Proteins, I.e., More Than 100 Amino Acid Residues Patents (Class 530/350)
Lymphokines, e.g., interferons, interlukins, etc. (Class 530/351)
Phosphoproteins, e.g., phosvitin, vitellogenin, etc. (Class 530/352)
Scleroproteins, e.g., fibroin, elastin, silk, etc. (Class 530/353)
Nucleoproteins, e.g., chromatin, chromosomal proteins, histones, protamines, salmine, etc. (Class 530/358)
Lipoproteins, e.g., egg yolk proteins, cylomicrons, etc. (Class 530/359)
Casein or caseinate (Class 530/360)
Albumin (Class 530/362)
Plant proteins, e.g., derived from legumes, algae or lichens, etc. (Class 530/370)
Blood proteins or globulins, e.g., proteoglycans, platelet factor 4, thyroglobulin, thyroxine, etc. (Class 530/380)
Glycoprotein, e.g., mucins, proteoglycans, etc. (Class 530/395)
Hormones, e.g., prolactin, thymosin, growth factors, etc. (Class 530/399)
Metal containing, e.g., chromoproteins, ferritin, ferredoxins, etc. (Class 530/400)
Chemical modification or the reaction product thereof, e.g., covalent attachment or coupling, etc. (Class 530/402)
Separation or purification (Class 530/412)
  • DENGUE SEROTYPE 2 ATTENUATED STRAIN
    Publication number: 20150031857
    Abstract: The invention relates to live attenuated VDV2 (VERO-Derived Vaccine Dengue serotype 2) strains which have been derived from the wild-type dengue-2 strain 16681 by passaging on PDK and Vero cells and nucleic acids thereof. The invention further relates to a vaccine composition which comprises a VDV2 strain.
    Type: Application
    Filed: August 4, 2014
    Publication date: January 29, 2015
    Inventors: Richard KINNEY, Claire Y.H. Kinney, Veronique Barban, Jean Lang, Bruno Guy
  • APTAMER MODULATORS OF ESTROGEN RECEPTORS
    Publication number: 20150031754
    Abstract: The present invention relates to a nucleic acid aptamer molecule that includes a domain that binds to an estrogen receptor, molecular complexes that include the nucleic acid aptamer molecule and an estrogen receptor, and constructed DMA molecules and expression systems, as well as host cells, that the contain an RNA aptamer molecule of the invention. Use of these aptamers and encoding constructs to inhibiting estrogen receptor activity in a cell and to treat estrogen receptor-positive cancers is also described.
    Type: Application
    Filed: August 16, 2012
    Publication date: January 29, 2015
    Applicant: RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK AT ALBANY
    Inventors: Hua Shi, Daiying Xu, Vamshee Krishna Chatakonda
  • COMPUTATIONALLY OPTIMIZED BROADLY REACTIVE ANTIGENS FOR INFLUENZA
    Publication number: 20150030628
    Abstract: The development of a computationally optimized influenza HA protein that elicits broadly reactive immune response to all H5N1 influenza virus isolates is described. The optimized HA protein was developed through a series of HA protein alignments, and subsequent generation of consensus sequences, for clade 2 H5N1 influenza virus isolates. The final consensus HA amino acid sequence was reverse translated and optimized for expression in mammalian cells. Influenza virus-like particles containing the optimized HA protein are an effective vaccine against H5N1 influenza virus infection in animals.
    Type: Application
    Filed: October 10, 2014
    Publication date: January 29, 2015
    Inventors: Ted M. Ross, Brendan M. Giles
  • METHODS AND COMPOSITIONS FOR EMERGENCY POST-INFECTION TREATMENT OF ANTHRAX
    Publication number: 20150033410
    Abstract: Compositions effective for treating or preventing an anthrax infection in a subject in need thereof and recombinant proteins included in the compositions are provided. Methods for producing recombinant proteins in plants are described. Transgenic plants engineered to produce recombinant proteins as well as genetic constructs comprising nucleic acids encoding recombinant proteins thereof are also described. Methods of protecting subjects against anthrax infection with plant-derived compositions are provided.
    Type: Application
    Filed: June 20, 2013
    Publication date: January 29, 2015
    Inventors: Vyacheslav Andrianov, Maxim Golovkin
  • ANTI-MESOTHELIN CHIMERIC ANTIGEN RECEPTORS
    Publication number: 20150031624
    Abstract: The invention provides a chimeric antigen receptor (CAR) (a) an antigen binding domain of HN1 or SS, a transmembrane domain, and an intracellular T cell signaling domain, or (b) an antigen binding domain of SS1, a transmembrane domain, an intracellular T cell signaling domain, and a granulocyte-macrophage colony-stimulating factor (GM-CSF) receptor 2 leader. Nucleic acids, recombinant expression vectors, host cells, populations of cells, antibodies, or antigen binding portions thereof, and pharmaceutical compositions relating to the CARs are disclosed. Methods of detecting the presence of cancer in a mammal and methods of treating or preventing cancer in a mammal are also disclosed.
