Abstract: An inflation syringe having an improved display and method of displaying pressurization information. More particularly, the present invention relates to methods and apparatuses for providing both numeric and non-numeric indications of an inflation pressurization associated with an inflation syringe. According to one embodiment of the present invention, a progressive non-numeric display is provided for displaying the pressurization of the inflation syringe along with numeric indicators of the pressurization. The progressive display includes a plurality of indicia corresponding to a range of inflation pressurization values. The indicia are actuated to indicate inflation pressurization and to allow the practitioner to not only easily monitor the general intensity of the pressurization but to monitor changes in the pressurization without needing to interpret numerical values.

Abstract: An injection device assembly includes a dispensing chamber housing and a plunger. The dispensing chamber housing is coupled to a needle. The dispensing chamber housing has an inner surface and an outer surface. The inner surface partially defines a dispensing chamber for holding a quantity of a substance. A dosage of a substance is cast into the dispensing chamber housing or cast onto a plunger that is inserted into the dispensing chamber housing.

Abstract: A stopper adapted for attachment with a plunger rod for use within a syringe barrel is disclosed. The stopper includes a main body defining an open rearward end and a closed front end. The open rearward end is adapted to receive a front forward end attachment portion of the plunger rod. The stopper also includes a core member integrally formed with the main body adjacent the closed front end. The core member includes a nose portion having a conical tip configured for entering an outlet opening of the syringe barrel. The closed front end of the stopper has a profile configured to cooperate with an internal surface of the syringe barrel wall to prevent reflux and reduce dead space within the barrel.

Abstract: A method for formulating T-cells for use as a medicant comprises activating the T-cells by incubating the T-cells in a nutrient culture media with an activating agent. The T-cells together with the activating agent are suspended in a media suitable for infusion. The activated T-cells are packaged together with the activating agent in a container suitable for administration to a patient.

Abstract: A pharmaceutical composition for the acute and/or chronic treatment or prevention of osteoarticular diseases includes an adequate pharmaceutical carrier or diluent, a polysaccharide and/or a glycosaminoglycan, an anti-inflammatory agent and stem cells.

Abstract: Drug depot delivery devices and methods are provided for delivering one or more drug depots in close proximity to the nerve of a patient with or without repositioning the cannula. The device includes an electronic monitor for detecting the proximity of the tip of the cannula to a nerve. In some embodiments, a method of delivering a drug depot is provided by detecting the nerve and delivering the drug depot near the nerve.

Abstract: A retractable syringe, plunger and releasable needle retaining assembly are provided. The retractable syringe typically has a glass barrel and is prefilled with fluid contents before use. The releasable needle retaining system comprises a retractable needle, a needle seal, a retaining member and an ejector member that is operable to release the retractable needle from the retaining member. The retaining member has a mating surface for mounting to a complementary mating surface of an interior wall of a syringe barrel. The plunger comprises a plunger outer, a plunger rod frangibly connected to a controlling member, a spring and a unitary plunger seal capable of engaging the retractable needle, wherein the plunger rod, plunger outer and the controlling member co-operate to releasably maintain the spring in an initially compressed state. After delivery of fluid contents of the syringe, the plunger forces the ejector member to release the retractable needle from the retaining member.

Abstract: The invention concerns a device for injecting a viscous fluid into the body, including: a tubular structure defining an inner bore for passage of the viscous fluid, a pushing piston (21) engaged in the inner bore. According to the invention: the tubular structure is a single-piece metal tubular body (3) extending from the first end (4) to a second end (5) provided with a connector (7) for sealable fastening of a trans-tissue injection vector, the pushing piston (21) has a metal rod (22) having a straight transverse section that is constant over its entire length and complementary, while allowing for operational clearance, with that of the bore of the metal tubular body (3).

Abstract: Syringe assemblies for use in flush applications are provided. Syringe assemblies according to one aspect of the present invention include a plunger rod and a syringe barrel that incorporate one or more pulsing elements on the plunger rod or barrel that are rotatable to create pulsatile movement or continuous and unimpeded movement a plunger rod within a syringe barrel. One or more embodiments pertain to syringe assemblies permit both pulsatile movement of the plunger rod within the barrel and continuous and unimpeded movement of the plunger rod in the distal direction along substantially the entire length of the syringe barrel upon application of force to the plunger rod in only the distal direction. Methods of flushing a catheter are also provided.

