resistance to the pathogenic fungi.
    Type: Grant
    Filed: November 27, 2018
    Date of Patent: May 3, 2022
    Assignees: RAHAN MERISTEM (1998) LTD., EVOGENE LTD.
    Inventors: Dror Shalitin, Sharon Ayal, Ada Viterbo Fainzilber, Hagai Karchi, Eli Khayat, Tanya Gontmakher
  • Patent number: 11304395
    Abstract: Compositions and methods for reducing the level of nornicotine and N?-nitrosonornicotine (NNN) in tobacco plants and plant parts thereof are provided. The compositions comprise isolated polynucleotides and polypeptides for a root-specific nicotine demethylases, CYP82E10, and variants thereof, that are involved in the metabolic conversion of nicotine to nornicotine in these plants. Compositions of the invention also include tobacco plants, or plant parts thereof, comprising a mutation in a gene encoding a CYP82E10 nicotine demethylase, wherein the mutation results in reduced expression or function of the CYP82E10 nicotine demethylase. Seed of these tobacco plants, or progeny thereof, and tobacco products prepared from the tobacco plants of the invention, or from plant parts or progeny thereof, are also provided. Methods for reducing the level of nornicotine, or reducing the rate of conversion of nicotine to nornicotine, in a tobacco plant, or plant part thereof are also provided.
    Type: Grant
    Filed: May 7, 2020
    Date of Patent: April 19, 2022
    Assignee: North Carolina State University
    Inventors: Ralph E. Dewey, Ramsey S. Lewis
  • Patent number: 11299523
    Abstract: The invention provides methods for improving plant yield, biomass accumulation and stress tolerance. A novel AP2-like transcription factor MPG1, which when modulated impacts grain yield, biomass and abiotic and biotic stress tolerance when compared to non-modulated plants. The invention further provides methods using recombinant expression cassettes, host cells, transgenic plants and breeding methods using the same.
    Type: Grant
    Filed: July 6, 2017
    Date of Patent: April 12, 2022
    Assignee: Colorado State University Research Foundation
    Inventors: Daniel R. Bush, Amanda K. Broz, Bettina E. Broeckling, Michael M. Friedman
  • Patent number: 11299744
    Abstract: The present disclosure relates to transgenic plants that over-express PP2CABA and methods of using such for enhancing osmotic stress tolerance.
    Type: Grant
    Filed: December 12, 2017
    Date of Patent: April 12, 2022
    Assignee: Academia Sinica
    Inventors: Su-May Yu, Chun-Hsien Lu, Tuan-Hua David Ho, Shuen-Fang Lo
  • Patent number: 11299746
    Abstract: The present invention relates to Phytophthora capsici resistant Capsicum annuum plants wherein said resistance is conferred by a combination of two genes. The present invention further relates to the use of these genes for providing Phytophthora capsici resistant Capsicum annuum plants and proteins encoded by the present genes.
    Type: Grant
    Filed: July 6, 2020
    Date of Patent: April 12, 2022
    Assignee: Enza Zaden Beheer B.V.
    Inventors: Christianus Cornelis Nicolaas Van Schie, Karin Ingeborg Posthuma, Tieme Zeilmaker, Geert Johannes De Boer
  • Patent number: 11297861
    Abstract: Newly identified fungal sweet-taste modifying proteins, and the cDNA encoding said proteins are described. Specifically, Myd proteins active in sweet taste activation, and the cDNA encoding the same, are described, along with methods for isolating such cDNA and for isolating and expressing such proteins. Also disclosed is use of a sweetening composition which includes the proteins of the invention, and methods to provide improved flavor to a product for oral administration.
    Type: Grant
    Filed: June 25, 2021
    Date of Patent: April 12, 2022
    Assignee: MycoTechnology, Inc.
    Inventors: Marina Nadal, Anthony J. Clark, Zheyuan Guo, Stephen A. Gravina, Anthony Westgate, Bassam Alkotaini, Ashley Han, Brendan Sharkey, Evan Strassburger, Joseph Meilen, Hyung Chang
  • Patent number: 11293033
    Abstract: Provided herein are compositions and methods of integrating one or more exogenous donor nucleic acids into one or more exogenous landing pads engineered into a host cell's genome. In certain embodiments, the exogenous landing pads and exogenous donor nucleic acids comprise standardized, compatible homology regions so that exogenous donor nucleic acids can integrate into any of the landing pads, independent of the genomic sequences surrounding the landing pads. In certain embodiments, the methods comprise contacting the host cell comprising landing pads with one or more exogenous donor nucleic acids, and a nuclease capable of causing a double-strand break within the landing pads, and recovering a host cell comprising one or more exogenous donor nucleic acids integrated in any of the landing pads.
