Abstract: Portable optical coherence tomography (OCT) devices including at least one mirror configured to scan at least two directions are provided. The portable OCT devices are configured to provide a portable interface to a sample that can be aligned to the sample without repositioning the sample. Related systems are also provided.

Abstract: A living body measuring instrument having a sub-mount on which plural light-emitting devices oscillating at different wavelengths are mounted in proximity, one optical output monitoring device that detects the optical outputs of these light-emitting devices and a light source mounted on the same heat sink which are housed in one can-package, a light-receiving device that detects a signal from a living body, and a circuit that separates the optical output signals from the light-emitting devices, wherein at least one light-emitting device has a light-emitting layer including a In1-xGaxAsyP1-y quantum well layer and a barrier layer on a GaAs substrate, the strain ? satisfies 0.4%???1.4%, wherein y in the composition satisfies 0.10?y?0.45, and the wavelength of the emitted light is from 700 nm to 760 nm.

Abstract: A method of computing peak spectral irradiance, the method comprising characterizing at least one light source to determine an irradiance distribution pattern, generating multiple density cones in a three dimensional model based on the irradiance distribution pattern, positioning the multiple density cones in a desired layout, measuring density of irradiance at one or more locations, and optimizing the positioning of the at least one light source to obtain a desired irradiance distribution.

Abstract: A system (1) for determining blood component concentration in vivo, the system (1) comprising: a probe (3) having an optical component and an electrical component, said optical component comprising a light source (9) for illuminating tissue (5) of a subject, said tissue (5) including a light absorbing blood component of interest, and a light detector (11) configured to detect light that has been emitted by said source (9) and has passed through said tissue (5); said electrical component comprising electrodes (13, 15) for applying an electric field across said tissue (5); and a control module (4) configured to receive signals from said light detector (11) that are representative of the intensity of light detected by the detector (11) and to receive signals from said electrodes (13, 15) that are representative of the capacitance of said tissue (5); wherein the amplitude of said signals varies periodically with the subject's cardiac cycle, and said control module (4) comprises a processor (35) operable to determ

Abstract: There are many inventions described and illustrated herein. In one aspect, the present invention is a system, a device and a method for sensing the concentration of an analyte in a fluid (for example, a fluid sample) or matrix. The analyte may be glucose or other chemical of interest. The fluid or matrix may be, for example, the fluid or matrix in the body of an animal (for example, human), or any other suitable fluid or matrix in which it is desired to know the concentration of an analyte. In one embodiment, the invention is a system and/or device that includes one or more layers having a plurality of analyte-equivalents and mobile or fixed receptor molecules with specific binding sites for the analyte-equivalents and analytes under analysis (for example, glucose). The receptor molecules, when exposed to or in the presence of analyte (that resides, for example, in a fluid in an animal), bind with the analyte (or vice versa).

Abstract: A probe which allows optical fiber fixing tools to be distributed substantially uniformly and symmetrically longitudinally or laterally and is easily fitted, even when a head part size of a subject changes is provided. A plurality of optical fiber fixing tools which fix incident optical fibers and detection optical fibers are arranged on a fixing part in a substantially straight line shape, a plurality of the fixing parts are included, the fixing parts are arranged so that its straight line direction is oriented in a substantially parietal direction, the optical fiber fixing tool on the fixing part and the optical fiber fixing tool on the adjacent different fixing part are connected by a connecting member, and the connecting member is made rotatable around the optical fiber fixing tool, whereby the probe can be fitted so that the optical fibers are arranged substantially symmetrically and uniformly longitudinally or laterally.

Abstract: A method for visualizing data includes the step of providing a virtual flight visualization of image data representing a non-landscape object.

Abstract: Methods and systems for providing data communication in medical systems are disclosed.

Abstract: An isolation system with imaging or radiation therapy capability is disclosed. At least one containment barrier (14, 15, 16, 17) defines an isolation region (10). An imaging or therapy system (20) is disposed outside of the isolation region. The containment barrier includes a substantially hollow tubular extension (24, 42, 44, 124, 224, 324) protruding away from the isolation region (10). The substantially hollow tubular extension surrounds an interior volume (26) that is in fluid communication with the isolation region and is in fluid isolation from the imaging or therapy system. The substantially hollow tubular extension is made at least partially of a material providing operative communication between the imaging or therapy system and the interior volume of the substantially hollow tubular extension.

