The Lactone Ring Is Five-membered Patents (Class 549/295)
  • Patent number: 7763741
    Abstract: The subject invention provides a method for separating a terpene trilactone from Ginkgo biloba plant material or from an extract of Ginkgo biloba comprising a mixture of terpene trilactones, the process comprising the steps of: a) subjecting the Ginkgo biloba plant material or the extract to column chromatography with an appropriate solvent system to produce at least a first fraction containing the terpene trilactone bilobalide, a second fraction eluted after the first fraction containing the terpene trilactones GA and GB, and a third fraction eluted after the second fraction containing at least a preponderance of the terpene trilactones GC and GJ; and b) alkylating the terpene trilactone GB of the second fraction so as to produce a first mixture including terpene trilactone GA and alkylated terpene trilactone GB; or alkylating the terpene trilactone GC of the third fraction so as produce a second mixture including terpene trilactone GJ and alkylated terpene trilactone GC, so as to thereby isolate a terpen
    Type: Grant
    Filed: November 9, 2004
    Date of Patent: July 27, 2010
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Koji Nakanishi, Stanislav Jaracz, Shahid Malik, Hideki Ishii, Sergei V. Dzyuba
  • Patent number: 7759044
    Abstract: A dissolution modification agent suitable for use in a photoresist composition including a polymer, a photoacid generator and casting solvent. The dissolution modification agent is insoluble in aqueous alkaline developer and inhibits dissolution of the polymer in the developer until acid is generated by the photoacid generator being exposed to actinic radiation, whereupon the dissolution modifying agent, at a suitable temperature, becomes soluble in the developer and allows the polymer to dissolve in the developer. The DMAs are glucosides, cholates, citrates and adamantanedicarboxylates protected with acid-labile ethoxyethyl, tetrahydrofuranyl, and angelicalactonyl groups.
    Type: Grant
    Filed: January 25, 2008
    Date of Patent: July 20, 2010
    Assignee: International Business Machines Corporation
    Inventors: Robert David Allen, Phillip Joe Brock, Richard Anthony DiPietro, Ratnam Sooriyakumaran, Hoa D. Truong
  • Patent number: 7749679
    Abstract: A photosensitive composition containing a compound having a specific structure, a pattern-forming method using the photosensitive composition, and a compound having a specific structure used in the photosensitive composition.
    Type: Grant
    Filed: December 21, 2006
    Date of Patent: July 6, 2010
    Assignee: FUJIFILM Corporation
    Inventors: Kenji Wada, Kunihiko Kodama
  • Publication number: 20100130754
    Abstract: The present invention relates to the field of catalytic hydrogenation and, more particularly, to the use of Ru complexes with bidentate ligands, having one amino or imino coordinating group and one phosphino coordinating group, in hydrogenation processes for the reduction of esters or lactones into the corresponding alcohol or diol respectively.
    Type: Application
    Filed: January 27, 2010
    Publication date: May 27, 2010
    Inventors: Lionel Saudan, Philippe Dupau, Jean-Jacques Riedhauser, Patrick Wyss
  • Publication number: 20100121080
    Abstract: Disclosed are catalytic compositions having from about 35% to about 75% of Cu by weight, from about 15% to about 35% of Al by weight, and about 5% to about 20% of Mn by weight. The catalytic compositions are bulk homogeneous compositions formed from extruding and calcinating a powder formed from a precipitation reaction of Cu(NO3)2, Mn(NO3)2, Na2Al2O3. The catalytic compositions have one or more crystalline phases of one or more of CuO and CuxMn(3-x)O4, where x is from about 1 to about 1.5, or both. The catalytic compositions are useful for the conversion of 1,4-butane-di-ol to ?-butyrolactone by a dehydrogenation reaction.
    Type: Application
    Filed: April 15, 2009
    Publication date: May 13, 2010
    Applicant: BASF CATALYSTS LLC
    Inventor: Jianping Chen
  • Patent number: 7683187
    Abstract: The present invention relates to a process for preparing a lactone. The process comprises the steps of reacting an aldehyde with an organic halide in a carbon chain extension reaction to form an alcohol compound comprising a functional group capable of allowing for carbonylation of said alcohol compound, and then reacting said alcohol compound in a carbonylation reaction to form an hydroxycarboxylic acid; and cyclizing the hydroxycarboxylic acid to produce the lactone.
