Means For Intermixing Liquid With Solid Or Different Liquid Patents (Class 604/82)
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Patent number: 8622956Abstract: An injection device including a volume for accommodating a product for administration, a piston for acting upon the product within the volume, and a stopper which can be arranged between an end of the piston facing the product and the product within the volume, wherein the piston includes a piston head configured to be sealed in a gas-tight manner, the piston head being separate from the stopper such that a negative pressure or vacuum region can be developed between the piston head and the stopper.Type: GrantFiled: February 25, 2009Date of Patent: January 7, 2014Assignee: Roche Diagnostics International AGInventor: Ivan Heutschi
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Publication number: 20140005636Abstract: The present invention is directed to a multi-compartment medical device for segregated storage and on demand mixing of at least two components and expression of a resulting mixture from the device having a tubular barrel with an opening and a gasket sealing the rear end through which a plunger is axially slidable within the tubular barrel. At least one bypass is provided in the barrel in order to enable fluid movement of the components between front and rear compartments and rear compartments. The present invention is also directed to methods for the use of such devices.Type: ApplicationFiled: June 29, 2012Publication date: January 2, 2014Inventors: Yi-Lan Wang, Leo B. Kriksunov
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Publication number: 20130338633Abstract: Methods and compositions for treating post-myocardial infarction damage are herein disclosed. In some embodiments, a carrier with a treatment agent may be fabricated. The carrier can be formulated from a bioerodable, sustained-release substance. The resultant loaded carrier may then be suspended in at least one component of a two-component matrix system for simultaneous delivery to a post-myocardial infarction treatment area.Type: ApplicationFiled: May 20, 2013Publication date: December 19, 2013Applicant: Abbott Cardiovascular Systems, Inc.Inventors: Shubhayu Basu, Gregory Waimong Chan
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Patent number: 8603028Abstract: In one embodiment, the handheld injection device includes a first housing having a first axis and a second housing having a second axis. In one embodiment, the second housing is configured to support a needle. In one embodiment, the first axis and a second axis form an adjustable angle between about 180 degrees and about 90 degrees.Type: GrantFiled: March 16, 2012Date of Patent: December 10, 2013Assignee: Allergan, Inc.Inventors: Christopher S. Mudd, Mitchell H. Babkes, Zachary P. Dominguez, Michael J. Prichard, Martha E. Llewellyn, Shaohui Qiu, Lee F. Powers, Brett R. Johnson
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Publication number: 20130324473Abstract: The invention relates to the preparation and provision of a gelling collagen composition that instantaneously forms a collagen matrix, and means for the preparation and use thereof, in particular as part of a therapeutic treatment.Type: ApplicationFiled: January 26, 2012Publication date: December 5, 2013Applicant: AMEDRIX GmbHInventor: Thomas Graeve
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Publication number: 20130317477Abstract: An apparatus includes a medicament container, a first elastomeric member, a second elastomeric member and a stopper. The first and second elastomeric members are disposed within the medicament container. The first elastomeric member, a first portion of the medicament container and the second elastomeric member collectively define a medicament volume. The stopper is coupled to a distal end portion of the medicament container. The second elastomeric member, a second portion of the medicament container and the stopper collectively define a vent volume. A first retainer of the stopper is configured to engage a first portion of a carrier to limit movement of the medicament container when in a first position. A second retainer of the stopper is configured to engage a second portion of the carrier to limit movement of the medicament container when in a second position.Type: ApplicationFiled: March 14, 2013Publication date: November 28, 2013Applicant: INTELLIJECT, INC.Inventor: Intelliject, Inc.
