Abstract: A blood-sampling tube with a first fluid-receiving chamber for receiving a fluid is described, where the first fluid-receiving chamber may be connected to at least one fluid channel that has a sensor device for measuring at least one biochemical function of the fluid passed through the fluid channel, where the measured biochemical function of the fluid may be read out from the sensor device via a data interface of the blood-sampling tube.

Abstract: Devices for the local delivery of microdose amounts of one or more active agents, alone or in combination, in one or more dosages, to selected tissue of a patient are described. The devices generally include multiple microwells arranged on or within a support structure and contain one or more active agents, alone or in combination, in one or more dosages and/or release pharmacokinetics. In an exemplary embodiment, the device has a cylindrical shape, having symmetrical wells on the outside of the device, each well containing one or more drugs, at one or more concentrations, sized to permit placement using a catheter, cannula, or stylet. Optionally, the device has a guidewire, and fiber optics, sensors and/or interactive features such as remote accessibility to provide for in situ retrieval of information and modification of device release properties. In a preferred embodiment, the fiber optics and/or sensors are individually accessible to discrete wells.

Abstract: Some embodiments provide a wearable fitness monitoring device including a motion sensor and a photoplethysmographic (PPG) sensor. The PPG sensor includes (i) a periodic light source, (ii) a photo detector, and (iii) circuitry determining a user's heart rate from an output of the photo detector. Some embodiments provide methods for operating a heart rate monitor of a wearable fitness monitoring device to measure one or more characteristics of a heartbeat waveform. Some embodiments provide methods for operating the wearable fitness monitoring device in a low power state when the device determines that the device is not worn by a user. Some embodiments provide methods for operating the wearable fitness monitoring device in a normal power state when the device determines that the device is worn by a user.

Abstract: A wearable device includes a detector configured to detect a response signal transmitted from a portion of subsurface vasculature, the response signal being related to binding of a clinically-relevant analyte to functionalized particles present in a lumen of the subsurface vasculature. Program instructions stored in a computer readable medium of the device, and executable by a processor, may cause the device to determine a concentration of the clinically-relevant analyte based on the response signal detected by the detector; determine whether a medical condition is indicated based on at least the concentration of the clinically-relevant analyte; and, in response to a determination that the medical condition is indicated, transmit data representative of the medical condition via the communication interface.

Abstract: A method for real-time, high-density physiological data collection includes automatically measuring, by a wearable device, one or more physiological parameters during each of a plurality of measurement periods, and upon conclusion of a measurement period, for each of the plurality of measurement periods, automatically transmitting by the wearable device data representative of the physiological parameters measured during that measurement period, to a server, the server configured to develop a baseline profile based on the data transmitted by the wearable device for the plurality of measurement periods. The measurement periods may extend through a plurality of consecutive days, and each of the consecutive days may include multiple measurement periods. At least some of the physiological parameters are measured by non-invasively detecting one or more analytes in blood circulating in subsurface vasculature proximate to the wearable device.

Abstract: A sensor system for sensing a stimulus in vivo includes an implantable sensor. The sensor comprises a passive resonator circuit having a resonant frequency and including at least a pair of generally parallel spirally wound unconnected conductive coils sandwiching a layer of solid dielectric material that manifest a change in property affecting the resonant frequency in response to application of the stimulus to the layer. A resonant frequency of the sensor is modulated by altering the spacing or gap between the coils or altering the overlapping area of the coils. The sensor is energized through application of radiofrequency energy and the responding resonant frequency is detected. The sensor can be advantageously attached to a medical implant to form a practical smart implant for clinical purposes.

Abstract: A system and method for detecting the amount or concentration of an analyte in a medium in living organism. The system may include an analyte sensor module and a transmitter module, which may be separate and distinct components. The analyte sensor module and transmitter module may be at different locations but connected by one or more transmission elements. The analyte sensor may include indicator elements configured to exhibit a detectable property based on the amount or concentration of the analyte in proximity to the indicator elements. The analyte sensor may include sensor elements configured to generate a data signal based on the detectable property exhibited by the indicator elements. The transmission elements may be configured to convey data signals generated by the sensor elements from the analyte sensor module to the transmitter module. The transmitter module may include an antenna.

