The Lactone Ring Is Five-membered Patents (Class 549/295)
  • Patent number: 6891036
    Abstract: The present invention relates to a new process in 3 steps starting from 2-C-methyl-D-ribopentono-1,4-lactone for the preparation of tetra-acyl ribofuranose derivatives of formula (I): useful in the synthesis of nucleotides.
    Type: Grant
    Filed: May 27, 2003
    Date of Patent: May 10, 2005
    Assignee: Inalco S.p.A.
    Inventors: Giancarlo Tamerlani, Liana Salsini, Ilaria Lombardi, Debora Bartalucci, Giovanni Cipolletti
  • Patent number: 6846389
    Abstract: In a process for the continuous fractional distillation of mixtures comprising tetrahydrofuran, ?-butyrolactone and/or 1,4-butanediol to give at least three fractions, the fractionation is carried out in an assembly of distillation columns comprising at least one dividing wall column or at least one assembly of thermally coupled conventional distillation columns.
    Type: Grant
    Filed: May 3, 2001
    Date of Patent: January 25, 2005
    Assignee: BASF Aktiengesellschaft
    Inventors: Gerd Kaibel, Alexander Weck, Ralf-Thomas Rahn
  • Publication number: 20040224990
    Abstract: The invention relates to a process for preparing the compounds of general formula I 1
    Type: Application
    Filed: March 10, 2004
    Publication date: November 11, 2004
    Applicant: Boehringer Ingelheim International GmbH
    Inventors: Franz Dietrich Klingler, Michael Steigerwald, Richard Ehlenz
  • Patent number: 6797830
    Abstract: The present invention provides a process for producing an oxide from an alcohol compound, the process comprising the steps of causing silica gel to carry the alcohol compound thereon and an oxidative catalyst thereon, and oxidizing the alcohol compound in the presence of an oxidizing agent, giving an oxide higher in oxidizing degree than the alcohol compound, and also provides a process for producing an oxide from an alcohol compound, the process comprising the steps of causing silica gel to carry the alcohol compound, and subjecting the alcohol compound to an electrolytic oxidation, giving an oxide higher in oxidizing degree than the alcohol compound.
    Type: Grant
    Filed: November 28, 2001
    Date of Patent: September 28, 2004
    Assignee: Otsuka Kagaku Kabushiki Kaisha
    Inventors: Hideo Tanaka, Yutaka Kameyama
  • Patent number: 6787655
    Abstract: One aspect of the present invention relates to methods for the transition-metal-catalyzed asymmetric 1,4-addition of a nucleophile, e.g., hydride, to cyclic and acyclic enoates and enones. In certain embodiments of the methods of the present invention, the transition metal catalyst consists essentially of copper and an asymmetric bidentate bisphosphine ligand.
    Type: Grant
    Filed: October 15, 2002
    Date of Patent: September 7, 2004
    Assignee: Massachusetts Institute of Technology
    Inventors: Stephen L. Buchwald, Daniel H. Appella, Yasunori Moritani, Ryo Shintani, Valdas Jurkauskas
  • Patent number: 6784302
    Abstract: An optically active lactone compound is produced by using a Zr(salen) complex of the following formula (I) or its enantiomer as a catalyst and subjecting a cyclic ketone compound to a Baeyer-Villiger reaction with at least one oxidizer selected from hydrogen peroxide, aqueous hydrogen peroxide and urea-hydrogen peroxide adduct in a solvent: wherein Ar1 is an aryl group having a carbon number of 10 to 16 and Y is a phenoxy group or an alkoxy group having a carbon number of 1 to 10.
    Type: Grant
    Filed: April 3, 2003
    Date of Patent: August 31, 2004
    Assignee: Kyushu University
    Inventors: Tsutomu Katsuki, Akira Watanabe, Tatsuya Uchida
  • Patent number: 6768013
    Abstract: A novel process for the direct oxidation of hydrogen and hydrocarbons is disclosed, where the explosion risks inherent in gas phase oxidations are substantially eliminated. Gaseous oxidation reactants are soluble in a first reaction solvent phase such as a perfluorocarbon (e.g. C8F18) and the oxidation product is preferentially soluble in a second product solvent phase such as water or a dilute acid. A solid catalyst such as palladium on alumina is then contacted with the dissolved reactants. The oxidation product such as hydrogen peroxide may be separated from the reaction solvent phase by extraction into the immiscible product solvent phase and then separated from it by distillation, thereby allowing re-use of the aqueous phase. The present invention may be carried out using a two-phase reaction system whereby both the reaction solvent and product solvent are contained within a reaction vessel into which the solid catalyst is slurried and mechanically agitated to promote the reaction.
