Analysis And Testing Patents (Class 204/400)
  • Publication number: 20140174949
    Abstract: An electrochemical sensor comprising an electrode having a protective layer; conductive nanoparticles bound to the protective layer; a redox active species bound to the conductive nanoparticles; and a binding moiety capable of associating with an analyte, the binding moiety being associated with the redox active species bound to the conductive nanoparticles. Association of a binding moiety with the analyte modulates the electrochemistry of the redox active species.
    Type: Application
    Filed: February 28, 2014
    Publication date: June 26, 2014
    Applicant: NewSouth Innovations Pty Limited
    Inventors: Justin Gooding, Guozhen Liu
  • Publication number: 20140174924
    Abstract: The invention relates to electrodes for electrochemical analysis comprising: —an insulating surface; —carbon nanotubes situated on the insulating surface at a density of at least 0.1 ?mCNT Um?2; and —an electrically conducting material in electrical contact with the carbon nanotubes; wherein the carbon nanotubes cover an area of no more than about 5.0% of the insulating surface. Methods of making such electrodes and assay devices or kits with such electrodes, are also provided.
    Type: Application
    Filed: February 27, 2014
    Publication date: June 26, 2014
    Applicant: THE UNIVERSITY OF WARWICK
    Inventors: Julie Victoria Macpherson, Patrick Robert Unwin
  • Patent number: 8758584
    Abstract: Systems and methods are provided for detecting the presence of an analyte in a sample. A solid state electrochemical sensor can include a redox active moiety having an oxidation and/or reduction potential that is sensitive to the presence of an analyte immobilized over a surface of a working electrode. A redox active moiety having an oxidation and/or reduction potential that is insensitive to the presence of the analyte can be used for reference. Voltammetric measurements made using such systems can accurately determine the presence and/or concentration of the analyte in the sample. The solid state electrochemical sensor can be robust and not require calibration or re-calibration.
    Type: Grant
    Filed: December 16, 2011
    Date of Patent: June 24, 2014
    Assignee: Sensor Innovations, Inc.
    Inventors: Carolyn R. Kahn, Elicia Wong, James A. Wilkins, Vern Norviel
  • Patent number: 8747749
    Abstract: A precious metal testing apparatus and methods adapted to analyze impurities in a precious metal test sample is described. The testing apparatus contains a test probe that has a replaceable portion and that is connected to a meter to measure resistance. The replaceable portion contains or forms a reservoir that includes at least one electrolyte component, a conductive member, and a fibrous tip. The electrolyte component is fluidly associated with a fiber tip and the conductive member contacts an electrical contact located outside the reservoir. Methods of testing and instructions regarding such methods are also included.
    Type: Grant
    Filed: May 30, 2012
    Date of Patent: June 10, 2014
    Assignee: FMS Technologies, LLC
    Inventors: Michael R. Ebersole, Warren D. Kleinfelter
  • Publication number: 20140151220
    Abstract: The present invention provides an electrochemical sensing strip, comprising an electrochemical sensing strip body and an auxiliary support sheet disposed under the electrochemical sensing strip body. Compared to the prior art, the electrochemical sensing strip provided in the present invention has an auxiliary support sheet, which functions to support the electrochemical sensing strip body, so that the entire electrochemical sensing strip does not deform easily. Consequently, the resistance to bending of the electrochemical sensing strip is enhanced, and the occurrence of bending the electrochemical sensing strip during operation is reduced, and thus the test error of the electrochemical sensing strip is reduced.
    Type: Application
    Filed: November 22, 2013
    Publication date: June 5, 2014
    Applicant: Beijing Hong Yuan Xing Bang Technology Co., Ltd.
    Inventors: Chi-Yuang Lin, Yuanwu Wang
  • Publication number: 20140151224
    Abstract: Assay modules, preferably assay cartridges, are described as are reader apparatuses which may be used to control aspects of module operation. The modules preferably comprise a detection chamber with integrated electrodes that may be used for carrying out electrode induced luminescence measurements. Methods are described for immobilizing assay reagents in a controlled fashion on these electrodes and other surfaces. Assay modules and cartridges are also described that have a detection chamber, preferably having integrated electrodes, and other fluidic components which may include sample chambers, waste chambers, conduits, vents, bubble traps, reagent chambers, dry reagent pill zones and the like. In certain preferred embodiments, these modules are adapted to receive and analyze a sample collected on an applicator stick.
    Type: Application
    Filed: February 3, 2014
    Publication date: June 5, 2014
    Applicant: Meso Scale Technologies, LLC
    Inventors: Eli N. Glezer, Jonathan K. Leland, Mark A. Billadeau, Joseph M. Leginus, Bandele Jeffrey-Coker, Jeff D. Debad, Koustubh A. Phalnikar, Sriram Jambunathan
  • Publication number: 20140151225
    Abstract: An electrochemical detector is an electrochemical detector for detecting a substance in a liquid by generating a redox cycle, the electrochemical detector comprising: a first working electrode having a first electrode surface, a second working electrode having a second electrode surface, and a plurality of insulating spacer particles, wherein the first and second electrode surfaces are placed so as to face each other so that an electric field is formed between the first and second electrode surfaces, and the plurality of spacer particles are placed along the first and second electrode surfaces so as to separate the first and second electrode surfaces from each other.