Abstract: Medical devices and techniques derive breath rate, breath distention, and pulse distention measurements of a subject from a pulse oximeter system coupled to a subject. These parameters, together with the conventional physiologic parameters obtained from a pulse oximeter system, can be used to assist in controlling the ventilation levels and the anesthesia levels of the subject. The development has human applications and particular applications for animal research.

Abstract: The invention provides an enhanced method and system for non-invasive analysis of a target. The enhancement includes increased analytic power derived from creating a complete representation of a target using less than complete information. The invention provides a non-invasive analysis system and method that includes generating and exploiting a system model that includes a target model that accurately represents the interaction of radiant energy with a target. In a preferred embodiment according to the invention, a digital signal processor compares signals acquired from an actual non-invasive system with theoretical signals generated using the system model, identifies the target model that matches most closely, and outputs target characteristics, including target attribute of interest.

Abstract: A metabolite concentration is measured in vivo using Raman spectroscopy in such a way as to receive at a detector (229) light scattered from the metabolite in interstitial fluid in skin in a measurement location (217) at a depth (218) of from 200-300 ?m below the skin surface providing improved retention of correct calibration and transferability of calibration between individual subjects.

Abstract: A device and method of acquiring image data from a turbid medium using a diffuse optical tomography device including irradiating the turbid medium at a plurality of first spatial positions, collecting light emanating from the turbid medium at a plurality of second spatial positions, splitting the light collected from each second spatial position into at least two optical channels, measuring the intensity of the split light in each optical channel of the at least two optical channels using photo detectors, and reconstructing an image of the turbid medium from the measured intensities.

Abstract: Wearable or implantable devices combining microfluidic control of sample and reagent flow and micro-cavity surface plasmon resonance sensors functionalized with surface treatments or coatings capable of specifically binding to target analytes, ligands, or molecules in a bodily fluid are provided. The devices can be used to determine the presence and concentration of target analytes in the bodily fluids and thereby help diagnose, monitor or detect changes in disease conditions.

Abstract: A ceramic emitter substrate has a substrate body with top and bottom sides and a cavity disposed on the top side. Bonding pads are disposed within the cavity and solder pads are disposed on the bottom side. Light emitting diodes (LEDs) are electrically connected to the bonding pads. Low-resistance conductors are disposed within the ceramic substrate body so as to interconnect the bonding pads and the solder pads. The interconnect is configured so that the LEDs can be individually activated as an array via row and column drive signals applied to the solder pads.

Abstract: A highly miniaturized biosensor and a sensor unit, which can meet a demand for further miniaturization. With this invention, miniaturization is possible, and the number of production steps including those for assembling individual parts can be reduced. Accordingly, mass production will be possible, and cost reduction and high reliability will be achieved. A light emitting unit (21) and a light receiving unit (22) are disposed in a same recess (24) formed on a surface of a semiconductor substrate (23), and a light shielding cover substrate (27) having a first light guide section (25) and a second light guide section (26) is disposed on an upper side of the semiconductor substrate (23).

Abstract: A sensor may be adapted to provide output to indicate when the sensor experiences abnormal forces or pressure. The forces may be outside forces, or the forces may be generated by patient motion. A sensor system as provided may also be adapted to correct for such forces when calculating measurements related to a physiological characteristic.

Abstract: In an embodiment, a sensor may be adapted to provide information related to its position on a patient's tissue. postioned adjacenta sensor may be provided with tissue contact sensors which may relay a signal related to the proper placement of the sensor relative to the tissue of a patient. Such a sensor may be useful for providing information to a clinician regarding the location of the sensor in relation to the skin of a patient in order to provide improved measurements.

Abstract: An oximeter has a housing configured to have a cavity defining portion that is adapted to be fitted with covers of various dimensions to effect receptacles of different dimensions for accommodating differently sized sensor of sensor assemblies that are matable to the oximeter for sensing physical attributes of a patient. Each of the covers, once fully fitted to the housing, is fixedly latched thereto unless a force that overcomes the latching is applied to remove the cover. The effected receptacle is adapted to biasedly retain a corresponding sensor placed therein. The holstered sensor therefore would not accidentally fall out or be removed from the receptacle, until the user deliberately applies a force to remove the sensor from the receptacle.

