Abstract: Fluid control device (70) including a housing (31) with a syringe port (33) for receiving a syringe, a vial adapter port (36) with a vial adapter (86) for snap fit receiving a vial, and a drug administration port (34) for administering a liquid drug. The vial adapter is intended to be rotationally detached after a mixing procedure for discarding together with a spent vial. The fluid control device additionally includes a manually depressed actuator (74) for sealing pathways which may lead to leakage of liquid drug subsequent to vial adapter detachment, thereby facilitating their use for handling and administration of hazardous liquid drugs. The manually depressed actuator preferably precludes vial adapter detachment prior to actuation, thereby ensuring failsafe operation.

Abstract: A gas sterilizable delivery system for a two-part polymer system is provided. The delivery system includes at least two syringe barrels, each barrel being sealed with a gas permeable plunger seal allowing permeation of a sterilant gas to permeate through the plunger seal allowing the entire assembly to be gas sterilized.

Abstract: A diluent/medication mixing syringe assembly is described which includes a cannula which extends through a syringe plunger assembly into a reservoir of the syringe assembly. The cannula facilitates injection of a diluent, medication or other fluid into the fluid reservoir of the syringe assembly immediately prior to use for mixing with a medication in the reservoir. In one embodiment, a mixing element is secured to a distal end of the cannula within the reservoir to improve mixing efficiency.

Abstract: Systems for injecting fluids and/or other materials into a targeted anatomical location, in particular, an intra-articular space, include a handpiece assembly having a proximal end and a distal end, a needle extending from the distal end of the handpiece assembly, a fluid delivery module comprising a cassette and a fluid transfer device. A conduit is generally configured to place the fluid delivery module in fluid communication with the handpiece assembly. Medications, formulations and/or other fluids or materials contained within vials that are secured to the fluid delivery module can be selectively delivered into an anatomy through a needle located at the distal end of the handpiece assembly. In some embodiments, ultrasound or other imaging technologies can be used to locate a joint or other targeted anatomical location.

Abstract: A container usable for lyophilization, storage, and reconstitution of medication having only two parts, one of which is a plug component having a flow path terminating in a side outlet port and a second of which is a barrel component. The barrel component has a spiral mixing channel near its distal end in which powder medication is stored and upon reconstitution, yields a gradient concentration. The inner wall of the barrel includes a longitudinal diluent groove. To connect the plug outlet port with the longitudinal diluent groove, the plug or barrel has a 360° distribution groove encircling the plug and connecting to the plug outlet port. Regardless of what rotational orientation the plug has to the barrel, the diluent will always reach the mixing channel.

Abstract: Systems for injecting fluids and/or other materials into a targeted anatomical location, in particular, an intra-articular space, include a handpiece assembly having a proximal end and a distal end, a needle extending from the distal end of the handpiece assembly, a fluid delivery module comprising a cassette and a fluid transfer device. A conduit is generally configured to place the fluid delivery module in fluid communication with the handpiece assembly. Medications, formulations and/or other fluids or materials contained within vials that are secured to the fluid delivery module can be selectively delivered into an anatomy through a needle located at the distal end of the handpiece assembly. In some embodiments, ultrasound or other imaging technologies can be used to locate a joint or other targeted anatomical location.

Abstract: The invention discloses a hemostatic composition composing chitin or a water insoluble chitin derivative, especially water insoluble chitosan, in particulate form, wherein the composition is present in paste form.

Abstract: An applicator insertable into a living body includes a nozzle having an elongated nozzle main body and a nozzle head on a front end side of the nozzle main body and through which a liquid together with a gas is expelled, with the nozzle main body including a flexible curved section. The applicator also includes an outer tube in which is positioned a portion of the nozzle main body so as to be movable along a longitudinal direction. The angle or degree of curvature of the curved section is changed by inserting the curved section into the outer tube to thereby adjust a direction of the nozzle head relative to a axis of the nozzle main body. In addition, a longitudinally extending gap exists between the outer tube and the nozzle. The gap functions as a discharge path for discharging gas within the body cavity.

Abstract: An apparatus for percutaneous delivery of a sealant comprising: at least two fluid reservoirs, an introducer needle having a distal tip that is in fluid communication with at least one reservoir, a fluid delivery tube that is in fluid communication with a second reservoir, wherein the fluid delivery tube has a tip and wherein the fluid delivery tube is configured so that the tip of the fluid delivery tube does not extend past the distal tip of the introducer needle during use.

