Heart Rate Regulating (e.g., Pacing) Patents (Class 607/9)
  • Patent number: 8410940
    Abstract: A measurement system may comprise a sensor wire and a transceiver unit. The sensor wire may comprise an insertable portion configured to be inserted in a blood vessel of a patient's body and a sensor disposed within the insertable portion at a distal end of the sensor wire. The sensor is configured to measure a parameter when inserted inside the patient. The transceiver unit may comprise: a housing adapted to be connected to a proximal end of the sensor wire; and a first communication module within the housing adapted to wirelessly communicate by a communication signal with an external second communication module in order to transfer information to the external second communication module.
    Type: Grant
    Filed: April 11, 2012
    Date of Patent: April 2, 2013
    Assignee: St. Jude Medical Systems AB
    Inventors: Magnus Samuelsson, Sauli Tulkki
  • Patent number: 8412323
    Abstract: A computer method, employable during an at-rest period of a pacemaker patient, for controlling the operation of the pacemaker so as maximally to support the patient's hemodynamic behavior in a context involving inhibiting fluid overload. The method involves (a) collecting simultaneously occurring ECG and heart-sound information, (b) processing the collected information to obtain at least S3 data, and in certain instances also EMAT and/or % LVST data, (c) utilizing such obtained data, and during the at-rest period, applying (a) pacing rate, (b) pacing intensity, (c) atrio-ventricular delay, and (d) inter-ventricular delay control to the pacemaker.
    Type: Grant
    Filed: January 23, 2009
    Date of Patent: April 2, 2013
    Assignee: Inovise Medical, Inc.
    Inventor: Peter T. Bauer
  • Patent number: 8412347
    Abstract: A charge pump is provided in the same integrated circuit chip as a control means which permits selectively connecting any of one or more electrodes with conductors along a lead. The charge pump derives about two volts from a one-volt supply, and becomes stable within a few tens of microseconds. The charge pump may be composed of three doublers—the first generating timing signals for the second and third doublers, with the second and third doublers working out of phase with each other.
    Type: Grant
    Filed: April 29, 2009
    Date of Patent: April 2, 2013
    Assignee: Proteus Digital Health, Inc.
    Inventor: Mark Zdeblick
  • Publication number: 20130079837
    Abstract: A magnetic switching device includes an electromagnet adapted to be arranged proximate to an exterior surface of an object having a magnetically-switchable device therein and a control circuit electrically connected to the electromagnet. The electromagnet is constructed to generate a magnetic field of sufficient strength and orientation to engage a switch in the magnetically-switchable device. The invention further includes an electrocautery system, including an electrocautery device, a control circuit electrically connected to the electrocautery device, and an electromagnet electrically connected to the control circuit. The electromagnet is adapted to be arranged proximate to an exterior surface of an object having a magnetically-switchable device therein. Operation of the electrocautery device causes the electromagnet to generate a magnetic field of sufficient strength to engage a switch in the magnetically-switchable device.
    Type: Application
    Filed: November 19, 2012
    Publication date: March 28, 2013
    Applicant: Cardiac Lead Technologies, LLC
    Inventor: Cardiac Lead Technologies, LLC
  • Patent number: 8406878
    Abstract: A method for treating patients after a myocardial infarction which includes pacing therapy is disclosed. A cardiac rhythm management device is configured to deliver pre-excitation pacing to one or more sites in proximity to an infarcted region of the ventricular myocardium. Such pacing acts to minimize the remodeling process to which the heart is especially vulnerable immediately after a myocardial infarction.
    Type: Grant
    Filed: October 25, 2011
    Date of Patent: March 26, 2013
    Assignee: Cardiac Pacemakers, Inc.
    Inventors: Qingsheng Zhu, Joseph M. Pastore, Rodney W. Salo
  • Publication number: 20130072997
    Abstract: A method of treating autonomic imbalance in a patient includes energizing a first therapeutic element disposed in a superior vena cava of the patient to deliver therapy to a parasympathetic nerve fiber (e.g. vagus nerve), and energizing a second therapeutic element disposed within the superior vena cava to deliver therapy to a sympathetic cardiac nerve fiber. A neuromodulation system includes a parasympathetic therapy element adapted for positioning within a blood vessel, a sympathetic therapy element adapted for positioning within the blood vessel; and a stimulator to energize the parasympathetic therapy element to deliver parasympathetic therapy to a parasympathetic nerve fiber disposed external to the blood vessel and energize the sympathetic therapy element within the blood vessel to deliver sympathetic therapy to a sympathetic nerve fiber disposed external to the blood vessel. The therapy decreases the patient's heart rate and elevates or maintains the blood pressure of the patient.