    Type: Application
    Filed: March 5, 2013
    Publication date: January 29, 2015
    Inventors: Steven A. Feldman, Steven A. Rosenberg, Ira H. Pastan
  • TRANSPORT PROTEIN WHICH IS USED TO INTRODUCE CHEMICAL COMPOUNDS INTO NERVE CELLS
    Publication number: 20150030584
    Abstract: The invention relates to a transport protein which can be obtained by modifying the heavy chain of the neurotoxin formed by Clostridium botulinum. The protein binds specifically to nerve cells with a higher affinity as the native neurotoxin. The invention also relates to a method for the production of transport protein, the nucleic acids coding for the transport protein, the transport protein containing pharmaceutical and cosmetic compositions and use thereof.
    Type: Application
    Filed: August 5, 2014
    Publication date: January 29, 2015
    Applicant: SYNTAXIN LIMITED
    Inventor: Andreas Rummel
  • Methods of Stimulating Protective Immunity Employing Dengue Viral Antigens
    Publication number: 20150031858
    Abstract: Compositions that include at least a portion of at least one pathogen-associated molecular pattern and at least a portion of at least one member selected from the group consisting of a Den1 viral envelope protein, a Den2 viral envelope protein, a Den3 viral envelope protein and a Den4 viral envelope protein are employed in methods to stimulate a protective immune response in a subject.
    Type: Application
    Filed: September 23, 2014
    Publication date: January 29, 2015
    Inventors: Thomas J. Powell, Valerian Nakaar, Langzhou Song, James W. Huleatt, William F. McDonald, Duane D. Hewitt
  • SELF-ASSEMBLED NANOSTRUCTURES
    Publication number: 20150031127
    Abstract: The present disclosure is directed to the preparation of nanostructures by the encapsulation of a charged compound with individual self-assembled unit nano structures.
    Type: Application
    Filed: August 31, 2012
    Publication date: January 29, 2015
    Applicant: NORTHWESTERN UNIVERSITY
    Inventors: Samuel I. Stupp, Yves Ruff
  • Anaplastic Lymphoma Kinase (ALK) As An Oncogene Capable Of Transforming Normal Human Cells
    Publication number: 20150031856
    Abstract: The present invention provides compositions and methods for transforming primary mammalian cells using an oncogenic form of ALK wherein the transformed cells display features of that of a corresponding tumor cell isolated from a cancer subject. The invention also provides a method for immortalizing normal CD4+ T lymphocytes with a lymphoma-characteristic form of ALK such as NPM-ALK.
    Type: Application
    Filed: March 5, 2014
    Publication date: January 29, 2015
    Inventors: Mariusz Wasik, James L. Riley, Qian Zhang, Fang Wei
  • GAS57 MUTANT ANTIGENS AND GAS57 ANTIBODIES
    Publication number: 20150030625
    Abstract: The invention provides mutants of GAS57 (Spy0416) which are unable to cleave IL-8 and similar substrates but which still maintain the ability to induce protection against S. pyogenes. The invention also provides antibodies which specifically bind to GAS57 and which inhibit its ability to cleave IL-8 and similar substrates. The mutants are useful, inter alia, in vaccine compositions to induce protection against S. pyogenes. The antibodies are useful, e.g., as therapeutics for treating S. pyogenes infections.
    Type: Application
    Filed: October 13, 2014
    Publication date: January 29, 2015
    Inventors: Immaculada Margarit Y Ros, Guido Grandi, Chiara Zingaretti
  • ANTI-EGFR ANTIBODY AND ANTI-C-MET/ANTI-EGFR BISPECIFIC ANTIBODIES COMPRISING THE SAME
    Publication number: 20150030599
    Abstract: An anti-EGFR scFV fragment, an anti-c-Met/anti-EGFR bispecific antibody including the same, and a method of preventing and/or treating a cancer using the same are provided.
    Type: Application
    Filed: July 29, 2014
    Publication date: January 29, 2015
    Inventors: Mi Young CHO, Seung Hyun Lee, Kwang Ho Cheong, Young Jun Koh, Jung Wook Lee, Powei Lin, Jae Woong Hwang
  • Methods for Enhancing Bacterial Cell Display of Proteins and Peptides
    Publication number: 20150031855
    Abstract: Methods of making and using bacterial display polypeptide libraries using circularly permuted OmpX (CPX) variants are disclosed. The invention further relates to methods for enhancing the display of proteins and peptides at the surface of bacteria by optimizing linkers and incorporating mutations at positions 165 and 166 of CPX.
