Abstract: This invention provides a non-invasive diagnosis system that is not only capable of producing high-resolution, three-dimensional images of abnormalities of tissue growth inside the body but, it can also detect the type of abnormalities and their location using multispectral imaging techniques. It is possible to provide a portable, non-invasive device that is handheld and with which a person may use to screen themselves for early detection of skin cancer without the need to visit a physician. As the present invention uses broadband sources and/or multiple coherent sources, secondary factors such as oxygen metabolism or blood volume associated with the cancer tissues could also be detected to provide further verification of the type. This invention would raise the accuracy of diagnosis and reduce the rate of false positives and false negatives.

Abstract: A biological information measuring apparatus, a method of acquiring biological information, and a biological information measuring band are provided. The biological information measuring apparatus may emit light beams in a direction, which is actively or passively adjusted, to a region of interest inside a target object, detect the light beams returning from the target object along trajectories different from one another, and select an optimum light beam among the detected light beams.

Abstract: Devices and methods of detecting gas and volatile organic compounds from skin are disclosed. One system for detecting emissions through skin includes a sensing device having a housing having a top portion and a bottom portion, the bottom portion having a concave-shaped bottom surface creating a cavity region, the at least one light source arranged to emit a spectral range of wavelengths of light into the cavity region, and at least one sensor disposed to receive light emitted by the at least one sensor after the light propagates through at least a portion of the cavity region, the at least one sensor configured to generate a signal based on the received light. The sensing device may also include a communication module configured wirelessly transmit the spectral information to a mobile device for determining a characteristic, for example, a blood glucose level.

Abstract: In a surgical drain system formed with two or more branches, exudate flow from a patient's wound is directed between two branches with the respective filling and emptying times determined in order to identify the presence of a blockage in the drain.

Abstract: Disclosed herein are systems, methods, and devices for calibrating contrast measurements from laser speckle imaging systems to accurately determine unknown particle motion characteristics, such as flow rate. The calibration stores to memory calibration data, which may include a set of measurements from samples with known particle characteristics and/or estimates of noise, including the effects on contrast arising from undesired signals unrelated to the unknown particle motion characteristics. The calibration data may be accessed and used to correct an empirical measurement of contrast and/or interpolate a value of the unknown particle motion characteristic. The system may include a light source, photodetector, processor, and memory, which can be combined into a single device, such as a wearable device, for providing calibrated flow measurements. The device may be used, for example, to measure blood flow, cardiac output, and heart rate, and can be used to amplify the pulsatile signal.

Abstract: Systems and methods for quantitatively imaging retinal blood vessel oxygen saturation using retinal auto-fluorescence (AF) are provided. One or more excitation sources can be used to provide light to the retina, and retinal AF can be detected by one or more detectors. The quantitative level of oxygen saturation in the blood can be determined based on the intensity of AF.

Abstract: A method of estimating an optical physical property value distribution includes: first estimating including reading a first measured value obtained by measuring isotropic backscattering light of light that is applied to a measurement subject, from a storage and estimating a first optical physical property value distribution that is an optical physical property value distribution in the measurement subject, by an inverse analysis arithmetic operation; and second estimating including reading a second measured value obtained by measuring more anisotropic backscattering light of light that is applied to the measurement subject than the backscattering light corresponding to the first measured value, from a storage and estimating a second optical physical property value distribution that is an optical physical property value distribution in the measurement subject, by an inverse analysis arithmetic operation using at least part of the first optical physical property value distribution as an initial value.

Abstract: A spectrometer according to one aspect may include a plurality of light sources configured to emit light to a target object, a plurality of wavelength controllers installed on one surface of each of the plurality of light sources and configured to adjust a peak wavelength band of each of the light sources, and a detection unit configured to detect light returning from the target object.

Abstract: A biosensor identifies a blood type using photoplethysmography (PPG) technology. A PPG circuit obtains a plurality of spectral responses at a plurality of wavelengths detected from skin of a user. A processing circuit determines a blood factor indicator using the plurality of spectral responses. The blood factor indicator may include a signal quality parameter or a ratio R value. A calibration database includes a correlation of the blood factor indicator to a plurality of blood types. The blood type of the user is identified using the blood factor indicator and the calibration database.