    Type: Application
    Filed: July 11, 2012
    Publication date: March 21, 2013
    Inventors: William E. Sanders, Stephen C. Masson, Terrance Ransbury, Richard S. Stack
  • Patent number: 8401645
    Abstract: A method includes selecting an electrode located in a patient; acquiring position information with respect to time for the electrode where the acquiring uses the electrode for repeatedly measuring electrical potentials in an electrical localization field established in the patient; calculating a stability metric for the electrode based on the acquired position information with respect to time; and deciding if the selected electrode, as located in the patient, has a stable location for sensing biological electrical activity, for delivering electrical energy or for sensing biological electrical activity and delivering electrical energy. Position information may be acquired during one or both of intrinsic or paced activation of a heart and respective stability indexes calculated for each activation type.
    Type: Grant
    Filed: September 17, 2009
    Date of Patent: March 19, 2013
    Assignee: Pacesetter, Inc.
    Inventors: Stuart Rosenberg, Thao Thu Nguyen, Kyungmoo Ryu, Kjell Norén, Allen Keel, Wenbo Hou, Michael Yang
  • Patent number: 8401625
    Abstract: In some aspects, a method includes measuring unipolar signals at one or more electrodes in response to electrical activity in a heart cavity. The method also includes determining, based at least in part on Laplace's equation, bipolar physiological information at multiple locations of an surface based on the measured unipolar signals and positions of the one or more electrodes with respect to the surface.
    Type: Grant
    Filed: July 19, 2011
    Date of Patent: March 19, 2013
    Assignee: Rhythmia Medical, Inc.
    Inventors: Doron Harlev, Zsolt Badics
  • Patent number: 8401644
    Abstract: A method and system of post-processing of sensing data generated by a medical device that includes transmitting a plurality of stored sensing data generated by the medical device to an access device, the stored sensing data including sensed atrial events and sensed ventricular events. The access device determines, in response to the transmitted data, instances where the medical device identified a cardiac event being detected in response to the sensing data, and determines whether there is an abrupt onset of the cardiac event in response to the transmitted data.
    Type: Grant
    Filed: November 28, 2006
    Date of Patent: March 19, 2013
    Assignee: Medtronic, Inc.
    Inventors: Bruce D. Gunderson, Mark L. Brown, Amisha Somabhai Patel
  • Patent number: 8401639
    Abstract: Cardiac resynchronization therapy is delivered to a heart using an extended bipolar electrode configuration in accordance with programmed pacing parameters including a non-zero intraventricular delay. The extended bipolar electrode configuration comprises a left ventricular electrode defining a cathode of the extended bipolar electrode configuration and a right ventricular electrode defining an anode of the extended bipolar electrode configuration. A pace pulse is delivered to the left ventricular electrode and anodal stimulation of the right ventricle is detected based on the sensed response to the pace pulse.
    Type: Grant
    Filed: March 16, 2010
    Date of Patent: March 19, 2013
    Assignee: Cardiac Pacemakers, Inc.
    Inventors: Aaron R. McCabe, Shibaji Shome, Yanting Dong, Amy Jean Brisben
  • Patent number: 8401627
    Abstract: Systems and method for assessing a patient's myocardial electrical stability by pacing a patient's heart using a pacing sequence that includes at least two different types of pacing pulses. The pacing rate used is preferably only slightly above the patient's intrinsic heart rate. A degree of alternans, in a signal (e.g., IEGM or ECG) that is indicative of cardiac activity in response to the pacing sequence, is determined. The degree of alternans can be determined by comparing portions of the signal that are indicative of cardiac activity in response to the first type of pacing pulses to portions of the signal that are indicative of cardiac activity in response to the second type of pacing pulses. The patient's myocardial electrical stability is assessed based on the determined degree of alternans.
    Type: Grant
    Filed: August 31, 2007
    Date of Patent: March 19, 2013
    Assignee: Pacesetter, Inc.
    Inventors: Taraneh Ghaffari Farazi, Fujian Qu
  • Patent number: 8401640
    Abstract: According to various method embodiments, a person is indicated for a therapy to treat a cardiovascular disease, and the therapy is delivered to the person to treat the cardiovascular disease. Delivering the therapy includes delivering a vagal stimulation therapy (VST) to a vagus nerve of the person at a therapeutically-effective intensity for the cardiovascular disease that is below an upper boundary at which upper boundary the VST would lower an intrinsic heart rate during the VST.
    Type: Grant
    Filed: April 11, 2012
    Date of Patent: March 19, 2013
    Assignee: Cardiac Pacemakers, Inc.
    Inventors: Weiying Zhao, Quan Ni, Stephen Ruble, Jason J. Hamann
  • Patent number: 8396553
    Abstract: A medical device having a plurality of electrodes sensing cardiac signals, and a microprocessor operably coupled to the plurality of electrodes and configured to determine a cumulative atrioventricular interval (AVI) burden in response to the sensed cardiac signals, and to switch operation of the device between a minimal biventricular pacing (MBVP) mode and a conditional triple chamber pacing (CTCP) mode in response to the determined AVI burden.
    Type: Grant
    Filed: February 26, 2010
    Date of Patent: March 12, 2013
    Assignee: Medtronic, Inc.