    Type: Application
    Filed: December 12, 2012
    Publication date: June 5, 2014
    Applicant: Panasonic Corporation
    Inventors: Yoshihisa Yamashita, Seiichi Nakatani, Tetsuyoshi Ogura, Koichi Hirano, Makoto Takahashi, Satoshi Arimoto
  • Publication number: 20140151219
    Abstract: The silver electrode coated with carbon nanotubes is an indicator electrode for microtitrimetry by differential electrolytic potentiometry. The electrode is made by first positioning at least one silver wire electrode within a reaction zone of a floating catalyst chemical vapor deposition reactor. A ferrocene catalyst is evaporated within the floating catalyst chemical vapor deposition reactor, and an inlet gas is fed therein to carry the evaporated ferrocene catalyst into the reaction zone. The inlet gas includes hydrogen and a carbon source, such as acetylene. The reaction zone is then heated for deposition of carbon onto the at least one silver electrode to form at least one silver electrode coated with carbon nanotubes. The electrode is cooled and then removed from the reactor.
    Type: Application
    Filed: December 4, 2012
    Publication date: June 5, 2014
    Applicant: KING FAHD UNIVERSITY OF PETROLEUM AND MINERALS
    Inventors: ABDALLA M. ABULKIBASH, MOATAZ ALI ATEIEH, ABDULAZIZ NABIL AMRO
  • Patent number: 8741117
    Abstract: Described herein is a device comprising a plurality of first reaction electrodes arranged in an array, the plurality of first reaction electrodes configured to be exposed to a solution and having a capacitance; first circuitry configured to controllably connect the plurality of first reaction electrodes to a bias source and controllably disconnect the plurality of first reaction electrodes from the bias source; and second circuitry configured to measure a rate of charging or discharging of the capacitance. Also described herein is a method of using this device to sequence DNA.
    Type: Grant
    Filed: September 27, 2012
    Date of Patent: June 3, 2014
    Assignee: Intel Corporation
    Inventors: Jonathan S. Daniels, Oguz H. Elibol, Grace M. Credo, Xing Su
  • Publication number: 20140147913
    Abstract: The invention concerns a test element analytical system for the analytical examination of a sample, especially a body fluid, comprising at least one test element with one or more measuring zones and contact areas located on the test element, in particular electrodes or conductor paths, the sample to be examined being brought into the measuring zone to carry out an analysis in order to determine a characteristic measured quantity for the analysis, and an evaluation instrument with a test element holder for positioning the test element in a measuring position and a measuring device for measuring the characteristic change, the test element holder containing contact elements with contact areas which enable an electrical contact between the contact areas of the test element and the contact areas of the test element holder, characterized in that one of these contact areas is provided with an electrically conductive hard material surface.
    Type: Application
    Filed: January 29, 2014
    Publication date: May 29, 2014
    Applicant: Roche Diagnostics Operations, inc.
    Inventors: Manfred Augstein, Joerg Dreibholz, Stefan Riebel
  • Patent number: 8728288
    Abstract: The invention relates to a sensor assembly comprising a first electronic wiring substrate having a first and a second surface and at least one analyte sensor formed on the first surface thereof, the at least one analyte sensor being connected with one or more electrical contact points, a second electronic wiring substrate having a first and a second surface and at least one analyte sensor formed on the first surface part thereof, the at least one analyte sensor being connected with one or more electrical contact points, and a spacer having a through-going recess with a first and a second opening, wherein the first substrate, the second substrate and the spacer are arranged in a layered structure, where the first surface of the first substrate closes the first opening of the spacer and the first surface of the second substrate closes the second opening of the spacer, thereby forming a measuring cell which is faced by at least one sensor from each of the substrates.
    Type: Grant
    Filed: April 24, 2008
    Date of Patent: May 20, 2014
    Assignee: Radiometer Medical Aps
    Inventors: Flemming Aas, Erik Helleso Nicolajsen
  • Publication number: 20140131199
    Abstract: In some aspects, a modular analyte measurement system having a replaceable strip port module is provided to permit contaminated modules to be replaced. Some aspects of the present disclosure related to barriers for strip ports or the sealing of strip ports and/or analyte measurement devices to maintain a clean strip port and/or enable the strip port to be cleaned for reuse. Cleaning tools are also provided. Also provided are strip port interfaces that guide fluid away from the strip port opening, as well as absorptive elements that prevent fluid from entering a strip port. Analyte measurement devices with gravity sensors or accelerometers are also provided, along with methods related thereto. Also provided are docking station that serve as an information server and provides storage and recharging capabilities.
    Type: Application
    Filed: January 16, 2014
    Publication date: May 15, 2014
    Applicant: Abbott Diabetes Care Inc.
    Inventors: Matthew Simmons, Cherie Bulala, Christopher Myles, Bonita Park Song
  • Patent number: 8722413
    Abstract: An automated system and process for the titration of either Waste vegetable oil (WVO) or virgin vegetable oil during its chemical conversion into Biodiesel. A system capable of automatically measuring and controlling the addition of a suitable amount of titration fluid is controlled in reaction to a pH level measurement tool, as determined by sensors and software. The process comprises forming a single phase solution of WVO and titrant in a ratio of between 10:1 to 50:1.
