Abstract: Injection devices comprising multiple sections, e.g., modular components, are disclosed. In some embodiments the injection system comprises an upper section comprising a compressed gas reservoir, and one or more lower sections, e.g., modular components, containing one or more compositions to be injected. Methods of making and using the injection devices are also disclosed.

Abstract: Thermochemical ablation techniques may provide ablation of bodily tissue using chemical reaction energy.

Abstract: A drug delivery presentation is disclosed herein. The drug delivery presentation includes a display for showing a concentration of at least two different types of drugs including a first drug and a second drug for a subject, and also for showing a coordinate system for a variable first drug concentration and a variable second drug concentration. The drug delivery presentation also includes an optimal therapy mixture area presented on a coordinate system comprising a first border section determining a minimum concentration mixture for the first drug and the second drug. The optimal therapy mixture area further comprising a second border section determining a maximum concentration mixture for the first drug and the second drug. An arrangement for a drug delivery presentation is also disclosed.

Abstract: The invention provides for a urinary monitoring device to monitor for the presence or absence of markers indicative of a urinary tract infection (UTI). The invention also provides for methods of using such a device.

Abstract: The invention relates to a medical bag which is intended for the infusion of a medicament by means of gravity. The inventive bag comprises: at least two compartments, namely a first compartment (1) containing a medicament in the form of a solution and a second compartment (2) containing a rinsing solution; and means for separating/communicating the compartments, which prevent the rinsing solution from automatically entering the medicament compartment except at the end of the infusion period. The rinsing solution ends the infusion, by rinsing the medicament bag and the infusion line, such as to prevent any risk of contamination or leakage of residual medicament from the bag or line.

Abstract: A dispensing assembly for two components including a double syringe, a mixer, and a transfer device interposed between the double syringe and the mixer. The transfer device (3) includes a transfer unit with a transfer tube having a mixer at one end and a coupling area with an inlet portion at the other end. The coupling area is provided with coupling means which cooperate with coupling means on the double syringe. At least around the coupling area of the transfer unit, a support is arranged which is attachable to the double syringe.

Abstract: Embodiments of a delivery device, a kit comprising the delivery device, and methods of using the same are presented. In one embodiment, the delivery device includes a syringe assembly defining two or more reservoirs each configured to hold a dispensable material. Additionally, the delivery device may include a delivery tip. The delivery tip may have an inlet, an outlet, a central flow-restricting portion, and one or more channels adjacent to the central flow-restricting portion that provide fluid communication between the inlet and the outlet, the one or more channels including a section that tapers inwardly toward the outlet. In one embodiment, the delivery device is configured such that if the two or more reservoirs hold dispensable material then the syringe assembly can be actuated to dispense the dispensable material from the two or more reservoirs substantially simultaneously into the inlet.

Abstract: A system for expressing two materials onto a selected site is disclosed. The system can include a syringe that is operable to maintain two separated materials substantially separate until a selected time. The system can further include a tip portion operable to direct the two materials, either mixed or unmixed, to a selected site. The materials can include tissue sealants, growth factors, or other appropriate materials to be directed to a selected site.

Abstract: An electronic controller is provided for controlling the evacuation of fluid from one or more fluid reservoirs. The controller includes a plurality of sensors that sense environmental factors and the controller adjusts the evacuation of fluid from the bladder(s) using information gathered by the sensors.

Abstract: Dispenser (1) for adhesive Newtonian fluid, comprising: a syringe (5) containing the adhesive fluid; a plunger (23) for pushing the adhesive fluid out of the outlet spout of the syringe (5); an inlet (27) for a propellant gas; means (28) for mixing the adhesive fluid coming out from the syringe (5) and the propellant gas coming from said inlet (27) in order to obtain a mixture deliverable by atomization on a surface, said means (28) for mixing being shaped in such a way that the mixing of the adhesive fluid and the propellant gas takes place in proximity to an open end (14a) of a cannula or catheter (14) of the dispenser (1).