Abstract: Methods, systems, and devices are described for providing risk evaluation and mitigation strategies for use with modified risk products or other tobacco products, and in particular, associated with nicotine and tobacco products.

Abstract: Systems and methods of use for continuous analyte measurement of a host's vascular system are provided. In some embodiments, a continuous glucose measurement system includes a vascular access device, a sensor and sensor electronics, the system being configured for insertion into communication with a host's circulatory system.

Abstract: Disclosed herein is an analyte sensing device capable of continuously monitoring metabolic levels of a plurality of analytes. The device comprises an external unit, which, for example, could be worn around the wrist like a wristwatch or could be incorporated into a cell phone or PDA device, and an implantable sensor platform that is suitable, for example, for implantation under the skin. The external device and the internal device are in wireless communication. In one embodiment, the external device and the internal device are operationally linked by a feedback system. In one embodiment, the internal device is encapsulated in a biocompatible coating capable of controlling the local tissue environment in order to prevent/minimize inflammation and fibrosis, promote neo-angiogenesis and wound healing and this facilitate device functionality.

Abstract: A device, system and method for detecting bile and blood are provided. The device may comprise a housing having a gap through which in-vivo fluids may flow, illumination sources on one side of the gap, a light detector which is facing the illumination sources and is positioned on the opposite side of the gap for detecting light which passes through the in-vivo fluids, and a transmitter to transmit the detected signals generated according to the detected light. The system may further comprise a receiver to receive the detected signals transmitted by the transmitter, and a processor. The method may comprise comparing the detected signals with a predetermined threshold calculated from the transmission spectra of bile and of blood and determining the presence and/or concentration of bile and blood in-vivo.

Abstract: A component for an arrangement at an implant includes a sensor detecting a measurement variable and generating measuring data corresponding to the detected measurement variable; telemetry device transmitting data; a data transmission connection between the sensor and the telemetry device for the transmission of the measuring data therebetween; and an assembly arrangement detachably mounting the component in an implant recess of the implant wherein the component is configured to be insertable through an implant recess of an implant positioned over a target portion of a bone so that the component extends through the opening toward an outer periphery of the target portion of the bone.

Abstract: Embodiments of the presently-disclosed subject matter include methods and systems for measuring a level of a neurotransmitter in a subject. Embodiments of the present methods comprise displaying a fixation point, a reward target, and a non-reward target, and measuring one or more saccade movement parameters for reward saccades and non-reward saccades. The saccade movement parameters can include velocity, amplitude, reaction time, or a combination thereof. The present methods can further include determining a reward modulation of the subject, the reward modulation being equal to a difference between the reward and the non-reward values for a respective saccade movement parameter. Some embodiments further include identifying the subject as including a deficiency of the neurotransmitter if there is a statistically measurable difference between the reward modulation of the subject and a reference reward modulation and/or if the non-reward and the reward saccade movement parameters are statistically equivalent.

Abstract: The invention relates to a detection device for the in vivo and/or in vitro enrichment of sample material, comprising a functional surface charged with detection receptors. To ensure the diagnosis of different diseases using a detection device of the type mentioned at the outset with less efforts and an improved precision of the diagnosis, it is provided according to the invention that the detection device comprises at least one guide element and at least two functional elements disposed at the guide element, wherein a functional surface charged with detection receptors is formed at each of them, the functional elements being designed for being detachable from each other and/or individually detachable from the guide element. Furthermore, the invention provides a use of and a method for the application of said detection device.

Abstract: Tissue-integrating electronic apparatuses, systems comprising such apparatuses and methods of using these apparatuses and systems for the detection of one or more signals are provided.

Abstract: A transceiver for interfacing with an analyte sensor. The transceiver may include an interface device and a notification device. The interface device may be configured to convey a power signal to the analyte sensor and to receive data signals from the analyte sensor. The notification device may be configured to generate one or more of a vibrational, aural, and visual signal based on one or more data signals received from the analyte sensor. The interface device of the transceiver may receive analyte data from the analyte sensor, and the transceiver may comprise a processor configured to calculate an analyte concentration value based on the received analyte data. The notification device may be configured to generate one or more of aural, visual, or vibrational alarm when the calculated analyte concentration value exceeds or falls below a threshold value.

