Nitriles (i.e., Compounds Having Cyano Bonded Directly To Carbon, Which Carbon May Be Single Bonded To Any Atom But May Be Multiple Bonded Only To Carbon) Patents (Class 558/303)
  • Patent number: 6242654
    Abstract: A preparation process of a fluorine substituted aromatic compound comprising reacting an alkali metal or alkali earth metal salt of an aromatic compound having a hydroxy group with an organic fluorinating agent is disclosed. As a representative fluorinating agent, a bis-dialkylamino-difluoromethane compound, for example, 2,2′-difluoro-1,3-dimethylimidazolidine, is exemplified. According to the process, an industrially useful fluorinated aromatic compound, for example, a fluorobenzene, a fluorine substituted benzophenone, a fluorine substituted diarylsulfone can be prepared with ease in economy without specific equipment.
    Type: Grant
    Filed: December 21, 1999
    Date of Patent: June 5, 2001
    Assignee: Mitsui Chemicals, Inc.
    Inventors: Kenichi Goto, Kouki Fukumura, Hiroshi Sonoda, Junko Naruse, Hidetoshi Hayashi, Hideaki Oikawa
  • Patent number: 6197825
    Abstract: The present invention relates to chromotropic nitrone spin trapping agents, methods of making these agents, compositions comprising same, and methods of their use. In particular, azulenyl nitrones of the present invention are effective agents for trapping free radical species and find use as efficient antioxidants in physicochemical and biological systems. Accordingly, the invention also relates to spin adducts formed from the combination of azulenyl nitrones with free radicals. The compounds of the present invention are readily prepared from available starting materials and find further use in assays and in a number of diagnostic, prophylactic and therapeutic applications, including but not limited to the alleviation, modulation and inhibition of the negative effects of carbon-centered or oxygen-centered radical species and other products of oxidation. Moreover, the combination adducts may be calorimetrically detected and, optionally, isolated and characterized to obtain valuable information (e.g.
    Type: Grant
    Filed: May 28, 1998
    Date of Patent: March 6, 2001
    Assignee: Florida International University
    Inventor: David Alan Becker
  • Patent number: 6132985
    Abstract: The present invention describes methods for the detoxification of a mixture of nitrile compounds, or a mixture of nitrile and amide compounds by conversion of the nitrile compound(s) to the corresponding amide or acid compounds using a pure culture of an induced microorganism strain capable of converting a nitrile moiety to an amide or acid moiety. If an amide is formed or is present in the mixture, the amide can be further converted, using the present methods for detoxification, to the corresponding acid. The acid can then, if desired, be further degraded to CO.sub.2, H.sub.2 O and biomass. The induced pure cultures are able to detoxify a mixture of nitriles or a mixture of nitrites and amides which are typically present, in high concentration(s), in nitrile production waste streams.
    Type: Grant
    Filed: June 18, 1999
    Date of Patent: October 17, 2000
    Assignee: Cytec Technology Corporation
    Inventor: George E. Pierce
  • Patent number: 6120557
    Abstract: Use of compounds of the formula ##STR1## where the radicals R.sup.1, R.sup.2 and A are as defined in the description, as bleach activators in bleaching detergents and cleaners.
    Type: Grant
    Filed: October 6, 1999
    Date of Patent: September 19, 2000
    Assignee: Clariant GmbH
    Inventor: Bernd Nestler
  • Patent number: 6096778
    Abstract: This invention relates to .alpha.-ketoamide inhibitors of multicatalytic protease (MCP), to compositions including such inhibitors, and to methods for the use of MCP inhibitors. The MCP inhibitors of the present invention are useful, for example, to retard loss of muscle mass incident to various physiological states.
    Type: Grant
    Filed: October 6, 1998
    Date of Patent: August 1, 2000
    Assignee: Cephalon, Inc.
    Inventors: Sankar Chatterjee, John P. Mallamo
  • Patent number: 6096848
    Abstract: Biscyanoacrylates in solution are prepared by reacting 2-cyanoacrylic acids or their alkyl esters with diols in the presence of sulfonic acids as catalysts. The reaction mixture is processed by substituting an aliphatic solvent for the aromatic solvent and is then subjected twice to fractional crystallization. The thus obtained biscyanoacrylates are very pure. They are therefore useful for producing storage stable cyanoacrylate adhesives. Their admixture increases the thermal resistance of the adhesives, which is particularly important in the case of electric and electronic components.