    Type: Grant
    Filed: June 15, 2001
    Date of Patent: July 27, 2004
    Assignee: UOP LLC
    Inventor: Peter R. Pujado
  • Patent number: 6727238
    Abstract: This invention provides a compound of the formula: or its pharmaceutically acceptable salt thereof, wherein A is partially unsaturated or unsaturated five membered heterocyclic, or partially unsaturated or unsaturated five membered carbocyclic, wherein the 4-(sulfonyl)phenyl and the 4-substituted phenyl in the formula (I) are attached to ring atoms of Ring A, which are adjacent to each other; R1 is optionally substituted aryl or heteroaryl, with the proviso that when A is pyrazole, R1 is heteroaryl; R2 is C1-4 alkyl, halo-substituted C1-4 alkyl, C1-4 alkylamino, C1-4 dialkylamino or amino; R3, R4 and R5 are independently hydrogen, halo,, C1-4 alkyl, halo-substituted C1-4 alkyl or the like; or two of R3, R4 and R5 are taken together with atoms to which they are attached and form a 4-7 membered ring; R6 and R7 are independently hydrogen, halo, C1-4 alkyl, halo-substituted C1-4 alkyl, C1-4 alkoxy, C1-4 alkylthio, C1-4 alkylamino or N,N-di C1-4 alkylamino; and m and n are independently 1, 2, 3 o
    Type: Grant
    Filed: June 18, 2003
    Date of Patent: April 27, 2004
    Assignee: Pfizer Inc.
    Inventors: Kazuo Ando, Tomoki Kato, Akiyoshi Kawai, Tomomi Nonomura
  • Publication number: 20040077885
    Abstract: A process for production of tetrahydrofuran, gamma butyrolactone, 1,4 butanediol and the like from a hydrogenatable precursor such as maleic acid, succinic acid, corresponding esters and their mixtures and the like in an aqueous solution in the presence of hydrogen using a noble metal catalyst, wherein a deactivated noble metal catalyst is regenerated by contacting the catalyst with a solvent, separating the solvent from the catalyst, and then reusing the regenerated catalyst in the process.
    Type: Application
    Filed: October 21, 2002
    Publication date: April 22, 2004
    Inventors: Daniel Campos, Richard Edward Ernst
  • Patent number: 6720327
    Abstract: The present invention relates to a class of compounds represented by the Formula I. or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula I, and methods of selectively inhibiting or antagonizing the &agr;v&bgr;3 and/or the &agr;v&bgr;5 integrin.
    Type: Grant
    Filed: September 26, 2001
    Date of Patent: April 13, 2004
    Assignee: Pharmacia Corporation
    Inventors: Peter Ruminski, Thomas D. Penning, Lan Jiang, Balekudru Devadas, Thomas Rogers, Jennifer VanCamp, Chester Yuan
  • Publication number: 20040067563
    Abstract: Fermentation based methods for producing mycolactones allows one to produce large quantities of mycolactones, which can be purified by extraction and chromatography to yield pure preparations of mycolactones A, B, C, and D.
    Type: Application
    Filed: May 7, 2003
    Publication date: April 8, 2004
    Inventors: Robert Arslanian, John Carney
  • Patent number: 6716832
    Abstract: The present invention relates to novel arylphenyl-substituted cyclic ketoenols of the formula (I): in which X represents halogen, alkyl, alkoxy, alkenyloxy, alkylthio, alkylsulphinyl, alkylsulphonyl, halogenalkyl, halogeno-alkoxy, halogenoalkenyloxy, nitro, cyano or in each case optionally substituted phenyl, phenoxy, phenylthio, phenyl-alkoxy or phenylalkylthio, Y represents in each case optionally substituted cycloalkyl, aryl or hetaryl, Z represents hydrogen, halogen, alkyl, alkoxy, alkenyloxy, halogenoalkyl, halogenoalkoxy, halogenoalkenyloxy, nitro or cyano, CKE represents one of the groups: in which A, B, D, G and Q1 to Q6 are each as defined in the description, to a plurality of processes for their preparation and to their use as pesticides and herbicides.
    Type: Grant
    Filed: May 2, 2002
    Date of Patent: April 6, 2004
    Assignee: Bayer Aktiengesellschaft
    Inventors: Folker Lieb, Reiner Fischer, Alan Graff, Udo Schneider, Thomas Bretschneider, Christoph Erdelen, Wolfram Andersch, Mark-Wilhelm Drewes, Markus Dollinger, Ingo Wetcholowsky, Randy Allen Myers
  • Patent number: 6713036
    Abstract: A novel process for continuously mixing and reacting at least two fluids are disclosed. Excellent mixing and superior pressure drop characteristics are achieved using cyclone mixing where at least two supply channels feed a mixing chamber to create a vortex of the fluids to be mixed. The alignment of the supply channels is such that fluids are introduced into the chamber at both tangential and radial directions. In the case of gas/liquid mixing, particularly advantageous is the injection of the liquid stream tangentially and the gas stream radially. Reaction of the fluids can take place within the mixing chamber or in a separate reactor in fluid communication with the mixing chamber outlet. The process is especially useful for reacting potentially explosive mixtures of reactants where a homogeneous reactor feed mixture is critical to maintaining a non-explosive environment.
