Abstract: Disclosed herein is a fluid infusion device of the type that delivers medication fluid to the body of a patient. The device includes or cooperates with a fluid reservoir, and the device has a sealing assembly to receive and form a fluid seal with the fluid reservoir. A retractable sealing element surrounding a hollow fluid delivery needle may be used to seal a port of the fluid reservoir. The port may include a pressure vent that is sealed by the retractable sealing element. In one variation, the reservoir includes a moving valve sleeve that holds a septum. The septum moves to allow the reservoir to vent, and to form a seal with the port when the needle pierces the septum. In another variation, the device includes a needleless sealing assembly. In yet other variations, the device uses a needled fluid reservoir.

Abstract: A fluid delivery device comprising a fluid reservoir; a transcutaneous access tool fluidly coupled to the fluid reservoir; and a drive mechanism for driving fluid from the reservoir, the drive mechanism comprising a plunger received in the reservoir; a leadscrew extending from the plunger; a nut threadably engaged with the leadscrew; a drive wheel; and a clutch mechanism coupled to the drive wheel, wherein the clutch mechanism is configured to allow the nut to pass through when disengaged and is configured to grip the nut when engaged such that the drive wheel rotates the nut to advance the drive rod and the plunger into the reservoir.

Abstract: An adhesive patch is secured to an infusion set, patch pump or other on-body medical device by an overmolding process during manufacture of the medical device, or during manufacture of a portion of the medical device, without the need for a separate adhesive. This provides a more secure connection between the patch and the medical device, and reduces the required number of adhesive layers from two (skin attachment side and device attachment side) to one (skin attachment side only), thereby simplifying the design and manufacture of the patch.

Abstract: A fluid treatment system for a percutaneous cable and methods of assembly and use are described herein. In one aspect, the fluid treatment system includes a delivery tube comprising a distal end and a proximal end. The distal end is configured to surround at least a portion of the percutaneous cable. The percutaneous cable extends from within a patient to outside the patient through tissue at an exit site. The proximal end is connectable to a fluid source. Fluid from the fluid source is configured to be delivered to the exit site through the delivery tube. The fluid treatment system includes an anchor coupleable to the percutaneous cable to secure the percutaneous cable to the tissue at the exit site.

Abstract: A system for treating an aneurysm in a blood vessel or vein, wherein the aneurysm has a dome, an interior, and a neck. The system includes a shape memory polymer foam in the interior of the aneurysm between the dome and the neck. The shape memory polymer foam has pores that include a first multiplicity of pores having a first pore size and a second multiplicity of pores having a second pore size. The second pore size is larger than said first pore size. The first multiplicity of pores are located in the neck of the aneurysm. The second multiplicity of pores are located in the dome of the aneurysm.

Abstract: Rapid exchange balloon catheter, and applications thereof. The balloon catheter includes a shaft and a guidewire channel. Shaft includes infusion and inflation walls. Infusion wall encloses an infusion lumen and comprises fluid inlet and fluid outlet located distally to fluid inlet. The inflation lumen extending axially therealong opened at a distal end thereof into an inner volume of a dilatation balloon. Guidewire channel is sized to closely fit over a pre-scribed guidewire for allowing unhindered passing therethrough with the guidewire. Guidewire channel includes a channel distal end protruding distally from the balloon with a distal guidewire opening, and a channel proximal end with a proximal guidewire opening at the shaft between fluid inlet and fluid outlet. Applications include methods for angioplasty and revascularization in which a single balloon catheter is used for dilatation and/or occlusion, and for delivering fluid proximally to the balloon.

Abstract: Provided herein are systems and methods for monitoring one or more health or physiological parameters in a subject. The systems and methods may comprise a patch coupled to an injector. Data may be transmitted to a mobile device or remote server, where the data may be processed. Processed data may be used to inform a subject on a health or physiological condition.