Abstract: User equipment is configured to collect biosensor data from an integrated biosensor or by receiving biosensor data from one or more external biosensors. The user equipment includes a Health Monitoring (HM) application. The HM application is configured to receive the biosensor data and display the biosensor data on the display of the user equipment. The user equipment may also communicate biosensor data over a local or wide area network to a third party, such as a pharmacy or health care provider.

Abstract: The present invention is directed to a bio-fluid detector such as a hemoglobin detector having the capability of receiving, storing and transmitting health information utilizing a portable transmitter and receiver including electronic PDAs such as cell phones. Further, the present invention utilizes a non-invasive hemoglobin detector that is connected to a portable transmitter-receiver such as PDAs including, but not limited to, cell phones.

Abstract: Aspects of the subject disclosure may include, for example, a system or biological sensor configured to detect an adverse biological condition from a comparative measurement from two or more body parts. Other embodiments are disclosed.

Abstract: An apparatus and method for non-invasively determining a blood oxygen parameter value of a subject's tissue is provided. An embodiment of the method includes the steps of: a) providing a spectrophotometric sensor that includes a processing portion and a transducer, b) detecting at least a portion of transmitted light after passage through the subject's tissue and producing initial signal data from the detected light; and c) using the processing portion to: (i) determine a value representative of an attenuation of at least one wavelength of light detected; (ii) determine whether the representative attenuation value is outside a predefined range of attenuation values; and (iii) determine the blood oxygen parameter value using a first interrogation or an alternate interrogation setting.

Abstract: A method and system for measuring personal health, the method comprising detecting a photoplethysmograph (PPG) wave, the PPG wave generated based on a combination of infra-red and red lights, transmitting the PPG wave to a server, the server processing the PPG wave to infer biometric statistics based on machine learned correlations generated from a training set of PPG waves and biometric data, receiving the biometric statistics from the server, and generating display data based on the biometric statistics.

Abstract: The present disclosure relates to noninvasive methods, devices, and systems for measuring various blood constituents or analytes, such as glucose. In an embodiment, a light source comprises LEDs and super-luminescent LEDs. The light source emits light at at least wavelengths of about 1610 nm, about 1640 nm, and about 1665 nm. In an embodiment, the detector comprises a plurality of photodetectors arranged in a special geometry comprising one of a substantially linear substantially equal spaced geometry, a substantially linear substantially non-equal spaced geometry, and a substantially grid geometry.

Abstract: A bone oximeter probe includes an elongated member and a sensor head at an end of the elongated member to make measurements for a bone. The measurements can indicate the viability or nonviability of the bone. In an implementation, the probe is advanced through an incision in soft tissue, towards the underlying bone, and positioned so that the sensor head faces the bone to be measured. Optical signals are sent from the sensor head and into the bone. The bone reflects some of the optical signals which are then detected so that measurements for the bone can be made. Some of these measurements include an oxygen saturation level value, and a total hemoglobin concentration value of the bone.

Abstract: A bio-signal quality assessment apparatus, a bio-signal quality assessment method, a bio-signal measurement parameter optimization apparatus, and bio-signal measurement parameter optimization apparatus method are provided. The bio-signal quality assessment apparatus includes a processor configured to determine a moving average of a bio-signal, and assess a quality of the bio-signal, based on a comparison between the determined moving average and the bio-signal.

Abstract: A wearable device includes a housing with a window and an electronic module supported by the housing. The electronic module includes a photoplethysmography sensor, a motion sensor, and a signal processor that processes signals from the motion sensor and signals from the photoplethysmography sensor. The signal processor is configured to remove frequency bands from the photoplethysmography sensor signals that are outside of a range of interest using a band-pass filter to produce pre-conditioned signals, and to further process the pre-conditioned signals using the motion sensor signals to reduce motion artifacts from footsteps during subject running. The device includes non-air light transmissive material in optical communication with the photoplethysmography sensor and the window that serves as a light guide for the photoplethysmography sensor. The window optically exposes the photoplethysmography sensor to a body of a subject wearing the device via the non-air light transmissive material.

