Abstract: There is disclosed a system and methods to estimate physiological parameters. In accordance with embodiments a method is disclosed which includes generating distribution data for a plurality of signals. The method may also include deconvolving one of the plurality of signals from the other plurality of signals to produce clean signals. The clean signals may then be used to calculate physiological parameters.

Abstract: The invention relates to a method for calibrating a spectrometer equipped with a CCD array, the CCD array recording a spectrum from a reference volume emitter. The raw data hereby recorded are used to generate a function which describes an etaloning effect that occurs, said function being saved in the spectrometer as a correction function for measurements obtained from volume emitters.

Abstract: A clip-style pulse sensor may be adapted to apply limited, even pressure to a patient's tissue. A clip-style sensor is provided that reduces motion artifacts by exerting limited, uniform pressure to the patient tissue to reduce tissue exsanguination. Further, such a sensor provides a secure fit while avoiding discomfort for the wearer.

Abstract: A noninvasive physiological sensor for measuring one or more physiological parameters of a medical patient can include a bump interposed between a light source and a photodetector. The bump can be placed in contact with body tissue of a patient and thereby reduce a thickness of the body tissue. As a result, an optical pathlength between the light source and the photodetector can be reduced. In addition, the sensor can include a heat sink that can direct heat away from the light source. Moreover, the sensor can include shielding in the optical path between the light source and the photodetector. The shielding can reduce noise received by the photodetector.

Abstract: A method of processing first and second signals obtained by measuring a medium, to obtain a pulse wave signal and an artifact signal which are separated, includes: separating vectors of the first and second signals by using a separation matrix into a vector of the pulse wave signal and a vector of the artifact signal, the separation matrix including a norm ratio of a stable zone of the pulse wave signal and a compensated norm ratio of an artifact zone.

Abstract: Present embodiments are directed to a monitor system, such as a pulse oximetry system. The system may include a detection feature, an emission feature capable of emitting light into tissue and arranged relative to the detection feature such that the detection feature is capable of detecting the light from the tissue after passing generally through a portion of the tissue, a modulator capable of modulating the light to generate photon density waves at a modulation frequency generally in a range of 50 MHz to 3 GHz, a detector communicatively coupled with the detection feature, wherein the detector is capable of detecting characteristics of the photon density waves comprising amplitude changes and phase shifts, and a processor capable of making determinations relating to a value of a physiologic parameter of the tissue based at least in part on the detected characteristics.

Abstract: An optical sensor having a cover layer, an emitter disposed on a first side of the cover, a detector disposed on the first side of said cover, and a plurality of stacked independent adhesive layers disposed on the same first side of the cover, wherein the top most exposed adhesive layer is attached to a patient's skin. Thus, when the sensor is removed to perform a site check of the tissue location, one of the adhesive layers may also be removed and discarded, exposing a fresh adhesive surface below for reattachment to a patient's skin. The independent pieces of the adhesive layers can be serially used to extend the useful life of the product.

Abstract: A spectrophotometric sensor assembly for non-invasive monitoring of a blood metabolite within a subject's body tissue is provided that includes a pad, a light source, and a light detector The light source is operative to emit light signals of a plurality of different wavelengths. The light detector is operative to detect light emitted by the light source and passed through the subject's body tissue. The light detector is at least partially enclosed in EMI shielding. In some embodiments, the light detector and EMI shielding are disposed in a detector housing that encloses the light detector and shielding. The housing is aligned with a detector aperture disposed in the pad.

Abstract: Optical sensor devices, image processing devices, methods and computer readable code computer-readable storage media for detecting biophysical parameters, chemical concentrations, chemical saturations and blood count. In some embodiments, the image processing device receives a live still or video electronic image. Exemplary physiological parameters include but are not limited to a pulse rate, blood pressure, glucose, stroke volume of internal or external tissue (e.g. skin). A biophysical or physiological property is not limited to a cardiovascular or liver or the kidneys or to a cardiovascular disorder or to a pulmonary disorder. Exemplary chemical concentrations or saturation includes but not limited to a pH level, a glucose level, a urea nitrogen level, a CO2 concentration or saturation, or a oxygen concentration or saturation. In some embodiments the parameters are detected from a food or a beverage such as an alcohol, a dairy product, wine, a baked good, a fruit or a vegetable.