Abstract: A drug delivery system is disclosed which may be a throwaway or reusable device for delivery at least one drug to a patient. Also described is a method for administering a drug using said device and a packaged drug for use with said device. The drug delivery device (10) comprises a housing (12), a means (14) for generating a force capable of pushing a drug (16) from a packaging (18) into a human or animal body, a means (20) for transmitting said force to push the drug (16) from the packaging (18) into the human and animal body, and a means (38, 42b) for triggering the device. Where the device is a single use drug delivery system, a packaged drug (100) forms an integral part of the device. The packaged drug comprises a region (102) allowing it to be slidably mounted to the drug delivery device (10).

Abstract: The present invention relates to an injection device (1) comprising: a body (3) receiving a product, having a needle (7) and a piston (5) attached to a piston rod (8) movable between a storage position and an end-of-injection position, a sleeve (6) for protecting the needle (7), movable between an initial position, where the needle (7) is uncovered, and a final position, where the needle (7) is covered, biasing means (26) for moving said sleeve (6) from its initial position to its final position, immobilization means (16, 31) for keeping said sleeve (6) in its initial position, characterized in that: said piston rod (8) comprises a first portion (9) and a second portion (10), said second portion (10) being able to switch between a locked position, in which said second portion (10) is fixed to said first portion (9) and an unlocked position, in which said second portion (10) is movable with respect to said first portion on a predetermined distance along the longitudinal axis of said piston rod (8).

Abstract: A bone graft material is provided comprising granules of synthetic bone material, at least some of which have a solid coating comprising a blood-clotting agent. A device for delivering bone-replacement material to a an area to be treated is also provided, the device comprising: a chamber for containing bone-replacement material, wherein the chamber is pre-loaded and/or pre-coated on an interior surface thereof with a blood-clotting agent; means for introducing bone-replacement material into the chamber to contact the blood-clotting agent; and a means for delivering the bone-substitute material from the chamber to the area to be treated.

Abstract: An apparatus that allows for separating and collecting a fraction of a sample. The apparatus, when used with a centrifuge, allows for the creation of at various fractions in the apparatus. A buoy system that may include a first buoy portion and a second buoy member operably interconnected may be used to form at least three fractions from a sample during a substantially single centrifugation process. Therefore, the separation of various fractions may be substantially quick and efficient. Also selected fractions from the sample can be applied to a patient, either alone or as part of a mixture.

Abstract: The invention relates to a gripping edge (1) for a syringe with: a sleeve (7) with a first opening (9) for attachment to a barrel (2) of the syringe and a second opening (10). The gripping edge (1) comprises a flange (8) that is attached to the sleeve (7) at a distance from the first opening (9). A large number of catches (11), which project radially toward the inside from the inside wall (21) of the sleeve (7), are provided to engage in a groove attached to an outside surface of the barrel (2) or projections (13) and to fasten the sleeve (7) and, over this, the gripping edge (1) to the barrel (2), whereby a considerable number of openings, in particular a considerable number of lengthwise openings (14) and/or a considerable number of transverse openings (15), are cut out in the sleeve (7). As a result, a locking of the gripping edge (1) to the barrel (2) in the case of lower assembly forces is possible, by which a bursting tendency of the barrel (2), in particular during assembly, is considerably reduced.

Abstract: A substance delivery device including a casing formed by a first casing portion for a substance reservoir including a piston, a piston rod movable in an advancing direction to move the piston toward an outlet of the reservoir to deliver the substance, a dosing element which performs a dosing movement relative to the casing and, together with the piston rod, performs a delivery movement in the advancing direction, a dosing member connected to the dosing element wherein the dosing member is movable generally transversely to the piston rod to enable the piston rod to be moved counter to the advancing direction, a resetting element movably connected to the first casing portion to perform dosing member and piston rod disengaging and engaging movements, and a cam gear coupling the resetting element to the dosing member, wherein the cam gear forms a guiding rail on which the dosing member is guided.

Abstract: A drug-injecting device with a traveling hypodermic or intramuscular needle. The drug-injecting device includes a syringe body which has a base and a top opening into a hollow interior. A membrane is attached across the base of the syringe body, hermetically sealing the reservoir of the syringe from the environment. A plunger is situated within the hollow interior of the syringe body, so that one end of the plunger projects outward through the top of the syringe body. A piston is attached to the other end of the plunger. The plunger is configured to travel back and forth within the hollow interior of the syringe body between a first position and a second position. A needle is attached to the piston so that the needle travels with the plunger when the plunger is moved between the first and second positions.

