Abstract: A valerian composition includes a therapeutically effective pharmaceutical dosage form having a solid core including a polymer in which valerian and a valerian stability improving amount of an acidifying agent are contained. The valerian stability improving amount of acidifying agent being sufficient to impart a pH of 2 to 5 to the polymer.

Abstract: A pharmaceutical composition for ischemia treatment of a patient includes a ginkgo extraction and a pharmaceutically acceptable carrier. The dosage form of the pharmaceutical composition is gel, transdermal patch, cream or paste. The patient is a neonate, an infant, or an early child. A use of the pharmaceutical composition for ischemia treatment of a patient is disclosed.

Abstract: The invention relates to a tablet or capsule containing a plant extract, to assist in the treatment or prevention of disorders or diseases. The tablet or capsule includes bioconverted products provided by fermenting Withania Somnifera extract, Emblica officinalis extract, and Bacopa monnieri extract.

Abstract: The present disclosure provides mixtures of prenylated flavonoids, stilbenes, or both with flavans or curcuminoids or both capable of modulating joint inflammation, joint pain, joint stiffness, cartilage degradation, or improving mobility, range of motion, flexibility, joint physical function, or any combination thereof. Such a mixture of prenylated flavonoids, stilbenes, or both with flavans or curcuminoids or both can optionally be used in combination with other joint management agents, such as non-steroidal anti-inflammatory agents/analgesics, COX/LOX inhibiting agents, glucosamine compounds, neuropathic pain relief agents, or the like.

Abstract: The present disclosure discloses a herbal formulation in powdered dosage form, which is useful to enhance the physical endurance or strength in athletes. The disclosure also includes a method of preparation of the formulation, which involves the encapsulation of the natural ingredients in a natural matrix. The formulation comprises Moringa oleifera, Kaempferia parviflora and Punica granatum that are processed to obtain the product in powder form by encapsulation of the natural ingredients in a natural matrix. The formulation increased the nitrate and nitrite levels in serum and saliva in human and is useful to improve the general health of the athletes.

Abstract: Provided herein is a topical analgesic composition that includes an external analgesic agent, one or more pharmaceutically acceptable excipients, and at least one of a cannabinoid, terpene, and flavonoid. Also provided is a method that includes topically administering to a skin surface of a subject (e.g., human) the topical analgesic composition.

Abstract: The present disclosure discloses a method for preparing a citrus-derived complex prebiotic agent. The method comprises the following steps: removing external citrus peels after blanching citrus fruits with hot water, soaking citrus segments after splitting with an acid solution and an alkali solution to remove membranes of the citrus segments, and adjusting the pH of the obtained alkali soaking water with acid soaking water or acid to be weakly acidic or neutral to obtain the complex prebiotic agent, which has the function of reversing intestinal flora disorders. Compared with the traditional prebiotic product preparing method, the product prepared by the method contains prebiotic functional components with different targets such as pectin, flavonoids, oligosaccharides, and other fibers at the same time, and has the efficacies of regulating intestinal flora and reversing intestinal flora disorders caused by antibiotics.

Abstract: Disclosed is a therapeutic regimen which includes S-adenosyl methionine, or a salt thereof; folic acid, or a metabolite therof, or a salt thereof; and a compound of Formula (I), or salt thereof, useful in the treatment of a variety of conditions, e.g., neuropsychiatric conditions such as depression. The therapeutic regimen may be used in combination with therapeutic agents as described here.

Abstract: The invention relates to methods of producing extracts from cannabis plant material, where the extracts comprise cannabinoids and terpenes. The methods comprise extracting fresh or dried plant material with a cold organic solvent. The methods allow for the extraction of cannabinoids and terpenes, while leaving behind impurities such as waxes and chlorophyll that are commonly found in extractions with room temperature (RT) or warm solvent extraction methods. The methods can produce extracts having more than 90% cannabinoids.