    Type: Grant
    Filed: March 5, 1997
    Date of Patent: August 1, 2000
    Assignee: Henkel Kommanditgesellschaft auf Aktien
    Inventors: Yuri Gololobov, Werner Gruber, Christian Nicolaisen
  • Patent number: 6060265
    Abstract: The present invention describes methods for the detoxification of a mixture of nitrile compounds, or a mixture of nitrile and amide compounds by conversion of the nitrile compound(s) to the corresponding amide or acid compounds using a pure culture of an induced microorganism strain capable of converting a nitrile moiety to an amide or acid moiety. If an amide is formed or is present in the mixture, the amide can be further converted, using the present methods for detoxification, to the corresponding acid. The acid can then, if desired, be further degraded to CO.sub.2, H.sub.2 O and biomass. The induced pure cultures are able to detoxify a mixture of nitriles or a mixture of nitriles and amides which are typically present, in high concentration(s), in nitrile production waste streams.
    Type: Grant
    Filed: June 25, 1998
    Date of Patent: May 9, 2000
    Assignee: Cytec Technology Corporation
    Inventor: George E. Pierce
  • Patent number: 6007583
    Abstract: Use of compounds of the formula ##STR1## where the radicals R.sup.1, R.sup.2 and A are as defined in the description, as bleach activators in bleaching detergents and cleaners.
    Type: Grant
    Filed: October 19, 1998
    Date of Patent: December 28, 1999
    Assignee: Clariant GmbH
    Inventor: Bernd Nestler
  • Patent number: 5968484
    Abstract: A cosmetic preparation which comprises a sunscreen agent for protecting the human epidermis against UV light in the range from 280 to 400 nm, which comprises, in a cosmetically suitable carrier, alone or together with compounds which absorb in the UV region and are known for cosmetic preparations, as photostable UV-A filters, effective amounts of compounds of the formula I ##STR1## where R.sup.1, R.sup.2 and R.sup.3 are hydrogen or aliphatic or cycloaliphatic radicals each having up to 18 carbon atoms, it being possible for any two of the radicals R.sup.1, R.sup.2 and R.sup.3 together to form a 5- or 6-membered ring, and R.sup.4 and R.sup.5 are an unsubstituted or substituted aromatic or heteroaromatic radical having 5 to 12 ring atoms, and R.sup.5 can additionally be hydrogen.
    Type: Grant
    Filed: August 22, 1997
    Date of Patent: October 19, 1999
    Assignee: BASF Aktiengesellschaft
    Inventors: Thorsten Habeck, Alexander Aumueller, Volker Schehlmann, Horst Westenfelder, Thomas Wunsch
  • Patent number: 5900502
    Abstract: According to the present invention there is provided a process for the selective introduction of one or more fluorine atoms into a disubstituted aromatic compound in an acid medium with fluorine gas characterized in that the acid medium has a dielectric constant of at least 20 and a pH of less than 3. The present process provides a cost effective means of selectively introducing one or more fluorine atoms into an aromatic compound in good overall yield.
    Type: Grant
    Filed: October 25, 1996
    Date of Patent: May 4, 1999
    Assignee: BNFL Fluorochemicals Limited
    Inventors: Christopher John Skinner, John Hutchinson, Julie Thomson, Richard Dickinson Chambers
  • Patent number: 5877381
    Abstract: The present invention provides a fluidized bed catalyst for the synthetic reaction of organic compounds which has a reduced catalyst loss. A fluidized bed catalyst for organic compound synthetic reaction, characterized in that 90% or more of the catalyst particles is in the range of 5-500 .mu.m on the weight-based particle size distribution and 90% or more of the 20-75 .mu.m particles has a crushing strength which satisfies the following equation:CS>A.multidot.d.sub..alpha.wherein CS represents a crushing strength ?g-weight/particle!,A represents a constant 0.001,d represents a particle diameter ?.mu.m!, and.alpha. represents a constant 2.
