Abstract: In one embodiment, an ambulatory insulin infusion system may include an administration module for insulin administration, a data collection module for collecting data relevant for the bolus amount, and a delay module. The administration module may administer insulin continuously according to a basal profile and a bolus on demand. The bolus has a bolus amount. The data collection module may be operatively coupled to the administration module. The delay module may trigger administration of the bolus a therapeutically significant delay interval after the data is collected.

Abstract: A patch-sized fluid delivery device may include a reusable portion and a disposable portion. The disposable portion may include components that come into contact with the fluid, while the reusable portion may include only components that do not come into contact with the fluid. Redundant systems, such as redundant controllers, power sources, motor actuators, and alarms, may be provided. Alternatively or additionally, certain components can be multi-functional, such a microphones and loudspeakers that may be used for both acoustic volume sensing and for other functions and a coil that may be used as both an inductive coupler for a battery recharger and an antenna for a wireless transceiver. Various types of network interfaces may be provided in order to allow for remote control and monitoring of the device.

Abstract: A cylinder-piston unit, with at least one cylinder accommodating an injection solution and having an outlet opening, and with at least one piston. The cylinder, or a component mounted upstream of the cylinder, has an end face from which, during correct emptying of the cylinder-piston unit, a short cannula protrudes, which has an outlet opening at its free end. The outlet opening has a surface with a border which has a point near the bottom or an edge near the bottom. The point near the bottom or the edge near the bottom lies 0.15-0.3 mm away from the end face or the front-most point or edge thereof. A cylinder-piston unit is developed which is intended for a disposable injector and which is suitable for virtually painless penetration of the human skin, among other reasons for the administration of highly viscous injection solutions.

Abstract: A liquid injector registers the data of a variable pattern in which an injection rate of a contrast medium varies with time. The injection rate of the contrast medium varies with time according to the variable pattern for maintaining a state in which the image contrast achieved by the contrast medium approximates an optimum level.

Abstract: Described is a cartridge comprising a case adapted to detachably engage an autoinjector, an ampoule containing a medicament, and a needle magazine containing a plurality of double-tipped needle assemblies. An autoinjector comprises the cartridge, a housing adapted to detachably engage the cartridge and a user interface adapted to provide visual, audible or tactile feedback.

Abstract: A medical device is provided comprising a transcutaneous device unit and a reservoir unit. The transcutaneous device unit comprises a transcutaneous device for transporting a fluid through a skin portion of a subject, and a mounting surface adapted for application to the skin of the subject. The reservoir unit comprises a reservoir adapted to contain a fluid drug, the reservoir comprising an outlet means allowing the transcutaneous device to be arranged in fluid communication with an interior of the reservoir, and an expelling assembly for expelling a fluid drug out of the reservoir and through the skin of the subject via the transcutaneous device. The transcutaneous device unit and the reservoir unit further comprise coupling means allowing the reservoir unit to be secured to the transcutaneous device unit in the situation of use. By this arrangement a two-unit system is provided which can be used in a convenient and cost-effective manner.

Abstract: An implantable fluidic valve actuated by osmotic pressure gradient and methods of operating it are provided. The valve includes: an input fluid channel; an output fluid channel in fluid communication with the input fluid channel at an aperture; and a semi-permeable membrane forming a portion of a sealed chamber. The semi-permeable membrane may have an outer surface forming a wall of the input fluid channel, and an inner surface forming a wall of the sealed chamber, the membrane being configured to allow diffusion of a solvent into and out of the sealed chamber; and a first electrode and a second electrode disposed within the sealed chamber configured to receive a voltage. A pump including the above elements and a check valve is provided. An ocular implant including an inlet tube sized to receive aqueous humor and an intra-ocular pressure control system having a fluidic valve as above is also provided.

Abstract: A method of seating a fluid reservoir in a housing of a fluid infusion device is presented here. The method is performed prior to establishing an outgoing fluid flow path from the fluid reservoir. The method begins by detecting insertion of the fluid reservoir into the housing of the fluid infusion device. In response to detecting the insertion, the method determines whether the fluid reservoir is in need of depressurization. When the fluid reservoir is in need of depressurization, the drive motor assembly of the fluid infusion device is rewound to depressurize the fluid reservoir. After depressurizing the fluid reservoir, an equalization state for the fluid reservoir is achieved. After achieving the equilibrium state, the drive motor assembly is advanced to obtain an initial seated state for the fluid reservoir.

