Abstract: An automatic medication injection device (20) including injecting progress indicators (82-85) visible along a periphery of the device housing (23). The injecting progress indicators include a flag element (100) which is movable as a drive mechanism (60) of the device advances a sealing plunger (58) within a container of medication (50). The injecting progress indicators are configured to indicate sequentially during a single injection as the flag element moves to cooperatively complete different injecting progress indicators at different times during the single injection, whereby injecting progress of the injection may be monitored by a user.

Abstract: A drive assembly for a drug delivery device includes a housing; a number sleeve threadedly engaged with the housing; a dial link rotatably fixed with the number sleeve in a first axial arrangement relative to each other, the number sleeve being rotatable relative to the dial link in a second axial arrangement; a clutch component connected to an inner proximal section of the number sleeve through multiple flexible assembly fingers. The clutch component can engage the number sleeve with the dial link in the first axial arrangement and disengage the number sleeve from the dial link in the second axial arrangement. The drive assembly includes means for preventing an access to the flexible assembly fingers from the outer proximal section of the number sleeve and/or the flexible assembly fingers from flexing inwardly and disengaging from the connection with the inner proximal section.

Abstract: The present invention relates to ready to dilute injectable formulations of bortezomib comprising bortezomib, non-aqueous solvents enhancing the solubility and pH modifying agent.

Abstract: A syringe assembly including a plunger rod having a first end, a second end, and a rod portion extending therebetween, wherein at least a portion of the rod portion is flexible is disclosed. The flexible portion of the rod portion allows a stopper to be moved between a first position and a second position within a syringe barrel while the overall length of the syringe assembly remains the same throughout the movement between the first position and the second position. In another embodiment, a syringe assembly including a restraining member adapted to communicate with the flexible portion of the rod portion such that movement of the first end of the plunger rod in a first direction actuates movement of the second end of the plunger rod in a second direction different than the first direction is disclosed.

Abstract: A drug delivery device is provided with a cartridge holder having at least one guide track, and a body having at least one interaction member adapted and arranged to mechanically cooperate with the at least one guide track. The guide track has a first section and a second section, wherein the path which is defined by the first section encloses an angle with the longitudinal axis of the device, wherein the angle which is enclosed by the path defined by the first section with the longitudinal axis is smaller than the angle which is enclosed by the path defined by the second section with the longitudinal axis.

Abstract: A packaging apparatus is provided for holding a sterile product. In one aspect, a secondary packaging holder is configured with a base and a receiving portion to receive and irreversibly hold a primary packaging holder. The secondary packaging holder can have a substantially planar wall configured to affix an identifying label thereto. The secondary packaging holder can be configured to snap fit to a neck of the primary packaging holder to hold the primary packaging holder such that a portion of the primary packaging holder is exposed outside of the secondary packaging holder based on a height relationship between the secondary packaging holder and the primary packaging holder.

Abstract: An auto-injector for administering a dose of a liquid medicament includes an elongate housing arranged to contain a syringe with a hollow needle and a stopper for sealing the syringe and displacing the medicament, the housing having a distal end and a proximal end with an orifice intended to be applied against an injection site. The syringe is slidably arranged with respect to the housing. A spring capable of, upon activation: pushing the needle from a covered position inside the housing into an advanced position through the orifice and past the proximal end, operating the syringe to supply the dose of medicament, and retracting the syringe with the needle into the covered position. After delivering the medicament, an activator arranged to lock the spring in a pressurized state prior to manual operation and capable of, upon manual operation, releasing the spring for injection.

Abstract: A closed male luer includes a first connector having an upper end portion defining an axial recess, an inner circumferential slide track and several first ratchet teeth; and a second connector having lower end portion received in the axial recess of the first connector, having several second ratchet teeth selectively meshed with the first ratchet teeth such that rotation of the first connector in a first direction drives the second connector to rotate simultaneously in the first direction, wherein, after an upper end portion of the second connector is connected with a second member, rotation of the first connector in the first direction or rotation of the second connector in a second direction opposite to the first direction can break up the second ratchet teeth into pieces by the first ratchet teeth, hence permitting the second connector to rotate freely in 360° relative to the first connector.