    Type: Grant
    Filed: April 20, 2007
    Date of Patent: March 23, 2010
    Assignee: Danisco A/S
    Inventors: Lars Wiebe, Thomas Schmidt
  • Publication number: 20100050719
    Abstract: The present invention concerns the field of bacterial biocontrol. More precisely, the invention relates to the identification of chemicals which promote the growth of bacteria inactivating NAHL, such as gamma-caprolactone (GCL) and 4-heptanolide (HTN) and their use in soil additives.
    Type: Application
    Filed: January 18, 2008
    Publication date: March 4, 2010
    Inventors: Denis Faure, Amélie Cirou, Yves Dessaux
  • Patent number: 7666866
    Abstract: This application relates to a compound of formula (I) (or a pharmaceutically acceptable salt of the compound) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa and/or thrombin, as well as a process for its preparation and intermediates therefor.
    Type: Grant
    Filed: November 15, 2005
    Date of Patent: February 23, 2010
    Assignee: Eli Lilly and Company
    Inventors: Jeffry Bernard Franciskovich, David Kent Herron, Valentine Joseph Klimkowski, Angela Lynn Marquart, John Joseph Masters, David Mendel, Andrew Michael Ratz, Gerald Floyd Smith, Michael Robert Wiley, Ying Kwong Yee
  • Publication number: 20100035948
    Abstract: The present invention provides a compound of formula I and a compound of formula II, methods of use and formulations thereof.
    Type: Application
    Filed: October 8, 2007
    Publication date: February 11, 2010
    Inventors: Naresh Kumar, George Iskander
  • Publication number: 20090305239
    Abstract: A method of determining a level of biologically active PON enzyme is provided. The method comprising determining lactonase activity of the PON enzyme, the lactonase activity being indicative of the level of biologically active PON enzyme. Also provided are novel compounds which may be used for measuring a lactonase activity of an enzyme.
    Type: Application
    Filed: August 14, 2006
    Publication date: December 10, 2009
    Inventors: Dan S. Tawfik, Olga Khersonsky
  • Patent number: 7579485
    Abstract: A method for producing lactones, which comprises reacting an amide compound of Formula (I): [wherein X represents a halogen atom; R, R? and R1 to R6 each independently represents a hydrogen atom or any desired substituent; and n represents an integer of 0 to 2] with an aqueous medium.
    Type: Grant
    Filed: February 3, 2003
    Date of Patent: August 25, 2009
    Assignee: Mitsubishi Rayon Co., Ltd.
    Inventors: Makoto Kaneko, Yasuhiro Ninomiya, Tetsuji Nakamura, Eiji Satou
  • Publication number: 20090198065
    Abstract: To provide a resist polymer comprising, as a structural unit, an acid-decomposable unit having a structure represented by formula (1) or (2) which exhibits a small line edge roughness and produces little defects in DUV excimer laser lithography or the like.
    Type: Application
    Filed: March 26, 2009
    Publication date: August 6, 2009
    Applicant: Mitsubishi Rayon Co., Ltd.
    Inventors: Hikaru Momose, Atsushi Ootake, Tadashi Nakamura, Akifumi Ueda
  • Patent number: 7498450
    Abstract: A homogeneous process for the hydrogenation of dicarboxylic acids and/or anhydrides in the presence of a catalyst comprising: (a) ruthenium, rhodium, iron, osmium or palladium; and (b) an organic phosphine; wherein the hydrogenation is carried out in the presence of at least about 1% by weight water and wherein the reaction is carried out at a pressure of from about 500 psig to about 2000 psig and a temperature of from about 200° C. to about 300° C. such that from about 1 mol to about 10 mol of hydrogen are used to strip 1 mole of product from the reactor.
    Type: Grant
    Filed: October 15, 2004
    Date of Patent: March 3, 2009
    Assignee: Davy Process Technology Limited
    Inventors: Michael Anthony Wood, Simon Peter Crabtree, Derek Vincent Tyers
  • Publication number: 20090030213
    Abstract: A method for modifying ethylenic unsaturation in a triglyceride. One or more unsaturated fatty acyl moieties present in the triglyceride are substituted with a lactone or ketone moiety via a electron donor mediated reaction. The resulting reaction products are useful, for example, as formulations for lubricants, hydraulic fluids, dielectric fluids, and intermediates for polymer synthesis.
    Type: Application
    Filed: September 29, 2008
    Publication date: January 29, 2009
    Applicant: BUNGE OILS, INC.