    Inventor: Michael O. Sweeney
  • Patent number: 8396552
    Abstract: A pacing system delivers cardiac protection pacing to protect the heart from injuries associated with ischemic events. The pacing system detects an ischemic event and, in response, initiates one or more cardiac protection pacing sequences each including alternative pacing and non-pacing periods. In one embodiment, the pacing system initiates a cardiac protection pacing sequence in response to the detection of the onset of an ischemic event, such that a pacing concurrent conditioning therapy is applied during the detected ischemic event.
    Type: Grant
    Filed: February 2, 2011
    Date of Patent: March 12, 2013
    Assignee: Cardiac Pacemakers, Inc.
    Inventors: Tamara Colette Baynham, Julio C. Spinelli, Frits W. Prinzen, Richard N. Cornelussen, Ward Y. R. Vanagt
  • Patent number: 8396539
    Abstract: An implantable medical device for optically sensing action potential signals in excitable body tissue. The device includes an elongated tubular lead body carrying an optical fiber extending from a proximal lead end to a distal lead end to position the optical fiber at a target site. The lead body additionally carries a conduit for dispensing a voltage-sensitive fluorescent dye into tissue surrounding the target site. The optical fiber transmits excitation light to the fluorescent dye to cause the dye to fluoresce with varying intensity as the transmembrane potentials of local tissue cells vary due to passing depolarization wavefronts. The optical fiber transmits the fluorescence signal to the device to generate an action potential signal or fiducial points of an action potential signal for use in accurately measuring and characterizing electrical activity of excitable tissue.
    Type: Grant
    Filed: February 16, 2007
    Date of Patent: March 12, 2013
    Assignee: Medtronic, Inc.
    Inventors: Vinod Sharma, Xiaohong Zhou
  • Publication number: 20130060297
    Abstract: Techniques are provided for use with implantable medical devices equipped to deliver paired postextrasystolic potentiation (PESP) pacing within a patient having an intact ventricle and a weakened ventricle. A first interpulse interval is determined for use with paired PESP pacing of the intact ventricle sufficient to achieve only relatively minimal potentiation within the intact ventricle. A second interpulse interval is determined for use with paired PESP pacing of the weakened ventricle sufficient to achieve relatively more significant potentiation within the weakened ventricle. Then, paired PESP pacing is delivered to the intact ventricle using the first interpulse interval while paired PESP is also delivered to the weakened ventricle using the second interpulse interval to reduce contractility disequilibrium within the heart caused by the weakened ventricle to achieve a matching of natural contractilities. In this manner, dual ventricular, independently timed, continuous PESP is provided.
    Type: Application
    Filed: September 6, 2011
    Publication date: March 7, 2013
    Applicant: PACESETTER, INC.
    Inventor: Paul M. Stein
  • Patent number: 8391975
    Abstract: A method for use in an implantable medical device system, comprising: selecting a first sensing electrode operatively disposed in a first heart chamber; setting a first sensing window corresponding to cardiac electrical events occurring in a second heart chamber; enabling a first sense amplifier coupled to the first sensing electrode during the first sensing window; sensing a first signal corresponding to cardiac electrical events occurring in the second heart chamber during the first sensing window using the first sensing electrode; and transmitting the first signal from an implantable medical device to an external monitor.
    Type: Grant
    Filed: September 28, 2005
    Date of Patent: March 5, 2013
    Assignee: Medtronic, Inc.
    Inventor: Giorgio Corbucci
  • Patent number: 8391983
    Abstract: Disclosed herein is an implantable pulse generator. The implantable pulse generator may include a header, a can and a feedthru. The header may include a lead connector block electrically coupled to a first conductor. The can may be coupled to the header and include a wall and an electronic component electrically coupled to a second conductor and housed within the wall. The feedthru may be mounted in the wall and include a header side with a first electrically conductive tab and a can side with a second electrically conductive tab electrically coupled to the first tab. The first tab is electrically coupled to the first conductor and the second tab is electrically coupled to the second conductor.
    Type: Grant
    Filed: April 17, 2009
    Date of Patent: March 5, 2013
    Assignee: Pacesetter, Inc.
    Inventor: Wist Lim
  • Patent number: 8391973
    Abstract: An apparatus and method for delivering an external shock pulse receive pacing pulses generated by a first device and a shock pulse generated by a second device. An output of the apparatus is coupled to patient electrodes and the apparatus controls delivery of the received pacing pulses to the output and delivery of the received shock pulse to the output. A control module, pacing control and shock control included in the apparatus cooperatively control delivery of the received shock pulse to the output at a predetermined delay after one of the received pacing pulses.
    Type: Grant
    Filed: January 4, 2008
    Date of Patent: March 5, 2013
    Assignee: Medtronic, Inc.