Abstract: Disclosed is a catcher (100), comprising an catching ring (11) and at least one connecting rod (15), wherein both ends of the connecting rod (15) are connected to the catching ring (11), and the connecting line between the two ends of the connecting rod (15) is located within the catching ring (11). Compared with catching loops in the prior art, the catching ring (11) of the catcher (100) is a ring structure supported by the connecting rod (15), thereby having a relatively high stability and not easily being deformed under erosion by a blood flow, so as to facilitate accurate positioning by a doctor during clinical operations and improve the success rate of withdrawal.

Abstract: Drug delivery system, injection device, transfer apparatus, vial holder and method of administering and transferring are disclosed. The system may include transfer apparatus and an injection device. The transfer apparatus may have receiving stations for a drug source, such as a vial or vial holder, and for an injection device, and fluid flow pathways for transferring drugs from the source into the injection device. The injection device may include an expandable elastic bladder and an injection cannula that is movable between a plurality of positions.

Abstract: A modular dilation device (100) is provided for inserting multiple dilators into a target patient tissue site. The modular dilation device includes a first dilator (104) and a second dilator (530). The first dilator has a first dilator distal end (108) and a first dilator inner lumen (114). The first dilator has a first dilator side wall opening (118). The first dilator distal end has a first dilator open tip (116). The first dilator has a first dilator open slit (120). The first dilator open slit extends between the first dilator side wall opening and the first dilator open tip. The second dilator has a second dilator distal end and a second dilator inner lumen. The second dilator distal end has a second dilator open tip. When the second dilator is joined to the first dilator, the second dilator open tip is adjacent to the first dilator side wall opening.

Abstract: Embodiments may include a method of delivering a drug. The method may include removing or releasing a structure from a patch-pump assembly. The patch-pump assembly may include a sealed prefilled drug-reservoir, a fluid passageway, a cannula-containing assembly, and a penetrator. The method may also include penetrating the sealed prefilled drug-reservoir containing the drug to establish fluid communication between the sealed prefilled drug-reservoir and a fluid passageway by removing or releasing the structure. The method may further include flowing the drug from the prefilled drug-reservoir to the fluid passageway. In addition, the method may include flowing the drug from the fluid passageway to a cannula-containing assembly. Furthermore, the method may include delivering the drug subcutaneously to a subject using the cannula-containing assembly.

Abstract: A cannula insertion device is disclosed. The device includes a needle carriage, a rail device on which the needle carriage is slidable, a yoke having a channel, a linkage connected to the needle carriage and extending into the channel, a torsion spring with one end connected to the linkage, and locking device for locking the torsion spring in tension and maintaining the needle carriage and the linkage in a locked position prior to activation. Upon release of the locking device, the tension of the torsion spring is released, which causes the linkage to move in the channel and slide the needle carriage along the rail device. A catheter carriage may also be provided for actuation by the linkage.

Abstract: Technologies are described for delivering an active agent using an ingestible pill device, securing medication package content, and monitoring the medication package content. Examples of the technology include using an ingestible pill device to deliver an active agent, where release of the active agent can be based on patient authentication, analyzing sensor data to determine a condition for releasing the active agent, analyzing image data to identify a release point, etc. Examples of the technology also include using a monitoring device to secure a medication package using a cover and locking device, monitoring the medication package to detect access to the medication package, and tracking access to the medication package to determine medication adherence.

Abstract: Devices and methods for the treatment of chronic total occlusions are provided. One disclosed embodiment comprises a method of facilitating treatment via a vascular wall defining a vascular lumen containing an occlusion therein. The method includes providing a first intravascular device having a distal portion with a concave side, inserting the first device into the vascular lumen, positioning the distal portion in the vascular wall, and orienting the concave side of the distal portion toward the vascular lumen.