    Inventors: Neil Wallace Higgins, Jerry F. Stults
  • Patent number: 7459571
    Abstract: Catalyst in the form of an extrudate which comprises from 5 to 85% by weight of copper oxide and in which the same oxidic support material is present in the active composition and as binder, and the use of the catalyst for the hydrogenation of carbonyl compounds.
    Type: Grant
    Filed: November 2, 2007
    Date of Patent: December 2, 2008
    Assignee: BASF Aktiengesellschaft
    Inventors: Stephan Schlitter, Olga Schubert, Michael Hesse, Sabine Borchers, Markus Roesch, Rolf Pinkos, Alexander Weck, Gunther Windecker
  • Patent number: 7442810
    Abstract: A process for variably preparing mixtures of optionally alkyl-substituted BDO, GBL and THF by two-stage hydrogenation in the gas phase of C4 dicarboxylic acids and/or derivatives thereof, which comprises a) hydrogenating in a gas phase a gas stream of C4 dicarboxylic acids and/or derivatives thereof over a particular catalyst at a particular pressure and temperature to give a stream mainly containing of optionally alkyl-substituted GBL and THF, b) removing any succinct anhydride, c) converting the products remaining predominantly in the gas phase in the partial condensation, THF, water and GBL to give a stream comprising a mixture of BDO, GBL and THF, d) removing the hydrogen from the products and recycling it into the hydrogenation, e) distillatively separating the products, THF, BDO, GBL and water, if appropriate recycling a GBL-rich stream or if appropriate discharging it, and working up BDO, THF and GBL distillatively, and setting the ratio of the products, THF, GBL and BDO, relative to one another wi
    Type: Grant
    Filed: December 4, 2004
    Date of Patent: October 28, 2008
    Assignee: BASF Aktiengesellschaft
    Inventors: Markus Roesch, Rolf Pinkos, Michael Hesse, Stephan Schlitter, Henrik Junicke, Olga Schubert, Alexander Weck, Gunther Windecker
  • Patent number: 7427684
    Abstract: A homogeneous process for the hydrogenation of dicarboxylic acid and/or derivative thereof with an amine in the presence of a catalyst comprising: (a) ruthenium or osmium; and (b) an organic phosphine; and wherein the hydrogenation is carried out in the presence of water.
    Type: Grant
    Filed: October 15, 2004
    Date of Patent: September 23, 2008
    Assignee: Davy Process Technology Limited
    Inventors: Simon Peter Crabtree, Derek Vincent Tyers, Mohammed Sharif
  • Publication number: 20080227984
    Abstract: This invention relates to the selective oxidation of organic compounds. According to the invention organic compounds are selectively oxidized using a peracid or a source of peracid, a transition metal based heterogeneous catalysts and a borate or boric acid in the presence of water. Using the process of the present invention, both excellent conversion and product selectivity maybe obtained.
    Type: Application
    Filed: October 21, 2005
    Publication date: September 18, 2008
    Applicant: U.S. Borax, Inc.
    Inventors: Michael John Greenhill-Hooper, Robert Raja, John Meurig-Thomas
  • Patent number: 7414145
    Abstract: A method of an enantioselective nucleophilic addition reaction to carbonyl, which enables an asymmetric synthesis of an optically active ?-hydroxy-?-keto acid ester, an optically active ?-hydroxy-?-amino acid ester, hydroxydiketone compounds, etc. being useful as a raw material or synthesis intermediate for producing a pharmaceutical preparation, an agricultural chemical, a fragrance, a functional polymer or the like. In this method, the nucleophilic addition reaction of enamide compound accompanied by hydroxyl (—OH) formation to carbonyl is carried out in the presence of a chiral catalyst with copper or nickel.
    Type: Grant
    Filed: January 24, 2005
    Date of Patent: August 19, 2008
    Assignee: Japan Science and Technology Agency
    Inventor: Shu Kobayashi
  • Patent number: 7414139
    Abstract: The invention provides small molecules that act as catalytic antioxidants and methods of use thereof. The compounds can repeatedly bind and destroy reactive oxygen species by serving as substates for enzymes of the methionine sulfoxide reductase (Msr) class. Some embodiments of the catalytic antioxidant compounds are derived from drugs with anti-inflammatory activity due to inhibition of cyclooxygenase enzymes.