Abstract: A liquid-powder drug prompt-mixing type automatic syringe includes an injecting assembly, a drug-mixing assembly and a shooting device. The injecting assembly includes an injecting outer sleeve, in which the mouth of a blocking ampoule is slidably socketed, a needle is coaxially connected to the blocking ampoule by a hub; the drug-mixing assembly includes a drug-mixing outer sleeve, in which a precharging pressure menstruum bottle by a drug-mixing needle bracket; the shooting device includes a shooting outer sleeve and a spring pushing rod mechanism slidably socketed in the shooting outer sleeve a movable joining mechanism allows the injecting assembly to alternatively connect the drug-mixing assembly and the shooting device respectively. A liquid drug automatic syringe includes said injecting assembly and the shooting device.

Abstract: A carrier matrix may be delivered to a target position within a patient in a minimally invasive manner by first cutting a collagen sponge sheet into a plurality of relatively small pieces. These pieces are sized so that, when wet, they are capable of flowing through a cannula and/or reduced-diameter syringe tip. The pieces are placed into a syringe and wetted, say with a morphogenic solution, and optionally mixed with a bulking material, which is similarly sized to fit through the cannula. The thoroughly mixed and wetted product forms a viscous aggregate which may then be injected into the patient at the target site.

Abstract: A mixing portion is provided between a medical fluid container connecting portion 5 to which an opening of a medical fluid container 100 for a sclerosing agent is to be connected and a gas container connecting portion 6 to which an opening of a gas container 200 for a gas is to be connected. The mixing portion has a communication passageway R for communication between the openings of the containers 100 and 200 connected to the connecting portions 5 and 6. The mixing portion is deformable such that relative positions of the connecting portions 5 and 6 can be changed.

Abstract: A diluent/medication mixing syringe assembly is described which includes a cannula which extends through a syringe plunger assembly into a reservoir of the syringe assembly. The cannula facilitates injection of a diluent, medication or other fluid into the fluid reservoir of the syringe assembly immediately prior to use for mixing with a medication in the reservoir. In one embodiment, a mixing element is secured to a distal end of the cannula within the reservoir to improve mixing efficiency.

Abstract: An apparatus for making and administering two non-homogenous liquids to target tissue includes a spray comprising two syringes for containing the first and second non-homogenous liquid where the syringes are adapted to be removably coupled to an applicator. The applicator includes a pair of elongated tubes each having a tubular sheath at a proximal end, a distal end and a lumen in which the pair of elongated tubes are disposed. The apparatus includes a regulator module having an inlet port adapted for connection to a source of gas under pressure and a gas outlet port adopted for connection to the gas inlet port of the sheet. A vent gas inlet port is adapted for connection to a vent port of an endoscopic cannula where the regulator vents a quantity of gas from the endoscopic cannula approximately equal to a quantity of gas introduced at the gas inlet port of the sheet.

Abstract: The present invention relates to a device for delivery of medicament comprising a main housing; a container arranged in said housing and arranged to be connected to a medicament delivery member, wherein said container includes at least two chambers and at least one longitudinally movable plunger and wherein at least one chamber contains a medicament agent; a pre-treating arrangement acting on said container; drive force means acting on a longitudinally movable plunger rod capable of exerting a force on said container; and activating delivery means acting a said drive force means for delivering medicament via said medicament delivery member characterised in that said pre-treating arrangement comprises clickable means for manually and delay intermittently mixing said medicament agent and for manually priming said container

Abstract: An injection device for holding and activating a two-chamber ampulla has components whose relative movement causes the pistons of the two-chamber ampulla to be moved in order to mix the substances, as well as devices for injecting the product which is mixed in this way. For this purpose, a receptacle (103) into which the two-chamber ampulla (111) can be inserted and secured is held in a housing (101), and the receptacle (103) can be displaced by means of a carriage (108). A tappet (104) which acts on the pistons (111A, 111B) is movably held in the receptacle (103). A traction cable (114) which is deflected by means of a roller (109) which is mounted on the carriage (108) and one of whose ends is connected to the receptacle (103) and the other end of which is connected to a tension spring (110) which is held on the housing (101) is provided in order to carry out a mixing stroke, insertion stroke, injection stroke and a return stroke.

