Abstract: A formulation for use in the controlled generation of phosphine comprises a mixture of a particulate phosphide and a water-immiscible compound. The water-immiscible compound is paraffin oil, petroleum jelly, a mixture of these materials or a wax having a melting point in the range 35° C. to 65° C. The phosphide comprises from 65 to 85 per cent (by weight) of the formulation. Such a formulation can be added progressively to water in a reaction chamber. Alternatively, the formulation can be packaged in a water-impermeable container from which a region can be removed to expose the formulation to water vapor in a gas flowing past the container. The water or the water vapor reacts with the phosphide particles as they become exposed to form phosphine. The phosphine, mixed with a carrier (usually air), may be fed into a duct connected to a grain silo, for fumigation of grain stored in the silo.

Abstract: Methods and compositions useful for inducing a cytotoxic T lymphocyte response (CTL) in a human or domesticated or agriculturally important animal. The method includes the steps of providing the antigen to which the CTL response is desired and providing an antigen formulation which comprises, consists, or consists essentially of two or more of a stabilizing detergent, a micelle-forming agent, and an oil. This antigen formulation is preferably lacking in an immunostimulating peptide component, or has sufficiently low levels of such a component that the desired CTL response is not diminished. This formulation is provided as a stable oil-in-water emulsion.

Abstract: An adhesive cosmetic strip is provided which includes a flexible water-insoluble substrate, an adhesive composition deposited onto the substrate, a liquid crystal thermochromic substance, and an agent interactive with water to ensure a temperature rise of at least 2° C. in the strip. The thermochromic substance may be impregnated into the substrate or dispersed within the adhesive composition. When applied to the skin, the strip is warmed by a reaction between water and an exothermic or endothermic agent held within the strip. Moisture within the skin or externally applied water penetrates the strip and will react with the agent to cause an increase in temperature. Subsequently this increase in temperature will induce a color change in the thermochromic substance.

Abstract: A fragrance-containing coating composition for paper substrates consists essentially of a polyvinyl chloride (PVC) plastisol and one or more fragrances, for example, an insect repellant. The PVC plastisol contains an adhesion promoter when the paper substrate is a calendered and/or coated paper substrate. The coating is fused at about 320° F. for 15-30 seconds. The coated paper is stored in barrier bags.

Abstract: Bioaffecting sachets, or powders, containing coated liquiflash microspheres and partially recrystallized shearform floss particles are disclosed. The sachets give organoleptically acceptable properties, including a pleasing mouthfeel, when orally ingested.

Abstract: A pharmaceutical lozenge for the modified release of active compounds in the gastrointestinal tract is described, with active-compound-containing particles which have a first coating controlling the release and a further, outer coating with saliva-resistant properties. The first coating, which controls the release of active compound, can have release-delaying or enteric properties.

Abstract: Improved cation exchange zeolite crystalline and zeolite-like plant bed structures are disclosed, preferably saturated with water-based extracts of particular plant/herb materials exhibiting plant growth acceleration properties and synergistically providing also nutrient, and sometimes anti-microbial and insect and fungus repellent properties, as well, and with the adaptability to present the structures in solid, gel and liquid form.

Abstract: A mixed liposome pharmaceutical composition with multilamellar vesicles is provided. The vesicles are comprised of a pharmaceutical agent, membrane-mimetic amphiphiles and various phospholipids. A method of making the composition using high speed mixing of the amphiphiles and phospholipids is also provided.

Abstract: Biocompatible metallic medical devices having silanized surfaces coupled to nucleophile residues that release sustained, therapeutic amounts of nitric oxide to specific sites within a mammalian body are provided. Additionally, the biocompatible metallic medical devices can also be provided with anti-thrombogenic, lubricious coatings that release sustained, therapeutic amounts of nitric oxide. Moreover, the silanized metallic devices are surprisingly durable when exposed to harsh chemical methods often needed to bind nitric oxide-releasing functional groups to nucleophile residues. Furthermore, methods are provided for producing stable, silanized, sustained nitric oxide-releasing metallic medical devices.

Abstract: A pharmaceutical composition comprising a lipid complex or a liposome of a phospholipid and a water-insoluble platinum dicarboxylate and method for the preparation of such compositions are described.