Abstract: A method for producing a medicinal food product includes the steps of homogenously mixing a first non-medicinal food base with at least one medicinal product to prepare a medicinal-infused food-based carrier, adding the carrier to a second food base to prepare a medicinal-infused food item, freezing, dehydrating and dividing the food item, placing the divided items in flexible containers, and vacuum sealing the containers for prolonged storage. Preferably, the medicinal product is a cannabinoids, such as cannabis, THC, CBD, CBN or CBG.

Abstract: A rodenticide composition is described along with a method for using the same to exterminate rodents. The composition features a mixture of a dehydrant for causing dehydration in a rodent, a water-absorbent, hygromorphic carrier for absorbing water and expanding after consumption by the rodent, and a flavoring composition. The carrier can be a source of cellulose or a non-cellulosic material. After consumption of the composition by a rodent, the dehydrant and carrier cause the rodent to experience dehydration. The rodenticide composition may also include an irritant that causes digestive stress to the rodent, which further stresses and dehydrates the rodent. Once the rodenticide composition is prepared, it may be placed in areas frequented by or infested with rodents so as to kill the rodents once they consume the composition. One or more flavorings, coloring agents, and weather resistant materials may also be added to the composition.

Abstract: A method of treating an activated fibroblast associated disease or pre-disease condition in a mammal comprising, administering a pharmaceutical composition including a therapeutically effective amount of a first therapeutic, wherein the first therapeutic is one of an intracellular Ca2+ elevator, a YAP/TAZ inhibitor, both a intracellular Ca2+ elevator and a YAP/TAZ inhibitor, or pharmacologically acceptable salts, solvates, esters, amides, clathrates, stereoisomers, enantiomers, prodrugs or analogs thereof, or a combination thereof.

Abstract: A method for producing a terpene-enhanced cannabinoid concentrate and for removing contaminants such as pesticides and fungicides from cannabinoid extracts. Cannabinoid extracts containing contaminants may be dissolved in a water and ethanol solution, and then cooled to allow water-soluble contaminants to settle out of the mixture. The water and ethanol may then be removed via evaporation or distillation, leaving purified cannabinoids without contaminants. Contaminant removal may be incorporated into a method for producing a blended extract of cannabinoids and terpenes, which extracts terpenes using supercritical CO2, and extracts a cannabinoid concentrate from the residual material using a cold ethanol flush followed by distillation and then by contaminant removal; the CO2-extracted terpenes are then added back to the purified cannabinoid concentrate in a final blending step. Blending terpenes at the end of extraction may enhance the flavor and effectiveness of the purified cannabinoid concentrate.

Abstract: A system for decarboxylating and infusing an organic material includes a decarboxylation and infusion apparatus is provided. The apparatus includes a heated reservoir in operable communication with a user interface whereon a user selects decarboxylation and infusion settings. The heated reservoir has a mixing element to agitate an organic material and solvent disposed therein as well as a filter to filter the organic material following the infusion.

Abstract: A solvent-free method to extract THCA from cannabis, said method comprising: providing a source of THCA-containing cannabis plant; providing a source of natural oil; combining said source of THCA-containing cannabis and said source of natural oil into a blend; milling said blend; optionally, heating the blend during the milling; and extracting a THCA-containing liquid generated during the milling.

Abstract: The present invention relates generally to methods of use and compositions useful for treating skin. The composition includes a combination of Phoenix dactylifera extract, tea tree oil, Myrothamnus flabellifolia extract, and saccharide isomerate. This combination can be used to create topical skin compositions that reduce rosacea, erythema, and/or inflammation, and inhibit nitric oxide synthase, increase ?2A adrenergic receptor agonist activity, reduce oxidation, increase anti-oxidant capacity of a composition or of skin, inhibit cyclooxygenase-2 (COX-2) production, inhibit vascular endothelial growth factor (VEGF) production, inhibit interleukin-6 (IL-6) and interleukin-8 (IL-8) production, reduce tumor necrosis factor alpha (TNF-?) production, increase collagen stimulation, increase lysyl oxidase expression, inhibit matrix metalloproteinase 1 (MMP1) activity, increase occludin production, increase filaggrin production, and increase skin moisturization.