Abstract: Described is a drive mechanism for a drug infusion pump. In one embodiment, an in-line drive mechanism is provided that includes a motor operatively coupled to a lead screw, which is configured to engage a piston. The piston includes a cavity to receive the motor and the lead screw such that the lead screw and at least a portion of the motor are substantially contained within the piston cavity when the piston is in a retracted position. In one embodiment, the motor rotates a drive shaft is configured to turn a mechanism comprising a piston, a lead screw, and a housing that cooperate to extend telescopically to drive a plunger into a medicament cartridge, thereby expelling fluid.

Abstract: Processor-implemented methods of controlling an insulin infusion device for a user are provided here. A first method obtains a current insulin on board (IOB) value that estimates active insulin in the user, and compensates a calculated insulin infusion rate in response to the obtained IOB value. A second method supervises the operation of a glucose sensor by obtaining and processing insulin-delivered data and glucose sensor data for the user. An alert is generated if the second method determines that a current glucose sensor value has deviated from a predicted sensor glucose value by at least a threshold amount.

Abstract: An insertion mechanism for a drug pump includes an insertion mechanism housing; a manifold guide; an insertion biasing members initially held in an energized state; a retraction biasing member and a hub connected to a proximal end of a needle, wherein the retraction biasing member is held initially in an energized state between the hub and the manifold guide; and a manifold having a septum and a cannula, wherein the annular space between the septum and the cannula defines a manifold header. The needle and cannula are inserted into the body of a user by the insertion biasing member(s), after which only the needle is retracted. Retraction of the needle may open a fluid pathway from the manifold header to the body through the cannula. A drug delivery pump includes an activation mechanism, a drive mechanism, a fluid pathway connection, and the insertion mechanism. Assembly and operation methods are provided.

Abstract: A medicament delivery device is presented for the administration of one or more drug agents, wherein the device comprises a retainer for holding a medicament cartridge. The retainer is moveable between an open and closed position. A position sensor for generating a position output is indicative of whether the retainer is in the open or closed position. Further, a cartridge sensor generates a cartridge output indicative of whether the retainer is holding a medicament cartridge. A controller controls a predetermined operation of the device in dependence on the output of the position sensor and on the output of the cartridge sensor.

Abstract: A System manages IV pumps so that clinicians automatically receive alerts, decisions, and actions required to maintain a patient IV medication therapy according to a prescribed treatment protocol. An infusion pump monitoring system, includes an acquisition processor for acquiring fluid infusion parameters comprising a patient identifier, infusion fluid identifier and a rate of fluid infusion, for administration of an infusion fluid to a patient at a point of care using an infusion pump. The system also includes a repository of patient medical record information. A fluid infusion monitor uses acquired fluid infusion parameters for automatically searching a patient medical record in the repository for information concerning rate of fluid infusion of a particular infusion fluid and determining if a rate of a previously administered dose of the particular infusion fluid was lower than a rate indicated in the fluid infusion parameters.

Abstract: Methods of providing sympathetic nerve blocks comprise inserting a portion of a catheter into a subject. A distal end of the catheter is positioned on a lateral side of at least one vertebra of a vertebral column of the subject proximate to a portion of a sympathetic nervous system of the subject. A medication is supplied through the catheter to effect a sympathetic nerve block in the subject. Methods of alleviating pain in lower extremities of subjects comprise inserting a portion of a catheter into a subject and supplying a medication through the catheter. Catheters and catheter assemblies may be used in administering such sympathetic nerve blocks. Catheters and catheter assemblies may be used in administering medication to one or more of a peripheral nervous system of a subject and a spinal cord of a subject.

Abstract: An apparatus for controlled delivery of a flow of breathing gas to the respiratory tracts of a user includes a blower unit adapted to provide a gas flow, a nasal cannula with first and second outlets, and first and second gas paths connecting the blower unit to the first and second outlets, respectively. The Characteristics of the gas flow through each outlet can be controlled, sensed and/or adjusted independently.

Abstract: Systems and methods for processing sensor data and end of life detection are provided. In some embodiments, a method for determining the end of life of a continuous analyte sensor includes evaluating a plurality of risk factors using an end of life function to determine an end of life status of the sensor and providing an output related to the end of life status of the sensor. The plurality of risk factors may be selected from the list including the number of days the sensor has been in use, whether there has been a decrease in signal sensitivity, whether there is a predetermined noise pattern, whether there is a predetermined oxygen concentration pattern, and error between reference BG values and EGV sensor values.