Abstract: A surgical apparatus comprises a body, a shaft assembly, a rotation input assembly, and an end effector. The shaft assembly defines a longitudinal axis and a first fluid passageway. The rotation input assembly is operable to rotate the shaft assembly about the longitudinal axis. The rotation input assembly defines a second fluid passageway. The second fluid passageway is in fluid communication with the first fluid passageway. The end effector is located at a distal end of the shaft assembly. The end effector comprises an ultrasonic blade. The end effector is in fluid communication with the first fluid passageway such that the end effector is configured to receive fluid communicated through the first and second fluid passageways.

Abstract: The present application relates to an infusion set (80). The infusion set (80) has a base (90) for mounting on a user, and a connector (100) which engages with the base (90) to form a flow path between the connector (100) and a cannula mountable on the base (90). The connector (100) is configured to be selectably mountable to the base (90) in at least two predetermined mounting orientations. The present application also relates to an infusion set base (90), an infusion set connector (100), an infusion set cannula, and a method of assembling an infusion set (80).

Abstract: A method and a kit for the prevention of venous stenosis associated with the use of hemodialysis AV shunts. The kit may use a bifurcated needle for providing access to the shunt or blood vessel. One of the arms is used for returning the blood to the subject after dialysis treatment, while the other arm is used for inserting a device for cleaning the vein, the device being either an autonomous crawling device, or a passive tethered device moved down the vein by the blood flow. The autonomous crawling device may be a series of sequentially inflatable chambers, the stenosis being cleared by pressure from the outer walls of the chambers when inflated and moved. The passive device may be an element having a flexible disc-like structure, whose flexible peripheral edge slides along the inner walls of the blood vessel, compressing or clearing the material attached thereto.

Abstract: The present disclosure relates to a medicament delivery device comprising: a housing, a plunger rod received by the housing, which plunger rod is rotatable in a first direction relative to the housing and linearly displaceable, an activation button arrangement linearly displaceable from a first position to a second position to thereby rotate the plunger rod in the first direction, a second direction rotation preventer having an annular outer member that is rotationally fixed relative to the housing and an annular inner member partially received by the outer member, wherein the outer member and the inner member are arranged to receive the plunger rod and wherein the inner member is rotationally interlocked with the plunger rod, wherein the outer member and the inner member are structured to allow the inner member to rotate in the first direction relative to the outer member and to prevent the inner member from rotating in a second direction opposite to the first direction, and a recording unit comprising: a fi

Abstract: Thrombectomy catheter systems, accessory devices, and methods for making and using such devices are disclosed. An example thrombectomy system may include a catheter shaft having a proximal portion, a distal portion, and a lumen extending at least partially through the catheter shaft. A high pressure tube may be disposed within the lumen. The high pressure tube may be designed for communication with a fluid source. A fluid jet emanator may be coupled to the high pressure tube. The fluid jet emanator may have at least one jet orifice. The catheter shaft may include a first orifice disposed proximally of a distal end of the catheter shaft and a second orifice disposed proximally of the first orifice. An accessory device may be disposed within the lumen. The accessory device may include a helical distal region.

Abstract: A surgical access system includes a cannula assembly and an obturator assembly. The obturator assembly provides an insufflation channel or fluid passage for delivery of insufflation fluids directly to an underlying cavity, e.g., the abdominal cavity. The fluid passage is completely confined within the obturator assembly isolated from the cannula assembly and terminates at a location distal of the cannula assembly such that the insufflation fluids released from the fluid passage are directed toward the abdominal cavity and not within the cannula assembly.

Abstract: A system, method, and computer program product for identifying device connections in a connection area includes receiving a plurality of physical parameters of a plurality of devices from a plurality of transmission sources in a connection area, wherein the plurality of physical parameters indicates physical states of the plurality of devices. At least one physical connection state is determined between the plurality of devices based on the plurality of physical parameters of the plurality of devices.

