Abstract: A system and method for preventing or reducing unwanted heat in a microfluidic of the device while generating heat in selected regions of the device. In one example, current is supplied to a heating element through electric leads, wherein the leads are designed so that the current density in the leads is substantially lower than the current density in the heating element. This maybe accomplished using conductive leads which have a cross-sectional area which is substantially greater than the cross-sectional area of the heating element. In another example, unwanted heat in the microfluidic complex is reduced by thermally isolating the electric leads from the microfluidic complex. This maybe accomplished by running each lead directly away from the microfluidic complex, through a thermally isolating substrate. After the leads pass through the thermally isolating substrate, they are then routed to the current source.

Abstract: In some embodiments, the present invention is directed to processes for the combination of injecting charge in a material electrochemically via non-faradaic (double-layer) charging, and retaining this charge and associated desirable properties changes when the electrolyte is removed. The present invention is also directed to compositions and applications using material property changes that are induced electrochemically by double-layer charging and retained during subsequent electrolyte removal. In some embodiments, the present invention provides reversible processes for electrochemically injecting charge into material that is not in direct contact with an electrolyte. Additionally, in some embodiments, the present invention is directed to devices and other material applications that use properties changes resulting from reversible electrochemical charge injection in the absence of an electrolyte.

Abstract: In some embodiments, the present invention is directed to processes for the combination of injecting charge in a material electrochemically via non-faradaic (double-layer) charging, and retaining this charge and associated desirable properties changes when the electrolyte is removed. The present invention is also directed to compositions and applications using material property changes that are induced electrochemically by double-layer charging and retained during subsequent electrolyte removal. In some embodiments, the present invention provides reversible processes for electrochemically injecting charge into material that is not in direct contact with an electrolyte. Additionally, in some embodiments, the present invention is directed to devices and other material applications that use properties changes resulting from reversible electrochemical charge injection in the absence of an electrolyte.

Abstract: The present invention provides a test strip for measuring a concentration of an analyte of interest in a biological fluid, wherein the test strip may be encoded with information that can be read by a test meter into which the test strip is inserted.

Abstract: In an apparatus for producing acidic electrolyzed water, the use of a protection membrane having slits or other discontinuities allows the protection of a permeable membrane, such as an anion-permeable or anion-selective membrane, from chlorine generated by the electrolysis. The protection membrane further preserves the electrical conductivity of the membrane and electrode assembly, because of a venting action of trapped gas and fluid through the slits. The protection membrane is useful both in three chambered electrolyzers and in two chambered electrolyzers. The preferred protection membrane has slits formed by overlapping strips of fabric or the like. The preferred fabric is a non-woven fabric.

Abstract: The present invention is directed to devices and methods for carrying out and/or monitoring biological reactions in response to electrical stimuli. A programmable multiplexed active biologic array includes an array of electrodes coupled to sample-and-hold circuits. The programmable multiplexed active biologic array includes a digital interface that allows external control of the array using an external processor. The circuit may monitor, digitally control, and deliver electrical stimuli to the electrodes individually or in selected groups.

Abstract: An anode and cathode for an electrolytic cell are configured as a low inductance transmission line to enable control of an interphase at an electrode surface. The anode and cathode are coupled to a switched current source by a low inductance path that include a parallel plate transmission line, a coaxial transmission line, or both. The switched current source provides switching between current sources at three or more voltages to provide fast charging and discharging of the double-layer capacitance associated with the electrode surface.

Abstract: The present invention relates to an analyzing instrument (1A) which includes a capillary (31), a fluid feed port (20) for introducing a sample liquid to the capillary (31), and a fluid feed promoter (6) for promoting the introduction of the sample liquid into the feed port (20). The capillary (31) of the analyzer (1A) may be formed on a substrate (2) for example. The fluid feed promoter (6) may include at lease one of a water-absorbing layer having a higher water-absorbing capacity than the substrate (2) and an adhesive layer having a greater adhesion to the skin than the substrate (2).

Abstract: A taste recognizing device has a sensor body and a touch panel. The sensor body includes a sensor part with a sensor probe for measuring taste by means of a molecular film which outputs an electrical signal presenting taste information representing at least one kind of taste, a solution insertion part having insertion sections which are arranged circumferentially at predetermined intervals and in which a solution whose taste is to be measured, a reference taste measurement solution and a cleaning solution are selectively inserted, and an arm drive part for moving the sensor part relative to a predetermined insertion section of the solution insertion part. On the basis of the electric signal outputted from the sensor probe and presenting the taste information, at least measurement for taste recognition of the solution whose taste is to be measured is made possible.

