Abstract: The present invention relates to a supplementary device a supplementary device for a manually operable injection device. The supplementary device has a body defining a passage through which an injection device is slidable, and a securing unit to secure the body to the injection device in the specific position when the injection device is received through the passage.

Abstract: A liquid embolic material may include a mixture of a first solution comprising between about 1.2% and about 2.5% weight per volume (w/v) carboxymethyl chitosan (CCN) in a first solvent and a second solution comprising between about 1.2% and about 2.5% w/v oxidized carboxymethyl cellulose (OCMC) in a second solvent. The liquid embolic material may be used to embolize a targeted embolization location by mixing the first solution and the second solution to form a liquid embolic material (or hydrogel precursor material), introducing the hydrogel precursor material to a targeted embolization location within a body of a patient, and allowing the CCN and the OCMC to react to form the hydrogel material and embolize the targeted embolization location.

Abstract: The present invention relates to a supplementary device for a manually operable injection device. The device has a body and a mating unit configured to releasably mount the body to the injection device in a specific position relative to an outside surface of the injection device.

Abstract: A lacrimal drainage manometer includes a syringe having a syringe body and a piston. The syringe body defines a fluid cavity in fluid communication with a cannula configured for insertion into at least a portion of a lacrimal drainage system. The piston dispenses a fluid from the fluid cavity through the cannula. A pressure sensor is operably coupled to the syringe for measuring fluid pressure in the fluid cavity. A position sensor operably coupled to the syringe measures the position of the piston relative to the syringe body. A user feedback unit in electrical communication with the pressure sensor and the position sensor provides user feedback based on data from at least one of the pressure sensor and the position sensor indicative of a condition of the lacrimal drainage system.

Abstract: A medication delivery pen assembly having a pen body and a needle assembly with a hub connected to the pen body, a needle cannula extending through the hub with a distal end sharpened for insertion into a patient, and a shield having a tubular portion telescopingly disposed about at least a portion of the hub. The tubular portion includes an internal surface, at least one projection extending inwardly from the internal surface, and the hub having at least one externally extending projection. The shield is axially displaceable relatively along the hub distally from a first position, where the distal end of the needle cannula is exposed, to a second position, where the distal end of the needle cannula is enclosed by the shield.

Abstract: An autoinjection device includes a main body 12 in the front end of which is slideably mounted a drawer or front body portion 14. The drawer can be opened to remove or insert a syringe. Closing the drawer while pressing a multifunction button 22 primes the drive mechanism 54, 58 by latching it against trigger latch 66. Pressing the button 22 again while urging the front end causes the drawer to release the trigger latch 66. After the injection the drawer shrouds the used needle and can be released only by pressing the button 22.

Abstract: A medicament delivery device includes a housing for a medicament container assembly; a drive member interactively connected to the assembly for expelling a dose of medicament; a dose actuation assembly operably connected to the drive member; and an actuation member interactively connected to the housing and the dose actuation assembly by a gear assembly. The actuation member is movable generally perpendicularly to a longitudinal axis of the device from an initial position, in which the actuation member is positioned within the housing, to a dose-set position, in which a portion of the actuation member protrudes a distance proportional to the set dose from the longitudinal surface of the housing when the dose actuation assembly. The actuation member is manually operated in a direction generally perpendicular to the longitudinal axis of the device from the dose-set position to the initial position for driving the dose actuation assembly and drive member.

Abstract: Medicament delivery device comprising an elongated housing (10) comprising a grip member (64) connected to the elongated housing and movable between a rest position in which the device has a predetermined grip size and an operation position in which the pre-determined grip size of the device is increased for providing an improved grip of the device during use.

Abstract: Disposable items made from bioplastic resins include a biodegradable resin selected from the group consisting of polylactic acid (PLA), cellulose based PH, polycaprolate (PCL), polybutyleneadipatetetephathalate (PBT), polyhydroxyalkanoate (PHA), green polyethylene (GPE), and green polyethylene terephthalate (GPET); a plasticizer intermixed with the resin to provide a generally homogenous bioplastic; and a device formed from the bioplastic, where the device is at least one of a multidose syringe, a sharps container, or a suction canister. A method of disposing of an item includes providing an item made from a biodegradable resin and a plasticizer that are intermixed to provide a generally homogenous bioplastic; sterilizing the item; shredding the item; and composting the item into a compost end product, thereby disposing of the item.