Abstract: A subdermal imaging system which may determine whether a person's body is in contact with a display, and perform a subdermal imaging process to determine subdermal characteristics by a photoacoustic imaging process. Ultrasonic emissions emitted from the photoacoustic process may be received with an ultrasonic receiver array. The subdermal imaging system may adjust the wavelength and/or intensity of the photoacoustic process in order to image desired subdermal features.

Abstract: The present invention provides a multi-section finger sleeve-type probe, which comprises a finger sleeve body, a flexible flat cable mounted on the finger sleeve body, a light emitting diode, a photo diode, and a wire electrically connected to the flexible flat cable. The finger sleeve body is a cylinder with an opening at the bottom thereof. Comparing with an existing finger sleeve-type probe in which wiring pipes are provided on both the left and right sides of a silicone sleeve and thus the silicone sleeve is flattened, the finger sleeve body fits the shape of a finger and fully wraps around the finger. While being used, the finger is inserted into the finger sleeve body and expands the periphery thereof, thus the finger is totally wrapped to provide a big resistance. The multi-section finger sleeve-type probe can be worn stably, be not easy to drop off, and be suitable for long term use.

Abstract: In accordance with particular implementations of the invention described herein, a sample for analysis is illuminated under each of one or more narrow-band light sources. The light incident upon this sample is received by a sensor that generates measurement data in response thereto. One or more processors are configured to receive the measurement data and derive an excitation response curve and a fluorescent response curve from the measurement data. The processor is further configured to generate a fluorescent profile value using measurements from the fluorescent response curve for each of the captured narrow band measurement data and an excitation profile value corresponding to the area under the fluorescence curve divided by the area under the excitation curve. The generated fluorescent profile and excitation profile are both output as a dataset providing improved measurement values over similar approaches in the art.

Abstract: The invention relates, inter alia, to an apparatus (10) for analyzing a material (101), comprising an excitation emission device (100) for generating at least one electromagnetic excitation beam (SA), in particular an exciting light beam, having at least one excitation wavelength, further comprising a detection device (106) for detecting a reaction signal (SR), and a device (107) for analyzing the material on the basis of the detected reaction signal (SR).

Abstract: A system and method for measuring an amount of blood and/or clotting in a pocket around an implantable device. The system may include a first light source configured to emit light over a first wavelength range. The system may include a first photodetector configured to output a first signal indicative of an amount of the first light received by the first photodetector. The system may include the implantable device and an external device. The implantable device may include one of the first light source and the first photodetector, and the external device may include the other of the first light source and the first photodetector. In some embodiments, the external device may include a controller configured to calculate the amount of blood/or clotting in the pocket around the implantable device using at least a measurement of the first signal.

Abstract: There is provided a device (200) that generates display data to be displayed by each of a plurality of head mounted displays (100A, 100B) configured to be worn by each of a plurality of users involved in a surgery based on information that the each of a plurality of users in the surgery visually recognizes.

Abstract: A device and method for measuring levels of individual lipids in a lipoprotein, the device being equipped with: an irradiation unit that can emit irradiation light having a first wavelength and irradiation light having a second wavelength at predetermined light intensities toward the inside of a living body from outside of the living body; a light intensity detection unit arranged at a predetermined distance apart from a position at which light is emitted from the irradiation unit or is arranged adjacent to the position, and can detect the intensities of first light and second light both emitted from the living body; a scattering coefficient calculation unit that can calculate a first scattering coefficient and a second scattering coefficient in the living body respectively on the basis of the intensities of a first light and a second light detected by the light intensity detection unit; and a lipid level calculation unit.

Abstract: The position detector disclosed may include: a diamond with nitrogen vacancy centers; an activator configured to activate the nitrogen vacancy centers in the diamond to emit fluorescence signals; a sensor configured to detect the fluorescence signals emitted from the diamond, and a controller configured to control components of the position detector. The controller may be configured to: control the activator to activate the nitrogen vacancy centers in the diamond; control a first EM radiation source to generate one or more EM signals; receive via the sensor one or more first indications of one or more first fluorescence signals; control a second EM radiation source to generate one or more EM signals; receive via the sensor one or more second indications of one or more second fluorescence signals; and calculate the position of the diamond based on the received indications. The position detector has utility in detecting a medical tool in the body of a subject, for example.