    Type: Grant
    Filed: May 18, 2017
    Date of Patent: April 5, 2022
    Assignee: AMYRIS, INC.
    Inventors: Kevin George, Andrew Main, Chia-Hong Tsai
  • Patent number: 11293031
    Abstract: Compositions and methods for reducing the level of nornicotine and N?-nitrosonornicotine (NNN) in Nicotiana plants and plant parts thereof are provided. The compositions comprise isolated polynucleotides and polypeptides for cytochrome P450s that are involved in the metabolic conversion of nicotine to nornicotine in these plants. Expression cassettes, vectors, plants, and plant parts thereof comprising inhibitory sequences that target expression or function of the disclosed cytochrome P450 polypeptides are also provided. Methods for the use of these novel sequences to inhibit expression or function of cytochrome P450 polypeptides involved in this metabolic conversion are also provided. The methods find use in the production of tobacco products that have reduced levels of nornicotine and its carcinogenic metabolite, NNN, and thus reduced carcinogenic potential for individuals consuming these tobacco products or exposed to secondary smoke derived from these products.
    Type: Grant
    Filed: April 28, 2020
    Date of Patent: April 5, 2022
    Assignees: North Carolina State University, University of Kentucky Research Foundation
    Inventors: Ralph E. Dewey, Balazs Siminszky, Steven W. Bowen, Lily Gavilano
  • Patent number: 11286504
    Abstract: The present invention discloses A METHOD TO PRODUCE PROTEIN IN PENICILLIUM AMAGASAKIENSE'S SLEEPING SPORES BY TRANSFORMATION OF SSRNA. The method includes three steps of culture of Penicillium amagasakiense and collection of spores, pretreatment of Penicillium anagasakiense spores, and electroporation of Penicillium anagasakiense spores by using HDEN method. In the present invention, non-germinated spores are used as a starting material for introduction of exogenous molecules. The exogenous protein coding single stranded RNA is introduced into the resting spores of Penicillium amagasakiense by employing the HDEN electrotransformation technique to express protein. The method of this invention is simple and fast, the effect is excellent, and the transformation rate reaches more than 90%.
    Type: Grant
    Filed: March 8, 2019
    Date of Patent: March 29, 2022
    Assignee: FUZHOU UNIVERSITY
    Inventor: Jun Lin
  • Patent number: 11279944
    Abstract: A method for conferring tolerance to a 4-hydroxyphenylpyruvate dioxygenase (HPPD) inhibitor herbicide in a plant includes reducing expression of at least one HPPD enzyme in the plant.
    Type: Grant
    Filed: October 18, 2018
    Date of Patent: March 22, 2022
    Assignee: BASF AGRICULTURAL SOLUTIONS SEED US LLC
    Inventors: Manuel Dubald, Marc Linka
  • Patent number: 11273234
    Abstract: The present invention relates to a self-assembling polypeptide, such as a spider silk polypeptide, for use as a coating material to form a uniform coating around an implant for the purpose of reducing or preventing capsular fibrosis associated with the use of such an implant in the human body.
    Type: Grant
    Filed: October 11, 2019
    Date of Patent: March 15, 2022
    Assignee: Amsilk GmbH
    Inventors: Axel Leimer, Lin Romer, Nathalie Maksimovikj
  • Patent number: 11267850
    Abstract: The present invention relates to nucleic acids encoding amino acid sequences for the biosynthesis of janthitrem in janthitrem producing endophytes. The present invention also relates to constructs and vectors including such nucleic acids, and related polypeptides, regulatory elements and methods.
    Type: Grant
    Filed: August 11, 2017
    Date of Patent: March 8, 2022
    Assignee: Agriculture Victoria Services PTY LTD
    Inventors: German Carlos Spangenberg, Kathryn Michaela Guthridge, Ross Mann, Timothy Ivor Sawbridge, Sophie Elizabeth Davidson, Simone Vassiliadis, Inoka Kumari Hettiarachchige, Simone Jane Rochfort, Emma Jane Isobel Ludlow, Natasha Denise Brohier
  • Patent number: 11248234
    Abstract: The present invention refers to method for producing a transgenic plant with increased herbicide tolerance or resistance as compared to a corresponding non-transformed wild type plant, comprising transforming a plant cell or a plant cell nucleus or a plant tissue with a nucleic acid molecule encoding a mutated HPPD polypeptide, as well as to the nucleic acid, and plants with increased HPPD-inhibiting herbicide tolerance or resistance comprising the nucleic acid of the invention.