Abstract: The present disclosure presents systems, devices and methods for injection of drugs, substances and/or chemicals to a patient and for improving their effectiveness once they are injected are disclosed. Additional treatment can be applied to a tissue region on the patient into which a drug (e.g., insulin) is injected, to expose the tissue region to various forms of energy or a substance to improve the drug's pharmacokinetic and/or pharmacodynamic profile.

Abstract: A Luer securement device comprising a Luer adapter having a septum and a catheter hood, the Luer adapter further having a wedge seal for receiving a base portion of a catheter. The Luer securement device further includes an inserter body in which is slidably housed a catheter threader having a probe which is configured to advance a base portion of a catheter through the septum thereby seating the base portion of the catheter into the wedge seal of the Luer adapter as a tip portion of the catheter is inserted into a patient. The catheter threader further includes a needle adapter having a needle which is threaded through the probe and the catheter to assist in inserting the catheter into the patient. Following insertion of the catheter, the catheter threader is retracted within the inserter body thereby withdrawing the needle from the catheter and shielding a sharpened tip of the needle within at least one of the inserter body and the catheter threader.

Abstract: An autoinjector includes a housing (10) to receive a syringe (14), and a drive mechanism including first and second springs (30, 32) operating in tandem via an intermediate member (34), on a plunger (42). The plunger is retained in a locked position by a trigger. Release of the trigger causes the first spring to advance the syringe to an arrest point whereafter the second spring extends within the syringe to expel a dose.

Abstract: Disclosed are pharmaceutical compositions containing clodronic acid and hyaluronic acid or their salts as active constituents, mixed with suitable vehicles.

Abstract: The invention relates to an auto-injector (1) with a delay mechanism (36) for slowing down motion of a retraction sleeve (10) in axial direction of the auto-injector (1), the delay mechanism (36) comprising a circumferential outer wall (37) with a back collar (38) attached to a housing (2) of the auto-injector (1) and a circumferential inner wall (39) with a front collar (40) attached to the retraction sleeve (10) wherein a cavity is defined between the outer wall (37) and inner wall (39), the cavity sealed by the back collar (38) against the inner wall (39) and by the front collar (40) against the outer wall (37), the cavity filled with a viscous fluid, wherein at least one orifice is arranged in the delay mechanism (36) for allowing the viscous fluid to be pushed out as the volume of the cavity decreases due to axial motion of the component with respect to the housing.

Abstract: The present invention relates to method of manufacturing a fluid guiding assembly for a drug delivery device and to a respective fluid guiding assembly. Said method comprising the steps of: providing a first member having at least one recess in a first surface portion, at least partially filling the recess with a joining component at least partially protruding from the first surface portion of the first member, arranging a second member having a second surface portion adjacent to the first member such that first and second surface portions thereof face towards each other to form an interface area between the first and the second members, wherein the joining component comprises a material different to the material of the first and/or second member wherein at least one channel structure extending along the interface area is formed by at least one deepening of the first member and/or of the second member, selectively providing thermal energy to the joining component to bond together first and second members.

Abstract: The present invention relates to sustained release formulations comprising as active ingredient octreotide or a pharmaceutically-acceptable salt thereof and two different linear polylactide-co-glycolide polymers (PLGAs).

Abstract: The present invention relates to a container comprising: a body; a pusher movable with respect to the body between an initial position and an end-of-use position; a locker located on the pusher and forming an abutment so as to be able to abut against the body between the initial position and the end-of-use position, wherein, the abutment abuts against the body to limit distal movement of the pusher relative to the body to a pusher locking position located between the initial position and the end-of-use position; a locking arrangement capable of, temporarily, locking the locker on the pusher so as to define a locker locking position of the locker on the pusher, the locker locking position establishing the position of the abutment relative to the pusher so as to set the pusher locking position; and, an unlocking arrangement designed so that, with triggering, the locking arrangement is released so as to allow the locker to be displaced relative to the pusher and for the pusher to be moved past the pusher locking