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Publication number: 20130315854Abstract: A composition for use in treating soft tissue in a living creature with a bulking material prepared in situ from a composition of an addition curable polysiloxane system.Type: ApplicationFiled: May 23, 2013Publication date: November 28, 2013Inventor: Jan Albert de VRIES
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Publication number: 20130317423Abstract: A dispensing device is disclosed having an ampoule with at least four storage lumens extending axially along the length of an ampoule body, a mixing tip coupled to a distal end of the storage lumens, the mixing tip having at least four gasket seats formed therein, each gasket seat corresponding to one of the storage lumens, and an outlet lumen in fluid communication with the storage lumens.Type: ApplicationFiled: January 10, 2013Publication date: November 28, 2013Applicant: RESTEK CORPORATIONInventors: Thomas E. KANE, Brian A. JONES
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Patent number: 8585691Abstract: Thermochemical ablation techniques may provide ablation of bodily tissue using chemical reaction energy.Type: GrantFiled: December 17, 2012Date of Patent: November 19, 2013Assignee: Regents of the Univeristy of MinnesotaInventor: Erik N. K. Cressman
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Patent number: 8579855Abstract: A method of storing and delivery a drug, such as by lyophilizing and reconstituting, comprises performing both storing and delivering with the same container closure assembly. The container closure is assembled in a preparation configuration during which lyophilization occurs. After lyophilizing, the powdered drug is forced into a spiral channel in the container closure assembly by a plunger. The plunger leaves substantially no head space for the powdered drug, and the assembly is sealed thereby now being in the storage configuration. For delivery of the stored powdered drug, a syringe of diluent is introduced to the container assembly thereby changing the assembly to the delivery configuration. The spiral channel is continuous between an input end and a delivery end with the delivery end being in fluid communication with a delivery outlet of the assembly. The assembly includes a diluent flow path that forces the diluent into a spiral channel at only the input end.Type: GrantFiled: June 13, 2011Date of Patent: November 12, 2013Inventors: Byeong Seon Chang, Roger Wongjung Liu
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Publication number: 20130296778Abstract: A drug delivery device (1) for mixing substances and administering a final drug product, the device comprising a container having compartments for individual storage of the substances and means for allowing the substances to be mixed. Pistons are arranged in the container and adapted to be moved by a piston driver which is operatively coupled with a user manipulable wheel (106).Type: ApplicationFiled: December 6, 2011Publication date: November 7, 2013Applicant: NOVO NORDISK HEALTHCARE AGInventors: Camilla Damgaard-Soerensen, Lars Eilertsen, Soeren Kjellerup Hansen
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Publication number: 20130296777Abstract: An apparatus for percutaneous delivery of a sealant comprising: at least two fluid reservoirs, an introducer needle having a distal tip that is in fluid communication with at least one reservoir, a fluid delivery tube that is in fluid communication with a second reservoir, wherein the fluid delivery tube has a tip and wherein the fluid delivery tube is configured so that the tip of the fluid delivery tube does not extend past the distal tip of the introducer needle during use.Type: ApplicationFiled: March 18, 2013Publication date: November 7, 2013Inventor: SPINAL RESTORATION, INC.
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Patent number: 8568367Abstract: An automatic medicament injector having a compartment for a dry medicament component and a compartment for a wet medicament component. The two compartments are separated by a seal structure that converts from a sealing condition to a mixing condition when the device is activated. The seal structure includes a wiper that scrapes the interior walls in the dry component compartment to prevent the dry component from accumulating at the seal/glass interface. A tapered insert funnels the mixed medicament components to an attached needle assembly, but can be removed when the device is filled. A filter is provided between the medicament compartments and the needle assembly. A chamber between the filter and the needle allows for better flow through the filter. An actuation assembly drives the seal structure into the mixing condition and forces the mixed medicament through the needle and into the user.Type: GrantFiled: January 26, 2007Date of Patent: October 29, 2013Assignee: Meridian Medical Technologies, Inc.Inventors: Steven M. Griffiths, Robert L. Hill
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Patent number: 8567419Abstract: An apparatus capable of cleaning a material includes pipes arranged in a first barrel; and through holes defined in a second barrel. The second barrel is received in the first barrel. The apparatus further includes a driver comprising a drive shaft, the drive shaft extending through the first barrel and being connected to the second barrel. A fluid container is included store fluid, an air controller is provided air-dry the material. Before washing the material, the second barrel is driven by the driver to cause each of the through holes to disengage from a corresponding pipe. After washing the material, the second barrel is driven by the driver to cause each of the through holes to engage with the corresponding pipe.Type: GrantFiled: May 12, 2010Date of Patent: October 29, 2013Assignee: Hon Hai Precision Industry Co., Ltd.Inventor: Shao-Kai Pei