    Inventors: Vladimir P. Nikolski, William J. Havel, Joseph L. Sullivan, Daniel W. Piraino, Eric R. Williams
  • Patent number: 8386034
    Abstract: Embodiments of the present concept are directed to external defibrillators that include a utility light for use by one or more rescuers using the defibrillator. In one implementation, an external defibrillator has a housing, an energy storage module for storing an electrical charge, a defibrillation port for guiding the stored electrical charge to a person, and a processor for determining when to guide the electrical charge. The defibrillator also includes a user interface that includes a screen showing indications by light, and a separate utility light coupled to the housing via a light-coupling structure. The utility light is structured to generate and cast a beam of light with a beam divergence angle of no more than 160 degrees in order to illuminate a certain point of the local environment. This illumination capability may help rescuers reach a person in need of medical attention and apply medical assistance to the person.
    Type: Grant
    Filed: April 14, 2011
    Date of Patent: February 26, 2013
    Assignee: Physio-Control, Inc.
    Inventors: Mark Frank, Jil Cruz, Micha Coleman, Benjamin A. Flugstad, Fred W. Chapman
  • Patent number: 8386037
    Abstract: A subcutaneous cardiac device includes a subcutaneous electrode and a housing coupled to the subcutaneous electrode by a lead with a lead wire. The subcutaneous electrode is adapted to be implanted in a frontal region of the patient so as to overlap a portion of the patient's heart.
    Type: Grant
    Filed: March 26, 2012
    Date of Patent: February 26, 2013
    Assignee: Cameron Health, Inc.
    Inventors: Alan H. Ostroff, Paul Erlinger, Gust H. Bardy
  • Patent number: 8386036
    Abstract: A medical device programmer and a method of operation in which a first data value is received and used in the execution of one or more algorithms. One or more suggested pulse generator settings are calculated from the one or more algorithms based on the first data value, and the one or more suggested pulse generator settings are displayed on an interactive display screen of the medical device programmer. In one embodiment, the first data value is a duration interval of a QRS complex. From the duration interval, suggestions are made as to one or more ventricular chambers in which to provide pacing pulses. Additionally, pacing intervals for an AV delay are suggested based on measured P-R intervals, or pacing intervals for an LV offset are suggested based on a measured duration interval of a V-V-interval between a right ventricular event and a left ventricular event.
    Type: Grant
    Filed: December 15, 2011
    Date of Patent: February 26, 2013
    Assignee: Cardiac Pacemakers, Inc.
    Inventors: Par Lindh, James Kalgren, Jeffrey E. Stahmann, Rene H. Wentkowski
  • Patent number: 8380307
    Abstract: The invention is directed to a heart stimulator for left-ventricular pacing comprising a left ventricular stimulation pulse generator connected or connectable to a single electrode lead for left ventricular stimulation having one or more electrodes for delivery of stimulation pulses to left ventricular myocardial heart tissue, said stimulation pulse generator being adapted to generate and deliver stimulation pulses of switchable polarity. The heart stimulator further comprises a control unit connected to the stimulation pulse generator for controlling the stimulation pulse generator and to trigger generation and delivery of stimulation pulses having a polarity controlled by said control unit, wherein the control unit is adapted to control said left ventricular stimulation pulse generator so as to deliver at least a pair of suprathreshold stimulation pulses of opposite polarity.
    Type: Grant
    Filed: October 21, 2008
    Date of Patent: February 19, 2013
    Assignee: Biotronik CRM Patent AG
    Inventors: Jie Lian, Garth Garner, Dirk Muessig, Volker Lang
  • Patent number: 8380308
    Abstract: Techniques are provided for use with an implantable cardiac stimulation device equipped with a multi-pole left ventricular (LV) lead having a proximal electrode implanted near an atrioventricular (AV) groove of the heart of the patient. A left atrial (LA) cardioelectrical event is sensed using the proximal electrode of the LV lead and a corresponding LA cardiomechanical event is also detected, either using an implantable sensor or an external detection system. The electromechanical activation delay between the LA cardioelectrical event and the corresponding LA cardiomechanical event is determined and then pacing delays are set based on the electromechanical activation delay for use in controlling pacing. The pacing delays can include, e.g., AV delays for use with biventricular cardiac resynchronization therapy (CRT) pacing. Other techniques described herein are directed to exploiting right atrial (RA) cardioelectrical events detected via an RA lead for the purposes of setting pacing delays.
    Type: Grant
    Filed: March 29, 2011
    Date of Patent: February 19, 2013
    Assignee: Pacesetter, Inc.
    Inventors: Stuart Rosenberg, Kyungmoo Ryu
  • Publication number: 20130041423
    Abstract: Various embodiments of the present invention are directed to systems, methods and devices for cardiac applications including those relating to pacing devices. One such device is directed to a cardiac rhythm therapy (CRT) device designed for dual chamber pacing using two pacing signals each having a positive and negative component that has been modified for single chamber pacing. The device comprises a first output that connects to a pacing lead; a second output that connects to the pacing lead; a third output that connects to a reference point; and electrical circuitry connecting the second electrical connection to the first output, the third electrical connection to the second output, and the first and fourth electrical connections to the third output.