Abstract: The present invention relates to a medicament delivery device comprising a housing having opposite distal and proximal ends; a medicament container holder with a medicament container, disposed within the housing, wherein the container has a front opening with or for a delivery member for delivering the medicament therethrough and at least a movable stopper; a drive unit comprising a power source and a plunger rod, wherein said drive unit is arranged to be movable between a non-delivery state in which said power source is in a cocked state and a delivery state in which said power source acts on said plunger rod which in its turn acts on said stopper for delivering a dose of medicament from said medicament container; retaining means operably connected to said drive unit, and capable of holding said drive unit in its non-delivery state; and activation means operably connected to said retaining means, and capable of releasing said drive unit from its non-delivery state; wherein the device further comprises a deli

Abstract: Provided herein are boronic acid esters of boronic acid therapeutic agents, such as bortezomib. The boronic acid esters can be used to prepare liposomal formulations of boronic acid therapeutic agents with improved properties, such as enhanced stability. This disclosure, in one aspect, relates to compositions and methods of making and using the compositions.

Abstract: An attachment for a syringe or carpule includes a main body that encloses an interior space, into which a protrusion of the syringe or carpule can be inserted. The main body has a jacket surrounding the interior space, and includes an inner body connected to the jacket and arranged coaxially thereto. The inner body has an inner wall that, in the attached state of the attachment, contacts an outer surface of the protrusion or of the syringe or carpule by means of an interior surface facing the interior space. The inner wall of the inner body is connected to the jacket of the attachment by a number of webs. At least one web encloses an angle together with an imaginary radially extending line, the angle being greater than 0° and acute.

Abstract: The present invention is directed to a housing for a drug delivery device. The housing comprises an outer shell with an aperture, an insert received within the aperture and a clamp attached to the outer shell. The insert has at least one recess which is engaged by a lug of the clamp to retain the insert within the aperture of the outer shell. The invention is further directed to a pen-type injector having such a housing.

Abstract: A system for use in combining two part preparations, such as bone cement, can include a chamber for intermixing liquid and powder components, a container, a vacuum channel, and a filter. The mixing chamber can be configured to hold a non-liquid, polymer powder component of a bone cement. The container can be configured to hold a liquid component of the bone cement. The vacuum channel can direct a partial vacuum to draw the liquid component from the container into the non-liquid component in the mixing chamber to intermix the components and to thereby provide a settable bone cement.

Abstract: An auto-injector device for administering a liquid pharmaceutical composition, in which an end-user can select between doses that the device is capable of delivering. The end-user choices that translate into the selected doses can be based on end-user perceived severity of symptoms, end-user weight and other such factors. In some embodiments the auto-injector is configured to administer the one chosen dose only. In other embodiments, the auto-injector can deliver second and subsequent doses up to full dose of the pharmaceutical composition disposed in the injector. The auto-injector can provide visual, audio, and tactile feedback, alone or in combination, to the user to indicate the dose selected, instructions for use, and when the dose has been administered.

Abstract: A medication injecting apparatus has a cartridge housing and a drive housing that is threadedly connected to the cartridge housing for axial displacement relative to one another. The drive housing has a helical-shaped passage and a flexible drive member is slidingly disposed within the helical-shaped passage and extends axially outwardly therefrom toward the cartridge housing. The flexible drive member is movable in the axial direction relative to the drive housing during dose setting and is axially fixed relative to the drive housing during injecting. A clutch has an engaged position and a disengaged position. The flexible drive member is axially fixed relative to the drive housing when the clutch is in the engaged position and the flexible drive member is movable relative to the drive housing when the clutch is in the disengaged position.

Abstract: The invention relates to an arrangement for detecting a position of a plunger relative to a bung in a drug cartridge, comprising a proximity sensor located close to a distal end of the plunger facing the bung and aligned to receive light reflected by the bung.

Abstract: The present invention relates to a medicament delivery device (100) having a a drive mechanism arranged to drive a plunger rod (12). A last dose limiting mechanism is arranged to interact with the drive mechanism and limit the distal end position of an actuator (3) when the plunger rod (12) has reached a pre-determined position between its distal end position and its proximal end position.

Abstract: The present disclosure provides a modular, connectable, dual chamber syringe system that can be used to mix, dispense and/or inject multiple materials sequentially or concurrently. The dual chamber syringe system may be prefilled in advance with different materials, e.g., multiple medicaments, and prepackaged, and is capable of being removed from the packaging and being used immediately, such as in a medical setting. In one illustrative embodiment, the dual chamber syringe system includes a design with the following arrangement of the main components: hypodermic needle—first container with female threaded end—male threaded cap—female threaded cap—second container with male threaded end—plunger. In a second illustrative embodiment, the dual chamber syringe system includes a design with the following arrangement of the main components: hypodermic needle—first container with female threaded end—membrane—membrane—second container with male threaded end—plunger.