Abstract: An automatic mixing device, an actuating device having integrated plunger and configured to be removably mounted to the automatic mixing device, and a retractable syringe having the automatic mixing device are provided. The actuating device has an initially compressed spring and a trigger member that is rotatable to initiate spring decompression to drive depression of a mixing plunger seal of the automatic mixing device. Another seal located in an outer chamber of the mixing device is capable of axial movement upon depression of the mixing plunger, from a first position in sealing engagement with one or more apertures in an inner barrel to a second position intermediate the apertures and vents in an outer barrel. This allows depression of the mixing plunger to force a first substance from the outer chamber through the apertures to mix with a second substance in an inner chamber of the inner barrel. The mixed substance in the inner barrel is then delivered by the syringe with subsequent needle retraction.

Abstract: A syringe containing a compressible porous matrix, which compressible porous matrix has in it a pharmaceutical in a soluble glass, Methods of producing and using the syringe, and compressible porous matrix inserts for insertion into a syringe barrel are also provided.

Abstract: A syringe assembly includes a syringe barrel defining a chamber, a stopper disposed within the chamber, and a plunger assembly. The plunger assembly includes an elongated plunger rod, a housing, and a handle portion connecting the plunger rod and housing. The plunger assembly transitions from a first position disposed about the syringe barrel, to a second position with the plunger rod engaged with the stopper. Transition of the plunger assembly includes rotational engagement of the plunger rod and stopper.

Abstract: The present invention relates to a time delay indicator (1) for an injection device for administering a drug into the body of a subject user wherein the time delay indicator is configured for indicating after administration that a dose of the drug actually has been administered and for maintaining this indication until lapse of a pre-determined time interval. The time delay indicator is based on a magnetic liquid (6) being physically moved by a magnet (10).

Abstract: Described is a syringe carrier comprising a body adapted to receive a barrel of a syringe. The body includes a longitudinal slot and a distal end having resilient distal clamps with shoulder sections. The shoulder sections are adapted to engage a circumferential gap between the barrel of the syringe and a needle shield covering a needle of the syringe.

Abstract: The present invention relates to a medicament delivery device comprising a housing (12); a medicament container (14) arranged within said housing; medicament delivery drive means (22, 24); manually operable release means (38); and a movement speed control mechanism (44, 46, 48) comprising at least one fixed, flexible and elongated compartment (48) containing a liquid, and at least one flexible speed control member (44, 46) connected to the medicament delivery drive means; wherein said at least speed control member is arranged to be pressing on said at least one compartment for forcing said liquid past said member and thereby creating a movement speed control of said medicament delivery drive means when moved.

Abstract: A method for delivering medicament such as for ameliorating pain in a patient includes introducing an injector through a nasal passage of the patient into a region substantially medial and/or posterior and/or inferior to a sphenopalatine ganglion (SPG) of the patient; and delivering a medicament from the injector superiorly and/or laterally and/or anteriorly towards the SPG. A device for delivering a medicament to a patient in need thereof includes (a) an injector containing a first end configured to remain outside a nasal passage of the patient and a second end configured for entry into the nasal passage of the patient; and (b) an introducer configured for engagement with a nostril of the patient and containing a passageway configured for slidably receiving the injector. The injector is moveable between a storage position preceding the engagement and an engaging position pursuant to the engagement.

Abstract: A method of molding a solid article such as a syringe with zero draft or very low draft is disclosed. The method includes heating a low draft mold to expand it, then injection molding the part, followed by cooling at least part of the low draft mold element to thermally contract at least a portion of the low draft element away from the solid low draft formed surface sufficiently to release the low draft element from the low draft formed surface. Syringes and other articles formed by this method are also disclosed having and interior draft angle of 0 to 0.5 degrees, optionally at least substantially zero degrees. The syringe plunger can be selectively coated with lubricity coatings and other functional coatings to improve performance of the syringe.

Abstract: A device for making an incision in the tympanic membrane, withdrawing fluid from the tympanic cavity and administering a medicament to the space behind the tympanic membrane is provided. The device has a barrel-shaped casing (1) having a rotatable end turret (38). A first trigger (2) allows a shaft (18) to pierce the tympanic membrane and a tubular vacuum cartridge (32). The cartridge allows aspiration of fluid. A second trigger (4) causes medicament (34) to be released into the space behind the tympanic membrane.