    Type: Grant
    Filed: August 22, 2011
    Date of Patent: May 13, 2014
    Inventors: Jimmy Gracia, Anthony Troy Hardtke, Eric Tallent
  • Patent number: 8721850
    Abstract: A biosensor for detecting an analyte in a sample of body fluid and methods for manufacturing the biosensor are disclosed. In one embodiment, a biosensor includes at least two electrical conductors embedded within an electrically insulating test element body. The electrical conductors are exposed at two ends of the test element body and a reagent, for example a reagent adapted to test for blood glucose, is applied to one end. In one form, the test element body is cylindrical with a circular or non-circular cross-sectional shape. In other embodiments, the test elements are manufactured by a resin pultrusion process in which resin embedded with electrical conductors is dried or cured, shaped and cut into segments, and reagent applied to one end of each segment.
    Type: Grant
    Filed: February 2, 2010
    Date of Patent: May 13, 2014
    Assignee: Roche Diagnostics Operations, Inc.
    Inventor: Matthew Carlyle Sauers
  • Patent number: 8709224
    Abstract: Methods for the detection of biologically relevant molecules that comprise concentrating such molecules into microscopic holes in a sheet of chemically inert material, restricting the openings, and measuring the electric current through the holes or the fluorescence near the hole openings. The electric current or fluorescence will change as the molecules diffuse out of the holes, providing a measure of the diffusion rate and thereby detecting the presence and characteristics of the molecules. For molecules that interact, the diffusion rate will be slower than for molecules that do not interact, yielding a determination of the molecular interaction. Capping the population of holes and inserting into a mass spectrometer allows identification of the molecules.
    Type: Grant
    Filed: February 15, 2011
    Date of Patent: April 29, 2014
    Inventor: Christopher Gordon Atwood
  • Publication number: 20140110274
    Abstract: A method of producing porous ionic conducting material, comprising the step of positioning an ionic substance into cellulosic material to form a continuous web or at least one individual sheet of porous ionic cellulosic based material, comprising the steps of first producing a web or sheet shaped cellulosic based substrate and thereafter applying liquid comprising room temperature ionic liquids. The porous ionic conducting material is used in flexible electronic device, by using the material as a substrate and applying a conducting material. A sensor assembly for sensing a property of an object, comprising at least one sensor wherein said sensor assembly comprises a flexible web or sheet shaped material. An authentication device for verifying the authenticity of an object. The device comprising at least one flexible electronic device.
    Type: Application
    Filed: May 14, 2012
    Publication date: April 24, 2014
    Inventors: Magnus Lestelius, Elson Montibon, Lars Järnström
  • Patent number: 8702958
    Abstract: A method is provided for determining the presence or amount of an analyte in a sample and includes the steps of contacting a faradaic working electrode to a solution comprising the optionally pre-processed sample and an electrolyte, contacting a capacitive counter electrode to the solution, supplying electrical energy between the faradaic working electrode and the capacitive counter electrode sufficient to provide for faradaic charge transfer at the faradaic working electrode, and measuring at least one of (i) light, (ii) current, (iii) voltage, and (iv) charge to determine the presence or amount of the analyte in the sample.
    Type: Grant
    Filed: May 31, 2012
    Date of Patent: April 22, 2014
    Assignee: Board of Regents of the University of Texas System
    Inventors: Allen J. Bard, Chong-Yang Liu
  • Patent number: 8702930
    Abstract: A sensor chip is a sensor device for measuring a property of a substance by adsorbing the substance on a surface of the sensor chip. The sensor chip includes a diaphragm having a first surface, a second surface, and at least one through hole penetrating from the first surface to the second surface. At least a part of the first surface, the second surface, and an inner wall surface of the through hole is covered with a noncrystalline solid layer including SiOX as a main component, in which substance X is an element having higher electronegativity than that of silicon.
    Type: Grant
    Filed: January 11, 2012
    Date of Patent: April 22, 2014
    Assignee: Panasonic Corporation
    Inventors: Kiyoshi Hashimotodani, Yusuke Nakano, Masaya Nakatani, Takeki Yamamoto, Yoshiki Yamada, Takuya Oka, Hiroshi Ushio
  • Patent number: 8702933
    Abstract: A potentiometric sensor with suppressed leak current on the surface of an electrode and improved for a dynamic range and a response speed, in which a redox compound is immobilized through insulative molecules on the surface of a gold electrode, and a current between a source and drain of an insulated gate field-effect transistor along with reaction between an oxidized substance or a reduced substance produced by the reaction of a measured substance in a sample solution injector for supplying the sample solution containing the measured substance and an enzyme and a redox compound on the surface of the gold electrode, is monitored on real time to measure the change of the surface potential.
    Type: Grant
    Filed: June 14, 2012
    Date of Patent: April 22, 2014
    Assignee: Hitachi, Ltd.
    Inventors: Yu Ishige, Masao Kamahori
  • Patent number: 8702948
    Abstract: Disclosed are a method and apparatus that use an electric field for improved biological assays. The electric field is applied across a device having wells, which receive reactants, which carry a charge. The device thus uses a controllable voltage source between the first and second electrodes, which is controllable to provide a positive charge and a negative charge to a given electrode. By controlled use of the electric field charged species in a fluid in a fluid channel are directed into or out of the well by an electric field between the electrodes. The present method involves the transport of fluids, as in a microfluidic device, and the electric field-induced movement of reactive species according to various assay procedures, such as DNA sequencing, synthesis or the like.