Abstract: According to the present disclosure, a method of calculating an angle of impact of a bloodstain is performed by a device for calculating an angle of impact of a bloodstain and includes obtaining a captured image of an analysis target by using a camera, extracting a spatter stain included in the analysis target, by analyzing the obtained captured image, calculating a major axis length and a minor axis length of the spatter stain, estimating an angle of impact of the spatter stain by using the major axis length and the minor axis length of the spatter stain, and outputting the spatter stain and the angle of impact of the spatter stain.

Abstract: A microelectromechanical device and method for neuroprosthetics comprises microactuators and microelectrodes. The microelectrodes are to be positioned in a nerve bundle and bonded with the microactuators through an interconnect. The position of each of the microactuators can be individually tuned through control signals so that the microelectrodes are implanted at desired positions in the nerve bundle. The control signals are transmitted to the microactuators and generated with a open-loop or closed-loop control scheme that uses signals acquired by the microelectrodes from the nerve bundle as feedback.

Abstract: A sensor, system, and method for detecting and correcting for changes to an analyte indicator of an analyte sensor. The analyte indicator may be configured to exhibit a first detectable property that varies in accordance with an analyte concentration and an extent to which the analyte indicator has degraded. The analyte sensor may also include a degradation indicator configured to exhibit a second detectable property that varies in accordance with an extent to which the degradation indicator has degraded. The analyte sensor may generate (i) an analyte measurement based on the first detectable property exhibited by the analyte indicator and (ii) a degradation measurement based on the second detectable property exhibited by the degradation indicator. The analyte sensor may be part of a system that also includes a transceiver. The transceiver may use the analyte and degradation measurements to calculate an analyte level.

Abstract: A device, a substrate including a connection port. The substrate includes traces to enable a circuit of the substrate. The circuit is connected to the connection port. A light sensor mechanically and electrically attached respectfully to a first planar surface of the substrate and the circuit. A light source is mechanically and electrically attached respectively to the first planar surface and the circuit. The light source is located lateral to the light sensor at a first distance. A light signal of the light source emanates from the light source at an angle perpendicular to the first planar surface and a reflector mechanically attached to the first planar surface and located between the light sensor and the light source. The light signal is substantially reflected by the reflector away from the light sensor.

Abstract: A device comprising a piece of planar substrate embedded with two sensors and two emitters. The substrate has a generally planar surface for application onto the wearer's body part. The emitters and sensors are shown to be arranged in such a way that no subset of any two emitters and one sensor, or subset of any two emitters and one sensor, forms a straight line, which prevents the two sensors from detecting the same noise caused by the same wearer movements.

Abstract: Methods for calculating a MetaKG signal are provided. The method including illuminating a region of interest in a sample with a near-infrared (NIR) light source and/or a visible light source; acquiring images of the region of interest; processing the acquired images to obtain metadata associated with the acquired images; and calculating the MetaKG signal from the metadata associated with the acquired images. Related systems and computer program products are also provided.

Abstract: Systems and methods are provided for determining the frequency of a cardiovascular pulse based on a first physiological signal that is continuously available and a second physiological signal that is less available and that is more accurate or otherwise improved relative to the first signal with respect to pulse rate estimation. When the second signal is available it controls the determination of the pulse rate. When the second signal is unavailable, the first signal is used to determine the pulse rate. This can include using the first signal to estimate the pulse rate until the second signal is available, at which point the pulse rate is estimated based on the second physiological signal. Alternatively, the first signal could be used to determine a number of candidate pulse rates, and the second signal could be used to select a pulse rate from the set of candidate pulse rates.

Abstract: Wrist-worn devices and related methods measure a pulse transit time non-invasively and calculate a blood pressure value using the pulse transit time. A wrist-worn device include a wrist-worn elongate band, at least four EKG or ICG electrodes coupled to the wrist-worn device for detecting a ventricular ejection of a heart, a photo-plethysmogram (PPG) sensor coupled to the wrist-worn device for detecting arrival of a blood pressure pulse at the user's wrist, and a controller configured to calculate a pulse transit time (PTT) for the blood pressure pulse. The controller calculates one or more blood pressure values for the user based on the PTT.