    Type: Application
    Filed: September 13, 2012
    Publication date: January 29, 2015
    Inventors: PATRICK S. DAUGHERTY, Jeffrey Rice
  • Hybrid fibers, devices using hybrid fibers, and methods for making hybrid fibers
    Patent number: 8940092
    Abstract: The present invention relates generally to nanocomposite materials. The present invention relates more particularly to hybrid fibers as well as devices including them and methods for making them. Accordingly, one aspect of the invention is a hybrid fiber including a plurality of nanowires, each nanowire having a length, a width, and a thickness, the length being at least 10 times the width and at least 10 times the thickness; and a plurality of binder elements, each binder element having a length, a width, and a thickness, each substantially smaller than the average length of the nanowires and at least one of which is less than about 10 nm in dimension, the binder elements being arranged to intercouple individual nanowires. In certain embodiments, the binder elements are carbon nanotubes, and the nanowires are formed from silicon carbide.
    Type: Grant
    Filed: September 26, 2012
    Date of Patent: January 27, 2015
    Assignee: University of Washington through its Center for Commercialization
    Inventors: Woon-Hong Yeo, Kieseok Oh, Kyong-Hoon Lee, Fong-Li Chou, Jae-Hyun Chung
  • Urate transporter, as well as method and kit for evaluating urate transport-related disease factor and inflammation-related disease factor, and test sample and drug
    Patent number: 8940286
    Abstract: A method and evaluation kit are provided, in which a high-capacity urate transporter is identified to assist in the early treatment and prevention of urate transport-related disease and inflammation-related disease. The method can include a step for detecting variations in genes that encode ABCG2 protein. When a subject has an SNP of V12M, R113X, Q126X, Q141K, F208S, G268R, E334X, S441N, L447V, S486N, F506SfsX4, R575X, and/or C608X, it can be concluded that the subject has a factor that is capable of inducing urate transport failure, or a state or disease attributable to that failure. When a subject has an SNP of V12M, it can be concluded that, unlike the other SNPs, there is a possibility that the subject does not possess such a factor because, although this variation itself does not lead to a change in urate transport capability, said variation is related to linkage disequilibrium with other SNPs.
    Type: Grant
    Filed: June 22, 2010
    Date of Patent: January 27, 2015
    Assignees: The University of Tokyo, Tokyo University of Pharmacy and Life Sciences
    Inventors: Hirotaka Matsuo, Nariyoshi Shinomiya, Takahiro Nakamura, Tappei Takada, Hiroshi Suzuki, Yuki Ikebuchi, Kousei Ito, Kimiyoshi Ichida
  • Engineered anti-prostate stem cell antigen (PSCA) antibodies for cancer targeting
    Patent number: 8940871
    Abstract: The invention provides novel humanized antibody fragments that specifically bind prostate cell-surface antigen (PSCA), a protein which is overexpressed in variety of cancers, including prostate, bladder, and pancreatic cancer. Methods are provided for the use of the compositions of the invention for the treatment of cancer, diagnosis of cancer, to provide a prognosis of cancer progression, and for cancer imaging.
    Type: Grant
    Filed: March 20, 2007
    Date of Patent: January 27, 2015
    Assignee: The Regents of the University of California
    Inventors: Anna M. Wu, Robert E. Reiter
  • Plants and seeds of hybrid corn variety CH286440
    Patent number: 8940981
    Abstract: According to the invention, there is provided seed and plants of the hybrid corn variety designated CH286440. The invention thus relates to the plants, seeds and tissue cultures of the variety CH286440, and to methods for producing a corn plant produced by crossing a corn plant of variety CH286440 with itself or with another corn plant, such as a plant of another variety. The invention further relates to genetic complements of plants of variety CH286440.
    Type: Grant
    Filed: May 2, 2012
    Date of Patent: January 27, 2015
    Assignee: Monsanto Technology LLC
    Inventors: Michael Dragonuk, Chris Eichhorn, Peter Guzman, Gregory J. Holland, Michael A. Josephs, Jeffrey L. McElroy, Laron L. Peters, Hector Ramirez de Leon, Christopher L. Souder
  • Process for protein extraction
    Patent number: 8940875
    Abstract: The invention includes a process for extracting a target protein from Escherichia coli cells that includes lowering the pH of a whole E. coli cell solution to form an acidic solution, disrupting the cells to release the protein into the acidic solution, and separating the cellular debris from the released protein to obtain a protein product enriched in the heterologous target protein. The invention also includes addition of a solubility enhancer.