Abstract: A method and communication system for ophthalmic device manufacturing line is disclosed. More specifically, the communication device may be incorporated in early stages of manufacturing of the ophthalmic device to monitor process controls without delay. In some embodiments, a unique pedigree profile can be stored for an ophthalmic device during manufacturing and correlated with one or more of: design profiles, controlled process parameters, performance, and distribution channels.

Abstract: The present invention described a system for an energized ophthalmic device with a media insert that includes microfluidic elements upon or within the media insert. In some embodiments, the microfluidic elements may be useful for the purpose of analyzing an analyte such as glucose in a fluid sample. In addition, some embodiments can function with a medicament administering device to treat an abnormal condition identified during the analyte analysis in the fluid sample.

Abstract: Sensor data obtained from a wearable sensor device can be correlated with sensor data obtained from a smart phone or other mobile device. The correlation of the data from the two sources can enable the determination of why a person performs some action during sleep. In a particular example, motion data obtained from a wearable sensor device can be correlated with audio or visual data obtained by a sensor on a smart phone. In this way, it can be determined whether a person moved in response to a sound or light perceived during sleep. Additionally, the correlation of the data from the two sources can also provide additional information about how a user performs an activity such as exercise.

Abstract: The disclosure relates to a device for performing diagnostics and/or therapy and related kit, system, computer program, methods and computer readable mediums. The device of this disclosure has the advantages that the device does not need access to the pericardium and that the whole system including kit and device can be removed after diagnostics/therapy. A device for performing diagnostics and/or therapy of an organ in the thoracic cavity, comprising an organ support (10), which organ support (10) is devised to be arranged exterior to an organ, and comprises: a flexible structure (14), such as a fabric, net, coil, bag or mesh, which is configured to cover a region of the organ, the region comprising at least the surface at an apex of the organ; at least one actuator (16), such as a motor, for actuating a movement of the flexible structure (14) for the therapy, and optionally at least one transducer (18), is provided.

Abstract: Disclosed are probes, systems, and devices that can be used to assay the presence of a biomarker in the sinus of a patient. The probes, systems, and devices can be used to contact the sinus fluid inside the sinus of a patient with an immunoassay for the presence of a biomarker that is characteristic of sinusitis. The probes can therefore be used to determine the underlying cause of sinusitis in a patient. Also provided are methods of treating sinusitis by administering to a patient a therapeutic regimen selected in view of a biomarker detected in the sinus of the patient. As the biomarker is associated with one or more causative agents of sinusitis, a therapy effective to treat the underlying causative agent can be selected.

Abstract: Apparatus for minimally invasively measuring concentrations of constituents contained within a biological tissue structure includes a microwave energy source arranged generate a range of microwave frequencies, a first antenna coupled to the microwave energy source and arranged to transmit at least a portion of the microwave energy into the tissue structure, a second antenna arranged to receive at least a portion of the microwave energy transmitted through the tissue structure, a signal processor arranged to determine the resonant frequency of the received microwave energy, and a data processor arranged to provide an output of the concentration of constituents within the biological tissue structure according to the determined resonant frequency.

Abstract: Carbon nanostructures may be protected and functionalized using a layer-by-layer method whereby functional groups on the carbon nanostructure surface may be further derivatized to incorporate additional functional moieties. Exemplary moieties include redox mediator molecules, crown ethers, catalysts, boric acids, carbohydrates, oligonucleotides, DNA or RNA aptamers, peptide aptamers, proteins such as enzymes and antibodies, quantum dots and nanoparticles, cells, cell organelles, or other cellular components. The density of functional groups or functional moieties on carbon nanostructure surfaces may also be controlled as well as the degree of surface hydrophilicity of the nanostructure.

