Abstract: A transdermal fluid delivery device includes a housing defining a longitudinal axis and having a proximal end and a distal end. The housing defines a passageway extending longitudinally therethrough. A fluid reservoir is disposed at the proximal end of the housing in communication with the passageway of the housing and is adapted for retaining a fluid therein. A base member is positioned at the distal end of the housing. A microneedle assembly including a plurality of microneedles extending distally therefrom is also provided. The microneedle assembly is selectively moveable with respect to the housing between a retracted position, wherein the microneedles are disposed within the housing, and an extended position, wherein the microneedles are advanced distally to penetrate the base member and extend distally therefrom for puncturing the patient's epidermis and delivering the fluid into the patient's bloodstream.

Abstract: Delivery devices and methods related thereto may be used in humans for spinal delivery of cells, drugs or vectors. The patient population may include patients with spinal traumatic injury, amyotrophic lateral sclerosis, multiple sclerosis, spinal ischemia and any other spinal neurodegenerative disorders which will require spinal cell, vector or drug delivery. Unlike conventional methods which require multiple injection sites to make multiple, localized substrate deliveries, the delivery devices and methods of the present invention may allow for multiple substrate delivery locations with homogeneous substrate delivery with a single injection site.

Abstract: Apparatus and methods are provided to access bone marrow at various target areas. Such apparatus may include an intraosseous device operable to penetrate bone at a selected target area and a depth limiter operable to control depth of penetration of the intraosseous device into bone and associated bone marrow. A manual driver and a guide may be included to optimize optimum insertion of the intraosseous device at a selected insertion site on a sternum.

Abstract: A syringe body/needle assembly and a method for producing such a syringe body/needle assembly are provided that if free of an organic adhesive bond.

Abstract: A system for deploying needles in tissue includes a controller and a visual display. A treatment probe has both a needle and tines deployable from the needle which may be advanced into the tissue. The treatment probe also has adjustable stops which control the deployed positions of both the needle and the tines. The adjustable stops are coupled to the controller so that the virtual treatment and safety boundaries resulting from the treatment can be presented on the visual display prior to actual deployment of the system.

Abstract: A medicated module comprising a connecting body configured for attachment to a drug delivery device. A first needle is fixed within the connecting body and an outer body operatively coupled to the connecting body. A needle guard operatively coupled to the outer body and a biasing member positioned between the outer body and needle guard. A second needle fixed within the outer body and a recess within the connecting body defines a reservoir. The reservoir contains at least one dose of a medicament and is configured for fluid communication with the first and second needle.

Abstract: A gasket for use in a syringe so formed as to liquid-tightly and slidably contact an inner surface of an outer cylinder of the syringe, the gasket including a gasket body made of an elastic body and a coating layer formed on a portion thereof which contacts at least the syringe, wherein the coating layer includes a composition containing a silicone resin which comprises a condensate of a reactive silicone resin having a terminal silanol group and which has a siloxane bond derived from the silanol group, and does not contain solid fine particles.

Abstract: In accordance with at least one exemplary embodiment, a syringe device, a method and a system for delivering a therapeutic amount of ozone are disclosed. A sterility case can enclose a syringe portion and can maintain sterility while the syringe device is interfaced to an ozone generator. A valvably-controlled fluid channel can extend from a barrel of the syringe portion through the case. Conducting elements can be attached to the case and can breach the case. The conductive elements can be connected to electrodes. The electrodes can be attached to the syringe portion. The syringe portion can be filled with oxygen gas via the valvably-controlled fluid channel. An electric current can be provided to the conductive elements from the ozone generator resulting in a corona discharge from at least one of the electrodes. The therapeutic amount of ozone can be produced from the oxygen gas and the syringe portion delivered into a sterile field without compromise.

Abstract: An ear medication delivery device for delivering a treatment liquid and retaining the treatment liquid within an ear canal of a patient.

Abstract: Injection systems comprising a powered injector and one or more hazardous agents are disclosed.