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Patent number: 8568446Abstract: A surgical device comprises a housing, a plurality of media reservoirs, an end effector, and a pumping device. Each media reservoir is configured to receive at least one component of a tissue repair composition. The end effector is configured for insertion into a lumen to deliver a tissue repair composition into that lumen. The end effector has at least one fluid conduit and at least one orifice in communication with the fluid conduit. The pumping device is operable to urge a tissue repair composition comprising at least a portion of the contents of the plurality of media reservoirs through the fluid conduit of the end effector such that the tissue repair composition is expelled from the at least one orifice. The media reservoirs may contain medical fluid components such as viable cells and scaffold material to repair a fistula or address some other condition in a patient.Type: GrantFiled: May 13, 2010Date of Patent: October 29, 2013Assignee: Ethicon Endo-Surgery, Inc.Inventors: Takashi Kurokawa, Christopher W. Widenhouse, Agnieszka Seyda, Jeffrey S. Swayze, Foster B. Stulen, Mark H. Ransick, Richard W. Timm, Shailendra K. Parihar, Shelby L. Cook Kornbluth
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Publication number: 20130274656Abstract: The apparatus (1) is designed to mix at least two ingredients coming from at least two distinct reservoirs (2, 3). It has at least two distinct orifices (6, 7) suitable for being connected to the reservoirs (2, 3), a motor-driven pump (15), a fluid-connection selector (9) including at least one network of through channels (12) suitable for putting at least one of the orifices into communication with the pump (15), the fluid-connection selector (9) being arranged to be movable between a plurality of positions in order to make it possible, selectively and by means of the pump (15), to transfer at least one ingredient from one orifice to the other orifice or towards the pump (15) and to blend the resulting mixture.Type: ApplicationFiled: December 19, 2011Publication date: October 17, 2013Applicant: EVEONInventors: Christophe F. Dehan, Didier Lamy
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Patent number: 8545440Abstract: Devices and systems for injecting fluids and/or other materials into a targeted anatomical location, in particular, a joint or intra-articular space, include a handpiece assembly having a needle extending from its distal end, a fluid delivery module comprising a cassette and a fluid transfer device. A conduit is generally configured to place the fluid delivery module in fluid communication with the handpiece assembly. Medicaments, formulations and/or other fluids or materials contained within vials that are secured to a cassette or other portion of the fluid delivery module can be selectively delivered into an anatomy through a needle located at the distal end of the handpiece assembly. In some embodiments, ultrasound or other imaging technologies can be used to locate a joint or other targeted anatomical location.Type: GrantFiled: June 24, 2010Date of Patent: October 1, 2013Assignee: Carticept Medical, Inc.Inventors: Timothy Patrick, Richard Knostman, Michael Axelrod, Carribeth Ramey
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Patent number: 8544682Abstract: A device for the serial ejection of at least two fluid components comprises a spacer (19) providing at least two states, i) a first state allowing a front piston (7) to be displaced forwards by action on a rear piston (17) while a fluid volume is retained in a rear chamber (5) and ii) a second state allowing the rear chamber to volumetrically shrink while fluid is transferred past (or through) the front piston thereby enabling the use of a liquid, initially provided in only the rear chamber, for the dual purposes of mixing and rinsing.Type: GrantFiled: November 21, 2008Date of Patent: October 1, 2013Assignee: Swedish Orphan Biovitrum ABInventors: Jonas Fransson, Birger Hjertman
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Publication number: 20130253254Abstract: A system for delivering fluid to a patient includes a container suitable for holding a fluid and an enclosure to shield the fluid. The system further includes a pump device capable of pumping fluid from the container and delivering the fluid to the patient, and the container adapted to be attachable to the pump device.Type: ApplicationFiled: May 21, 2013Publication date: September 26, 2013Applicant: MEDRAD, Inc.Inventors: Arthur E. Uber, III, Alan D. Hirschman, David M. Griffiths, Frederick W. Trombley, III, David M. Reilly