    Type: Grant
    Filed: August 29, 2006
    Date of Patent: August 19, 2008
    Assignees: Florida Atlantic University, Hosptial for Special Surgery
    Inventors: Herbert Weissbach, Nathan Brot
  • Publication number: 20080125345
    Abstract: The invention relates to a gamma-undecenolactone of formula (I), wherein a lactonic cycle can carry an unsaturation between carbon No2 and carbon No3 and is preferably saturated, RI is a possibly substituted C7 alkenyl or alkynyl group comprising at least one unsaturation, and preferably RI is an CH2?CH—CH2—CH2—CH2—CH2—CH2 group, said gamma-undecenolactone contains an asymmetric carbon in position 4 having (R) or (S) configuration. The biosynthesis of said gamma-undecenolactone and the use thereon for perfumery and for a food flavouring agent are also disclosed.
    Type: Application
    Filed: November 2, 2005
    Publication date: May 29, 2008
    Applicant: V. Mane Fils
    Inventors: Joseph Zucca, Jean Mane
  • Patent number: 7341818
    Abstract: The disclosed invention relates to novel norborne-type monomers containing pendent lactone or sultone groups. The invention also relates to norborne-type polymers and copolymers containing pendent lactone or sultone groups. These polymers and copolymers are useful in making photoimagable materials. The photoimagable materials are particularly suitable for use in photoresist compositions useful in 193 and 157 nm photolithography.
    Type: Grant
    Filed: January 10, 2005
    Date of Patent: March 11, 2008
    Assignee: Promerus LLC
    Inventors: Xiaoming Wu, Larry F. Rhodes, Lawrence Seger
  • Patent number: 7329766
    Abstract: The present invention relates to a process for preparing stereoisomerically enriched 4-aryl-4-hydroxybutanoic acid derivatives by reducing 4-aryl-4-ketobutanoic acid derivatives in the presence of ruthenium-containing catalysts.
    Type: Grant
    Filed: June 15, 2005
    Date of Patent: February 12, 2008
    Assignee: Lanxess Deutschland GmbH
    Inventors: Hans-Christian Militzer, Boris Bosch, Markus Eckert, Benjamin Meseguer
  • Patent number: 7316884
    Abstract: A 5-methylene-1,3-dioxolan-4-one derivative and a monomer and copolymer thereof and a resist composition containing the polymer or copolymer where the 5-methylene-1,3 -dioxolan-4-one derivative is of formula (1): wherein R1 represents a bridged cyclic hydrocarbon group containing 4 to 16 carbon atoms, or a linear or branched alkyl group containing 1 to 6 carbon atoms which has a bridged cyclic hydrocarbon group containing 4 to 16 carbon atoms as a substituent; R2 represents a hydrogen atom, or a linear or branched alkyl group containing 1 to 6 carbon atoms; or R1 and R2 represent a bridged cyclic hydrocarbon group containing 4 to 16 carbon atoms together with the carbon atom to which they are bound, provided that the alkyl group and the bridged cyclic hydrocarbon group may have at least one substituent selected from a group consisting of a linear or branched alkyl group containing 1 to 6 carbon atoms which may be optionally substituted, a hydroxy group, a carboxy group, an acyl group containing 2 to 6 car
    Type: Grant
    Filed: October 22, 2002
    Date of Patent: January 8, 2008
    Assignee: Mitsubishi Rayon Co., Ltd.
    Inventors: Ryuichi Ansai, Yoshihiro Kamon, Tadayuki Fujiwara, Hideaki Kuwano, Atsushi Ootake, Hikaru Momose
  • Patent number: 7314942
    Abstract: Alpha-methylenelactone is produced from butyrolactone and valerolactone by the addition of formaldehyde in a supercritical fluid.
    Type: Grant
    Filed: January 7, 2003
    Date of Patent: January 1, 2008
    Assignee: E. I. duPont de Nemours & Co.
    Inventors: Keith W. Hutchenson, Leo E. Manzer
  • Patent number: 7297714
    Abstract: The present invention provides compounds, compositions and methods for the selective inhibition of cathepsin S. In a preferred aspect, cathepsin S is selectively inhibited in the presence of at least one other cathepsin isozyme. The present invention also provides methods for treating a disease state in a subject by selectively inhibiting cathepsin S.