    Type: Grant
    Filed: July 1, 1996
    Date of Patent: March 2, 1999
    Assignee: Nitto Kagaku Kogyo Kabushiki Kaisha
    Inventors: Yutaka Sasaki, Hiroshi Yamamoto, Kiyoshi Moriya, Yoshimi Nakamura
  • Patent number: 5863750
    Abstract: The present invention describes methods for the detoxification of a mixture of nitrile compounds, or a mixture of nitrile and amide compounds by conversion of the nitrile compound(s) to the corresponding amide or acid compounds using a pure culture of an induced microorganism strain capable of converting a nitrile moiety to an amide or acid moiety. If an amide is formed or is present in the mixture, the amide can be further converted, using the present methods for detoxification, to the corresponding acid. The acid can then, if desired, be further degraded to CO.sub.2, H.sub.2 O and biomass. The induced pure cultures are able to detoxify a mixture of nitrites or a mixture of nitriles and amides which are typically present, in high concentration(s), in nitrile production waste streams.
    Type: Grant
    Filed: December 18, 1996
    Date of Patent: January 26, 1999
    Inventor: George E. Pierce
  • Patent number: 5847198
    Abstract: A process for the preparation of an ester, especially fluorinated esters R.sub.1 O.OC--CHR.sub.2 --CO.OR.sub.3, R.sub.1 and R.sub.3 are each independently selected from alkyl, cycloalkyl and aryl. R.sub.2 is selected from hydrogen, alkyl, cycloalkyl. The method includes the steps of covering a corresponding compound of formula 2: R.sub.1 O.OC--CHR.sub.2 --CO.OR.sub.3 in the presence of a base, of salt of a compound of formula 2, into corresponding compound of formula 1 by the reaction of elemental fluorine.
    Type: Grant
    Filed: December 12, 1997
    Date of Patent: December 8, 1998
    Assignee: F2 Chemicals Limited
    Inventors: Richard Dickinson Chambers, John Hutchinson, Julie Thomson
  • Patent number: 5756306
    Abstract: A process for producing an .alpha.-hydroxy acid or an .alpha.-hydroxyamide which comprises treating an aldehyde and prussic acid or an .alpha.-hydroxynitrile with a microorganism having nitrilase or nitrile hydratase activity in an aqueous medium and maintaining the aldehyde concentration and/or the .alpha.-hydroxynitrile concentration in the reaction mixture within a predetermined range. Also disclosed is a process for producing an .alpha.-hydroxy acid or an .alpha.-hydroxyamide from an aldehyde and prussic acid with a microorganism in an aqueous medium, which comprises maintaining the cyanogen concentration in the reaction mixture within a predetermined range and supplying the aldehyde to the reaction mixture at a predetermined ratio to the prussic acid.
    Type: Grant
    Filed: November 8, 1996
    Date of Patent: May 26, 1998
    Assignee: Nitto Chemical Industry Co., Ltd.
    Inventors: Yasumasa Yamaguchi, Masahiro Ushigome, Takeshi Kato
  • Patent number: 5670693
    Abstract: Salts of formula (III) ##STR1## wherein R.sup.1 represents CN or a C.sub.1 -C.sub.8 alkyl group, R.sub.2 a mononuclear C.sub.6 -C.sub.10 aryl group and R.sub.3 a C.sub.1 -C.sub.3 alkyl group or hydrogen; and of formula (IV) ##STR2## wherein R represents hydrogen or C.sub.1 -C.sub.3 alkyl, Aryl a C.sub.6 -C.sub.10 (substituted) phenyl group, and R', R" represent hydrogen and C.sub.1 -C.sub.4 alkyl or R'+R" together represent C.sub.4 alkylene anda process for their preparation by reaction of the thiocarbamate of a primary aliphatic amine, of a bis-amine or of cyanamide with a guanidine hydrohalide.