    Type: Grant
    Filed: September 14, 2012
    Date of Patent: April 22, 2014
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Mostafa Ronaghi, Tarun Khurana, Juan G. Santiago
  • Patent number: 8702922
    Abstract: The cell observation using a conventional well plate takes much costs. Each well 3 being opened at a top plate 2a of the well plate 1 has a diameter reduced portion 32 which inner circumferential surface 32a is conically hollowed. At a lower portion of the diameter reduced portion 32 is formed an inserting hole 33. In a detecting portion 4, an outer circumferential surface of a round-bar reference electrode 41 is covered by an insulating portion 42. The detecting portion 4 has an upper end portion 4a and a lower end portion 4b which outer circumferential surface is exposed to an outside without being covered by an insulating portion 42. On an upper side above the lower end portion 4b is formed a diameter expanded portion 4c in which an outer circumferential surface of the insulating portion 42 is covered with a measuring electrode 43. The detecting portion 4 is fixed to a well 3 whose diameter expanded portion 4c is inserted into an inserting hole 33 and its upper end portion 4a is contained in the well 3.
    Type: Grant
    Filed: September 17, 2008
    Date of Patent: April 22, 2014
    Assignee: ReproCELL, Inc.
    Inventors: Yasuyuki Asai, Makoto Nagakura, Takeaki Fukami, Keisuke Oosumi
  • Publication number: 20140106957
    Abstract: This disclosure relates to a method of densifying a lanthanide chromite ceramic or a mixture containing a lanthanide chromite ceramic. The method comprises mixing one or more lanthanide chromite ceramics with one or more sintering aids, and sintering the mixture. The one or more lanthanide chromite ceramics are represented by the formula (Ln1-xAEx)zCr1-yByO3-?, wherein Ln is a lanthanide element or yttrium, AE is one or more alkaline earth elements, B is one or more transition metals, x is a value less than 1, y is a value less than or equal to 0.5, and z is a value from 0.8 to 1.2. The sintering aids comprise one or more spinel oxides. The one or more spinel oxides are represented by the formula AB2O4 or A2BO4 wherein A and B are cationic materials having an affinity for B-site occupancy in a lanthanide chromite ceramic structure, e.g., ZnMn2O4, MgMn2O4, MnMn2O4 and CoMn2O4. This disclosure also relates in part to products, e.g., dense ceramic structures produced by the above method.
    Type: Application
    Filed: February 23, 2012
    Publication date: April 17, 2014
    Applicant: PRAXAIR TECHNOLOGY INC
    Inventors: Matthew M. Seabaugh, Scott Lawrence Swartz
  • Publication number: 20140102897
    Abstract: Disclosed herein are embodiments of an apparatus for analysis of electrochemical dissolution. One embodiment comprises a working electrode submerged in a first reaction chamber containing liquid electrolyte, a counter electrode submerged in a second reaction chamber containing liquid electrolyte, a reference electrode submerged in a third reaction chamber and electrolytically connected to the working electrode and an ion conductor electrolytically connecting the first reaction chamber and the second reaction chamber while physically separating the first reaction chamber and the second reaction chamber.
    Type: Application
    Filed: October 12, 2012
    Publication date: April 17, 2014
    Applicant: NISSAN NORTH AMERICA, INC.
    Inventors: Gregory Jerkiewicz, Kevork Adjemian, Diane Beauchemin, Liyan Xing, Mohammad Hossain
  • Patent number: 8695355
    Abstract: A heating/cooling device for a microfluidic apparatus having a thermal insulating substrate. The device includes heating/cooling chamber for heating and/or cooling a sample disposed in the chamber; a waste heat channel for carrying away waste heat and/or waste cooling; and at least one Peltier junction having first and second opposing faces, the first face thereof facing towards said heating/cooling chamber and being in thermal communication therewith for providing either heat or cooling to the chamber in response to a flow of electrical current through the at least one Peltier junction, the second face thereof facing towards said waste heat channel and being in thermal communication therewith for either receiving heat from or dumping heat to the channel in response to a flow of electrical current through the Peltier junction.
    Type: Grant
    Filed: December 7, 2005
    Date of Patent: April 15, 2014
    Assignee: California Institute of Technology
    Inventors: George Maltezos, Matthew Johnston, Axel Scherer
  • Patent number: 8685227
    Abstract: The invention refers to a sample fluid testing device for analyzing a sample fluid, comprising a test media tape (1) comprising a tape (2) and a plurality of test media portions (3), each test media portion (3) containing a sensor field (7) for producing electrical signals, when the sample fluid is applied and at least two electrodes (4), the at least two electrodes (4) being positioned in the sensor field (7) and being electrically connected to at least two contact fields (5). The sample fluid testing device contains at least one roller with a surface (17), which contains at least one contact zone (14), the at least one roller (12, 13) being in rolling engagement with the test media tape (1) with its surface (17) in order to successively electrically contact the test media portions (3) via at least one contact field (5) with the at least one contact zone (14), the at least one contact zone (14) on the at least one roller (12, 13) being electrically connected to a meter for measuring the electrical signals.