    Type: Grant
    Filed: October 20, 2004
    Date of Patent: November 20, 2007
    Assignee: IRM LLC
    Inventors: Hong Liu, Phillip Alper, Daniel Mutnick, Donald Karanewsky
  • Publication number: 20070213524
    Abstract: Heterocycles, e.g., epoxides, are carbonylated at low pressure with high percentage conversion to cyclic, ring expanded products using the catalyst where L is tetrahydrofuran (THF).
    Type: Application
    Filed: February 13, 2007
    Publication date: September 13, 2007
    Applicant: Cornell Research Foundation, Inc.
    Inventors: Geoffrey W. Coates, John Kramer
  • Patent number: 7205416
    Abstract: Process for converting certain lactones to their alpha-methylene substituted forms that exhibits high conversion and selectivity.
    Type: Grant
    Filed: June 28, 2005
    Date of Patent: April 17, 2007
    Assignee: E. I. du Pont de Nemours and Company
    Inventors: Keith W. Hutchenson, Kostantinos Kourtakis, Leo Ernest Manzer
  • Patent number: 7199254
    Abstract: Process for converting certain lactones to their alpha-methylene derivatives in the liquid phase with both high conversion and selectivity using easily recoverable novel heterogeneous catalysts.
    Type: Grant
    Filed: June 28, 2005
    Date of Patent: April 3, 2007
    Assignee: E. I. du Pont de Nemours and Company
    Inventors: Keith W. Hutchenson, Kostantinos Kourtakis, Leo Ernest Manzer
  • Patent number: 7186495
    Abstract: There are here disclosed a photoresist material for lithography using a light of 220 nm or less which comprises at least a polymer represented by the following formula (2) and a photo-acid generator for generating an acid by exposure: wherein R1, R2, R3 and R5 are each a hydrogen atom or a methyl group; R4 is an acid-labile group, an alicyclic hydrocarbon group having 7 to 13 carbon atoms, which has an acid labile group, an alicyclic hydrocarbon group having 7 to 13 carbon atoms, which has a carboxyl group, or a hydrocarbon group having 3 to 13 carbon atoms, which has an epoxy group; R6 is a hydrogen atom, a hydrocarbon group having 1 to 12 carbon atoms, or an alicyclic hydrocarbon group having 7 to 13 carbon atoms, which has a carboxyl group; x, y and z are optional values which meet x+y+z=1, 0<x?1, 0?y<1 and 0?z<1; and a weight-average molecular weight of the polymer is in the range of 2000 to 200000, and a resin having a (meth)acrylate unit of an alicyclic lactone structure represented by the
    Type: Grant
    Filed: December 29, 2000
    Date of Patent: March 6, 2007
    Assignee: NEC Corporation
    Inventors: Katsumi Maeda, Shigeyuki Iwasa, Kaichiro Nakano, Etsuo Hasegawa
  • Patent number: 7183421
    Abstract: The present invention provides a process for producing an oxide from an alcohol compound, the process comprising the steps of causing silica gel to carry the alcohol compound thereon and an oxidative catalyst thereon, and oxidizing the alcohol compound in the presence of an oxidizing agent, giving an oxide higher in oxidizing degree than the alcohol compound, and also provides a process for producing an oxide from an alcohol compound, the process comprising the steps of causing silica gel to carry the alcohol compound, and subjecting the alcohol compound to an electrolytic oxidation, giving an oxide higher in oxidizing degree than the alcohol compound.
    Type: Grant
    Filed: August 11, 2004
    Date of Patent: February 27, 2007
    Assignee: Otsuka Kagaku Kabushiki Kaisha
    Inventors: Hideo Tanaka, Yutaka Kameyama
  • Patent number: 7166727
    Abstract: Process for converting certain lactones to their alpha-methylene substituted forms in a supercritical or near-critical fluid phase reaction using a novel grafted catalyst that not only exhibits high initial activity (conversion), but also maintains a high level of activity with time on stream.
    Type: Grant
    Filed: June 28, 2005
    Date of Patent: January 23, 2007
    Assignee: E. I. du Pont de Nemours and Company
    Inventors: Keith W. Hutchenson, Kostantinos Kourtakis, Leo Ernest Manzer
  • Patent number: 7164032
    Abstract: Process for converting certain lactones to their alpha-methylene substituted forms that not only exhibits high initial activity (conversion), but also provides high reactor productivity (mass of product per mass of catalyst per unit of time) and sustained maintenance of a high level of activity and productivity with time on stream.