Abstract: Compositions of the invention include composites comprising a biomaterial having compounds thereon with enhanced cell binding with respect to collagen. These composites are useful for soft and hard tissue repair or reconstruction and for in vitro uses. Suitable compounds with enhanced cell binding include synthetic peptides that mimic the conformation necessary for recognition and docking of collagen binding species (such as cell surface receptors for collagen and fibronectin) and have the amino acid residues -Ile-Ala-folded in a &bgr;-bend.

Abstract: The invention provides a sunscreen formulation including conventional UVB sunscreening agents and zinc oxide having an average particle size in the order of 150 to 800 nm. Preferably the zinc oxide used is pigment grade. Most preferably, zinc oxide prepared by the French process is used, although that produced by the American process is also suitable. The average particle size of the zinc oxide is most preferably in the order of 200-400 nm. Throughout this specification, the term “pigment grade” is used to define zinc oxide that has been produced by the French or American process. A further embodiment of the invention is a method of reducing or preventing the harmful effects of solar radiation on skin by applying inventive sunscreen formulation. A further embodiment of the invention relates to a sunscreen composition having a sun protection factor greater than 30 including zinc oxide having an average particle size of 150 to 800 nm.

Abstract: A sensate composition is provided for imparting a long lasting cooling effect on skin. The composition is a combination of menthyl lactate, isopulegol and menthoxypropanediol, the latter providing a cooling enhancing effect. Cosmetic compositions can be prepared incorporating the sensate composition.

Abstract: Unit-of-use reagent compositions and methods for preparing such reagent compositions are disclosed. The reagent composition comprises one or more reagents which are necessary for a specific binding assay and which are incorporated in a porous material which is encapsulated in a carrier matrix. The unit-of-use reagent composition can be lyophilized to avoid the need for cold storage of the reagent composition.

Abstract: The present invention provides a pharmaceutical composition, kit, and method of forcing the reverse transport of cholesterol from peripheral tissues to the liver in vivo while controlling plasma LDL concentrations. The method includes the step of administering a therapeutically effective amount of a multiplicity of large liposomes comprised of phospholipids substantially free of sterol for a treatment period. The method optionally includes the step of periodically assaying plasma LDL concentrations with an assay during the treatment period to assess plasma atherogenic lipoprotein concentrations and obtain an atherogenic lipoprotein profile, and adjusting the administration in response to said profile. The large liposomes are dimensioned larger than fenestrations of an endothelial layer lining hepatic sinusoids in the liver so that the liposomes are too large to readily penetrate the fenestrations.

Abstract: Cosmetic compoaition for topical application to the skin comprising a hydroxyalkyl cyclodextrin, salicylic acid or salicylic acid derivative and water. The compositions herein provide improved anti-acne/anti-inflammatory activity together with reduced skin irritation.

Abstract: A composition useful in a delivery system for water-insoluble ingredient(s) containing at least one organic phospholipid capable of forming bilayers in aqueous solution; at least one amphoteric surfactant present in an amount by weight equal to or greater than the amount of the phospholipid; at least one nonionic surfactant present in an amount by weight equal to or greater than the amount of the phospholipid; and at least one cationic polymer, wherein the cationic polymer functions to control the amount of water-insoluble ingredient(s) deposited on keratinous substances. A method for treating keratinous substances with the compositions and delivery systems is also disclosed. In addition, the amount of water-insoluble ingredient(s) to be deposited can be controlled by varying the amount of the phospholipid, the nonionic surfactant, or both.

Abstract: The invention relates to a cosmetic composition comprising: (i) greater than 2% of a panthenol oil regulating agent; and (ii) from 0.1 % to 10% of a particulate, oil-absorbing polymer, and (iii) from 20% to 97.9% of a cosmetically acceptable carrier. The compositions, which preferably take the form of oil-in-water emulsions, provide both immediate and long-term control of oily and/or shiny skin.