    Type: Grant
    Filed: February 10, 2016
    Date of Patent: February 15, 2022
    Assignee: BASF SE
    Inventors: Stefan Tresch, Maciej Pasternak, Liliana Parra Rapado, Jill M. Paulik, Jens Lerchl, Gilbert Besong, Markus Kordes, Thomas Mietzner, Eva Stauffer
  • Patent number: 11242535
    Abstract: The invention relates to gene expression regulatory sequences, specifically introns that act as enhancers of gene expression, the promoter and terminator sequences endogenously associated with these introns. Presence of these intronic enhancer sequences in proximity to promoter sequences leads to enhancement of gene expression. Methods of finding such new intronic enhancer sequences and using them to generate transgenic plants are also described.
    Type: Grant
    Filed: June 3, 2019
    Date of Patent: February 8, 2022
    Inventors: Scott Diehn, Ajit Nott, David A Selinger, Carl Simmons, Priyanka Bhyri, Venkata S Tavva
  • Patent number: 11236347
    Abstract: Methods and compositions for Ochrobactrum-mediated transformation of plants are provided. Methods include but are not limited to using an Ochrobactrum strain to transfer a polynucleotide of interest to a plant cell. These include VirD2-dependent methods. Compositions include an Ochrobactrum strain, transfer DNAs, constructs and/or plasmids. These include Ochrobactrum strains having a plasmid comprising one or more virulence gene(s), border region, and/or origin of replication. Plant cells, tissues, plants, and seeds comprising a polynucleotide of interest produced by the methods are also provided.
    Type: Grant
    Filed: August 26, 2016
    Date of Patent: February 1, 2022
    Inventors: Ajith Anand, Steven Henry Bass, Sean M. Bertain, Hyeon-Je Cho, Anthony J. Kinney, Theodore M. Klein, Michael Lassner, Kevin E. McBride, York Moy, Barbara Ann Marie Rosen, Jun-Zhi Wei
  • Patent number: 11236399
    Abstract: The invention provides a transgenic Glycine max event MON87751, plants, plant cells, seeds, plant parts, progeny plants, and commodity products comprising event MON87751. The invention also provides polynucleotides specific for event MON87751, plants, plant cells, seeds, plant parts, and commodity products comprising polynucleotides for event MON87751. The invention also provides methods related to event MON87751.
    Type: Grant
    Filed: January 16, 2020
    Date of Patent: February 1, 2022
    Assignee: Monsanto Technology LLC
    Inventors: Kim A. Beazley, Wen C. Burns, Robert H. Cole, II, Ted C. MacRae, John A. Miklos, Lisa G. Ruschke, Kairong Tian, Liping Wei, Kunsheng Wu
  • Patent number: 11230717
    Abstract: The present invention refers to a method for controlling undesired vegetation at a plant cultivation site, the method comprising the steps of providing, at said site, a plant that comprises at least one nucleic acid comprising a nucleotide sequence encoding a wild-type hydroxyphenyl pyruvate dioxygenase or a mutated hydroxyphenyl pyruvate dioxygenase (mut-HPPD) which is resistant or tolerant to a HPPD-inhibiting herbicide and/or a nucleotide sequence encoding a wild-type homogentisate solanesyl transferase or a mutated homogentisate solanesyl transferase (mut-HST) which is resistant or tolerant to a HPPD-inhibiting herbicide, applying to said site an effective amount of said herbicide. The invention further refers to plants comprising mut-HPPD, and methods of obtaining such plants.
    Type: Grant
    Filed: April 28, 2014
    Date of Patent: January 25, 2022
    Assignee: BASF SE
    Inventors: Maciej Pasternak, Stefan Tresch, Helmut Kraus, Johannes Hutzler, Jens Lerchl, Thomas Mietzner, Jill Marie Paulik
  • Patent number: 11225669
    Abstract: The invention provides recombinant DNA molecules comprising novel synthetic Intergenic Sequence Regions for use in plants to reduce the interaction of a first transgene expression cassette on a second transgene cassette when inserted between the first transgene cassette and second transgene cassette. The invention also provides transgenic plants, plant cells, plant parts, and seeds comprising the novel synthetic Intergenic Sequence Regions. The invention also provides methods to reduce the interaction between transgene expression cassettes using the novel synthetic Intergenic Sequence Regions.