Abstract: A method and system for monitoring a user's intoxication including receiving a set of signals, derived from a set of samples collected from the user at a set of time points; providing a sobriety task to the user proximal to a time point of the set of time points; generating a performance dataset characterizing performance of the sobriety task by the user; receiving a supplementary dataset characterizing a demographic profile of the user and/or a physiological state of the user; determining a set of values of an intoxication metric, derived from the set of signals; generating a predicted temporal profile of the intoxication metric for the user based upon the set of values, the set of time points, and the supplementary dataset; generating an analysis of the user's sobriety based upon the performance dataset and the predicted temporal profile; and providing a notification to the user based upon the analysis.

Abstract: A method for adjusting a sensor, continuous sensor or automatic measuring system in an interstitium including the steps of adjusting the steepness of a measuring curve and a standard offset (standard axis intercept) prior to the use of the sensor, continuous sensor or measuring system, and adapting the offset by a point calibration by using a reference measure or value during the use. The present invention encompasses sensors, continuous sensors or automatic measuring systems calibrated or adjusted in accordance with the method, and in some embodiments, the offset adjusted prior to use is rectified according to the difference between a value determined by the sensor, continuous sensor or measuring system taking into account the standard steepness and the reference value.

Abstract: Method and apparatus for channeling fluid away from an insertion site having a channel guiding the fluid flow from the insertion site, and a channeling compartment containing absorbent material to wick the fluid such as blood away from the insertion site is provided.

Abstract: A method, system and device for providing Point of Care Testing (POCT) are disclosed. The POCT comprises of a device that enables the patient to self conduct plurality of diagnostic tests for a chronic disease such as diabetes mellitus. The method is modular and enables the user to select set of tests from comprehensive list of diagnostic tests. The device provides a strip port to enable testing of various biochemical parameters. Also, the device comprises an ophthalmoscope with a built-in camera to capture images of the retina, a set of piezoelectric sensors for measuring pulse wave velocity (PWV), a pair of electrodes for measuring skin impedance. The method enables the device to log on the test data for future use and analysis. The device can be used for frequent monitoring of health parameters of a user suffering from diabetes mellitus.

Abstract: A needle system for penetrating to or passing thought an object or an organ comprising a semiconductor die, one or more needles, wherein the needles slide over the plane of the die, one or more actuators that move the needles relative to the die plane, and one or more actuator drivers controlled by a controller wherein the controller instruct the needle to penetrate into or to pass through and/or retract from the object or organ. The needle system is used for drug delivery or blood extraction or blood analysis or glucose measurements or blood measurements or nerve system stimulus treatment or hair removal or skin lesions removal.

Abstract: A bio-information acquiring terminal for acquiring bio-information includes a bath device (300). The bath device (300) is provided with a bio-information measuring unit (320) configured to measure bio-information of a user taking a bath, and a fingerprint authentication unit (303) configured to specify the user. According to the above configuration, it is possible to easily manage daily changes of the health condition of the user in his or her daily life.

Abstract: Diagnostic mouthpieces and separate pads for same allow dental devices of various types to have a dual purpose. The diagnostic mouthpieces allow frequent use and early intervention.

Abstract: Systems and methods for non-invasively determining parameters related to blood glucose are disclosed. Embodiments are disclosed wherein a wearable sensor device comprises non-invasive sensors generating various sensed data which is then utilized to determine a glucose-related parameter.

Abstract: An endocapsule has a measurement chamber therein containing a sensor that detects at least one metabolic product of a specific bacterium in a hollow organ of a human or animal gastrointestinal tract. The endocapsule is introduced into the hollow organ wherein detection of the at least one metabolic product takes place.

Abstract: A system of analysis with the naked eye and by fluorescence of a field in an illuminated area comprising a periodically-excited first low-remanence white light illumination source; a second light source for exciting fluorescent elements located in said field, active at least during part of the time periods when the first source is off; and a fluorescence analysis device active during time periods when the first source is off and the second source is on.

Abstract: A protective container for holding a reusable control part of a transcutaneous sensor system for detecting at least one analyte in a bodily fluid is disclosed. The control part includes at least one coupling, which has at least one sensor coupling for connection to at least one transcutaneous sensor. The protective container has at least one container housing. The control part can be held in the container housing. The container housing is adapted to shield the control part from environmental influences. The container housing also has at least one connector which can be connected to the coupling and seals the latter in a media-tight fashion.