    Type: Grant
    Filed: June 29, 2012
    Date of Patent: January 27, 2015
    Assignee: Genentech, Inc.
    Inventor: Richard L. Gehant
  • Method and system for detecting and differentiating cancer and sepsis in mammals using biomarkers
    Patent number: 8940869
    Abstract: The invention provides a method and system for developing and using diagnoses of cancer and sepsis in canine subjects using Thymidine kinase (TK), c-reactive protein (CRP), and C-type natriuretic peptide (CNP) as biomarkers. The level of each biomarker may be measured and an index may be computed using a two- or a three-biomarker method. The invention provides a predefined scale for the index where each range of the index matches a health condition. The latter allows a practitioner, through computing an index value of a patient, to determine the health status of the patient by comparing the index value to the predefined scale.
    Type: Grant
    Filed: November 8, 2012
    Date of Patent: January 27, 2015
    Assignee: Veterinary Diagnostics Institute, Inc.
    Inventor: Randy Ringold
  • E-selectin compositions and use thereof for inducing E-selectin tolerance
    Patent number: 8940700
    Abstract: The invention relates to compositions and methods for treating or preventing vascular dementia in a mammal comprising mucosal administration of an amount of E-selectin polypeptide sufficient to induce bystander immune tolerance in the mammal. Another aspect of the invention relates to compositions useful for treating or preventing vascular dementia.
    Type: Grant
    Filed: August 18, 2010
    Date of Patent: January 27, 2015
    Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services, National Institutes of Health
    Inventors: John M. Hallenbeck, Hideaki Wakita
  • High-sensitive fluorescent energy transfer assay using fluoresent amino acids and fluorescent proteins
    Patent number: 8940506
    Abstract: The disclosure provides method and composition utilizing fluorescent amino acids and endogenous fluorescent proteins comprising a moiety capable of undergoing FRET. The methods and compositions of the disclosure are useful in analyzing protein structure and function, and screening molecular inhibitors.
    Type: Grant
    Filed: March 21, 2009
    Date of Patent: January 27, 2015
    Assignee: The Regents of the University of California
    Inventors: Jiayu Liao, Yang Song, Yongfeng Zhao, Yan Liu
  • Plants and seeds of hybrid corn variety CH439482
    Patent number: 8940982
    Abstract: According to the invention, there is provided seed and plants of the hybrid corn variety designated CH439482. The invention thus relates to the plants, seeds and tissue cultures of the variety CH439482, and to methods for producing a corn plant produced by crossing a corn plant of variety CH439482 with itself or with another corn plant, such as a plant of another variety. The invention further relates to genetic complements of plants of variety CH439482.
    Type: Grant
    Filed: May 2, 2012
    Date of Patent: January 27, 2015
    Assignee: Monsanto Technology LLC
    Inventor: Belgin Cukadar
  • Tomato variety picus
    Patent number: 8940975
    Abstract: The invention provides seed and plants of the tomato variety designated Picus. The invention thus relates to the plants, seeds and tissue cultures of tomato variety Picus and to methods for producing a tomato plant produced by crossing a plant of tomato variety Picus with itself or with another tomato plant, such as a plant of another variety. The invention further relates to seeds and plants produced by such crossing, and also relates to parts of a plant of tomato variety Picus including the fruit and gametes of such plants. The invention also relates to tomato variety FDS 14-2081, and to seeds and plants produced by crossing a plant of tomato variety FDS 14-2081 with itself or another tomato plant. The present invention is also directed to tomato variety FDS 14-2090, and to seeds and plants produced by crossing a plant of tomato variety FDS 14-2090 with itself or another tomato plant.
    Type: Grant
    Filed: February 13, 2012
    Date of Patent: January 27, 2015
    Assignee: Seminis Vegetable Seeds, Inc.
    Inventor: Charles W. Fowler
  • Variants of ancestral uricases and uses thereof
    Patent number: 8940861
    Abstract: The present invention provides uricases and methods of their production and use in reducing the amount of uric acid in a subject. The present invention further provides methods employing a uricase of this invention in the treatment and/or prevention of hyperuricemia, gout, tumor lysis syndrome and/or hypertension in a subject.
    Type: Grant
    Filed: April 8, 2011
    Date of Patent: January 27, 2015
    Assignee: Georgia Tech Research Corporation
    Inventor: Eric A. Gaucher
  • Host cell protein knock-out cells for production of therapeutic proteins
    Patent number: 8940504
    Abstract: The present invention relates to methods and means for making Vitamin K-dependent protein compositions which are devoid or substantially devoid of protein contaminants. In particular, methods and means useful for the reduction or elimination of protein contaminants also being Vitamin K-dependent proteins are described.