Abstract: A probe holder mounting device for a biological photometric device includes: a probe holder having a plurality of probe mounting parts to which optical fiber probes are mounted; a band-like mounting device body having a plurality of insertion holes into which the probe mounting parts are to be inserted to fix the probe holder in position by means of the insertion holes; belts whose one ends are respectively connected to both longitudinal ends of the mounting device body and whose other ends are engaged with each other; and an adjusting belt connected to the mounting device body at a position where the probe holder is fixed in position in a lateral direction of the mounting device body.

Abstract: In one embodiment, the invention provides an imaging device having a light source, a photo-sensor and a scanning assembly. In some embodiments, the light source is fixedly mounted in the first end of an elongated sheath and is adapted for illuminating a target, and the photo-sensor is mounted on the scanning assembly, also in the first end of the elongated sheath, and is adapted to detect light energy from the target. In other embodiments, the light source is movably mounted and the detector is held stationary. In other embodiments, both the light source and the photo-sensor are movably mounted. The scanning devices synchronously capture light energy from each of a plurality locations on the target, the light energy resulting from illumination by the light source, and synchronously digitizes the output from the photo-sensor from each of the plurality of locations on the target to generate an image of the target.

Abstract: According to embodiments, a medical sensor may be configured for use on mucosal tissue. Such a sensor may include a portion that facilitate the application of the sensor to the tissue and a portion that includes the optical components of the sensor. The two portions of the sensor may be reversibly coupled to one another. In embodiments, such sensors may be used to determine patient hematocrit.

Abstract: The present disclosure generally relates to a medical sensor configured to attach to a patient's finger. According to embodiments, a sensor body is attached to a ring such that the sensor body is limited to contact with the patient's finger. The ring may have a fixed diameter or be adjustable. The ring may also include an indicator that facilitates the determination of whether the ring applies appropriate tension to the patient's finger. The sensor body may comprise a strip attached to the ring at two points or a hood that covers the distal end of the patient's finger. The sensor body may be coupled to the patient's finger with adhesives or securing flaps.

Abstract: There is provided a biological information measuring apparatus, which permits to release constriction of capillary vessels a human body to provide stable measurement results of biological information and a proper S/N ratio. The biological information measuring apparatus 1 includes a beam-emitting type sensor device 10 provided on a mounting unit 2 to optically measure biological information of a subject 4. The beam-emitting type sensor device 10 is placed in a position so as to be in a non-contact state relative to the subject 4 when measuring the biological information.

Abstract: In a probe device including a light irradiating portion irradiating a light to a surface of a living body, and a light detecting portion detecting the light passing through an inner portion of the living body so as to emit from the surface of the living body, the probe device is provided with a sheet-like probe holding body, a plurality of light emitting probes and a plurality of detection probes which are attached to the probe holding body at a predetermined interval, a board holding portion attached to a predetermined position of the probe holding portion, an electronic board attached to the board holding portion, a sheet holding portion holding the probe holding body at a predetermined position of a head portion (a tested position) of the test subject, and a fixing band portion for installing the sheet holding portion to the test subject.

Abstract: A method for monitoring bladder function in an animal having a bladder, the method including positioning of a light emitter and a light detector on the animal's skin adjacent to the animal's bladder, emitting light at the bladder with the emitter while detecting light with the detector, and collecting data representative of detected light during bladder activity, to provide an indication of bladder function. Also provided are light shield apparatus and filter apparatus for near infrared spectroscopy (NIRS) bladder monitoring.