Abstract: An injection device (1) for administering a fixed dose of a medication is provided. The injection device (1) comprises a housing (2) wherein a drive mechanism comprising a drive member (3) is at least partially enclosed and a dosing element (34) which is fixed relative to the drive member (3). Here, a dose can be set by rotating the dosing element (34) relative to the housing (2) in a dose setting direction (s) and the dose can be dispensed by pushing the dosing element (34) towards the housing (2). Moreover, a method is provided for operating an injection device (1) for the administration of a fixed dose of a medication: A dose can be set by rotating a dosing element (34), a dose can be dispensed by pushing the dosing element (34) towards the housing (2) and a dose can be cancelled by rotating the dosing element (34) in a direction opposite to the dose setting direction (s).

Abstract: A simple method and device enabling a unit dose from a reservoir is provided. The dose is drawn into the reservoir and is then expelled from the device by depressing a plunger. The plunger has features which divide the dose into discrete intervals. As the plunger is moved during delivery, the features on the plunger and features connected to a barrel interact to provide for intermittent stops to the delivery. Other aspects of the device provide for reduced dead space, safety and selective interconnection with other devices. Thus, the device divides the dose.

Abstract: A Luer securement device comprising a Luer adapter having a septum and a catheter hood, the Luer adapter further having a wedge seal for receiving a base portion of a catheter. The Luer securement device further includes an inserter body in which is slidably housed a catheter threader having a probe which is configured to advance a base portion of a catheter through the septum thereby seating the base portion of the catheter into the wedge seal of the Luer adapter as a tip portion of the catheter is inserted into a patient. The catheter threader further includes a needle adapter having a needle which is threaded through the probe and the catheter to assist in inserting the catheter into the patient. Following insertion of the catheter, the catheter threader is retracted within the inserter body thereby withdrawing the needle from the catheter and shielding a sharpened tip of the needle within at least one of the inserter body and the catheter threader.

Abstract: A light for use with an oral anesthesia syringe that is received into a passageway of a barrel of the light. When the syringe is received into a first opening in a proximal end of the barrel's passageway, the needle of the syringe extends through a second opening at the proximal end of the barrel. At least one lamp and preferably a plurality of lamps at the distal end of the barrel illuminate the needle and the interior of a patient's mouth. A battery is included in the light for powering the lamps. The insertion of the syringe into the barrel closes a pair of contacts to cause the battery to power the lamps, or the battery may be removed to remove power from the lamps.

Abstract: A method for delivering medicament such as for ameliorating pain in a patient includes introducing an injector through a nasal passage of the patient into a region substantially medial and/or posterior and/or inferior to a sphenopalatine ganglion (SPG) of the patient; and delivering a medicament from the injector superiorly and/or laterally and/or anteriorly towards the SPG. A device for delivering a medicament to a patient in need thereof includes (a) an injector containing a first end configured to remain outside a nasal passage of the patient and a second end configured for entry into the nasal passage of the patient; and (b) an introducer configured for engagement with a nostril of the patient and containing a passageway configured for slidably receiving the injector. The injector is moveable between a storage position preceding the engagement and an engaging position pursuant to the engagement.

Abstract: Pure sodium chloride is dissolved in sterile distilled water to form a sterile pure saline solution. A hermetically sealed disposable spray container holds a single measured dosage of the solution for fully rinsing and cleansing a nasal passageway. The measured dosage is sufficient for rinsing and cleansing the nasal passage and harmless if the measured dosage mistakenly enters the lungs or sinuses or stomach of the user.

Abstract: Disposable items made from bioplastic resins include a biodegradable resin; and a plasticizer; wherein the resin and plasticizer are intermixed to provide a generally homogenous bioplastic that is formed to provide the device. A disposable device includes a multidose syringe, a specimen tube, a scalpel, a lancet, a sharps container, or a suction canister. A method of disposing of an item includes providing an item made from a biodegradable resin and a plasticizer that are intermixed to provide a generally homogenous bioplastic; sterilizing the item utilizing radiation or ethylene oxide gas; shredding the item; and composting the item into a compost end product, thereby disposing of the item.