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Patent number: 8534575Abstract: A spraying device having a spray head for spraying at least one component comprises at least one substance component duct (6, 6?; 20), the component outlet (8, 8?; 23, 23?) of which leads out of a spray head tip (7). An annular duct (12) for a pressurized gas surrounds the at least one component duct (6, 6?; 20) at least partially in the longitudinal direction and leads out of the spray head (5) at the spray head tip (7). A pressurized gas supply duct (13) is provided for introducing pressurized gas at the annular duct (12). The annular duct (12) has a plurality of ribs (16, 16?), which divide the annular duct (12) at least in the region of the spray head tip (7) into pressurized gas outlet ducts (17, 17?) that are separated from each other.Type: GrantFiled: October 23, 2009Date of Patent: September 17, 2013Assignee: Medmix Systems AGInventor: William Brem
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Patent number: 8529502Abstract: A transfer system (100, 100?, 100?) adapted to allow first contents of a first container (20) and second contents of a second container (30) to mix to form a material. The mixed material is retrieved to a syringe (40). The transfer system (100, 100?, 100?) comprises first (17) and second (18) flow control members for controlling fluid flow between the containers (20, 30) and the syringe (40). The invention further relates to a drug mixing kit comprising a container unit containing first and second containers, and a transfer unit comprising ports for receiving the containers and a syringe and a number of flow channels. The container unit and the transfer unit are adapted to be coupled together to form a drug mixing kit.Type: GrantFiled: April 23, 2007Date of Patent: September 10, 2013Assignee: Novo Nordisk Healthcare AGInventor: Bo Radmer
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Publication number: 20130231609Abstract: A device for mixing and delivering a mixture of fluids to a target site includes a tube for containing the mixture. A compressible auger for mixing the fluids is movably disposed within the tube, one end of the auger being free at the distal end of the tube. A plunger is also movable within the tube in communication with the other end of the auger. When the plunger is moved axially within the tube the auger also moves axially and the auger is compressed to dispense the fluid. The mixing and delivery device can be used with an apparatus for the arthroscopic delivery of a tissue repair material to a repair site. The apparatus includes a first sheath and a second sheath removably attached to the first sheath for delivering the tissue repair material to the repair site.Type: ApplicationFiled: October 28, 2012Publication date: September 5, 2013Applicant: Children's Medical Center CorporationInventors: Alexander H. Slocum, Matthew R. Carvey, Alexey Salamini, Ying-Chih Wang, Martha M. Murray, Daniel G. Walker
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Patent number: 8523806Abstract: A sprayer is capable of inhibiting or preventing clogging occurring in a nozzle upon ejection of a liquid through the nozzle. A sprayer includes liquid supply for separately supplying a first liquid and a second liquid different in liquid composition, and a nozzle. The nozzle includes a first flow path and a second flow path along which passes the first liquid and the second liquid supplied from the liquid supply. In addition, the nozzle includes a third flow path along which passes a gas. A merge part is provided at which the first flow path and the second flow path merge at their respective halfway parts. A vent is provided at the merge part for allowing the gas which has passed through the third flow path to flow into the merge part.Type: GrantFiled: March 11, 2009Date of Patent: September 3, 2013Assignee: Terumo Kabushiki KaishaInventor: Koichi Hayakawa
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Patent number: 8523805Abstract: A system for expressing two materials onto a selected site is disclosed. The system can include a syringe that is operable to maintain two separated materials substantially separate until a selected time. The system can further include a tip portion operable to direct the two materials, either mixed or unmixed, to a selected site. The materials can include tissue sealants, growth factors, or other appropriate materials to be directed to a selected site.Type: GrantFiled: October 29, 2008Date of Patent: September 3, 2013Assignee: Biomet Biologics, LLCInventor: Jason Chavarria
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Patent number: 8523807Abstract: A transfer and mixing device which utilizes a by-pass cartridge and a syringe. After mixing the dry component and the diluent in the by-pass cartridge, the mixture can be passed to a syringe which includes a syringe plunger having a fluid passageway therein with a hydrophobic membrane covering the passageway. The mixture can be transferred back and forth between the by-pass cartridge and the syringe through a small bore to achieve mixing, particularly in the case of microspheres held in suspension.Type: GrantFiled: January 22, 2008Date of Patent: September 3, 2013Assignee: Duoject Medical Systems Inc.Inventors: David L. Reynolds, Daniel MacDonald, Roger McCarthy
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Patent number: 8517226Abstract: The dispensing assembly with a syringe comprising storage container configured to receive a powdery or granular material and a piston that is connected to a hollow ram. In order to supply a liquid to the powdery or granular material, both the hollow ram and the piston have through-going, sealable longitudinal bores. Due to the fact that the liquid is filled in from the inlet side, a complete de-aeration of the mixture can be ensured.Type: GrantFiled: August 6, 2007Date of Patent: August 27, 2013Assignee: Medmix Systems AGInventor: Wilhelm A. Keller