Abstract: An infusion state detection system includes: a pump unit configured to deliver a liquid in an infusion line; a pressure detector configured to detect a pressure in the infusion line; and a determination processing unit configured to: when the pressure detected by the pressure detector is at a predetermined value or above, stop driving of the pump unit for a stop period, and determine an infusion state on the basis of a value of the pressure detected by the pressure detector during the stop period.

Abstract: In one aspect, an arteriovenous access valve system may generally include a first valve configured to be positioned at or adjacent to an end of arteriovenous graft and a second valve configured to be positioned at or adjacent to an opposite end of the arteriovenous graft. In addition, the system may include an actuator assembly in fluid communication with the first and second valves. The actuator assembly may include a housing, a driver assembly positioned within the housing and a drive magnet positioned within the housing. The drive magnet may be rotatably coupled to the driver assembly such that, when the drive magnet is rotated, the driver assembly is configured to be rotatably driven so as to supply fluid to the first and second valves or to draw fluid out of the first and second valves depending on a rotational direction of the driver assembly.

Abstract: An apparatus to preserve liquid from a medicine vial may include a vial coupling member forming a vial coupling member cavity and a container forming a cavity. The apparatus may further include a first fluid pathway forming a first lumen that is in fluid communication with the vial coupling member cavity and the cavity and a second fluid pathway forming a second lumen that is in fluid communication with the vial coupling member cavity and the cavity. The vial coupling member cavity, the cavity, the first lumen, and the second lumen may form a sterile environment that is sealed from contaminants in an ambient environment. The apparatus may include a disengaging member configured to permit the container to disengage from the first fluid pathway and the second fluid pathway while permanently sealing at least one of the first lumen or the second lumen.

Abstract: A system and method are provided for preventing a sharp stick hazard from a needle tip of an automatic injector device. In some embodiments, a skin contact surface of the device is attached to an injection site, for example by an adhesive. Optionally a locking mechanism holds a needle extended into an injection site. A body of the device is optionally movably attached to the skin contact surface. Pulling the body away from the injection site optionally moves the body with respect to the skin contact surface. Movement of the body with respect to the skin contact surface optionally moves interlinked parts of the locking mechanism, releasing the locking mechanism.

Abstract: A method of manufacturing an ultrasonic transmission component of an ultrasonic surgical instrument includes forming, via additive manufacturing, a waveguide, including a body portion, a curved blade extending distally from the body portion, and a lumen extending through a portion of the body portion and a portion of the curved blade. Another method of manufacturing an ultrasonic transmission component of an ultrasonic surgical instrument includes forming, via additive manufacturing, a waveguide, including a body portion and a blade extending distally from the body portion. At least one of the body portion or the blade defines a varied density.

Abstract: Procedural methods are provided that are capable of forming a protuberant region, in which the surface of a living body protrudes, in a less-invasive manner and a medical device capable of forming the protuberant region in a less-invasive manner. A procedural method for forming a protuberant region, in which a surface of a living body protrudes, includes an introduction step of introducing a container having flexibility into the living body, a protuberant region forming step of forming the protuberant region, in which the surface of the living body protrudes, by filling the container with a filling material to expand the container, and a placement step of placing the expanded container in the living body.

Abstract: A method of manufacturing an ultrasonic transmission component of an ultrasonic surgical instrument includes forming, via additive manufacturing, a waveguide, including a body portion, a curved blade extending distally from the body portion, and a lumen extending through a portion of the body portion and a portion of the curved blade. Another method of manufacturing an ultrasonic transmission component of an ultrasonic surgical instrument includes forming, via additive manufacturing, a waveguide, including a body portion and a blade extending distally from the body portion. At least one of the body portion or the blade defines a varied density.

Abstract: A trigger operated syringe (100) for intramammary injection of antibiotics has a fluid containing syringe cartridge (203) activated by a plunger (206) which is inserted into the syringe cartridge (203A) and expels fluid when the trigger (205) is pulled. A syringe cartridge holding mechanism (223) holds the syringe cartridge in place until the trigger (205) is released and the plunger (206) retracted. Single syringe cartridge (203) and multiple syringe cartridge (204) versions are disclosed. The plunger moves in a direction which is effectively perpendicular to the direction of movement of the trigger, allowing for ease of injection to a cow's teats, and ejection of the spent cartridges.