    Type: Application
    Filed: October 12, 2012
    Publication date: February 14, 2013
    Inventors: Qingsheng Zhu, Daniel Felipe Ortega, Julio Cesar Spinelli
  • Patent number: 8369946
    Abstract: An implantable medical device and associated method classify therapy outcomes and heart rhythms in association with therapy outcome. A therapy success time interval is started in response to delivering an arrhythmia therapy. If normal sinus rhythm is detected after the therapy success time interval expires, the delivered therapy is classified as unsuccessful and the detected arrhythmia is classified as a self-terminating rhythm.
    Type: Grant
    Filed: September 16, 2008
    Date of Patent: February 5, 2013
    Assignee: Medtronic, Inc.
    Inventors: Anne M. Gillis, Katherine H. Anderson, Douglas A. Hettrick, David E. Ritscher
  • Patent number: 8369949
    Abstract: A system and method for recording sensing and pacing events in a cardiac rhythm management device. The method may be particularly useful in assessment of pacing parameters for ventricular resynchronization therapy.
    Type: Grant
    Filed: March 15, 2010
    Date of Patent: February 5, 2013
    Assignee: Cardiac Pacemakers, Inc.
    Inventors: Jeffrey E. Stahmann, Rene H. Wentkowski, Andrew P. Kramer, James Kalgren
  • Patent number: 8369943
    Abstract: An implantable neural stimulation system includes an implantable medical device having a neural stimulation circuit and at least one implantable lead configured to allow one or more stimulation electrodes to be placed in one or more lymphatic vessels of a patient, such as the patient's thoracic duct and/or vessels branching from the thoracic duct. Neural stimulation pulses are delivered from the implantable medical device to one or more target regions adjacent to the thoracic duct or the vessels branching from the thoracic duct through the one or more stimulation electrodes.
    Type: Grant
    Filed: October 22, 2009
    Date of Patent: February 5, 2013
    Assignee: Cardiac Pacemakers, Inc.
    Inventors: Allan C. Shuros, Randy Westlund, Anthony V. Caparso
  • Patent number: 8369948
    Abstract: An apparatus for reversing ventricular remodeling with electro-stimulatory therapy. A ventricle is paced by delivering one or more stimulatory pulses in a manner such that a stressed region of the myocardium is pre-excited relative to other regions in order to subject the stressed region to a lessened preload and afterload during systole. The unloading of the stressed myocardium over time effects reversal of undesirable ventricular remodeling.
    Type: Grant
    Filed: October 24, 2011
    Date of Patent: February 5, 2013
    Assignee: Cardiac Pacemakers, Inc.
    Inventors: Andrew P. Kramer, Rodney W. Salo, Julio C. Spinelli, Bruce H. KenKnight
  • Patent number: 8369947
    Abstract: To provide a nerve stimulation device capable of stimulating a vagus nerve stably while reducing the risk of interrupting a treatment by nerve stimulation due to disconnection or the like. Adopted is a nerve stimulation device including a first electrode and a second electrode disposed in different positions on the vagus nerve, a pulse generating part connected to each of these electrodes, for outputting an electric pulse for stimulating the vagus nerve, and a setting part for switching the electrode to which the electric pulse from the pulse generating part is transmitted.
    Type: Grant
    Filed: September 20, 2010
    Date of Patent: February 5, 2013
    Assignee: Olympus Corporation
    Inventor: Takeo Usui
  • Publication number: 20130030494
    Abstract: Devices, systems, and methods are disclosed for relaying information from a cardiac pacemaker to an external device. Logic on the pacemaker modulates a heartbeat clock of the pacemaker to encode information onto a blood pressure sequence. This is accomplished by adding or subtracting a small subinterval to or from a pulse repetition interval of the pacemaker. A muscle stimulator beats the heart according to the modulated sequence. A monitoring device external to the body monitors the blood pressure to retrieve the encoded information, or message. The encoded information is then decoded to determine the information in the message. This information may concern the pacemaker as well as other devices within the body that are in communication with the pacemaker such as blood monitors, etc. Since the message is conveyed via simple modulation of the heart beat intervals, no separate transmitter is required in the pacemaker which would otherwise increase cost and decrease battery life.
    Type: Application
    Filed: July 27, 2011
    Publication date: January 31, 2013
    Applicant: AT&T MOBILITY II LLC
    Inventors: Sheldon Kent Meredith, Brandon Bowers Hilliard, Mario B. Kosseifi
  • Patent number: 8364261
    Abstract: A pacing monitoring system is described for incorporation in an implantable pacemaker that monitors the pacing rate and/or cumulative pace count in order to protect a patient from excessive pacing. The system includes monitoring circuitry that is configured to operate in multiple monitoring zones, where each zone is adapted to prevent excessively high-rate pacing during a particular mode of device operation.
    Type: Grant
    Filed: November 1, 2010
    Date of Patent: January 29, 2013
    Assignee: Cardiac Pacemakers, Inc.
