Aromatic Acid Moiety Patents (Class 560/8)
  • Patent number: 6720445
    Abstract: Novel acetyloxymethyl esters are disclosed. Methods of treating an illness, including cancer, hemological disorders and inherited metabolic disorders, and treating or ameliorating other conditions using these compounds are also disclosed. The compounds are effective in the inhibition of histone deacetylase.
    Type: Grant
    Filed: December 21, 2000
    Date of Patent: April 13, 2004
    Assignee: Beacon Laboratories, Inc.
    Inventors: Hsuan-Yin Lan-Hargest, Norbert L. Wiech
  • Patent number: 6713645
    Abstract: A class of novel tricyclics is disclosed together with the use of such compounds for inhibiting sPLA2 mediated release of fatty acids for treatment of conditions such as septic shock.
    Type: Grant
    Filed: October 13, 2000
    Date of Patent: March 30, 2004
    Assignee: Eli Lilly and Company
    Inventors: Nicholas James Bach, Susan Elizabeth Draheim, Robert Delane Dillard, Edward David Mihelich, Jason Scott Sawyer, Douglas Wade Beight, Michael LeRoy Phillips, Tulio Suarez, Daniel Jon Sall, Jolie Anne Bastian, Michael Lyle Denney, Gary Alan Hite, Michael Dean Kinnick, Robert Theodore Vasileff, John Michael Morin, Jr., Ho-Shen Lin, Michael Enrico Richett, Richard Waltz Harper, John McNeill McGill, III, Benjamin Alan Anderson, Nancy Kay Harn, Richard James Loncharich, Richard Walter Schevitz
  • Publication number: 20040059124
    Abstract: Disclosed are novel colorant compounds which contain one or more ethylenically-unsaturated (vinyl), photopolymerizable radicals which may be copolymewrized (or cured) with ethylenically-unsaturated monomers to produce colored compositions such as colored acrylic coatings and polymers, e.g., coatings and polymers produced from acrylate and methacrylate esters, colored polystyrenes, and similar colored polymeric materials derived from other ethylenically-unsaturated monomers. The present invention also pertains to processes for the preparation of certain of the photopolymerizable colorant compounds.
    Type: Application
    Filed: September 3, 2003
    Publication date: March 25, 2004
    Inventors: Michael John Cyr, Max Allen Weaver, Gerry Foust Rhodes, Jason Clay Pearson, Phillip Michael Cook
  • Patent number: 6699463
    Abstract: Compounds of Formula I Each R is independently linear or branched C1 to C8 alkyl, or linear or branched C1 to C8 alkoxy or one R is H and the other R is linear or branched C1 to C8 alkyl, or linear or branched C1 to C8 alkoxy; R1 is selected from the group consisting of COCH3, CO2R3, CONH2, CONH(R4)2, CN, COX(CH2)n-N—(R2)(R4)(R3), and the quaternized salt form of the formula COX(CH2)n-N—(R2)(R4)(R3)+Y−; X is O or NH; n is an integer of 1 to 5; Y is an anion; and R2, R3 and R4 are independently linear or branched C1 to C20. Hair care formulations and other compounds containing compounds of Formula I, and methods for protecting hair and substrates such as polymers, textiles, fabrics, leathers and paints using the compounds herein.
    Type: Grant
    Filed: April 10, 2002
    Date of Patent: March 2, 2004
    Assignee: EM Industries
    Inventor: Ratan K. Chaudhuri
  • Patent number: 6677297
    Abstract: The compounds of the formula in which the dotted line indicates the location of a single or double bond; R1 represents a radical derived from an odoriferous alcohol of the formula R1OH; R2 represents a hydrogen atom, a linear or branched, saturated or unsaturated C1-C30 hydrocarbon radical, or an aliphatic or aromatic cyclic compound having 5 or 6 carbon atoms, this radical R2 possibly comprising heteroatoms of oxygen, sulphur or nitrogen; the symbols R3, R4 and R4′, considered independently, represent a hydrogen atom, a linear or branched, saturated or unsaturated, if necessary substituted, C1 to C20 hydrocarbon radical possibly comprising one or more heteroatoms, or, when considered together with the carbon atoms to which they are bonded, can form aromatic or aliphatic monocyclic, bicyclic or tricyclic compounds, the radicals R3, R4 and R4′ possibly comprising functional groups of the ester and carbamoyl type so as to liberate several molecules of odoriferous alcohol R1OH per s
    Type: Grant
    Filed: March 25, 2002
    Date of Patent: January 13, 2004
    Assignee: Firmenich SA
    Inventor: Eric Frerot
  • Publication number: 20040006235
    Abstract: In a process for the preparation of ring compounds via a combinatorial synthesis, the reaction procedure is based on a Suzuki coupling, subsequent halo-demetallation and finally a further Suzuki coupling. The Suzuki couplings are each carried out with a boronic acid or a boronic acid ester. The reaction procedure uses provides novel ring compounds and uses novel synthesis units used for this purpose. The novel ring compounds are suitable for use as constituents in liquid-crystalline mixtures.