Abstract: The invention concerns an injection implant for filling up wrinkles, thin lines, skin cracks and scars, for reparative or plastic surgery, aesthetic dermatology, and for filling up gums in dental treatment. The invention concerns the use of biologically absorbable polymer microspheres or microparticles suspended in a gel. The suspension is produced either ready-for-use or freeze-dried. The biological absorbability of the microspheres is controlled and enables the production of implants having well defined persistence and deliberately limited to 3 years.

Abstract: Disclosed is an applicator device (10) for applying a multi-component fluid, especially a multi-component tissue glue, comprising a plurality of substantially cylindrical supply containers (12) for respectively one component of the fluid to be applied, each supply container (12) having a front end (16) with an outlet opening (18), a rear end (22) opposite to the front end (16), and a slidably displaceable piston (24) arranged within the supply container (12) and having a piston rod (26) extending out of the rear end (22) for operating the piston (24). Moreover, the applicator device includes a manifold (72) having terminal ends (50,58) with a first port for fluid connection with the front ends (16) of the supply containers (12), the manifold (72) further having internal channels (62) extending from the first ports of the terminal ends (50,58) to an outlet site.

Abstract: A method and kit for treating a disc that is leaking nucleus pulposus through at least one defect in the annulus fibrosus. The method includes injecting a fibrin sealant into the disc to reduce at least a portion of the at least one defect, wherein the fibrin sealant injected into the disc comprises fibrinogen and an activating compound, wherein at least a portion of the fibrin forms after injection, with the proviso that a corticosteroid is absent from the fibrin sealant injected into the disc.

Abstract: The invention relates to a single-use injector and to a two-chamber system, wherein at least one first chamber is part of a cylinder-piston unit that can be received in the single-use injector, and wherein the second chamber is part of a container having at least one opening, and closed at least intermittently by means of a stopper and place in a container adapter releasably supported on the single-use injector. To this end, the stopper and the container adapter can be permanently latched to each other. When the container is inserted, the container adapter closes off the opening and displaces the stopper. When the container is inserted into the container adapter, the adapter connects the interior of the cylinder-piston unit to the interior of the container. By means of the present invention, a single-use injector and a two-chamber system having a reduced number of components is developed.

Abstract: Compositions and methods are provided for treating joint conditions, such as osteoarthritis and/or the pain associated therewith. The compositions and methods utilize a first component, namely hyaluraonic acid (“HA”), in combination with a lyophilized second component that is effective to at least temporarily reduce the viscosity of the HA. In an exemplary embodiment, the second component is one or more glycosaminoglycans (“GAG”), such as chondroitin sulfate (“CS”), including CS4 and/or CS6, dermatan sulfate, heparin, heparan sulfate, and keratan sulfate. The composition can optionally include other joint supplements, such as glucosamine (“GlcN”).

Abstract: Disclosed are a sugar-responsive gel and a medicine administering device having a pKa more suitable for use in a body environment and capable of administering medicine more autonomously than before. A sugar-responsive gel and an insulin administering device having a pKa more suitable for use in a body environment and capable of administering insulin more autonomously than before, wherein under a body condition of pKa of 7.4 or less and temperature of 35° C.-40° C., when the glucose concentration increases, insulin can be released from a gel body in response thereto, and when the glucose concentration decreases, insulin release from the gel body can be suppressed.

Abstract: A plunger-barrel apparatus is adapted for use within a syringe-in-syringe mixing system for mixing a two-part composition (e.g., a dental composition). A hollow plunger-barrel body has a continuous cylindrical wall defining an internal chamber for containing a first component. The body includes a plunger receiving end and a dispensing end. An integral sealing plug and rupturable membrane is disposed at the dispensing end of the body and include a sealing plug portion and a rupturable membrane portion that are integrally formed together as a single piece (e.g., formed of a single piece of elastomeric material). An associated syringe-in-syringe mixing system includes a first plunger, the hollow plunger-barrel body as described above adapted to contain a first component, and a syringe barrel configured to contain a second component. When assembled, the first plunger is slidably disposed within the hollow plunger-barrel body, and the plunger-barrel body is slidably disposed within the syringe barrel.