    Type: Grant
    Filed: July 6, 2020
    Date of Patent: January 18, 2022
    Assignee: Monsanto Technology LLC
    Inventor: Ian W. Davis
  • Patent number: 11220694
    Abstract: The invention relates to novel plants, seeds and compositions, as well as improvements to plant breeding and methods for creating modifications in plant genomes.
    Type: Grant
    Filed: January 29, 2019
    Date of Patent: January 11, 2022
    Assignee: Inari Agriculture, Inc.
    Inventors: Tomá{hacek over (s)} {hacek over (C)}ermák, Richard Bailey Flavell, Eva Konecna, Yajie Niu, Michael Lee Nuccio, Jennifer A. Raji, Randall William Shultz, Davide Sosso, Maria Margarita D. Unson, Barry Andrew Martin, John Patrick Casey, Jr., Michael Andreas Kock
  • Patent number: 11180772
    Abstract: The present invention relates to a method of increasing resistance against fungal pathogens of the order Pucciniales, preferably the family Phacopsoraceae, in plants and/or plant cells. This is achieved by increasing the expression of an RLK2 protein or fragment thereof in a plant, plant part and/or plant cell in comparison to wild type plants, wild type plant parts and/or wild type plant cells. Furthermore, the invention relates to transgenic plants, plant parts, and/or plant cells having an increased resistance against fungal pathogens, in particular, pathogens of the order Pucciniales, preferably the family Phacopsoraceae, and to recombinant expression vectors comprising a sequence that is identical or homologous to a sequence encoding an RLK2 protein.
    Type: Grant
    Filed: July 30, 2018
    Date of Patent: November 23, 2021
    Assignee: BASF PLANT SCIENCE COMPANY GMBH
    Inventors: Holger Schultheiss, Tobias Mentzel, Ralf Flachmann
  • Patent number: 11178832
    Abstract: The present invention relates to crop breeding. More particularly, the present invention relates to targeted modification of root angle to enhance abiotic stress tolerance in maize. In one aspect, the invention provides recombinant maize exhibiting increased root angle by decreasing the function of the maize ZMCIPK15 gene. Methods of making the recombinant maize and various methods of plant selection and breeding are further provided.
    Type: Grant
    Filed: November 9, 2018
    Date of Patent: November 23, 2021
    Assignees: WISCONSIN ALUMNI RESEARCH FOUNDATION, THE PENN STATE RESEARCH FOUNDATION
    Inventors: Shawn Michael Kaeppler, Hannah Marie Schneider, Jonathan Paul Lynch, Malcolm John Bennett
  • Patent number: 11174467
    Abstract: Transgenic plants having enhanced yield and having enhanced seed yield are disclosed. The transgenic plants are transformed with a transgenic polynucleotide encoding one or more metabolic enzymes. The metabolic enzymes can be from any biological source. The transgenic polynucleotide(s) comprises a nucleic acid sequences encoding the metabolic enzymes under the control of functional plant promoters, the one or more metabolic enzymes are targeted to the plastids by the addition of plastid targeting signals. Optionally the functional plant promoters are seed specific promoters and the metabolic enzymes are targeted to the plastids by the addition of plastid targeting peptide heterologous to the metabolic enzymes. Methods of making the transgenic plants and transgenic polynucleotides are disclosed. The magnitude of the increases in seed yield achieved with these transgenic plants are simply unprecedented.
    Type: Grant
    Filed: April 8, 2016
    Date of Patent: November 16, 2021
    Assignee: YIELD10 BIOSCIENCE, INC.
    Inventors: Meghna Malik, Jihong Tang, Kristi D. Snell
  • Patent number: 11174491
    Abstract: Methods and materials for modulating low light and/or shade tolerance, and red light specific responses in plants are disclosed. For example, nucleic acids encoding low light and/or SD+EODFR-tolerance polypeptides are disclosed as well as methods for using such nucleic acids to transform plant cells. Also disclosed are plants having increased low light and/or SD+EODFR tolerance. In addition, methods and materials involved in increasing UV-B tolerance in plants and methods and materials involved in modulating biomass levels in plants are provided.