    Type: Grant
    Filed: June 28, 2005
    Date of Patent: January 16, 2007
    Assignee: E. I. du Pont de Nemours and Company
    Inventors: Keith W. Hutchenson, Kostantinos Kourtakis, Leo Ernest Manzer
  • Patent number: 7164033
    Abstract: Process for converting certain lactones to their alpha-methylene substituted forms that not only exhibits high initial activity (conversion), but also maintains a high level of activity with time on stream.
    Type: Grant
    Filed: June 28, 2005
    Date of Patent: January 16, 2007
    Assignee: E. I. du Pont de Nemours and Company
    Inventors: Keith W. Hutchenson, Kostantinos Kourtakis, Leo Ernst Manzer
  • Patent number: 7161014
    Abstract: Process for converting certain lactones to their alpha-methylene substituted forms that not only exhibits high initial activity (conversion), but also maintains a high level of activity with time on stream.
    Type: Grant
    Filed: June 28, 2005
    Date of Patent: January 9, 2007
    Assignee: E. I. du Pont de Nemours and Company
    Inventors: Keith W. Hutchenson, Kostantinos Kourtakis, Leo Ernest Manzer
  • Patent number: 7153981
    Abstract: Process for converting certain lactones to their alpha-methylene substituted forms in a supercritical or near-critical fluid phase reaction using an oxynitride catalyst or a composite oxynitride catalyst incorporating lithium, sodium, potassium, rubidium, cesium, magnesium, calcium, strontium, or barium or combinations thereof.
    Type: Grant
    Filed: June 28, 2005
    Date of Patent: December 26, 2006
    Assignee: E. I. du Pont de Nemours and Company
    Inventors: Keith W. Hutchenson, Kostantinos Kourtakis, Leo Ernest Manzer
  • Patent number: 7151185
    Abstract: Process for converting certain lactones to their alpha-methylene substituted forms using an oxynitride catalyst or a composite oxynitride catalyst incorporating lithium, sodium, potassium, rubidium, cesium, magnesium, calcium, strontium, or barium or combinations thereof.
    Type: Grant
    Filed: June 28, 2005
    Date of Patent: December 19, 2006
    Assignee: E. I. du Pont de Nemours and Company
    Inventors: Keith W. Hutchenson, Kostantinos Kourtakis, Leo Ernest Manzer
  • Patent number: 7141682
    Abstract: Process for converting certain lactones to their alpha-methylene derivatives in the liquid phase using oxynitride catalysts or composite catalysts incorporating dithium, sodium, potassium, rubidium, cesium, magnesium, calcium, strontium, or barium or combinations thereof.
    Type: Grant
    Filed: June 28, 2005
    Date of Patent: November 28, 2006
    Assignee: E. I. du Pont de Nemours and Company
    Inventors: Keith W. Hutchenson, Kostantinos Kourtakis, Leo Ernest Manzer
  • Patent number: 7101654
    Abstract: The disclosed invention relates to novel norbornene-type monomers containing pendent lactone or sultone groups. The invention also relates to norbornene-type polymers and copolymers comprising one or more repeating units represented by the formula: and containing pendent lactone or sultone groups. These polymers and copolymers are useful in making photoimagable materials. The photoimagable materials are particularly suitable for use in photoresist compositions useful in 193 and 157 nm photolithography.
    Type: Grant
    Filed: January 14, 2004
    Date of Patent: September 5, 2006
    Assignee: Promerus LLC
    Inventors: Xiaoming Wu, Larry F. Rhodes, Lawrence Seger
  • Patent number: 7078404
    Abstract: The invention relates to acyl-3-carboxyphenylurea derivatives and to their physiologically tolerated salts and physiologically functional derivatives. The invention relates to compounds of formula I, in which the radicals have the given meanings, and to their physiologically tolerated salts and processes for preparing them. The compounds are, for example, suitable for use as antidiabetics.
    Type: Grant
    Filed: April 10, 2003
    Date of Patent: July 18, 2006
    Assignee: Sanofi-Aventis Deutschland GmbH
    Inventors: Elisabeth Defossa, Dieter Kadereit, Karl Schoenafinger, Thomas Klabunde, Hans-Joerg Burger, Andreas Herling, Karl-Ulrich Wendt, Erich Von Roedern, Alfons Enhsen
  • Patent number: 7053118
    Abstract: The subject invention provides novel compositions of biologically active compounds which can advantageously be used for inhibiting pathological cellular proliferation. The compounds of the subject invention have utility for use in the treatment of cancer, including tumors.