    Type: Grant
    Filed: March 13, 2012
    Date of Patent: January 27, 2015
    Assignee: Novo Nordisk Healthcare AG
    Inventors: Thomas Dock Steenstrup, Peder Lisby Norby
  • Fusion proteins
    Patent number: 8940870
    Abstract: A single chain, polypeptide fusion protein, comprising: a non-cytotoxic protease, or a fragment thereof, which protease or protease fragment is capable of cleaving a protein of the exocytic fusion apparatus of a nociceptive sensory afferent; a dynorphin Targeting Moiety that is capable of binding to a Binding Site on the nociceptive sensory afferent, which Binding Site is capable of undergoing endocytosis to be incorporated into an endosome within the nociceptive sensory afferent; a protease cleavage site at which site the fusion protein is cleavable by a protease, wherein the protease cleavage site is located between the non-cytotoxic protease or fragment thereof and the dynorphin Targeting Moiety; and a translocation domain that is capable of translocating the protease or protease fragment from within an endosome, across the endosomal membrane and into the cytosol of the nociceptive sensory afferent.
    Type: Grant
    Filed: February 22, 2013
    Date of Patent: January 27, 2015
    Assignees: Syntaxin, Ltd., Allergan, Inc.
    Inventors: Keith Foster, John Chaddock, Philip Marks, Patrick Stancombe, Kei Roger Aoki, Joseph Francis, Lance Steward
  • Tomato variety EX01419137
    Patent number: 8940974
    Abstract: The invention provides seed and plants of the tomato variety designated EX01419137. The invention thus relates to the plants, seeds and tissue cultures of tomato variety EX01419137 and to methods for producing a tomato plant produced by crossing a plant of tomato variety EX01419137 with itself or with another tomato plant, such as a plant of another variety. The invention further relates to seeds and plants produced by such crossing. The invention further relates to parts of a plant of tomato variety EX01419137 including the fruit and gametes of such plants. The invention also relates to tomato variety CHI 14-2079. The present invention is also directed to tomato variety CHD 14-2080.
    Type: Grant
    Filed: October 24, 2011
    Date of Patent: January 27, 2015
    Assignee: Seminis Vegetable Seeds, Inc.
    Inventor: James D. Frantz
  • Tomato line PSQ-9Z06019
    Patent number: 8940976
    Abstract: The invention provides seed and plants of tomato hybrid PX 02461513 and the parent lines thereof. The invention thus relates to the plants, seeds and tissue cultures of tomato hybrid PX 02461513 and the parent lines thereof, and to methods for producing a tomato plant produced by crossing such plants with themselves or with another tomato plant, such as a plant of another genotype. The invention further relates to seeds and plants produced by such crossing. The invention further relates to parts of such plants, including the fruit and gametes of such plants.
    Type: Grant
    Filed: April 6, 2012
    Date of Patent: January 27, 2015
    Assignee: Seminis Vegetable Seeds, Inc.
    Inventors: Teresa Beck Bunn, Giulio Bile
  • Elastin based growth factor delivery platform for wound healing and regeneration
    Patent number: 8940868
    Abstract: The invention is based on the discovery of a potent growth factor delivery system by creating a fusion polypeptide that includes two portions: (i) keratinocyte growth factor protein, and (ii) an elastin-like peptide. This chimera can be administered directly to a wound site, accelerating recovery.
    Type: Grant
    Filed: October 6, 2010
    Date of Patent: January 27, 2015
    Assignee: The General Hospital Corporation
    Inventors: Piyush Koria, Martin L. Yarmush, Yaakov Nahmias
  • Methods for ligation and uses thereof
    Patent number: 8940501
    Abstract: The present invention relates to methods for ligation. The invention provides novel reagents and methods for ligating an acyl donor compound with an acyl acceptor compound. Provided acyl donor compounds comprise a transamidase recognition sequence that allows ligation with a nucleophilic acyl acceptor in the presence of transamidase. The invention further provides kits comprising acyl donor compounds and optionally comprising other reagents for ligation.
    Type: Grant
    Filed: February 1, 2010
    Date of Patent: January 27, 2015
    Assignee: Whitehead Institute for Biomedical Research
    Inventors: Hidde L. Ploegh, John M. Antos, Maximilian Wei-Lin Popp, Carla Guimaraes
  • Flt4 (VEGFR-3) as a target for tumor imaging and anti-tumor therapy
    Patent number: 8940695
    Abstract: The present invention provide purified Flt4 receptor tyrosine kinase polypeptides and fragments thereof, polynucleotides encoding such polypeptides, antibodies that specifically bind such polypeptides, and uses therefor.