Abstract: Embodiments disclosed may include a sensor which may be adapted to provide information related to its position on a patient's tissue. A sensor may be provided with tissue contact sensors which may relay a signal related to the sensor's proper placement adjacent a patient's tissue. Such a sensor may be useful for providing information to a clinician about the status of a sensor, such as if a sensor may be located more closely to the tissue in order to provide improved measurements.

Abstract: A method and apparatus for noninvasive measurement of a human body component, such as glucose, in vivo, include near infrared spectroscopy based laser sources driven at a carrier frequency lying within the characteristic absorption of the component. The apparatus also drives the laser diodes with a modulation frequency to generate a frequency difference between the measuring light and reference beam, and the interference of the two beams results in a beat frequency signal, which frequency is proportional to the optical path difference between the measuring light and the reference beam. The scattering lights from human tissue with different optical lengths are simultaneously detected and selected based on the beat frequency. The method is a convenient embodiment of the floating reference principle, which takes advantage of optical length selection.

Abstract: A method is provided for determining the location of the sensor. The method comprises determining a physiological parameter based on detected light and determining the location of the sensor based on the physiological parameter. In addition, a method is provided for operating a sensor that includes calibrating a sensor based on a patient-specific physiological parameter, in which the patient-specific physiological parameter is skin color, age, gender, pooled blood, venous blood pulsation, or abnormal tissue.

Abstract: A method is provided for determining contact of a sensor with a patient's tissue. The method comprises comparing the intensity of detected light at a first wavelength to a threshold, wherein the first wavelength is not used to determine a physiological characteristic of the patient, and determining if the sensor is in contact with the patient's tissue based on the comparison. In addition, a method is provided for determining the amount of light shunting during operation of the sensor. The method comprises comparing the intensity of detected light at a first wavelength to a threshold, wherein the first wavelength is not used to determine a physiological characteristic of the patient, and determining the amount of light shunting based on the comparison.

Abstract: An implantable device for measuring biological information of a body is provided, wherein the implantable device includes a receiver for receiving electromagnetic energy and converting the electromagnetic energy into electrical energy; a storage capacitor associated with the receiver such that the electrical energy from the receiver is stored in the storage capacitor; a biological sensor; a processing device; and a transmitter, wherein the biological sensor, processing device and transmitter are configured to receive electrical energy from the storage capacitor, and wherein the biological sensor, processing device and transmitter are configured such that when the receiver is receiving electromagnetic energy, the biological sensor, processing device and transmitter are inactive and when the receiver is not receiving electromagnetic energy, the biological sensor, processing device and transmitter are inactive.

Abstract: Optical sensor devices, image processing devices, methods and computer readable code computer-readable storage media for detecting biophysical parameters, chemical concentrations, chemical saturations, vital signs and physiological information such as a malignant condition are provided. The optical sensor includes an array of photodetectors, where each photodetector is configured to detect a spectrum of light. Exemplary physiological parameters include but are not limited to a pulse rate, a biophysical or physiological property of skin, a cardiovascular property, a property related to an organ such as the liver or the kidneys, and a temperature fluctuation. Alternatively one or more parameters are detected from a food item such as food tissue, a consumable beverage such as an alcoholic beverage, a dairy product, wine, a baked good, a fruit and a vegetable.

Abstract: An object of the present invention is to provide a noninvasive constituent concentration measuring apparatus and constituent concentration measuring apparatus controlling method, in which accurate measurement can be performed by superimposing two photoacoustic signals having the same frequency and reverse phases to nullify the effect from the other constituent occupying large part of the object to be measured. The constituent concentration measuring apparatus according to the invention includes light generating means for generating two light beams having different wavelengths, modulation means for electrically intensity-modulating each of the two light beams having different wavelengths using signals having the same frequency and reverse phases, light outgoing means for outputting the two intensity-modulated light beams having different wavelengths toward a test subject, and acoustic wave detection means for detecting an acoustic wave generated in the test subject by the outputted light.