Abstract: A dispensing device which disperses medicate through a needle across a zone within a body. The device includes a needle which is, during use, becomes encapsulated within a tubular needle-receiving member, a reservoir in fluid communication with the needle, positioned within the housing, and in communication with the needle, a second reservoir, a reservoir-connecting conduit in communication with the reservoir, a fluid drive in communication with the fluid in the second reservoir and in communication with the reservoir-connecting conduit, and a linear drive attached to the needle or to the needle-receiving member. The fluid drive impel fluids from the second reservoir to the reservoir-connecting conduit and thus drives the therapeutic agent from the reservoir during the linear displacement of the needle towards the housing. Fluid communication from the therapeutic agent reservoir to the needle is maintained by the tubing during operation of the linear drive.

Abstract: A drive mechanism for a medication delivery device is presented having a housing, a rotation member that rotates in a first direction with respect to the housing during setting of a dose of a medication and rotates in a second direction with respect to the housing during delivery of the dose, the second direction being opposite to the first direction. The device also has a piston rod that is displaced in a distal direction with respect to the housing for delivering the dose, a drive member which follows rotational movement of the rotation member in the second direction during delivery of the dose, and a stop member which prevents rotational movement of the drive member with respect to the housing in the first direction during setting of the dose.

Abstract: A nebulizer (1) comprises one or more removable components (5,7,9,13), for example a mesh assembly (9), mouthpiece, plunger assembly (7) and medication chamber (13), each having an associated data carrier (5a, 7a, 9a). The data carrier (5a, 7a, 9a) can be used to store information indicating the type of removable component (5,7,9,13) that is fitted to the nebulizer (1). A removable component (5,7,9,13) may be from a set of such removable components. For example, a mouthpiece (5) fitted to the nebulizer (1) may be from a set of mouthpieces having different flow rates. The data carrier (5a, 7a, 9a) may also be used to control operation of the nebulizer (1). A data carrier (9a) attached to a mesh (9) may be used to prevent the nebulizer (1) from being used when the mesh (9) has been used a predetermined number of times.

Abstract: An injection device for delivering a predetermined fixed dose of liquid drug, comprising a base member, a piston rod a first tubular member, and a second tubular member.

Abstract: According to the invention, a safety device for a pre-filled syringe comprises a hollow support body to retain the pre-filled syringe therein, a hollow needle shield that is slidable relative to the support body and guiding means for guiding the movement of the needle shield relative to the support body. The guiding means comprise a guide pin, a guide track and a cut-out adjacent to the guide track. The guide pin protrudes into the guide track and moves within and along the guide track when the needle shield is slid relative to the support body. The cut-out allows a side wall of the guide track to be deflected in a lateral direction perpendicular to a central axis of the safety device.

Abstract: A system for optimizing a patient's basal insulin dosage regimen over time, adapted to determine from blood glucose values whether and by how much to vary a patient's present recommended amount of the insulin-containing drug in order to maintain the patient's future blood glucose level measurements within a predefined range, and wherein a given blood glucose value is disregarded if no patient-actuated operation being indicative of the administration of a dose of an insulin containing drug has been detected in a pre-defined amount of time prior to the determination of the given blood glucose value.

Abstract: The invention relates to a method and a device for treatment of glaucoma, wherein by means of an elongated catheter provided with a distal portion and a proximal portion, a tube-shaped implant is inserted and released in a Schlemm's canal with two opposite openings exposed by an incision and a folded up scleral flap. In a first phase, the distal portion inserted into the Schlemm's canal through the first opening, while a fluid or gaseous medium is injected at the same time, and exited through the second opening, which is, in circumferential direction, oppositely located. The implant detachably disposed at the protruding distal portion and, in a second phase, inserted, in circumferential direction, into the expanded Schlemm's canal up to the first opening. Subsequently, the distal portion, which protrudes from the first opening, is detached from the implant and, together with the catheter, removed.

Abstract: Described herein are pharmaceutical packaging systems which prevent oxidative degradation of oxygen-sensitive drugs, such systems including a primary packaging container with an oxygen permeable component, a secondary packaging with very low permeability to oxygen and an oxygen absorber.

Abstract: The present invention relates to an automatic injection device (1) comprising: a container having a longitudinal axis A and movable between a first position and a second position, in which the needle is inserted, biasing means, for moving the container to its second position, retaining means (70, 73, 74) for maintaining said biasing means in a first stressed state, triggering means (90) for releasing said retaining means, said retaining means comprising a lever member having a pivoting part and a radial projection extending therefrom, said radial projection being in a first angular position when said retaining means is in its passive condition, said radial projection being in a second angular position, different from said first angular position, when said retaining means is in its active condition, the axis of said pivoting part being included in a transversal plane of said longitudinal axis A.