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Publication number: 20130218074Abstract: A medicament delivery device includes a housing; a drive force mechanism slidable in the housing's distal part; a member connected to the drive force mechanism for holding it in a loaded state and axially movable in relation to the distal part a predetermined distance by the housing's proximal part when the parts are moved toward each other; and an actuation member to be biased in relation to the distal part from a non-operating position partially protruding from the distal part to an operating position confined within the distal part. The actuation member can release the drive force mechanism from its loaded state, and is resiliently connected to the distal part such that it is always recoiled after being biased regardless of whether the actuation mechanism is released. The drive force mechanism is released only after the holding member moves and the actuation member is biased from non-operating to operating position.Type: ApplicationFiled: August 23, 2011Publication date: August 22, 2013Applicant: SHL GROUP ABInventors: Anders Holmqvist, Sebastian Karlsson
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Patent number: 8512277Abstract: Volume filling and/or augmentation are improved by harvesting live dermis from a donor and processing the dermis for re-injection into the donor. A variety of kits, tools, and methods are described for harvesting, processing, and using injectable dermis in volume filling procedures.Type: GrantFiled: September 11, 2012Date of Patent: August 20, 2013Assignee: Lipovera, LLCInventor: Daniel A. Del Vecchio
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Publication number: 20130211375Abstract: Syringe assemblies are provided that can include a valve within a plunger having a fluid channel extending longitudinally therethrough and along the channel, the valve including a piston extending substantially normally to the channel and configured to slidably engage the plunger along the extension. Syringe assemblies can also include: a syringe barrel having a first cross sectional diameter; a syringe piston configured to operatively couple with the barrel; a fluid channel extending the length of the piston; a vial port extending from an end of the piston, the vial port having a second cross sectional diameter, the second diameter being greater than the first diameter. Methods for controlling fluid along a fluid channel within a syringe plunger are also provided. The methods can include extending a piston in one direction normally to the fluid channel to provide fluid communication between two sections of the fluid channel.Type: ApplicationFiled: March 15, 2013Publication date: August 15, 2013Applicant: HYPROTEK, INC.Inventor: Hyprotek, Inc.
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Publication number: 20130211249Abstract: The invention features catheters, hydrogel compositions, and methods that useful for the treatment of various conditions and diseases. The invention also provides kits and instructions for use.Type: ApplicationFiled: July 22, 2011Publication date: August 15, 2013Applicant: The Johns Hopkins UniversityInventors: Bradley Powers Barnett, Rex C. Yung, Philippe Gailloud
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Patent number: 8506518Abstract: A medical/surgical irrigator with a handpiece for discharging a lavage solution. There is reservoir in which a therapeutic agent is stored. The therapeutic agent can be selectively mixed with the lavage solution to form a blended solution. The mixing can be performed selectively so as to make it possible to sequentially apply the blended solution or a basic (lavage only) solution.Type: GrantFiled: March 9, 2012Date of Patent: August 13, 2013Assignee: Stryker CorporationInventors: Bruce Henniges, Richard F. Huyser
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Patent number: 8500680Abstract: A method including introducing a treatment agent at a treatment site within a mammalian host; and introducing a bioerodable gel material at the treatment site. An apparatus including a first annular member having a first lumen disposed about a length of the first annular member and a first entry port at a proximal end of the first annular member, and a second annular member coupled to the first annular member having a second lumen disposed about a length of the second annular member and a second entry port at a proximal end of the second annular member, wherein the first annular member and the second annular member are positioned to allow a combining of treatment agents introduced through each annular member at the treatment site.Type: GrantFiled: January 11, 2008Date of Patent: August 6, 2013Assignee: Abbott Cardiovascular Systems Inc.Inventors: Charles D. Claude, Paul J. Kawula, Syed Faiyaz Ahmed Hossainy, Kimchi Tran