Abstract: A device including a first member extending along an axis. The first member includes an inner surface defining a cavity extending through a first surface and an opposite second surface and a side surface extending between the first and second surfaces. The inner surface defines an opening extending that is in communication with the cavity. A pivoting member is disposed in the cavity and includes an inner surface defining a passageway having a second member disposed therein. An engaging member is disposed in the opening. The pivoting member is movable between a first orientation such that the engaging member is spaced apart from the pivoting member and the pivoting member is rotatable to a selected trajectory relative to the longitudinal axis and a second orientation such that the engaging member engages the pivoting member and the second member is fixed in the selected trajectory. Methods of use are disclosed.

Abstract: A dose setting mechanism for a medicament delivery device is presented having a pinion mounted to a locking member where the axis of rotation of the pinion is offset and parallel to the longitudinal axis of the housing containing the dose setting components. Primary and secondary dose members are engaged with the pinion to indicate a set dose of medicament.

Abstract: An injection device has a dispensing chamber housing, a plunger, and a temperature control device. The dispensing chamber housing has a first part and a second part. The first part is thermally coupled to a needle. The second part is thermally coupled to the first part. The second part has an inner surface and an outer surface. The inner surface partially defines a dispensing chamber for holding a quantity of a substance. The plunger is engaged with an inner surface of the dispensing chamber housing, is capable of sliding in the dispensing chamber housing, and is fluidly sealed to the inner surface of the dispensing chamber housing. The temperature control device at least partially surrounds the dispensing chamber housing and is capable of altering a temperature of the substance in the dispensing chamber. The second part has a greater thermal coefficient than the first part.

Abstract: A syringe for use with a powered injector to inject a fluid into a patient that includes a length of material adapted to transmit or propagate electromagnetic energy therethrough. The length of material includes at least a first indicator positioned along the length of material. The first indicator is adapted to interact with at least a portion of the energy being propagated through the length of material in a manner that is detectable. The presence (or absence) of the first indicator provides or corresponds to information about the syringe configuration. The indicator(s) of the present invention can, for example, provide information about syringe configuration by the number and/or position thereof. A plurality or set of such syringes can be provided, with the configuration of each such syringe being represented by the presence or absence of indicator(s) of that syringe.

Abstract: A refillable and implantable infusion apparatus and method that includes a needle penetration detector that detects and indications the position of a needle relative to a septum of a drug reservoir of the implantable infusion apparatus. With the needle position data, medical professionals may better ensure they are injecting drugs into the drug reservoir, thus, improving patient safety.

Abstract: Syringe assemblies comprising a disinfecting reservoir collar to ensure adherence to aseptic techniques for use in flush procedures for vascular access devices (VAD's) are described. The syringe assemblies include a plunger rod, a syringe barrel, and reservoir collar that permits disinfection of a hub of a VAD connector upon connection to the reservoir collar. Also described are methods of disinfecting vascular access devices.

Abstract: An apparatus for administering a therapeutic is provided. In various embodiments, the apparatus includes a syringe having a barrel and a plunger and having an ozone generator associated therewith. The generator is initiated and a therapeutic gas is accumulated within the barrel, at which point it can be delivered from the barrel into a target site via a needle, thereby delivering therapeutic effects to that target site.

Abstract: Syringes and methods of using are described which protect materials within the syringe barrel cavity from contaminants and photo-chemical degradation. A syringe is provided having an inspection window for viewing medications or other materials within the cavity of a syringe barrel. The syringe barrel and other syringe components may be colored, opaque, darkened, amber, tinted; or the syringe barrel may have applied thereto polarizing filters; or materials having light polarizing properties can be used to manufacture the syringe barrel and other syringe components of the syringe to cancel particular components of light.