    Type: Grant
    Filed: July 12, 1996
    Date of Patent: September 23, 1997
    Assignee: Bayer AG
    Inventor: Hermann Lohwasser
  • Patent number: 5597940
    Abstract: Disclosed is a process for producing .beta.-nitroenamine represented by the formula I: ##STR1## wherein R.sub.1 and R.sub.2 are the same or different and independently indicate a hydrogen atom or a C.sub.1 -C.sub.10 alkyl group which may be optionally substituted with at least one group selected from the group consisting of a halogen atom, a lower alkoxy group, an aryloxy group, a hydroxyl group or an aryl group, or an aryl group which may be optionally substituted with a halogen atom, a lower alkyl group, a lower alkoxy group, an aryl group, an aryloxy group, a nitro group, a cyano group, an acylamino group, a di-lower alkylamino group, an arylamino group, a hydroxyl group, an arylsulfonyl group, a mercapto group, a lower alkylthio group or an arylthio group, R.sub.1 and R.sub.2 may bond together to form a cycloalkyl or bicycloalkyl and R.sub.3 is a hydrogen atom, a lower alkyl group, a cycloalkyl group or an aralkyl group; and an intermediate for producing the .beta.-nitroenamine.
    Type: Grant
    Filed: March 9, 1995
    Date of Patent: January 28, 1997
    Assignee: Sumitomo Chemical Company, Limited
    Inventor: Shinzo Seko
  • Patent number: 5344978
    Abstract: Certain N-acetonyl-substituted-amides of the formula: ##STR1## wherein A naphthyl; X, Y and Z are selected from the group consisting of hydrogen, halo, cyano, thiocyano, isothiocyano, thio(C.sub.1 -C.sub.2)alkyl, (C.sub.1 -C.sub.2)alkoxy, carbamoyl, dithiocarbomoyl, hydroxy, azide, thiophenyl, imidazolyl or triazolyl group as described herein; R.sup.1 and R.sup.2 are each independently a hydrogen atom or a (C.sub.1 -C.sub.6)alkyl group; and compositions containing these amides are fungicidally active, particularly against phytopathogenic fungi.
    Type: Grant
    Filed: December 21, 1992
    Date of Patent: September 6, 1994
    Assignee: Rohm and Haas Company
    Inventor: Ashok K. Sharma
  • Patent number: 5319135
    Abstract: An improved process for the preparation of cyclic amino acids by a novel synthesis is described where a dinitrile derivative is converted in two steps to the desired products, as well as valuable intermediates used in the process.
    Type: Grant
    Filed: June 4, 1993
    Date of Patent: June 7, 1994
    Assignee: Warner-Lambert Company
    Inventors: Rex A. Jennings, Don R. Johnson, Ronald E. Seamans, James R. Zeller
  • Patent number: 5231094
    Abstract: The present invention relates to the derivatives of the formula ##STR1## and their tautomeric forms, as well as their addition salts, and to their use in therapeutics, especially for the treatment of cardiovascular diseases and in particular for the treatment of hypertension, cardiac insufficiency and diseases of the arterial wall.
    Type: Grant
    Filed: April 6, 1992
    Date of Patent: July 27, 1993
    Assignee: Societe Anonyme: Laboratoires UPSA
    Inventors: Nicole Bru-Magniez, Timur Gungor, Jean-Marie Teulon
  • Patent number: 5212301
    Abstract: Introduction of a fluoro substituent into an aromatic ring adjacent an electron donating group is difficult producing mixed isomers and low yields of desired products.A process for the introduction of a fluoro substituent into a substantially adjacent position to an electron-donating group into an aromatic compound in high yield is disclosed.The fluoroaromatic compounds are useful as synthetic intermediates for example in the manufacture of agrochemicals, pharmaceuticals and dyestuffs.
    Type: Grant
    Filed: May 8, 1992
    Date of Patent: May 18, 1993
    Assignee: Imperial Chemical Industries PLC
    Inventors: John S. Moilliet, Richard D. Chambers, Michael H. Rock
  • Patent number: 5169975
    Abstract: Binary azulenesquaric acid dyes of the formula ##STR1## where X is a bridging member, Y is hydrogen, cyano or formula CO--OR.sup.5, CO--NHR.sup.5, OR.sup.5, O--CO--OR.sup.5, NH--CO--R.sup.5, NH--CO--OR.sup.5 or NH--SO.sub.2 --R.sup.5, where R.sup.5 is hydrogen, C.sub.1 -C.sub.12 -alkyl, C.sub.2 -C.sub.12 -alkenyl, C.sub.5 -C.sub.7 -cycloalkyl or unsubstituted or substituted phenyl, L.sup.1 and L.sup.2 are each, independently of one another, a chemical bond or unsubstituted or substituted C.sub.1 -C.sub.12 -alkylene and R.sup.1, R.sup.2, R.sup.3, R.sup.4, Q.sup.1, Q.sup.2, Q.sup.3 and Q.sup.4 are each, independently of one another, hydrogen or unsubstituted or substituted C.sub.1 -C.sub.12 -alkyl, their intermediates and an optical recording medium containing the novel dyes are described.