Abstract: Transderml therapeutic systems are disclosed for the controlled administration of second and third generation gestagenes, and possibly of oestrogens, at least partially dissolved in a matrix. The disclosed systems are characterised in that their matrix contains a copolymer of one or several esters or amides which contain vinyl groups and have the general formula (I), as well as an N-vinyl lactam of general formula (II). In the general formula (I), X symbolises a -COO- group, a -CONH- group or an -OCO- group; R1 stands for a hydrogen atom or an alkyl group with maximum 4 carbon atoms; and R2 stands for a hydrogen atom or an alkyl group with maximum 12 carbon atoms. In the general formula (II), n is a digit from 3 to 5.

Abstract: A hair treating and skin care preparation for use alone or as a component in other preparations, for use in hair dyeing, bleaching, hair conditioning or skin treatments comprises a mixture of hydrogen peroxide, a silicon component selected from the group consisting of silica gel, silicic acid anhydride and mixtures thereof, and a relatively small amount of Aloe vera gel. Prior to use, at least 1.5 g of leaf material from an Aloe vera plant per liter of the hydrogen peroxide, silicon component and aloe vera mixture are placed in the mixture for at least 12 hours in order to dissolve active components from the leaf material and then the undissolved remnants are removed. The preparation can be used for treating skin conditions such as a rash or eczema. A similar preparation can also be combined with water and one or more herbs to provide a health providing remedy that is applied to the skin.

Abstract: A vinylic copolymer comprising repeat units of A, B and C These copolymers have an acid content of 0.015 to 0.50 milliequivalents per gram of copolymer. Compositions that provide these copolymers in easily handled forms, and cosmetic compositions comprising the copolymer are also provided.

Abstract: Compositions for treating hair prepared using fluorinated acids to neutralize polymers with basic groups are described, which contain a complex formed from at least one fluorinated acid and at least one polymer with basic groups or a complex of a salt of a fluorinated acid and a polymer with protonated or quaternized amine groups, and which also contain at least one film-forming, hair-fixing polymer. These compositions deposit a reduced amount of residue on the hair without reducing the hair-fixing performance.

Abstract: The invention relates to ultrasonic contrast agents consisting of microparticles which consist of amyloses and synthetic biodegradable polymers and a gas and/or a fluid with a boiling point below 60° C., process for the preparation thereof and their use as diagnostic and therapeutic agents.

Abstract: The claimed invention pertains to methods for treating a patient who is at risk for a vascular (e.g., cardiovascular, cerebrovascular) event comprising administering to the patient an effective amount of a lipid-modifying drug. The claimed methods are particularly effective in patients having a lipid profile comprising a low Low Density Lipoprotein and a low High Density Lipoprotein.

Abstract: There is disclosed an aerosol comprising droplets of an aqueous dispersion of nanoparticles, said nanoparticles comprising insoluble therapeutic or diagnostic agent particles having a surface modifier on the surface thereof. There is also disclosed a method for making the aerosol and methods for treatment and diagnosis using the aerosol.

Abstract: The present invention relates to hair conditioning shampoo compositions which includes:

Abstract: The present invention relates to pharmaceutical preparations in the form of aqueous solutions for the production of propellant-free aerosols.

Abstract: The claimed invention pertains to methods for treating a patient who is at risk for a vascular (e.g., cardiovascular, cerebrovascular) event comprising administering to the patient an effective amount of a lipid-modifying drug. The claimed methods are particularly effective in patients having a lipid profile comprising a low Low Density Lipoprotein and a low High Density Lipoprotein.

Abstract: The invention provides a hair treatment composition such as a shampoo or conditioner suitable for topical application to hair for the repair and prevention of damage, comprising (i) cholesterol, and (ii) a hair benefit agent which is a mixture of a basic amino acid and a fatty acid. Preferably the cholesterol and hair benefit agent are compounded into a dispersion of multilamellar vesicles, stabilized with nonionic surfactant.

Abstract: A composition and method for causing a positive psychoactive effect in which phenylalanine, vitamin B-6, vitamin C, copper, folic acid, taurine, vitamin B-5 (or pro-vitamin B-5), choline, fruit sugar, caffeine, and optionally green tea are combined in a carbonated mixture. The mixture is orally administered in beverage form to support the production of and to stimulate release of neurotransmitters and neuromodulators in the brain and to enhance and modulate their effects to produce a positive psychoactive effect.