    Type: Grant
    Filed: October 24, 2008
    Date of Patent: April 1, 2014
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Hans List, Michael Marquant, Steven N. Roe
  • Publication number: 20140083848
    Abstract: A test sensor includes a body, a first conductive trace, a second conductive trace, and a third conductive trace. The body includes a first region that has a fluid-receiving area, a second region separate from the first region, and a first temperature sensing interface disposed at or adjacent to the fluid-receiving area. The fluid-receiving area receives a sample. The first trace is disposed on the body, and at least a portion of the first trace is disposed in the first region. The second and third traces are disposed on the body. The third trace extends from the first to the second regions. The third trace is connected to the first trace at the first temperature sensing interface. The third trace includes a different material than the first trace. A first thermocouple is formed at the first temperature sensing interface. The thermocouple provides temperature data to determine an analyte concentration.
    Type: Application
    Filed: December 2, 2013
    Publication date: March 27, 2014
    Applicant: Bayer HealthCare LLC
    Inventors: Steve Hoi-Cheong Sun, Swetha Chinnayelka, John P. Creaven, Andrew J. Edelbrock, Matthew B. Holzer, Narasinha C. Parasnis, Jeffery S. Reynolds, Paul M. Ripley, Steven C. Charlton, Xin Wang, Mu Wu
  • Patent number: 8673126
    Abstract: A DYNAMIC PRECIOUS METAL ASSAY DEVICE is described which is based on the methodology of the parent patent DYNAMIC PRECIOUS METAL ASSAY METHOD, U.S. Pat. No. 4,799,999 and achieves a highly accurate gold assay with a range extended to over 24 karats. The specified device requires a manual expulsion of a small amount of electrolyte from a disposable cartridge into a miniature galvanic cell which is formed at the lower tip of the device pencil. Placing the said tip against a gold specimen under test, thereby wetting it, and then by initiating the charging cycle and interpolating algorithm in the external electronics results in a professionally accurate assay of the gold specimen under test. The superior performance of this device is attributed to the novel replaceable electrolytic cartridge and miniature galvanic cell which wets a specimen through a porous interface. This improved device is very stable, rugged and is easily maintained.
    Type: Grant
    Filed: February 27, 2012
    Date of Patent: March 18, 2014
    Assignee: Tri Electronics, Inc
    Inventors: Leonid Radomyshelsky, Boris Loginov
  • Publication number: 20140042037
    Abstract: Methods and devices for analyzing a chemical analyte using an electrochemical cell connected to a measuring apparatus are provided. The electrochemical cell contains a solution having one or more conductive or redox active NPs, one or more chemical analytes, and an indicator. In addition, the electrochemical cell contains one or more electrodes in communication with the solution. One or more catalytic ECL properties are generated by the interaction of the one or more conductive or redox active NPs and the liquid sample and measured at the one or more electrodes or with an optical detection system.
    Type: Application
    Filed: October 17, 2013
    Publication date: February 13, 2014
    Inventors: Fu-Ren F. Fan, Allen J. Bard, Xiaoying Xiao
  • Patent number: 8643377
    Abstract: A method of detecting impurities in a high-temperature aqueous solution and an apparatus of detecting impurities for the same. Specifically, the present invention provides a method of detecting impurities in a high-temperature aqueous solution comprising a reducing agent using an electrochemical water chemistry technology detecting the electrochemical current varied according to the degree in which the impurities in the high-temperature aqueous solution hinder the formation of an oxide film that is formed on a noble metal electrode, and an impurity detecting apparatus comprising a noble metal electrode, a counter electrode, and a device of applying the electrochemical potential and measuring the electrochemical current for the method of detecting impurities.
    Type: Grant
    Filed: December 8, 2010
    Date of Patent: February 4, 2014
    Assignee: Korea Atomic Energy Research Institute
    Inventors: Jei-Won Yeon, Kyuseok Song, Jaesik Hwang, Myung Hee Yun
  • Patent number: 8636883
    Abstract: A remotely readable hydrogen detector is in the form of a tag or card that can be worn on clothing or mounted on a variety of surfaces and can be monitored from a distance for the presence of hydrogen gas. It includes a hydrogen sensor device, which changes in electrical resistivity in response to being exposed to hydrogen gas, that is incorporated into an electric detector circuit, which detects changes in resistivity of the sensor device, and, when such change in resistivity indicates the presence of some predetermined concentration of hydrogen gas, the electric circuit outputs a signal or state that indicates the presence of hydrogen to a transceiver circuit, which can transmit that information to a remote receiver or interrogator/reader via an antenna in the sensor device.
    Type: Grant
    Filed: March 12, 2007
    Date of Patent: January 28, 2014
    Assignee: Element One, Inc.
    Inventors: William Hoagland, David K. Benson
  • Publication number: 20140014506
    Abstract: Apparatus for sensing an analyte, the analyte being bound to at least one magnetic particle to form a labelled analyte, and wherein the apparatus includes a cavity having a sensor therein, wherein in use the cavity contains a fluid and at least one labelled analyte and a magnet system for generating a magnetic field having a field direction substantially orthogonal to at least part of the cavity to orientate the at least one labelled analyte in the cavity and a field gradient along at least part of the cavity to thereby urge the at least one labelled analyte along the cavity towards the sensor.
    Type: Application
    Filed: December 14, 2011
    Publication date: January 16, 2014
    Applicant: THE UNIVERSITY OF QUEENSLAND
    Inventor: Krassen Dimitrov
  • Publication number: 20140014507
    Abstract: The present disclosure relates to a probe capable of electrochemical and Raman spectroscopic monitoring wherein a Raman-active gold microshell having conductivity is attached to the tip of a glass microcapillary tube in which a conductive material is coated on an inner wall thereof by electroless plating. By coupling the probe with a system capable of moving the probe, the activities of various catalyst materials can be detected quickly and information of intermediate products moving from and adsorbed on the surface can be provided.