    Type: Grant
    Filed: November 15, 1991
    Date of Patent: December 8, 1992
    Assignee: BASF Aktiengesellschaft
    Inventors: Michael Schmitt, Bernhard Albert, Sibylle Brosius, Klaus D. Schomann, Harald Kuppelmaier
  • Patent number: 5132451
    Abstract: An improved process for the preparation of cyclic amino acids by a novel synthesis is described where a dinitrile derivative is converted in two steps to the desired products, as well as valuable intermediates used in the process.
    Type: Grant
    Filed: August 10, 1990
    Date of Patent: July 21, 1992
    Assignee: Warner-Lambert Company
    Inventors: Rex A. Jennings, Don R. Johnson, Ronald E. Seamans, James R. Zeller
  • Patent number: 5126374
    Abstract: Guanidines I ##STR1## (A=C.sub.5 -C.sub.12 -cycloalkyl which may bear up to three further substituents; benzyl substituted in the para-position; R.sup.1, R.sup.2, R.sup.3 =H, C.sub.1 -C.sub.4 -alkyl; R.sup.4 -C.sub.5 -C.sub.18 -alkyl which may be interrupted by oxygen, C.sub.5 -C.sub.18 -alkenyl, C.sub.4 -C.sub.18 -alkynyl or phenyl-C.sub.1 -C.sub.6 -alkyl, and these groups may bear up to three further substituents and the phenyl moiety of the phenylalkyl may additionally bear a phenoxy group or up to three C.sub.2 -C.sub.4 -alkenyl, C.sub.1 -C.sub.4 -alkoxy-C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.6 -alkyl or haloalkyl groups, C.sub.5 -C.sub.6 -cycloalkyl-C.sub.1 -C.sub.8 -alkyl, where the ring may bear up to three further substituents; A=benzyl and R.sup.4 =C.sub.3 -C.sub.4 -alkyl which may be interrupted by oxygen, or C.sub.4 -alkenyl, both of which may bear up to three further substituents; R.sup.3 +R.sup.4 =C.sub.5 -C.sub.
    Type: Grant
    Filed: July 3, 1990
    Date of Patent: June 30, 1992
    Assignee: BASF Aktiengesellschaft
    Inventors: Matthias Zipplies, Hubert Sauter, Franz Roehl, Eberhard Ammermann, Gisela Lorenz
  • Patent number: 5122435
    Abstract: Amido-containing azulene-aquaric acid dyes of the formula ##STR1## where L is C.sub.1 -C.sub.12 -alkylene which may be substituted by phenyl,R.sup.1 and R.sup.2 are each independently of the other hydrogen, substituted or unsubstituted C.sub.1 -C.sub.20 -alkyl, C.sub.5 -C.sub.7 -cycloalkyl, substituted or unsubstituted phenyl, 2,2,6,6-tetramethylpiperidin-4-yl or cyclohexylaminocarbonyl andR.sup.3, R.sup.4, R.sup.5 and R.sup.6 are each independently of the others hydrogen or substituted or unsubstituted C.sub.1 -C.sub.12 -alkyl,with the proviso that when R.sup.6 is hydrogen the positions of the substituents CH.sub.2 --L--CO--NR.sup.1 R.sup.2 and R.sup.5 on either or both azulene rings may also be interchanged with each other within an azulene ring are used in an optical recording medium.
    Type: Grant
    Filed: October 22, 1990
    Date of Patent: June 16, 1992
    Assignee: BASF Aktiengesellschaft
    Inventors: Michael Schmitt, Bernhard Albert, Sibylle Brosius, Klaus D. Schomann, Harald Kuppelmaier
  • Patent number: 5118827
    Abstract: Novel monocyclic terpene derivative of the formula: ##STR1## wherein R is hydrogen atom, trimethylsilyl group or 1-ethoxyethyl group, and novel intermediate therefor. The terpene derivative (I) is a useful intermediate for preparing Sarcophytol A having an anti-carcinogenesis promoter activity and an antitumor activity.