Abstract: The present invention provides a process for obtaining an extract from White Truffle (Tuber magnatum) for skin cosmetic use, the white truffle extract obtainable by the process and a cosmetic composition comprising the said extract. The invention provides a method for reducing the signs of aging and lightening the skin.

Abstract: A method of increasing the cannabinoid levels in a genetically modified Cannabis sativa plant includes genetically modifying the plant to induce the overexpression of the gene that controls the expression of tetrahydrocannabinolic acid (THCA) synthase and/or cannabidiolic acid (CBDA) synthase. The overexpression of THCA synthase and CBDA synthase catalyzes an increased synthesis of cannabigerolic acid to tetrahydrocannabinolic acid and cannabidiolic acid, as well as the cannabinoids (3aR)-2,4,4-trimethyl-7-pentyl-3,3a,4,9b-tetrahydrocyclopenta[c]chromen-9-ol and 2-((1R,5R)-3-methyl-5-(prop-1-en-2-yl)cyclopent-2-en-1-yl)-5-pentylbenzene-1,3-diol. Pharmaceutical compositions comprising the modified cannabinoids produced by the transgenic Cannabis sativa plant or prepared synthetically are used to treat various diseases and conditions.

Abstract: Beneficial topical compositions for treating scar or aging skin are provided. In one embodiment, the compositions include Bulbine frutescens, Centella asiatica and a phenol derived from olives, such as oleuropein. The composition may be used in the treatment of scars formed during surgery. The composition may also be used cosmeceutically in the treatment of aged skin, and may include phosphatidylserine, vitamins, and other beneficial anti-aging ingredients.

Abstract: Oral compositions provide delivery of cannabinoids to a subject. The oral compare chewable, fast- or slow-dissolving once placed in the mouth of a subject.

Abstract: The invention relates to skin care compositions comprising an ethanol extract obtained from the leaves and/or stems of Arthrocnemum macrostachyum and/or Tetraena sp. cf. mandavillei. In addition, the invention relates to methods for treating a skin condition, reducing the risk of developing a skin condition, for treating wounds, for reducing and/or delaying the effects of aging of skin, and/or for treating and/or reducing inflammation of skin by administration of skin care compositions of the invention.

Abstract: The present invention relates to synergistic compositions comprising extracts or fractions derived from Bacopa monnieri in combination with extracts or fractions derived from Terminalia chebula for improving brain health, memory/mental condition, enhancing brain/mental functions such as cognition, memory, learning, retention, communication and for treating neurodegenerative diseases/disorders such as Alzheimer's disease, Parkinson's disease etc. The invention further relates to method of improving brain health and brain functions selected from cognition, memory, memory retention, information recall, intelligence, motivation, attention, concentration, learning power and communication and to alleviate disease conditions related to cognition and memory deficits in a mammal by supplementing the mammal with an effective dose of the synergistic composition comprising at least one extract or fraction derived from Bacopa monnieri in combination with at least extract or fraction derived from Terminalia chebula.

Abstract: The invention discloses synergistic compositions comprising at least one component selected from extract(s) and fraction(s) or mixtures thereof derived from Sphaeranthus indicus in combination with at least one component selected from extract(s), fraction(s), active compound(s) or mixtures thereof derived from Terminalia chebula for improving the liver health. The invention further discloses method of improving the liver health in humans and animals by administering the compositions comprising at least one component selected from extract(s) and fraction(s) or mixtures thereof derived from Sphaeranthus indicus in combination with at least one component selected from extract(s), fraction(s), active compound(s) or mixtures thereof derived from Terminalia chebula.

Abstract: Use of an olive oil milling by-product (Alperujo or Olive Pomace) for the co-processing and co-extraction of natural compounds from medicinal and aromatic plants, fruits and agricultural waste, algae and other microorganisms. Separation and stabilization of fractions containing either hydrophilic or liposoluble compounds. The plants may include Cannabis.