    Type: Grant
    Filed: May 7, 2001
    Date of Patent: March 30, 2004
    Assignee: UOP LLC
    Inventors: Kurt M. Vanden Bussche, Suheil F. Abdo, Anil R. Oroskar
  • Patent number: 6703515
    Abstract: The present invention relates to a novel chiral compound of Hibiscus acid bearing lactone moiety of formula I, Wherein: R1═R2═alkali salt of carboxylic acid or acid chloride or lower esters or the N-substituted cyclic imides. R3═hydroxyl or protected hydroxyl group and a process for preparing the same.
    Type: Grant
    Filed: September 5, 2001
    Date of Patent: March 9, 2004
    Assignee: Department of Science and Technology, Technology Bhavan
    Inventors: Ibrahim Ibnu Saud, Chitra Gopinath, Beena Thomas
  • Patent number: 6699910
    Abstract: The present invention relates to novel ketone compounds, compositions comprising ketone compounds, and methods useful for treating and preventing cardiovascular diseases, dyslipidemias, dysproteinemias, and glucose metabolism disorders comprising administering a composition comprising a ketone compound. The compounds, compositions, and methods of the invention are also useful for treating and preventing Alzheimer's Disease, Syndrome X, peroxisome proliferator activated receptor-related disorders, septicemia, thrombotic disorders, obesity, pancreatitis, hypertension, renal disease, cancer, inflammation, and impotence. In certain embodiments, the compounds, compositions, and methods of the invention are useful in combination therapy with other therapeutics, such as hypocholesterolemic and hypoglycemic agents.
    Type: Grant
    Filed: October 11, 2001
    Date of Patent: March 2, 2004
    Assignee: Esperion Therapeutics, Inc.
    Inventors: Jean-Louis Henri Dasseux, Carmen Daniela Oniciu
  • Publication number: 20040039213
    Abstract: In the process for the conversion of maleic acid to gamma-butyrolactone, 1.4-butanediol and/or tetrahydrofuran, a feedstream comprising maleic acid is hydrogenated in a first hydrogenation zone to produce a reaction product comprising succinic acid and unreacted hydrogen which is then supplied to a second hydrogenation zone, where succinic acid is converted to 1,4-butanediol, the temperatures of the feedstream comprising maleic acid and the first hydrogenation zone are controlled such that the temperature of maleic acid in the feedstream and the first hydrogenation zone does not exceed about 130° C., thereby minimizing the corrosive effects of the maleic acid and prolonging reactor life and improving overall process economics.
    Type: Application
    Filed: August 21, 2003
    Publication date: February 26, 2004
    Inventors: Robert P. Hepfer, Craig T. Miller, Gregory A. Norenberg, Thomas G. Attig, John R. Budge
  • Patent number: 6696217
    Abstract: A photosensitive monomer including a methylene butyrolactone derivative represented by the following formula: wherein R1 is a hydrogen atom or alkyl group, R2 is an acid-labile group, X is a hydrogen atom, or substituted or unsubstituted alkyl group having 1 to 10 carbon atoms, and Y is a substituted or unsubstitued alkyl group or alicyclic hydrocarbon group having 1 to 20 carbon atoms.
    Type: Grant
    Filed: February 20, 2002
    Date of Patent: February 24, 2004
    Assignee: Samsung Electronics Co., Ltd.
    Inventors: Kwang-sub Yoon, Sang-gyun Woo
  • Patent number: 6693092
    Abstract: The present invention relates to novel arylphenyl-substituted cyclic ketoenols of the formula (I) in which X represents halogen, alkyl, alkoxy, alkenyloxy, alkylthio, alkylsulphinyl, alkylsulphonyl, halogenoalkyl, halogenoalkoxy, halogenoalkenyloxy, nitro, cyano or in each case optionally substituted phenyl, phenoxy, phenylthio, phenylalkoxy or phenylalkylthio, Y represents in each case optionally substituted cycloalkyl, aryl or hetaryl, W and Y independently of one another each represent hydrogen, halogen, alkyl, alkoxy, alkenyloxy, halogenoalkyl, halogenoalkoxy, halogenoalkenyloxy, nitro or cyano, CKE represents one of the groups  in which A, B, D, G and Q1 to Q6 are each as defined in the description, to a plurality of processes for their preparation and to their use as pesticides and herbicides.
    Type: Grant
    Filed: May 9, 2002
    Date of Patent: February 17, 2004
    Assignee: Bayer Aktiengesellschaft
    Inventors: Folker Lieb, Reiner Fischer, Alan Graff, Udo Schneider, Thomas Bretshneider, Christoph Erdelen, Wolfram Andersch, Mark Wilhelm Drewes, Markus Dollinger, Ingo Wetcholowsky, Randy Allen Myers
  • Patent number: 6686390
    Abstract: The present invention relates to novel heterocyclic compounds of the general formula (I), their derivatives, their analogs, their tautomeric forms, their stereoisomers, their regioisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them.