Abstract: Systems and methods for determining a physiological parameter in a patient are provided. In certain embodiments, a system can include an analyte detection system configured to measure first analyte data in a fluid sample received from a patient, a medical sensor configured to measure second analyte data in the patient, and a processor configured to receive the first analyte data and the second analyte data and to determine a physiological parameter based at least in part on the first analyte data and the second analyte data. In certain such embodiments, the medical sensor may be a pulse oximeter, and the physiological parameter may include a cardiovascular parameter including, for example, cardiac output.

Abstract: In order to provide a non-invasive and continuous concentration measurement with the technology of standard pulse oximeters, an a priori relationship is created, through an in-vivo tissue model including a nominal estimate of a tissue parameter indicative of the concentration of a blood substance. The a priori relationship is indicative of the effect of tissue on in-vivo measurement signals at a plurality of wavelengths, the in-vivo measurement signals being indicative of absorption caused by pulsed arterial blood. In-vivo measurement signals are acquired from in-vivo tissue at the plurality of wavelengths and a specific value of the tissue parameter is determined based on the a priori relationship, the specific value being such that it yields the effect of the in-vivo tissue on the in-vivo measurement signals consistent for the plurality of wavelengths. The specific value then represents the concentration of the substance in the blood.

Abstract: The present invention relates to an active transdermal analyte detection system performing extraction and detection of body analytes comprising of a patch accepting at least one electrical input; a plurality of transducers configured for converting input electrical energy to different forms of energies for activating extraction procedure; a controller configured for providing the control signals, intensity, sequence, nature, and timing information for the different energies supplied to the said patch vide said transducers; and at least one layer/compartment configured for either collection of extracted fluids and/or delivering at least one reagent formulation that detects the body analyte on activation and a method for performing transdermal extraction and detection of body fluids using said electronic patch.

Abstract: The apparatus for evaluating biological function of the present invention has living body probes 1, a behavioral information measuring part 2 and an apparatus body 3, and it utilizes near-infrared spectroscopy to evaluate biological function; apparatus body 3 has a controller 8 for calculating (based on light information from living body probes 1) a variety of parameters derived from two-dimensional diagrams showing relationships between changes in oxyhemoglobin and changes in deoxyhemoglobin and two-dimensional diagrams showing relationships between absolute amounts of oxyhemoglobin and absolute amounts of deoxyhemoglobin, a behavioral information input part for entering behavioral information measured by means of behavioral information measuring part 12, and a display part 10 for performing various types of image displays based on various parameters calculated by means of controller 8 and/or behavioral information entered in the behavioral information input part.

Abstract: A spectroscopic system for determining a property of a fluid flowing through a volume of interest underneath the surface of the skin of a patient is described. The spectroscopic system comprises: a probe head having an objective for directing an excitation beam into the volume of interest and for collecting return radiation from the volume of interest; a base station having a spectroscopic analysis unit and a power supply; and a cable connecting the probe head and the base station for transmission of the return radiation from the probe head to the base station and for providing the probe head with power from the power supply of the base station.

Abstract: A sensor assembly and/or systems for bioimpedance measurements may provide information related to the lean body water of the patient's tissue. The information related to the patient's lean body water may be determined by spectroscopic methods for determining water fraction. The patient's fat-free hydration levels may be incorporated into determinations of physiological parameters that may be determined by bioimpedance, such as cardiac output, hemtocrit, or body fat percentage.

Abstract: A method includes directing toward a portion of a subject's body a first pulse of electromagnetic energy. While the portion is in a functional state due to the first pulse, a second pulse is directed toward the portion. At a second-pulse time, reflected energy due to the second pulse is detected. While the portion is in a functional state due to the first and second pulses, a third pulse is directed toward the portion. At a third-pulse time, energy of the third pulse, reflected from the portion, is detected. In response to detecting the pulses at the second-pulse time and the third-pulse time, a characteristic of the portion is quantified resulting from (a) the functional state due to the first pulse and (b) the functional state due to the first and second pulses. A clinical state of the subject is identified. Other embodiments are described.

Abstract: In optical tomography, a calibration of the data may be necessary for image reconstruction. According to an exemplary embodiment of the present invention, the object of interest is used for calibration, wherein the image data is acquired during a highly oxygenated phase of the object of interest and wherein the calibration data is acquired during a low oxygenated phase of the object of interest. This may provide for an improved calibration, resulting in improved image quality.