    Type: Application
    Filed: March 17, 2003
    Publication date: January 8, 2004
    Applicant: Merck Patent GmbH
    Inventors: Detlef Pauluth, Peer Kirsch, Peter Baeuerle, Oliver Deeg
  • Patent number: 6664411
    Abstract: The present invention relates to novel antiobesity and hypocholesterolemic compounds, their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them. More particularly, the present invention relates to novel &bgr;-aryl-&agr;-oxysubstituted alkylcarboxylic acids of the general formula (I), their derivatives, their analogs, their tautomeric forms, their stereosomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them.
    Type: Grant
    Filed: March 27, 2001
    Date of Patent: December 16, 2003
    Assignees: Dr. Reddy's Laboratories Limited, Reddy-Cheminor Inc.
    Inventors: Vidya Bhushan Lohray, Braj Bhushan Lohray, Rao Bheema Paraselli
  • Patent number: 6656737
    Abstract: An organic compound useful for detecting the total quantity of isocyanate in an environmental sample is provided. The compound is 9-anthrcenylmethyl-1-piperazinecarboxylate (PAC), an isocyanate derivatizing agent. A process for producing PAC and methods for detecting a particular isocyanate monomer or the total isocyanate in environmental samples using PAC & related isocyanate derivatizing agents are also provided.
    Type: Grant
    Filed: November 10, 2000
    Date of Patent: December 2, 2003
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventor: Robert P. Streicher
  • Patent number: 6652774
    Abstract: The present invention provides a phthalate-free plasticizer for polymer resins. The phthalate-free plasticizer according to the invention includes a mixture of different triesters of glycerin, at least one of which meets the formula: CH2(OOR1)CH(OOR2)CH2(OOR3) wherein at least two of R1, R2, and R3 are different alkyl or aryl groups. Phthalate-free plasticizers according to the invention can be made by esterifying glycerin with a mixture of acids in the presence of a catalyst. Preferably, the mixture of acids includes at least two selected from the group consisting of alkyl acids and aryl acids, with each acid in the mixture containing up to about 11 carbon atoms, and more preferably from about 4 to about 9 carbon atoms each. The plasticizer according to the invention can be used to modify the properties of a wide variety of polymers including vinyl polymers, rubbers, polyurethanes, and acrylics, and has superb thermostability and low volatility.
    Type: Grant
    Filed: December 20, 2001
    Date of Patent: November 25, 2003
    Assignee: Ferro Corporation
    Inventors: Lei Zhou, George Schaefer, William W. Knickmeyer, David Paul
  • Patent number: 6632817
    Abstract: The invention relates to novel fluoromethoximino compounds, to a process for their preparation and to their use as pesticides, and also to novel intermediates and to a plurality of processes for their preparation.
    Type: Grant
    Filed: August 20, 2001
    Date of Patent: October 14, 2003
    Inventors: Ulrich Heinemann, Herbert Gayer, Peter Gerdes, Albrecht Marhold, Uwe Stelzer, Reinhard Lantzsch, Ralf Tiemann, Klaus Stenzel, Astrid Mauler-Machnik, Stefan Dutzmann, Martin Kugler, Hans-Ulrich Buschhaus
  • Patent number: 6627656
    Abstract: This invention encompasses a method for the treatment or prevention of prostaglandin mediated diseases comprising administering to a mammalian patient a compound of formula I: in an amount that is effective to treat or prevent said prostaglandin mediated disease. Novel compounds are also disclosed.
    Type: Grant
    Filed: April 24, 2001
    Date of Patent: September 30, 2003
    Inventors: Michel Gallant, Nicolas Lachance, Marc Labelle, Robert Zamboni, Helene Juteau, Yves Gareau, Patrick Lacombe
  • Publication number: 20030153471
    Abstract: The present invention relates, generally, to a high temperature stable mixed polyol ester lubricant composition partly containing an aromatic carboxylic acid ester and a process of making the same. Typically, the aromatic acid ester is benzoic acid, and the lubricant composition preferably comprises a mixture of linear C5, i-C9, and linear C7-10 aliphatic carboxylic acid. The esters are preferably formed from an aliphatic polyol. These mixed polyol esters are useful in aero-derived gas turbine engines.