    Type: Grant
    Filed: January 6, 2006
    Date of Patent: January 27, 2015
    Assignee: Vegenics Pty Limited
    Inventors: Kari Alitalo, Taija Makinen
  • Polypeptides having xylanase activity and polynucleotides encoding same
    Patent number: 8940515
    Abstract: The present invention relates to isolated polypeptides having xylanase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.
    Type: Grant
    Filed: November 8, 2010
    Date of Patent: January 27, 2015
    Assignee: Novozymes, Inc.
    Inventors: Alfredo Lopez de Leon, Michael Rey
  • Processes for synthesizing alkaline phosphatase conjugates
    Patent number: 8940512
    Abstract: Methods for synthesizing an ALP conjugate are provided. The methods may include activating a carboxyl group of the ALP with a carbodiimide, to generate an active ester; and adding the substance to be conjugated such that a synthetic reaction occurs between the active ester and the substance to be conjugated, to generate an ALP conjugate.
    Type: Grant
    Filed: June 2, 2011
    Date of Patent: January 27, 2015
    Assignee: Shenzhen Mindray Bio-Medical Electronics Co., Ltd.
    Inventors: Chungen Qian, Ke Li, Yuping Zhang
  • High affinity anti-prostate stem cell antigen (PSCA) antibodies for cancer targeting and detection
    Patent number: 8940298
    Abstract: The present invention provides novel high affinity antibodies and fragments thereof that bind to the cancer antigen PSCA. The antibodies of the present invention may be used for cancer diagnosis, prognosis, treatment, visualization, and the like. The present invention also provides methods for the detection, visualization, and treatment of various cancers expressing PSCA.
    Type: Grant
    Filed: September 4, 2008
    Date of Patent: January 27, 2015
    Assignee: The Regents of the University of California
    Inventors: Anna M. Wu, Robert E. Reiter, Eric J. Lepin, James D. Marks, Yu Zhou
  • VIRUS-LIKE PARTICLES COMPRISING COMPOSITE CAPSID AMINO ACID SEQUENCES FOR ENHANCED CROSS REACTIVITY
    Publication number: 20150023995
    Abstract: The present invention provides polypeptides having a composite amino acid sequence derived from a consensus sequence representing the capsid proteins of two or more circulating strains of a non-enveloped virus. In particular, the invention provides virus-like particles comprising at least one composite polypeptide. Such virus-like particles have antigenic epitopes of two or more circulating strains of a non-enveloped virus and produce an increase in antisera cross-reactivity to one or more circulating strains of the non-enveloped virus. Methods of making composite virus-like particles and vaccine formulations comprising composite virus-like particles are also disclosed.
    Type: Application
    Filed: July 25, 2014
    Publication date: January 22, 2015
    Applicant: TAKEDA VACCINES, INC.
    Inventors: Charles RICHARDSON, Robert F. BARGATZE, Joel HAYNES, Bryan STEADMAN
  • T1R Hetero-Oligomeric Taste Receptors
    Publication number: 20150024407
    Abstract: Newly identified mammalian taste-cell-specific G protein-coupled receptors which function as hetero-oligomeric complexes in the sweet taste transduction pathway, and the genes and cDNA encoding said receptors are described. Specifically, T1R G protein-coupled receptors active in sweet taste signaling as hetero-oligomeric complexes, and the genes and cDNA encoding the same, are described, along with methods for isolating such genes and for isolating and expressing such receptors. Methods for identifying putative taste modulating compounds using such hetero-oligomeric complexes also described, as is a novel surface expression facilitating peptide useful for targeting integral plasma membrane proteins to the surface of a cell.
    Type: Application
    Filed: July 22, 2014
    Publication date: January 22, 2015
    Inventors: Jon E. ADLER, Xiaodong LI, Lena STASZEWSKI, Hong XU, Fernando ECHEVERRI
  • Novel Targets of Acinetobacter Baumannii
    Publication number: 20150023999
    Abstract: The present invention provides antigenic polypeptides expressed during an infection by a pathogenic organism, such as Acinetobacter and compositions comprising these polypeptides. The invention further provides compositions for use in treating, preventing or detecting a bacterial infection, in particular vaccine compositions using the antigenic polypeptides. The invention further provides antibodies directed to said antigenic polypeptides.