Abstract: In order for electrical feeds (2, 3) of an electrical supply unit for material (1) to be treated, in a device for the electrochemical treatment thereof, to be protected against metal deposition, it is proposed that at least one electrically insulating shell (7, 8) should be provided, which encloses the at least one electrical feed (2, 3), over a particular length starting from contact means (12) for making contact with the material to be treated, so that no metal deposit of more than 0.04 mm is formed on the blank parts of the electrical feed when the electrical feed (2, 3) is immersed up to this particular length in a liquid during the electrochemical treatment of the material (1) to be treated.

Abstract: A sample plate assembly for an electrophoresis apparatus including a tray at a sample supply portion of a capillary array, an adapter for the tray, a sample plate mounted on the adapter, a septer mounted on the sample plate and a septer holder mounted on the septer. Thereby, many number of samples can be automatically supplied to capillaries in a multi capillary array.

Abstract: A conductive planarization assembly for use in electrochemical mechanical planarization is provided. A conductive planarization assembly in accordance with an exemplary embodiment of the invention comprises a first insulating member and a second insulating member overlying the first insulating member and having a plurality of first holes. A conductive member is interposed between the first insulating member and the second insulating member and is electrically coupled to an external circuit. The conductive member comprises a plurality of cathode regions that are exposed by the plurality of first holes of the second insulating member.

Abstract: Embodiments of the invention provide a method for plating copper into features formed on a semiconductor substrate. The method includes positioning the substrate in a plating cell, wherein the plating cell includes a catholyte volume containing a catholyte solution, an anolyte volume containing an anolyte solution, an ionic membrane positioned to separate the anolyte volume from the catholyte volume, and an anode positioned in the anolyte volume. The method further includes applying a plating bias between the anode and the substrate, plating copper ions onto the substrate from the catholyte solution, and replenishing the copper ions plated onto the substrate from the catholyte solution with copper ions transported from the anolyte solution via the ionic membrane, wherein the catholyte solution has a copper concentration of greater than about 51 g/L.

Abstract: The invention relates to a spectrophotometric measuring cell, useful for automated reagent mixing and for handsfree physical cleansing comprising: a measuring cell; a shaker; and an actuator. The invention also relates to a method for automatically mixing of fluids and/or reagents and for handsfree physical cleansing of the inner core of spectrophotometric measuring cells.

Abstract: In electric plating of supplying a current between an anode electrode and a cathode electrode as a plated body immersed in a plating solution thereby forming a plated film comprising a conductor on a surface of the cathode electrode, a preliminary electrolytic electrode that comes in contact with the plating solution before the cathode electrode comes in contact with the plating solution is disposed, and the cathode electrode is brought into contact with the plating solution while supplying a preliminary electrolytic current between the preliminary electrolytic electrode and the anode electrode, whereby a uniform plated film with no voids can be formed while suppressing dissolution of the underlying conductive film in the electric plating treatment.

Abstract: A novel label-free sensitive detection method by employing a novel sensitive charge sensor is provided. Dissociation constant information is provided by a simple measurement of the dissociation of the target molecule form the target's receptor. The later process is affected by a novel system and its configuration as described herein. Basic objectives are to provide a drug discovery and characterization system that is an improvement over the current state of the art, low cost, highly sensitive, accurate, fast and easy to use. This invention involves both a physical system and a methodology.

Abstract: Sensors for the electro-chemical analysis of samples and methods for the manufacturing of sensors allow for more efficient manufacture and use of electro-chemical sensors. Flexible sheets, such as polycarbonate sheets, are used to easily manufacture sensor components, with sensor chemistry being applied to the sensor components at manufacture. Sensors may be manufactured with modular components, enabling easy production-line manufacture and construction of electro-chemical sensors with significant cost savings and increased efficiency over existing sensor styles and sensor manufacturing techniques.

Abstract: The present invention provides a method by which a metal-fog-forming metal dissolved in one portion of “a molten salt mixture consisted of one or more of metal-fog-forming metal containing molten salts” (generally, a molten salt) can be removed and transferred to another portion of the molten salt to increase the concentration thereof. The method can hence be utilized as one of means for treating molten salts in various industrial fields in which metal-fog-forming metal-containing molten salts such as Ca or Na are handled. In particular, when the method is utilized in producing Ti by Ca reduction, the Ca dissolved in the molten salt to be fed to an electrolytic cell can be rapidly removed (recovered) and the Ca formation efficiency during the electrolysis of the molten salt can be enhanced. Consequently, Ca formation and TiCl4 reduction in the electrolysis of the molten salt can be efficiently carried out and a stable operation on a commercial scale is possible.