Abstract: A fluid guiding assembly for a drug delivery device is presented having a first member, a cover part adjacently disposed to the first member and being in non-bonded surface contact with a surface portion of the first member thereby forming an interface area, at least one channel structure extending along the interface area of first member and cover part and being formed by at least one recess in either the first member and/or in the cover part, and a second member being in contact with the cover part and being bonded to the first member by way of injection moulding to fix the cover part relative to the first member.

Abstract: The present disclosure relates to an operation aid for a medication delivery device, which is configured to alleviate the operation of an actuator of the medication delivery device. Furthermore, a system comprising a medication delivery device and an operation aid is disclosed.

Abstract: Disposable items made from bioplastic resins include a biodegradable resin; and a plasticizer; wherein the resin and plasticizer are intermixed to provide a generally homogenous bioplastic that is formed to provide the device. A disposable device includes a multidose syringe, a specimen tube, a scalpel, a lancet, a sharps container, or a suction canister. A method of disposing of an item includes providing an item made from a biodegradable resin and a plasticizer that are intermixed to provide a generally homogenous bioplastic; sterilizing the item utilizing radiation or ethylene oxide gas; shredding the item; and composting the item into a compost end product, thereby disposing of the item.

Abstract: Injection devices with ergonomic enhancements are disclosed. Generally, the injection devices include large oversized grips, including flanges at the base end of the device for enhanced stability. Push-type and squeeze-type devices are described, as well as manual injectors and auto-injectors. Such injection devices are useful for delivering a fluid (e.g. medication) to a patient.

Abstract: The present invention relates to a medicament delivery device (10) comprising a front housing (12) and a rear housing (14) connected to each other; a medicament container (18) disposed within the front housing (12), wherein the container (18) has a front opening with or for a delivery member for delivering the medicament therethrough and at least one movable stopper (25); and a compression spring (26) having a predetermined compressed length and a predetermined outer diameter, wherein the compressed length is the length of the spring when it is in a pre-tensioned state; wherein the device further comprises a first guide means comprising a front part (28) having a predetermined first length (61), a middle part (42) having a predetermined second length (62), and a rear part (34) having a predetermined third length (63), wherein said predetermined third length corresponds to the predetermined compressed length of the compression spring, wherein the front part (28) is arranged to be in contact with the movable st

Abstract: A syringe assembly including: (1) a syringe barrel defining a chamber; (2) a plunger mounted in the chamber and moveable with respect to the barrel; and (3) a cap assembly containing a cap and an absorbent material is removably attached to the plunger.

Abstract: A retractable syringe, comprising a needle having a tip and a base, a needle collar coupled to the needle, the needle collar including at least one groove disposed in a bottom portion of the needle collar and extending from the portion of the needle collar nearest to the base of the needle toward the tip of the needle, a fitting coupled to the needle collar and including a sealing element disposed between a first portion of the fitting and the needle collar, a barrel unit, the barrel unit designed for coupling to the fitting, a plunger unit having a piston on a first end of the plunger unit, the plunger unit and piston being positioned in the barrel unit, an extractor element coupled to the first end of the plunger and having a proximal end adjacent to the plunger and a distal end, the extractor element designed for coupling to the needle collar and encompassing at least a portion of the at least one groove.

Abstract: A drive mechanism for a medication delivery device containing a resilient member and having a rotation member configured to be rotated in a first direction during setting of a dose of a medication and to be rotated in a second direction during delivery of the dose, where rotation member is coupled to a drive member that is coupled to a piston rod such that on dose delivery the piston rod is displaced in a distal direction to dispense a medicament and where the resilient member prevents movement of the drive member and the piston rod during dose setting.

Abstract: A syringe and needle assembly includes a needle that extends through the barrel of the syringe and is attached to a proximal portion of the syringe. The distal end of the needle extends through a sleeve attached to the distal end of the syringe. The proximal end of the needle includes a spring which biases the needle proximally, so that the distal tip of the needle is normally retracted within the sleeve. The assembly can be used for injections in portions of a patient's body including delicate tissues that could be damaged if contacted by the needle tip.