    Type: Application
    Filed: November 29, 2012
    Publication date: January 22, 2015
    Inventors: Simon Urwyler, Markus Haake, Michael Rodolf
  • TOLL-LIKE RECEPTOR 2 BINDING EPITOPE AND BINDING MEMBER THERETO
    Publication number: 20150023974
    Abstract: The present invention relates to the identification of a TLR2 binding epitope wherein binding of a binding member to the epitope serves to inhibit TLR2 activation and/or signalling. Polypeptide fragments of TLR2 and three-dimensional structures comprising one or more amino acid residues His318, Pro320, Gln321 or Arg321, Tyr323, Lys347, Phe349, Leu371, Glu375, Tyr376 and His398 of TLR2 which define the identified epitope are provided for use in generating binding members. Also provided are binding members which bind to the identified epitope and methods of using same for the treatment and/or prevention of conditions associated with TLR2 activation and/or signalling.
    Type: Application
    Filed: March 29, 2013
    Publication date: January 22, 2015
    Inventors: Nils Kuklik, Wolf-Dieter Schubert
  • Immunogenic Compositions and Methods
    Publication number: 20150024038
    Abstract: The invention is directed to immunogenic compositions and methods for their use in the formulation and administration of therapeutic and prophylactic pharmaceutical agents. In particular, the invention provides immunogenic compositions and methods for preventing, treating, and/or ameliorating the symptoms of one or more microbial infections, including, for example, influenza.
    Type: Application
    Filed: August 29, 2014
    Publication date: January 22, 2015
    Inventors: Gerald W. Fischer, Luke T. Daum
  • ENGINEERED PEPTIDE (EP)-DIRECTED PROTEIN INTERCELLULAR DELIVERY SYSTEM AND USES THEREOF
    Publication number: 20150023932
    Abstract: The present invention provides an intercellular protein delivery system comprising an engineered peptide (EP), composed of secretion part (SP) and nuclear translocation part (NTP), a functional or therapeutic protein (FP), cells that express the fusion proteins and cells that accept the fusion proteins. The system can be used in vivo or in vitro to sustainably supply proteins of interest for cellular reprogramming, cellular differentiation and cell-based protein therapies.
    Type: Application
    Filed: July 17, 2013
    Publication date: January 22, 2015
    Inventors: KE-KE FAN, Jing Bian
  • Xenoantigen-Displaying Anti-Cancer Vaccines and Method of Making
    Publication number: 20150024037
    Abstract: Compositions, methods of making, and methods of using, xenoantigen-displaying anticancer vaccines are described. In another broad aspect, there is provided herein a method of synthesizing an alkynefunctionalized composition of claim 1, comprising: deprotecting an ester comprising a Fmoc moiety to form a free acid; coupling the free acid of step (a) with an amine; and, removing the Fmoc moiety, and coupling the remaining moiety with palmitic acid to yield an alkyne-functionalized composition.
    Type: Application
    Filed: February 15, 2013
    Publication date: January 22, 2015
    Applicant: THE UNIVERSITY OF TOLEDO
    Inventors: Steven J. Sucheck, Katherine A. Wall, Sourav Sarkar
  • RECOMBINANT VAPA AND VAPC PEPTIDES AND USES THEREOF
    Publication number: 20150023983
    Abstract: The present invention provides a recombinant protein comprising consecutive amino acids, the sequence of which is substantially identical to a sequence of amino acids present in a Rhodococcus equi virulence-associated protein and compositions containing fusion proteins of the invention. The present invention also provides uses of the compositions in the manufacture of hyperimmune plasma against Rhodococcus equi, in producing a hyperimmune plasma against Rhodococcus equi in protecting an animal against Rhodococcus equi and in protecting a newborn animal against Rhodococcus equi.
    Type: Application
    Filed: March 13, 2014
    Publication date: January 22, 2015
    Applicant: SANTA CRUZ BIOTECHNOLOGY, INC.
    Inventor: John R. Stephenson
  • VARIANT AAV AND COMPOSITIONS, METHODS AND USES FOR GENE TRANSFER TO CELLS, ORGANS AND TISSUES
    Publication number: 20150023924
    Abstract: The invention relates to adeno-associated virus (AAV) serotype AAV-Rh74 and related AAV vectors, and AAV-Rh74 and related AAV vector mediated gene transfer methods and uses. In particular, AAV-Rh74 and related AAV vectors target polynucleotides to cells, tissues or organs for expression (transcription) of genes encoding therapeutic proteins and peptides, and polynucleotides that function as or are transcribed into inhibitory nucleic acid sequences.
    Type: Application
    Filed: July 22, 2014
    Publication date: January 22, 2015
    Inventors: Katherine High, Mustafa Yazicioglu, Xavier Anguela
  • Human G-protein chemokine receptor HSATU68
    Patent number: 8937169
    Abstract: Human G-protein chemokine receptor polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptides for identifying antagonists and agonists to such polypeptides and methods of using the agonists and antagonists therapeutically to treat conditions related to the underexpression and overexpression of the G-protein chemokine receptor polypeptides, respectively. Also disclosed are diagnostic methods for detecting a mutation in the G-protein chemokine receptor nucleic acid sequences and detecting a level of the soluble form of the receptors in a sample derived from a host.