Abstract: The present invention relates to the use in cosmetics of rigid gels containing at least 20% by weight of one or more water-soluble or hydrophilic gelling agent(s) which may be obtained from the said water-soluble or hydrophilic gelling agent in the presence of water by mixing, blending, compression and extrusion in a twin-screw extruder. These gels constitute novel pharmaceutical forms for cosmetic or dermatological use. These gels are generally in the form of sticks, pencils or cakes. They may be aqueous with a matrix consisting of an aqueous gelled network. They may be in anhydrous form with a matrix consisting of a dehydrated gelled network. They may constitute many products in solid form applied to making up, to care of and/or to treatment of the skin, the scalp, the hair or the mucous membranes, or alternatively applied to the hygiene of the body, the skin, the scalp, the hair or the mucous membranes.

Abstract: A cream formulation for topical application to an external portion of a human body. A one ounce preparation of such cream formulation includes active ingredients consisting essentially of a predetermined weight of an aloe vera gel compound present in the topical formulation generally in a weight range of between about 3 grams and about 10 grams. A predetermined weight of a preselected zinc compound present in the topical formulation generally in a weight range of between about 0.4 grams and about 1.5 grams. A predetermined weight, expressed as IU, of vitamin E present in the topical formulation generally in a weight range of between about 200 IU and about 9000 IU. The balance of such one ounce preparation of the topical formulation being made up of water, organic solvents, carriers and emollients.

Abstract: Tissue paper webs useful in the manufacture of soft, tissue products such as wipes and facial tissues, and processes for making the webs are described. The tissue paper webs include papermaking fibers, an antimigration material and an emollient lotion. Preferred antimigration materials include quaternary ammonium compounds. Preferred emollient lotions include a hydrocarbon emollient. The preferred process for making the preferred invention includes providing the antimigration material to the papermaking furnish and depositing the emollient lotion onto at least one surface of the dried tissue web that includes an antimigration material.

Abstract: Antiperspirant emulsions which exhibit excellent phase stability even in the presence of an effective concentration of antiperspirant salts in solution and which are thickened are obtainable by dispersing a hydratable polymer and particularly an amphoteric or cationic modified starch in an aqueous emulsion forming a viscous emulsion, often at an elevated temperature, subjecting the emulsion to high shear, thereby reducing the droplet size of the dispersed oil phase, bringing the emulsion to below 40° C. and introducing the antiperspirant, preferably in aqueous solution. The viscous emulsion subjected to high shear mixing desirably has a Sheer Stress of 10 to 500 Pa. The resultant emulsions show good phase stability even when they contain aluminium/ zirconium antiperspirant salts that promote instability and even at elevated storage temperatures such as at 50° C.

Abstract: A colored, sunless tanning emulsion is disclosed which employs a water-soluble dye or a blend of water-soluble dyes whose color substantially disappears when the sunless tanning emulsion dries after it is spread on the skin and/or is rubbed out.

Abstract: A carrier patch for delivering agents locally to the skin or systemically via the skin. The patch comprises a pad having a lower surface area to which an adhesive is adhered, and a primary agent applied to discrete regions of the patch in a manner to minimize the deleterious effects of the adhesive on the primary agent. The invention further comprises a method for the discrete application of the agent to the patch, and a method of using the patch for the delivery of the agent to the skin.

Abstract: A cosmetic, pharmaceutical, or dermatological patch includes a composition including a hydrophilic gelling system in an aqueous phase. The hydrophilic gelling system includes at least one gellan gum and at least one other hydrocolloid.

Abstract: Although poly ICLC possess a broad spectrum of antimicrobial and anticancer activities, it therapeutic potential has yet to be fulfilled due to its toxic side effect. This problem can be overcome by encapsulating poly ICLC within liposomes which provides a drug delivery system with slow sustained release characteristic and which has the ability to target the drug to sites of infection and tumor without causing systemic burden to normal tissues, thereby enhancing the immunological and biological activities of poly ICLC.