Abstract: The invention relates to a peritoneal dialysis sampling system to be used together with a peritoneal dialysis system which is programmed to deliver fluid to a peritoneal cavity of a patient and to drain the fluid from the cavity, said peritoneal dialysis system comprising a supplying line and supplying means for supplying dialysis fluid to the peritoneal cavity, a draining line and draining means for draining the fluid from the cavity, said peritoneal dialysis sampling system comprising an automatic sampling system which is able to automatically sample volumic fractions of the dialysate contained in the peritoneum of the patient at specific time intervals in order to evaluate the peritoneal membrane characteristics and/or improve the peritoneal dialysis for a given patient.

Abstract: The disclosure provides an electromagnetic (EM) sensor system and method that permits rapid and non-invasive measurement of blood glucose or other biological characteristics that exhibits a unique spectral signature, such as its complex electrical permittivity within the frequency range from near DC to microwave frequencies. Low-level EM signals are coupled through the skin and modified by electrical properties of the sub dermal tissues. These tissues essentially integrate with the sensor circuit as they interact with the transmitted EM energy. The guided-wave signal can be sampled and converted to a digital representation. The digital information can be processed and analyzed to determine the frequency-sensitive permittivity of the tissues and a determination of blood glucose level is made based upon the sensor output. The sensor design and method has wide-ranging applicability to a number of important measurement problems in industry, biology, medicine, and chemistry, among others.

Abstract: A system for continuous in vivo biosensing of specific analyte molecule concentrations based on the dynamic optical properties of electronic polymers is disclosed. The biosensor system includes at least one implant member subcutaneously exposed to the interstitial fluid of the subject, and a reader member at least temporarily positioned over the implant member to probe it with light of specific wavelengths through the skin. The system has many potential applications, including the real-time monitoring of blood glucose levels in diabetics as a method to supplement or replace conventional capillary blood testing.

Abstract: A simple noninvasive technique that is capable of very accurate and fast blood analyte, e.g., glucose, level monitoring is provided. Fluctuation in the levels of glucose and other analytes affect the refractive index of blood and extra cellular fluid in biological tissue. Given that the propagation speed of light through a medium depends on its refractive index, continuous monitoring of analyte levels in tissue is achieved by measuring characteristics of the tissue that can be correlated to the refractive index of the tissue. For instance, the frequency or number of optical pulse circulations that are transmitted through an individual's tissue of known thickness within a certain time period can be correlated to an individual's blood glucose level.

Abstract: A method, system, and apparatus of a medical device powered by deliberate human motion for limited use are disclosed. In one embodiment, a medical device includes a motion module to sense whether a deliberate human motion is convertible to an electric current to power the medical device, a power module to convert the deliberate human motion to a limited use electric current that enables the medical device to operate during a limited cycle of time, and an energy storage module to store the limited use electric current converted from the deliberate human motion. The medical device may include a power sensing module to determine whether a threshold amount of energy has been generated. The medical device may also include a sensor of the motion module to sense whether the deliberate human motion is convertible to the limited use electric current by permitting a physical object to oscillate.

Abstract: A physiologic sensor device configured to be placed on an appendage. The sensor device includes a foldable portion designed to be deformed around the tip of the appendage. In some embodiments the foldable portion is a soft compressible material. In other embodiments a stabilization component is provided to isolate sensing elements from external forces. Some embodiments also include a deformable frame that folds in response to a bending force as the sensing device is placed on the appendage. The deformable frame holds the sensor device in place until another bending force is applied. In other embodiments the frame and/or sensor elements are removable and disposable relative to other components of the sensor device.

Abstract: A method and apparatus for non-invasive measurement of living body information comprises a light source configured to generate light containing a specific wavelength component, an irradiation unit configured to irradiate a subject with the light, and at least one acoustic signal detection unit including piezoelectric devices formed of a piezoelectric single crystal containing lead titanate and configured to detect an acoustic signal which is generated due to the energy of the irradiation light absorbed by a specific substance present in or on a subject.

Abstract: A sensor interface configured to adapt analog and digital sensors is disclosed herein. The sensor interface unit includes: a port configured to be coupled to either a digital sensor or an analog sensor and a signal processing circuit for processing an analog sensor output when an analog sensor is coupled to the port. The interface further includes a switching mechanism configured to bypass the signal processing circuitry when a digital sensor is coupled to the port.