    Inventors: Scott Stubbs, Conrad L. Sowder, William J. Linder, Lynn S. Elliott, Kenneth P. Hoyme, Hiten J. Doshi
  • Patent number: 8364260
    Abstract: An external defibrillator having a battery; a capacitor electrically communicable with the battery; at least two electrodes electrically communicable with the capacitor and with the skin of a patient; a controller configured to charge the capacitor from the battery and to discharge the capacitor through the electrodes; and a support supporting the battery, capacitor, electrodes and controller in a deployment configuration, the defibrillator having a maximum weight per unit area in the deployment configuration of 0.1 lb/in2 and/or a maximum thickness of 1 inch. The support may be a waterproof housing.
    Type: Grant
    Filed: August 5, 2011
    Date of Patent: January 29, 2013
    Assignee: Kuman and Rao Family Trust
    Inventor: Uday N. Kumar
  • Patent number: 8359096
    Abstract: An active implantable medical device for cardiac resynchronization with automatic and almost in real time optimization of the interventricular and atrio-ventricular delays is disclosed. The active implantable medical device includes a closed-loop for continuously controlling the atrio-ventricular delay AVD and the inter-ventricular delay VVD according to a hemodynamic signal delivered by a hemodynamic sensor. The closed-loop provides controlled modulation (38) and demodulation (42) the AVD, and modulation (48) and demodulation (52) the VVD, the modulation and demodulation being functionally interdependent (54, 56) by a sequence of alternating operation. A closed-loop regulator (36) for controlling the AVD receives as input an error signal (EAVD) delivered based on demodulating the AVD (42) and outputs an AVD signal. A closed-loop regulator (46) for controlling the VVD receives as input a signal error (EVVD) based on demodulating the DVV and outputs a VVD signal.
    Type: Grant
    Filed: February 9, 2011
    Date of Patent: January 22, 2013
    Assignee: Sorin CRM S.A.S.
    Inventor: Alaa Makdissi
  • Patent number: 8355781
    Abstract: An implantable heart stimulator (10), which has a right-atrial sensing unit (62), which is connected or is to be connected to a right-atrial electrode for recording electrical potentials of the myocardium of a right atrium, and is implemented to process electrical signals recorded via the right-atrial electrode, and to detect signal features characterizing a right-atrial stimulation and contraction in the electrical signal recorded via the right-atrial electrode. The heart stimulator (10) additionally has a left-ventricular sensing unit (66), which is connected or is to be connected to a left-ventricular electrode for recording electrical potentials of the myocardium of a left ventricle of a heart and is implemented to process electrical signals recorded via the left-ventricular electrode. The left-ventricular sensing unit (66) is implemented to detect signal features in the electrical signal recorded via the left-ventricular electrode which characterize a left-atrial contraction.
    Type: Grant
    Filed: November 16, 2008
    Date of Patent: January 15, 2013
    Assignee: Biotronik CRM Patent AG
    Inventors: Bruno Ismer, Thomas Koerber, Wolfgang Voss, Georg Heinrich von Knorre, Bjoern Riedel, Andreas Neumann, Ulrich Busch, Juergen Pilz, Thomas Brueggemann, Ralf Peters
  • Patent number: 8355782
    Abstract: Implantable heart stimulator connectable to an electrode arrangement has a pulse generator adapted to deliver stimulation pulses to a heart of a subject; an impedance measurement unit adapted monitor at least one heart chamber of the heart of the subject to measure the impedance in the at least one monitored heart chamber for generating an impedance signal corresponding to the measured impedance. The impedance signal is applied to a processor where the signal is processed, according to specified criteria, and a fractionation index value is determined represented by the curve length of the impedance signal during a predetermined measurement period. The fractionation index value is a measure of different degrees of mechanical dyssynchrony of the heart.
    Type: Grant
    Filed: January 28, 2008
    Date of Patent: January 15, 2013
    Assignee: St. Jude Medical AB
    Inventors: Andreas Blomqvist, Nils Holmström, Malin Öhlander, Sven-Erik Hedberg
  • Patent number: 8352027
    Abstract: A cardiac rhythm management system for providing a plurality of therapy modalities. For example, the system may include a cardiac resynchronization therapy module for providing cardiac resynchronization therapy and a pacemaker module for providing bradycardia therapy, as well as a selector module coupled to the cardiac resynchronization therapy module and the bradycardia module. The selector module may select an operating mode from among a plurality of operating modes including the cardiac resynchronization therapy module and the pacemaker module. Various manual and automatic methods may be used to select the operating mode. In addition, a reversion management system may be included to assist the cardiac rhythm management system to recover in case of a disruption to the system.
    Type: Grant
    Filed: March 13, 2008
    Date of Patent: January 8, 2013
    Assignee: Cardiac Pacemakers, Inc.