Abstract: Adhesive assemblies and microneedle injection apparatuses comprising same. The apparatus (100) can include a housing (102) having a base and an opening (115) formed in the base; and an applicator comprising a microneedle array (104), the microneedle array comprising a first major surface (111) and microneedles (105). The applicator can be movable between a first position, and a second position in which at least a portion of the microneedle array extends through the opening in the base. The apparatus can further include an adhesive assembly (118), which can be adhered to the base of the housing. The adhesive assembly can include an extension (125) that extends at least partially into the area defined by the opening, such that when the applicator is in the second position, at least a portion of the first major surface of the microneedle array is in contact with the extension of the adhesive assembly.

Abstract: A device for treating tissue may include a tissue expander configured to be inserted into a body lumen and stretch tissue surrounding the body lumen, and a tool configured to be coupled to the tissue expander and move along a path defined by the tissue expander.

Abstract: A gas mixture apparatus includes a measurement control system, an activation system, a pressurized chamber with one or more gases, and a mixing chamber. The apparatus can also include additional pressure regulation control systems. The gas mixture apparatus can be used to introduce and automatically perform the steps to achieve a desired concentration of the one or more gases contained in the pressurized chamber. The gas mixture apparatus can include the pressurized chamber within the apparatus itself such that no external devices are necessary for introducing the one or more gases into the mixing chamber.

Abstract: A fluid delivery device comprising a fluid reservoir; a transcutaneous access tool fluidly coupled to the fluid reservoir; and a drive mechanism for driving fluid from the reservoir, the drive mechanism comprising a plunger received in the reservoir; a leadscrew extending from the plunger; a nut threadably engaged with the leadscrew; a drive wheel; and a clutch mechanism coupled to the drive wheel, wherein the clutch mechanism is configured to allow the nut to pass through when disengaged and is configured to grip the nut when engaged such that the drive wheel rotates the nut to advance the drive rod and the plunger into the reservoir.

Abstract: A supplemental device for attachment to an injection device including a dosage window covering a sleeve on which dose values are marked is provided. The supplemental device comprises: a main body; an arrangement for supporting the main body of the supplemental device in a predetermined positional relationship with the injection device; a transparent protection window located at a surface of the main body that is aligned with the dosage window of the injection pen when in use; and a sensor arrangement supported in the main body and having a sensor directed at the protection window. The protection window has an optical power. The protection window may be a cylindrical lens or a toric lens.

Abstract: Embodiments may include a method of delivering a drug. The method may include removing or releasing a structure from a patch-pump assembly. The patch-pump assembly may include a sealed prefilled drug-reservoir, a fluid passageway, a cannula-containing assembly, and a penetrator. The method may also include penetrating the sealed prefilled drug-reservoir containing the drug to establish fluid communication between the sealed prefilled drug-reservoir and a fluid passageway by removing or releasing the structure. The method may further include flowing the drug from the prefilled drug-reservoir to the fluid passageway. In addition, the method may include flowing the drug from the fluid passageway to a cannula-containing assembly. Furthermore, the method may include delivering the drug subcutaneously to a subject using the cannula-containing assembly.

Abstract: A thrombectomy catheter includes a catheter body having a catheter lumen. An outflow orifice is positioned along a catheter perimeter. A fluid jet emanator communicates with a high pressure tube. The fluid jet emanator includes at least one jet orifice for directing a fluid jet from the fluid jet emanator through the catheter lumen toward the outflow orifice. The fluid jet emanator provides a jet stream from the catheter body through the outflow orifice. The jet stream includes first and second stream portions. An entrainment fluid flow circuit includes at least the first stream portion, and the entrainment fluid flow circuit entrains particulate and macerates the particulate therein. An exhaust fluid flow path includes the second stream portion, and the exhaust fluid flow path draws entrained particulate from the entrainment fluid flow circuit at a location exterior to the catheter body and directs it toward the catheter proximal portion.