    Type: Grant
    Filed: May 21, 2001
    Date of Patent: February 3, 2004
    Assignee: Dr. Reddy's Laboratories Limited
    Inventors: Manojit Pal, Koteswar Rao Yeleswarapu, Rajagopalan Ramanujam, Parimal Misra, Prem Kumar Mamnoor, Seshagiri Rao Casturi
  • Patent number: 6673515
    Abstract: The invention provides a polymer comprising recurring units of formula (1—1) or (1-2) wherein k is 0 or 1, m is 0, 1, 2, 3 or 4, and n is 1 or 2 and having a weight average molecular weight of 1,000 to 500,000. A resist composition comprising the polymer as a base resin is sensitive to high-energy radiation, has excellent sensitivity, resolution, and etching resistance, and lends itself to micropatterning with electron beams or deep-UV.
    Type: Grant
    Filed: September 14, 2001
    Date of Patent: January 6, 2004
    Assignee: Shin-Etsu Chemical Co., Ltd.
    Inventors: Tsunehiro Nishi, Mutsuo Nakashima, Seiichiro Tachibana, Takeshi Kinsho, Koji Hasegawa, Takeru Watanabe, Jun Hatakeyama
  • Publication number: 20030225282
    Abstract: This invention provides a process for the arylation of lactones to form to chiral and achiral aryllactones having high enantioselectivity where applicable.
    Type: Application
    Filed: March 18, 2003
    Publication date: December 4, 2003
    Inventors: Tony Yantao Zhang, Hongbin Zhang, Christophor Scott Proctor
  • Patent number: 6649776
    Abstract: Alpha-methylenelactones are produced from butyrolactone and valerolactone by the addition of formaldehyde in a supercritical fluid in the presence of a catalyst and a phase transfer agent.
    Type: Grant
    Filed: January 7, 2003
    Date of Patent: November 18, 2003
    Assignee: E. I. du Pont de Nemours and Company
    Inventors: Leo E. Manzer, Keith W. Hutchenson
  • Publication number: 20030212281
    Abstract: A natural inexpensive acyclic monoterpene ketone (dihydrotagetone) of formula (4), isolated from the oil of Tagetes sp., was smoothly oxidized with meta-periodate/potassium permanganate into 2,6-dimethyl-4-oxo-heptanoic acid of formula (3), the reduction of 3 with metal hydride such as sodium borohydride or lithium aluminium hydride provided 4-hydroxyacid of formula (2) which on without isolation undergone lactonisation in acidic medium furnished two chiral centered 5-isobutyl-3-methyl-4,5-dihydro-2(3H)-furanone of formula (1) as an analogue of whisky lactone 5-butyl-4-methyl-4,5-dihydro-2(3H)-furanone of formula (1a) responsible for high quality of alcoholic beverage (whisky, wine, brandy and scotch), in addition, coconut flavoured 5-butyl-4-methyl-4,5-dihydro-2(3H)-furanone of formula (1) is also as an analogue of coconut aldehyde (&ggr;-nonalactone, F.E.M.A. No. 2751) of formula (1b) which is responsible for flavouring a wide range of food stuffs including baked goods and confectionery.
    Type: Application
    Filed: June 2, 2003
    Publication date: November 13, 2003
    Applicant: Council of Scientific & Industiral Research
    Inventors: Arun Kumar Sinha, Bhupendra Prasad Joshi, Ruchi Dogra
  • Publication number: 20030199698
    Abstract: Novel compounds of the formula I 1
    Type: Application
    Filed: May 16, 2003
    Publication date: October 23, 2003
    Inventors: Horst Juraszyk, Dieter Dorsch, Werner Mederski, Christos Tsaklakidis, Christopher Barnes, Johannes Gleitz
  • Publication number: 20030187249
    Abstract: The present invention relates to a method and catalysts for the stereoselective addition of a nucleophile to a reactive &pgr;-bond of a substrate. The chiral, non-racemic catalysts of the present invention constitute the first examples of catalysts for nucleophilic additions that comprise a main-group metal and a tri- or tetra-dentate ligand.
    Type: Application
    Filed: December 20, 2002
    Publication date: October 2, 2003
    Inventors: Eric N. Jacobsen, Matthew S. Sigman
  • Patent number: 6620949
    Abstract: A process is described for the co-production of maleic anhydride and at least one C4 compound selected from butane-1,4-diol, &ggr;-butyrolactone, and tetrahydrofuran in which maleic anhydride is produced by partial oxidation of a hydrocarbon feedstock selected from C4 hydrocarbons and benzene to yield a vaporous reaction effluent stream comprising maleic anhydride, water, unconverted hydrocarbon feedstock, and carbon oxides. A part of the maleic anhydride present in the vaporous reaction effluent stream is condensed to form a crude maleic anhydride stream and leave a residual vaporous stream containing residual amounts of maleic anhydride. Further maleic anhydride is absorbed from the residual vaporous stream by absorption in an organic solvent, water or an aqueous solution. Maleic anhydride is then recovered from the loaded liquid absorptions medium.