Abstract: An injection syringe, having a syringe cylinder, a plunger rod inserted therein and connected to a stopper by way of a coupling part, and a module that is provided in the proximal end of the syringe cylinder and having a cannula, mounted in a cannula holder received in a guided sleeve, and a sealing insert for the fluid-tight closure of the proximal end of the syringe cylinder and a protection cap for protecting the cannula, wherein the protective cap on the inner circumference has ribs extending in an axial direction, which engage in corresponding grooves of the driving part for a rotary drive thereof, and wherein in the sealing insert a hollow space is formed, which is closed on the proximal side and on the distal side transitions into an opening, by way of which a tip of the coupling part can be coupled to the hollow space.

Abstract: Embodiments of a retractable syringe assembly are provided that include a dual syringe barrel configuration. In one or more embodiments, the assemblies include a fluid barrel for retaining fluid and a retraction barrel for housing the retraction feature and the needle hub assembly. The assemblies include a trigger element that moves with the plunger rod to activate the retraction feature within the retraction mechanism.

Abstract: A prefilled syringe for injecting medicament into a patient includes a barrel constructed of a polymeric material, a cannula and a hub. The barrel has a diameter, a longitudinal axis, a proximal end and a distal end. The cannula has a proximal end and a tip opposite the proximal end. The proximal end of the cannula is fixed to the distal end of the barrel. The cannula is positioned generally coaxially with the longitudinal axis. The hub is integrally formed with the distal end. The hub includes a rib section and a cap. The rib section has a generally cruciform cross-section taken along a rib plane. The rib plane is generally perpendicular to the longitudinal axis. The cap has a generally U-shaped cross-section taken along a longitudinal plane. The longitudinal plane is generally parallel to the longitudinal axis.

Abstract: A portable medicament dispensing device having a mechanism which is not susceptible to jamming for dispensing the medication to a user. The device employs a coupling for coupling the relative motion between reciprocating body members housing the ancillary components and a barrel plunger associated with the syringe. One embodiment provides a pivoting coupling whereas an alternate uses a rack and pinion system. The advantage of simplifying such mechanisms results in a structure which has smooth unencumbered motion with fewer parts to avoid mechanical jamming during use.

Abstract: A flushing device (8) usable in the catheterization of a bladder includes a flexible container (9) defining a compartment (12) adapted to be filled with a liquid, and a connector (10) attached to the container (9). The connector (10) is adapted to be connected to a catheter, and the connector (10) is provided with an opening (11). The flexible container (9) is interconnected with the connector (10) via a lumen (13), such that liquid is allowed to pass through the connector (10) in the lumen (13) from the flexible container (9) and exit through the opening (11). The flexible container further includes a non-return valve (14) arranged in the lumen (13). A kit including such flushing device (8) is also described.

Abstract: A medical aspiration apparatus for removing the contents of a subject's stomach includes a nasogastric (NG) tube having a tip structure that is less likely to be obstructed by stomach mucosa and solid particles of the stomach's contents. The apparatus also includes a flow control manifold that is capable of quickly and easily alleviating obstructions.

Abstract: An injection device with a housing and an operating element or coupling element mounted in the housing in such a way that the operating element or coupling element may be retained in a first position by a first holding connection and may be displaced into a second position that is axially offset relative to the first position after introducing an ampoule. In some embodiments, the operating element or coupling element may be retained by a second holding connection in the second position.

Abstract: Medicament devices include a sealed medicament dose container comprising a cell based medicament that is stored at a temperature less than about ?40 degrees Celsius, then thawed into a liquid prior to administration and a medicament dose cartridge configured and sized to snugly hold the dose container therein during extraction of the liquid medicament. Related dose containers, retainers and extraction/dispensing systems are also described.