Abstract: An automatic mixing device, an actuating device removably mounted to the automatic mixing device and a retractable syringe having the automatic mixing device are provided. The actuating device has an initially compressed spring and a trigger member that initiates spring decompression to drive depression of a mixing plunger of the automatic mixing device. A seal located in the outer chamber is capable of axial movement upon depression of the mixing plunger, from a first position in sealing engagement with one or more apertures in an inner barrel to a second position intermediate the apertures and vents in an outer barrel. This allows depression of the mixing plunger to force a first substance from the outer chamber through the apertures to mix with a second substance in an inner chamber of the inner barrel. The mixed substance in the inner barrel is then delivered by the syringe with subsequent needle retraction.

Abstract: An applicator assembly for mixing at least a first and second component is provided. The applicator assembly includes a manifold configured for operable engagement with at least a first and second source of component, the manifold including at least a first and second component channel therethrough, an elongated shaft extending distally from the manifold, the elongated shaft including at least a first and second component lumen extending the length thereof, the at least first and second component channels in fluid communication with the at least first and second component channels, a tip assembly defining a first chamber, an intermediate chamber and a final chamber.

Abstract: The present invention relates to a prodrug or a pharmaceutically acceptable salt thereof, comprising a drug linker conjugate D-L, wherein D being a biologically active moiety containing an aliphatic amine group is conjugated to one or more polymeric carriers via dipeptide-containing linkers L. Such carrier-linked prodrugs achieve drug releases with therapeutically useful half-lives. The invention also relates to pharmaceutical compositions comprising said prodrugs and their use as medicaments.

Abstract: A conveyor apparatus and a method for supplying a medicine-solution mixture from a plurality of medicine-active ingredient solutions and additional solution constituents in a body by means of a plurality of feed devices is disclosed. The medicine-active ingredient solutions have different medicine-active ingredient parameters and constituents; the solution constituents have different parameters and constituents. The constituents of at least two medicine-active ingredient solutions and solution constituents are saved in at least one storage device; and are selected by means of one selection device for selection of at least one specific parameter and/or constituent of each medicine-active ingredient solution and/or the solution constituents. By means of a calculating device, at least one additional parameter from all selected parameters is calculated for the control and operation of at least one additional feed device for supplying at least one additional medicine-solution mixture to the body.

Abstract: A system for delivering a cell-slurry to a patient may include a fluid, cells that are non-dissolvable or immiscible in the fluid, thereby forming the cell-slurry, a syringe adapted to contain the cell-slurry and a supernate of the cell-slurry, the syringe defining a first end having an outlet through which the cell-slurry is delivered to the patient, a fluidizing system associated with the syringe and adapted to effect dilation of the cell-slurry with a portion of the supernate, to form a dilated cell-slurry, the dilated cell-slurry being transferred from the fluidizing system to the syringe, while maintaining at least a portion of the supernate, the cell-slurry and supernate being transferred from the fluidizing system to the syringe, a pressurizing mechanism adapted to create a pressure to cause the dilated cell-slurry contained within the syringe to flow for delivery to the patient and a control unit in communication with and adapted to control the fluidizing system, the pressurizing mechanism and movemen

Abstract: The invention relates to a two-chamber syringe device comprising a cylinder element (2), a closure element (6), two plungers (3) and (4) and optionally an intermediate plunger (3a), wherein one or more fluid-tight, gas-permeable membranes (8) and optionally valve membranes (15) are arranged in the wall of the cylinder element (2) or in the closure element (6), allowing gas in the chambers to escape from the cylinder element (2) when the plungers (3), (3a) and (4) are displaced in the distal direction.

Abstract: A method and apparatus for applying a sealant includes a first chamber that retains a first substance. A second chamber retains a second substance, wherein the second chamber is in selective fluid communication with the first chamber. A third chamber retains a third substance. A first actuator is configured to cause fluid communication of the first and second chambers to allow the first and second substances to comingle and form a first mixture. A second actuator is configured to urge the first mixture and the third substance out of the sealant application apparatus.

Abstract: A syringe includes a first fluid conduit and a second fluid conduit. The first fluid conduit includes two chambers for accommodating two substances of a plurality of substances. The second fluid conduit is disposed adjacent the first fluid conduit and has a chamber for accommodating one substance of the plurality of substances. The syringe may include a third fluid conduit. Each substance is intermixable to form a discharge material upon advancement of a plunger operably associated with each fluid conduit. The discharge material is defined by the intermixed composition of predetermined volumes of the substances the fluid conduits. The discharge material may be a hydrogel. A connecting tip may be operably associated with each fluid conduit. A syringe may include an end cap disposed on the end of each of the fluid conduits. The end cap may have a venting feature for enabling gas venting while preventing discharge until desired.