Abstract: A device is provided that allows for treatment or pre-treatment of an area of a human or animal organ intended to be penetrated to connect the vascular system of said human or animal with a sampling, infusion, or withdrawal container. The device comprises nitric oxide (NO) for obtaining a vaso-dilating effect at said area during said treatment or pre-treatment.

Abstract: An adhesive composition for use in surgical therapy includes at least the following components a) and b): a) a liquid mixture including cyanoactrylate monomers and at least one plasticizer, where the proportion of the at least one plasticizer in component a) is greater than 10% by weight based on the total weight of component a), and b) an aqueous liquid including at least one compound from the group of borate salt, basic amino acid, gelatin and gelatin derivative.

Abstract: An apparatus and method for applying a beneficial agent to the skin is disclosed in one embodiment of the invention as including first and second chemical reactants, each being compatible with the skin. The first and second chemical reactants react with one another to generate a beneficial agent and enhance the permeability of the skin (e.g., by generating heat). The beneficial agent may then be applied to the skin while the permeability of the skin is enhanced. In selected embodiments, the first chemical reactant includes one or more metals, or alloys thereof, that are compatible (i.e., not harmful) with the skin. Similarly, in selected embodiments, the second chemical reactant may include water. In certain embodiments, the beneficial agent generated by the first and second chemical reactants includes an antioxidant such as hydrogen.

Abstract: Dispensing assemblies, methods, and kits of parts for dispensing two separate fluids to an treatment site, including entraining non-atomized flow of a first fluid in an atomized flow of a second fluid, delivering a first fluid upstream from a second fluid, delivering a first fluid and a second fluid with re-shapeable malleable tubes, delivering first and second fluids with releasable connectors maintained by a handle assembly, and kits of parts with angularly offset pockets.

Abstract: The invention includes a device having a chamber within a syringe. A fluid passageway extends through a syringe piston. A valve is associated with the passageway controlling fluid passage through the piston. The invention includes a piercing structure having a head segment and a body portion, with a channel through the body portion and through at least one surface of the head without passing through the tip. In another aspect the invention encompasses a method of preparing an agent for administration to an individual. A first component is provided within a syringe and a second component is provided within a vial. A closed valve is associated with a fluid passageway between the vial and the syringe barrel through a piston. Valve repositioning allows fluid passage and sliding of the piston joins the first and second components. Repeated sliding of the piston mixes the components to produce the medication agent.

Abstract: Convenience kits designed to provide for closed, but selectable liquid transfer from a vial to a variety of IV containers and medical syringes. In particular, a kit for fully enclosing a vial for safety in hazardous drug transfer is disclosed. Generally, the kits contain unitized parts wherever reasonable to limit makes and breaks. Further, pathway determining kits provide selectable pathways for purging connections wish flushing solution where makes and breaks are made between various fluid pathway involved parts such that, when disconnections are made, flush solution is resident at the exposed interface. Also disclosed is a 3-way valve as part of a closed, switchable pathway controlling subsystem by which pathways are selected for reconstituting dry medicine in a vial, displacing a measured dose of liquid from a vial, exchanging gas into the vial for displaced liquid, delivering the measured dose to an IV container.

Abstract: An injector for injecting a medicament into a patient. The injector includes a container defining a first chamber, which contains a fluid therein, and a second chamber. The injector also includes an injection conduit configured for directing the fluid fired from the container into the patient. A transfer mechanism is operable by a user to transfer the fluid from the first chamber to the second chamber in a first stage of operation, and a firing mechanism is operable by the user for firing the fluid from the second chamber through the injection conduit in a second stage of operation. An energy source is in powering association with the firing mechanism to drive firing mechanism in the first and second stages.

Abstract: An injectable material delivery device is disclosed and can include a barrel that can have an internal chamber. A plunger can be at least partially disposed within the internal chamber of the barrel. Further, a collapsible mixing blade can be disposed within the internal chamber.