Abstract: A connectorized lighting system for a base structure such as a deck pad, comprising a base structure having an a retaining cavity disposed in and running along a surface of the base structure, a lighting element inserted into the retaining cavity, and connectorized light source that provides electrical power to the lighting element, exhibits a low profile, and may be removable and replaceable without tools. The base structure may be a deck pad on a boat or a covering for a floor, spa, spa cabinet, pool, or any other surface. The deck may comprise EVA or PE foam material, and may comprise one or more layers of sheet material. The retaining cavity may comprise a window and bevels for visibility. A lighting element may be held in place by forces created when the compressible material of the base structure is compressed by pressing the lighting element into the retaining cavity.

Abstract: A light-based method and technique for measuring the static and average plasma glucose concentration over a prolonged period of time. More specifically, the disclosure relates to a method that utilizes mathematical analysis of appendage mobile LED flash IR light transmittance, absorption and scattering by using high resolution mobile camera data to estimate the concentration of glucose and glycated hemoglobin (HbA1c) in millimoles per liter (mmol/L).

Abstract: A sensor that is capable of detecting a pulse of a user by using a proximity illumination sensor or a proximity sensor is provided. A proximity sensor (14) that includes a pulse detection function includes a count adjustment circuit (5) that performs adjustment such that a digital output value (ADCOUT1) from an analog-digital conversion circuit (4) changes in accordance with each value of a distance at least in a prescribed range of the distance between a photodiode (2) and a detected object (a finger in the drawing) and a digital filter (6) for detecting a cycle of the digital output value (ADCOUT1) from the analog-digital conversion circuit (4).

Abstract: A piece of medical information, e.g., a medical image of tissue, may be received for processing and analysis on a computing device or system. A region of the medical image may be analyzed to determine a presence of one or more contours in the region. One or more properties of the one or more contours may be extracted, where the one or more properties are inputted into a first algorithm to determine an indication of cancer for the region. The indication of cancer may be inputted into a second algorithm to generate a cancer score for the region.

Abstract: A physiological monitoring device controls an optical signal acquisition system within a number of discrete operating states, each providing values for controllable parameters such as illumination intensity for a light source and the gain for an optical detector. Using this technique, a small number of operating states may be defined, such as operating states that are known to work well within expected use scenarios. This approach advantageously facilitates optimal or near optimal operation across a range of most likely use cases while avoiding complex or continuous optimization problems. The list of operating states may further be prioritized so that a best operating state can be selected based on, e.g., signal quality or environmental conditions.

Abstract: Disclosed herein is a physiological measurement system that can automatically adjust the number of wavelengths used based on the quality of a sensor signal that is reflective of an optical radiation detected at a sensor after tissue attenuation. The signal quality is examined to determine if it is sufficient to support the use of a full set of wavelengths. If it is determined to be insufficient to support the full set, a reduced number of wavelengths is used.

Abstract: Reducing noise in a signal is provided. A first filter includes a selectively definable passband for filtering a first signal used in determining at least one patient parameter. A characteristic analyzer detects a characteristic of a second signal and generates a variability measurement value using a series of data values within the second signal over a previously occurring window of time. A filter controller coupled to the characteristic analyzer uses the variability measurement value to define a characteristic of the passband for the first filter and selectively tunes the passband of the first filter according to the defined characteristic. Related apparatus, systems, techniques, and articles are also described.

Abstract: Because reprocessing or refurbishing of physiological sensors reuses large portions of an existing sensor, the material costs for refurbishing sensors is significantly lower than the material costs for making an entirely new sensor. Typically, existing reprocessors replace only the adhesive portion of an adhesive physiological sensor and reuse the sensing components. However, re-using the sensing components can reduce the reliability of the refurbished sensor and/or reduce the number of sensors eligible for refurbishing due to out-of-specification sensor components. It is therefore desirable to provide a process for refurbishing physiological sensors that replaces the sensing components of the sensor. While sensing components are replaced, generally, sensor cable and/or patient monitor attachments are retained, resulting in cost savings over producing new sensors.