Abstract: The present invention relates to a method for the deactivation and/or destruction of hazardous materials such as chemical or biological agents. The invention further relates to apparatus for treating hazardous material and for decontaminating items that may have come into contact with it, the apparatus comprising a treatment vessel or chamber and a light source capable of irradiating a catalyst within the treatment vessel or chamber with a predetermined wavelength of light.

Abstract: A system, method, and device are described for ultrasonic treatment of viscous fluids, including, e.g., crude oils that provide a variety of desired modifications. The invention includes a container having a circumvolving outer wall configured to allow passage of a quantity of a material within a passageway therein and ultrasonic transducers that attach to and circumvolve the outer wall of the container. The ultrasonic transducers transmit ultrasonic energy into material within the container at preselected frequencies thereby achieving desired effects.

Abstract: A fluid sensor is constructed to has a pair of electrodes whereas between electrodes there are not additional materials designated to adsorb analytes if their concentrations are high, or there are absorbents if the analyte concentrations are low. An alternating current voltage of varying frequencies is applied to the electrodes of the sensor by an alternative current device. In return, it detects electrical properties such as impedance and its components, reactance, resistance, and phase angles of the sensor with analytes whereas the analytes reside in or pass through the electrode at each frequency. Thus a spectrum of electrical property of the analyte can be established at various applied frequencies. The electrical properties are analyzed by a pattern recognition process, and compared with those of the known fluid. Therefore, the fluid can be detected and identified. A reference sensor is provided with the same configuration of the fluid sensor.

Abstract: The assay devices, assay systems and device components of this invention comprise at least two opposing surfaces disposed a capillary distance apart, at least one of which is capable of immobilizing at least one target ligand or a conjugate in an amount related to the presence or amount of target ligand in the sample from a fluid sample in a zone for controlled fluid movement to, through or away the zone. The inventive device components may be incorporated into conventional assay devices with membranes or may be used in the inventive membrane-less devices herein described and claimed. These components include flow control elements, measurement elements, time gates, elements for the elimination of pipetting steps, and generally, elements for the controlled flow, timing, delivery, incubation, separation, washing and other steps of the assay process.

Abstract: An apparatus for electropolishing a conductive layer on a wafer using a solution is disclosed. The apparatus comprises an electrode assembly immersed in the solution configured proximate to the conductive layer having a longitudinal dimension extending to at least a periphery of the wafer, the electrode assembly including an elongated contact electrode configured to receive a potential difference, an isolator adjacent the elongated contact electrode, and an elongated process electrode adjacent the isolator configured to receive the potential difference, a voltage supply is configured to supply the potential difference between the contact electrode and the process electrode to electropolish the conductive layer on the wafer.

Abstract: Clip devices contemplated herein comprise a metal-containing base, wherein the base comprises a lower clip body and an upper clip body, and wherein the lower clip body further comprises at least two sets of electrically conducting wire springs. Contemplated electrically conducting wire springs comprise at least one non-contact body section and a plurality of contact points.

Abstract: Embodiments of the invention are directed to apparatus, methods, and applications involving the actuation of a semi-insulative working fluid by electromechanical forces based on electrowetting-on-dielectric (EWOD) and liquid dielectrophoresis (liquid DEP) mechanisms that are controlled by the frequency, but not the magnitude, of an AC voltage (i.e., ‘frequency-addressable). In the various apparatus embodiments of the invention, a single, frequency-addressable electrode pair includes at least one electrode that has a spatially-varying dielectric coating thickness and thus a spatially-varying electrode gap wherein at least a portion of which a volume of a working fluid can stably reside under no influence of an applied voltage. In an exemplary aspect, a frequency-addressable, bistable apparatus includes at least one wider gap and one narrower gap associated, respectively, with a thicker and a thinner dielectric coating thickness of the electrode(s).

Abstract: Apparatus and methods are disclosed for using an ultraviolet laser system to decompose selected chemical substances in water. More particularly, this invention provides methods and apparatus whereby various environmental pollutants in water are rapidly decomposed to very low concentrations, consistent with environmental discharge regulations, use requirements, and/or applicable health standards, by means of exposure to ultraviolet laser irradiation (10, 20), either with or without one or more catalysts and/or other chemical additives to facilitate or enhance the decomposition process.