Abstract: A method of predicting serum phosphorus concentrations in a patient during hemodialysis includes measuring serum phosphorus concentrations of the patient over a hemodialysis treatment session time and an ultrafiltration rate calculated by a difference between pre- and post-dialytic body weight of the patient during an initial hemodialysis treatment session divided by a total treatment time of the treatment session and estimating a phosphorous mobilization clearance and a pre-dialysis distribution volume of phosphorus for the patient. Serum phosphorus concentrations of the patient can then be predicted at any time during any hemodialysis treatment session with the estimated phosphorous mobilization clearance and pre-dialysis distribution volume of phosphorus of the patient.

Abstract: There are provided a diagnostic module for diagnosing a disease and a disease diagnosis apparatus including the same. The disease diagnosis apparatus includes a patch including one or more diagnostic module attachable-detachable recesses, one or more diagnostic modules detachably attached to the diagnostic module attachable-detachable recesses to collect and analyze blood, and a processor processing analysis results.

Abstract: A pulse rate sensor that includes an accelerometer for measuring periodic motion and a piezo sensor for detecting erratic motion is capable of more accurately determining pulse rate by accounting for these types of motion. The pulse rate sensor in accordance with the present invention diminishes pulse rate signal degradation due to erratic motion through a combination of algorithms that control signal boosting, waveform refinement and signal noise suppression.

Abstract: Systems and methods are provided for performing a medical procedure within a patient's body that involves a thoracic duct including an ostium communicating with the patient's venous system. A distal end of a catheter is introduced through the patient's venous system into a body lumen adjacent the ostium of the thoracic duct. An expandable member on the distal end of the tubular member may be expanded adjacent the ostium, e.g., within the body lumen or the thoracic duct itself, and used to isolate the thoracic duct from the body lumen, whereupon a medical procedure may be performed via the thoracic duct. For example, lymphatic fluid may be removed from the thoracic duct through a lumen of the tubular member and/or one or more agents may be introduced into the thoracic duct through the tubular member.

Abstract: A device for applying a sensor to a measurement site on a patient's skin has a wall arrangement defining an applicator volume above the patient's skin The wall arrangement has a patient's side and a sensor side. At least one gas-permeable membrane separates the applicator volume into a first volume directed to the measuring site at the patient's side of the wall arrangement and a second volume separated from the patient's skin and directed to the sensor side of the wall arrangement.

Abstract: Devices and methods for positioning a portion of a sensor at a first predetermined location, displacing the portion of the sensor from the first predetermined location to a second predetermined location, and detecting one or signals associated with an analyte level of a patient at the second predetermined location are disclosed. Also provided are systems and kits for use in analyte monitoring.

Abstract: Breast implants including sensor modules and related methods are described herein. Breast implants include those with: a shell configured to be substantially filled with a viscous material; at least one fluid-permeable cover, the cover completely enveloping the shell; and a plurality of sensor modules attached to the shell and positioned at a distance from each other, each of the sensor modules oriented to detect one or more analytes in a fluid between the shell and the cover, wherein each of the plurality of sensor modules includes a unique identifier and is configured to utilize energy transmitted from an external source.

Abstract: Breast implants including sensor modules and related methods are described herein. Breast implants include those with: a shell configured to be substantially filled with a viscous material; a plurality of projections extending from an external surface of the shell, the projections forming a plurality of compartments adjacent to the external surface of the shell; at least one fluid-permeable cover attached to the projections, the cover completely enveloping the shell and the plurality of projections; a plurality of sensor modules attached to the shell, each of the sensor modules oriented to detect one or more analytes in a fluid within one of the plurality of compartments, wherein each of the plurality of sensor modules includes a unique identifier; and at least one power source operably attached to the plurality of sensor modules.

Abstract: The invention relates to a capsule or chip or sensor comprising a marker/detector and signalling device/method associated with the development of a medical condition/disease and to its use. This In Situ Lab On a Chip Signalling device (ISLOGS device) is used for detecting a medical condition/disease in situ or in vivo (inside the body), for example by swallowing it for testing in the digestive tract or by putting it into the vagina, mouth or nose. All reactions takes place in the body and when the test result is positive the device will notify the subject by colorizing the tested body fluid or biomaterial (for example faeces, urine or saliva) or the device itself. The detection is made outside of the body when the biomaterial or ISLOCS device has left the body.