    Type: Application
    Filed: November 25, 2002
    Publication date: August 14, 2003
    Inventors: Patrick E. Godici, Jeenok T. Kim, Martin A. Krevalis, Richard H. Schlosberg
  • Patent number: 6600080
    Abstract: In a producing method of alcohols such as cyclohexanedimethanol, a benzyl ester is obtained, for example, by the reaction between a benzyl compound and carboxylic acid in the presence of oxygen and a catalyst including palladium, gold ultra fine particles, and at least one kind of element selected from the group consisting of Group IIA, IIIA, VIA, IIB, VB, and VIII of the periodic table, and alkali metal. The alcohols are produced by hydrogenating a benzene ring of the benzyl ester and then hydrolyzing the resultant esters. Alternatively, the benzyl ester is hydrolyzed to produce benzyl alcohols, and a benzene ring of the benzyl alcohols is hydrogenated to produce the alcohols.
    Type: Grant
    Filed: October 2, 2000
    Date of Patent: July 29, 2003
    Assignee: Nippon Shokubai Co., Ltd.
    Inventors: Yusei Nagamura, Yuuichi Satoh, Jun Tatsumi, Kunihiro Yamamura
  • Patent number: 6600065
    Abstract: Disclosed herein is a novel process for preparing 3-hydroxyesters, comprising: (a) reacting an epoxide derivative with carbon monoxide and alcohol in a solvent at a temperature of 30˜150° C. under a pressure of 50˜3000 psig by using a catalyst system consisting of a catalytic amount of a cobalt compound and optionally an effective amount of a promoter to produce a 3-hydroxyester or a derivative thereof; (b) separating the resulting product and the solvent from the cobalt compound and the promoter in a stripping column at a temperature of −30˜200° C. in an atmosphere of a stabilizing gas; and (c) recycling a part or all of the separated cobalt compound and promoter to the step (a) and repeating the steps (a) through (c).
    Type: Grant
    Filed: October 17, 2002
    Date of Patent: July 29, 2003
    Assignee: Davy Process Technology Ltd.
    Inventors: Byeong No Lee, Eun Joo Jang, Hyung Soo Cho, Byung Soon Chun
  • Patent number: 6590123
    Abstract: The present invention provides for haloacetoamido, benzoic acid derivatives having anti-tumorigenic activity. Examples of the haloacetoamido, benzoic acid derivatives include 3-chloroacetoamido, benzoylurea, 3-bromoacetoamido, benzoylurea, 3-iodoacetoamido, benzoylurea, ethyl-3-chloroacetoamido, benzoate, ethyl-3-bromoacetoamido, benzoate and ethyl-3-iodoacetoamido, benzoate. Intermediates for synthesizing the derivatives, along with methods of making and using the derivatives, are also provided.
    Type: Grant
    Filed: August 29, 2001
    Date of Patent: July 8, 2003
    Assignee: Mount Sinai School of Medicine of New York University
    Inventors: George J Bekesi, Jian-Dong Jiang, Imre Weisz, John Roboz, James F Holland
  • Publication number: 20030125357
    Abstract: Compounds of Formula I 1
    Type: Application
    Filed: May 30, 2002
    Publication date: July 3, 2003
    Inventors: Alan D. Adams, Aileen Bouffard, James F. Dropinski, Clare E. Gutteridge, A. Brian Jones, Weiguo Lui, John George Ondeyka, Ali Shiafee, Sheo Bux Singh
  • Publication number: 20030120104
    Abstract: The present invention provides a phthalate-free plasticizer for polymer resins.
    Type: Application
    Filed: December 9, 2002
    Publication date: June 26, 2003
    Applicant: Ferro Corporation
    Inventors: Lei Zhou, George Schaefer
  • Patent number: 6569826
    Abstract: A new chromotropic compound, compositions containing such a compound and methods of using such compound, such as in a test method for identifying the presence of free radicals, are disclosed.
    Type: Grant
    Filed: April 17, 2002
    Date of Patent: May 27, 2003
    Assignee: The Procter & Gamble Company
    Inventors: Giusepp Chiaradonna, Francesca Cicogna, Giovanni Ingrosso, Emanuela Franchi, Calogero Pinzino, Valerio Del Duca, Stefano Scialla
  • Patent number: 6566560
    Abstract: The invention provides a resorcinol derivative and a method of using the resorcinol derivative to attenuate the growth of a neoplasm.