    Type: Grant
    Filed: July 25, 2018
    Date of Patent: November 16, 2021
    Assignee: Ceres, Inc.
    Inventors: Shing Kwok, Kenneth Bounds, Ryan Miller, Sam Harris, James Burns, Roger I. Pennell, Vijay Sharma, Michael F. Portereiko, Han-Suk Kim, Gerard Magpantay
  • Patent number: 11168036
    Abstract: The invention relates to compositions for retaining soil moisture and improving plant growth in dry soils, which, together with one or more moisture retaining materials and wetting agents, comprises iron(III) oxides and optionally potassium metabisulfite [borken (HU), E224] as potentiating agent. The iron(III) oxides preferably are microparticulate. The composition Suitably comprises iron(III)oxides and potassium metabisulfite as potentiating agent. Other aspects of the invention relate to binding the moisture content of soils, as well as compositions for use in enhancing the efficacy of Soil retaining compositions.
    Type: Grant
    Filed: November 21, 2018
    Date of Patent: November 9, 2021
    Assignee: INVENTION CENTER KFT.
    Inventors: Antal Vattay, Rikárd Vattay, Katalin Andrea Posta, Péter Póti, Imre Varga, Gyula Záray, Miklós Lóczi, Gábor Miklós Szurop
  • Patent number: 11168334
    Abstract: Isolated polynucleotides and polypeptides, and recombinant DNA constructs, suppression DNA constructs and CRISPR/Cas9 DNA constructs are provided. Compositions (such as plants or seeds) with modified expression or activity of the isolated polypeptides are obtained by transforming the regenerable plant cell with a suppression DNA construct or CRISPR/Cas construct. The plants with improving drought tolerance are obtained by decreasing the expression or activity of the isolated polynucleotide.
    Type: Grant
    Filed: October 18, 2017
    Date of Patent: November 9, 2021
    Inventors: Guangwu Chen, Chengfeng Du, Yang Gao, Zantang Li, Guihua Lu, Guanfan Mao, Changgui Wang, Guokui Wang
  • Patent number: 11168332
    Abstract: The invention provides recombinant host organisms (e.g., plants) genetically modified with a polyunsaturated fatty acid (PUFA) synthase system and one or more accessory proteins (e.g., PPTase and/or ACoAS) that allow for and/or improve the production of PUFAs in the host organism. The present invention also relates to methods of making and using such organisms (e.g., to obtain PUFAs) as well as products obtained from such organisms (e.g., oil and/or seed).
    Type: Grant
    Filed: June 2, 2020
    Date of Patent: November 9, 2021
    Inventors: Terence A. Walsh, Daniel Gachotte, Ann Owens Merlo, Paul Gordon Roessler, James Metz, Scott Bevan, Jerry Kuner
  • Patent number: 11149294
    Abstract: Described herein are biological devices and methods for using the same to produce carbo sugars. The biological devices include microbial cells transformed with a DNA construct containing genes for producing a cellulose synthase and galactomannan galactosyltransferase. In some instances, the biological devices also include a gene for lipase. Methods for altering the viscosity of petroleum oil using the carbo sugars are also described herein. Finally, methods for degreasing or decontaminating water mixed with petroleum oil or other fatty substances or a surface coated with petroleum oil or other fatty substances using the carbo sugars are described herein.
    Type: Grant
    Filed: April 30, 2019
    Date of Patent: October 19, 2021
    Assignee: BIOCAPITAL HOLDINGS, LLC
    Inventors: Raul Cuero Rengifo, Juliana Londoño Murillo, Mariana Sanchez Londoño, Daniel Agudelo Valencia, Juan Miguel Sanchez Bustamante, Mario Antonio Franco Jimenez, Lina Clemencia Sanchez Bustamante
  • Patent number: 11142765
    Abstract: The present disclosure relates to RNA interference (RNAi) reagents, such as short hairpin microRNA (shmiR) and short hairpin RNA (shRNA), for treatment of oculopharyngeal muscular dystrophy (OPMD), compositions comprising same, and use thereof to treat individuals suffering from OPMD or which are predisposed thereto. The present disclosure also relates to the use of the RNAi reagents in combination with PABPN1 replacement reagents, such as constructs which encode functional PABPN1 protein, for treatment of OPMD, compositions comprising same, and use thereof to treat individuals suffering from OPMD or which are predisposed thereto.