Abstract: A dermal skin protectant and carrier comprising a combination of two different viscosity dimethicone components, wherein the difference between the two different viscosity dimethicone components is about 2.0 million cP or greater; and comprising at least one active ingredient.

Abstract: The present invention is concerned with a composition for repairing human skin. Specifically, the composition has a DNA repair enzyme and at least one phycobiliprotein. The DNA repair enzyme is a photolyase, and the photolyase and/or the phycobiliprotein is encapsulated by liposomes. The composition is effective in repairing damage to human skin as a result of environment daily stress, sun exposure, or premature-aging.

Abstract: Natural products were screened for their insect repellent activity, and carrot seed essential oil gave very high activity in biting repellent/deterrent bioassays. Analysis of the oil revealed the presence of 47 compounds, mainly mono- and sesqui-terpenes. The sesquiterpene, carotol, constituted more than 75% w/w of the oil. In the initial screening, the essential oil gave high biting deterrent activity and high repellent activity comparable to DEET against both Aedes aegypti and Anophies quadrimaculatus species of mosquitoes. The active fraction mainly comprises pure carotol. The essential oil and the pure compound have a potential to be developed and used as effective repellent against mosquitoes.

Abstract: Disclosed are a traditional Chinese medicine composition for treating tumours and a preparation method therefor, wherein the composition is prepared from Sophora flavescens, wild Chrysanthemum flower, honeysuckle, mint, Poria cocos, Atractylodes lancea, cinnamon, clove, Astragalus, Ganoderma lucidum, Ligusticum striatum, Aucklandia root and Radix glycyrrhizae. The traditional Chinese medicine composition has an anti-tumour effect.

Abstract: This invention relates to a pharmaceutical preparation for the treatment of compromised tissue such as skin wounds and ulcers in humans and animals and a method of preparation. This is a multifunctional natural matrix meant for the treatment of compromised tissues which also relates to the anti-cancer transdermal patch for melanoma therapy. Further, the invention comprises for the treatment of Alzheimer's, and multiple sclerosis also. The composition consists of water-solubilized nano-sized formulation of non-aqueous solvent extract of phytopharmaceuticals in herbal, animal or synthetic biocompatible gel or on matrix coated or both. The composition is used as a topical device for the treatment of compromised tissues in its preferred embodiment.

Abstract: This patent application describes a film developed from natural compounds to cover wounds, whose method of application is in the form of individual disposable packages, vials, syringes and/or others. This wound dressing provides a moist environment at the wound site allowing the occurrence of the autolytic debridement. The film incorporates bioactive agents such as acetylsalicylic acid, essential oils, plant extracts and others, which confer antibacterial, antifungal, anti-inflammatory, antioxidant and regenerative properties. The application method is also explored in order to simplify the life of patients, and to minimise pain and discomfort felt by them, during primary care treatment.

Abstract: Provided is a cosmetic composition for skin moisturization containing a hydrolyzate extract obtained by adding a protease to the fruit of Cicer arietinum, a Rhododendron chrysanthum leaf extract and a Tricholoma matsutake extract. The cosmetic composition exhibits excellent effects on cell moisturization, intercellular moisturization and skin-barrier moisturization. In addition, the cosmetic composition is harmless to the human body and has excellent stability because it uses natural substances.

Abstract: The present invention provides ophthalmic compositions, e.g. artificial tears, suitable for treating dry eye syndrome in a human or other mammal suffering there from, e.g. a dog or cat, which comprise a mixture of castor oil with another oil, e.g. a food oil, e.g. olive oil, sesame oil, corn oil etc.

Abstract: A method of modulating body weight using a composition of rosemary extract having a pre-determined amount of ursolic acid.