Abstract: A cleaning device includes a cap having an opening and that defines an inner cavity, and a channel that extends from a bottom of the inner cavity to a bottom of the cap. A plunger includes a domed top surface, a shoulder, and a rod member. The plunger moves toward the bottom of the cap as the domed top surface is contacted by a male protrusion of a male medical implement, to push the rod member and piercing end further into the channel. The crush ribs contact an inner surface of the channel to inhibit reverse movement of the plunger. A cleaning material contains a cleaning agent and is positioned around the rod member and compressed between the bottom of the inner cavity and the shoulder of the plunger to release the cleaning agent around the shoulder to contact the male protrusion.

Abstract: A surgical tissue therapy device includes a sealant layer and a collection chamber. The sealant layer functions so as to create a sealed enclosure or space between it and the surface of a patient by forming, preferably, an airtight seal around a surgical area of skin trauma. The closed incision tissue therapy device also comprises a collection chamber, which may comprise an elongate tubular chamber with a plurality of longitudinally spaced openings. The collection chamber may be configured to be in fluid communication with the sealant layer and the area of skin trauma and functions as to distribute the negative pressure applied to a surgically closed area of skin trauma. Preferably, the pressure under the sealant layer is reduced by expanding the volume of the enclosure space and thereby decreasing the density of air molecules under the sealant layer.

Abstract: An injection device has a dispensing chamber housing, a plunger, and a temperature control device. The dispensing chamber housing has a first part and a second part. The first part is thermally coupled to a needle. The second part is thermally coupled to the first part. The second part has an inner surface and an outer surface. The inner surface partially defines a dispensing chamber for holding a quantity of a substance. The plunger is engaged with an inner surface of the dispensing chamber housing, is capable of sliding in the dispensing chamber housing, and is fluidly sealed to the inner surface of the dispensing chamber housing. The temperature control device at least partially surrounds the dispensing chamber housing and is capable of altering a temperature of the substance in the dispensing chamber. The second part has a greater thermal coefficient than the first part.

Abstract: The present invention relates to a medicament delivery device comprising a drive means configured to act on a medicament container for expelling a medicament; a holding means configured to hold said drive means in a pre-tensioned state; an activation means configured to interact with said holding means for releasing said drive means from the pre-tensioned state; wherein the device further comprises feedback means configured to interact both with said holding means and with said drive means for generating an audible and/or tactile and/or visual signal indicating that the medicament has been completely expelled.

Abstract: In some embodiments, a method includes producing, from an adapter, a first wireless signal characterized by a first communication mode with a computing device when a portion of at least one of a medicament delivery device or a simulated medicament delivery is disposed within the adapter. An indication is received when the portion of the medicament delivery device or the simulated medicament delivery device is removed from the adapter. A second wireless signal characterized by a second communication mode with the computing device is produced in response to the indication. The second communication mode is different from the first communication mode. The second communication mode can be, for example, a hold mode, a sniff mode or a park mode.

Abstract: A method and apparatus for measuring a volume of a wound are described, the method comprising the steps of: applying a dressing over a wound, the volume of which is to be measured, the dressing including at least a sealing drape over the wound so as to create a sealed wound cavity; creating a vacuum in said wound cavity by vacuum pump means so as to produce a predetermined vacuum in the wound cavity; measuring a volume of air extracted from said wound cavity in producing said predetermined vacuum; and, calculating a volume of said wound.

Abstract: The invention relates to an auto-injector for administering a dose of a liquid medicament (M), comprising: an elongate outer casing arranged to contain a syringe with a hollow needle and a stopper for sealing the syringe and displacing the medicament (M), the outer casing having a distal end (D) and a proximal end (P) with an orifice intended to be applied against an injection site, wherein the syringe is slidably arranged with respect to the outer casing, spring means capable of, upon activation: pushing the needle past the proximal end (P), operating the syringe to supply the dose of medicament (M), and retracting the syringe with the needle activating means arranged to lock the spring means in a pressurized state prior to manual operation and capable of, upon manual operation, releasing the spring means for injection, wherein the spring means is a torsion spring grounded at one end in the outer casing and at the other end in a first gear member rotatable about a longitudinal axis, wherein the first g