Abstract: A method and device for ion beam processing of surfaces of a substrate positions the substrate to face an ion beam, and a new technologically-defined pattern of properties is established. According to the method, the current geometrical effect pattern of the ion beam on the surface of the substrate is adjusted depending on the known pattern of properties and the new technologically-defined pattern of properties, and depending upon the progress of the processing, by modifying the beam characteristic and/or by pulsing the ion beam. A device for carrying out the method includes a substrate support for holding at least one substrate, which can be moved along an Y-axis and an X-axis, and an ion beam source for generating an ion beam, which is perpendicular to the surface to be processed of the substrate in the Z-axis or which may be arranged in an axis, inclined in relation to the Z-axis. The distance between the ion beam source and the surface to be processed of the substrate may be fixed or variable.

Abstract: Provided is a method for determining a zeta potential generated between a solid wall and a solution. The method includes (a) injecting an electrolyte solution into a first inlet of a T channel, which is provided with first and second inlet electrodes and a grounded outlet electrode, and a mixed solution of the electrolyte solution and a fluorescent dye into a second channel of the T channel and maintaining a steady-state of the two solutions; (b) applying a direct current electric field from the first and second electrodes to the outlet electrode to form an interface between the electrolyte solution and the mixed solution; (c) applying an alternating current electric field from one of the two inlet electrodes to the outlet electrode to oscillate the interface; and (d) measuring an amplitude of oscillation of the interface and determining the zeta potential from the standard relationship between the zeta potential and the amplitude.

Abstract: A system and method for preventing or reducing unwanted heat in a microfluidic of the device while generating heat in selected regions of the device. In one example, current is supplied to a heating element through electric leads, wherein the leads are designed so that the current density in the leads is substantially lower than the current density in the heating element. This may be accomplished using conductive leads which have a cross-sectional area which is substantially greater than the cross-sectional area of the heating element. In another example, unwanted heat in the microfluidic complex is reduced by thermally isolating the electric leads from the microfluidic complex. This may be accomplished by running each lead directly away from the microfluidic complex, through a thermally isolating substrate. After the leads pass through the thermally isolating substrate, they are then routed to the current source.

Abstract: The present invention relates to a system and method for moving samples, such as fluid, within a microfluidic system using a plurality of gas actuators for applying pressure at different locations within the microfluidic. The system includes a substrate which forms a fluid network through which fluid flows, and a plurality of gas actuators integral with the substrate. One such gas actuator is coupled to the network at a first location for providing gas pressure to move a microfluidic sample within the network. Another gas actuator is coupled to the network at a second location for providing gas pressure to further move at least a portion of the microfluidic sample within the network. A valve is coupled to the microfluidic network so that, when the valve is closed, it substantially isolates the second gas actuator from the first gas actuator.

Abstract: The invention is directed to devices and methods that allow for simultaneous multiple biochip analysis. The method of analyzing the plurality of biochips includes inserting a first biochp into a first station of an analysis device, inserting a second biochip into a second station of the analysis device, wherein each of the first and second biochips include a substrate, the substrates including an array of detection electrodes, each electrode including a different capture binding ligand, a different target analyte, and a label, and a plurality of electrical contracts, detecting current as an indication of the presence of the labels on the first biochip, and detecting current as an indication of the presence of the labels on the first second biochip. The devices and method may be used with multiple cartridges comprising biochips comprising arrays, such as nucleic acid arrays, and allow for high throughput analysis of samples.

Abstract: The present invention is directed to devices and methods for carrying out and/or monitoring biological reactions in response to electrical stimuli. A programmable multiplexed active biologic array includes an array of electrodes coupled to sample-and-hold circuits. The programmable multiplexed active biologic array includes a digital interface that allows external control of the array using an external processor. The circuit may monitor, digitally control, and deliver electrical stimuli to the electrodes individually or in selected groups.

Abstract: A biological material detection apparatus which detects a charged biological material such as a gene or protein contained in a sample liquid is disclosed. A biological material detection element includes a substrate, at least one first electrode formed on the substrate, and a plurality of second electrodes which are arrayed at predetermined intervals around the first electrode on the substrate along the circumferential direction and to which ligands that react with predetermined biological materials are respectively immobilized. A sample liquid is introduced toward the first electrode on the substrate. The introduced sample liquid is moved radially toward the second electrodes by electrical control.