Abstract: An apparatus and method, the apparatus comprising; a light collector configured to collect ambient light and provide the collected light to a portion of skin of a user; a photodetector configured to enable a biometric parameter to be monitored by detecting changes in the light absorbed by the portion of skin; and an amplifier configured to amplify an output signal provided by the photodetector; wherein the light collector is configured to filter the collected ambient light to increase the proportion of light within a selected range of wavelengths which is provided to the portion of skin of the user relative to the collected ambient light.

Abstract: A surgical system includes at least one light emitter generating light at a first intensity and an array of light sensors including a least one row of light sensors, individual light sensors in the row of light sensors adapted to generate a signal including a non-pulsatile component. The system also includes a controller coupled to the array of light sensors, the controller including an analyzer to determine the magnitudes of the non-pulsatile components at the individual light sensors in the row of light sensors, to determine if the non-pulsatile component transitions from a higher magnitude to a lower magnitude and from a lower magnitude to a higher magnitude, and if so, to determine if the first intensity should be changed to a second intensity.

Abstract: Headphone ear tips are made with an outer surface that changes its coefficient of friction. The outer surface is coated with photochromic compound, hierarchical microstructures, fibers formed through electrostatic flocking, or a combination thereof.

Abstract: An apparatus for detecting biometric information of a living body detects a pulse wave and extracts the biometric information of the living body in a non-invasive method. The apparatus for detecting biometric information includes a surface pulse wave measurement unit for measuring a surface pulse wave of an object. The surface pulse wave measurement unit includes at least one light source that radiates incoherent light and at least one photodetector that measures an intensity of light radiated by the at least one light source and reflected from a surface of the object. The surface pulse wave measurement unit measures the surface pulse wave of the object based on a change in the intensity of the light reflected from the surface of the object.

Abstract: An apparatus and method for measuring a biological component are provided. The apparatus may include a spectrum data acquirer configured to acquire spectrum data of a user by emitting light to a skin of the user and detecting the light reflected from the skin, and a processor configured to extract a user characteristic signal from the acquired spectrum data using a background signal and a first unit component spectrum and generate a second unit component spectrum personalized to the user by updating the first unit component spectrum based on the user characteristic signal.

Abstract: The present disclosure generally relates to wearable devices and methods for measuring a photoplethysmographic (PPG) signal. The wearable devices and methods described herein are capable of obtaining PPG signals by employing a PPG sensor array configured to receive light at angles associated with a high perfusion index. Viewing components may be coupled to the PPG sensor array to effect transmission of light at these preferential angles.

Abstract: The present invention relates to a device (10) for obtaining and processing measurement readings including at least a component representative of a physical phenomenon in a living being (16), comprising a sensor (12) for obtaining measurement readings from at least one body part of a living being (16) from a distance having at least a component representative of the physical phenomenon in the living being (16), an identification unit (26) for identifying the at least one body part of the living being (16); an extraction unit (38) for extracting at least one first signal from the measurement readings representing at least one component representative of the physical phenomenon, an evaluation unit (30) for obtaining adjustment information according to the at least one identified body part, and an adjustment unit (34) for adjusting the at least one first signal according to the adjustment information and for generating at least one output signal representing the physical phenomenon of the living being (16).

Abstract: This relates to systems and methods for determining one or more of a user's physiological signals. The one or more of the user's physiological signals can be determined by measuring pulsatile blood volume changes. Motion artifacts included in the signals can be canceled or reduced by measuring non-pulsatile blood volume changes and adjusting the signal to account for the non-pulsatile blood information. Non-pulsatile blood volume changes can be measured using at least one set of light emitter-light sensor. The light emitter can be located in close proximity (e.g., less than or equal to 1 mm away) to the light sensor, thereby limiting light emitted by the light emitter to blood volume without interacting with one or more blood vessels and/or arterioles. In some examples, the systems can further include an accelerometer configured to measure the user's acceleration, and the acceleration signal can be additionally be used for compensating for motion artifacts.