    Type: Grant
    Filed: August 13, 2001
    Date of Patent: May 20, 2003
    Assignee: Immugen Pharmaceuticals, Inc.
    Inventor: Craig R. Travis
  • Patent number: 6558572
    Abstract: A glass-forming liquid crystal composition comprises a compound having a molecular weight in the range of about 1000 to 5000 grams per mole and having the formula (NEM)x—CYC—(CHI)y wherein CYC is a substituted cycloaliphatic core moiety containing about 24 to about 60 carbon atoms or a substituted aromatic core moiety containing about 6 to about 36 carbon atoms, NEM is a nematogenic pendant moiety, CHI is a chiral pendant moiety, x is 3 to 9, and y is 0 to 4. An optical device is formed from the liquid crystal composition.
    Type: Grant
    Filed: December 19, 2000
    Date of Patent: May 6, 2003
    Assignee: University of Rochester
    Inventors: Shaw H. Chen, Fred Y. Fan
  • Patent number: 6548547
    Abstract: The present invention relates to compounds of the formula I in which A1, A2, R2 and R3 have the meanings indicated in the claims, which are valuable pharmaceutical active compounds for the therapy and prophylaxis of diseases, for example of cardiovascular disorders such as high blood pressure, angina pectoris, cardiac insufficiency, thromboses or atherosclerosis. The compounds of the formula I have the ability to modulate the endogenous production of cyclic guanosine monophosphate (cGMP) and are generally suitable for the therapy and prophylaxis of disease states which are associated with a disturbed cGMP balance. The invention relates to the use of compounds of the formula I for the therapy and prophylaxis of the designated disease states and for the production of pharmaceuticals therefor, novel compounds of the formula I, pharmaceutical preparations comprising them and processes for their preparation.
    Type: Grant
    Filed: March 8, 2001
    Date of Patent: April 15, 2003
    Assignee: Aventis Pharma Deutschland GmbH
    Inventors: Ursula Schindler, Karl Schoenafinger, Hartmut Strobel
  • Publication number: 20030065206
    Abstract: This invention provides improved methods for the derivatization and solubilization of fullerenes, which are particularly useful for those fullerenes that are normally insoluble and which are specifically applied, among others, to endohedral fullerenes, including endohedral metallofullerenes; empty fullerenes, including small-bandgap fullerenes and other insoluble fullerenes and to very high molecular weight fullerenic materials generated in fullerenic soot, including giant fullerenes, fullerenic polymers, carbon nanotubes and metal-carbon nanoencapsulates. More specifically the invention relates to improved methods for cyclopropanation of fullerenes. Specific reaction conditions are provided which allow for cyclopropanation reactions to be successfully performed for the first time on insoluble classes of fullerenes.
    Type: Application
    Filed: October 1, 2002
    Publication date: April 3, 2003
    Inventors: Robert D. Bolskar, J. Michael Alford
  • Patent number: 6538150
    Abstract: The present invention relates to a compound of the formula (I) The compound according to the invention is suitable for the preparation of herbicidal active substances such as sulfonylureas.
    Type: Grant
    Filed: July 20, 2001
    Date of Patent: March 25, 2003
    Assignee: Aventis CropScience GmbH
    Inventors: Klaus Lorenz, Hans-Joachim Ressel, Lothar Willms
  • Publication number: 20030055280
    Abstract: Novel platform molecules and polymerizable mesogens made therefrom; novel synthetic pathways for making such platform molecules and polymerizable mesogens.
    Type: Application
    Filed: January 23, 2002
    Publication date: March 20, 2003
    Inventors: Stephen T. Wellinghoff, Douglas P. Hanson
  • Publication number: 20030055286
    Abstract: 1 This invention relates to novel compounds of Formula (I) to (VII), and compositions thereof, useful in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8).
    Type: Application
    Filed: September 5, 2002
    Publication date: March 20, 2003
    Inventors: Katherine Louisa Widdowson, Qi Jin
  • Publication number: 20030049714
    Abstract: The subject invention provides compounds useful as fluorogenic substrates for the hydrolytic enzymes. Upon hydrolysis of the hydrolyzable group, a halo-pyrene substituted molecule is developed which is highly fluorescent, water soluble and exhibits several desirable characteristics, including a large Stokes' shift.