Abstract: An apparatus integrates one dimensional separation to another dimensional separation and automates the operation of the two dimensional separation. The first dimensional separation is performed in one column while the second dimensional separation is performed in multiple separation columns. The integration is achieved using a one-piece, a two-piece, or a three-piece interface.

Abstract: In order to be capable of a chemical reaction, analysis or the like wherein a small amount of samples is used, a reactor comprises a flat plate-like first substrate the inside of which is provided with a heating means; and a flat plate-like second substrate, which is placed on the top of the above-described first substrate, and on a surface thereof to be placed on the top of the above-described first substrate a flow channel having a predetermined contour has been defined.

Abstract: A device for fabricating a high-density microarray for cDNA or protein having an arbitrary pattern comprises an electrospray part for electrostatically spraying solutions containing a plurality of kinds of biologically active samples one by one, a support part supporting sample chips on which samples in the solutions sprayed from the electrospray part are deposited, a mask part disposed between the electrospray part and the support part and having holes the number of which is the same as that of the sample chips so as to selectively deposit the samples simultaneously in the adequate positions corresponding to the sample chips, a moving part for fabricating microarrays at a time by relatively moving the sample chip support part and the mask part and depositing the samples on the sample chips. Therefore the device can fabricate a large number of inexpensive high-density microarrays.

Abstract: A variety of elastomeric-based microfluidic devices and methods for using and manufacturing such devices are provided. Certain of the devices have arrays of reaction sites to facilitate high throughput analyses. Some devices also include reaction sites located at the end of blind channels at which reagents have been previously deposited during manufacture. The reagents become suspended once sample is introduced into the reaction site. The devices can be utilized with a variety of heating devices and thus can be used in a variety of analyses requiring temperature control, including thermocycling applications such as nucleic acid amplification reactions, genotyping and gene expression analyses.

Abstract: A structural system for accurately reproducible in situ x-ray studies of operating rechargeable electrochemical battery cell electrode components comprises an hermetically sealed cell component enclosure incorporating an x-ray transmissive window member of beryllium or the like. A research embodiment of the system comprises means for rapidly and consistently interchanging electrode compositions for operative comparison and evaluation, while a laminated cell system embodiment enables accurate testing of electrode components in commercial configurations such as unitary polymeric Li-ion battery cells.

Abstract: A cracking furnace for the pyrolysis heating of an organic feedstock includes a heating section and at least one convection section. In one embodiment the furnace includes first and second convection sections positioned along opposite sides of the heating section. The openings for admitting flue gas to the convection sections can be at the top or the bottom of the heating section. In another embodiment the furnace includes a plurality of passageways for the communication of flue gas from the heating section to the convection section. The passageways can be positioned at the top or the bottom of the heating section. The passageways provide a more even flow of flue gas through the heating section by preventing recirculation of the flue gas within the heating chamber.

Abstract: The present invention provides microfluidic devices, systems and methods for using the same, which facilitate the introduction of fluid to and from a microfluidic channel located within the microfluidic devices.

Abstract: An apparatus and method for converting methane to methanol by partial oxidation comprises a source of methane, a source of oxygen, and a capillary tube having an outflow end and an inflow end communicating with the sources of methane and oxygen. An anode is positioned proximate to but spaced from the capillary tube. A voltage source negatively biases the capillary tube relative to the anode. A plasma jet flows from the outflow end of the capillary tube. The methane partially oxidizes into methanol in a reaction zone in the plasma jet. A collector receives the methanol in the plasma jet for subsequent condensation, separation and purification.

Abstract: A device and a method for simply and accurately evaluating-performance of fuel cells have been provided. Hydrogen gas and carbon monoxide gas are caused to flow into a sample holder where an electrode catalyst sample is laid, and the amount of carbon monoxide gas discharged therefrom is detected. The amount of carbon monoxide gas adsorbed by the electrode catalyst sample is calculated based on the amount of supplied carbon monoxide gas and the amount of detected carbon monoxide gas. The output voltage of a fuel cell is calculated based on a correlation between calculated amounts of carbon monoxide gas adsorbed by the electrode catalyst and output voltages of the fuel cell.