    Type: Grant
    Filed: December 14, 2017
    Date of Patent: October 12, 2021
    Assignee: Benitec IP Holdings, Inc.
    Inventors: Vanessa Strings-Ufombah, David Suhy
  • Patent number: 11136588
    Abstract: The present invention relates to method for preparing a plant from a protoplast comprising knocking-out or knocking-in one or more the endogenous gene of the protoplast, and the plant regenerated from a genome-modified protoplast prepared by the above method.
    Type: Grant
    Filed: October 6, 2016
    Date of Patent: October 5, 2021
    Assignees: INSTITUTE FOR BASIC SCIENCE, SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION, AICT
    Inventors: Jin Soo Kim, Jungeun Kim, Sunghwa Choe, Je Wook Woo, Soon Il Kwon
  • Patent number: 11136591
    Abstract: The invention generally relates to plant cells and plants modified to increase resistance to necrotrophs or drought and methods of selecting and using the same. More specifically, the invention relates in part to plant cells and/or plants modified to eliminate or reduce as compared to control plants cell the NADPH oxidase activity or expression of certain respiratory burst oxidase homolog (RBOH) proteins and methods of selecting for and using the same.
    Type: Grant
    Filed: July 31, 2018
    Date of Patent: October 5, 2021
    Assignee: WISCONSIN ALUMNI RESEARCH FOUNDATION
    Inventors: Ashish Ranjan, Mehdi Kabbage, Damon Smith
  • Patent number: 11136559
    Abstract: The invention generally relates to engineered prephenate dehydrogenases and arogenate dehydrogenases and methods of using the same. More specifically, the invention relates in part to compositions including engineered prephenate dehydrogenases (PDH) polypeptides and engineered arogenate dehydrogenase (ADH) polypeptides with altered substrate preferences and tyrosine sensitivities and methods of using the same.
    Type: Grant
    Filed: January 29, 2018
    Date of Patent: October 5, 2021
    Assignee: WISCONSIN ALUMNI RESEARCH FOUNDATION
    Inventors: Hiroshi A. Maeda, Craig Albert Schenck
  • Patent number: 11130961
    Abstract: The invention provides a transgenic soybean event MON 87708 plant and plants, plant cells, seeds, plant parts, and commodity products derived from event MON 87708. The invention also provides polynucleotides specific for event MON 87708 and plants, plant cells, seeds, plant parts, and commodity products comprising polynucleotides specific for event MON 87708. The invention also provides methods related to event MON 87708.
    Type: Grant
    Filed: April 5, 2019
    Date of Patent: September 28, 2021
    Assignee: Monsanto Technology LLC
    Inventors: Ronald J. Brinker, Wen C. Burns, Paul C. C. Feng, Anju Gupta, Sio-Wai Hoi, Marianne Malven, Kunsheng Wu
  • Patent number: 11130957
    Abstract: Provided are isolated polynucleotides and nucleic acid constructs which comprise a nucleic acid sequence at least 80% identical to a nucleic acid sequence selected form the group consisting of SEQ ID NOs: 277, 1-276, 278-469 and 785-2397; and isolated polypeptides which comprise an amino acid sequence at least 80% homologous to an amino acid sequence selected from the group consisting of SEQ ID NOs: 482, 470-481, 483-784 and 2398-3818. Also provided are transgenic cells and plants expressing same and methods of using same for increasing nitrogen use efficiency, yield, biomass, growth rate, vigor, oil content, fiber yield, fiber quality, and/or abiotic stress tolerance of a plant.
    Type: Grant
    Filed: August 27, 2019
    Date of Patent: September 28, 2021
    Assignee: Evogene Ltd.
    Inventors: David Panik, Basia Judith Vinocur, Hagai Karchi
  • Patent number: 11130956
    Abstract: The present invention relates to the fields of genetically modified Agrobacterium strains, vaccine adjuvants, and generally molecular biology and immunology. Provided herein are modified Agrobacterium strains that produce lipopolysaccharide (LPS) having reduced toxicity or detoxified lipopolysaccharide, and methods of obtaining such strains for plant-based production of biologies. Also provided herein are uses of reduced or detoxified LPS as adjuvants suitable for clinical use.