Abstract: A biological observation apparatus according to an aspect of the present invention includes a sound wave radiating unit that radiates a sound wave into an object to be examined, a light radiating unit that radiates first light having a predetermined wavelength and second light different from the first light into a portion of the object influenced by the sound wave, a detector that detects reflected light of the first light and reflected light of the second light, and a calculation unit that calculates characteristic information of the object based on the reflected light of the first light and the reflected light of the second light.

Abstract: A monitoring system that may include an emission feature capable of emitting light into tissue, a modulator capable of modulating the emitter at a modulation frequency generally in a range of about 50 MHz to 3.0 GHz to generate resolvable photon density waves, a detection feature capable of detecting photons of the photon density waves after passage through the tissue and capable of providing a distribution of detected photons over a time period for the photon density waves, and a processor capable of calculating a skewness of the distribution and making determinations relating to a value of a physiologic parameter of the tissue based at least in part on the skewness of the distribution.

Abstract: Embodiments of the present system and methods measure a concentration of a substance, such as glucose, in a body. The present embodiments measure a first amount of infrared (IR) radiation absorbed or emitted from the body in a first wavelength band, and a second amount of IR radiation absorbed or emitted from the body in a second wavelength band. The present embodiments also measure a temperature at a surface of the body and an ambient temperature. A normalized ratio parameter is calculated from the four measurements, and the concentration of the substance in the body is calculated by correlating the normalized ratio parameter with the body surface temperature and the ambient temperature using an empirically derived lookup table. Also disclosed are methods for creating the empirically derived lookup table.

Abstract: A measuring apparatus, a physiological sensor, and an interface unit for determining blood parameters of a subject are disclosed. The sensor comprises an emitter unit comprising a first plurality of emitter elements configured to emit radiation at a second plurality of wavelengths and a detector unit configured to receive radiation generated by the emitter elements and transmitted through the tissue of the subject, wherein the detector unit is further configured to produce electric measurement signals indicative of absorption caused by the blood of the subject. The sensor or the interface unit is provided with a memory that stores emitter activation information for at least a third plurality of wavelengths, thereby to enable a monitoring unit operably connectable to the physiological sensor to employ a combination of wavelengths selected from the third plurality of wavelengths, wherein the third plurality is equal to or smaller than the second plurality.

Abstract: A secondary-emitter sensor position indicator has primary emitters that transmit light having primary wavelengths and at least one secondary emitter that transmits light having at least one secondary wavelength. A detector outputs a sensor signal in response to received light. An attachment assembly, in a sensor-on condition, positions the emitters and detector relative to a tissue site so that the sensor signal is substantially responsive to the primary wavelength light after attenuation by pulsatile blood flow within the tissue site and is negligibly responsive to the secondary wavelength light. The attachment assembly, in a sensor out-of-position condition, positions the secondary emitter relative to the tissue site so that the sensor signal is at least partially responsive to the secondary wavelength.

Abstract: To realize an imaging device, imaging method and program capable of improving image quality. This invention controls light sources so as to irradiate a body with irradiation light of a luminance level higher than that in the air arriving at the body, adjusts the imaging sensitivity of a solid imaging element for performing photoelectric conversion on pattern scattered light obtained through the inside of the body, and masks the luminance level deterioration region of a pattern image obtained from the solid imaging element to treat the masked image as an image to be composed with a reference image.

Abstract: The invention relates to a device for detecting and monitoring ingredients or properties of a measurement medium, for example physiological blood values, wherein said device contains a light source (20) for generating broad-spectrum measurement light (2) and for acting on a measurement area (3), and means (9) for fanning out the analysis light (4) reflected by the measurement area (3). The device also has a sensor array (11) for picking up the fanned light. The sensor array (11), the light source (20) and the means for dispersing the analysis light (4) are arranged as a compact unit in a housing.