    Type: Application
    Filed: August 27, 2002
    Publication date: March 13, 2003
    Inventors: Michael J. Conrad, Liyan He
  • Patent number: 6531624
    Abstract: A process for producing a benzoylacrylic acid derivative (formula 1) in high yield through a small number of steps and a simple purification step. The process comprises reacting 2,4,5-trifluoro-3-methyl-6-nitrobenzoyl chloride with a compound (formula 2) to yield an aminoacrylic acid derivative (formula 1) and then reacting the aminoacrylic acid derivative (formula 1) with an amine derivative represented by R2—NH2, wherein R2 is a cycloalkyl group or the like.
    Type: Grant
    Filed: May 18, 2001
    Date of Patent: March 11, 2003
    Assignees: Asahi Glass Company Ltd., Katayama Seiyakusyo Co., Ltd.
    Inventors: Naoto Morita, Takashi Inagaki
  • Patent number: 6528677
    Abstract: This invention relates to new RAR selective retinoid agonists of formula I: wherein the symbols are as defined in the specification to their pharmaceutically acceptable salts, individual isomers or to a racemic or non-racemic mixture; to pharmaceutical compositions containing them, and to methods for their use as therapeutic agents.
    Type: Grant
    Filed: July 26, 2000
    Date of Patent: March 4, 2003
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Paula Nanette Belloni, Michael Klaus, Jean-Marc Lapierre
  • Patent number: 6528676
    Abstract: The application discloses methods of treating mammalian diseases characterized by abnormal cell mitosis by administering estradiol derivatives including those comprising colchicine or combretastatin A-4 structural motifs of the general formulae found below in a dosage sufficient to inhibit cell mitosis. The application discloses novel compounds used in the methods.
    Type: Grant
    Filed: February 2, 1999
    Date of Patent: March 4, 2003
    Assignee: The Children's Medical Center Corporation
    Inventors: Robert John D'Amato, Moses Judah Folkman
  • Patent number: 6525210
    Abstract: Chiral ligands and transition metal complexes based on such chiral ligands useful in asymmetric catalysis are disclosed. The chiral ligands include phospholanes, P,N ligands, N,N ligands, biphenols, and chelating phosphines. The ferrocene-based irridium (R,R)-f-binaphane complex reduces imines to the corresponding amines with 95-99.6% enantioselectivity and reduces &bgr;-substituted-&agr;-arylenamides with 95% enantioselectivity. The transition metal complexes of the chiral ligands are useful in asymmetric reactions such as asymmetric hydrogenation of imines, asymmetric hydride transfer reactions, hydrosilylation, hydroboration, hydrovinylation, hydroformylation, allylic alkylation, cyclopropanation, Diels-Alder reaction, Heck reaction, isomerization, Aldol reaction, Michael addition and epoxidation reactions.
    Type: Grant
    Filed: August 22, 2000
    Date of Patent: February 25, 2003
    Assignee: The Penn State Research Foundation
    Inventors: Xumu Zhang, Dengming Xiao
  • Patent number: 6515163
    Abstract: The invention concerns hydrogenated phenanthrenes of formula I wherein the parameters have the meanings given in the text and their use in liquid crystal compositions.
    Type: Grant
    Filed: June 8, 2001
    Date of Patent: February 4, 2003
    Assignee: Merck Patent Gesellschaft
    Inventors: Rainer Wingen, Barbara Hornung, Wolfgang Schmidt
  • Patent number: 6514632
    Abstract: A compound of the formula: and compounds of the formulas: wherein R1 is independently in each occurrence C1-20 hydrocarbyl or C1-20 hydrocarbyl containing one or more S, N, O, P or Si atoms, C4-16 hydrocarbyl carbonyloxy, C4-16 aryl(trialkylsiloxy) or both R1 may form with the 9-carbon on the fluorene ring a C5-20 ring structure or a C4-20 ring structure containing one or more heteroatoms of S, N or O; R2 is independently in each occurrence C1-20 hydrocarbyl, C120 hydrocarbyloxy, C1-20 thioether, C1-20 hydrocarbylcarbonyloxy or cyano; R3 is independently in each occurrence C1-20 hydrocarbyl or C1-20 hydrocarbyl substituted with di(C1-20 alkyl)amino, C1-20 hydrocarbyloxy or C1-20 hydrocarbyl or tri(C1-10 alkyl)siloxy; a is independently in each occurrence 0 or 1; X is independently in each occurrence a halogen moiety; and Z is independently in each occurrence —B(OH)2, —B(OR4)2 or  wherein R4 is independently in each occurrence a C1-10
    Type: Grant
    Filed: September 13, 2000
    Date of Patent: February 4, 2003
    Assignee: Dow Global Technologies Inc.