    Type: Grant
    Filed: July 16, 1990
    Date of Patent: June 2, 1992
    Assignee: Mitsubishi Kasei Corporation
    Inventors: Hisao Takayanagi, Yasunori Kitano, Yasuhiro Morinaka
  • Patent number: 5106984
    Abstract: 2-Hydrocarbyl-3,6-dichloropyridines are prepared from dichloromethyl hydrocarbyl ketones and acrylonitrile in a two-step process involving an addition reaction under basic conditions to form intermediate 1,1-dichloro-3-cyanopropyl hydrocarbyl ketones and a subsequent cyclization reaction in the presence of hydrogen chloride. Thus, 3,6-dichloro-2-methylpyridine is prepared from 1,1-dichloro-2-propanone and acrylonitrile by the formation and further reaction of 4,4-dichloro-5-oxo-hexanenitrile. The intermediates and products are novel compounds useful in the preparation of herbicides and nitrification inhibitors.
    Type: Grant
    Filed: February 24, 1987
    Date of Patent: April 21, 1992
    Assignee: The Dow Chemical Company
    Inventors: Marc E. Halpern, Jon A. Orvik, Thomas J. Dietsche
  • Patent number: 5068413
    Abstract: Processes for the preparation of cyclic amino acid derivatives useful in the treatment of cerebral diseases such as epilepsy are disclosed. Novel intermediates useful in processes are also disclosed.
    Type: Grant
    Filed: August 21, 1990
    Date of Patent: November 26, 1991
    Assignee: Godecke Aktiengesellschaft
    Inventors: Klaus Steiner, Wolfgang Herrmann, Gunter Crone, Charles S. Combs
  • Patent number: 5059709
    Abstract: A novel process for producing .alpha.-[(dialkylamino) substituted-methylene].beta.-oxo-(substituted) propanenitriles of the formula: ##STR1## where R, R.sub.1 and R .sub.2 are defined in the specification by reacting a substituted isoxazole with a diaklylamide dimethylacetal is provided.
    Type: Grant
    Filed: November 13, 1990
    Date of Patent: October 22, 1991
    Assignee: American Cyanamid Company
    Inventors: John P. Dusza, Robert F. Church
  • Patent number: 5047425
    Abstract: Compounds of the formula ##STR1## wherein Ar, R, R.sub.1, R.sub.2, R.sub.3, R.sub.4, X and n have the meanings mentioned in the description, processes and intermediates for their preparation, pharmaceutical compositions which contain them and their use in therapy in the treatment of cardiovascular diseases.
    Type: Grant
    Filed: November 30, 1988
    Date of Patent: September 10, 1991
    Assignee: Simes Societa Italiana Medicinali & Sintetici SpA
    Inventors: Cesare Casagrande, Francesco Santangelo, Luisa Calabi
  • Patent number: 5026886
    Abstract: A process is disclosed for preparing biaryl, bidentate ligands comprising:(1) contacting a biaryl compound having the structural formula: ##STR1## with a proton abstracting agent under conditions suitable to form a biaryl dianion, which is then(2) contacted with a Group V compound of the formula: ##STR2## where X' is halogen or a suitable leaving group.
    Type: Grant
    Filed: January 25, 1988
    Date of Patent: June 25, 1991
    Assignee: Eastman Kodak Company
    Inventors: Jerome L. Stavinoha, Gerald W. Phillips, Thomas A. Puckette, Thomas J. Devon
  • Patent number: 5008429
    Abstract: An improvement in a process for the industrial application of the Knoevenagel synthesis in an acid solution, resulting in a steady flow of waste gas.