Abstract: Provided is a catheter, which can protect a medical personnel and a patient from a needle stick injury when it is disposed of after use. In an example embodiment, the catheter includes a needle, a plug having a front end coupled to the needle, a first case formed to enclose the needle, a socket coupled to a front end of the first case, a gear vertically coupling the first case and the socket to each other and having a tooth formed on an outer periphery of one side and a needle groove formed therein to allow the needle to pass therethrough, a catheter hub fastened by the tooth of the gear, and a tube coupled to the front end of the catheter hub.

Abstract: Disclosed is a skin adherable device for delivering therapeutic fluid into a body of a patient. The device includes a monitoring apparatus, a dispensing apparatus, and a tip for delivering the therapeutic fluid into the body of the patient and for monitoring bodily analyte in the body of the patient. The dispensing apparatus may continuously deliver the therapeutic fluid to the body of the patient and the monitoring apparatus may continuously monitor bodily analytes of the patient.

Abstract: A supplemental device for attachment to an injection device including a dosage window covering a sleeve on which dose values are marked is provided. The supplemental device comprises: a main body; an arrangement for supporting the main body of the supplemental device in a predetermined positional relationship with the injection device; a transparent protection window located at a surface of the main body that is aligned with the dosage window of the injection pen when in use; and a sensor arrangement supported in the main body and having a sensor directed at the protection window. The protection window has an optical power. The protection window may be a cylindrical lens or a toric lens.

Abstract: An infusion device comprising a fluid reservoir for containing a therapeutic fluid; and a transcutaneous access tool fluidly coupled to the fluid reservoir for delivering the therapeutic fluid subcutaneously and for introducing a monitoring test strip subcutaneously, and methods of use thereof.

Abstract: The invention pertains to implantable medical devices for controlled delivery of therapeutic agents. Some devices according to the invention have a titanium reservoir, and a porous titanium oxide based membrane to control the rate of release of the therapeutic agent. The reservoir contains a formulation of the active agent, including a stabilizer for the active agent, wherein the stabilizer is provided in an extended release configuration.

Abstract: An embolic protection device for capturing emboli in a body vessel having a frame and a z-stent waist band. The frame includes a plurality of struts configured to open radially to define an expanded state of the device for capturing emboli and to fold along the longitudinal axis to define a collapsed state of the device for deployment and retrieval. The waist band has an open and a closed state and is attached to within the frame between a proximal and distal end. The waist band is formed of a plurality of members attached at a joint to an adjacent member such that the members lie substantially parallel in the closed state and form a “Z” pattern in the open state. A filter portion is attached to the waist band and configured to capture emboli in the expanded state.

Abstract: Blood flow into vascular tissue is filtered in a manner that can also be useful for trapping particulates while allowing the flow of blood. Consistent with one or more embodiments, a filter apparatus includes a filter, an outer delivery sheath such as a catheter, and one or more shafts that are operable to manipulate the shape of the filter for positioning within vascular tissue. The filter conforms to various types of vascular tissue, and filters blood flow passing through openings in the vascular tissue. In some implementations, the filter is used to trap particulates that have been collected on the filter, and collapses to trap and draw the particulates into the outer delivery sheath.

Abstract: A coupling system includes an applicator tool and an attachment ring mounted on the applicator tool. Clips are contained within the applicator tool and are deployed through the attachment ring in order to anchor the attachment ring to biological tissue. When deployed, tips of the clips follow a curved trajectory through an annular cuff of the attachment ring and through the underlying tissue. The tips loop back out of the tissue and to a location where they are later trapped or clamped by the attachment ring. While the tips are trapped or clamped, the applicator tool cinches the clips by pulling rear segments of the clips. Thereafter, the applicator tool disconnects from the attachment ring which remains anchored to the tissue and serves as a coupling for a cannula. The cannula can have movable lock members that secure it to the attachment ring.