Abstract: Provided is an apparatus and method for measuring a dose in an injector, which is capable of measuring a dose without modifying the mechanical structure of the injector. A number sleeve is provided to pass through an injector body and is connected to be spirally movable, and a pattern for dose measurement is formed on an outer periphery of the number sleeve. The injector body includes a sensor for sensing the pattern formed on the number sleeve when the number sleeve performs a spiral movement, and a controller for measuring a dose according to a spiral movement distance of the number sleeve through the sensor.

Abstract: The present invention relates to an automatic injection device (1) comprising: a container (2) having a longitudinal axis A and movable between a first position and a second position, in which the needle is inserted, biasing means (8), for moving the container to its second position, retaining means (70, 74, 74b) for maintaining said biasing means in a first stressed state, triggering means (90, 91e) for releasing said retaining means, said retaining means comprising a lever member having a rotatable cylinder part and a radial projection extending therefrom, said radial projection being in a first angular position when said retaining means is in its passive condition, said radial projection being in a second angular position, different from said first angular position, when said retaining means is in its active condition, said rotatable cylinder part being included in a transversal plane of said longitudinal axis A.

Abstract: An injection device includes a housing, a receptacle for receiving a medicine cartridge and configured for attachment to a proximal end of the housing, and a leadscrew having an end for engaging with a bung of a cartridge. The leadscrew has a first thread extending axially along an outer surface thereof and at least one axially extending guide track. The injection device includes a rotatable drive mechanism for engaging with the first thread or guide track, and a guiding element for engaging with the other of the first thread or guide track, the guiding element being non-rotatable with respect to the housing during an injection operation, whereby rotation of the drive mechanism causes the leadscrew to move axially in a proximal direction in order to deliver a dose from the cartridge. The injection device further includes a stop member located proximal to the rotatable drive mechanism and the guiding element.

Abstract: Provided is a delivery device that has an initial locked position, an intermediate priming position, and a final delivery position. The device is configured such that individual dose setting and activation of delivery is prevented until a cap is removed.

Abstract: A pre-filled syringe assembly having a tamper evident tip cap is provided for indicating if the contents of the syringe assembly have been compromised. The syringe barrel has an interior chamber which defines a pressure therein and is sealed at the proximal and distal ends by a first and second seal, respectively, to maintain this pressure. The second seal is formed of a deformable material and a tip cap is located about the second seal and distal end of the syringe barrel. This tip cap includes a viewable indicator representing a change in state of the syringe contents. The indicator has a portion positioned in contact with the second seal such that the first distinguishing feature is viewable through a portion of the cap. Tampering of the contents within the interior chamber causes a change in pressure and movement of the indicator indicating tampering of the syringe assembly.

Abstract: The techniques and arrangements described herein provide for layered compression of depth image data. In some examples, an encoder may partition depth image data into a most significant bit (MSB) layer and a least significant bit (LSB) layer. The encoder may quantize the MSB layer and generate quantization difference data based at least in part on the quantization of the MSB layer. The encoder may apply the quantization difference data to the LSB layer to generate an adjusted LSB layer.

Abstract: Adjustable volume syringes and systems are disclosed. An adjustable volume syringe includes a delivery syringe barrel, a reservoir syringe barrel positioned at least partially within the delivery syringe barrel, and a reservoir plunger positioned at least partially within the reservoir syringe barrel. The delivery syringe barrel is configured to contain a first amount of a fluid. The reservoir syringe barrel is configured to contain a second amount of the fluid. A system includes the adjustable volume syringe, a dispensing module in communication with the syringe, and a processor in communication with the dispensing module. The processor may be configured to determine an administration amount of the fluid in the adjustable volume syringe, and transmit signals causing the dispensing module to adjust the volume of fluid in the syringe to the administration amount and deliver the administration amount by moving the reservoir syringe barrel with respect to the delivery syringe barrel.

Abstract: A drug delivery device (4) for dispensing one or more doses of a drug is provided. The device (4) comprises a drive member (1) for driving a piston rod (5) and a dose member (46) for actuating the drive member (1). The piston rod (5) is coupled to the drive member (1) such that a relative translational movement of the drive member (1) and the piston rod (5) is allowed and a relative rotational movement is prevented. The drive member (1) is configured to be driven by the dose member (46) around the longitudinal axis in a first (110) and a second rotational direction (111) opposite to each other. Furthermore, a drug delivery device (4) is provided, wherein the drive member (1) has stable and unstable states and wherein in an unstable state the drive member (1) is biased by biasing means (3) towards a stable state.