    Inventors: Edmund P. Woo, William R. Shiang, Michael Inbasekaran, Gordon R. Roof, Mark T. Bernius, Weishi Wu
  • Patent number: 6515167
    Abstract: A low temperature process for preparing a methyl ester having formula (III) said process comprising reacting a carboxylic acid or salt thereof having formula (I) with dimethyl carbonate having formula (II) in the presence of a catalyst selected from the group consisting of 1,8 diazabicyclo[5.4.0]undec-7-ene; 1,4-diazabicyclo[2.2.2]octane; and combinations thereof, wherein said process is conducted at a temperature of about 10° C. to less than 120° C.; R1 is selected from the group consisting of an alkyl, aryl, alkoxy, alkenyl, cycloalkyl, benzocycloalkyl, cycloalkylalkyl, aralkyl, heterocyclic, heteroaralkyl, alkoxyalkyl, carboxyalkyl, alkylcarbonyl, alkoxycarbonyl, alkoxycarbonylalkyl and haloalkyl; and M is selected from the group consisting of hydrogen, a monovalent metal and a monovalent fractional part of a polyvalent metal.
    Type: Grant
    Filed: April 26, 2002
    Date of Patent: February 4, 2003
    Assignee: Novartis AG
    Inventors: Wen-Chung Shieh, Steven J. Dell
  • Patent number: 6512083
    Abstract: A compound of the formula: and compounds of the formulas: wherein R1 is independently in each occurrence C1-20 hydrocarbyl or C1-20 hydrocarbyl containing one or more S, N, O, P or Si atoms, C4-16 hydrocarbyl carbonyloxy, C4-16 aryl(trialkylsiloxy) or both R1 may form with the 9-carbon on the fluorene ring a C5-20 ring structure or a C4-20 ring structure containing one or more heteroatoms of S, N or O; R2 is independently in each occurrence C1-20 hydrocarbyl, C1-20 hydrocarbyloxy, C1-20 thioether, C1-20 hydrocarbylcarbonyloxy or cyano; R3 is independently in each occurrence C1-20 hydrocarbyl or C1-20 hydrocarbyl substituted with di(C1-20 alkyl)amino, C1-20 hydrocarbyloxy or C1-20 hydrocarbyl or tri(C1-10 alkyl)siloxy; a is independently in each occurrence 0 or 1; X is independently in each occurrence a halogen moiety; and Z is independently in each occurrence —B(OH)2, —B(OR4)2 or  wherein R4 is independently in each occurrence a C1-
    Type: Grant
    Filed: September 13, 2000
    Date of Patent: January 28, 2003
    Assignee: Dow Global Technologies Inc.
    Inventors: Edmund P. Woo, William R. Shiang, Michael Inbasekaran, Gordon R. Roof, Mark T. Bernius, Weishi Wu
  • Patent number: 6506928
    Abstract: The invention relates to dendrimeric fullerene derivatives in which the fullerene is linked to at least one dendron, wherein the or each dendron has at least one protic group which imparts water solubility.
    Type: Grant
    Filed: August 31, 2000
    Date of Patent: January 14, 2003
    Assignee: Siemens Axiva GmbH & Co. KG
    Inventor: Andreas Hirsch
  • Patent number: 6503949
    Abstract: Disclosed is a novel class of compounds of formula (I) wherein V, A, Y, Z, R1, E, X and D are as defined in the specification. These compounds act to antagonize the action of the glucagon hormone on the glucagon receptor. Owing to their antagonizing effect of the glucagon receptor, the compounds are suitable for treating or preventing glucagon-mediated conditions and diseases such as hyperglycemia, Type 1 diabetes, Type 2 diabetes and obesity.
    Type: Grant
    Filed: May 16, 2000
    Date of Patent: January 7, 2003
    Assignee: Noro Nordisk A/S
    Inventors: Jesper Lau, Peter Madsen, Christian Sams, Carsten Behrens, Josef Vagner, Inge Thøger Christensen, Behrend Frederik Lundt, Ulla Grove Sidelmann, Henning Thøgersen, Anthony L. Ling, Michael Bruno Plewe, Larry Kenneth Truesdale, Shenghua Shi
  • Publication number: 20030003397
    Abstract: A compound of Formula 10, an organic anti-reflective polymer having the structure of Formula 1 synthesized from the compound of Formula I and a preparation method thereof. An anti-reflective coating composition including the above organic anti-reflective polymer, as well as a preparation method of an anti-reflective coating. The anti-reflective coating comprising the disclosed polymer eliminates standing waves caused by the optical properties of lower layers on the wafer and by the changes in the thickness of the photoresist, prevents back reflection and also solves the problem of CD alteration cause by the diffracted and reflected light from such lower layers. Such advantages enable the formation of stable ultrafine patterns suitable for 64M, 256M, 1G, 4G, and 16G DRAM semiconductor devices and an increase of the production yields. Further, it is also possible to control the k value.