Abstract: A drug transfer assembly including a connector connectable to a portion of an intravenous line adapted for connection to a patient's bloodstream and an adapter cap removably connectable with the connector is disclosed. The connector is formed of a rigid material and the adapter cap is formed of a pliable material. With the adapter cap connected to the connector, the adapter cap protectively surrounds and shields the connector. The adapter cap provides a cushioning surface which prevents rubbing of the connector against the skin of a patient. In this manner, the adapter cap prevents the connector of a drug transfer assembly from causing irritation and/or infection to the skin of a patient. Furthermore, the adapter cap provides a protective shield which prevents the connector of a drug transfer assembly from becoming contaminated with undesirables.

Abstract: An injector device includes an injector body that receives a syringe; and an injection assembly being configured to dispense medicament from the syringe in a dispensation step. Certain types of injector devices include a sudden completion indicator that indicates when the injection is completed. Certain types of injector devices are configured to dispense two different medicament formulations having different viscosities from syringes without making any changes to the injector devices other than to switch out the syringes. Certain types of injector devices include safety arrangements that inhibit firing of the injector device until front and rear housing assemblies are disposed in predetermined rotational and axial positions relative to each other.

Abstract: A syringe drive device drives a syringe including a cylindrical cylinder and a piston. The cylinder includes a solution supply port at one end, and an opening at the other end. The piston is inserted into the cylinder through the opening. The syringe drive device includes a cylinder holder to rotatably hold the cylinder of the syringe, and a piston driver to drive the piston in its axial direction with respect to the cylinder held in the cylinder holder.

Abstract: A direct stream hydrodynamic catheter system is provided for the removal of thrombus, lesions and the like including provisions for the infusion of drugs, lysing fluids and the like into a blood vessel. Physician controlled high powered direct fluid jet streams emanate from a fluid jet emanator in the form of robust radially directed fluid jet streams to impinge upon and ablate difficult and strong thrombus or lesions within a blood vessel. Effluent aspiration is controlled by an exhaust regulator in the form of a roller pump, but effluent removal can be assistingly influenced by the fluid pressure associated with the radially directed fluid jet streams.

Abstract: A medical injection system includes an elongate injection apparatus and an actuator apparatus. The actuator apparatus includes a fitting for coupling the actuator apparatus to a delivery catheter and a reversible gripping means to grip the injection apparatus; the gripping means is included in a plunger that is slideably engaged with the fitting and directs the injection apparatus through a fitting lumen and through a catheter lumen, when the fitting is coupled to the catheter.

Abstract: A syringe assembly having a collapsible or pivotable plunger rod with magnification properties is provided. In a pre-use or packaged state, the plunger rod is positioned substantially parallel to a barrel of the syringe assembly resulting in the syringe assembly having a reduced length and a smaller packaging footprint. The smaller packaging footprint allows for reduced storage space of the syringe assembly. Upon removal from a packaging and/or a storage space, the plunger rod can be slid or pivoted toward a proximal end of the syringe barrel and locked into place such that the syringe assembly is ready for use. The plunger rod can be shaped to provide magnification to indicia of the syringe barrel and/or contents. Alternatively, a separate magnification member can be associated with the plunger rod and/or secured about the syringe barrel.

Abstract: A syringe assembly includes a syringe barrel having an exterior surface, an inside surface defining a chamber, an open proximal end, a distal end, and an outlet disposed adjacent the distal end in fluid communication with the chamber; and a plunger assembly disposed at least partially within the syringe barrel. The plunger assembly includes an elongated plunger rod and a plunger head. The elongated plunger rod is associated with the plunger head to move the plunger head within the chamber of the syringe barrel through an injection cycle. The plunger rod is adapted to move from a collapsed position extending alongside the exterior surface of the syringe barrel to an extended position engaging the plunger head to move the plunger head through the injection cycle.

Abstract: In various embodiments, an ophthalmic injection device may include a dispensing chamber, a first thermal sensor coupled to the dispensing chamber, a temperature control layer coupled to the dispensing chamber, a second thermal sensor coupled to the dispensing chamber, and a first processing device. The first processing device may be configured to receive temperature information from the first thermal sensor and the second thermal sensor and control the temperature control layer using the received temperature information. In some embodiments, the first processing device may receive temperature information directly from the second thermal sensor (e.g., in analog form) and may compare the temperature information from the first thermal sensor (e.g., received from the second processing device in digital form) and the second thermal sensor to detect temperature offsets between the two sensors.