    Type: Application
    Filed: March 29, 2011
    Publication date: January 16, 2014
    Applicant: SNU R&DB FOUNDATION
    Inventors: Taek Dong Chung, Beom Jin Kim
  • Patent number: 8623660
    Abstract: A hand-held test meter for use with an analytical test strip in the determination of an analyte in a bodily fluid sample includes a housing; a microcontroller block disposed in the housing; and a phase-shift-based hematocrit measurement block. The phase-shift-based hematocrit measurement block includes a signal generation sub-block, a low pass filter sub-block, an analytical test strip sample cell interface sub-block, a transimpedance amplifier sub-block, and a phase detector sub-block. In addition, the phase-shift-based hematocrit measurement block and microcontroller block are configured to measure the phase shift of a bodily fluid sample in a sample cell of an analytical test strip inserted in the hand-held test meter and the microcontroller block is configured to compute the hematocrit of the bodily fluid sample based on the measured phase shift.
    Type: Grant
    Filed: September 30, 2011
    Date of Patent: January 7, 2014
    Assignee: LifeScan Scotland Limited
    Inventors: Ulrich Kraft, David Elder, Mahyar Kermani
  • Patent number: 8623183
    Abstract: An electrode module includes a working electrode, a counter electrode, a reference electrode and a well (container) for retaining an electrolytic solution and is used in electrochemical measuring instruments. This electrode module is produced by integrating the well with at least one of the working electrode, the counter electrode and the reference electrode. This integrated electrode includes a chip-like electrode having a thin membrane of an electrode material formed on the surface of a chip-like base metal. This chip-like electrode is disposed on and integrated with the bottom of the well in a detachable manner. There is provided the compact, low price electrode module of high repetition use efficiency with no need of maintenance and having easy handling.
    Type: Grant
    Filed: April 2, 2009
    Date of Patent: January 7, 2014
    Assignee: Kyushu Institute of Technology
    Inventors: Shigeori Takenaka, Yoshiaki Hano, Minoru Yamada, Kimio Morimoto, Hiroshi Endo, Hiroshi Yasutake, Shinobu Sato, Keiichi Otsuka
  • Patent number: 8617364
    Abstract: An electrochemical sensor includes a polymeric housing and at least a first electrode within the housing. The first electrode includes an electrochemically active surface. The electrochemical sensor further includes a first connector in electrically conductive connection with the first electrode. The first connector includes a first extending member formed from a conductive loaded polymeric material. The first extending member is formed such that an interior thereof comprises conductive elements within a matrix of the polymeric material so that the interior is electrically conductive and an exterior surface thereof comprises the polymeric material and is less conductive than the conductive interior. The conductive interior of the first extending member is in electrically conductive connection with the first electrode. The first connector further includes a first extending conductive element in electrical connection with the conductive interior.
    Type: Grant
    Filed: August 29, 2011
    Date of Patent: December 31, 2013
    Assignee: Mine Safety Appliances Company
    Inventors: Michael Alvin Brown, Brian Keith Davis, Towner Bennet Scheffler
  • Patent number: 8617381
    Abstract: A test sensor includes a body, a first conductive trace, a second conductive trace, and a third conductive trace. The body includes a first region that has a fluid-receiving area, a second region separate from the first region, and a first temperature sensing interface disposed at or adjacent to the fluid-receiving area. The fluid-receiving area receives a sample. The first trace is disposed on the body, and at least a portion of the first trace is disposed in the first region. The second and third traces are disposed on the body. The third trace extends from the first to the second regions. The third trace is connected to the first trace at the first temperature sensing interface. The third trace includes a different material than the first trace. A first thermocouple is formed at the first temperature sensing interface. The thermocouple provides temperature data to determine an analyte concentration.
    Type: Grant
    Filed: June 23, 2010
    Date of Patent: December 31, 2013
    Assignee: Bayer Healthcare LLC
    Inventors: Steve Hoi-Cheong Sun, Swetha Chinnayelka, John P. Creaven, Andrew J. Edelbrock, Matthew B. Holzer, Narasinha C. Parasnis, Jeffery S. Reynolds, Paul M. Ripley, Steven C. Charlton, Xin Wang, Mu Wu
  • Publication number: 20130343955
    Abstract: The invention relates to a cartridge housing for forming a cartridge capable of measuring an analyte or property of a liquid sample. The housing including a top portion having a first substantially rigid zone and a substantially flexible zone, a bottom portion separate from the top portion including a second substantially rigid zone, and at least one sensor recess containing a sensor. The top portion and the bottom portion are bonded to form the cartridge having a conduit over at least a portion of the sensor. The invention also relates to methods for forming such cartridges and to various features of such cartridges.
    Type: Application
    Filed: June 22, 2012
    Publication date: December 26, 2013
    Applicant: ABBOTT POINT OF CARE INC.