    Inventors: Julio Spinelli, Qingsheng Zhu, Bruce H. Kenknight, Yinghong Yu, Jiang Ding
  • Patent number: 8352028
    Abstract: An implantable medical device system, including an implantable medical device and an associated implant tool. The device has a hermetic housing containing a power source and electronic circuitry. One or more tines are mounted to the housing movable from a first position extending away from the housing to a second position adjacent the housing. The device is provided with a rotational fixation mechanism. The Implant tool includes an elongated sheath sized to receive the device and provided with internal grooves sized to engage with the tines when the tines are located in their second position. The implant tool may further include a push tool located with the sheath and movable within the sheath to advance the device distally out of the sheath. The sheath may be provided with a closed distal end openable by passage of the device therethrough.
    Type: Grant
    Filed: April 26, 2010
    Date of Patent: January 8, 2013
    Assignee: Medtronic, Inc.
    Inventor: William K Wenger
  • Patent number: 8352029
    Abstract: A method for implementing a neural stimulation therapy mode in an implantable medical device (IMD) comprising the acts of mapping respective device states, defined by one or more timer states that include at least one neural event timer or one or more indications of one or more sensed physiologic events, to associated device actions in a stored neural table, storing an event represented as a device status word and a time stamp in a queue in response to an action input, and comparing one or more current timer states or one or more indications of one or more sensed physiologic events to a device state contained in the neural table and, if found to match, causing performance of one or more associated device actions, wherein the device actions include one or more of a neural stimulation energy delivery or a change in one or more timer states.
    Type: Grant
    Filed: May 24, 2010
    Date of Patent: January 8, 2013
    Assignee: Cardiac Pacemakers, Inc.
    Inventors: David J. Ternes, Doug M. Birkholz, David W. Yost, James A. Esler
  • Patent number: 8352025
    Abstract: A leadless cardiac pacemaker configured for implantation in electrical contact with a left ventricular cardiac chamber and configured for leadless triggered left-ventricular pacing for cardiac resynchronization therapy (CRT) in response to conducted signals from a pulse generator.
    Type: Grant
    Filed: October 13, 2006
    Date of Patent: January 8, 2013
    Assignee: Nanostim, Inc.
    Inventor: Peter M. Jacobson
  • Patent number: 8346359
    Abstract: Techniques are provided for use by implantable medical devices for controlling ventricular pacing, particularly during atrial fibrillation. In one example, during a V sense test for use in optimizing ventricular pacing, the implantable device determines relative degrees of variation within antecedent and succedent intervals detected between ventricular events sensed on left ventricular (LV) and right ventricular (RV) sensing channels. Preferred or optimal ventricular pacing delays are then determined, in part, based on a comparison of the relative degrees of variation obtained during the V sense test. In another example, during RV and LV pace tests, the device distinguishes QRS complexes arising due to interventricular conduction from QRS complexes arising due to atrioventricular conduction from the atria, so as to permit the determination of correct paced interventricular conduction delays for the patient. The paced interventricular conduction delays are also used to optimize ventricular pacing.
    Type: Grant
    Filed: July 22, 2009
    Date of Patent: January 1, 2013
    Assignee: Pacesetter, Inc.
    Inventor: Xiaoyi Min
  • Patent number: 8346360
    Abstract: Various system embodiments comprise a stimulator adapted to deliver a stimulation signal for a heart failure therapy, a number of sensors adapted to provide at least a first measurement of a heart failure status and a second measurement of the heart failure status, and a controller. The controller is connected to the stimulator and to the number of sensors. The controller is adapted to use the first and second measurements to create a heart failure status index, and control the stimulator to modulate the signal using the index. Other aspects and embodiments are provided herein.
    Type: Grant
    Filed: August 22, 2011
    Date of Patent: January 1, 2013
    Assignee: Cardiac Pacemakers, Inc.
    Inventors: Imad Libbus, Krzysztof Z. Siejko, Marina V. Brockway, Robert J. Sweeney
  • Patent number: 8346358
    Abstract: A pacemaker is disclosed which reestablishes or keeps the physiological electric conduction of the heart and a method of application. The pacemaker is a pulse generator, it has a ventricular output including at least two superimposed monopolar pulsewaves of reversed polarity between each other, with programmable configuration, with respect to a neutral which can be the pacemaker's metallic box or a third electrode in the case of a tripolar catheter. The catheter can have a deflectable sheath, with an electrode on its distal tip. The invention consists of a new pacemaker, and a method of application in the right ventricular septum, being able to use in order to facilitate the implantation and to avoid the connection and the disconnection, a sheath to check a proper place and then screw the catheter in said place.
    Type: Grant
    Filed: December 13, 2005
    Date of Patent: January 1, 2013
    Assignee: Cardiac Pacemakers, Inc.
    Inventors: Daniel Felipe Ortega, Alberto German Giniger
  • Patent number: 8340762
    Abstract: The invention is directed to tri-phasic pulse generation techniques that make use of a pre-stimulus phase, a stimulus phase, and a post-stimulus phase in a pulse generation cycle. During the pre-stimulus phase, an output capacitor is charged to a desired voltage level. During the stimulus phase, the capacitor is discharged, and during the post-stimulus phase recharging of the capacitor begins again. In accordance with the invention, charging of the output capacitor can be terminated during the post-stimulus phase after a measured voltage in the patient is greater than or equal to a threshold.