    Type: Application
    Filed: March 13, 2002
    Publication date: January 2, 2003
    Inventors: Sung-eun Hong, Min-ho Jung, Jae-chang Jung, Geun-su Lee, Ki-ho Baik
  • Publication number: 20020193482
    Abstract: Bis(cis-3,3,5-trimethylcyclohexyl) phthalate includes stereoisomers represented by following Formulae (1), (2) and (3) and satisfies the following conditions: 1
    Type: Application
    Filed: March 1, 2002
    Publication date: December 19, 2002
    Inventors: Ikuo Takahashi, Tomohiro Hashizume, Kazuhiro Nakanishi
  • Publication number: 20020193421
    Abstract: There are provided compounds represented by the formula I 1
    Type: Application
    Filed: February 13, 2002
    Publication date: December 19, 2002
    Inventors: Anna Ericsson, Anne Marinier, Fred C. Zusi
  • Patent number: 6495710
    Abstract: The synthesis of dimethyl-1,5-naphthalenedicarboxylate and polymers and articles formed therefrom is disclosed, as well as applications for dimethyl-1,5-naphthalenedicarboxylate, its corresponding acid 1,5-NDA, and various synthesis intermediates.
    Type: Grant
    Filed: January 12, 2001
    Date of Patent: December 17, 2002
    Assignee: BP Corporation North America Inc.
    Inventors: John A. Macek, Bruce I. Rosen, Juergen K. Holzhauer, John S. Bramlet, Larry D. Lillwitz, David J. Schneider, Lawrence L. Lang, Edward E. Paschke, John M. Weis, Yenamandra Viswanath, Stefanos L. Sakellarides
  • Patent number: 6486342
    Abstract: A family of substituted chiral allosteric effectors of hemoglobin is useful for delivering more oxygen to hypoxic and ischemic tissues by reducing the oxygen affinity of hemoglobin in whole blood.
    Type: Grant
    Filed: August 23, 2000
    Date of Patent: November 26, 2002
    Assignee: Virginia Commonwealth University
    Inventors: Donald J. Abraham, Gajanan S. Joshi, Stephen J. Hoffman, Melissa Grella, Richmond Danso-Danquah, Amal Yousseff, Martin Safo, Sanjeev Kulkarni
  • Patent number: 6486178
    Abstract: The present invention provides medicines for treating cardiac insufficiency which contain as an active ingredient indane derivatives of formula (I) wherein R1 represents hydrogen atom, nitro group, cyano group, C1-6 alkylcarbonylamino, R2 and R3 each independently represent C1-6 alkyl group, R4 represents hydroxyl group or C1-6 alkylcarbonyloxy group or represents a bond or oxygen atom together with R5, R5 represents hydrogen atom or represents a bond or oxygen atom together with R4, R6 represents hydrogen atom, hydroxyl group or NR7R8, n means 0 or an integer of 1 to 4, X represents C═O, CH2, SO2 or NR16, Y represents NR17 when X is C═O, CH2 or SO2 and represents C═O when X is NR16, Z is absent when Y represents NR17 or represents NR18 when Y is C═O, W represents aromatic groups or lactam rings, or pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: November 28, 2000
    Date of Patent: November 26, 2002
    Assignee: Nissan Chemical Industries, Ltd.
    Inventors: Keizo Tanikawa, Kazuhiko Ohrai, Masayuki Sato, Kazufumi Yanagihara, Yukihiro Shigeta, Toru Yamashita
  • Patent number: 6476076
    Abstract: The present invention is related to new vanilloid analogues containing resiniferatoxin pharmacophores, pharmaceutical compositions comprising such analogues, and their uses as vanilloid receptor agonists and potent analgesics. The present invention provides a pharmaceutical composition for treating acute, chronic, inflammatory or neuropathic pains or for treating bladder hypersensitivity.
    Type: Grant
    Filed: August 20, 2001
    Date of Patent: November 5, 2002
    Assignees: Pacific Corporation, Digital Biotech Co., Ltd.