    Type: Grant
    Filed: May 31, 2018
    Date of Patent: September 28, 2021
    Assignee: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY
    Inventors: Qiang Chen, Ming Yang, Huafang Lai
  • Patent number: 11124801
    Abstract: The compositions and methods disclosed relate to DNA compositions, plant cells, seeds, plant parts that relate to maize plants with increased grain yield trait. Also provided are assays for detecting the presence of the maize DP-202216-6 event based on the DNA sequence of the recombinant construct inserted into the maize genome and the DNA sequences flanking the insertion site. Kits and conditions useful in conducting the assays are provided.
    Type: Grant
    Filed: April 17, 2019
    Date of Patent: September 21, 2021
    Inventors: Nathan David Coles, Olga Danilevskaya, Jeffrey Habben, Mary A Rupe, Jeffrey R Schussler, Bo Shen, Benjamin P Weers, Jingrui Wu
  • Patent number: 11124797
    Abstract: The present invention provides a novel gene WMS conferring wheat male sterility, its anther-specific expression promoter, and uses of the same. In wheat, a well-known gene Ms2 causing dominant male sterility has been widely applied in recurrent selection in China. A RNA-seq approach was performed to reveal the anther-specific transcriptome in a pair of Ms2 isogenic lines, ‘Lumai 15’ and ‘Lumai 15+Ms2’. As a result, a WMS gene was identified showing anther-specific expression at the early stage of meiosis and only in wheat carrying the Ms2 gene. The regulation of WMS could alter plant male fertility. The promoter of WMS was found to comprise anther-specific activity. Thus, the present invention might be used to achieve anther-specific gene expression, to develop male sterility in various plant species, to establish recurrent selection in various plant species, and to assist hybrid seed production.
    Type: Grant
    Filed: April 11, 2016
    Date of Patent: September 21, 2021
    Assignee: SHANDONG AGRICULTURAL UNIVERSITY
    Inventors: Daolin Fu, Mincheng Luo, Juan Qi, Fei Ni, Bo Lv, Shuyun Wang
  • Patent number: 11111499
    Abstract: Provided are isolated polynucleotides encoding a polypeptide at least 80% homologous to the amino acid sequence selected from the group consisting of SEQ ID NOs: 757, 456-756, 758-774, 8385-10836, and 10838-14462; and isolated polynucleotide comprising nucleic acid sequences at least 80% identical to SEQ ID NO: 377, 1-376, 378-455, and 775-8384. Also provided are nucleic acid constructs comprising same, isolated polypeptides encoded thereby, transgenic cells and transgenic plants comprising same and methods of using same for increasing yield, biomass, growth rate, vigor, oil content, fiber yield, fiber quality, abiotic stress tolerance, and/or nitrogen use efficiency of a plant.
    Type: Grant
    Filed: December 28, 2018
    Date of Patent: September 7, 2021
    Assignee: Evogene Ltd.
    Inventors: Noa Matarasso, Eyal Emmanuel, David Panik, Inbal Nurith Dangoor, Hagai Karchi
  • Patent number: 11112409
    Abstract: The present disclosure relates generally to detection of contamination of a sample or diagnosis of subject based upon detection or quantification of amino acid sequences in a sample, specifically to the identification and use of molecular biomarkers for Candida albicans biofilm infections.
    Type: Grant
    Filed: February 10, 2017
    Date of Patent: September 7, 2021
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Clarissa Nobile, Michael Winter, Charles Craik, Alexander Johnson, Anthony O'Donoghue
  • Patent number: 11098320
    Abstract: The invention relates to high-protein-content soybeans and methods of producing high-protein-content soybeans. The methods can relate to proteome rebalancing and regulating the abscisic acid (ABA) pathway. The methods can relate to modulating transcription factors such as AiP2. AiP2 modification can increase soybean protein content and indicates the strategic path to alter seed protein is contained within the mechanisms of abscisic acid control of seed development.
    Type: Grant
    Filed: February 2, 2018
    Date of Patent: August 24, 2021
    Assignee: ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA
    Inventor: Eliot M. Herman
  • Patent number: 11089348
    Abstract: Aspects of the subject disclosure may include, for example, detecting, by a processing system including a processor, a transmission of a signal that identifies an advertisement, transmitting, by the processing system, a first indication of having detected the signal, and transmitting, by the processing system, a second indication of a status of the processing system when the signal is detected. Other embodiments are disclosed.
    Type: Grant
    Filed: October 3, 2018
    Date of Patent: August 10, 2021
    Assignee: AT&T Intellectual Property I, L.P.