    Inventors: Kevin John DOYLE, Paul WILKINS, Mick WITHERS, Adrian COOPER, John Oakey NOELL
  • Patent number: 8613842
    Abstract: A layered electrocatalyst for oxidizing ammonia, ethanol, or combinations thereof, comprising: a carbon support integrated with a conductive metal; at least one first metal plating layer at least partially deposited on the carbon support, wherein the at least one first metal plating layer is active to OH adsorption and inactive to a target species, and wherein the at least one first metal plating layer has a thickness ranging from 10 nanometers to 10 microns; and at least one second metal plating layer at least partially deposited on the at least one first metal plating layer, wherein the at least one second metal plating layer is active to the target species, and wherein the at least one second metal plating layer has a thickness ranging from 10 nanometers to 10 microns, forming a layered electrocatalyst.
    Type: Grant
    Filed: July 9, 2012
    Date of Patent: December 24, 2013
    Assignee: Ohio University
    Inventor: Gerardine G. Botte
  • Patent number: 8602992
    Abstract: A sensor system includes a sensor and a sensor electronics device. The sensor includes a plurality of electrodes. The sensor electronics device includes a connection detection device, a power source, and a delay circuit. The connection detection device determines if the sensor electronics device is connected to the sensor and transmits a connection signal. The delay circuit receives the connection signal, waits a preset hydration time, and couples the regulated voltage from the power source to an electrode in the sensor after the preset hydration time has elapsed. Alternatively, the sensor electronics device may include an electrical detection circuit and a microcontroller. The electrical detection circuit determines if the plurality of electrodes are hydrated and generates an interrupt if the electrodes are hydrated. A microcontroller receives the interrupt and transmits a signal representative of a voltage to an electrode of the plurality of electrodes.
    Type: Grant
    Filed: September 21, 2010
    Date of Patent: December 10, 2013
    Assignee: Medtronic Minimed, Inc.
    Inventors: Rajiv Shah, Wayne A. Morgan, David Y. Choy, James L. Henke, Bahar Reghabi, Gopikrishnan Soundararajan, Peter Schultz, Udo Hoss
  • Patent number: 8597480
    Abstract: Devices and methods are provided for determining the concentration of a reduced form of a redox species. For example, a device can include a working electrode and a counter electrode spaced by a predetermined distance so that reaction produces from the counter electrode arrive at the working electrode. An electric potential difference can be applied between the electrodes, and the potential of the working electrode can be selected such that the rate of electro-oxidation of the reduced form of the species is diffusion controlled. Current as a function of time can be determined, the magnitude of the steady state current can be estimated, and a value indicative of the diffusion coefficient and/or of the concentration of the reduced form of the species can be obtained from the change in current with time and the magnitude of the steady state current. Other embodiments of apparatuses, devices, and methods are also provided.
    Type: Grant
    Filed: January 24, 2012
    Date of Patent: December 3, 2013
    Assignee: LifeScan, Inc.
    Inventors: Alastair McIndoe Hodges, Thomas William Beck, Oddvar Johansen
  • Publication number: 20130313129
    Abstract: Provided are: a method of measuring the total concentration of oxidizing agents, by which the total concentration can be determined in a single measurement with simple operations even in an evaluation solution containing multiple components such as persulfuric acid, perosulfate and hydrogen peroxide; a simple and inexpensive concentration meter for measuring the total concentration of oxidizing agents; and a sulfuric acid electrolysis device comprising the concentration meter. The method according to the present invention is a method of measuring the total concentration of oxidizing agent(s) in an evaluation solution containing at least one oxidizing agent. The method comprises at least the steps of: heat-treating the evaluation solution at 50 to 135° C.; and detecting hydrogen peroxide in the thus heat-treated evaluation solution.
    Type: Application
    Filed: February 27, 2012
    Publication date: November 28, 2013
    Applicant: CHLORINE ENGINEERS CORP., LTD.
    Inventors: Junko Kosaka, Masaaki Kato, Hiroki Domon
  • Patent number: 8591416
    Abstract: A sensor system includes a sensor and a sensor electronics device. The sensor includes a plurality of electrodes. The sensor electronics device includes a connection detection device, a power source, and a delay circuit. The connection detection device determines if the sensor electronics device is connected to the sensor and transmits a connection signal. The delay circuit receives the connection signal, waits a preset hydration time, and couples the regulated voltage from the power source to an electrode in the sensor after the preset hydration time has elapsed. Alternatively, the sensor electronics device may include an electrical detection circuit and a microcontroller. The electrical detection circuit determines if the plurality of electrodes are hydrated and generates an interrupt if the electrodes are hydrated. A microcontroller receives the interrupt and transmits a signal representative of a voltage to an electrode of the plurality of electrodes.
    Type: Grant
    Filed: September 21, 2010
    Date of Patent: November 26, 2013
    Assignee: Medtronic Minimed, Inc.
    Inventors: Rajiv Shah, Wayne A. Morgan, David Y. Choy, James L. Henke, Bahar Reghabi, Gopikrishnan Soundararajan, Peter Schultz, Udo Hoss
  • Patent number: 8586378
    Abstract: Methods, compositions and kits for analyzing a chemical analyte using an electrochemical cell connected to a measuring apparatus are provided. The electrochemical cell contains a solution having one or more conductive or redox active NPs (nanoparticles), one or more chemical analytes, and an indicator. In addition, the electrochemical cell contains one or more electrodes in communication with the solution. One or more catalytic ECL properties are generated by the interaction of the one or more conductive or redox active NPs and the liquid sample and measured at the one or more electrodes or with an optical detection system.