    Inventors: Jeewoo Lee, Uhtaek Oh, Young-Ho Park, Young-Ger Suh, Hyeung-Geun Park, Hee-Doo Kim
  • Patent number: 6465664
    Abstract: One aspect of the present invention relates to methods for the transition-metal-catalyzed asymmetric 1,4-addition of a nucleophile, e.g., hydride, to cyclic and acyclic enoates and enones. In certain embodiments of the methods of the present invention, the transition metal catalyst consists essentially of copper and an asymmetric bidentate bisphosphine ligand.
    Type: Grant
    Filed: September 13, 2000
    Date of Patent: October 15, 2002
    Assignee: Massachusetts Institute of Technology
    Inventors: Stephen L Buchwald, Daniel H. Appella, Yasunori Moritani, Ryo Shintani, Valdas Jurkauskas
  • Patent number: 6458948
    Abstract: A method of preparing carboxylic acid derivatives comprising mixing a quaternary ammonium salt having a particular triazine ring in the molecules thereof, a carboxylic acid compound and a compound having a nucleophilic functional group, to condense the carboxylic acid with the compound having the nucleophilic functional group. The invention further provides a condensing agent comprising the quaternary ammonium salt. The condensation is conducted under mild conditions to form carboxylic acid derivatives and, particularly, amide compounds or ester compounds maintaining high yields.
    Type: Grant
    Filed: December 11, 2000
    Date of Patent: October 1, 2002
    Assignee: Tokuyama Corporation
    Inventors: Fumiaki Iwasaki, Shohei Tani, Munetaka Kunishima, Keiji Terao, Michiko Miharu, Naoki Hirano, Masako Saijyo
  • Publication number: 20020133039
    Abstract: The present invention provides a method for enantioselectively reducing a prochiral carbon centered radical having one or more electron donator groups attached directly to the central prochiral carbon atom of the radical, and/or attached to a carbon atom within 1 to 4 atoms of the central prochiral carbon atom, comprising treating said radical with a chiral non-racemic organotin hydride in the presence of a Lewis acid.
    Type: Application
    Filed: July 27, 2001
    Publication date: September 19, 2002
    Inventors: Dainis Dakternieks, Carl H. Schiesser, Tamara Perchyonok
  • Patent number: 6448412
    Abstract: The invention is directed to multiply-substituted fullerene derivatives of novel configurations, and methods for their preparation and use. The methods involve the combinatorial synthesis of a library of fullerene derivatives and comprises the steps of forming a mixture of fullerene derivatives by reacting the Cn fullerene with two or more reactive precursor compounds, and removing the unreacted compounds to yield the fullerene derivatives having the desired activity. Methods for the identification and screening of a combinatorial library of fullerenes by 3He-nuclear magnetic resonance and electrospray mass spectrometry to define members with the optimal desired activity are also provided.
    Type: Grant
    Filed: October 30, 2000
    Date of Patent: September 10, 2002
    Assignee: Sphere Biosystems, Inc.
    Inventors: Randall B. Murphy, Stephen R. Wilson, Quing Lu
  • Publication number: 20020115575
    Abstract: Lubricating oil compositions providing superior soot dispersing characteristics, which contain a combination of a high molecular weight dispersant and a soot dispersant comprising a linked aromatic oligomer.
    Type: Application
    Filed: December 22, 2000
    Publication date: August 22, 2002
    Inventors: Antonio Gutierrez, Ricardo A. Bloch, Nancy Z. Diggs, Fredrick W. Girschick, David J. Martella, Mark G. Stevens, Jacob Emert
  • Patent number: 6436991
    Abstract: Ferulate compounds derived from extracts from the plant Commiphora wightii are used in compositions and methods for prevention and treatment of abnormal cell growth and proliferation in inflammation, neoplasia and cardiovascular disease.
    Type: Grant
    Filed: May 21, 2001
    Date of Patent: August 20, 2002
    Assignees: Sabinsa Corporation, Sami Chemicals & Extracts (P) Ltd.
    Inventors: Muhammed Majeed, Vladimir Badmaev, Rajinder Kumar Bammi, Subbalakshmi Prakash, Sankaran Natarajan
  • Patent number: 6414178
    Abstract: This invention relates to a process and apparatus for the continuous preparation of mono and bis-chloroformate products of halogenated dihydroxy compounds by an interfacial process. The mono and bis-chloroformate products may optionally be converted to capped oligomers.
    Type: Grant
    Filed: July 25, 2000
    Date of Patent: July 2, 2002
    Assignee: General Electric Company
    Inventors: James Manio Silva, David Michel Dardaris, Thomas Joseph Fyvie, Pierre-Andre Bui, Daniel Joseph Brunelle