Abstract: An implantable product such as an article, device, or system can include analyte and non-analyte containers in parts that can be operated as optical cavities. The product can also include fluidic components such as filter assemblies that control transfer of objects that affect or shift spectrum features or characteristics such as by shifting transmission mode peaks or reflection mode valleys, shifting phase, reducing maxima or contrast, or increasing intermediate intensity width such as full width half maximum (FWHM). Analyte, e.g. glucose molecules, can be predominantly included in a set of objects that transfer more rapidly into the analyte container than other objects, and can have a negligible or zero rate of transfer into the non-analyte container; objects that transfer more rapidly into the non-analyte container can include objects smaller than the analyte or molecules of a set of selected types, including, e.g., sodium chloride.

Abstract: An implantable system includes light sources to transmit toward vascularized tissue, in a time multiplexed manner, light having a first wavelength of approximately 660 nm, light having a second wavelength of approximately 810 nm, light having a third wavelength of approximately 910 nm, and light having a fourth wavelength of approximately 980 nm. The system includes one or more light detector to detect light of the first, second, third and fourth wavelengths scattered by vascularized tissue. Additionally, one or more processor is configured to determine levels of blood oxygen saturation based on the detected scattered light of the first and third wavelengths, determine levels of tissue oxygen saturation based on the detected scattered light of the first and third wavelengths, determine levels of hemoglobin concentration based on the detected scattered light of the second wavelength, and determine levels of tissue hydration based on the detected scattered light of the second and fourth wavelengths.

Abstract: Multi-wavelength optical apparatus includes an optical emitter, and an energy transition layer positioned adjacent to the optical emitter. The energy transition layer generates multi-wavelength electromagnetic radiation when monochromatic light from the optical emitter passes therethrough. The energy transition layer includes a plurality of luminescent films, and each film is configured to luminesce at a respective different wavelength range when monochromatic light from the optical emitter passes therethrough. The plurality of luminescent films may be arranged in contacting face-to-face relationship or may be arranged in an array. The luminescent films may include rare-earth doped oxides, phosphors, metal-doped oxides, rare-earth doped nitrides, nanostructures, and/or nanostructured films, etc. The optical emitter may be a light emitting diode (LED), a laser diode (LD), an organic light-emitting diode (OLED), a resonant cavity light emitting diode (RCLED), and/or an edge-emitting diode (EELED).

Abstract: An active pulse blood constituent monitor is disclosed. A sensor configured to provide an artificial excitation to a portion of the patient at a known frequency provides additional information in determining the physiological condition of the patient.

Abstract: Arrangements for the detection of the presence and/or concentration of an analyte in a sample of bodily fluid include diffuse transmission, diffuse reflection and edge or waveguide illumination arrangements. A vertical flow assay arrangement and/or technique is also disclosed, and includes a detection component that can be in the form of an array of optical detection elements. A number of assay pad constructions are described which may include at least one or more of the following components: a prefilter component, a reflective component, a membrane component, a reagent component, a mesh component, and a component to prevent lateral spreading.

Abstract: In a medical pulse oximetry sensor (10) at least two light emitting diodes (16, 18) are disposed to emit red light and infrared light through a portion of a subject's anatomy with a typically high oxygenated blood throughput. Typically, this area is also relatively narrow, to allow the light to pass through the area with acceptable attenuation, such as a finger or an earlobe. Light emitted from the LEDs (16, 18) is incumbent upon an integrated circuit (22) printed from a single CMOS substrate (21). The integrated circuit (22) includes all preprocessing and post-processing elements needed to convert the detected light signals into a pulse oximetry measurement. These elements include a photodetector (20), a photo pre-amplifier (40), a sampler/holder (42), an analog to digital converter (44), a microprocessor (46) a rangefinder (48), a timing control circuit (50) and an LED control circuit (52).

Abstract: A patient cable has a duo sensor connector having a first socket section and a second socket section. The first socket section is configured to removably attach a two-wavelength sensor. The second socket section in conjunction with the first socket section is configured to removably attach a multiple wavelength sensor in lieu of the two-wavelength sensor. A circuit housed in the duo sensor connector converts emitter array drive signals adapted for the multiple wavelength sensor into back-to-back emitter drive signals adapted for the two-wavelength sensor when attached.