Abstract: The present invention relates to an injection device for manually penetrating a needle arranged to said device and automatic injecting a medicament mixture, the device being of the type comprising: a first housing part into which a multi-chamber container is arranged and a second housing part which can be displaced relative to said first housing in order to mix at least two substances arranged inside said container; a plunger rod arranged to act on said container, drive force means capable of pushing said plunger rod for acting on said container, an activation member comprising flexible locking means releasibly connected to said plunger rod for holding said plunger rod and thereby said drive force means in a pre-tensioned state, and a push button protruding from said second housing part; and a locking member being arranged around said activation member and being axially slidable in relation to said activation member between a first position wherein said locking member completely surrounds said locking means a

Abstract: A device for priming and venting a hazardous drug within an intravenous administration set. The device includes various access ports and fluid channels to permit direct injection of a hazardous drug into the fluid reservoir, while eliminating the possibility of undesirable exposure to the hazardous drug. The device further includes priming and flushing ports to enable flushing of a hazardous drug from the system following an infusion procedure.

Abstract: The present invention relates to a prodrug or a pharmaceutically acceptable salt thereof, comprising a drug linker conjugate D-L, wherein D being a biologically active moiety containing an aromatic amine group is conjugated to one or more polymeric carriers via dipeptide-containing linkers. Such carrier-linked prodrugs achieve drug releases with therapeutically useful half-lives. The invention also relates to pharmaceutical compositions comprising said prodrugs and their use as medicaments.

Abstract: A method of reconstituting and administering an injectable fluid distributed to practitioners in dry-form includes receiving a drug or medicine in dry form, selecting a reconstitution concentration for the drug or medicine, reconstituting a desired number of units of the drug or medicine by adding diluent to the dry-form drug or medicine, selecting a syringe having units marked according to the selected reconstitution concentration, drawing up a desired number of drug or medicine units using the selected syringe, and administering a desired number of units according to the unit markings on the selected syringe. Such a syringe includes a barrel, a plunger assembly that has a plunger handle and a piston, a needle, and a needle cap. The syringe includes a visual indicia, representing a first drug concentration contained in the barrel, that is distinguishable from a corresponding visual indicia, on a second syringe, representing a second drug concentration.

Abstract: The present embodiments provide apparatus and methods suitable for containing and delivering a therapeutic agent to a target site. The apparatus generally comprises at least one container for holding a therapeutic agent, and a pressure source for facilitating delivery of the therapeutic agent. In one embodiment, the pressure source may be placed in selective fluid communication with a proximal region of the container and fluid from the pressure source may flow through at least a portion of the container to urge the therapeutic agent through the container towards the target site. In an alternative embodiment, the pressure source may be selectively in fluid communication with either a first hollow tube and the container so that therapeutic agent is urged into a catheter, or with a second hollow tube and a catheter so that a fluid from the pressure source bypasses the container and enters the catheter.

Abstract: An apparatus includes a housing, a medicament container, and a movable assembly. The movable assembly includes a first movable member and a second movable member. The second movable member is configured to move relative to the first movable member to move the movable assembly from a first configuration to a second configuration. A distal end portion of the second movable member is configured to move a plunger disposed within the medicament container in a distal direction when the movable assembly is moved to the second configuration. The movable assembly is configured to move between a first position and a second position to move the medicament container within the housing between a first container position and a second container position.

Abstract: A method of repairing a defect in an annulus fibrosus of an intervertebral disc, without excising the entire nucleus pulposus of the disc. The method includes inserting an introducer needle through the annulus fibrosus by puncturing the annulus fibrosus with the introducer needle, injecting an in situ curable, bio-compatible polymerizable or polymeric material composition into the disc through the introducer needle directly or indirectly so that the in situ curable composition contacts a defect in the annulus fibrosus; and curing said material in situ.

Abstract: The invention relates to an injection device (1) being in one of a passive and active state, triggering of injection being prevented when said device (1) is in its passive state and permitted when said device (1) is in its active state, having: a housing (30, 30a, 30b) receiving a container, the container being in one of a passive state and an active state, movement of the container out of its initial position being prevented when the container is in its passive state, and being permitted when the container is in its active state, and a safety shield (40) coupled with the housing (30) and being movable with respect to the housing along a movement path having a predetermined length, first retaining means (60, 61, 54a) for maintaining the container (20) in its passive state, second retaining means (34a, 81b) for maintaining said device (1) in its passive state, said device (1) being characterized in that it comprises: first deactivating means (50, 53) and second deactivating means (50, 50a) movable coinciden