    Type: Grant
    Filed: March 6, 2003
    Date of Patent: May 30, 2006
    Assignee: Harbor Branch Oceanographic Institution, Inc.
    Inventors: Sarath P. Gunasekera, Ross E. Longley, Amy E. Wright, John K. Reed
  • Patent number: 7041838
    Abstract: A (meth)acrylate represented by the following formula (1): wherein each of R1, R2, R3 and R4 represents a hydrogen atom, a methyl group or an ethyl group; either one of X1 or X2 represents a (meth)acryloyloxy group and the other represents a hydrogen atom; both A1 and A2 represent hydrogen atoms, or A1 and A2 form —O—, —CH2— or —CH2CH2—, which can be produced by first producing a lactone by reducing an addition product obtained by the Diels-Alder reaction between 1,3-diene and maleic anhydride, and then hydrating the lactone to produce an alcohol followed by (meth)acrylation of the alcohol; a polymer produced by (co)polymerizing a monomer composition comprising the (meth)acrylate of the present invention is excellent in transparency, dry etching resistance, and solubility in organic solvents, and so it is preferably used as a resin for a chemically amplified resist composition.
    Type: Grant
    Filed: December 5, 2001
    Date of Patent: May 9, 2006
    Assignee: Mitsubishi Rayon Co., Ltd.
    Inventors: Yoshihiro Kamon, Tadayuki Fujiwara, Hideaki Kuwano, Hikaru Momose, Atsushi Koizumi
  • Patent number: 7037995
    Abstract: Novel tertiary (meth)acrylate compounds having a lactone structure are polymerizable into polymers having improved transparency, especially at the exposure wavelength of an excimer laser and dry etching resistance. Resist compositions comprising the polymers are sensitive to high-energy radiation, have a high resolution, and lend themselves to micropatterning with electron beams or deep-UV rays.
    Type: Grant
    Filed: September 29, 2003
    Date of Patent: May 2, 2006
    Assignee: Shin-Etsu Chemical Co., Ltd.
    Inventors: Takeru Watanabe, Takeshi Kinsho, Koji Hasegawa
  • Patent number: 6989455
    Abstract: In the process for the conversion of maleic acid to gamma-butyrolactone, 1.4-butanediol and/or tetrahydrofuran, a feedstream comprising maleic acid is hydrogenated in a first hydrogenation zone to produce a reaction product comprising succinic acid and unreacted hydrogen which is then supplied to a second hydrogenation zone, where succinic acid is converted to 1,4-butanediol, the temperatures of the feedstream comprising maleic acid and the first hydrogenation zone are controlled such that the temperature of maleic acid in the feedstream and the first hydrogenation zone does not exceed about 130° C., thereby minimizing the corrosive effects of the maleic acid and prolonging reactor life and improving overall process economics.
    Type: Grant
    Filed: August 21, 2003
    Date of Patent: January 24, 2006
    Assignee: ISP Investments Inc.
    Inventors: Robert P. Hepfer, Craig T. Miller, Gregory A. Norenberg, Thomas G. Attig, John R. Budge
  • Patent number: 6960573
    Abstract: Compounds expressed by the following general formula (1), [wherein, R01 and R02 are each independently a hydrogen atom or a protecting group for a hydroxyl group; Z is one out of the following formulae (1-1), (1-2), (1-3), (1-4) and (1-5)]. The compounds can be used as active ingredients of treating agents for inflammatory respiratory diseases, malignant tumors, rheumatoid arthritis, osteoporosis, diabetes mellitus, hypertension, alopecia, acne, psoriasis, dermatitis, hypercalcemia, hypoparathyroidism and metabolic disorder of cartilage.
    Type: Grant
    Filed: January 4, 2002
    Date of Patent: November 1, 2005
    Assignee: Teijin Limited
    Inventors: Kazuya Takenouchi, Qingzhi Gao, Kenji Manabe, Ryo Sogawa, Yasuhiro Takano, Seiichi Ishizuka
  • Patent number: 6958145
    Abstract: A method for the preparation of a compound of formula (II) wherein R1 and R2 are independently H, alkyl, alkoxy, oxoalkyl, alkenyl, aryl or arylalkyl whether unsubstituted or substituted, optionally interrupted by one or more hetero atoms, straight chain or branched chain, hydrophilic, hydrophobic or fluorophilic; R3, R4, R5 and R6 are independently or all hydrogen or halogen; provided that at least two of the R3, R4, R5 and R6 are halogens.