Abstract: The present invention discloses a composition comprising Nigella sativa extract standardized to contain not less than 0.1% w/w thymoquinone and not less than 0.01% w/w thymohydroquinone, Coleus forskolii extract standardized to contain not less than 90% w/w forskolin and Piper nigrum extract standardized to contain not less than 95% w/w piperine extract for use in enhancing melanogenesis in mammalian cells. The invention also discloses the use of above mentioned composition in the therapeutic management of hypomelanotic skin conditions and in reducing the progression of depigmentation of skin in vitiligo in mammalian skin.

Abstract: Described herein are methods of preparing cutin-derived monomers, oligomers, or combinations thereof from cutin-containing plant matter. The methods can include heating the cutin-derived plant matter in a solvent at elevated temperature and pressure. In some preferred embodiments, the methods can be carried out without the use of additional acidic or basic species.

Abstract: Functional beverage compositions in liquid form. The functional beverage compositions include water, lecithin, a punicic acid-containing oil, and a cannabinoid-containing oil. The punicic acid-containing oil and the cannabinoid-containing oil are stably suspended within the water. Methods of using the compositions include administering the compositions to reduce inflammation in a subject or treat an inflammation-related disease in a subject. Methods of making the compositions include suspending the punicic acid-containing oil and the cannabinoid-containing oil in a sub-volume of water and adding additional water to arrive at a final composition volume.

Abstract: A toothpaste product that is laced with, or infused with, a sedative such as the active ingredients in cannabis. The act of brushing one's teeth using the present invention transfers the sedative into the bloodstream through contact with the gums, leading to a more restful sleep.

Abstract: An improved process for producing refined oils free of contaminating waxes, resins, and lipids from botanical plant matter using an improved in-line winterization process is disclosed. The biomass is fed into an extraction vessel where the oils are extracted using a solvent, followed by a two-stage separation. Both the temperature and pressure of the solvent going into the separators are controlled for effective separation. Additional solvent is added to enhance the separation efficiency between the refined oil and the undesired fraction containing the contaminants. This process provides an alternative to current wax mitigation techniques, such as alcohol based solvent winterization.

Abstract: A concentrated lipid-based solution including tetrahydrocannabinol (THC) is manufactured by providing a lipid solution including an array of triglycerides, cannabinoids and water soluble contaminants in a pressure vessel. Water is added to the lipid solution to create a mixture and the pressure is increased in a first phase at a first pressure and duration and in a second phase at a second temperature and duration. The mixture is agitated to dissolve the water soluble contaminants. The mixture is cooled to cause the triglycerides and cannabinoids to solidify. The solidified triglycerides and cannabinoids, including THC, are separated to yield a purified cannabinoid solution.

Abstract: The invention refers to a method for obtaining polyhydroxy 1,4-naphthoquinones from live sea urchins, comprising the following steps: a) injecting a KCl saline solution into the perivisceral coeloma of female sea urchins to induce spawning; b) collecting the eggs, and grinding them into a fine powder; c) mixing said fine powder with an alcoholic solvent; d) separating the alcohol supernatant comprising the polyhydroxy 1,4-naphthoquinones in solution. Where the polyhydroxy 1,4-naphthoquinones are selected from: echinochrome A (6-ethyl-2,3,5,7,8-pentahydroxy-1,4-naphthoquinone), spinochrome A (2-acetyl-3,5,6,8-tetrahydroxy-1,4-naphthoquinone), spinochrome B (2,3,5,7-tetrahydroxy-1,4-naphthoquinone), spinochrome C (2-acetyl-3,5,6,7,8-pentahydroxy-1,4-naphthoquinone), spinochrome D (2,3,5,6,8-pentahydroxy-1,4-naphthoquinone), spinochrome E (hexahydroxy-1,4-naphthoquinone) or mixtures thereof.