Abstract: An improved drug delivery device is provided having a piston rod that incorporates on its proximal end at least one guidepost that is configured for transmitting axial and rotational forces from a drive mechanism. The device comprises a drug delivery device housing and a medicament contained in the drug delivery device housing.

Abstract: A guide wire extender includes a coupling element for coupling to a proximal portion of a guide wire. Such a configuration enables the introduction of elongate medical instruments that lack rapid exchange features to be introduced into the body of a subject over short, rapid exchange-length guide wires. Assemblies that include a guide wire extender within an elongate medical device are also disclosed. Such an assembly may include a configuration that enables a single user to effectively lengthen a guide wire and introduce the elongate medical instrument into a subject's body without significant risk of contaminating the elongate medical instrument. Systems that include a guide wire extender and an elongate medical instrument are also disclosed, as are methods of using the guide wire extender to introduce an elongate medical instrument into the body of a subject.

Abstract: A dose control mechanism for a syringe includes a plunger having a coarse pitch screw on its exterior surface, a housing having a corresponding coarse pitch guide along the interior surface of the housing, a screw having a fine pitch screw which interfaces with a fine pitch nut of an adapter, wherein the plunger has an internal annular space within which screw at least partially resides. An accurate dose drug delivery syringe includes such a dose control mechanism, a barrel, a plunger seal, and a barrel adapter assembly having a barrel tip and a needle. The syringe may be a fill-at-time-of-use syringe, a pre-filled syringe, or a safety syringe having integrated needle retraction or needle sheathing safety features, or a combination thereof. Methods of assembly, manufacturing, and operation are similarly disclosed.

Abstract: Provided is a medicament delivery device (100) comprising a tubular housing (110), having a proximal end (111) and an opposite distal end (112), an actuator means (119, 120), slidably and coaxially arranged inside the tubular housing (110) wherein is provided an inter-locking mechanism (119, 413) between the a cap (410) and the housing (110), enabling the cap (410) to freely spin, i.e. it is impossible to open the cap (410), until the medicament delivery device (100) has been properly activated by an activator means (160).

Abstract: Apparatus for supporting a syringe includes a handle portion and a cradle. A clip is provided for connecting the plungers of two or more syringes, and two or more syringes are operated by placing one in the cradle and attaching the clip to the plungers for simultaneous operation of the plungers. The handle portion also forms a cavity for storing the clips. The apparatus is preferably used in combination with an applicator tip that combines the outputs from the two or more syringes.

Abstract: The invention relates to a syringe (20) comprising a syringe barrel (15), an ejector unit (25) arranged at the distal end of the syringe barrel (15) with a plunger rod (17), a coupling part (37) and a plunger (16) and a syringe head (21) arranged at the proximal end of the syringe barrel (15) with a needle unit (12) which is arranged in a guide sleeve (5) and is slidable therein with a cannula (3) and a cannula holder (4) and a pinion (2), by means of which the needle unit (12) is axially movable, relative to a syringe barrel (15) from a rest position to an actuation position. At the distal end of the guide sleeve (5) a sealing element (7) is arranged. The pinion (2) has at least one guide knob (1), which can be brought into engagement optionally with one of two slide tracks (10) provided in the guide sleeve (5), wherein the slide tracks (10) are inclined in opposite directions.

Abstract: An apparatus includes a label configured to be coupled to a medicament delivery device. The label includes a first surface and a second surface. The first surface is configured to be coupled to an outer surface of the medicament delivery device. The second surface includes a textual indicia. The label further includes an electronic circuit system configured to output an electronic signal.

Abstract: A needle guard device mountable to a pre-filled syringe in its ready-to-fill state. The device includes a lock collar and a device shield biased to move relative to the lock collar. The lock collar interfaces with the syringe neck to attach the device to the syringe. A flexible member interconnects the lock collar and device shield. With the removal of a needle shield assembly comprising rigid and soft needle shields, the device shield is free to move proximally along the syringe neck. As the device moves proximally, rotation arms of the lock collar interact with angled cutouts in the device shield, causing the device shield to rotate relative to the lock collar disengaging one or more keys on the device shield from one or more keyways in the lock collar triggering the device shield to move from a first configuration in which the device shield is retractable to expose a syringe sharp to a second configuration in which the device shield is fixedly positioned to cover the syringe sharp.