Abstract: Compositions and methods for transport or release of therapeutic and diagnostic agents or metabolites or other analytes from cells, compartments within cells, or through cell layers or barriers are described. The compositions include a membrane barrier transport enhancing agent and are usually administered in combination with an enhancer and/or exposure to stimuli to effect disruption or altered permeability, transport or release. In a preferred embodiment, the compositions include compounds which disrupt endosomal membranes in response to the low pH in the endosomes but which are relatively inactive toward cell membranes, coupled directly or indirectly to a therapeutic or diagnostic agent. Other disruptive agents can also be used, responsive to stimuli and/or enhancers other than pH, such as light, electrical stimuli, electromagnetic stimuli, ultrasound, temperature, or combinations thereof.

Abstract: A non-toxic oil-in-water or bicontinous microemulsion used as a pharmaceutically acceptable vehicle for administration of one or more active compounds having a low solubility in water as well as a process for the preparation and the use thereof.

Abstract: Lipids are used as aids in the production of solid drug forms by melt extrusion.

Abstract: The present invention is directed to a semi-solid formulation comprising a lipid-regulating agent. Said formulation is prepared by solubilizing said lipid-regulating agent in one or more liquid components to form a clear liquid solution, then solidifying said solution by adding one or more solid or semi-solid components to said solution to form a semi-solid formulation. Said formulation can melt or dissolve upon mixing with a bulk aqueous medium. The resulting formulation results in an increase in drug solubility and oral bioavailability, and an improved dissolution rate.

Abstract: The invention provides an external-use composition imparting no sticky sensation in use, particularly an external-use composition for a cosmetic composition exhibiting excellent retention during use, by finding a gelling agent for an oily ingredient, particularly for silicone oil. The external-use composition contains a spherical powder (mean particle size: 0.1-200 &mgr;m) of organopolysiloxane elastomer having a JIS A hardness of 1.0-30.

Abstract: The present invention relates to sustained-release formulations using alginate delayed gels and methods thereof.

Abstract: There is provided improved compositions for the delivery of pharmacological agents to the respiratory tract of a mammal to provide improved peripheral deposition and systemic uptake wherein a therapeutic agent is incorporated into a polysaccharide microparticle through a process of spray drying.

Abstract: A pharmaceutically acceptable solution with a medicament suitable for filling a soft gelatin capsule is made from a solvent. The solvent contains a polymer, such as polyethylene glycol, and an acid salt of a compound having 3 or more carbon atoms, and a salt such as sodium propionate. The solvent may optionally contain a cosolvent, such as dimethyl isosorbide. The medicament may preferably comprise an analgesic such as aspirin or naproxen.

Abstract: The present invention is directed to a process for preparing a formulation comprising a lipid-regulating agent dissolved in a supercritical fluid, spraying the solution through a nozzle to form small particles of the lipid-regulating agent, forming a suspension of the particles of said lipid-regulating agent in a liquid, and collecting the particles.

Abstract: Disclosed are solid cosmetic stick compositions having a preferred product hardness of at least about 600 gram.force, and which comprises from about 0.01% to about 60% by weight of a cosmetic active; from about 10% to about 95% by weight of a liquid carrier; from about 1% to about 60% by weight of a solid polymorphic triglyceride gellant that within the composition is substantially free of long range crystalline order. By selecting the crystalline phase of the triglyceride gellant in the finished product, these cosmetic sticks provide improved product hardness at lower triglyceride gellant concentrations.

Abstract: The present invention provides a stable gel formulation for topical treatment of skin conditions in humans. The stable gel formulation includes an active agent, having activity for treatment of acne and psoriasis, which is insoluble in water and a plurality of nonaqueous vehicles for both solubilizing said active agent and forming a gel therewith enabling topical application of the gel to a skin condition. The plurality of vehicles are each present in amounts, and in combination, to control release of the active agent from-the gel to the skin condition.

Abstract: The present invention relates to compositions comprising non-toxic and safe for human contact and ingestion volatile or non-volatile silicone-aliphatic hydrocarbon hybrid fluids and a non-volatile silicone-aliphatic hydrocarbon hybrid wax which have the physical consistency of a gel which are of use in a wide variety of personal care applications and when applied to the human skin components within these compositions adsorb quickly into the upper layers of the status corneum, while other components form non-tacky occlusive films on the outer surface of the stratum corneum.