Abstract: The present invention relates to a mixing syringe device for delivering a medicament or medical composition to a site of interest. The mixing syringe device generally includes a multi-chambered open lumen and optionally a sectioned plunger. The open lumen has at least two longitudinally oriented chambers within the interior of the lumen, and the optional sectioned plunger has at least two longitudinally oriented extensions corresponding in configuration to the at least two longitudinally oriented chambers of the open lumen and configured to be reciprocatably disposed in the chambers of the open lumen. Each compartment of the lumen is configured to store a medicament component or medical composition component in its interior. In certain embodiments, each compartment is sealed at one end by a movable stopper mechanism and sealed at the other end by a sealing mechanism capable of temporarily or otherwise opening. Methods of use are also provided.

Abstract: A container (2) receives anhydrous material to be hydrated and hydrating fluids. The hydrating fluids are introduced into the container through a fluid port (8) by one or more containers having hydrating fluid. The hydrating fluids may be a mixture of fluids provided in any desired proportion. The hydrated material is then ejected from the container.

Abstract: Thermochemical ablation techniques may provide ablation of bodily tissue using chemical reaction energy.

Abstract: The invention provides for a urinary monitoring device to monitor for the presence or absence of markers indicative of a urinary tract infection (UTI). The invention also provides for methods of using such a device.

Abstract: The invention relates to a syringe-like mixing device, comprising a housing, in which a mixing chamber is formed, a piston, which can be slid in the mixing chamber from the proximal side, and a mixing element, which can be operated from the distal side. In order to ensure simple operation, the mixing device has a sealing cap, which seals the distal open end of the mixing chamber and which has a passage opening, through which an operating rod for the mixing element is guided. The sealing cap can be completely removed from the housing together with the operating rod and the mixing element. In order to discharge the mixing product, a second sealing cap can be placed onto the housing. Accessory parts can be connected to said second sealing cap. The mixing product can then be discharged as with a conventional injection syringe.

Abstract: A computerized electro-mechanical drug delivery device configured to deliver at least one dose of two or more medicaments. The device comprises a control unit. An electro-mechanical drive unit is operably coupled to the control unit and a primary reservoir for a first medicament and a secondary reservoir for a fluid agent, e.g. a second medicament. An operator interface is in communication with the control unit. A single dispense assembly is configured for fluid communication with the primary and the secondary reservoir. Activation of the operator panel sets a first dose from the primary reservoir and based on the first dose and a therapeutic dose profile, the control unit is configured to determine a dose or range of the fluid agent. Alternatively, the control unit determines or calculates a dose or range of a third medicament. Further, a dispense interface for use with a drug delivery device is disclosed.

Abstract: A dermal delivery apparatus includes a pad having a surface to interface with an outer layer of skin. The dermal delivery apparatus also includes a micro structure coupled to the pad and configured to penetrate and deliver an agent beneath the outer layer of skin. The dermal delivery device also includes a base at least partially surrounding the micro structure. The base is coupled to the pad and protrudes away from the surface of the pad to apply surface tension to the skin.

Abstract: An injector (10) for injecting a medicament into a patient. The injector includes a container (18) defining a first chamber (22), which contains a fluid therein, and a second chamber (23). The injector also includes an injection conduit (126) configured for directing the fluid fired from the container into the patient. A transfer mechanism is operable by a user to transfer the fluid from the first chamber to the second chamber in a first stage of operation, and a firing mechanism is operable by the user for firing the fluid from the second chamber through the injection conduit in a second stage of operation. An energy source (62) is in powering association with the firing mechanism to drive firing mechanism in the first and second stages.

Abstract: A method of enabling administration of a drug includes determining, within a drug-transfer device including cells, a location of at least one cell and generating information identifying the determined location. A user may be provided with the drug-transfer device. The drug is retained within the at least one cell when the user is provided with the drug-transfer device. The method also includes encoding a key with the information and providing the user with the key before, after or when the user is provided with the drug-transfer device. Drug retained within the at least one cell is selectively releasable when the key is operably proximate to the drug-transfer device and is encoded with the information. The key can be encoded with the information before and/or after being provided to the user. In some embodiments, the key is encoded based on instructions transmitted over a network.