Abstract: A sensor may be adapted to reduce motion artifacts by mitigating the effects of the tissue moving within the sensor. A sensor is provided with an elastomeric sensor body adapted to accommodate patient motion. Further, a sensor is provided in which the sensor cable is arranged to mitigate its pressure on a patient's tissue.

Abstract: A real-time simultaneous measurement apparatus includes: a hemoglobin information-receiving portion that sequentially receives hemoglobin information, which is information relating to the amount of hemoglobin in a head portion of a test subject, from a NIRS brain-measuring apparatus that receives a synchronization signal output by a synchronization signal output apparatus and acquires the hemoglobin information when the synchronization signal has been received; a brain wave information-receiving portion that sequentially receives the brain wave information of the test subject, from an EEG brain wave-measuring apparatus that receives a synchronization signal output by the synchronization signal output apparatus and acquires the brain wave information when the synchronization signal has been received; a synchronization processing portion that performs processing that synchronizes the hemoglobin information and the brain wave information; and an output portion that outputs the synchronized hemoglobin information

Abstract: A sensor is provided that is appropriate for optical detection of dissolved carbon dioxide. Such a sensor may be used for transcutaneous detection of carbon dioxide in the tissue. Alternatively, such sensors may be inserted into the tissue. Detection of dissolved carbon dioxide in the tissue may serve as a useful clinical marker for physicians.

Abstract: The present embodiments relate generally to patient monitoring system and, more particularly, to optical patient monitoring systems. In an embodiment, a physiological sensor includes a broadband emitter configured to emit two or more wavelengths of light into the tissue of a patient. The sensor also includes a charge coupled device (CCD) or complementary metal-oxide semiconductor (CMOS) photodetector array comprising a plurality of photodetectors. Each photodetector in the photodetector array is configured to receive the light from the tissue of the patient and to produce a corresponding output signal. Additionally, the sensor also includes one or more filter layers disposed on the plurality of photodetectors. The filter layers are configured to only allow light of particular wavelengths, polarizations, or both, to be received by each of the plurality of photodetectors.

Abstract: Method for the continuous measurement of the glucose concentration in blood undergoing pulsational flow, with the steps:—determination of a value for the glucose concentration for a first measurement cycle, and—repetition of the determination of this value in subsequent measurement cycles, where there is multiple detection, within each measurement cycle, of the transmittance and/or scattering power of the blood for at least two incident NIR wavelengths, calculation of an indicator value depending on the blood glucose concentration, and ascertaining the blood glucose concentration by comparing the indicator value with a previously determined calibration table, determination of the blood temperature during the detection of the transmittance and/or scattering power,—continuous measurement of the pulse duration of the pulsational blood flow, where the duration of the measurement cycle is arranged to keep in step as integral multiple of the pulse duration, where the first of the at least two NIR wavelengths is sel

Abstract: A system is provided that includes a monitor, a multiple configuration sensor having a first configuration and a second configuration, and a sensor connector. The sensor connector includes a first memory device and a second memory device, such that the first memory device is accessible by the monitor in the first sensor configuration and the second memory device is accessible by the monitor in the second sensor configuration. Another system is provided that includes a sensor adaptor having a processing circuit that reads a memory of a multiple configuration sensor and provides a first set of calibration data of a first sensor configuration and a second set of calibration data for a second sensor configuration.

Abstract: A physiological parameter tracking system has a reference parameter calculator configured to provide a reference parameter responsive to a physiological signal input. A physiological measurement output is a physiological parameter derived from the physiological signal input during a favorable condition and an estimate of the physiological parameter according to the reference parameter during an unfavorable condition.

Abstract: A physiological sensor is adapted to removably attach an emitter assembly and a detector assembly to a fingertip. The emitter assembly is adapted to transmit optical radiation having multiple wavelengths into fingertip tissue. The detector assembly is adapted to receive the optical radiation after attenuation by the fingertip tissue. The sensor has a first shell and a second shell hinged to the first shell. A spring is disposed between the shells and urges the shells together. An emitter pad is fixedly attached to the first shell and configured to retain the emitter assembly. A detector pad is fixedly attached to the second shell and configured to retain the detector assembly. A detector aperture is defined within the detector pad and adapted to pass optical radiation to the detector assembly. A contour is defined along the detector pad and generally shaped to conform to a fingertip positioned over the detector aperture.