    Inventors: Thomas P. Benzaia, Bernard Ku, Lakshminarashimhan Naidu
  • Patent number: 11064670
    Abstract: The present invention is in the field of soybean variety CS1661395, CS1661278, CS1661219, CS1661171, CS1660654, AND/OR CS1661663 breeding and development. The present invention particularly relates to the soybean variety CS1661395, CS1661278, CS1661219, CS1661171, CS1660654, AND/OR CS1661663 and its seed, cells, germplasm, plant parts, and progeny, and methods of using CS1661395, CS1661278, CS1661219, CS1661171, CS1660654, AND/OR CS1661663 in a breeding program.
    Type: Grant
    Filed: January 27, 2020
    Date of Patent: July 20, 2021
    Assignee: Syngenta Crop Protection AG
    Inventor: Joseph William Strottman
  • Patent number: 11046978
    Abstract: This disclosure generally relates to the use of enzyme combinations or recombinant microbes comprising same to make isoprenoid precursors, isoprenoids and derivatives thereof including prenylated aromatic compounds. Novel metabolic pathways exploiting Claisen, aldol, and acyioin condensations are used instead of the natural mevalonate (MVA) pathway or 1-deoxy-d-xylulose 5-phosphate (DXP) pathways for generating isoprenoid precursors such as isopentenyl pyrophosphate (IPP), dimethylallyl pyrophosphate (DMAPP), and geranyl pyrophosphate (GPP). These pathways have the potential for better carbon and or energy efficiency than native pathways. Both decarboxylative and non-carboxylative condensations are utilized, enabling product synthesis from a number of different starting compounds.
    Type: Grant
    Filed: March 15, 2017
    Date of Patent: June 29, 2021
    Assignee: WILLIAM MARSH RICE UNIVERSITY
    Inventors: Ramon Gonzalez, James M. Clomburg, Seokjung Cheong
  • Patent number: 11046965
    Abstract: The present invention provides a method which can replace Agrobacterium techniques and which can efficiently produce transformed cells of a rubber-producing plant. The present invention relates to a method of producing transformed cells of a rubber-producing plant, which includes steps a) to e).
    Type: Grant
    Filed: June 12, 2019
    Date of Patent: June 29, 2021
    Assignee: SUMITOMO RUBBER INDUSTRIES, LTD.
    Inventors: Haruhiko Yamaguchi, Yukino Inoue, Teruhiko Terakawa, Tsubasa Yano
  • Patent number: 11044883
    Abstract: A soybean cultivar designated 1361091 is disclosed. Embodiments include the seeds of soybean 1361091, the plants of soybean 1361091, to plant parts of soybean 1361091, and methods for producing a soybean plant produced by crossing soybean 1361091 with itself or with another soybean variety. Embodiments include methods for producing a soybean plant containing in its genetic material one or more genes or transgenes and the transgenic soybean plants and plant parts produced by those methods. Embodiments also relate to soybean cultivars, breeding cultivars, plant parts, and cells derived from soybean 1361091, methods for producing other soybean cultivars, lines or plant parts derived from soybean 1361091, and the soybean plants, varieties, and their parts derived from use of those methods. Embodiments further include hybrid soybean seeds, plants, and plant parts produced by crossing 1361091 with another soybean cultivar.
    Type: Grant
    Filed: October 17, 2019
    Date of Patent: June 29, 2021
    Assignee: Benson Hill Seeds, Inc.
    Inventor: William K. Rhodes
  • Patent number: 11046971
    Abstract: The present invention refers to a method for controlling undesired vegetation at a plant cultivation site, the method comprising the steps of providing, at said site, a plant that comprises at least one nucleic acid comprising a nucleotide sequence encoding a wild-type hydroxyphenyl pyruvate dioxygenase or a mutated hydroxyphenyl pyruvate dioxygenase (mut-HPPD) which is resistant or tolerant to a HPPD-inhibiting herbicide and/or a nucleotide sequence encoding a wild-type homogentisate solanesyl transferase or a mutated homogentisate solanesyl transferase (mut-HST) which is resistant or tolerant to a HPPD-inhibiting herbicide, applying to said site an effective amount of said herbicide. The invention further refers to plants comprising mut-HPPD, and methods of obtaining such plants.
    Type: Grant
    Filed: April 29, 2014
    Date of Patent: June 29, 2021
    Inventors: Maciej Pasternak, Stefan Tresch, Johannes Hutzler, Jens Lerchl, Thomas Mietzner, Brigitte Weston, Matthias Witschel, Jill Marie Paulik