Abstract: A body portion of the apparatus comprises an interior cavity and a plurality of fluid lumens extending from the cavity to a periphery of the body portion. The apparatus further comprises a first fluid port in fluid communication with a first one of the fluid lumens. The first fluid port is configured to receive a syringe for injecting a liquid diluent and withdrawing a reconstituted liquid medicament. The apparatus further comprises a second fluid port in fluid communication with a second one of the fluid lumens. The second fluid port is configured to receive a medicament vial. The apparatus further comprises a third fluid port at an end of a third one of the fluid lumens for expelling the reconstituted liquid medicament. The apparatus further comprises a stopcock received within the body portion interior cavity and configured to regulate fluid communication between the fluid lumens.

Abstract: A method for mixing and injection and an apparatus for performing the method includes the use of a needle and a needle base, a syringe attachment element and a mixing chamber engagement assembly including a needle chamber surrounding the needle and a first liquid conduit portion, sealed from the needle chamber. A mixing chamber engagement portion includes a second liquid conduit portion communicating with the first liquid conduit portion and a mixing chamber. When the syringe attachment element and the needle base are in a first relative engagement orientation liquid can flow between an interior of the syringe and the first liquid conduit portion and upon axially displacing the needle base and syringe attachment element to a second relative engagement orientation, liquid can flow between an interior of the syringe and the needle.

Abstract: Herein disclosed is a system for applying shear stress ex-situ to a fluid. In some embodiments, the system comprises a shear device; and at least one device configured for intravenous administration of the fluid to a patient, the devices defining a fluid passage configured to be sterilized and maintained sterile during use, the fluid comprising at least one therapeutic fluid, blood, or a combination thereof. The shear device of the system is in fluid communication with the at least one device configured for intravenous administration of the fluid to a patient. Herein also disclosed is a method of preparing a fluid for intravenous administration to a patient.

Abstract: A device for mixing and delivering a mixture of fluids to a target site includes a tube for containing the mixture. A compressible auger for mixing the fluids is movably disposed within the tube, one end of the auger being free at the distal end of the tube. A plunger is also movable within the tube in communication with the other end of the auger. When the plunger is moved axially within the tube the auger also moves axially and the auger is compressed to dispense the fluid. The mixing and delivery device can be used with an apparatus for the arthroscopic delivery of a tissue repair material to a repair site. The apparatus includes a first sheath and a second sheath removably attached to the first sheath for delivering the tissue repair material to the repair site.

Abstract: The invention includes a device having a chamber within a syringe. A fluid passageway extends through a syringe piston. A valve is associated with the passageway controlling fluid passage through the piston. The invention includes a piercing structure having a head segment and a body portion, with a channel through the body portion and through at least one surface of the head without passing through the tip. In another aspect the invention encompasses a method of preparing an agent for administration to an individual. A first component is provided within a syringe and a second component is provided within a vial. A closed valve is associated with a fluid passageway between the vial and the syringe barrel through a piston. Valve repositioning allows fluid passage and sliding of the piston joins the first and second components. Repeated sliding of the piston mixes the components to produce the medication agent.

Abstract: An apparatus for administering a fluid product, including a housing, an administering mechanism accommodated in the housing, an actuation element for actuating the administering mechanism, a receptacle for holding the fluid product, and a lock for releasably locking the actuation element, wherein the receptacle is rotatable relative to the housing and the lock can be moved from a locked position to an unlocked position by rotating the receptacle.

Abstract: Embodiments of a system including a remotely controlled substance delivery device and associated controller are described. Methods of use and control of the device are also disclosed. According to some embodiments, a delivery device or related device may be placed in an environment in order to pump a material into the environment or into an additional fluid handling structure within the device. Exemplary environments include a body of an organism, a body of water, or an enclosed volume of a fluid. The concentration of a substance in the fluid to be delivered may be modified by a remote control signal. In selected embodiments, a magnetic field, an electric field, or electromagnetic control signal may be used.

Abstract: Apparatus and method are disclosed for orally administering to a recipient a medication and a flavor, in a liquid form, for rendering the medication more palatable to the recipient. First and second liquid dispensers are operated manually, independent of one another, either simultaneously or in a selected sequence, and are arranged to advance the medication and the flavor into a conduit for passage through a common outlet to an administering head placed in the recipient's mouth so as to administer the medication and the flavor to the recipient's mouth. The apparatus includes a liquefying device which enables the apparatus to be used for the administration of a medication initially supplied in a non-liquid form.

Abstract: Volume filling and/or augmentation are improved by harvesting live dermis from a donor and processing the dermis for re-injection into the donor. A variety of kits, tools, and methods are described for harvesting, processing, and using injectable dermis in volume filling procedures.