Abstract: This pharmaceutical injection system is provided with a pharmaceutical injection device, a charging device, a detector, and an alarm section. The pharmaceutical injection device has a main body case and a pharmaceutical syringe mounting portion provided within the main body case and to which a pharmaceutical syringe is removably mounted. The pharmaceutical injection device is placed in the charging device, and the charging device has a charger for charging the pharmaceutical injection device. The detector is provided to the pharmaceutical injection device and/or the charging device and detects whether or not the pharmaceutical syringe has been mounted to the pharmaceutical syringe mounting portion. The alarm section is connected to the detector and emits an alarm when it is detected that the pharmaceutical syringe has been mounted onto the pharmaceutical syringe mounting portion.

Abstract: The invention relates to the use of plasma treated silicone oil as a coating in a medical injection device (1) comprising a barrel (2) and a stopper (3) in gliding engagement within the barrel, for limiting the number of particles present on the surface of the coating and for limiting the number of particles released in a pharmaceutical composition contained in the injection device.

Abstract: The present invention provides a sterile solution comprising octreotide acetate in a pharmaceutically acceptable vehicle, wherein solution is present as a reservoir in a multiple dose pen injection device, the device being adapted to subcutaneously inject a portion of the said reservoir in multiple daily doses and further being adapted to provide multiple portions of the said solution, while the reservoir remains sterile.

Abstract: A syringe adapter mountable to a syringe, particularly a retractable syringe having a retractable needle, comprises a sealing member and an adapter body that comprises two or more body members that co-operate to retain the sealing member in the adapter. One or the other body members is removably mountable to a barrel of the syringe and one or the other body members comprises a mounting member. A filter member may be removably mounted to, or formed integrally with, the mounting member to filters fluid when filling the syringe to thereby remove particular material, impurities or the like. Alternatively, a filter material may be provided in the syringe adapter. In addition, or alternatively, a filling needle is provided which is removably mountable to the syringe adapter and may prevent bending or burring of the retractable needle.

Abstract: There are provided a needle-equipped syringe barrel and a needle-equipped syringe in which a needle is suitably fixed to a syringe nozzle, and a mold and a method for molding thereof. A metal needle 12 is integrally equipped to a synthetic resin syringe nozzle 113 by integral molding, an area where the needle 12 comes into contact with the nozzle 113 being in a range of 11 to 50 mm2. A needle-equipped syringe barrel 1 in which a metal needle 12 is integrally equipped to a synthetic resin syringe nozzle 113 by integral molding, height of a needle end 122 extruded toward an inner hollow portion thereof opposite to a needle head 121 being in a range of 0.4 to 11 mm.

Abstract: Provided is a PTFE skived film capable of exhibiting, with a single layer, sliding properties, barrier properties with regard to a liquid contact surface, and excellent tear resistance during injection molding. This skived film is characterized by being obtained by cutting a polytetrafluoroethylene block or a modified polytetrafluoroethylene block subjected to a thermal fusion treatment under reduced pressure or subjected to a pressurized thermal fusion treatment after being subjected to fusion under reduced pressure.

Abstract: Syringe assemblies comprising a disinfecting reservoir collar to ensure adherence to aseptic techniques for use in flush procedures for vascular access devices (VAD's) are described. The syringe assemblies include a plunger rod, a syringe barrel, and reservoir collar that permits disinfection of a hub of a VAD connector upon connection to the reservoir collar. Also described are methods of disinfecting vascular access devices.

Abstract: A syringe includes a barrel and a rotatable element on the barrel; for example at a proximal location along the length of the barrel. The rotatable element rotates at least partially around the barrel. When a handle is associated with the rotatable element, the barrel may rotate as the handle is held substantially stationary or the handle may be rotated while the barrel and any peripheral device secured thereto remain substantially stationary. When handles are associated with a rotatable element that may be removed from a barrel, a barrel that is disassembled from the rotatable element may be replaced with another barrel of the same or a different configuration. The barrel and plunger may be configured to cause the barrel to rotate as the plunger moves along the length of the barrel. Methods of using a syringe with a rotatable element on a barrel thereof are also disclosed.