    Type: Grant
    Filed: April 7, 2009
    Date of Patent: November 19, 2013
    Assignee: Board of Regents, The University of Texas System
    Inventors: Fu-Ren F. Fan, Allen J. Bard, Xiaoyin Xiao
  • Patent number: 8586351
    Abstract: A hybridization detecting device, wherein a probe cell has a body of semiconductor material forming a diaphragm, a first electrode on the diaphragm, a piezoelectric region on the first electrode, a second electrode on the piezoelectric region and a detection layer on the second electrode. The body accommodates a buried cavity downwardly delimiting the diaphragm.
    Type: Grant
    Filed: December 29, 2009
    Date of Patent: November 19, 2013
    Assignee: STMicroelectronics S.r.l.
    Inventors: Flavio Francesco Villa, Ubaldo Mastromatteo, Gabriele Barlocchi
  • Patent number: 8585878
    Abstract: An apparatus and method for electrochemical fluid analysis comprises a chamber (1202) having a depth dimension for accommodating a volume of a fluid under test, first and second electrodes (A1) disposed within the chamber and extending along the depth dimension in spaced relation with each other, and a soluble solid, such as an annealed polymer, e.g. EUDRAGIT occupying a lateral gap between the first and second electrodes. The rate of dissolution as monitored by electrochemical impedance spectroscopy (EIS) of the soluble solid within the fluid depends on the chemical concentration of a corresponding analyte present in solution in the fluid. In one embodiment a silicon-based integrated circuit device defining an upper margin includes an array of electrodes disposed along said upper margin to permit direct exposure of the electrode array to the fluid under test. The device is constructed using CMOS technology.
    Type: Grant
    Filed: August 29, 2008
    Date of Patent: November 19, 2013
    Assignee: MEDIMETRICS Personalized Drug Delivery B.V.
    Inventors: Lucian R. Albu, Hans Zou, Jeff Shimizu
  • Patent number: 8568575
    Abstract: An adjustable insertion assembly for an electrochemical sensor includes an electrode holder to receive the sensor, having a distal aperture to permit process fluid to contact the sensor. A receptacle slidably receives the holder, for a sliding range of motion extending from fully inserted to fully retracted positions. An open distal end portion of the receptacle extends through a wall of a process fluid vessel, so that the aperture is open to the process fluid when fully inserted, and closed when fully retracted. A leverage member is releasably movable relative to the receptacle, and moves with a captured extension. An abutment of the receptacle engages the extension so that movement of the leverage member in opposite directions alternately clamps and releases the electrode holder relative to the receptacle to substantially prevent and permit movement at substantially any point within the range of movement.
    Type: Grant
    Filed: July 23, 2010
    Date of Patent: October 29, 2013
    Assignee: Invensys Systems, Inc.
    Inventor: Stephen B. Talutis
  • Patent number: 8568578
    Abstract: An object of the present invention is to provide an electrode for an electrochemical measurement apparatus that is less susceptible to influence from interference substances as compared to conventional technology and an electrochemical measurement apparatus using such an electrode. A working electrode 9 (an electrode 1 for an electrochemical measurement apparatus) used in an electrochemical measurement apparatus 3 of the present invention uses an alloy containing iridium and rhenium with such a composition that selectivity for hydrogen peroxide can be obtained.
    Type: Grant
    Filed: October 29, 2008
    Date of Patent: October 29, 2013
    Assignees: NEC Corporation, National Institute for Materials Science
    Inventors: Toru Matsumoto, Naoaki Sata, Yoko Mitarai
  • Patent number: 8568825
    Abstract: A sensor for the simultaneous detection of inorganic contaminants, As (III), Hg (II) and Cu (II) in water and having a limit of detection of 0.02 ppb, comprising a conducting support having a layer comprised of a three dimensional silicate network comprised of thiol tail groups immobilized with citrate stabilized gold nanoparticles, wherein the gold nanoparticles have a size in the range of 70 to 100 nm.
    Type: Grant
    Filed: April 21, 2009
    Date of Patent: October 29, 2013
    Assignee: Indian Institute of Technology
    Inventors: C. Retna Raj, Bikash Kumar Jena
  • Publication number: 20130277236
    Abstract: Process and device for measuring the conversion of mercaptans to disulfides, in which the progress of the reaction for producing disulfides is monitored by measuring the redox potential.
    Type: Application
    Filed: November 22, 2011
    Publication date: October 24, 2013
    Applicant: TOTAL RAFFINAGE MARKETING
    Inventors: Christophe Hein, Alain Houlier
  • Publication number: 20130277215
    Abstract: The present invention relates to diagnostic devices incorporating electrode modules and fluidics for performing chemical analyses. The invented devices consist of at least one component sensor formed on an electrode module, the sensor being contained within a fluidic housing. The electrode module is a laminate of a perforated epoxy foil and a photo-formed metal foil with sensor membranes deposited into the perforations. The fluidic housing is a diagnostic card consisting of a plastic card-like body, the at least one component sensor, a sealed chamber defined in the card body for containing a fluid, a fluid conduit for fluidically connecting the chamber with the sensor region, a valve for fluidically connecting the chamber to the fluid conduit, and a delivery structure separate and distinct from the valve for forcing fluid from the chamber and into the fluid conduit.
    Type: Application
    Filed: June 21, 2013
    Publication date: October 24, 2013
    Inventors: Imants LAUKS, Andrzej MACZUSZENKO