    Type: Grant
    Filed: July 22, 2002
    Date of Patent: September 16, 2003
    Assignee: Davy Process Technology Limited
    Inventors: David Mark Sutton, Andrew George Hiles, Adrian Francis Backes
  • Publication number: 20030158424
    Abstract: The present invention relates to novel substituted &agr;,&bgr;-fused butyrolactones, to processes for their preparation and to their use for the prevention and/or treatment of disorders caused by hyper- or hypofunction of the glutamatergic system, in particular of cerebral ischaemias, craniocerebral trauma, states of pain or CNS-mediated spasms.
    Type: Application
    Filed: July 25, 2002
    Publication date: August 21, 2003
    Inventors: Andreas Stolle, Horst-Peter Antonicek, Stephen Lensky, Arnd Voerste, Thomas Muller, Jorg Baumgarten, Karsten von dem Bruch, Gerhard Muller, Udo Stropp, Ervin Horvath, Jean-Marie-Viktor de Vry, Rudy Schreiber
  • Patent number: 6579992
    Abstract: A natural inexpensive acyclic monoterpene ketone (dihydrotagetone) of formula (4), isolated from the oil of Tagetes sp., was smoothly oxidized with meta-periodate/potassium permanganate into 2,6-dimethyl-4-oxo-heptanoic acid of formula (3), the reduction of 3 with metal hydride such as sodium borohydride or lithium aluminium hydride provided 4-hydroxyacid of formula (2) which on without isolation undergone lactonization in acidic medium furnished two chiral centered 5-isobutyl-3-methyl-4,5-dihydro-2(3H)-furanone of formula (1) as an analogue of whisky lactone 5-butyl-4-methyl-4,5-dihydro-2(3H)-furanone of formula (1a) responsible for high quality of alcoholic beverage (whisky, wine, brandy and scotch), in addition, coconut flavored 5-butyl-4-methyl-4,5-dihydro-2(3H)-furanone of formula (1) is also as an analogue of coconut aldehyde (&ggr;-nonalactone, F.E.M.A. No. 2751) of formula (1b) which is responsible for flavoring a wide range of food stuffs including baked goods and confectionery.
    Type: Grant
    Filed: March 23, 2001
    Date of Patent: June 17, 2003
    Assignee: Council of Scientific & Industrial Research
    Inventors: Arun Kumar Sinha, Bhupendra Prasad Joshi, Ruchi Dogra
  • Publication number: 20030106786
    Abstract: In a process for the continuous fractional distillation of mixtures comprising tetrahydrofuran, &ggr;-butyrolactone and/or 1,4-butanediol to give at least three fractions, the fractionation is carried out in an assembly of distillation columns comprising at least one dividing wall column or at least one assembly of thermally coupled conventional distillation columns.
    Type: Application
    Filed: October 29, 2002
    Publication date: June 12, 2003
    Inventors: Gerd Kaibel, Alexander Weck, Ralf-Thomas Rahn
  • Publication number: 20030109722
    Abstract: A method of refining a crystal of a crude cyclic ester comprises the steps of supplying the crude cyclic ester to a vertically extending cylindrical refiner (1) from an inlet (3) provided at a lower part of the refiner (1), agitating the crude cyclic ester by an agitator provided in the refiner (1) to make the crude cyclic ester flow upwardly, refining the crystals of the crude cyclic ester by counterflow-contact between the upflowing crude cyclic ester and a downflowing melted liquid containing a refined crystal component, and taking out refined crystals of the crude cyclic ester from an outlet (4) provided at an upper part of the refiner (1).
    Type: Application
    Filed: September 30, 2002
    Publication date: June 12, 2003
    Inventors: Tetsuo Ejiri, Kazuyuki Yamane, Kentaro Otawara
  • Patent number: 6559322
    Abstract: The present invention provides a new biocatalyst whole cell system for converting cyclic ketones such as cyclopentanone/cyclohexanone to the corresponding lactones such as valerolactone/caprolactone. Another novel aspect of the present invention is that biocatalyst fungus Fusarium oxysporum f.sp. ciceri NCIM 1282 species has been found to be an efficient biocatalyst system for any biotransformation for the first time.