Abstract: A method for post processing oil extracted from cannabis comprises the steps of placing the oil into a pressure rated vessel, adding a first predetermined quantity of liquid Butane, sealing the pressure rated vessel shut, and heating the pressure rated vessel to a first predetermined temperature for a first predetermined time. The steps further comprise cooling the pressure rated vessel, releasing pressure from the pressure rated vessel, transferring the oil from the pressure rated vessel to another container, and vacuum oven purging the oil under a first predetermined level of vacuum at a second predetermined temperature for a second predetermined period of time.

Abstract: The present invention discloses a composition for improving internal circulation and delaying aging and application thereof, and the composition is prepared by Rosa roxburghii, Phyllanthus emblica, honey, walnut and Citrus limon as raw materials.

Abstract: When a catechin-free tea water according to the present invention is contained in a cosmetic or pharmaceutical composition, enzymes are inactivated and catechin contained in tea leaves is removed by steaming unprocessed raw tea leaves, thereby preventing the oxidation of tea water. Therefore, a composition containing the tea water according to the present invention can prevent offensive odor generation or discoloration of the composition, thereby enabling the stable use thereof in various industrial fields such as food, cosmetics and medicine. In addition, plenty of skin helpful ingredients, contained in raw tea leaves, can be contained, and thus excellent skin barrier function recovery or skin moisturization effects can be provided.

Abstract: The present disclosure relates to a herbal compound extract to moderate diabetes with liver necrosis and fibrosis and applications thereof wherein a herbal compound consists of 10 to 20 units rhizome of Dendrobium nobile Lindl, 6 to 12 units fruiting body of Antrodia camphorata, 12 to 20 units root of Panax ginseng C. A. Mey, 10 to 30 units root of Rehmannia glutinosa Libosch, 15 to 30 units rhizome of Salvia miltiorrhiza Bge., 6 to 12 units all of Pheretima asperfillm (E. Perrier), 10 to 30 units root of Pueraria mirifica, 8 to 15 units fruit of Schisandra chinensis (Turcz.) Baill and 6 to 8 units rhizome of Glycyrrhiza uralensis Fisch and the herbal compound extract is able to moderate symptoms comprising hyperglycemia, hyperlipidemia, abnormal liver function about liver necrosis and fibrosis due to the diabetes.

Abstract: A method of minimizing fat accumulation in a growing animal without limiting caloric intake or preventing or treating obesity in an animal, the method comprising orally administering a ketogenic diet and a nutrient blend to the animal. The nutrient blend can include at least four nutrients selected from the group consisting of walnut, maitake mushroom extract, EGCG, turmeric root powder, lycopene, taurine, EPA, and DHA to the animal.

Abstract: The invention relates to the preparation of a water soluble, powdered pharmaceutically active cannabinoid and/or terpene extract from plant materials, a powder where the bulk density can easily be modified depending on the final dosage form required. The extract is first treated with a solvent to solubilize the cannabinoids, then combined with an emulsifier. The solubilized mixture is then dried to evaporate the solvent, leaving the water-soluble cannabinoid extract powder. The resulting powder remaining stable at room temperature for at least one year and can be compounded into various pharmaceutical powdered formulations, with varying bulk powder densities.

Abstract: The present invention relates to a foodstuff comprising feather hydrolysate for use in improving performance during exercise and/or improving recovery after exercise in a dog. It also relates to a method of improving the performance in a dog during exercise and/or improving recovery after exercise, the method comprising administering to a dog a foodstuff which comprises feather hydrolysate.

Abstract: The present invention relates to the use of coconut water as extraction solvent, to extraction methods using coconut water and extracts obtained by extraction with coconut water.

Abstract: A method of treating a triterpene-responsive condition, disease or disorder in a subject by administration of an improved triterpene-based composition is provided. An improved triterpene-based composition comprising at least two or at least three triterpenes present at a molar ratio as described herein is also provided.

Abstract: The present invention provides a soybean based non-toxic, non-hazardous, user and environmentally friendly odor trapping composition matter as a toilet spray. This product not only limits the undesired smell from defecation and releases a desirable smell, but also has potential antimicrobial properties to sanitize the toilet bowl.