Abstract: A syringe device and a method of preparing medicine using the device capable of easily and accurately performing operations for mixing and dissolving a lyophilized product into a dissolution liquid before use. A double ended needle assembly and an intermediate holder are fitted to the first cylindrical part of a connection holder, a first syringe in which the dissolution liquid is stored is inserted into the first cylindrical part through the intermediate holder, and a second syringe in which the lyophilized product is stored in a depressurized state is fixedly inserted into the second cylindrical part of the connection holder. First, the intermediate holder is locked by a finger hooking projected piece, the first syringe is pushed into the intermediate holder in the locked state of the double ended needle assembly at an initial position by locking ribs, and the first syringe is unsealed by one end of the double ended needle.

Abstract: A sprayer is capable of inhibiting or preventing clogging occurring in a nozzle upon ejection of a liquid through the nozzle. A sprayer includes liquid supply for separately supplying a first liquid and a second liquid different in liquid composition, and a nozzle. The nozzle includes a first flow path and a second flow path along which passes the first liquid and the second liquid supplied from the liquid supply. In addition, the nozzle includes a third flow path along which passes a gas. A merge part is provided at which the first flow path and the second flow path merge at their respective halfway parts. A vent is provided at the merge part for allowing the gas which has passed through the third flow path to flow into the merge part.

Abstract: A nasal spray apparatus for simultaneously administrating metered amounts of multiple medicaments includes chambers for separately storing incompatible medicaments, such as an antihistamine and a steroid. Reciprocal piston pumps allow the medications to be sprayed into the user's nasal cavity. Two pumps can be used to separately transfer the medicaments to a receptacle where they can be initially mixed just prior to administration. A small volume receptacle is used to reduce the amount of mixture remaining after each stroke of the nasal spray apparatus. A check valve can be associated with each pump to further reduce medicament mixtures from cross contamination within storage chamber preparations. Collapsible components, including collapsible storage chambers or balloon capacitors can be employed to compensate for vacuums and back pressures as the medicaments are pumped to a spray nozzle.

Abstract: The present disclosure describes a needle guard device or system that can be used with drugs requiring reconstitution. The needle guard is preferably a passive needle guard that can be used during reconstitution without activating the safety mechanism. Following administration of the medication, the needle guard shields a user from inadvertent needle sticks by extending a protective shield over the needle.

Abstract: A delivery system is provided for mixing and dispensing a plurality of components and a method for its use. The system includes a first assembly having first and second separate chambers capable of holding first and second components respectively, a second assembly having third and fourth separate chambers capable of holding third and fourth components respectively, and a coupling device for movably coupling the first and second assemblies such that the second assembly is movable relative to the first assembly between a first position wherein the first, second, third and fourth chambers remain isolated from one another, and a second position wherein at least the first and third, and second and fourth chambers are in communication with one another via at least one conduit therebetween.

Abstract: Certain embodiments include a surgical delivery system for a medical sealant including a packaging system with a detachable a sterile surface for mixing the sealant as needed for application.

Abstract: A pre-dosed, pre-packaged mixing system and associated method for mixing, storing, and dispensing a two-part dental composition that becomes less stable upon mixing. The mixing system includes a pre-dosed, pre-packaged quantity of a first component contained within a first chamber, and a pre-dosed, pre-packaged quantity of a second component contained within a second chamber. The chambers are separated by separation means so as to separate the two-components prior to mixing. Once mixed, the practitioner is able to record a mixing and/or expiration date on at least a portion of the mixing system so as to indicate a shelf-life of the less stable mixed dental composition.

Abstract: The present invention is directed to an assembled syringe for administering powder medicament in the field of medicine. By using a connecting tube, a solvent bottle containing diluent communicates with a solute bottle containing powder by external force, and the diluent is injected into the solute bottle through the connecting tube under pressure. After the powder is dissolved and mixed uniformly, the mixed solution is injected directly into a patient or added to a transfusion bottle or tube. Both the solvent and solute bottles are packaged into a sleeve to avoid contamination. Buckles on the plunger sleeve are fitted into restricting slots on the sleeve. The fitting of the slots and buckles restricts the position of the syringe, self-locking and controlling the magnitude of force by which the solute bottle is communicated with the solvent bottle, controlling the depth of insertion of the needle into the body, and preventing misoperation or damage during transport, fetching and using.

Abstract: A device and method for delivering a pharmaceutical composition. The device includes an electronically controllable jetting device in communication with a source of a pharmacologically active material and a solid or fluidic mixing medium for receiving the ejected pharmacologically active material and directing it toward an end use destination.