Abstract: A dosing method using a device for transferring and dosing biomedical fluids between hospital containers includes a syringe body containing a biomedical fluid and a piston sealed fitted therein, the syringe body including a first extremity having joining elements to a first container and to a second container, and a second extremity opposite the first extremity, the method including gripping a handle having a coupling seat for fastening to the second extremity; placing first temporary fastening elements between the coupling seat and second extremity; placing second temporary fastening elements between the piston and thrust rod; operating a thrust rod of a motorized element mounted in the handle for pushing the piston; and dosing using control elements mounted on the handle, associated with the motorized element to dose volumetric quantities of biomedical fluid from the first container and dispensing to the second container.

Abstract: An apparatus comprising a controller. The controller includes an input/output (I/O) module and a rule module. The I/O module is configured to present a question for a patient when communicatively coupled to a user interface and receive patient information in response to the question via the user interface. The rule module is configured to apply a rule to the patient information and generate a suggested insulin pump setting from application of the rule. Other devices, systems, and methods are disclosed.

Abstract: A medicament delivery device includes a housing; a carrier for a medicament container, the carrier being slidable in the housing; a trigger unit; a cover unit coaxial and slidable in the housing; a release mechanism configured to be actuated partly by the trigger unit and partly by movement of the cover unit; a preloaded drive unit releasably connected to the carrier and controlled by the release mechanism for advancing the carrier to a predetermined proximal position in relation to the housing, the preloaded drive unit having a plunger rod and a helical drive spring disposed within the plunger rod, with at least one end of the helical drive spring configured to interact with an interior of the plunger rod; and a braking mechanism between the preloaded drive unit and the release mechanism configured to control a speed of the preloaded drive unit when advancing the slidable stopper within the container.

Abstract: The present invention relates to a medical device for administering a medicinal product to a patient comprising at least one component (2, 8, 10, 12, 14, 15, 16, 17, 18, 20, 22, 24, 26, 28) comprising a material having an additive embedded therein, wherein the additive is adapted to provide a visually perceptible signal when exposed to electromagnetic radiation. The invention is particularly intended for drug delivery devices, such as e.g. of pen-type injectors. With the visually perceptible signal embedded in the at least one component, visually controlled assembly of such devices can be improved. Additionally the invention provides an effective means antagonize counterfeiting of drugs and of medical devices.

Abstract: A portable pump for infusing liquid substances into a body is provided. The pump has a casing and electromechanical members for converting rotary motion of a motor shaft into linear sliding motion of a pusher for causing movement of a plunger slideable within an interchangeable reservoir in which the substance to be infused is contained in a housing. The housing communicates through an opening formed in a casing wall through which the reservoir can be inserted into and removed from the housing and from which an appendix of the reservoir protrudes for the exit of the substance. The housing has a distal portion with mechanical means for reversible engagement of the reservoir end opposite to the appendix and a proximal portion provided with an annular sealing gasket which surrounds the reservoir and forms a seal between the reservoir and casing wall.

Abstract: A medication injection pen (50) includes a housing (1) and a dose set knob (2) rotatably connected to the housing (1) for setting a dose. An indicator member (200) is movable between an visible position indicating a zero position of the dose set knob (2) and a non-visible position indicating a non-zero position of the dose set knob (2). The indicator member is visible to a user in the visible position and not visible in the non-visible position. The dose set knob is in the zero position when a set dose has been completely administered. Accordingly, a visible indication is provided to a user when a set dose has been completely administered.

Abstract: An implantable electroacupuncture device (IEAD) treats Parkinson's disease or Essential Tremor through application of stimulation pulses applied at at least one of acupoints GB34 and GV20. The IEAD includes an hermetically-sealed implantable electroacupuncture (EA) device having at least two electrodes located outside of its housing. The housing contains a primary power source, pulse generation circuitry, and a sensor that wirelessly senses externally-generated operating commands. The pulse generation circuitry generates stimulation pulses as controlled, at least in part, by the operating commands sensed through the sensor. The stimulation pulses are applied to the specified acupoint or nerve through the electrodes in accordance with a specified stimulation regimen. Such stimulation regimen requires that the stimulation session be applied at a very low duty cycle not greater than 0.05.