Abstract: Disclosed is an ambulatory therapeutic fluid delivery device (10). The device includes at least one housing (200) connectable to a cannula (250), the at least one housing retaining a reservoir (220) to hold the therapeutic fluid. The device also includes a mechanically powered pumping mechanism (150) to cause delivery of at least some of the fluid from the reservoir, and a power-transfer mechanism to transfer manually-delivered power provided by a user to mechanically actuate the pumping mechanism.

Abstract: An apparatus that allows for separating and collecting a fraction of a sample. The apparatus, when used with a centrifuge, allows for the creation of at least three fractions in the apparatus. It also provides for a new method of extracting the buffy coat phase from a whole blood sample and mesenchymal stem cells from bone reaming material. A buoy system that may include a first buoy portion and a second buoy member operably interconnected may be used to form at least three fractions from a sample during a substantially single centrifugation process. Therefore, the separation of various fractions may be substantially quick and efficient.

Abstract: An apparatus and method for delivering liquid within an orifice of an animal is disclosed. In an exemplary embodiment, the apparatus comprises a hollow syringe defining a vessel having an open end; a plunger, slidingly and sealingly disposed within the vessel; and a flexible delivery tube, having a first end sealingly coupled to the open end and a delivery end for dispensing the liquid proximate the orifice. A light source directing light to the delivery end of the flexible tube may also be included.

Abstract: An intra-articular pharmaceutical composition is used for the treatment and/or the prevention of acute or chronic osteoarticular diseases and acute or chronic osteoarticular symptoms especially osteoarthritis. The composition includes a possibly adequate pharmaceutical carrier or diluent, a glycosaminoglycan, a compound activating the alpha 2 adrenergic receptor, an anti-inflammatory agent and stem cells.

Abstract: An injection device (100), provided for injection with an injection syringe (50) into an organism (1), comprises a guide device (10) designed to receive the injection syringe (50), wherein an injection needle (51) and a syringe body (52) of the injection syringe (50) can be moved relative to the guide device (10), in an advance movement towards or in a withdrawal movement away from the organism (1), and an actuating device (20) to which the injection syringe (50) can be coupled and which is used to actuate the injection syringe (50) for injection of an injectable substance into the organism (1), wherein the actuating device (20) has an actuating element (21) which forms an abutment for a piston device (53) of the injection syringe (50) on the guide device (10), in such a way that, during the withdrawal movement, the piston device (53) executes a relative movement counter to the injection needle (51) and the syringe body (52).

Abstract: A gasket 7 used for a prefilled syringe 1 in which liquid 3 is filled, having a constriction 8 on its circumferential side face in contact with an inner surface of a syringe barrel 2 and having a bottom face 7c which is not in contact with the liquid 3 whose circumference is formed in a tapered shape.

Abstract: Injection apparatus having a pre-filled syringe provided with a safety needle assembly, and a sleeve open at one end for containing the syringe with the safety needle assembly projecting from the open end of the sleeve. A cap is fitted to the open end and is configured to receive the projecting part of the safety needle assembly. A seal secures the cap to the sleeve. Following breaking of the seal, the syringe is removed from the sleeve and the cap is removed from the safety needle assembly so permitting the syringe to perform an injection. Thereafter, the syringe is reinserted into the sleeve with the safety needle assembly nearer the closed end of the sleeve, an internal rib in the sleeve co-operating with the safety needle assembly to retain that assembly in the sleeve.

Abstract: A system for increasing rates at which fluids may be manually forced through injection/aspiration elements, such as catheters and needles, includes the injection/aspiration elements, as well as a syringe including a pair of crossed handles, one associated with the barrel of the syringe, the other associated with the plunger of the syringe, to provide a mechanical advantage. The system may include and injection/aspiration element of small (e.g., 0.052 inch or smaller) inner diameter and small outer diameter (e.g., 5 French or less). Such systems enable the use of a single hand to hold and operate a syringe in a variety or procedures, including angiography, angioplasty, discography, glue/cement injection, and a variety of aspiration procedures (e.g., biopsy, sampling, media removal, etc.).

Abstract: A device for the storage and delivery of a bone graft or other implantable material to a desired surgical site includes a storage portion that extends from a first end to a second end. The first end of the storage portion is adapted to have a bone graft or other implantable material transferred therethrough into the storage portion. The device also includes a delivery portion that extends from a first end to a second end. The first end of the delivery portion communicates with the second end of the storage portion to permit the movement of the bone graft or other implantable material therethrough. The second end of the delivery portion is adapted to be positioned at a desired surgical site. The device further includes a delivery mechanism that is provided within the storage portion and the delivery portion and is adapted to move the bone graft material from the storage portion through the delivery portion to a desired surgical site.