Abstract: A system for visualizing needle entry into a body is presented. The system includes a needle for entering a body. The needle is coated with a radiation scattering coating on at least a portion of the needle. The system additionally includes a radiation visualization device which detects reflected radiation directed at a target body and enables medical personnel to view anatomical structures such as a blood vessel along with the inserted needle within a body.

Abstract: A capsule casing of a capsule medical device has a chemical sensor inside, used for sensing operation. The chemical sensor has a recovery device which resets the chemical sensor to an initial state thereof so as to use the chemical sensor for the sensing operation a plurality of times or continuously.

Abstract: A process is provided for analyzing a specimen of biological material in any of a number of biochemical or immunological tests for an analyte which involves subjecting the specimen to treatment which develops a color correlating to the amount of analyte in the specimen. According to the invention at least one defined color characteristic selected from hue angle, chroma, saturation and lightness of the developed color is measured and the results of that measurement analyzed to determine the presence or concentration of the analyte in the specimen. Particular applications are to the detection of cancerous or pre-cancerous abnormalities from the analysis of lung mucus, throat mucus, cervical mucus or seminal fluid.

Abstract: The present invention is related generally to measurement of body fluid volumes in an animal subject. The body fluid volumes of interest include extracellular fluid volume (ECFV), total vascular plasma volume (TVPV) and interstitial fluid volume (IFV). The methods are especially beneficial for subjects suffering from renal failure and particularly those undergoing renal dialysis. ECFV can be measured by administering a first molecule which is non-metabolized and permeable to vessel walls of the vascular system wherein the first molecule is distributed within the total vascular space as well as the interstitial space. TVPV can be measured by administering a second molecule which is non-metabolized and impermeable to vessel walls of the vascular system wherein the second molecule is distributed within only the vascular space. IFV can then be calculated using the equation IFV=ECFV?TVPV.

Abstract: Apparatus for measuring blood parameters such as chromophore, for example haemoglobin, concentration and blood flow detects light scattered from tissue surface (20) with a multispectral detector (24) that is sensitive to light across a range of different wavelengths. Algorithms are described that demonstrate extraction of chromophore information from scattered light occupying two, red and green or blue, or three bands of the visible spectrum. Simultaneous extraction of blood flow information from scattered laser light occupying either the same or a distinct spectral band is also described.

Abstract: A method for diagnosing pulmonary hypertension from phase-contrast magnetic resonance (MR) images includes providing a time series of one or more magnetic resonance (MR) flow images of a patient's mediastinum during one or more cardiac cycles, segmenting the pulmonary artery within each image of the times series of images, identifying the anterior wall and pulmonary valve within the segmented pulmonary artery, analyzing blood flow during a diastolic phase of the one or more cardiac cycles to determine a relative duration of blood flow, tstreamlines, during the diastolic phase, analyzing blood flow during a latter portion of a systolic phase and a subsequent diastolic phase of the one or more cardiac cycles to detect the presence and duration tvortex of a vortex, and diagnosing the presence of pulmonary hypertension from tstreamlines and tvortex.

Abstract: An apparatus for determining a spectral ratio between a first signal having a first spectrum which depends on a biological quantity, and a second signal having a second spectrum which depends on a biological quantity, the first signal and the second signal having a plurality of harmonics of a periodic signal, the apparatus including a computer for computing a first wave ratio between a spectral value of the first spectrum which has a frequency of a harmonic of the plurality of harmonics, and a spectral value of the second spectrum which has the frequency of the harmonic; and for computing a second wave ratio between a spectral value of the first spectrum which has a frequency of another harmonic of the plurality of harmonics, and a spectral value of the second spectrum which has the frequency of the other harmonic. In addition, the apparatus includes an optimizer.

Abstract: A device, system and method of in-vivo analysis. An in-vivo device may include a chromatography unit to interact in-vivo with a body lumen substance, and a sensor to sense in-vivo a property of the chromatography unit.

Abstract: Pulse oximeter apparatus and method comprising a reusable pulse oximeter probe and a disposable bandage. The bandage has receptacles for receiving and aligning the oximeter's light emitting diode and photocell detector.