Abstract: Disclosed is an ambulatory therapeutic fluid delivery device. The device includes at least one housing connectable to a cannula, the at least one housing retaining a reservoir to hold the therapeutic fluid. The device also includes a mechanically powered pumping mechanism to cause delivery of at least some of the fluid from the reservoir, and a power-transfer mechanism to transfer manually-delivered power provided by a user to mechanically actuate the pumping mechanism.

Abstract: Various endograft assemblies and methods for using the same. In at least one embodiment of an endograft assembly of the present disclosure, the endograft assembly comprises an endograft and a tube defining one or more tube openings coupled to said endograft. In another embodiment of an endograft assembly of the present disclosure, the endograft assembly comprises an endograft, a sponge sheath coupled to the endograft, and a reservoir bag coupled to the sponge sheath, said reservoir bag capable of receiving fluid from the sponge sheath.

Abstract: An infusion pump device comprising a primary liquid medicament reservoir, a pump with a secondary reservoir to retrieve medicament from the primary reservoir and to subsequently dose the medicament from the secondary reservoir in adjustable volumes (Vdose,i) to a downstream conduit and a control unit to control the operation of the infusion pump device is presented. For metering the volumes (Vdose,i), the control unit causes the infusion pump device to: (a) determine a maximum refill level (VC,max) for the secondary reservoir, based on external parameters, wherein the maximum refill level does not exceed the maximum capacity of the secondary reservoir; (b) fill the secondary reservoir with medicament from the primary reservoir to the maximum refill level (VC,max); (c) meter and convey the medicament volumes to the downstream conduit; (d) if the secondary reservoir becomes empty, refill the secondary reservoir as in step (b) and continue with step (c).

Abstract: Methods, system and devices for monitoring a plurality of parameters associated with a closed loop control operation including continuously monitoring a physiological condition and automatic administration of a medication, detecting a signal level associated with the monitored physiological condition deviating from a predetermined threshold level, retrieving the medication level administered associated with a time period of the detected signal level, applying the retrieved medication level to the detected signal based on a predefined predictive model to generate a predictive signal, and comparing the detected signal to the predictive signal to determine whether a condition associated with the detected signal level is present are provided.

Abstract: A hand-held remote for a medical fluid injector includes a syringe and a conduit which may be coupled to a pressure transducer on a control circuit of the injector. Movement of a plunger within a syringe body on the syringe creates a pressure which is sensed by the pressure transducer and the control circuit responds to the sensed pressure by causing fluid to be ejected from, or drawn into, a syringe mounted to the injector. The pressure developed by the remote provides tactile feedback to an operator for improved control over injections.

Abstract: An insulin injection pen and blood glucose monitoring device is integrated into a single unit that fits in a user's clothing pocket or handbag. The device includes a blood glucose monitoring system for detecting the user's blood glucose level, an insulin injection mechanism, and a microprocessor that calculates an insulin dosage appropriate to the detected blood glucose level of a particular user and sets the insulin injection mechanism to administer the calculated insulin dosage. The device automatically informs a remote emergency service provider if the microprocessor determines that the detected blood glucose level presents a potential danger to the user. The microprocessor also calculates treatment regimens based on the detected blood glucose level and displays the treatment regimens on an LCD display. The device can include a GPS receiver that detects the location of the device, which is transmitted by the device to the remote emergency service.

Abstract: A fluid handling cassette, such as that useable with an automated peritoneal dialysis (APD) cycler device or other infusion apparatus, may include a generally planar body having at least one pump chamber formed as a depression in a first side of the body and a plurality of flowpaths for a fluid that includes a channel. A patient line port may be arranged for connection to a patient line and be in fluid communication with the at least one pump chamber via at least a first one of said flowpaths, and an optional membrane may be attached to the first side of the body over the at least one pump chamber. In one embodiment, the membrane may have a pump chamber portion with an unstressed shape that generally conforms to the depression of the at least one pump chamber in the body and is arranged to be movable for movement of the fluid in a useable space of the at least one pump chamber.

Abstract: Systems and methods for processing sensor data are provided. In some embodiments, systems and methods are provided for calibration of a continuous analyte sensor. In some embodiments, systems and methods are provided for classification of a level of noise on a sensor signal. In some embodiments, systems and methods are provided for determining a rate of change for analyte concentration based on a continuous sensor signal. In some embodiments, systems and methods for alerting or alarming a patient based on prediction of glucose concentration are provided.