Abstract: A therapeutic compound, methods and applicators to prevent and treat focal tissular lesions and infections in mammals is made by the mixture of an antiseptic powder and an antiseptic liquid, wherein the compound may be employed for an “assisted integration” through the “bone socket arrangement” pre or post-implantation by medication in a patient, for preventing or curing by direct contact diseases within the mouth and also to treat skin inflammations, infections, aphthas, herpes simplex infections, ulcers, burns, and other externally illness, to promote healing and bone growth and to chemical debridement.

Abstract: A method of forming a soft tissue biopsy cavity marker may include steps of providing a radio-opaque element and a bio-compatible and bio-degradable polymer such as alginate and delivering the provided radio-opaque element and the provided polymer to a biopsy site, such as a breast biopsy site. A gelling initiator that includes divalent cations such as NaCl2 may then be provided and delivered to the biopsy site, causing the previously delivered polymer to gel and to form a soft tissue biopsy marker in situ (within the biopsy site).

Abstract: A device for mixing and delivering a mixture of fluids to a target site includes a tube for containing the mixture. A compressible auger for mixing the fluids is movably disposed within the tube, one end of the auger being free at the distal end of the tube. A plunger is also movable within the tube in communication with the other end of the auger. When the plunger is moved axially within the tube the auger also moves axially and the auger is compressed to dispense the fluid. The mixing and delivery device can be used with an apparatus for the arthroscopic delivery of a tissue repair material to a repair site. The apparatus includes a first sheath and a second sheath removably attached to the first sheath for delivering the tissue repair material to the repair site.

Abstract: Disposable ampoule for use in an aerosol generating device, comprising: a medicament container that contains a medicament and is formed of a container body (10) and a container bottom (11), and a predetermined break point (12) that at least partly surrounds the container bottom, characterised by a collar (15) that surrounds the predetermined break point (12) at its outside and extends the container body (10) over and beyond the container bottom (11).

Abstract: In some arrangements, a pump for moving a fluid has one or more pump chambers and one or more flow control valves with diaphragm actuation regions. Motive fluid can activate the diaphragm actuation regions, and a pattern of fluid flow can be controlled by varying the pressure levels of the motive fluid.

Abstract: An injection device is disclosed which is designed to receive therein a two-compartment syringe, and to be used to mix the pharmaceutical agents and then conduct injections. The injection device comprises a cylindrical barrel portion so configured that the two-compartment syringe can be inserted therein in a rear-end first manner, a piston rod for pushing the slidable rear wall to advance, a front spring that is compressed, when the two-compartment syringe is inserted, and then push back the piston rod in the forward direction, and a sleeve which can be shifted back and forth and is provided by screw engagement with the outer surface of the rear part of the barrel portion to block the forward movement of the piston rod.

Abstract: The present invention is directed to an automatic reconstitution drug delivery device. The inventive device effects simple and automatic reconstitution of a dry drug. To effect reconstitution, a user displaces a release button which causes first and second chambers of a drug cartridge to communicate, resulting in automatic mixing of a diluent and dry drug to effect reconstitution of the dry drug. The user then simply sets the dose volume using a dose-setting mechanism, and administers the injection in a manner typical of self-injection drug delivery devices. Whole or partial automatic priming can be also achieved by the device.

Abstract: A transfer system (100, 100?, 100?) adapted to allow first contents of a first container (20) and second contents of a second container (30) to mix to form a material. The mixed material is retrieved to a syringe (40). The transfer system (100, 100?, 100?) comprises first (17) and second (18) flow control members for controlling fluid flow between the containers (20, 30) and the syringe (40). The invention further relates to a drug mixing kit comprising a container unit containing first and second containers, and a transfer unit comprising ports for receiving the containers and a syringe and a number of flow channels. The container unit and the transfer unit are adapted to be coupled together to form a drug mixing kit.