    Type: Grant
    Filed: December 6, 1989
    Date of Patent: April 16, 1991
    Assignee: Huels Aktiengesellschaft
    Inventors: Manfred Kaufhold, Josef Metz
  • Patent number: 4900807
    Abstract: There are disclosed a nitrile-terminated Schiff compound represented by the formula X--Z--Y--C.tbd.N).sub.m (I) wherein n is 1 or 2, Z is --CH.dbd.N-- or --N.dbd.CH-- and Y is a divalent organic group such as phenylene and the like, and X is the same as Y when n=2 or H, lower alkyl group etc. when n=1; polymers obtained by polymerizing said Schiff compound alone or together with other monomers, and a process for preparing such a polymer therefrom.
    Type: Grant
    Filed: February 2, 1988
    Date of Patent: February 13, 1990
    Assignee: Hitachi, Ltd.
    Inventors: Akio Nishikawa, Toru Koyama, Hideki Asano, Toshikazu Narahara
  • Patent number: 4879310
    Abstract: The invention relates to new cyanonhydrin iodopropargyl ethers of the formula ##STR1## in which R denotes C.sub.1 -C.sub.10 -alkyl, C.sub.2 -C.sub.10 -alkenyl, C.sub.5-C.sub.8 -cycloalkyl or -cycloalkenyl, which can be optionally substituted by C.sub.1 -C.sub.4 -alkyl or halogen, a process for their preparation and their use as microbicides for the preservation of industrial materials.
    Type: Grant
    Filed: May 3, 1988
    Date of Patent: November 7, 1989
    Assignee: Bayer Aktiengesellschaft
    Inventors: Gerold Schade, Wilfried Paulus, Hans-Georg Schmitt
  • Patent number: 4861885
    Abstract: The present invention relates to amides of formula I ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3 are independently hydrogen or methyl, m is 1 to 5 and n is 1 to 5 and R.sup.4 is --NH.sub.2 or is derived from a mono- to pentavalent amine.Intermediates of formula VIII ##STR2## wherein R.sup.1, R.sup.2, R.sup.3 and m are as defined above and X is a carboxylic acid or acid ester group, --COCl, --COBr, --CHO or --CN, are also described.The compounds of formula I can be polymerized thermally. They are suitable for the preparation of adhesives, matrix resins or electrical insulating materials.
    Type: Grant
    Filed: December 8, 1986
    Date of Patent: August 29, 1989
    Assignee: Ciba-Geigy Corporation
    Inventors: Andreas Kramer, Roland Darms
  • Patent number: 4849530
    Abstract: The invention relates to novel crystalline salts of aryloxypropanolamines with diphenylacetic acid, a process for their preparation and the use of these salts for the preparation of chemically pure aryloxy-propanolamines or pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: June 6, 1988
    Date of Patent: July 18, 1989
    Assignee: Rorer Pharmaceutical Corporation
    Inventors: Gerhard Zol, Gerhard Pfarrhofer
  • Patent number: 4832733
    Abstract: Herbicidally active 3-amino-2-cyano-acrylic acid esters of the formula ##STR1## in which R.sup.1 represents alkoxyalkyl or benzyloxyalkylR.sup.2 represents alkyl or alkenyl,R.sup.3 represents hydrogen or alkyl,R.sup.4 represents hydrogen, or represents alkyl which is optionally substituted by hydroxyl, halogen, alkoxy or dialkylamino,X.sup.1 and X.sup.2 are identical or different and represent hydrogen, halogen, nitro, alkyl, alkoxy, alkylthio, halogenoalkyl, halogenoalkoxy, amino, alkylamino, alkylcarbonylamino, N-alkylcarbonyl-N-alkylamino, dialkylaminocarbonylamino or in each case optionally substituted aryl or aryloxy, orX.sup.1 and X.sup.2 together with the adjacent phenyl radical represent naphthyl andm represents the number 0, 1, 2, 3, 4 or 5.Intermediates of the formula ##STR2## are also new.