Abstract: The present invention relates to a method and composition for the aspiration, processing, testing and infusion of bone marrow derived stem cells, as an adjuvant treatment in cardiovascular disorders. More specifically, the invention provides for the methods and compositions for the aspiration, analysis, processing, infusate preparation and infusion of bone-marrow derived stem cells, particularly in a rapid point-of-care environment, wherein a centrifugal fractionation and optically monitored separation of the bone marrow yield desired cellular product in the desired concentration and viscosity.

Abstract: The present invention relates to a method and composition for the aspiration, processing, testing and infusion of bone marrow derived stem cells, as an adjuvant treatment in cardiovascular disorders. More specifically, the invention provides for the methods and compositions for the aspiration, analysis, processing, infusate preparation and infusion of bone-marrow derived stem cells, particularly in a rapid point-of-care environment, wherein a centrifugal fractionation and optically monitored separation of the bone marrow yield desired cellular product in the desired concentration and viscosity.

Abstract: In alternative embodiments, the invention provides compositions such as devices, pills, beads, capsules, products of manufacture, particles, microparticles, nanoparticles, gels, liquid gels, liquid gel capsules, capsules, tablets, geltabs, liquids, sprays, emulsions, suspensions, pastes or yogurts, for the detection and isolation of biomarkers, nucleic acids, proteins or peptides, proteoglycans, lipids, fats, sugars or polysaccharides in the gastrointestinal tract for e.g., detecting the presence of particular exogenous or endogenous nucleic acids, e.g., DNA or RNA, or proteins, in the gastrointestinal tract, for example, to diagnose the presence of an infectious or exogenous agent such as a virus, a fungus, a parasite, a bacteria, intestinal helminths and protozoan parasites, and the like, or a biomarker such as a cancer-causing or cancer-predisposing allele, e.g., mutations of the KRAS2 oncogene in pancreatic cancer.

Abstract: A medical apparatus for supplying a medication fluid into an organism and for detecting a substance of the organism is disclosed. The medical apparatus has a casing, cannula, and an insertion needle. The casing has a chamber accommodating the medication fluid and an opening in fluid communication with the chamber. The cannula has a lumen in fluid communication with the chamber. The insertion needle has a receptacle. A portion of the insertion needle is removably arrangeable with the lumen. The receptacle is configured to at least partially receive a sensor system for detecting the substance of the organism. A seal is adapted to annularly sealingly surround a portion of the sensor system when the insertion needle is removed from the opening and the portion of the sensor system is arranged in the opening.

Abstract: Surface selective photoacoustic (PA) medical imaging is introduced. Surface selective PA imaging is responsive to surface features and does not image sub-surface features, in contrast to conventional PA imaging. The surface PA signal can be considerably larger than the bulk PA signal, for an air-coupled (or gas-coupled) acoustic transducer. Distinguishing these two signals based on time of arrival at the transducer can further distinguish the two signals. This approach provides numerous advantages. Non-contact imaging simplifies and expedites imaging, and can serve as a replacement for visual inspection by physicians. Applications include skin screening and endoscopy.

Abstract: Disclosed in an individual information determining method in which individual information of a subject is determined based on one or a plurality of pieces of biomolecule data collected from a surface of a body surface of the subject.

Abstract: The present invention provides a biointerface membrane for use with an implantable device that interferes with the formation of a barrier cell layer including; a first domain distal to the implantable device wherein the first domain supports tissue attachment and interferes with barrier cell layer formation and a second domain proximal to the implantable device wherein the second domain is resistant to cellular attachment and is impermeable to cells. In addition, the present invention provides sensors including the biointerface membrane, implantable devices including these sensors or biointerface membranes, and methods of monitoring glucose levels in a host utilizing the analyte detection implantable device of the invention. Other implantable devices which include the biointerface membrane of the present invention, such as devices for cell transplantation, drug delivery devices, and electrical signal delivery or measuring devices are also provided.