    Type: Grant
    Filed: April 23, 2003
    Date of Patent: December 25, 2012
    Assignee: Medtronic, Inc.
    Inventors: Ben F. M. Vonk, Willem J. A. Esmeijer, Harry B. A. Kerver
  • Patent number: 8340764
    Abstract: A pacing system delivers cardiac protection pacing to protect the heart from injuries associated with ischemic events. The pacing system detects an ischemic event and, in response, initiates one or more cardiac protection pacing sequences each including alternative pacing and non-pacing periods. In one embodiment, the pacing system initiates cardiac protection pacing sequences including at least one postconditioning sequence to protect the heart from a detected ischemic event and a plurality prophylactic preconditioning sequences to protect the heart from probable future ischemic events.
    Type: Grant
    Filed: February 17, 2011
    Date of Patent: December 25, 2012
    Assignee: Cardiac Pacemakers, Inc.
    Inventors: Tamara Colette Baynham, Yi Zhang, Joseph M. Pastore
  • Patent number: 8340763
    Abstract: A method and apparatus for treatment of hypertension and heart failure by increasing secretion of endogenous atrial hormones by pacing of the heart atria. Atrial pacing is done during the ventricular refractory period resulting in premature atrial contraction that does not result in ventricular contraction. Pacing results in the atrial wall stress, peripheral vasodilation, ANP secretion. Concomitant reduction of the heart rate is monitored and controlled as needed with backup pacing.
    Type: Grant
    Filed: September 8, 2009
    Date of Patent: December 25, 2012
    Assignee: BackBeat Medical, Inc.
    Inventors: Howard Levin, Mark Gelfand
  • Patent number: 8340766
    Abstract: A method of identifying potential driver sites for cardiac arrhythmias includes acquiring a plurality of electrograms from a plurality of locations on at least a portion of a patient's heart. Using the acquired electrograms, at least one electrical activity map is generated. Desirable electrical activity maps include complex fractionated electrogram standard deviation and mean maps, dominant frequency maps, peak-to-peak voltage maps, and activation sequence maps. Using one or more of these maps (e.g., by analyzing one or more electrogram morphological characteristics represented by these maps), at least one potential driver site can be detected.
    Type: Grant
    Filed: October 7, 2010
    Date of Patent: December 25, 2012
    Assignee: St. Jude Medical, Atrial Fibrillation Division, Inc.
    Inventors: Kyungmoo Ryu, Valtino X. Afonso
  • Patent number: 8340761
    Abstract: Methods and devices for treating a blockage in the coronary arterial system are provided. Some blockages in the coronary arterial system restrict the blood flow to a portion of the heart, causing ischemia or infarction. Such blockages may be treated by displacing, removing and/or breaking up the blockage, which allows blood to reperfuse into the infarcted portion of the heart. Before, during, and/or after the reperfusion, cardioprotective pacing is provided to the heart. The devices have multiple electrodes in order to provide multiple locations at which the cardioprotective pacing may be delivered. The devices are adapted to deliver cardioprotective pacing to the heart via the electrode that results in a relatively high level of dyssynchrony of the heart.
    Type: Grant
    Filed: June 3, 2010
    Date of Patent: December 25, 2012
    Assignee: Cardiac Pacemakers, Inc.
    Inventors: Eric A. Mokelke, Allan C. Shuros, James A. Esler
  • Patent number: 8335563
    Abstract: An implantable medical device with an inductive switching regulator having an inductor with a ferromagnetic core is described. The device incorporates a core saturation detector for detecting saturation in the inductor core indicating the presence of a magnetic field such as produced by an MRI scan. The device is configured to alter its behavior when core saturation is detected such as by entering an MRI mode that may include cessation of therapy, fixed-rate bradycardia pacing, and/or disablement of tachyarrhythmia therapy.
    Type: Grant
    Filed: March 24, 2009
    Date of Patent: December 18, 2012
    Assignee: Cardiac Pacemakers, Inc.
    Inventor: Nicholas J. Stessman
  • Patent number: 8335565
    Abstract: Methods and systems involve adjusting an energy used for safety pacing based on the capture threshold. The safety pacing energy may be adjusted prior to a capture threshold test. During the capture threshold test, backup safety paces are delivered using the adjusted pacing energy. Following suspension of automatic capture verification, the device may enter a suspension mode. During the suspension mode, safety pacing pulses are delivered using a pacing energy adjusted based on capture threshold.
    Type: Grant
    Filed: October 12, 2010
    Date of Patent: December 18, 2012
    Assignee: Cardiac Pacemakers, Inc.
    Inventors: Scott M. Freeberg, Michael J. Lyden, Qingsheng Zhu