    Type: Grant
    Filed: April 3, 1987
    Date of Patent: May 23, 1989
    Assignee: Bayer Aktiengesellschaft
    Inventors: Joachim Kluth, Hans-Joachim Santel, Robert R. Schmidt
  • Patent number: 4767784
    Abstract: The invention relates to novel crystalline salts of aryloxypropanolamines with diphenylacetic acid, a process for their preparation and the use of these salts for the preparation of chemically pure aryloxy-propanolamines or pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: November 28, 1986
    Date of Patent: August 30, 1988
    Inventors: Gerhard Zolss, Gerhard Pfarrhofer
  • Patent number: 4760158
    Abstract: Novel 3-halo-2,2-disubstituted propanenitriles of formula ##STR1## wherein Z represents bromo or chloro and A, together with the carbon atom to which it is attached, represents a 5,6 or 7 membered saturated carbocyclic or heterocyclic ring, are useful as intermediates for preparing substituted pyrimido[1,2-a]indoles. The intermediates can be prepared by a novel process which comprises condensing a 2,2-disubstituted ethanenitrile with a dihalomethane in the presence of a non-nucleophilic strong base.
    Type: Grant
    Filed: March 9, 1987
    Date of Patent: July 26, 1988
    Assignee: John Wyeth & Brother Limited
    Inventors: Ian A. Cliffe, Richard S. Todd
  • Patent number: 4757127
    Abstract: A process for the preparation of phosphonic acid compounds of the formula ##STR1## wherein R.sub.1 and R.sub.2 are individually selected from the group consisting of aryl of 6 to 14 carbon atoms, optionally unsaturated alkyl of 1 to 8 carbon atoms, aryloxy of 6 to 14 carbon atoms, optionally unsaturated alkoxy of 1 to 8 carbon atoms and aralkoxy and aralkyl of 7 to 18 carbon atoms, or R.sub.1 and R.sub.2 together with a phosphorus atom form a ring, Y is selected from the group consisting of ##STR2## and --COOR.sub.3, R.sub.3 is selected from the group consisting of optionally unsaturated alkyl of 1 to 8 carbon atoms and optionally substituted, and ##STR3## R.sub.4 and R.sub.5 are individually selected from the group consisting of hydrogen, optionally unsaturated alkyl of 1 to 8 carbon atoms and aryl of 6 to 14 carbon atoms and R.sub.
    Type: Grant
    Filed: November 20, 1986
    Date of Patent: July 12, 1988
    Assignee: Roussel Uclaf
    Inventors: Jean Tessier, Van T. Truong
  • Patent number: 4722808
    Abstract: Cyclododecenylacetonitrile is prepared by reacting cyclododecanone with cyanoacetic acid in the presence of a catalyst. Purified cyclododecenylacetonitrile has a pleasant scent reminiscent of roses and lilies of the valley, containing additionally a musk note, and is suitable as a fragrance and as a fragrance component.
    Type: Grant
    Filed: April 29, 1986
    Date of Patent: February 2, 1988
    Assignee: Huels Aktiengesellschaft
    Inventors: Manfred Kaufhold, Andre Slagmulder
  • Patent number: 4652556
    Abstract: Compounds of the formula: ##STR1## wherein R is aryl of 6 to 12 carbon atoms or aralkyl of 7 to 14 carbon atoms either optionally substituted with 1 to 3 substituents independently selected from lower alkyl of 1 to 6 carbon atoms, lower alkoxy of 1 to 6 carbon atoms, lower alkylthio of 1 to 6 carbon atoms, lower alkylsulfinyl of 1 to 6 carbon atoms, lower alkylsulfonyl of 1 to 6 carbon atoms, halogen, trihalomethyl, nitro, cyano or carboxyl; alkyl of 1 to 10 carbon atoms, cycloalkyl of 3 to 10 carbon atoms, lower alkenyl of 2 to 6 carbon atoms, or lower alkynyl of 2 to 6 carbon atoms, all optionally substituted with 1 to 3 halogen atoms; lower alkoxyalkylene; lower alkylene carbalkoxy; lower alkylthioalkylene; lower alkylsulfinylalkylene; or lower alkylsulfonylalkylene; R.sup.1 and R.sup.2 are independently hydrogen, lower alkyl of 1 to 6 carbon atoms, aryl of 6 to 12 carbon atoms, or thienyl, or taken together form an alkylene bridge to give a cycloalkyl group of 3 to 10 carbon atoms; and R.sup.
    Type: Grant
    Filed: August 19, 1985
    Date of Patent: March 24, 1987
    Assignee: Chevron Research Company
    Inventors: Joseph E. Moore, Yuh-Lin Yang, Robert K. Griffith, David C. K. Chan