Abstract: Apparatus for sealing a puncture communicating with a blood vessel includes a porous carrier formed from lyophilized hydrogel or other material. The plug may include at least first and second hydrogel precursors and a pH adjusting agent carried by the porous carrier in an unreactive state prior to exposure to an aqueous physiological environment. Once exposed to bodily fluids, the carrier expands as the lyophilized material hydrates to enhance and facilitate rapid hemostasis of the puncture. When the plug is placed into the puncture, the natural wetting of the plug by bodily fluids (e.g., blood) causes the first and second precursors to react and cross-link into an adhesive or “sticky” hydrogel that aids in retaining the plug in place within the puncture.

Abstract: A syringe including a plunger rod assembly including a proximal portion a distal portion with a stopper for expelling fluids from the syringe and a breakable connection between the proximal portion and the distal portion is disclosed. An impulse reduction system, which may be an elastic element or braking surfaces, reduces the contact impulse imparted by the proximal portion upon the distal portion when the connection between the distal portion and proximal portion breaks is also disclosed.

Abstract: With the use of a selectable fluid path assembly, the recovery and cleaning of the liquid path line is possible. Selecting the primary use path permits a syringe assembly to be filled with fluid in a positive pressure supplied fluid system. When the secondary fluid path is selected, the fluid in the line can be reversed and with negative pressure pulled back through the line up to the pump motor and moved back into the bottle. With air following the liquid a bubble can be detected and stop the fluid reversal. With the use of a selectable fluid path assembly, the prevention of contamination of the remaining liquid in the bottle can be prevent through proper use of the fluid recovery system.

Abstract: The present invention provides for the transplantation of tissue from a donor site in a body to a recipient site. The device includes an outer chamber having an interior volume in which a perforated inner chamber can be placed. During the aspiration of tissue, a vacuum is formed in the interior volume of the outer chamber, to draw tissue from a cannula into the perforated inner chamber. The perforations are sized such that fat is collected within the inner chamber, while fluids and other materials are drawn through the perforations, away from the collected fat. For reinjection, the inner chamber can be removed from the outer chamber, and a sleeve positioned to cover the perforations and thereby form a syringe body that can be interconnected to a needle and plunger for reinjection of the collected fat.

Abstract: A dosage delivery device, for example a syringe type device, having a housing (2) defining a reservoir (4); a plunger (6) within the reservoir and movable to decrease the volume of the reservoir so as to discharge material in the reservoir via a discharge opening; and an operating mechanism for the plunger, wherein a closure member (12) seals the discharge opening, and is coupled to the plunger operating mechanism such that it exposes the opening when the mechanism is engaged. In this way, a single movement to prime the mechanism also removes the closure.

Abstract: A carpule and its method of manufacture, the carpule tubular body composed of a polypropylene or similar polymer, the tubular body being sealed at one end by a seal of a thermoplastic vulcanizate (TPV) or similar polymer, the seal having been injection molded in contact with the tubular body prior to full curing of the material composing the tubular body, such that a chemical fusion bond is created between the seal and the tubular body.

Abstract: A system in accordance with embodiments of the present invention includes a cannula interconnected to a washing reservoir by a flexible conduit. The washing reservoir has an outlet that is connected to the inlet of a tissue collection reservoir. Washed tissue can be removed from the washing reservoir by tipping or otherwise causing the outlet of the washing reservoir to be covered by washed tissue. Tissue collected in the tissue collection reservoir can be readied for injection into a body by removing an inner or filter chamber from an outer chamber and blocking holes in the body of the inner chamber to use the inner chamber as part of a syringe.

Abstract: Systems and methods of co-injecting a solid object and an amount of fluid into a patient's tissue includes separably coupled syringe and needle portions. The syringe portion includes a barrel, a plunger, and a pushrod for disposing the solid object that is capable of independent movement with respect to the plunger. The needle portion includes a hollow needle configured to allow both the object and the fluid to pass out of the needle and into the patient's tissue. The needle portion may include a housing located behind the needle that is configured to hold the solid object. Once the needle portion and the syringe portion are coupled together, the device is operated in accordance with methods of the present invention to effectively co-inject the patient with the object and the amount of fluid.