    Type: Grant
    Filed: January 31, 2011
    Date of Patent: January 20, 2015
    Assignee: Human Genome Sciences, Inc.
    Inventor: Yi Li
  • Saposin C-DOPS: a novel anti-tumor agent
    Patent number: 8937156
    Abstract: Compositions and methods for treating subjects with disorders characterized by hyper-proliferating cells such as tumors and cancers are provided. The compositions comprise agents that are combinations of saposin C (or prosaposin-related polypeptides) and phospholips (or inner leaflet components). This anti-tumor agent is administered in the methods of the invention according to a dosing regimen. Administering an agent of the invention results in a positive therapeutic response in a subject with a tumor.
    Type: Grant
    Filed: December 11, 2008
    Date of Patent: January 20, 2015
    Assignee: Children's Hospital Medical Center
    Inventor: Xiaoyang Qi
  • Injection paradigm for administration of botulinum toxins
    Patent number: 8936790
    Abstract: Disorders such as headaches can be treated by administration of a botulinum toxin to a patient suffering therefrom, such as a migraine headache. A combined a fixed site/fixed dose and an optional follow the pain variable dosage and injection site paradigm is disclosed for optimizing clinical effectiveness of botulinum toxin administration for patients suffering headache, particularly chronic migraine.
    Type: Grant
    Filed: April 16, 2013
    Date of Patent: January 20, 2015
    Assignee: Allergan, Inc.
    Inventors: Catherine C. Turkel, Sheena K. Aurora, Mitchell F. Brin
  • Tomato hybrid PS02326502
    Patent number: 8937226
    Abstract: The invention provides seed and plants of tomato hybrid PS02326502 and the parent lines thereof. The invention thus relates to the plants, seeds and tissue cultures of tomato hybrid PS02326502 and the parent lines thereof, and to methods for producing a tomato plant produced by crossing such plants with themselves or with another tomato plant, such as a plant of another genotype. The invention further relates to seeds and plants produced by such crossing. The invention further relates to parts of such plants, including the fruit and gametes of such plants.
    Type: Grant
    Filed: January 5, 2012
    Date of Patent: January 20, 2015
    Assignee: Seminis Vegetable Seeds, Inc.
    Inventor: Giulio Bile
  • Therapeutic nuclease compositions and methods
    Patent number: 8937157
    Abstract: Hybrid nuclease molecules and methods for treating an immune-related disease or disorder in a mammal, and a pharmaceutical composition for treating an immune-related disease in a mammal.
    Type: Grant
    Filed: February 6, 2014
    Date of Patent: January 20, 2015
    Assignee: University of Washington
    Inventors: Jeffrey A. Ledbetter, Martha Hayden-Ledbetter, Keith Elkon, Xizhang Sun
  • Liquid formulations of tumor necrosis factor-binding proteins
    Patent number: 8937045
    Abstract: The invention relates to a stable, pharmaceutically acceptable, aqueous formulation of TNF-binding protein, comprising a TNF-binding protein, a buffer and an isotonicity agent.
    Type: Grant
    Filed: February 11, 2004
    Date of Patent: January 20, 2015
    Assignee: Ares Trading S.A.
    Inventors: Fabrizio Samaritani, Alessandra Del Rio, Rita Agostinetto
  • Tomato hybrid PS02450650 and parent lines thereof
    Patent number: 8937225
    Abstract: The invention provides seed and plants of tomato hybrid PS02450650 and the parent lines thereof. The invention thus relates to the plants, seeds and tissue cultures of tomato hybrid PS02450650 and the parent lines thereof, and to methods for producing a tomato plant produced by crossing such plants with themselves or with another tomato plant, such as a plant of another genotype. The invention further relates to seeds and plants produced by such crossing. The invention further relates to parts of such plants, including the fruit and gametes of such plants.
    Type: Grant
    Filed: January 5, 2012
    Date of Patent: January 20, 2015
    Assignee: Seminis Vegetable Seeds, Inc.
    Inventor: Teresa Beck Bunn
  • Compositions, methods and uses
    Patent number: 8937153
    Abstract: The present invention relates to a class of engineered polypeptides having a binding affinity for albumin. It also relates to new methods and uses that exploit binding by these and other compounds to albumin in different contexts, some of which have significance for the treatment of disease in mammals including humans.
    Type: Grant
    Filed: July 17, 2008
    Date of Patent: January 20, 2015
    Assignee: Affibody AB
    Inventors: Lars Abrahmsén, Andreas Jonsson, Jakob Dogan, Per-Åke Nygren