Abstract: A plunger-driven delivery device for use with a feeding tube for delivering an ingestible material to a user is provided. The delivery device includes a device body having a first chamber, a second chamber and an exit orifice through which the ingestible material is delivered to the feeding tube. A first plunger is disposed in the first chamber, and a second plunger is disposed in the second chamber. The delivery device can be provided with the ingestible material disposed in the first chamber and a flushing liquid disposed in the second chamber. The delivery device is operable to provide sequential delivery first of the ingestible material and then the flushing liquid into the feeding tube. In some embodiments, a mechanical interlock is disposed between the first and second plungers to prevent use of the second plunger until the first plunger has been depressed.

Abstract: Apparatus for use with tissue (22) of a subject, including a substance (24) configured to be injected into the tissue, and first and second tissue-squeezing surfaces (20) configured to be placed on first and second sides of the tissue, to exert pressure on the tissue by being moved toward each other in response to a squeezing force (F), and to facilitate injection of the substance into the tissue by releasing the substance in response to application of the squeezing force.

Abstract: A dosing assembly (204) and/or a container (202) comprising fastening means (206,208) for fastening the container to the dosing assembly, the fastening means of the dosing assembly and/or the container defining an asymmetrical pattern in a plane transverse to an axial direction of the dosing assembly and/or a container.

Abstract: The device is essentially a pipette with pre-filled medication in it. Also, there is an additional plug with pressure release valves on the tip of the pipette. The pre-filled medication prevents licensed practitioners from having to count drops and having to fill the pipette up, thus saving time. The plug on the tip fits snuggly into the ear canal helping the practitioner find the perfect spot in the ear canal. Pressure relief valves in the plug helps relieve pressure in the ear canal when delivering treatment, helping for a safer treatment. The plug on the tip of the pipette also has openings on the side to deliver treatment thus coving a wider spectrum of the ear canal, and creating a more beneficial treatment.

Abstract: Devices for delivery of medical compositions in either liquid or powder form include a piercing device for piercing a flexible sheet material in which when contained in a flexible blister dosage form, the piercing device serves as a delivery channel for compositions contained in the blister. The device is configured to reduce or inhibit puncture flap interference with the delivered spray or mist by forming a substantial non-contact drape in the material prior to puncture.

Abstract: Various embodiments of drug delivery devices and methods of assembling such devices are provided. In one embodiment, a drug delivery device for dispensing medicament comprises a medicament cartridge, wherein the cartridge comprises (i) a distal end, (ii) a proximal end that is opposite the distal end along a body axis of the cartridge, and (iii) a movable piston arranged substantially at the proximate end of the cartridge. The drug delivery device further comprises a piston rod having a distal end for axially moving the piston in the distal direction during dispensing of a set dose of medicament, wherein a relative axial distance between the distal end of the piston rod and a proximal face of the piston is set during assembly of the drug delivery system. The relative axial position between may be set such that the piston rod and the proximal face of the piston abut each other.

Abstract: The present invention generally relates to systems for deploying intraocular shunts without the use of an optical apparatus that contacts an eye, such as a goniolens. In certain embodiments, systems of the invention include a locking mechanism, and a device configured to hold and deploy an intraocular shunt, in which a distal portion of the device is movable within a proximal portion of the device and the distal portion of the device is configured to mate with the locking mechanism to prevent movement of the distal portion when the locking mechanism is engaged.

Abstract: Injection systems comprising a powered injector and one or more hazardous agents are disclosed.

Abstract: The present invention concerns a prefilled injection device having a container and a dose setting mechanism encapsulated inside the housing. The housing is made from two parts which are locked together by a bayonet coupling: In addition to the bayonet coupling, the two parts are also provided with irreversible locking means locking the two parts permanently together.