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Patent number: 8491526Abstract: A surgical device comprises a housing, a bioprocessing module, an end effector, and a pumping device. The bioprocessing module comprises media reservoirs, fluid conduits in communication with the reservoirs, and a port through which media is expelled. The end effector is configured for insertion into a lumen and delivering a tissue repair composition into that lumen. The end effector has at least one fluid conduit extending therethrough and at least one orifice in communication with the fluid conduit. The fluid conduit in the first end effector is in fluid communication with the port on the bioprocessing module. The pumping device is operable to urge a tissue repair composition comprising at least a portion of the contents of the media reservoirs through the fluid conduit of the first end effector such that the tissue repair composition is expelled from the at least one orifice.Type: GrantFiled: May 13, 2010Date of Patent: July 23, 2013Assignee: Ethicon Endo-Surgery, Inc.Inventors: Michael D. Cronin, Jerome R. Morgan, Patrick D. Dugan, Rebecca J. Mollere, John B. Schulte, David A. Witt, Joseph P. Schowalter, Eugene L. Timperman, Prasanna Malaviya, Shailendra K. Parihar, Shelby L. Cook Kornbluth, Richard W. Timm, Donna L. Korvick, James A. Woodard, Jr., Peter K. Shires, Barbara L. Mattson, Matthew C. Miller, Frederick E. Shelton, IV
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Patent number: 8491530Abstract: The invention relates to an automatic injection device (1) for a product contained in a container (50), comprising: a housing (8, 19) receiving the container (50), the container being movable between an initial position and an insertion position, triggering means (23) for initiating the movement of said container (50) from its initial position to its insertion position, said triggering means (23) being in one of a passive state, in which application of a force on said triggering means does not initiate movement of said container (50), and an active state, in which application of said force on said triggering means does initiate said movement, and a safety shield (10) movable with respect to said housing (8, 19) between a first position and a second position, movement of said safety shield (10) from its first position to its second position placing said triggering means (23) in its active state, characterized in that said device comprises: an indicator (19c, 13) that provides an indication to a user of theType: GrantFiled: September 25, 2007Date of Patent: July 23, 2013Assignee: Becton Dickinson FranceInventor: Lionel Maritan
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Patent number: 8486006Abstract: A medical injector is provided herein which includes a body; a slidable button at least partially disposed in the body; a displaceable plunger disposed in the body; a spring disposed to advance the plunger; and, a releasable retainer for retaining the plunger in a first state against force of the spring. Upon a predetermined extent of sliding movement of the button, the button engages the releasable retainer so as to cause the releasable retainer to release the plunger thus allowing the spring to advance the plunger. Advantageously, the subject invention provides a medical injector having an automated plunger drive which is triggered upon button activation, thereby minimizing premature or failed activations.Type: GrantFiled: September 18, 2009Date of Patent: July 16, 2013Assignee: Becton, Dickinson and CompanyInventor: Richard A. Cronenberg
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Publication number: 20130178827Abstract: Compositions and methods are provided for treating joint conditions, such as osteoarthritis and/or the pain associated therewith. The compositions and methods utilize a first component, namely hyaluraonic acid (“HA”), in combination with a lyophilized second component that is effective to at least temporarily reduce the viscosity of the HA. In an exemplary embodiment, the second component is one or more glycosaminoglycans (“GAG”), such as chondroitin sulfate (“CS”), including CS4 and/or CS6, dermatan sulfate, heparin, heparan sulfate, and keratan sulfate.Type: ApplicationFiled: January 25, 2013Publication date: July 11, 2013Applicant: DEPUY MITEK, LLCInventor: DEPUY MITEK, LLC
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Patent number: 8480617Abstract: The invention relates to an injection device for the needle-free injection of a medium. Said injection device comprises an injector device and an ampoule unit, said ampoule unit comprising a base (4) holding the medium to be injected. Said base comprises a jacket (5) which exerts pressure on the base, and jacket completely enveloping the base in the longitudinal axial direction.Type: GrantFiled: November 16, 2006Date of Patent: July 9, 2013Assignee: Painless Tech GmbHInventors: Benedikt Lenzner, Stephan Theuer, Bernd Störmer-Talleur, Dirk Schulz
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Publication number: 20130172255Abstract: Methods and compositions are disclosed for an intra-articular injection for the treatment of osteoarthritis. The methods and compositions comprising combinations of hyaluronic acid and a bone morphogenetic protein, like rhGDF-5, can be useful for any synovial joint, including the knee, shoulder, hip, ankle, hands, spinal facet, or temporomandibular joint, both for the relief of pain and for slowing disease progression.Type: ApplicationFiled: March 7, 2013Publication date: July 4, 2013Applicant: DEPUY MITEK, LLCInventor: DePuy Mitek, LLC
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Publication number: 20130171156Abstract: Uses of BMP-1 isoforms for diagnosing and treating defects and disorders of bone and soft tissues are described. Also described is a newly isolated variant of the BMP-1 isoform BMP-1-3.Type: ApplicationFiled: February 28, 2013Publication date: July 4, 2013Applicant: GENERA ISTRAZIVANJA D.O.O.Inventor: Genera Istrazivanja D.O.O.