    Type: Grant
    Filed: December 21, 2001
    Date of Patent: May 6, 2003
    Assignee: Council of Scientific and Industrial Research
    Inventors: Deendayal Mandal, Absar Ahmad, Mohammed Islam Khan, Rajiv Kumar
  • Patent number: 6552217
    Abstract: Disclosed is a 4-step process for the preparation of alkyl esters of 1-methylcyclopropanecarboxylic acid which comprises the steps of (1) converting &ggr;-butyrolactone to &agr;-methyl-&ggr;-butyrolactone; (2) converting the &agr;-methyl-&ggr;-butyrolactone from step (1) to an alkyl 4-halo-2-methylbutyrate; (3) producing a xylene solution of the alkyl 4-halo-2-methylbutyrate; and (4) contacting the xylene solution of an alkyl 4-halo-2-methylbutyrate from step (3) with an alkali metal alkoxide under conditions of temperature and pressure which causes vaporization of (i) an alkanol as it is formed and (ii) an alkyl 1-methylcyclopropanecarboxylate as it is formed from the alkyl 4-halo-2-methylbutyrate. Also disclosed are processes whereby the alkyl 1-methylcyclopropanecarboxylate, prepared as described above, is converted to 1-methylcyclopropylamine.
    Type: Grant
    Filed: July 2, 2001
    Date of Patent: April 22, 2003
    Assignee: Eastman Chemical Company
    Inventors: John Clark Hubbs, David Carl Attride, Neil Warren Boaz, James Charles Ciula, John Thorton Maddox, Thomas Nabih, William Dell Nottingham, David Chris Spencer
  • Patent number: 6541646
    Abstract: The invention relates to a method for producing compounds of general formula (I) wherein R1 is selected from the following groups: (a) OR5 and (b) mono-, di-, or tri-substituted phenyl; and R2 represents a group (C1-C6) alkyl. The method is characterized in that it comprises the following steps: a) reacting a compound of general formula (III) with an acid of general formula R1CH2 COOH (III) in a water-free medium; b) reacting the resulting compound with a strong base in an aprotic solvent in order to obtain an intermediate cyclic compound which forms a compound of general formula (I) after dehydration; and c) isolating said resulting compound of general formula (I).
    Type: Grant
    Filed: April 8, 2002
    Date of Patent: April 1, 2003
    Assignee: Merial
    Inventors: Laetitia Canali, Paul Cruciani, Gilles Oddon
  • Patent number: 6531460
    Abstract: Compounds expressed by the following general formula (1), The compounds can be used as active ingredients of treating agents for inflammatory respiratory diseases, malignant tumors, rheumatoid arthritis, osteoporosis, diabetes mellitus, hypertension; alopecia, acne, psoriasis, dermatitis, hypercalcemia, hypoparathyroidism and metabolic disorder of cartilage.
    Type: Grant
    Filed: April 23, 2001
    Date of Patent: March 11, 2003
    Assignee: Teijin Limited
    Inventors: Kazuya Takenouchi, Qingzhi Gao, Kenji Manabe, Ryo Sogawa, Yasuhiro Takano, Seiichi Ishizuka
  • Patent number: 6531616
    Abstract: This invention pertains to a process for making &agr;-methylenelactones and &agr;-substitute hydrocarbylidene lactones. More specifically, the present invention obtains high yields of &agr;-methylene-&ggr;-butyrolactone by heating &ggr;-butyrolactone and diethyl oxalate in the presence of a base. The second step comprises treatment of the &agr;-oxalyl enolate salt with formaldehyde to afford the &agr;-methylene-&ggr;-butyrolactone.
    Type: Grant
    Filed: December 21, 2001
    Date of Patent: March 11, 2003
    Assignee: E. I. du Pont de Nemours and Company
    Inventors: Rutger D. Puts, Charles Brandenburg, Kenneth R. Tarburton
  • Patent number: 6521763
    Abstract: In a process for preparing GBL by reaction of 1,4 butanediol over a copper catalyst, use is made of a 1,4 butanediol-containing reaction mixture which comprises further alcohols other than 1,4-butanediol and water.
    Type: Grant
    Filed: February 28, 2002
    Date of Patent: February 18, 2003
    Assignee: BASF Aktiengesellschaft
    Inventors: Rolf Fischer, Rolf Pinkos
  • Publication number: 20030027063
    Abstract: A three dimensional optical data storage and retrieval system that includes a three dimensional optical data storage medium and an apparatus for providing access to data stored on the medium. The data storage medium includes an optical data storage material which either a low molecular weight or polymeric glassy solid that are capable of undergoing multi-photon excitation that are energetically different in the write and read cycles. The optical data storage materials provide substantially higher storage capacities relative to conventional materials, and show high robustness in that written and stored data can undergo multiple read cycles without erasure or overwriting. An apparatus for data recording and accessing stored data on the medium includes a controllable variable energy photo-emitting excitation source and an emission photo-detector.