Abstract: An apparatus is disclosed that allows for separating and collecting a fraction of a sample. The apparatus, when used with a centrifuge, allows for the creation of at least three fractions in the apparatus. It also provides for a new method of extracting the buffy coat phase from a whole blood sample. A buoy system that may include a first buoy portion and a second buoy member operably interconnected may be used to form at least three fractions from a sample during a substantially single centrifugation process. Therefore, the separation of various fractions may be substantially quick and efficient.

Abstract: A system in accordance with embodiments of the present invention includes a cannula interconnected to a collection vessel by a flexible conduit. The collection vessel can comprise one or more syringe bodies. The syringe bodies are provided with tissue removed from a body using the cannula by a tissue transfer channel. As a result, multiple syringe bodies can be loaded with tissue, without requiring manual handling of that tissue. Alternatively or in addition, a collection bag can be provided for receiving tissue removed from a body using a cannula. The tissue collection bag can include a filter. A collection vessel comprising a collection bag can be used in combination with a collection vessel comprising one or more syringe bodies.

Abstract: A device (1) for medical use, of the prefilled ready-to-use syringe type, comprising a tubular body (2) comprising, at its distal end (4), a tip (5) to take a needle and, at its proximal end (12), a piston (3) able to slide inside the said tubular body (2), the said piston (3) being arranged in an initial position, with respect to the tubular body (2), defining an internal working volume (8) at least partially filled with a medicinal liquid (9), the piston (3) being connected to a rod (11) for actuating the said piston, characterized in that the tubular body (2) is provided, on its internal face (13), with a means (14) of detecting the movement of the piston (3), the said means (14) being situated between the initial position of the piston and the proximal end (12) of the tubular body (2). The present invention also relates to a method for manufacturing such a device.

Abstract: A drive and dosing module for an injection device, and an injection device including the module, wherein the module includes a dosing member which can be displaced into one of several dosing positions in relation to a drive member to set a product dose, wherein one of the dosing or drive members forms several dosing stops at axially different heights and rotational stops that are associated with the dosing stops and the other member forms at least one selection element, and wherein the drive member can be moved in relation to the dosing member until it reaches a trigger position in which the at least one selection element attains one of the dosing stops and, in said trigger position, the selection element and the rotational stops combine to lock the rotation of the dosing member in both directions.

Abstract: A method and apparatus for separation, concentration, and/or applying a biological or bio-engineered fluid. Generally, the fluid application device includes a sprayer body to enable the application of the fluid and a container adaptable to enable the separation of the fluid into at least a first component and a second component. The container is releasably coupled to the nozzle. The nozzle is adapted to withdraw at least one of the first component or the second component from the container after the fluid has been separated to apply the fluid to a selected site.

Abstract: A device which facilitates the absorption of nicotine in order to reduce the incidence of tobacco smoking is disclosed. The device includes a tube defining an interior space. The tube has a first end with an opening and a second end. An inhalable, flowable liquid or gel composition is disposed in the interior space of the tube. The composition may include water, at least one vitamin, a flavoring agent, and nicotine. The flavoring agent may include an intense sweetener such as sucralose, and a natural or artificial fruit flavor. A user inhales on the first end of the tube of the device as a substitute oral activity to tobacco smoking and thereby ingests a source of nicotine that reduces the withdrawal symptoms experienced when smoking is stopped.

Abstract: A rubber-made syringe piston with a film laminated on it includes a plurality of annular ridges of different outer diameters formed continuously and integrally on a sliding surface of a liquid-contacting, leading end portion of the piston. The annular ridges may preferably be different by from 0.01 to 0.2 mm from one to another in outer diameter.

Abstract: An ophthalmic injection device has a dispensing chamber housing, a plunger, an actuator for driving the plunger, a temperature control device, and a temperature release mechanism. The dispensing chamber housing has an inner surface and an outer surface. The inner surface partially defines a dispensing chamber for holding a quantity of a substance. The plunger is engaged with the inner surface of the dispensing chamber housing, is capable of sliding in the dispensing chamber housing, and is fluidly sealed to the inner surface of the dispensing chamber housing. The temperature control device at least partially surrounds the dispensing chamber housing and is capable of altering the temperature of the substance in the dispensing chamber. The temperature release mechanism is in a locked position when the substance is outside the proper temperature range and an unlocked position when the substance is in the proper temperature range.

Abstract: A device for ophthalmic treatments comprises a package (9) forming a housing chamber (9a) inside it, and a syringe (2) inserted in the housing chamber (9a) and filled with a sterile liquid, of the type which can be injected into an eyeball. The liquid (4) is selected from amongst the family of perfluorocarbons. There are also two methods for making the device (1).