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Patent number: 8475404Abstract: A device for mixing and transferring is described. The device comprises a housing having open ends, a container accessing member having at least one fluid conduit therethrough, the container accessing member extending generally outwardly from one end of the housing. The device comprises a fluid delivery device accessing member having at least one fluid conduit therethrough, the fluid delivery device accessing member extending generally outwardly from the other end of the housing having the container accessing member, the fluid delivery device accessing member and the container accessing member in fluid communication therewith.Type: GrantFiled: August 21, 2008Date of Patent: July 2, 2013Assignee: Yukon Medical, LLCInventors: David L. Foshee, Theodore J. Mosler, Bryan J. Peters, Nicholas J. Jardine, Todd M. Korogi
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Publication number: 20130165853Abstract: A syringe kit for mixing two medicinal fluids includes first and second barrels adapted to contain medicinal fluids therein. The first barrel includes a connecting tube portion at a tip portion thereof having a male screw on an outer periphery, and an inner tapered surface on an inner periphery. The second barrel includes a nozzle portion at a tip portion thereof having a screw tube portion with a female screw on an inner periphery thereof freely engageable with the male screw, and an outer tapered surface fitting to the inner tapered surface on the inner periphery. At least a surface of the male screw and the outer periphery of the connecting tube portion of the first barrel, or a surface of the female screw and the inner periphery of the screw tube portion of the second barrel are roughened to a surface roughness in a range between Ra1.0 and Ra2.0.Type: ApplicationFiled: December 10, 2012Publication date: June 27, 2013Applicant: DAIKYO SEIKO, LTD.Inventor: Daikyo Seiko, Ltd.
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Patent number: 8469924Abstract: Apparatus and methods for generating foam are disclosed. The inventions can be used for generating foam for sclerotherapy. A foaming element can be agitated within a foaming chamber by a drive unit that does not touch the foaming element, but actuates it from outside the foaming chamber. The foaming element and drive unit can be magnetically coupled. A syringe can be used to form a foaming chamber.Type: GrantFiled: April 4, 2007Date of Patent: June 25, 2013Assignee: Covidien LPInventors: Hoa D. Nguyen, Michael S. Mirizzi
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Patent number: 8460235Abstract: A dispensing assembly for two components including a double syringe, a mixer, and a transfer device interposed between the double syringe and the mixer. The transfer device (3) includes a transfer unit with a transfer tube having a mixer at one end and a coupling area with an inlet portion at the other end. The coupling area is provided with coupling means which cooperate with coupling means on the double syringe. At least around the coupling area of the transfer unit, a support is arranged which is attachable to the double syringe.Type: GrantFiled: June 9, 2008Date of Patent: June 11, 2013Assignee: Medmix Systems AGInventor: Wilhelm A. Keller
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Publication number: 20130144249Abstract: Devices, systems and methods are disclosed for delivering adhesive material to a patient site. A delivery device includes a housing and a nozzle. Adhesive material exits the end of the nozzle such as to adhesively attach tissue to tissue or a material or device to tissue.Type: ApplicationFiled: November 30, 2010Publication date: June 6, 2013Applicant: DARTMOUTH MEDICAL RESEARCH LIMITEDInventors: Paul V. Fenton, J. Christopher Flaherty, Paul A. Westhaver, Anshuman Shrivastava
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Patent number: 8454558Abstract: A hollow inner plunger for use within a syringe-in-syringe mixing system for mixing a two-part dental composition. The hollow inner plunger includes a body having a continuous cylindrical wall defining an internal chamber for containing a first component. The body includes a proximal end and a distal end. A sealing plug and rupturable membrane are disposed at the distal end of the body, and the sealing plug and rupturable membrane are integrally formed together as a single piece (e.g., formed of a single piece of elastomeric material). An associated syringe-in-syringe mixing system includes a first plunger, the hollow inner plunger, and a syringe barrel configured to contain a second component. When assembled, the first plunger is slidably disposed within the hollow inner plunger, and the hollow inner plunger is slidably disposed within the syringe barrel. The two components are initially separated by the rupturable membrane.Type: GrantFiled: April 26, 2007Date of Patent: June 4, 2013Assignee: Ultradent Products, Inc.Inventors: Neil Jessop, Bruce S. McLean, Jared Sheetz