Abstract: A device for retrieval of a vena cava filter is provided. The retrieval device has, approximately, an umbrella shape and consists of a central shaft; a plurality of frame struts, attached to frame strut attachment points on the central shaft and disposed radially about the central shaft; and a plurality of snare wires. The retrieval device has a collapsed configuration for insertion and removal from a blood vessel of a patient and an expanded state for capturing an intravascular filter in the blood vessel of the patient. The plurality of snare wires provides multiple points at which a vena cava filter, particularly one that has become misaligned during deployment or treatment, can be caught. The frame struts can be substantially sinusoidal in shape and made of shape memory metal, such as Nitinol. The snare wires can be made of a biocompatible material such as silk, polyester, polypropylene, or nylon.

Abstract: An infusion set adapted to be secured to a skin surface includes a fixed base member connectable to the skin surface and a movable member. A needle or cannula is connected to the movable member and movable relative to the fixed base member. The movable member is movable from a first position in which the needle or cannula is not exposed externally of the fixed base member to a second position in which the needle or cannula is exposed externally of the fixed base member. A release member retains the movable member in the first position. Removal of the release member allows movement of the movable slide member to the second position.

Abstract: An embolic protection device for use in a patient's blood vessel, such as the aorta, has an approximately cylindrical outer structure made of a filter mesh material and an approximately conical inner structure also made of a filter mesh material. On the downstream end of the embolic protection device, the wider end of the conical inner structure is joined to the cylindrical outer structure. The upstream end of the embolic protection device is open for blood to flow between the conical inner structure and the cylindrical outer structure. The space between the conical inner structure and the cylindrical outer structure defines a collection chamber for captured emboli. The narrow upstream end of the conical inner structure has a catheter port with a resilient seal that is sized for passage of a catheter shaft. The filter mesh material may be self-supporting or it may be supported on a resilient-framework or an inflatable framework.

Abstract: The present invention provides a selectively activatable patch-pump assembly, said patch-pump assembly comprising: • a sealed prefilled drug-reservoir containing a drug to be delivered; • an associated conduit in connection therewith; • a selectively activatable penetrator which penetrates said sealed prefilled drug-reservoir and facilitates drug access to said conduit; and • a selectively activatable, associated, cannula-containing assembly for delivering a drug subcutaneously to a subject, in fluid connection with said conduit; wherein a selective activation-step initiates penetration of said sealed prefilled drug-reservoir, drug access from said drug-reservoir to said conduit, drug access from said conduit to said cannula-containing assembly and delivery from said cannula-containing assembly, thereby being a selectively activatable patch-pump assembly.

Abstract: An apparatus and methods for delivery of reinforcing materials to a weakened or fractured bone is disclosed. An apparatus for delivering a reinforcing mixture to a bone including a tube having a proximal end, a distal end, and a longitudinal axis therebetween, wherein the tube has at least one inner lumen capable of allowing a bone reinforcing mixture to pass therethrough; a balloon engaging the tube wherein the balloon expands from a substantially deflated state to a substantially inflated state upon the bone reinforcing mixture entering the balloon; and at least one light guide extending through the tube into the balloon to guide a light into the balloon.

Abstract: Described is a cartridge comprising a body adapted to contain a medicament, a bung slidably disposed in the body and having a distal face and a proximal face, and a light element coupled to a component of the cartridge. Further described is a medicament delivery device comprising the cartridge, a first receiver adapted to receive an optical signal from the light element and convert the optical signal into a first electrical signal, and a second receiver adapted to receive an optical signal from the light element and convert the optical signal into a second electrical signal.