Abstract: Ambulatory infusion pumps, pump assemblies, cartridges, baseplates, cannulas, insertion tools, and related components as well as combinations thereof and related methods.

Abstract: Embodiments of dermalogical cell treatment are described generally herein. Other embodiments may be described and claimed.

Abstract: Some embodiments of a medical infusion pump system include a pump device having a cap device that mates with a pump housing to retain a medicine cartridge therein. In addition to retaining the medicine cartridge in the pump housing, the cap device may perform a number of preparatory functions or safety functions. In addition or in the alternative, some embodiments of the pump device may include a drive system that advances a piston rod to dispense medicine to the patient in a safe and energy efficient manner.

Abstract: Apparatus are provided for infusion devices and related operating methods. An exemplary infusion device includes a housing to receive a shaft coupled to a plunger disposed in a reservoir and a gear assembly including a first gear to engage the shaft, wherein the first gear exhibits rotational freedom in a direction opposite a delivery direction. One exemplary method of operating the infusion device comprises identifying a reset condition and in response to the reset condition, operating a motor having a rotor coupled to the gear assembly to provide the rotational freedom for the first gear.

Abstract: Described here are methods, devices, and kits for microjet drug delivery. The devices described here may be modular or non-modular. The modular devices typically include a first module having a drug reservoir and a nozzle in fluid communication with the drug reservoir and a second module having an actuator and a power supply. The power supply provides power to the actuator and when the first and second modules are coupled, the actuator is capable of acting on a dispensing member causing it to dispense a drug in liquid form from the drug reservoir via the nozzle at a velocity sufficient to penetrate skin. Other devices described include a nozzle, a reservoir in fluid communication with the nozzle, a dispensing member, and an actuator. In these devices, the nozzle has at least one feature that enhances nozzle contact with the skin in order to reduce lateral drug leakage about the nozzle.

Abstract: A fluid flow system for a patient comprises a controller and an implantable pump assembly. The controller comprises a processing unit and a battery. The processing unit includes a signal generator and one or more pump operational parameters. The signal generator provides a drive signal. The battery provides power to the processing unit. The implantable pump assembly receives the drive signal from the processing unit and propels fluid based on the drive signal. The system includes a local communication device and a remote communication device that each include a unique identifier produced by a security key generator. The remote communication device includes a code generator that produces encrypted commands. The local communication device receives the encrypted commands and modifies a pump operational parameter of the processing unit based on the received encrypted command.

Abstract: An injection device for delivering a medicament to the human or animal body. The injection device comprising a housing, a piston rod for driving a bung of a medicament container, a drive mechanism including a motor for providing an output drive to the piston rod for delivering the medicament; and controller for controlling operation of the device.

Abstract: Disclosed is an electrical signal applicable multi-needle syringe. The present invention comprises: a hollow cylinder; a needle hub closely coupled to the rear end of the cylinder; a plurality of needles placed at regular intervals inside the cylinder in such a way that the front ends are further protruded compared with the front end of the cylinder and the drug which is injected through the needle hub is sucked through the rear ends; a first electrode stored inside the cylinder, and commonly connected to a part of the plurality of needles; and a second electrode stored inside the cylinder, and commonly connected with the rest of the plurality of needles. Therefore, it is possible to inject a drug and to simultaneously apply a high frequency directly into the skin through a multi-needle injected into the skin by applying a high frequency between the first electrode and the second electrode, thereby promoting the activation of the injected drug.

Abstract: An infusion pump for metering fluid flow through an delivery tube of an infusion tubing set has an internal occlusion clamp which clamps the delivery tube to prevent the free flow of fluid through the tube when access to the delivery tube in the infusion pump is possible. To release the delivery tube from the infusion pump, a slide clamp is manually used to release the occlusion clamp to an open, non-occluding position while simultaneously occluding the delivery tube to prevent the free flow of fluid.

Abstract: The present invention relates to a controller unit and methods for controlling an insulin pump. The controller unit includes a user input that receives a gain factor. The gain factor has been calculated based on historical data in relation to a patient. The controller unit includes a measurement input for receiving data representative of a measured blood glucose level for the patient. Processing logic of the controller unit is configured to apply the measured blood glucose level to a pancreatic beta-cell insulin secretion computational model to predict an insulin output level, apply the gain factor to the predicted insulin output level to determine a patient insulin deficiency level, and calculate a control signal for controlling the insulin output level of the insulin pump based on the patient insulin deficiency level. Methods are provided for optimizing the gain factor based on the historical data in relation to the patient.