Abstract: A syringe device having a syringe barrel and a syringe piston having a container housing. At least a portion of the container housing is insertable within an internal chamber of the syringe barrel. A fluid passageway extends from the container housing through a piston stem. A method of protecting a syringe handler including providing the components of a syringe device and encasing the components in a protective film. The protective film is loose to allow manipulation of the syringe components relative to one another without opening or puncturing the film. Protective syringe device packaging that includes a laminate film of material sealed to encase the components of a syringe device containing a potentially harmful agent.

Abstract: Disclosed is an applicator device (10) for applying a multi-component fluid, especially a multi-component tissue glue, comprising a plurality of substantially cylindrical supply containers (12) for respectively one component of the fluid to be applied, each supply container (12) having a front end (16) with an outlet opening (18), a rear end (22) opposite to the front end (16), and a slidably displaceable piston (24) arranged within the supply container (12) and having a piston rod (26) extending out of the rear end (22) for operating the piston (24). Moreover, the applicator device includes a manifold (72) having terminal ends (50,58) with a first port for fluid connection with the front ends (16) of the supply containers (12), the manifold (72) further having internal channels (62) extending from the first ports of the terminal ends (50,58) to an outlet site.

Abstract: An apparatus for securing a neuromodulation lead to nervous tissue or surrounding tissue (i.e. meninges) is provided. The neuromodulation lead includes an elongated member having a proximal end, a distal end, and a passage extending there between. The lead further includes at least one electrical contact secured around an outer surface of the distal end of the elongated member for stimulating nervous tissue. The apparatus comprises first and second tubular members are disposed within the passage of the elongated member. Each of the tubular members terminates at the distal end of the elongated member. First and second glue components are provided for injecting into the first and second tubular members, respectively. The first and second glue components, when injected, exit the respective tubular members at the distal end of the elongated member and mix to create a solidified glue that anchors the distal end of the elongated member within the nervous tissue.

Abstract: A device for dispensing a multicomponent composition composed of a mixture of different fluid components includes a first and at least a second fluid component inlet. The device also includes a mixing area located downstream from the fluid component inlets and an outlet extending from the mixing area. Each of the fluid component inlets is adapted to communicate with a source of a different fluid component. The mixing area is adapted to receive a flow of a first and at least second fluid component. Within the mixing area, the flow of the first fluid component is disrupted to allow mixing with the flow of a second fluid component to form a flow of multicomponent composition. The mixing area is further adapted to disrupt the flow of the multicomponent composition before the flow of the multicomponent composition exits through the outlet.

Abstract: This description relates to drug delivery devices (100), as well as related components, systems and methods.

Abstract: This invention pertains to a hose system for an injector for injecting contrast agents and saline solution into the human body. The hose system comprises a contrast agent conduit (106, 126; 206, 226; 306, 326; 401, 402,403, 404, 405, 421, 422, 423, 424, 425; 501, 502, 503, 504, 521, 522, 523, 524), a saline solution conduit (116, 216, 316, 411, 412, 413, 414, 415; 511, 512, 513, 515) a pump hose (132; 232; 332; 432; 532) and a frame (135; 235; 335; 435, 436; 535, 536, 537). The contrast agent and saline solution conduits are mechanically fixed at a least one position to the frame. The pump hose is fixed to the frame at least two positions. The invention further pertains to a squeeze valve and a pressure measuring interface.

Abstract: A microcatheter having a distal end with a tip relief region comprising at least one spiral cut, preferably a full thickness cut, and preferably having decreasing pitch towards the distal tip. The microcatheter is preferably made of medical grade superelastic nitinol. The microcatheter can be used alone or as one catheter in a dual lumen microcatheter assembly.

Abstract: A dual syringe adapter for attachment to a pair of side-by-side syringes includes three interconnected portions. A first portion is configured so as to snap onto a plunger head portion of each syringe so as to connect the pair of syringes and maintain plunger movement in unison. A second portion of the adapter is configured so as to snap onto a syringe body of each syringe to help maintain the connection of the two syringes. The third interconnected portion is positioned between the first and second portions and when connected prevents relative movement of the plungers into the syringe bodies. Weakened sections allow the connecting portion to be severed from the first and second portions thereby allowing plunger movement into the syringe bodies. Once severed, the connecting portion is secured to syringe tips for dispensing a mixed composition.