Abstract: An injection device (2) comprises a housing (4) in which a receiving chamber (6) is provided for an injection mechanism (8) having an injection fluid container (10) that can be pressed out by means of an injection plunger (12). The injection device (2) further comprises an actuating device (18) that can be driven for automatically pressing out the injection fluid container (10), wherein said actuating device can be displaced between an insertion/removal position outside of the receiving chamber (6) and an injection position within the receiving chamber (6), wherein the actuating device (18) is spaced by a release distance (d) from the receiving chamber (6) in the insertion/removal position. A contact mechanism (22) is provided, by means of which the actuating device (18) can be brought into a stop position in which an actuating stop (26) of the actuating device (18) contacts the injection plunger (12) and in which an injection volume adjustment (28) is automatically actuated.

Abstract: The invention relates to an auto-injector for administering a dose of a liquid medicament (M), comprising of an elongate housing arranged to contain a syringe with a hollow needle and a bung for sealing the syringe and displacing the medicament (M), the elongate housing having a distal end (D) and a proximal end (P) with an orifice intended to be applied against an injection site, wherein the syringe is slidably arranged with respect to the housing; spring means capable of, upon activation, pushing the needle from a covered position inside the housing into an advanced position through the orifice and past the proximal end (P) as well as operating the syringe to supply the dose of medicament (M); and activating means arranged to lock the spring means in a pressurized state prior to manual operation and capable of, upon manual operation, releasing the spring means for injection.

Abstract: The present invention relates to a medicament delivery device comprising a generally elongated housing (10; 100, 102), a drive assembly disposed in said hosing and an actuation assembly operably connected to said drive assembly, wherein said drive assembly comprises a guard member (12; 104) and an actuator member (44; 180), characterized in that the actuation assembly further comprises a locking member (28; 32) disposed between the guard member and the actuator member, wherein said locking member is configured to be moved by the guard member when the guard member is pressed against a delivery site between a first locking position in which the locking member is blocking the actuator member and a released position in which the locking member allows the actuator member to be operated.

Abstract: An additive force device (111) is connectible with a drug delivery device (100) to increase the amount of force exerted by a user on the dose setting knob (24) to facilitate injection. The additive force device (111) includes a first spring (121) and a loading barrel (135) connected to the first spring (121) for storing torque therein. A ratchet assembly (129) is connected to the loading barrel (135) and to the first spring (121). The ratchet assembly (129) has a first position in which torque is stored in the first spring (121) and a second position in which torque is released from the first spring (121). An inner barrel (133) is connected to the ratchet assembly and to the drug delivery device (100). The inner barrel (133) transmits the stored torque from the first spring (121) to the drug delivery device (100) to increase an injection force thereof.

Abstract: The present invention relates to a medicament delivery device comprising a drive means configured to act on a medicament container for expelling a medicament; a holding means configured to hold said drive means in a pre-tensioned state; an activation means configured to interact with said holding means for releasing said drive means from the pre-tensioned state; wherein the device further comprises feedback means configured to interact both with said holding means and with said drive means for generating an audible and/or tactile and/or visual signal indicating that the medicament has been completely expelled.

Abstract: An auto-injector for administering a dose of a liquid medicament (M) is presented having an elongate housing arranged to contain a syringe, a proximal end (P) with an orifice, wherein the syringe is slidably arranged with respect to the housing. A drive spring upon activation pushes the needle from a covered position inside the housing into an advanced position through the orifice and past the proximal end (P), and operates the syringe to supply the dose of medicament (M). An activating means locks the drive spring in a compressed state. The housing distal and a proximal portions are connected by a hinge, and are rotatable about the hinge between an aligned position and a maximum opening angle. A loading bay for holding the syringe is arranged in the proximal portion.

Abstract: An auto-injector with an interlock mechanism for defining an operation sequence in a manner to allow a lateral trigger button to be operated when a proximal end of the auto-injector is pressed against an injection site. A detector is arranged inside an elongate housing of the auto-injector at the proximal end and slidable in longitudinal direction and biased by a detector spring. A dog is arranged at the trigger button and wherein at least one longitudinal bar is provided, at least one of the bars slidable in longitudinal direction and coupled to the detector for distal movement. A recess for the dog is provided in the bar for allowing the trigger button to be pressed when the detector means is being pushed into the auto-injector and wherein otherwise the dog is engaged with the bar in a manner to prevent the trigger button from being pressed.