    Type: Grant
    Filed: June 28, 2001
    Date of Patent: October 25, 2005
    Assignee: Unisearch Limited
    Inventors: Naresh Kumar, Roger Wayne Read
  • Patent number: 6949536
    Abstract: This invention provides a compound of the formula: or its pharmaceutically acceptable salt thereof, wherein A is partially unsaturated or unsaturated five membered heterocyclic, or partially unsaturated or unsaturated five membered carbocyclic, wherein the 4-(sulfonyl)phenyl and the 4-substituted phenyl in the formula (I) are attached to ring atoms of Ring A, which are adjacent to each other; R1 is optionally substituted aryl or heteroaryl, with the proviso that when A is pyrazole, R1 is heteroaryl; R2 is C1-4 alkyl; halo-substituted C1-4 alkyl, C1-4 alkylamino, C1-4 dialkylamino or amino; R3, R4 and R5 are independently hydrogen, halo, C1-4 alkyl, halo-substituted C1-4 alkyl or the like; or two of R3, R4 and R5 are taken together with atoms to which they are attached and form a 4-7 membered ring. R6 and R7 are independently hydrogen, halo, C1-4 alkyl, halo-substituted C1-4 alkyl, C1-4 alkoxy, C1-4 alkylthio, C1-4 alkylamino or N,N-di C1-4 alkylamino; and m and n are independently 1, 2, 3 or 4.
    Type: Grant
    Filed: February 3, 2004
    Date of Patent: September 27, 2005
    Assignee: Pfizer, Inc.
    Inventors: Kazuo Ando, Tomoki Kato, Akiyoshi Kawai, Tomomi Nonomura
  • Patent number: 6906051
    Abstract: The present invention relates to a class of compounds represented by the Formula I: or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula I, and methods of selectively inhibiting or antagonizing the ?V?3 and/or the ?V?5 integrin.
    Type: Grant
    Filed: November 19, 2003
    Date of Patent: June 14, 2005
    Assignee: Pharmacia Corporation
    Inventors: Peter Ruminiski, Thomas D. Penning, Lan Jiang, Balekudru Devadas, Thomas Rogers, Jennifer VanCamp, Chester Yuan
  • Patent number: 6900242
    Abstract: Compounds of Formula Ia and Ic having a lactone structure and an methylene group at the alpha-position of the lactone structure and methods for using and making the compounds have been disclosed. The lactone compounds can be reacted with an neucleaphilic agent to open the lactone ring to a compound of Formula Ib. The lactone of Formula Ia and its functional derivatives have been isolated from Securidaca virgata. These compounds are referred to as LMSV-6 or Securolide™. The purified compounds have demonstrated activity in assays for anti-bacterial and anti-fungal activities, and for treating proliferation disorders such as cancer. Based on the in vitro assays, the lactones are useful for treating proliferation disorders including, for example, breast cancer, colon cancer, rectal cancer, stomach cancer, pancreatic cancer, lung cancer, liver cancer, ovarian cancer, esophageal cancer, and leukemia.
    Type: Grant
    Filed: June 12, 2002
    Date of Patent: May 31, 2005
    Assignee: Magnachem International Laboratories, Inc.
    Inventor: David Terrero
  • Patent number: RE39794
    Abstract: A process is described for the co-production of maleic anhydride and at least one C4 compound selected from butane-1,4-diol, ?-butyrolactone, and tetrahydrofuran in which maleic anhydride is produced by partial oxidation of a hydrocarbon feedstock selected from C4 hydrocarbons and benzene to yield a vaporous reaction effluent stream comprising maleic anhydride, water, unconverted hydrocarbon feedstock, and carbon oxides. A part of the maleic anhydride present in the vaporous reaction effluent stream is condensed to form a crude maleic anhydride stream and leave a residual vaporous stream containing residual amounts of maleic anhydride. Further maleic anhydride is absorbed from the residual vaporous stream by absorption in an organic solvent, water or an aqueous solution. Maleic anhydride is then recovered from the loaded liquid absorptions medium.
    Type: Grant
    Filed: October 4, 2000
    Date of Patent: August 21, 2007
    Assignee: Davy Process Technology Limited
    Inventors: David Mark Sutton, Andrew George Hiles, Adrian Francis Backes