Abstract: An injection device for hands-free, transdermal injection of a liquid medicament, configured for easy handling and for manipulation by the use of the hand or fingers of the medical technician The device includes a housing having a base for attachment of the housing to the skin of a patient, an injection needle, and a reservoir for containing a vaccine. The device also has a means for expressing the vaccine from the reservoir through the injection needle that includes a mechanical force means for storing potential energy and exerting a mechanical force, and a hydraulic force means for transmitting the mechanical force into a hydraulic force. The hydraulic force is exerted onto the vaccine in the reservoir, thereby pressurizing and passing the vaccine through the injection needle. The mechanical force means is typically a mechanical spring, and the hydraulic force means is typically a closed hydraulic circuit.

Abstract: A combination of a disposable, wearable, self-contained medicine dispensing device, a cylindrical medicine container 52 incorporating a piston and having an open distal end and a proximal end closed by a closure body 54 made of a material, preferably silicone, that can be perforated by a needle, and a catheter device 16 having adhesive means 26 for attaching the catheter device to the skin of a user of the combination, the dispensing device comprising a housing 34, 36 having a compartment for receiving the container and further a not shown piston rod for displacing the piston towards the closed proximal end and actuating means for displacing the piston rod, the catheter device comprising a sealing ring 56?for receiving the closure body, and the dispensing device and the catheter device comprising co-operating attachment means for attaching the dispensing device to the catheter device with the container received in the compartment with the piston rod abutting the piston and the closure body received in the sea

Abstract: An injection device for use with tissue of a mammalian body comprising a first tubular member and a second tubular member slidably disposed in the first tubular member. The first and second tubular members have respective proximal and distal extremities. The distal extremity of the second tubular member is provided with a needle that is extendable from the distal extremity of the first tubular member. The proximal extremity of the second tubular member is lockable relative to the proximal extremity of the first tubular member. The second tubular member has a column strength when locked within the first tubular member for limiting retraction of the second tubular member relative to the first tubular member during puncture of the tissue by the needle.

Abstract: A plunger tip for being located on a distal end of a syringe plunger and for sliding sealed engagement with an interior surface of a syringe barrel includes a core constructed of a generally rigid material. The core has a first end for being secured to the plunger, a second end and an endless sidewall between the first and second ends. An elastomeric sleeve at least partially surrounds the endless sidewall of the core.

Abstract: A device for administering an injectable product including an insertion mechanism for inserting an injection needle into a tissue, the insertion mechanism including a first pressure element, a delivery mechanism for delivering the product from a product container, the delivery mechanism including a second pressure element, and a trigger for triggering the insertion and delivery mechanisms, wherein, when triggered, the insertion mechanism is moved by the first pressure element in an insertion direction from an initial position to an insertion position and the delivery mechanism remains at rest relative to the insertion mechanism until the insertion position is reached.

Abstract: A needleless injection device with a lower part receiving the agent cartridge and an upper part providing the energy needed for injection. The upper part contains energy store units capable of elastic form-change. Rotating the lower part in relation to the upper part causes the lower part to move along the longitudinal axis toward the upper part, resulting in the tension state of the energy storage structural elements. Furthermore, the device has a lock maintaining the tension of the energy storage units and component to release the lock. Among the energy storage structural parts there is at least one start unit capable of storing at least 60% of the total discharge energy (pressure), with the reversible elastic distortion not exceeding 25% of the internal length of the agent cartridge. The device has separate structural components for stretching the start unit and limiting its relaxation.

Abstract: A drug loading apparatus has a dispensing chamber housing formed by a top housing part and a bottom housing part. The top housing part is separable from the bottom housing part. A plunger is located in the bottom housing part such that the plunger forms a first fluid seal with an inner wall of the bottom housing part. When the top housing part is coupled to the bottom housing part, a second fluid seal is formed.

Abstract: A syringe includes a sleeve fitted in a receiving hole of the front end of a syringe cylinder. A limiting element is axially extended from an inner periphery of a joint portion of a combining section and a tapered section of the sleeve. The limiting element includes a plurality of spaced roots from which larger-diameter circular projections, by which an opening is defined, are extendedly secured. The diameter of the opening is narrower than the intermediate and bottom section of a tenon. Therefore, a larger deformation space of the limiting element is obtained for the smooth insertion of a push rod into the sleeve.