    Type: Application
    Filed: July 12, 2002
    Publication date: February 6, 2003
    Applicant: The Trustees of Boston College
    Inventors: John T. Fourkas, Christopher E. Olson, Michael J.R. Previte
  • Patent number: 6512127
    Abstract: The present invention is directed towards a process for the preparation of enantiomerically enriched 4-hydroxymethyl-&ggr;-butyrolactone (I). By kinetic racemate cleavage of racemic epoxide of the general formula (II) wherein R represents a (C1-C8)-alkyl radical, a (C8-C16)-aryl radical, with a nucleophile and a Jacobsen catalyst there is obtained enantiomerically enriched (I). Use of the lactone so prepared.
    Type: Grant
    Filed: August 24, 2001
    Date of Patent: January 28, 2003
    Assignee: Degussa AG
    Inventors: Kai Rossen, Stefan Eils
  • Patent number: 6492532
    Abstract: The present invention provides a method for producing a carbonyl compound by dehydrogenating an alcohol. Namely, it relates to a method for producing a carbonyl compound, which comprises dehydrogenating an alcohol in the presence of a complex compound catalyst comprising ruthenium and an organic phosphine wherein aliphatic carbons are bonded to two or more of the three bonding hands of the phosphorus atom.
    Type: Grant
    Filed: August 21, 2001
    Date of Patent: December 10, 2002
    Assignee: Mitsubishi Chemical Corporation
    Inventors: Masaru Utsunomiya, Kazunari Takahashi, Yoko Seto, Souichi Orita, Souichi Amano
  • Publication number: 20020183366
    Abstract: This invention describes novel compounds that are cyclooxygenase 2 (COX-2) selective inhibitors and novel compositions comprising at least one cyclooxygenase 2 (COX-2) selective inhibitor, and, optionally, at least one compound that donates, transfers or releases nitric oxide, stimulates endogenous synthesis of nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor or is a substrate for nitric oxide synthase, and/or, optionally, at least one therapeutic agent. The invention also provides novel kits comprising at least one COX-2 selective inhibitor, and, optionally, at least one nitric oxide donor, and/or, optionally, at least one therapeutic agent. The novel cyclooxygenase 2 selective inhibitors of the invention can be optionally nitrosated and/or nitrosylated.
    Type: Application
    Filed: March 22, 2002
    Publication date: December 5, 2002
    Inventors: David S. Garvey, Joseph D. Schroeder
  • Patent number: 6472543
    Abstract: Lactone compounds of formula (1) are novel and useful as monomers to form base resins for use in chemically amplified resist compositions adapted for micropatterning lithography. Letter k is 0 or 1 and m is an integer of 1-8.
    Type: Grant
    Filed: July 5, 2001
    Date of Patent: October 29, 2002
    Assignee: Shin-Etsu Chemical Co., Ltd.
    Inventors: Takeshi Kinsho, Takeru Watanabe, Koji Hasegawa, Tsunehiro Nishi, Mutsuo Nakashima, Seiichiro Tachibana, Jun Hatakeyama
  • Patent number: 6465664
    Abstract: One aspect of the present invention relates to methods for the transition-metal-catalyzed asymmetric 1,4-addition of a nucleophile, e.g., hydride, to cyclic and acyclic enoates and enones. In certain embodiments of the methods of the present invention, the transition metal catalyst consists essentially of copper and an asymmetric bidentate bisphosphine ligand.
    Type: Grant
    Filed: September 13, 2000
    Date of Patent: October 15, 2002
    Assignee: Massachusetts Institute of Technology
    Inventors: Stephen L Buchwald, Daniel H. Appella, Yasunori Moritani, Ryo Shintani, Valdas Jurkauskas
  • Publication number: 20020137949
    Abstract: A natural inexpensive acyclic monoterpene ketone (dihydrotagetone) of formula (4), isolated from the oil of Tagetes sp., was smoothly oxidized with metaperiodate/potassium permanganate into 2,6-dimethyl-4-oxo-heptanoic acid of formula (3), the reduction of 3 with metal hydride such as sodium borohydride or lithium aluminium hydride provided 4-hydroxyacid of formula (2) which on without isolation undergone lactonisation in acidic medium furnished two chiral centered 5-isobutyl-3-methyl-4,5-dihydro-2(3H)-furanone of formula (1) as an analogue of whisky lactone 5-butyl-4-methyl-4,5-dihydro-2(3H)-furanone of formula (1a) responsible for high quality of alcoholic beverage (whisky, wine, brandy and scotch), in addition, coconut flavoured 5-butyl-4-methyl-4,5-dihydro-2(3H)-furanone of formula (1) is also as an analogue of coconut aldehyde (&ggr;-nonalactone, F.E.M.A. No. 2751) of formula (1b) which is responsible for flavouring a wide range of food stuffs including baked goods and confectionery.