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Patent number: 8449494Abstract: A device and a method for preparing foam are provided. The device includes a first housing having a first chamber therein and a first movable member positioned at least partially within the first housing. The device also includes a second housing having a second chamber therein, the second chamber being selectively and operably connectable to the first chamber. The second housing further includes a biasing member and a second movable member therein, the biasing member biasing the movable member toward a first end portion of the second housing. The device includes a valve operably connected to the first chamber and the second chamber and movably positionable to selectively control the connection between the first chamber and the second chamber and a handle operably connected to the first movable member and movable to bias the first movable member toward a first end portion of the first housing.Type: GrantFiled: December 16, 2009Date of Patent: May 28, 2013Assignee: Cook Medical Technologies LLCInventor: Jeffry S. Melsheimer
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Publication number: 20130131589Abstract: In one embodiment, the handheld injection device includes a first housing having a first axis and a second housing having a second axis. In one embodiment, the second housing is configured to support a needle. In one embodiment, the first axis and a second axis form an adjustable angle between about 180 degrees and about 90 degrees.Type: ApplicationFiled: March 16, 2012Publication date: May 23, 2013Applicant: ALLERGAN, INC.Inventors: Christopher S. Mudd, Mitchell H. Babkes, Zachary P. Dominguez, Michael J. Prichard, Martha E. Llewellyn, Shaohui Qiu, Lee F. Powers, Brett R. Johnson
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Patent number: 8444597Abstract: A system and method for a patch-like, self-contained multi-component substance infusion device which provides one or more substantially hidden patient needles which can be placed in fluid communication with a fluid reservoir assembly that includes a rigid bladder portion used in conjunction with a non-distensible bladder film, such as a metallized film. The device can be attached to a skin surface via an adhesive contact and a pressurization system provides a pressure to the contents of a fluid reservoir assembly. Improvements to dry powdered formulations for reconstitution for preferred use in the device are also disclosed.Type: GrantFiled: June 27, 2011Date of Patent: May 21, 2013Assignee: Becton, Dickinson and CompanyInventors: Vincent J. Sullivan, Ge Jiang, Matthew S. Ferriter, Kenneth G. Powell, P. Spencer Kinsey, Carl R. Sahi, John M. Polidoro
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Publication number: 20130116617Abstract: In one aspect of the invention, a needle assembly is provided, including: a body having a proximal end, a distal end, and a channel located therebetween, the body being configured to be mounted to an injector; a needle fixed to the body, the needle having proximal and distal ends, the distal end extending distally from the distal end of the body and being formed for insertion into a patient, the proximal end of the needle being in communication with the channel; and, a filter disposed in the channel proximally of the proximal end of the needle. Advantageously, a needle assembly is provided which permits mixing of at least two substances in preparation for injection, without modification to the associated injector.Type: ApplicationFiled: July 22, 2010Publication date: May 9, 2013Applicant: BECTON, DICKINSON AND COMPANYInventors: Frank Martin, Richard J. Klug, M. Ishaq Haider
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Patent number: 8435210Abstract: Fluid control device (70) including a housing (31) with a syringe port (33) for receiving a syringe, a vial adapter port (36) with a vial adapter (86) for snap fit receiving a vial, and a drug administration port (34) for administering a liquid drug. The vial adapter is intended to be rotationally detached after a mixing procedure for discarding together with a spent vial. The fluid control device additionally includes a manually depressed actuator (74) for sealing pathways which may lead to leakage of liquid drug subsequent to vial adapter detachment, thereby facilitating their use for handling and administration of hazardous liquid drugs. The manually depressed actuator preferably precludes vial adapter detachment prior to actuation, thereby ensuring failsafe operation.Type: GrantFiled: April 16, 2008Date of Patent: May 7, 2013Assignee: Medimop Medical Projects Ltd.Inventors: Freddy Zinger, Igor Denenburg