Abstract: Intended for application on ducts through which flow a fluid at a high temperature, and particularly at a high pressure, comprising two bodies (4) and (8) which axially screw onto each other, one body (4) provided with a threaded neck (5) for attachment to the orifice of duct wall (3), which body (4) houses within it sensor element (2) of the probe which is thus placed inside the duct, with second body (8) screwed onto first body (4) and exerting on sensor element (2) the pressure required to secure it in its housing, with second body (8) further provided with an axial orifice through which passes a metallic tube (9) open to the exterior and which is provided with a metallic washer (10), soldered to said tube (9), which is separated from second body (8) by an electrically insulating washer (12).

Abstract: An electronic system for selectively detecting and identifying a plurality of chemical species, which comprises an array of nanostructure sensing devices, is disclosed. Within the array, there are at least two different selectivities for sensing among the nanostructure sensing devices. Methods for fabricating the electronic system are also disclosed. The methods involve modifiying nanostructures within the devices to have different selectivity for sensing chemical species. Modification can involve chemical, electrochemical, and self-limiting point defect reactions. Reactants for these reactions can be supplied using a bath method or a chemical jet method. Methods for using the arrays of nanostructure sensing devices to detect and identify a plurality of chemical species are also provided.

Abstract: A method and apparatus is provided for depositing and planarizing a material layer on a substrate. In one embodiment, an apparatus is provided which includes a partial enclosure, a permeable disc, a diffuser plate and optionally an anode. A substrate carrier is positionable above the partial enclosure and is adapted to move a substrate into and out of contact or close proximity with the permeable disc. The partial enclosure and the substrate carrier are rotatable to provide relative motion between a substrate and the permeable disc. In another aspect, a method is provided in which a substrate is positioned in a partial enclosure having an electrolyte therein at a fist distance from a permeable disc. A current is optionally applied to the surface of the substrate and a first thickness is deposited on the substrate. Next, the substrate is positioned closer to the permeable disc and a second thickness is deposited on the substrate.

Abstract: Fixed volumes of samples are metered into the reaction channel of a microfluidic device using one or more slidable blocks having at least one fixed-length sample metering channel. In another aspect of the present invention, fixed volumes of samples are metered into the reaction channel using one or more slidable blocks having at least one fixed-length sample metering channel. In another aspect of the present invention, a sample injection scheme based on injection time is implemented using relatively sliding blocks of separation channels and sample channels. In a further aspect of the present invention, separation channels are configured in relation to the slidable block in a manner that enables separations to be conducted continuously for high-throughput assays.

Abstract: Disclosed herein are apparatuses and devices, and methods for using and making the same, for use in performing desired activities in an automated, microscale format. Microparticles are ushered about within a microscale apparatus, to selectively move between various stations in a selected order and manner. Some embodiments include reaction, micro-weighing, micro-analysis, reagent acquisition and deposition, and incubation stations. Microparticles can individually move, or move as trains. Samples, including particulate and solid tissue samples may be manipulated and analyzed within the device. Some embodiments may engage in micro-fabrication activities or micro-deconstruction activities. Systems for controlling such apparatuses are included as well as methods of operation.

Abstract: A plating method and apparatus using contactless electrode is described. In one embodiment an inductive element is placed proximally to a substrate and a moving electromagnetic field generates an emf in the substrate to plate the surface. In another embodiment, a conductive plate is used, so that the conductive plate and the wafer, separated by a dielectric material, operate as two plates of a capacitor when voltage is applied to the conductive plate. The resulting electrostatic field impresses a charge potential on the substrate to plate the surface of the substrate.

Abstract: The use of impedance measurements to detect the presence of pathogens attached to antibody-coated beads. In a fluidic device antibodies are immobilized on a surface of a patterned interdigitated electrode. Pathogens in a sample fluid streaming past the electrode attach to the immobilized antibodies, which produces a change in impedance between two adjacent electrodes, which impedance change is measured and used to detect the presence of a pathogen. To amplify the signal, beads coated with antibodies are introduced and the beads would stick to the pathogen causing a greater change in impedance between the two adjacent electrodes.

Abstract: Disclosed herein is a microchip provided with a specimen flow pass, a reagent flow pass, a confluence flow pass all of which are fine flow passes. The specimen flow pass allows specimen to flow toward one end thereof. The reagent flow pass is connected to that end of the specimen flow pass and allows at least one reagent to flow for reaction with the specimen. The confluence flow pass extends from that end of the specimen flow pass and allows the confluent specimen and reagent to flow. A sensing portion is assigned near or at the confluence flow pass, and the reaction of the specimen and the reagent is capable of being detected or observed there. Further to this, the microchip comprises a force applying means for reciprocally moving the specimen and the reagent at the sensing portion.