    Type: Application
    Filed: March 23, 2001
    Publication date: September 26, 2002
    Inventors: Arun Kumar Sinha, Bhupendra Prasad Joshi, Ruchi Dogra
  • Patent number: 6433197
    Abstract: The invention provides new methods for preparation of cyclic oxygen compounds, including 2,5-disubstituted tetrahydrofurans, 2,6-disubstituted tetrahydropyrans, 2,7-disubstituted oxepanes and 2,8-oxocanes. The invention also provides new cyclic oxygen compounds and pharmaceutical compositions and therapeutic methods that comprise such compounds.
    Type: Grant
    Filed: October 2, 2001
    Date of Patent: August 13, 2002
    Assignee: Millennium Pharmaceuticals, Inc.
    Inventors: Mukund Shankar Chorghade, Mukund Keshao Gurjar, Palakodety Radha Krishna, Sista Venkata Sai Lalitha, Kashinath Sadalapure, Susanta Sekhar Adhikari, Andappan Murugaiah Subbaiah Murugaiah, Batchu Venkateswara Rao, Levadala Murali Krishna, Sunil Vyankatesh Mhaskar, Gangavaram Vasantha Madhava Sharma, Tangallapally Rajendra Prasad, Punna Sreenivas, Vavilala Goverdhan Reddy, Aminul Islam, Alla Venkata Rama Rao, Hymavathi Lanka, Bethi Sridhar Reddy, Chittineni Hari Prasad
  • Patent number: 6433192
    Abstract: In a process for preparing 1,4-butanediol, tetrahydrofuran and &ggr;-butyrolactone by oxidation of butane to give a product stream comprising maleic anhydride, absorption of maleic anhydride from the product stream using a high-boiling alcohol to give a liquid absorption product comprising monoesters and diesters of maleic acid and also high-boiling alcohol, after-esterification of the liquid absorption product and subsequent hydrogenation of the after-esterified product in the liquid phase, the high-boiling alcohol is a polyhydric alcohol having a boiling point at atmospheric pressure of above 233° C. and the after-esterified product has an acid number of less than 30 mg KOH/g and a water content of less than 1% by weight.
    Type: Grant
    Filed: June 4, 2001
    Date of Patent: August 13, 2002
    Assignee: BASF Aktiengesellschaft
    Inventors: Rolf Fischer, Gerd Kaibel, Rolf Pinkos, Ralf-Thomas Rahn
  • Patent number: 6433193
    Abstract: A process for production of tetrahydrofuran and gamma butyrolactone by hydrogenation of maleic anhydride recovered from a process of conversion of a n-butane.
    Type: Grant
    Filed: August 1, 2001
    Date of Patent: August 13, 2002
    Assignee: BASF Aktiengesellschaft
    Inventors: Aldo Bertola, Take Constantinescu, Philippe Raucq, Salvatore Cassarino
  • Publication number: 20020077489
    Abstract: Mint lactone can be prepared by hydrogenating hydroxymenthofurolactone to give the intermediate dihydrohydroxymenthofurolactone with the subsequent elimination of water.
    Type: Application
    Filed: October 19, 2001
    Publication date: June 20, 2002
    Inventors: Oskar Koch, Walter Kuhn
  • Patent number: 6395724
    Abstract: Disclosed are multibinding compounds which inhibit cyclooxygenase-2 (COX-2), an enzyme which catalyzes the first committed step in the biosynthesis of prostaglandins. The multibinding compounds of this invention containing from 2 to 10 ligands covalently attached to one or more linkers. Each ligand is a moiety capable of binding to COX-2. The multibinding compounds of this invention are useful in the treatment inflammation, pain, fever and the like.
    Type: Grant
    Filed: June 7, 1999
    Date of Patent: May 28, 2002
    Assignee: Advanced Medicine, Inc.
    Inventors: J. Kevin Judice, Deborah L. Higgins, John H. Griffin
  • Patent number: 6391365
    Abstract: 3,6-Dimethyl-2(3H)-benzofuranone is a new, valuable flavor material. A process for its industrial-scale preparation was developed.
    Type: Grant
    Filed: April 23, 1999
    Date of Patent: May 21, 2002
    Assignee: Haarman & Reimer GmbH
    Inventors: Stefan Lambrecht, Horst Surburg, Matthias Güntert, Volkmar Koppe
  • Patent number: 6376539
    Abstract: The present invention relates to novel substituted bicyclic lactones, to processes for their preparation and to their use for the prevention and/or treatment of disorders caused by hyper- or hypofunction of the glutamatergic system, in particular of cerebral ischaemias, cranial cerebral trauma, states of pain or CNS-mediated spasms.
    Type: Grant
    Filed: July 14, 2000
    Date of Patent: April 23, 2002
    Assignee: Bayer Aktiengesellschaft
    Inventors: Andreas Stolle, Horst-Peter Antonicek, Stephen Lensky, Arnd Voerste, Thomas Müller, Jörg Baumgarten, Karsten von dem Bruch, Gerhard Müller, Udo Stropp, Ervin Horváth, Jean-Marie-Viktor de Vry, Rudy Schreiber