Abstract: A one-time use cartridge for a CT or MRI syringe has a syringe body coupled to an adapter by flanges that are trapped by a locking tooth supported as part of a groove in a unitary adapter. One-time use is enhanced with one-way valves associated with the forward end of the syringe body. The one-way valves have coaxial inner and outer members with reversed roles for fluid inflow and outflow tubing connections. The valves operate under positive and negative pressure generated by the syringe piston.

Abstract: This invention provides a process for making 3?-O-allyl-dGTP-PC-Biodopy-FL-510, 3?-O-allyl-dATP-PC-ROX, 3?-O-allyl-dCTP-PC-Bodipy-650 and 3?-O-allyl-dUTP-PC-R6G, and related methods.

Abstract: Disclosed is a fluid dispensing device that includes at least one reservoir to hold the therapeutic fluid, at least one other unit requiring communication with ambient air, at least partly, to operate, and at least one housing defining an interior to retain the at least one reservoir and the at least one other unit. The at least one housing has at least one vent port formed on one or more of its walls. The at least one vent port is adapted to direct or communicate air to maintain pressure equilibrium between the air pressure in the interior of the at least one housing and the ambient air pressure outside the at least one housing, and provide communication with the ambient air to the at least one other unit requiring air to enable operation of the at least one other unit.

Abstract: Disclosed herein are cartridge assemblies that include coding features that help dedicate a medicament reservoir to specific injection devices. An exemplary cartridge assembly comprises a cylindrical inner surface for holding medicament and a cylindrical outer surface comprising at its proximal end one or more stops configured as coding elements protruding from the cylindrical outer surface. Each coding element is configured only to engage a corresponding coding feature on a dose setting and delivery mechanism, thereby allowing only the correct cartridge assembly to connect to the dose setting and delivery mechanism.

Abstract: According to one exemplary embodiment, a manipulator device includes a base, first and second linear slides, a drive link, a drive member, a driven member and an end effector. The elements of the manipulator device cooperate to constrain the end effector to rotate about a remote center of motion that is displaced from a proximal center of motion as the drive link moves a carriage of the second linear slide along an arcuate path.

Abstract: A hand-held injection device (2) for injection of a medicament from a first medicament cartridge (40), injection device comprising: a housing (4) being designed to be held in one hand of a user, the longitudinal direction of the housing (4) running between the thumb and the other fingers of the hand of the user, a drive mechanism (42) for selectively dispensing the medicament from the first medicament cartridge (40), a dial dose mechanism (12, 14), a control panel region (8) with at least two operation buttons (12, 14, 16) disposed therein for activating operation functions of the injection device (2), an electronic control unit for controlling the operation of the drive mechanism 42 in response to the dial dose mechanism (12,14) and a display panel (10), in which the required dosage to be dispensed is presented to the user on the display panel (10), wherein between two of the operation buttons (12, 14, 16) a recess is provided in the control panel region (8) and in that in the recess (R) a discrete butto

Abstract: Systems and methods for processing sensor data and end of life detection are provided. In some embodiments, a method for determining the end of life of a continuous analyte sensor includes evaluating a plurality of risk factors using an end of life function to determine an end of life status of the sensor and providing an output related to the end of life status of the sensor. The plurality of risk factors may be selected from the list including the number of days the sensor has been in use, whether there has been a decrease in signal sensitivity, whether there is a predetermined noise pattern, whether there is a predetermined oxygen concentration pattern, and error between reference BG values and EGV sensor values.

Abstract: A device for suctioning nasal secretions, including a nasal tip having an opening through which the nasal secretions are suctioned, a first pipe, a first end of which is connected to the nasal tip and the other end of which communicates via a first opening, and a second pipe, one end of which communicates via a second opening, and these two pipes form an angle no more than 90°, and the opening connected to the nasal tip is aligned with the second pipe and arranged with the air stream exiting the opening of the second pipe.

Abstract: Infusion systems for holding an infusion pump on the body of a user are provided. According to one embodiment, the infusion system includes: a carrier frame; a guiding member disposed on the carrier frame; and a linear guide on the infusion pump wherein, when the infusion pump is attached to the carrier frame, the guiding member and the linear guide mate with each other to hold the infusion pump in place.