Abstract: Methods, reports and systems for generating insulin resistance indexes for assessing decreased insulin sensitivity and/or levels of insulin resistance using a plurality of different measured lipoprotein particle parameters.

Abstract: Present embodiments are directed to a system and method capable of modulating light at a modulation frequency, wherein the modulation frequency is somewhere above about 50 MHz and below about 3 GHz, to generate photon density waves in a medium, detecting relative amplitude changes and phase shifts in the photon density waves, and detecting and graphically indicating a physiologic value related to scattering particles in the medium based on the phase shifts.

Abstract: Methods, apparatus, and systems for detecting hemozoin and diagnosing malaria infection are disclosed.

Abstract: The present invention discloses a PPG imaging device and a PPG measuring method. The PPG imaging device comprises a light emitting unit, a collimator unit, a beam splitter unit, an image sensing unit, and an image analysis unit. The light emitting unit provides an incident light signal. The collimator unit receives the incident light signal and transforms the incident light signal into a parallel light signal. The beam splitter unit receives the parallel light signal and reflects it to a tested region. The image sensing unit receives a reflected light signal reflected from the tested region and converts it into image signals. The image analysis unit connects with the image sensing unit and analyzes the image signals to obtain PPG signals of the tested region. The PPG imaging device may be arranged in an anti-light pollution unit, whereby to prevent from optical interference and obtain higher measurement precision.

Abstract: A wearable sensor may be provided. The wearable sensor may include a timing mechanism; a plurality of sensor pairs coupled to the timing mechanism wherein each sensor pair comprises an emitter and a detector; and a microcontroller coupled in communication to the timing mechanism and the plurality of sensor pairs.

Abstract: A pulse oximetry system adapted to obtain physiological data. The pulse oximetry system is adapted to store one or more digital audio files on one or more memory media in communication with a patient monitoring system. The pulse oximetry system is adapted to process the one or more digital audio files and to generate an audio signal in response to the physiological data.

Abstract: According to various embodiments, a medical system and method for determining tissue temperature may include a spectroscopic sensor. The spectroscopic sensors may be configured to provide information about changes in water absorption profiles at one or more absorption peaks. Such sensors may be incorporated into ablation systems for tissue ablation. Temperature information may be used to determine the scope, volume, and/or depth of the ablation.

Abstract: A sensor used to measure physiological characteristics of body tissues is provided. The physiological sensor includes a first light source assembly having a first light source in parallel with a second light source. Each of the first light source and the second light source have an anode and a cathode. A second light source assembly includes a third light source in parallel with a fourth light source. Each of the third light source and the fourth light source have an anode and a cathode. The anode of the first light source is electrically connected to the cathode of the second light source, the anode of said third light source, and the cathode of said fourth light source. The anode of the third light source is electrically connected to the cathode of the fourth light source.

Abstract: The present invention utilizes a plurality of spectroscopic systems and methods to measure characteristics of tissue useful in the diagnosis of disease. In a preferred embodiment, a combination of fluorescence, reflectance and light scattered spectra can be measured and processed to provide biochemical, architectural and morphological state of tissue. The methods and systems can be used particularly in the early detection of carcinoma within tissue in vivo and in vitro.

Abstract: A living body information measuring apparatus includes an optical system for irradiating light to a subject and detecting light from the subject, a signal processing portion for acquiring information with regard to a tissue condition of the subject based on a detecting signal of light, and a position determining portion for determining an acceptability of an irradiating position of light based on the detecting signal of light.

Abstract: Portable optical coherence tomography (OCT) devices including at least one mirror configured to scan at least two directions are provided. The portable OCT devices are configured to provide a portable interface to a sample that can be aligned to the sample without repositioning the sample. Related systems are also provided.